bims-meprid Biomed News
on Metabolic-dependent epigenetic reprogramming in differentiation and disease
Issue of 2022‒03‒20
one paper selected by
Alessandro Carrer
Veneto Institute of Molecular Medicine

  1. Trends Cell Biol. 2022 Mar 14. pii: S0962-8924(22)00036-8. [Epub ahead of print]
      Gene transcription and cell metabolism are two fundamental biological processes that mutually regulate each other. Upregulated or altered expression of glucose metabolic genes in glycolysis and gluconeogenesis is a major driving force of enhanced aerobic glycolysis in tumor cells. Importantly, glycolytic and gluconeogenic enzymes in tumor cells acquire moonlighting functions and directly regulate gene expression by modulating chromatin or transcriptional complexes. The mutual regulation between cellular metabolism and gene expression in a feedback mechanism constitutes a unique feature of tumor cells and provides specific molecular and functional targets for cancer treatment.
    Keywords:  cancer; gene expression; gluconeogenesis; glycolysis; metabolism