bims-meprid Biomed News
on Metabolic-dependent epigenetic reprogramming in differentiation and disease
Issue of 2022–02–06
two papers selected by
Alessandro Carrer, Veneto Institute of Molecular Medicine
  1. A microbiome-macrophage-iron axis guides stressed hematopoietic stem cell fate.
  2. 2-HG modulates glioma macrophages via Trp metabolism.
  1. Cell Stem Cell. 2022 Feb 03. pii: S1934-5909(22)00009-1. [Epub ahead of print]29(2): 177-179
    A microbiome-macrophage-iron axis guides stressed hematopoietic stem cell fate.
    Francisco Caiado, Markus G Manz.
      The mammalian microbiota is a recently recognized regulator of hematopoiesis. In this issue of Cell Stem Cell, Zhang et al. (2022) show in mice that microbiota-derived butyrate enhances bone marrow macrophage erythrophagocytosis-dependent iron availability, which supports stress-induced hematopoietic stem cell differentiation and blood regeneration.
    DOI:  https://doi.org/10.1016/j.stem.2022.01.009
  2. Nat Cancer. 2021 Jul;2(7): 677-679
    2-HG modulates glioma macrophages via Trp metabolism.
    Marie Jo Halaby, Tracy L McGaha.
      
    DOI:  https://doi.org/10.1038/s43018-021-00231-7
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