bims-minfam Biomed News
on Inflammation and metabolism in ageing and cancer
Issue of 2024–11–24
seven papers selected by
Ayesh Seneviratne, McMaster University
  1. Boosting NAD+ in patients with COPD reduces airway inflammation.
  2. Sarcopenia and the biological determinants of aging: A narrative review from a geroscience perspective.
  3. Dysregulation of endogenous retroviruses triggers aging and senescence.
  4. Mapping aged stem cell states associated with decline in skeletal muscle regeneration.
  5. Linking ferroptosis to thymic involution.
  6. Human Plasma Proteomic Profile of Clonal Hematopoiesis.
  7. Clonal Hematopoiesis of Indeterminate Potential and Cardiovascular Health.
  1. Nat Aging. 2024 Nov 20.
    Boosting NAD+ in patients with COPD reduces airway inflammation.
      
    DOI:  https://doi.org/10.1038/s43587-024-00765-2
  2. Ageing Res Rev. 2024 Nov 19. pii: S1568-1637(24)00405-7. [Epub ahead of print] 102587
    Sarcopenia and the biological determinants of aging: A narrative review from a geroscience perspective.
    Mariá Nunes-Pinto, Renato Gorga Bandeira de Mello, Milena Nunes Pinto, Cédric Moro, Bruno Vellas, Laurent O Martinez, Yves Rolland, Philipe de Souto Barreto.
       BACKGROUND: The physiopathology of sarcopenia shares common biological cascades with the aging process, as does any other age-related condition. However, our understanding of the interconnected pathways between diagnosed sarcopenia and aging remains limited, lacking sufficient scientific evidence.
    METHODS: This narrative review aims to gather and describe the current evidence on the relationship between biological aging determinants, commonly referred to as the hallmarks of aging, and diagnosed sarcopenia in humans.
    RESULTS: Among the twelve hallmarks of aging studied, there appears to be a substantial association between sarcopenia and mitochondrial dysfunction, epigenetic alterations, deregulated nutrient sensing, and altered intercellular communication. Although limited, preliminary evidence suggests a promising association between sarcopenia and genomic instability or stem cell exhaustion.
    DISCUSSION: Overall, an imbalance in energy regulation, characterized by impaired mitochondrial energy production and alterations in circulatory markers, is commonly associated with sarcopenia and may reflect the interplay between aging physiology and sarcopenia biology.
    Keywords:  Sarcopenia; age-related diseases; geroscience; hallmarks of aging
    DOI:  https://doi.org/10.1016/j.arr.2024.102587
  3. Nat Aging. 2024 Nov 20.
    Dysregulation of endogenous retroviruses triggers aging and senescence.
    Jill A Kreiling.
      
    DOI:  https://doi.org/10.1038/s43587-024-00759-0
  4. Nat Aging. 2024 Nov 22.
    Mapping aged stem cell states associated with decline in skeletal muscle regeneration.
      
    DOI:  https://doi.org/10.1038/s43587-024-00768-z
  5. Nat Aging. 2024 Nov 22.
    Linking ferroptosis to thymic involution.
    Shirley Genah, Enrico Velardi.
      
    DOI:  https://doi.org/10.1038/s43587-024-00777-y
  6. bioRxiv. 2024 Oct 31. pii: 2023.07.25.550557. [Epub ahead of print]
    Human Plasma Proteomic Profile of Clonal Hematopoiesis.
    NHLBI Trans-Omics for Precision Medicine
      Plasma proteomic profiles associated with subclinical somatic mutations in blood cells may offer novel insights into downstream clinical consequences. Here, we explore such patterns in clonal hematopoiesis of indeterminate potential (CHIP), which is linked to several cancer and non-cancer outcomes, including coronary artery disease (CAD). Among 61,833 ancestrally diverse participants (3,881 with CHIP) from NHLBI TOPMed and UK Biobank with blood-based DNA sequencing and proteomic measurements (1,148 proteins by SomaScan in TOPMed and 2,917 proteins by Olink in UK Biobank), we identified 32 and 345 unique proteins from TOPMed and UK Biobank, respectively, associated with the most prevalent driver genes (DNMT3A, TET2, and ASXL1). These associations showed substantial heterogeneity by driver genes, sex, and race, and were enriched for immune response and inflammation pathways. Mendelian randomization in humans, coupled with ELISA in hematopoietic Tet2-/- vs wild-type mice validation, disentangled causal proteomic perturbations from TET2 CHIP. Lastly, we identified plasma proteins shared between CHIP and CAD.
    DOI:  https://doi.org/10.1101/2023.07.25.550557
  7. Cardiol Clin. 2025 Feb;pii: S0733-8651(24)00084-5. [Epub ahead of print]43(1): 13-23
    Clonal Hematopoiesis of Indeterminate Potential and Cardiovascular Health.
    Michael A Raddatz, Yash Pershad, Alyssa C Parker, Alexander G Bick.
      Clonal hematopoiesis of indeterminate potential (CHIP) is an age-related phenomenon in which somatic mutations lead to clonal expansion of hematopoietic stem cells without the development of hematologic abnormalities. A growing body of literature demonstrates an association between CHIP and cardiovascular disease. This pathophysiology demonstrates a novel connection between global inflammation and cardiovascular morbidity. While there is limited consensus addressing the cardiovascular care of these patients, risk factor optimization and disease surveillance are advisable. Investigation into possible therapies is ongoing and provides promise for the treatment of inflammation contributing to cardiovascular disease in patients with and without CHIP.
    Keywords:  Atherosclerosis; Cardiovascular genetics; Clonal hematopoiesis; Inflammation
    DOI:  https://doi.org/10.1016/j.ccl.2024.08.004
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