bims-minfam Biomed News
on Inflammation and metabolism in ageing and cancer
Issue of 2025–04–27
six papers selected by
Ayesh Seneviratne, McMaster University
  1. Healthy diets for healthy aging.
  2. Clonal Hematopoiesis as a Driver of Solid Tumors.
  3. Telomere Length and Clonal Hematopoiesis of Indeterminate Potential: A Loop Between Two Key Players in Aortic Valve Disease?
  4. Clonal hematopoiesis-associated motoric deficits caused by monocyte-derived microglia accumulating in aging mice.
  5. Diabetes and frailty in an ageing world.
  6. Study: Diets Rich in Plant-Based Foods Tied to Healthy Aging.
  1. Nat Aging. 2025 Apr 24.
    Healthy diets for healthy aging.
    Hannah Walters.
      
    DOI:  https://doi.org/10.1038/s43587-025-00871-9
  2. N Engl J Med. 2025 Apr 24. 392(16): 1654-1656
    Clonal Hematopoiesis as a Driver of Solid Tumors.
    Lachelle D Weeks, Benjamin L Ebert.
      
    DOI:  https://doi.org/10.1056/NEJMe2504775
  3. J Cardiovasc Dev Dis. 2025 Apr 03. pii: 135. [Epub ahead of print]12(4):
    Telomere Length and Clonal Hematopoiesis of Indeterminate Potential: A Loop Between Two Key Players in Aortic Valve Disease?
    Ilenia Foffa, Augusto Esposito, Ludovica Simonini, Sergio Berti, Cecilia Vecoli.
      Aortic valve stenosis (AVS) is the most common valvular heart disease that was considered, for a long time, a passive degenerative disease due to physiological aging. More recently, it has been recognized as an active, modifiable disease in which many cellular processes are involved. Nevertheless, since aging remains the major risk factor for AVS, a field of research has focused on the role of early (biological) aging and its dependent pathways in the initiation and progression of AVS. Telomeres are regions at the ends of chromosomes that are critical for maintaining genome stability in eukaryotic cells. Telomeres are the hallmarks and molecular drivers of aging and age-related degenerative pathologies. Clonal hematopoiesis of indeterminate potential (CHIP), a condition caused by somatic mutations of leukemia-associated genes in individuals without hematologic abnormalities or clonal disorders, has been reported to be associated with aging. CHIP represents a new and independent risk factor in cardiovascular diseases, including AVS. Interestingly, evidence suggests a causal link between telomere biology and CHIP in several pathological disorders. In this review, we discussed the current knowledge of telomere biology and CHIP as possible mechanisms of aortic valve degeneration. We speculated on how a better understanding of the complex relationship between telomere and CHIP might provide great potential for an early diagnosis and for developing novel medical therapies to reduce the constant increasing health burden of AVS.
    Keywords:  CHIP; aging; aortic valve stenosis; clonal hematopoiesis of indeterminate potential; telomere length
    DOI:  https://doi.org/10.3390/jcdd12040135
  4. Cell Rep. 2025 Apr 24. pii: S2211-1247(25)00380-8. [Epub ahead of print]44(5): 115609
    Clonal hematopoiesis-associated motoric deficits caused by monocyte-derived microglia accumulating in aging mice.
    Netherlands Brain Bank
      Microglia are parenchymal brain macrophages that are established during embryogenesis and form a self-containing cellular compartment that resists seeding with cells derived from adult definitive hematopoiesis. We report that monocyte-derived macrophages (MoMΦs) accumulate in the brain of aging mice with distinct topologies, including the nigrostriatum and medulla but not the frontal cortex. Parenchymal MoMΦs adopt bona fide microglia morphology and expression profiles. Due to their hematopoietic stem cell (HSC) derivation, monocyte-derived microglia (MoMg) are unlike yolk-sac-derived cells, targets of clonal hematopoiesis (CH). Indeed, using a chimeric transfer model, we show that the hematopoietic expression of DNMT3AR882H, a prominent human CH variant, renders MoMg pathogenic and promotes motor deficits resembling atypical Parkinsonian disorders. Collectively, we establish that MoMg progressively seed the brain of healthy aging mice, accumulate in selected areas, and, when carrying a somatic mutation associated with CH, can cause brain pathology.
    Keywords:  ARCH; CH; CHIP; CP: Immunology; CP: Neuroscience; DNMT3A R882H; HSC; brain macrophages; clonal hematopoiesis; microglia; monocytes
    DOI:  https://doi.org/10.1016/j.celrep.2025.115609
  5. Lancet Diabetes Endocrinol. 2025 May;pii: S2213-8587(25)00094-4. [Epub ahead of print]13(5): 355
    Diabetes and frailty in an ageing world.
    The Lancet Diabetes Endocrinology.
      
    DOI:  https://doi.org/10.1016/S2213-8587(25)00094-4
  6. JAMA. 2025 Apr 25.
    Study: Diets Rich in Plant-Based Foods Tied to Healthy Aging.
    Samantha Anderer.
      
    DOI:  https://doi.org/10.1001/jama.2025.4676
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