bims-migras 2025-10-12 papers

Issue of 2025–10–12
two papers selected by
Cliff Dominy

Biologics. 2025 ;19 561-579

Migrasomes: A New Role in Disease Diagnosis and Treatment.

Xiaolin Zhang, Shang Wang, Yuyun Jiang, Wei Zhu, Yanwei Yang, Liyue Huo, Yubei Zhang, Yuepeng Zhou, Zhe Yang, Xuefeng Wang.

Migrasomes, vesicle-like organelles observed during cell migration, have emerged as a significant focus in cell biology. These organelles play a pivotal role in intercellular communication, signal transduction, and tissue development through the release of signalling molecules. Evidence indicates that the pathogenesis and progression of various diseases are closely associated with aberrant cell migration, impaired intercellular communication, and disrupted signalling pathways. Notably, migrasomes can facilitate the invasion and metastasis of tumor cells: they carry metastasis-promoting signals and help form an immunosuppressive microenvironment. Additionally, migrasomes mediate viral spread. Migrasomes derived from macrophages can accelerate the progression of cardiovascular and cerebrovascular diseases by promoting neuroinflammation and neuronal damage. Meanwhile, migrasomes derived from podocytes serve as biomarkers for early kidney injury. Thus, elucidating the role of migrasomes in pathological processes and defining their specific functions holds great promise for developing novel therapeutic strategies for diseases. This review synthesizes current advances in migrasome biology, highlighting their potential as diagnostic biomarkers and therapeutic targets for conditions such as cancer, viral infections, and renal disorders.

Keywords: cell migration; diagnosis and therapy; diseases; migrasomes

DOI: https://doi.org/10.2147/BTT.S547672

PLoS Pathog. 2025 Oct;21(10): e1013557

Vimig: The virus-induced migrasome as a novel mechanism for viral transmission and communication.

Mingyan Feng, Leiliang Zhang.

Vimig, defined as "virus-induced migrasome," represents a novel class of extracellular vesicles that originate from virus-infected cells. The mechanisms underlying vimig formation involve actin remodeling and upregulation of phosphatidylinositol (4,5)-bisphosphate (PI(4,5)P2). Vimig not only encapsulates viral particles but also aids in the transport of damaged organelles, including mitochondria, thereby contributing to cellular homeostasis and potentially enhancing viral spread and infection. Characterized by their unique contents, which includes viral particles, lipids, proteins, and cellular debris, vimig serves as a transmission route for viruses, possibly allowing them to evade host immune responses. This pearl summarizes the biogenesis, functional significance, and implications of vimig in viral pathogenesis, emphasizing its potential as a target for therapeutic interventions aimed at mitigating viral infections. Understanding the role of vimig may pave the way for novel strategies in clinical drug development and deepen our insights into virus-host interactions.

DOI: https://doi.org/10.1371/journal.ppat.1013557