bims-migras 2026-05-31 papers

Issue of 2026–05–31
two papers selected by
Cliff Dominy

Cell Commun Signal. 2026 May 25.

Neural mesenchymal-like fibroblast-derived migrasomes promote Schwann cell proliferation and migration via tenascin-C transfer during peripheral nerve regeneration.

Yongbin Ma, Qian Wang, Hang Yu, Xingwen Chen, Yue Liu, Shang Wang, Yunxia Fan, Dan Zhou, Juan Wang, Yu Feng, Liyang Dong, Tao Li.

Peripheral nerve regeneration involves intricate intercellular communication between fibroblasts and Schwann cells (SCs). Migrasomes are recently identified extracellular vesicles generated in migrating cells that facilitate intercellular communication. In this study, we report that following peripheral nerve injury, neural mesenchymal-like fibroblasts (NMLFs) undergo extensive proliferation and expansion, with the concurrent production of migrasomes. These NMLF-derived migrasomes not only promote SC proliferation and migration but also act crucially as directional cues to guide SC migration. We demonstrate that mechanistically, NMLF migrasomes facilitate SC proliferation and migration through the transfer of tenascin-C (TNC). Collectively, our findings reveal a novel migrasome-mediated communication mechanism between NMLFs and Schwann cells, highlighting migrasomes as a promising therapeutic target for enhancing peripheral nerve regeneration.

Keywords: Migrasome; Neural mesenchymal-like fibroblasts; Peripheral nerve regeneration; Schwann cells; Tenascin-C

DOI: https://doi.org/10.1186/s12964-026-02965-2

J Nanobiotechnology. 2026 May 29.

A migrasome-based osteoinductive strategy: reprogramming the bone microenvironment for accelerated coupling of angiogenesis and osteogenesis.

Leyi Liu, Jie Wu, Shilin Jia, Yi He, Yunyang Lu, Runze Li, Shiyu Lv, Wei Zhao, Dongsheng Yu.

The spatiotemporal coupling of osteogenesis and angiogenesis mediated by type H vessels represents a fundamental mechanism in bone formation. Although macrophages, the key immunomodulatory cells in the bone microenvironment, are known to participate in the regulation of type H vessels, the underlying mechanisms still remain insufficiently understood. The role of migrasomes, a newly discovered class of substrate-anchored extracellular vesicles, in macrophage-type H vessel crosstalk during bone regeneration were investigated in this study. M2 macrophage-derived migrasomes (RAW-MS) were produced by stimulating RAW 264.7 cells with fibronectin (FN). In vitro experiments indicated that RAW-MS were internalized by recipient cells, thereby promoting anti-inflammatory macrophage polarization, enhancing angiogenic activity, and facilitating osteogenic differentiation. Proteomic analysis revealed that RAW-MS were enriched with numerous angiogenesis-associated proteins. Transcriptome sequencing and subsequently in vitro experiments demonstrated that RAW-MS activated the endothelial tip cells phenotype and sprouting angiogenesis via TGFβ1/Smad2 signaling pathway. When incorporated into GelMA hydrogels, RAW-MS significantly improved vascularized bone regeneration in a critical-sized rat cranial defect model. Both in vitro and in vivo investigations consistently showed that RAW-MS enhanced the coupling of angiogenesis and osteogenesis accompanied by an increased density of type H vessel formation through upregulation of the TGFβ1/Smad2 signaling. In conclusion, this study highlighted the potential of migrasomes as innovative signaling vehicles for manipulating the regenerative microenvironment in tissue engineering.

Keywords: Macrophage; Migrasomes; TGFβ signaling; Tip cells; Type H vessel

DOI: https://doi.org/10.1186/s12951-026-04619-4