bims-migras 2026-06-28 papers

Issue of 2026–06–28
two papers selected by
Cliff Dominy

Curr Cancer Drug Targets. 2026 Jun 19.

Corrigendum to: Migrasomes: A Novel Target for Cancer Treatment.

In the article titled "Migrasomes: A Novel Target for Cancer Treatment", published in Current Cancer Drug Targets, 2026, 26(2), 153-161 [1], the DOI number provided for Reference [45] was incorrect. The original article can be found online at: https://www.benthamscience.com/issue/14684. Details of the correction are as follows: Original: [45] Nam, G.; Choi, Y.; Kim, G.; Kim, S.; Kim, S.; Kim, I. Emerging prospects of exosomes for cancer treatment: From conventional therapy to immunotherapy. Adv Mater., 2020, 32(51), e2002440. http://dx.doi.org/0.1002/adma.202002440 Corrected: [45] Nam, G.; Choi, Y.; Kim, G.; Kim, S.; Kim, S.; Kim, I. Emerging prospects of exosomes for cancer treatment: From conventional therapy to immunotherapy. Adv Mater., 2020, 32(51), e2002440. http://dx.doi.org/10.1002/adma.202002440.

DOI: https://doi.org/10.2174/1568009626999260619155514

Transl Res. 2026 Jun 23. pii: S1931-5244(26)00133-7. [Epub ahead of print]

Pien-Tze-Huang inhibits colorectal cancer liver metastasis in mice by modulating immunosuppressive and fibrotic microenvironments.

Shicong Wang, Yi He, Bin Liu, Youhong Zeng, Gaoliang Ouyang, Tiantian Wu.

Pien-Tze-Huang (PZH) is a well-known traditional Chinese medicine with anti-inflammation and anti-tumor effects. However, its role in tumor metastasis remains largely unknown. In this study, we found that PZH significantly inhibits the liver metastasis of colorectal cancer (CRC) cells in mice. PZH reduces the polarization of macrophages toward the pro-tumor M2 subtype and shifts the immune microenvironment to a tumor-suppressive microenvironment. Moreover, PZH suppresses hepatic stellate cell (HSC) activation and alleviates the fibrotic microenvironment in liver metastatic tissues of mice. We further demonstrated that PZH inhibits the recruitment and M2 polarization of macrophages and the activation of HSCs by decreasing the formation of migrasomes in CRC cells. Our findings suggest that PZH can inhibit liver metastasis of CRC cells in mice by modulating the immune and stromal components of the tumor microenvironment, offering a promising therapeutic strategy for CRC patients with liver metastasis.

Keywords: Colorectal cancer; Liver metastasis; Migrasomes; Pien-Tze-Huang; Tumor microenvironment

DOI: https://doi.org/10.1016/j.trsl.2026.06.014