bims-ovdlit 2026-08-16 papers

Histopathology. 2026 Aug 12.

Additional sectioning and AI-assisted diagnosis reveal underdiagnosis of serous (pre)malignancies in fallopian tube specimen from BRCA1/2 carriers.

Anouk B Bouwmeester, Tamar A Gootzen, Marielle Nobbenhuis, Vilius Rudaitis, Caroline B van den Berg, Heleen J van Beekhuizen, Luthy Sm Alcalá, Dineke Pm Smedts, Nicole Cm Visser, Viola Verhoef, Trudy Gn Jonges, Ronald P Zweemer, Alicia Leon-Catillo, Carlijn Lems, Joanne A de Hullu, Jeroen Awm van der Laak, Miranda P Steenbeek, Michiel Simons.

AIM: Germline BRCA1/2 pathogenic variant carriers are at increased risk for high-grade serous carcinoma (HGSC) and are therefore advised to have a risk-reducing salpingo-oophorectomy (RRSO) around the age of 40. A risk of 0.9% to develop peritoneal HGSC (pHGSC) remains, which increases up to 27.5% when serous tubal intraepithelial carcinoma (STIC) is detected at RRSO. The relationship between the detection of STIC and the occurrence of pHGSC is still poorly understood. Here, we investigated the role of tissue sampling by examining deeper sections of the tubal tissue of RRSO specimens.
METHODS: Four groups of patients were included: (1) STIC without pHGSC (n = 5); (2) STIC with pHGSC (n = 4); (3) no STIC and no pHGSC (n = 5); and (4) no STIC and pHGSC (n = 5). Follow-up time was 10 years or until the development of pHGSC. Deeper sections were cut at 150 μm intervals. A deep learning model was used to support STIC detection.
RESULTS: A focus of isolated STIC or HGSC was found in the deeper sections of all patients who developed pHGSC, while these patients did not have STIC or HGSC at the initial diagnosis. No patients with STIC and pHGSC showed HGSC in the deeper sections. We observed that five STICs presented as serous tubal intraepithelial lesions (STILs) in adjacent slides based on low Ki-67 expression.
CONCLUSIONS: Our findings underscore the hypothesis that pHGSC originates in the fallopian tube and confirm that invasiveness is not necessary for disease progression of STIC towards pHGSC. Furthermore, deeper sections might be of additional value when STIL is diagnosed.

Keywords: high‐grade serous carcinoma; ovarian cancer; salpingo‐oophorectomy; sampling error; serous tubal intraepithelial carcinoma

DOI: https://doi.org/10.1111/his.70249

Front Oncol. 2026 ;16 1935377

Editorial: Equity in cancer prevention and early detection.

Hussain Gadelkarim Ahmed, Abdelbaset Mohamed Elasbali.

Keywords: cancer diagnosis; cancer incidence; cancer prevention; cancer screening; early detection

DOI: https://doi.org/10.3389/fonc.2026.1935377

Nat Rev Genet. 2026 Aug 11.

Genetics and genomics of hybridization.

Molly Schumer, Loren H Rieseberg.

Once considered rare in some species groups, we now appreciate that hybridization between distinct lineages is a feature of essentially all branches of the eukaryotic tree of life. Determining the drivers of hybridization across species and locally along genomes is not just a question of history; it is fundamental to understanding genomic variation, adaptation and even disease risk across diverse species. Here, we start by reviewing methodological advances that may improve our understanding of the frequency of hybridization and its evolutionary effects. Next, we compile results from traditional and genomic sources of evidence to estimate the incidence of hybridization in nature and discuss the causes and consequences of this key evolutionary process. Finally, we highlight open questions, including whether hybridization promotes diversification, and how such questions could be addressed in the future.

DOI: https://doi.org/10.1038/s41576-026-00995-7