bims-maitce Biomed News
on MAIT cells
Issue of 2024–04–14
one paper selected by
Andy E. Hogan, Maynooth University



  1. Am J Pathol. 2024 Apr 08. pii: S0002-9440(24)00125-1. [Epub ahead of print]
      Mucosal-associated invariant T (MAIT) cells are essential in defending against infection. Sepsis is a systemic inflammatory response to infection and a leading cause of death. The relationship between the overall competency of the host immune response and disease severity is not fully elucidated. This study identified a higher proportion of circulating MAIT17 with expression of IL-17A and RORγt in sepsis patients. The proportion of MAIT17 was correlated with the severity of sepsis. Single-cell RNA sequencing (scRNA-seq) analysis revealed an enhanced expression of lactate dehydrogenase A (LDHA) in MAIT17 in sepsis patients. Cell-culture experiments demonstrated that Phosphoinositide 3-kinase (PI3K)-LDHA signaling was required for RORγt expression in MAIT17. Finally, the elevated levels of plasma IL-18 promoted the differentiation of circulating MAIT17 in sepsis. In summary, this study reveals a new role of circulating MAIT17 in promoting sepsis severity and suggests the PI3K-LDHA signaling as a driving force in MAIT17 responses.
    Keywords:  IL-17; LDHA; RORγt; mucosal-associated invariant T cells; sepsis
    DOI:  https://doi.org/10.1016/j.ajpath.2024.03.010