bims-migras 2025-06-08 papers

Issue of 2025–06–08
four papers selected by
Cliff Dominy

Int J Biol Macromol. 2025 May 29. pii: S0141-8130(25)05347-4. [Epub ahead of print]317(Pt 2): 144795

LSD1 engaged ERα activation orchestrates the formation of migrasomes to promote gastric cancer metastasis.

Hui-Qin Kang, Ang He, Hai-Qian Nie, Bo Wang, Li-Juan Zhao, Dan-Dan Shen, Ya Gao, Hong-Min Liu, Yi-Chao Zheng.

The lysine specific demethylase 1 (LSD1) plays a vital role in promoting various malignancies, while the role of LSD1 in gastric cancer (GC) remains poorly understood. Herein, we show the critical role of LSD1 in GC migration. The overexpression of LSD1 in GC tissues, particularly in those with metastasis, indicates its potential in driving GC migration. Further mechanism study revealed that LSD1, a coregulator of ERα, is involved in the transcriptional regulation of ERα target genes, highlighting the significance of LSD1 and ERα in promoting GC cell migration. We characterized that LSD1 and ERα activation facilitated GC cell migration by promoting the generation of migrasomes mediated by the upregulated fibronectin (FN1). Upon LSD1 abrogation, a substantial decrease in the expression levels of TSPAN4 and NDST1, recognized markers of migrasomes, was observed. Our findings reveal a novel mechanism involving the interaction between LSD1, ERα, FN1 and migrasomes in facilitating GC migration.

Keywords: Gastric cancer; LSD1; Migrasome

DOI: https://doi.org/10.1016/j.ijbiomac.2025.144795

Nat Rev Mol Cell Biol. 2025 Jun 05.

Collective migration modes in development, tissue repair and cancer.

Kevin J Cheung, Sally Horne-Badovinac.

Migrating cells have key functions in shaping tissues during development, repairing tissues after development and supporting cancer invasion and metastasis. In all these contexts, cells often maintain contact with their neighbours and move as a group, in a process termed collective migration. In this Review, we describe the elegant mechanisms used by collectively migrating cells in vivo to coordinate their movements and obtain directional information. We start by highlighting the diverse physiological roles that migrating collectives have within the body and then focus on dominant paradigms for the organization of migrating collectives including the roles of leader and follower cells, local cell-cell adhesion and signalling, and external guidance cues. By comparing collective migrations occurring during development and cancer, we bring into focus shared principles for collective cell movement and distinct strategies used by cancer cells for their own dispersal. Throughout, we pay particular attention to how migrating collectives display emergent properties not exhibited by individually migrating cells and how these properties provide the robustness needed for efficient cell movement.

DOI: https://doi.org/10.1038/s41580-025-00858-9

Front Immunol. 2025 ;16 1581635

Role of extracellular vesicles in cancer: implications in immunotherapeutic resistance.

Shuai Wang, Zerui Wang, Min Liu, Xiyang Sun.

Extracellular vesicles (EVs) are lipid membrane-bound vesicles involved in cell-cell communication, particularly in the context of cancer. Immunotherapy, a rapidly evolving field in oncology, is a type of cancer treatment relying on the body's own immune system to fight mutated cancer cells. Recently, the significance of immunotherapeutic resistance has been increasingly acknowledged owing to the heightened prevalence of cancer and its commonly advanced stage upon diagnosis. However, the complexity and heterogeneity of tumor cells pose challenges to immunotherapy, and the role of EVs in immunotherapeutic resistance remains unclear. Recent studies focused on the role of EVs as heterogeneous groups of nanoparticles in intercellular communication, particularly within the tumor microenvironment (TME). EVs, which include exosomes, shed microvesicles, while apoptotic bodies carry a diverse range of molecular cargo, including proteins, nucleic acids, lipids, and other bioactive molecules. The complexity and versatility of EVs make them a fascinating area of study, with promising implications for the future of immunology and medicine. This brief review highlights the involvement of EVs in immunotherapeutic resistance (e.g., PD-L1 transfer, miRNA-mediated pathways) with a focus on their biogenesis, secretion, and functional roles in cancer, underscoring their potential as diagnostic and therapeutic tools.

Keywords: cancer progression; cell communication; extracellular vesicles; immunotherapeutic resistance; tumor microenvironment

DOI: https://doi.org/10.3389/fimmu.2025.1581635

J Cardiovasc Transl Res. 2025 Jun 02.

Extracellular Vesicles as Diagnostic Metrics for Cardiovascular Disease: Where We are and How to Achieve in Clinics.

Yujia Wang, Yingxue Yuan, Junnan Tang.

As one of the leading causes of death globally, early diagnosis and prevention of cardiovascular disease have become the focus of clinical and public health. Extracellular vesicles (EVs) are small, double-layered membrane structures actively secreted by cells and are widely present in body fluids such as blood, urine, and saliva. They carry various bioactive molecules, including proteins and nucleic acids, and are known for their remarkable stability and easy accessibility, making them promising candidates for identifying cardiovascular disease. This review summarizes the applications of EVs in the early diagnosis of cardiovascular disease, explores the potential biomarkers of proteins and RNAs (such as miRNA, lncRNA, and circRNA) contained within EVs, and discusses the prospects and challenges of EV biomarkers in clinical applications.

Keywords: Biomarker; Cardiovascular disease; Diagnosis; Extracellular vesicles

DOI: https://doi.org/10.1007/s12265-025-10629-8