bims-mionch 2024-09-15 papers

Issue of 2024–09–15
two papers selected by
Gun Kim, Seoul National University

Int J Mol Sci. 2024 Aug 24. pii: 9206. [Epub ahead of print]25(17):

Crosstalk between Dysfunctional Mitochondria and Proinflammatory Responses during Viral Infections.

Zitao Sun, Yanjin Wang, Xin Jin, Su Li, Hua-Ji Qiu.

Mitochondria play pivotal roles in sustaining various biological functions including energy metabolism, cellular signaling transduction, and innate immune responses. Viruses exploit cellular metabolic synthesis to facilitate viral replication, potentially disrupting mitochondrial functions and subsequently eliciting a cascade of proinflammatory responses in host cells. Additionally, the disruption of mitochondrial membranes is involved in immune regulation. During viral infections, mitochondria orchestrate innate immune responses through the generation of reactive oxygen species (ROS) and the release of mitochondrial DNA, which serves as an effective defense mechanism against virus invasion. The targeting of mitochondrial damage may represent a novel approach to antiviral intervention. This review summarizes the regulatory mechanism underlying proinflammatory response induced by mitochondrial damage during viral infections, providing new insights for antiviral strategies.

Keywords: innate immunity; mitochondrial damage; mitochondrial dysfunction; proinflammatory responses

DOI: https://doi.org/10.3390/ijms25179206

Results Probl Cell Differ. 2024 ;73 3-23

Organelle Communication with the Nucleus.

Sourabh Sengupta, Daniel L Levy.

Compartmentalization of cellular components is critical to the spatiotemporal and environmental regulation of biochemical activities inside a cell, ensures the proper division of cellular labor and resources, and increases the efficiency of metabolic processes. However, compartmentalization also poses a challenge as organelles often need to communicate across these compartments to complete reaction pathways. These communication signals are often critical aspects of the cellular response to changing environmental conditions. A central signaling hub in the cell, the nucleus communicates with mitochondria, lysosomes, the endoplasmic reticulum, and the Golgi body to ensure optimal organellar and cellular performance. Here we review different mechanisms by which these organelles communicate with the nucleus, focusing on anterograde and retrograde signaling of mitochondria, localization-based signaling of lysosomes, the unfolded protein response of the endoplasmic reticulum, and evidence for nucleus-Golgi signaling. We also include a brief overview of some less well-characterized mechanisms of communication between non-nuclear organelles.

Keywords: Endoplasmic reticulum; Golgi; Inter-organellar communication; Lysosomes; Mitochondria; Nucleus

DOI: https://doi.org/10.1007/978-3-031-62036-2_1