bims-migras Biomed News
on Migrasomes
Issue of 2025–05–25
seven papers selected by
Cliff Dominy



  1. Cell Rep. 2025 May 22. pii: S2211-1247(25)00503-0. [Epub ahead of print]44(6): 115732
      Intercellular and inter-organ communication systems are vital for tissue homeostasis and disease development, utilizing soluble bioactive molecules for signaling. The field of extracellular vesicle (EV) biology has rapidly expanded in recent decades, highlighting EVs as effective bioactive nanovectors for cell-to-cell communication in various physiological and pathological contexts. Numerous studies indicate that adipocyte-derived EVs are crucial components of the adipose secretome, playing a key role in autocrine and paracrine interactions within adipose tissue, as well as in endocrine signaling. This review aims to present an updated perspective on EVs as mediators of communication between adipose tissue and other organs, while also examining their therapeutic potential in the light of recent advancements in EV biology research.
    Keywords:  CP: Metabolism; CP: Molecular biology; EVs; MASH; adipocyte; adipose tissue; diabetes; exosomes; extracellular vesicles; insulin resistance; liver; microvesicles; obesity
    DOI:  https://doi.org/10.1016/j.celrep.2025.115732
  2. J Nanobiotechnology. 2025 May 16. 23(1): 349
      Probiotics such as Lactobacillus and Bifidobacterium spp. have been shown to be critical for maintaining host homeostasis. In recent years, key compounds of postbiotics derived from probiotic metabolism and cellular secretion have been identified for their role in maintaining organ immunity and regulating intestinal inflammation. In particular, probiotic-derived extracellular vesicles (PEVs) can act as postbiotics, maintaining almost the same functional activity as probiotics. They also have strong biocompatibility and loading capacity to carry exogenous or parental active molecules to reach distal organs to play their roles. This provides a new direction for understanding the intrinsic microbiota-host communication mechanism. However, most current studies on PEVs are limited to their functional effects/benefits, and their specific physicochemical properties, composition, intrinsic mechanisms for maintaining host homeostasis, and possible threats remain to be explored. Here, we review and summarize the unique physicochemical properties of PEVs and their bioactivities and mechanisms in mediating microbiota-host communication, and elucidate the limitations of the current research on PEVs and their potential application as postbiotics.
    Keywords:  Extracellular vesicles (EVs); Host homeostasis; Microbiota-host communication; Postbiotics; Probiotic-derived extracellular vesicles (PEVs)
    DOI:  https://doi.org/10.1186/s12951-025-03435-6
  3. J Transl Med. 2025 May 16. 23(1): 553
      Extracellular vesicles (EVs) are membrane-bound structures released by all cell types. They play a critical role in intercellular communication by transferring their cargo, comprising proteins, lipids, metabolites, RNAs, miRNAs, and DNA fragments, to recipient cells. This transfer influences gene expression, signaling pathways, and cellular behavior. Due to their ability to alter the physiology of recipient cells, EVs hold significant therapeutic potential. Additionally, EVs are implicated in various physiological and pathological processes, including immune regulation, cancer progression, and cardiovascular diseases. EVs have been detected in many biological fluids, such as peripheral blood, saliva, urine, cerebrospinal fluid, and breast milk. The cargo of EVs dynamically reflects the physiological and pathological state of their parent cells, making them promising candidates for liquid biopsies in various clinical conditions. Specifically, different EV subtypes in cardiovascular diseases have been studied, with both endothelial and platelet-derived EVs playing significant roles in cardiovascular pathologies. This review focuses on the diagnostic and prognostic potential of endothelial and platelet-derived EVs in cardiovascular diseases, highlighting the role of EV subpopulations.
    Keywords:  Cardiovascular diseases; Endothelial-derived extracellular vesicles; Extracellular vesicles; Platelet-derived extracellular vesicles
    DOI:  https://doi.org/10.1186/s12967-025-06522-2
  4. Small. 2025 May 19. e2504761
      Atherosclerosis is a chronic vascular inflammatory disorder, and the cardiovascular disease resulting from it is the leading cause of death worldwide. Extracellular vesicles (EVs) are small membrane vesicles secreted by cells, playing a crucial role in regulating intercellular communication, signal transduction, and various pathophysiological processes. EVs have been shown to play a significant role in the progression and regression of atherosclerotic cardiovascular disease. Therefore, a comprehensive understanding of the role of EVs in the pathogenesis of atherosclerosis is essential for advancing knowledge in this field and driving the development of innovation of novel diagnostic and therapeutic strategies. This review summarizes the pathological roles of EVs in atherosclerosis, including their involvement in endothelial cell inflammation, the phenotypic transformation of vascular smooth muscle cells, macrophage activation, foam cell formation, and plaque thrombosis and rupture. Furthermore, it discusses innovative EV-based strategies for diagnosing and treating atherosclerosis. Finally, the challenges and prospects of translational research on EVs in atherosclerosis are discussed. This work aims to provide an EV-centered perspective on the diagnosis and treatment of atherosclerosis.
    Keywords:  atherosclerosis; cardiovascular diseases; extracellular vesicles; theranostic
    DOI:  https://doi.org/10.1002/smll.202504761
  5. J Agric Food Chem. 2025 May 22.
      In recent years, mammal-derived extracellular vesicles (EVs) have been widely used in studies on tissue repair and antiaging. Their therapeutic potential lies in mediating intercellular communication through the transfer of various bioactive molecules. As research on nanovesicles progresses, plant-derived nanovesicles (PDNVs) have attracted growing attention as a promising alternative. As an emerging cross-species regulatory "natural force", PDNVs have attracted considerable interest due to their excellent biocompatibility, low immunogenicity, and remarkable therapeutic effects in tissue injury and aging-related diseases. In this review, we examine the bioactive components, drug delivery potential, and functional mechanisms of PDNVs, and we summarize recent advances in their applications for tissue repair and antiaging. In addition, we systematically discuss the major challenges and limitations hindering the clinical translation and industrialization of PDNVs, and we propose five strategic approaches along with future research directions. This review aims to promote further investigation of PDNVs in regenerative medicine and enhance their potential for clinical application.
    Keywords:  antiaging; biomedicine applications; damage repair; exosomes; extracellular vesicles; plant-derived nanovesicles
    DOI:  https://doi.org/10.1021/acs.jafc.5c01547
  6. Int J Nanomedicine. 2025 ;20 6271-6288
      Acute kidney injury (AKI) has a high morbidity and mortality rate but can only be treated with supportive therapy in most cases. The diagnosis of AKI is mainly based on serum creatinine level and urine volume, which cannot detect kidney injury sensitive and timely. Therefore, new diagnostic and therapeutic molecules of AKI are being actively explored. Extracellular vesicles (EVs), secreted by almost all cells, can originate from different parts of the kidney and mediate intercellular communication between various cell types of nephrons. At present, numerous successful EV-based biomarker discoveries and treatments for AKI have been made, such as the confirmed diagnostic role of urine-derived EVs in AKI and the established therapeutic role of mesenchymal stem cell-derived EVs in AKI have been confirmed; however, these related studies lack a full discussion. In this review, we summarize the latest progression in the profound understanding of the functional role of EVs in AKI caused by various etiologies in recent years and provide new insights into EVs as viable biomarkers and therapeutic molecules for AKI patients. Furthermore, the current challenges and prospects of this research area are briefly discussed, presenting a comprehensive overview of the growing foregrounds of EVs in AKI.
    Keywords:  acute kidney injury; diagnostic biomarkers; extracellular vesicles; mesenchymal stem cells; therapeutic molecules
    DOI:  https://doi.org/10.2147/IJN.S519345
  7. Curr Osteoporos Rep. 2025 May 22. 23(1): 22
       PURPOSE OF REVIEW: Mechanical loading of bone is an important physical stimulus for bone tissue remodeling and adaptation. It is transmitted from the extracellular matrix all the way to the osteocyte nucleus via the extracellular matrix-integrin-cytoskeleton-nucleus system. Mitochondria are integral in sensing of mechanical loads to allow the cell to adapt to its environment. This review provides a background of mitochondrial distribution in osteocytes especially during mechanical loading, discussing the importance of mitochondrial distribution in osteocyte mechanosensitivity and mechanotransduction.
    RECENT FINDINGS: Mitochondria throughout the osteocyte are highly dynamic and provide essential metabolic and signal functions to regulate osteocyte morphology and function. They undergo the processes of fission and fusion accompanied by mitochondrial DNA distribution. The mitochondrial network structure and function in osteocytes can be regulated by mechanical loading. Interestingly, mitochondria can be transmitted by osteocytes into adjacent cells to communicate with them via tunneling nanotubes, migrasomes, and blebbisomes, causing changes in cell morphology and/or function. Mitochondrial distribution in or out osteocytes can be rearranged by physical and (bio)chemical signals via fission and fusion, as well as tunneling nanotubes, migrasomes, and blebbisomes. Mechanical loading-induced changes in mitochondria may drive signaling pathways of cell function in aging and diseases. More insights into interactions between neighbouring osteocytes and between osteocytes and other cell types would facilitate the development of new strategies to apply mitochondrial therapy for bone-related diseases.
    Keywords:  Cell communication; Mechanical loading; Mechanotransduction; Mitochondria; Mitochondrial distribution; Osteocytes
    DOI:  https://doi.org/10.1007/s11914-025-00918-1