bims-nocaut Biomed News
on Non-canonical autophagy
Issue of 2026–04–26
two papers selected by
Quentin Frenger, University of Strasbourg
  1. A pressure relief valve for lysosomes.
  2. LC3-associated phagocytosis is a new strategy to inhibit picornavirus infection through increasing interferon levels and lysosomal degradation.
  1. J Cell Biol. 2026 May 04. pii: e202604009. [Epub ahead of print]225(5):
    A pressure relief valve for lysosomes.
    Layla M Nassar, Shawn M Ferguson.
      Several mechanisms repair damaged lysosomal membranes, but how can lysosomes prevent membrane failure in the first place? Kim et al. (https://doi.org/10.1083/jcb.202509180) uncover a rapid response whereby TMEM63A-dependent ion efflux relieves membrane tension, buying time for slower repair mechanisms to engage.
    DOI:  https://doi.org/10.1083/jcb.202604009
  2. Cell Mol Life Sci. 2026 Apr 22.
    LC3-associated phagocytosis is a new strategy to inhibit picornavirus infection through increasing interferon levels and lysosomal degradation.
    Xiuping Wu, Yi Ru, Wei Zhang, Rongzeng Hao, Xiaodong Qin, Haimi Dang, Dongmei Zhao, Bingzhou Lu, Yajun Li, Shengzhen Sun, Yang Yang, Haixue Zheng.
      
    Keywords:  CRISPR/Cas9; Canonical autophagy; Innate immune response; Single-membrane phagosomes; VISA
    DOI:  https://doi.org/10.1007/s00018-026-06184-3
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