bims-minfam Biomed News
on Inflammation and metabolism in ageing and cancer
Issue of 2023‒08‒20
five papers selected by
Ayesh Seneviratne
Western University

  1. Front Endocrinol (Lausanne). 2023 ;14 1250141
    Keywords:  aging; chronic inflammation; immune dysregulation; inflammaging; inflammatory cytokines
  2. Curr Transplant Rep. 2023 Jun;10(2): 51-59
      Purpose of review: To summarizes the literature on cellular senescence and frailty in solid-organ transplantation and highlight the emerging role of senotherapeutics as a treatment for cellular senescence.Recent findings: Solid-organ transplant patients are aging. Many factors contribute to aging acceleration in this population, including cellular senescence. Senescent cells accumulate in tissues and secrete proinflammatory and profibrotic proteins which result in tissue damage. Cellular senescence contributes to age-related diseases and frailty. Our understanding of the role cellular senescence plays in transplant-specific complications such as allograft immunogenicity and infections is expanding. Promising treatments, including senolytics, senomorphics, cell-based regenerative therapies, and behavioral interventions, may reduce cellular senescence abundance and frailty in patients with solid-organ transplants.
    Summary: Cellular senescence and frailty contribute to adverse outcomes in solid-organ transplantation. Continued pursuit of understanding the role cellular senescence plays in transplantation may lead to improved senotherapeutic approaches and better graft and patient outcomes.
    Keywords:  Aging; Biomarkers; Frailty; Senescence; Senolytics; Transplantation
  3. Biochem Pharmacol. 2023 Aug 12. pii: S0006-2952(23)00335-0. [Epub ahead of print] 115744
      Cardiovascular disease is the leading cause of death worldwide, and atherosclerosis is a major contributor to this etiology. The ligand-activated transcription factor, known as the aryl hydrocarbon receptor (AhR), plays an essential role in the interactions between genes and the environment. In a number of human diseases, including atherosclerosis, the AhR signaling pathway has recently been shown to be aberrantly expressed and activated. It's reported that AhR can regulate the immuno-inflammatory response and metabolism pathways in atherosclerosis, potentially serving as a bridge that links these processes. In this review, we highlight the involvement of AhR in atherosclerosis. From the literature, we conclude that AhR is a potential target for controlling atherosclerosis through precise interventions.
    Keywords:  Aryl hydrocarbon receptor; Atherosclerosis; Immuno-inflammation; Metabolism