bims-migras 2026-10-11 papers

Issue of 2026–10–11
three papers selected by
Cliff Dominy

Tissue Barriers. 2026 Oct 07. 2738431

Emerging roles of migrasomes in blood-tissue barrier integrity and intercellular signaling.

Amal Ahmed El-Sheikh, Rashid A Aldahhan.

Migrasomes are a newly recognized class of migration-dependent organelles that arise along retraction fibers of migrating cells and are released into the extracellular milieu. Structurally and biogenetically distinct from extracellular vesicles, migrasomes function as signaling hubs that mediate localized transfer of bioactive cargo and coordinate intercellular communication. Accumulating evidence indicates that migrasomes participate in diverse biological processes, including developmental patterning, immune regulation, and tumor progression. Blood-tissue barriers (including the blood-brain, glomerular, thymic, retinal, and placental barriers) are specialized interfaces that regulate molecular and cellular exchange between the circulation and tissues. These barriers rely on tightly coordinated interactions among barrier-forming endothelial cells, junctional complexes, basement membranes, and supporting stromal components to preserve tissue homeostasis. Despite emerging studies on migrasome biology, a comprehensive mechanistic understanding of migrasome-barrier interactions across the full spectrum of blood-tissue barrier systems remains lacking. This review addresses that gap by proposing an integrative conceptual framework for migrasome signaling within barrier microenvironments, examining how migrasome-mediated signaling influences cellular crosstalk and functional regulation within these interfaces in both health and disease. We also discuss technological advances, current limitations, and key knowledge gaps, highlighting the need for barrier-focused mechanistic studies to determine whether migrasomes act as active regulators of barrier integrity and signaling or represent secondary byproducts of cellular migration within barrier microenvironments.

Keywords: Blood–tissue barriers; cell migration; extracellular vesicles; intercellular signaling; migrasomes

DOI: https://doi.org/10.1080/21688370.2026.2738431

J Extracell Vesicles. 2026 Oct;15(10): e70377

C1qc Mediates Blood-Brain Barrier Disruption in a Mouse Model of Intracerebral Haemorrhage Through Microglia-Derived Migrasomes.

Mengyuan Li, Zhihua Li, Dengpan Song, Fang Wang, Mengzhao Feng, Chi-Tai Yeh, Tingting Zhai, Menghan Deng, Yanyan Sun, Junyang Wang, Xuemei Chen, Yating Wang, Qiong Yang, Moxin Wu, Xiaoping Yin, Junmin Wang, Jian Wang, Fuyou Guo.

Extracellular vesicles (EVs) are essential for intercellular communication and significantly influence neuroimmune responses after intracerebral haemorrhage (ICH). This study elucidates the immune mechanisms underlying secondary brain injury following ICH by identifying microglia-derived migrasomes. By integrating immune cell clustering analysis from single-cell RNA sequencing (scRNA-seq) with Mendelian randomization, we identified five key genes associated with ICH. Further experiments revealed that C1qc accumulates around hematomas, worsening blood‒brain barrier (BBB) disruption through migrasome-mediated pathways. Our results showed that microglial migrasomes transport C1qc to induce pyroptosis in vascular endothelial cells, thereby compromising BBB integrity. Genetic ablation of C1qc substantially attenuated this BBB damaging effect, C1qc-deficient migrasomes exhibited protective properties. Our findings, for the first time, reveal the mechanistic role of C1qc and migrasomes in ICH pathogenesis and establish microglia-derived migrasomes as promising therapeutic targets, providing novel avenues to improve neurologic outcomes after ICH.

Keywords: C1qc; blood‒brain barrier; intracerebral haemorrhage; microglia; migrasomes

DOI: https://doi.org/10.1002/jev2.70377

Nat Rev Mol Cell Biol. 2026 Oct 05.

Towards a systematic understanding of the diverse subtypes, biogenesis and functions of large extracellular vesicles.

Yuwei Huang, Renxiang Xie, Junjie Ma, Li Yu.

Large extracellular vesicles (lEVs) are heterogeneous structures with sizes that exceed 200 nm. Unlike small extracellular vesicles, which originate from either the endosomal system or the plasma membrane, most lEVs stem directly from the plasma membrane, although the various lEV subtypes have distinct biogenesis pathways. Emerging findings have helped to update lEV classification and have provided insights into lEV biogenesis, cargo, physiological functions and relevance in disease. Classical lEVs include apoptotic bodies, microvesicles and large oncosomes, whereas detached migrasomes, exophers, mitophers, blebbisomes, large ageing neutrophil-derived vesicles were only identified later. The study of these diverse lEV subtypes has been challenging, but emerging technologies, including tools that enable multidimensional characterization, loss-of-function studies and mechanistic analyses, are likely to advance the field further, especially if they are appropriately integrated to ensure rigour and reproducibility.

DOI: https://doi.org/10.1038/s41580-026-01021-8