bims-lycede Biomed News
on Lysosome-dependent cell death
Issue of 2026–07–19
two papers selected by
Sofía Peralta, Universidad Nacional de Cuyo
  1. Lysosomes and lysosomal dysfunction in ageing biology.
  2. Lysosome as a central hub in ferroptosis-driven pathologies.
  1. Nat Cell Biol. 2026 Jul 15.
    Lysosomes and lysosomal dysfunction in ageing biology.
    Matthew L Steinhauser, Yuan Liu, Stacey J Sukoff Rizzo, Bill B Chen, Toren Finkel, Jay Xiaojun Tan.
      Lysosomes are essential regulators of cellular homeostasis. Emerging evidence positions lysosomes as both vulnerable targets and active drivers of ageing biology. During ageing, lysosomes exhibit impaired biogenesis, defective acidification, reduced hydrolytic activity and compromised membrane integrity. These defects impair the clearance of damaged organelles and macromolecules and promote cellular stress responses, inflammageing and senescence, causing age-dependent functional decline across tissues. Lysosomal dysfunction has been increasingly linked to age-related diseases, including neurodegeneration, cardiometabolic disorders and increased susceptibility to infection, among others. Thus, lysosomal dysfunction is a hallmark of ageing that drives age-related pathology. Here we review recent progress in lysosomal biogenesis and quality control, discuss how lysosomes intersect with fundamental ageing mechanisms and evaluate emerging therapeutic strategies that target lysosomes to promote healthy ageing and potentially ameliorate age-associated pathologies.
    DOI:  https://doi.org/10.1038/s41556-026-02007-6
  2. Trends Mol Med. 2026 Jul 17. pii: S1471-4914(26)00169-3. [Epub ahead of print]
    Lysosome as a central hub in ferroptosis-driven pathologies.
    Siyu Li, Bavid Qiu, Xin Yi, Ding-Sheng Jiang.
      Ferroptosis is a unique form of programmed cell death that involves multiple organelles. Although traditionally viewed as a 'degradation workshop', accumulating evidence reveals that the lysosome serves as a central hub for iron metabolism and signal transduction, orchestrating the overall fate of cellular ferroptosis across spatiotemporal dimensions. In this review, we propose the concept of the 'lysosome-ferroptosis axis' and outline its roles in metabolic signaling, autophagy, and lysosomal membrane permeabilization. We further discuss the involvement of this axis in neurodegenerative, tumor, and cardiometabolic diseases, with the aim of providing new insights for targeted therapeutic strategies.
    Keywords:  cancer; cardiometabolic disorder; ferroptosis; lysosome; neurodegenerative disorder
    DOI:  https://doi.org/10.1016/j.molmed.2026.06.016
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