bims-ovdlit Biomed News
on Ovarian cancer: early diagnosis, liquid biopsy and therapy
Issue of 2023‒08‒27
three papers selected by
Lara Paracchini, Humanitas Research

  1. Ann Oncol. 2023 Aug 10. pii: S0923-7534(23)00797-4. [Epub ahead of print]
    ESMO Guidelines Committee
    Keywords:  diagnosis; epithelial ovarian cancer; follow-up; guideline; surgery; treatment
  2. Cold Spring Harb Perspect Med. 2023 Aug 21. pii: a041337. [Epub ahead of print]
      The risk of death from ovarian cancer is highly associated with the clinical stage at diagnosis. Efforts to implement screening for ovarian cancer have been largely unsuccessful, due to the low prevalence of the disease in the general population and the heterogeneity of the various cancer types that fall under the ovarian cancer designation. A practical test for early detection will require both high sensitivity and high specificity to balance reducing the number of cancer deaths with minimizing surgical interventions for false positive screens. The technology must be cost-effective to deliver at scale, widely accessible, and relatively noninvasive. Most importantly, a successful early detection test must be effective not only at diagnosing ovarian cancer but also in reducing ovarian cancer deaths. Stepwise or multimodal approaches among the various areas under investigation will likely be required to make early detection a reality.
  3. Hum Cell. 2023 Aug 24.
    Keywords:  CTLA-4; Debulking surgery; High-grade serous; Ovarian cancer; Residual tumors