bims-migras Biomed News
on Migrasomes
Issue of 2025–08–24
two papers selected by
Cliff Dominy
  1. Biogenesis, functional roles, and pathological implications of migrasomes.
  2. Migrasome-Related Prognostic Genes in Gastric Cancer: A Transcriptomic and Immunotherapeutic Analysis.
  1. Cell Death Dis. 2025 Aug 19. 16(1): 629
    Biogenesis, functional roles, and pathological implications of migrasomes.
    Xuexue Liu, Dun Liu, Heng Zhao, Kangxue Wu, Shaoping Yin, Xian Yang, Chuanqin Chen, Xiaolong Ma, Yonghuan Mao, Haixia Zhang, Lihua Shao, Siliang Wang, Xiao Du.
      Migrasomes are a newly discovered type of organelle, typically located at the tips or intersections of retraction fibers, containing vesicles of various sizes and numbers. During cell migration, migrasomes expand in size, are accompanied by the rupture of retraction fibers, and eventually enter the intercellular space or are absorbed by neighboring cells. Increasing research has shown that migrasomes play crucial roles in cellular growth and development, including maintaining intracellular homeostasis and facilitating intercellular communication. This review focuses on the biogenesis, functions, and pathological roles of migrasomes, while also exploring their future research prospects. As a novel mechanism of intercellular communication, migrasomes hold immense potential for therapeutic applications. A deeper understanding of how to leverage their physiological functions for disease diagnosis and treatment will be a critical focus of future investigations.
    DOI:  https://doi.org/10.1038/s41419-025-07943-z
  2. Onco Targets Ther. 2025 ;18 873-897
    Migrasome-Related Prognostic Genes in Gastric Cancer: A Transcriptomic and Immunotherapeutic Analysis.
    Wei Qiu, Ke Zhang, Wei Hu, DongSheng Liu.
       Introduction: Gastric cancer (GC) remains one of the leading causes of cancer-related deaths worldwide, characterized by complex pathogenesis and poor prognosis. Migrasomes, as newly discovered organelles, play crucial roles in tumor microenvironment modulation and immune regulation. However, their specific mechanisms in GC remain largely unknown.
    Methods: This study integrated GC transcriptomic data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases with 35 migrasome-related genes (MRGs) to identify differentially expressed genes through bioinformatics analysis. A prognostic model was constructed using least absolute shrinkage and selection operator (LASSO) and Cox regression, and subsequent analyses were conducted through gene set enrichment analysis (GSEA), immune infiltration assessment, and drug sensitivity evaluation. Key gene expressions were further verified in clinical samples via reverse transcription quantitative polymerase chain reaction (RT-qPCR).
    Results: Eight migrasome-related prognostic genes were identified (BMP1, CPQ, PDGFD, TSPAN5, TSPAN7, TGFB2, WNT11, and LEFTY1). The developed risk-scoring model demonstrated predictive performance in both training and validation cohorts (area under the curve (AUC) > 0.6). Functional analysis revealed significant enrichment of these genes in key pathways, particularly the TGF-β signaling pathway. Immune profiling showed distinct microenvironment features in high-risk groups, along with differential sensitivity to specific chemotherapeutic agents (eg, BMS-754807). Experimental validation confirmed significant upregulation of BMP1 (p < 0.05), LEFTY1 (p < 0.05), and TGFB2 (p < 0.01), along with downregulation of TSPAN5 in GC tissues (p < 0.001).
    Conclusion: This study reveals the prognostic value of eight genes related to migrators in GC. The established risk model provides novel molecular markers and potential therapeutic targets for personalized GC treatment. These findings offer critical insights for understanding GC pathogenesis and developing innovative treatment strategies.
    Keywords:  gastric cancer; immune microenvironment; immunotherapy; migrasome; prognostic genes
    DOI:  https://doi.org/10.2147/OTT.S528050
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