bims-librar 2018-10-28 papers

Issue of 2018–10–28
four papers selected by
Thomas Krichel, Open Library Society

J Clin Epidemiol. 2018 Oct 18. pii: S0895-4356(17)31330-6. [Epub ahead of print]

A Data-Sharing Agreement Helps to Increase Researchers' Willingness to Share Primary Data: Results from a Randomized Controlled Trial.

Joshua R Polanin, Mary Terzian.

BACKGROUND: Sharing individual participant data (IPD) among researchers, upon request, is an ethical and responsible practice. Despite numerous calls for this practice to be standard, however, research indicates that primary study authors are often unwilling to share IPD, even for use in a meta-analysis.
OBJECTIVES: This study sought to examine researchers' reservations about data sharing and to evaluate the impact of sending a data-sharing agreement on researchers' attitudes toward sharing IPD.
METHODS: To investigate these questions, we conducted a randomized controlled trial in conjunction with a Web-based survey. We searched for and invited primary study authors of studies included in recent meta-analyses. We emailed more than 1,200 individuals, and 247 participated. The survey asked individuals about their transparent research practices, general concerns about sharing data, attitudes toward sharing data for inclusion in a meta-analysis, and concerns about sharing data in the context of a meta-analysis. We hypothesized that participants who were randomly assigned to receive a data-sharing agreement would be more willing to share their primary study's IPD.
RESULTS: Results indicated that participants who received a data-sharing agreement were more willing to share their dataset, compared with control participants, even after controlling for demographics and pretest values (d = 0.65, 95% CI[0.39, 0.90]). A member of the control group is 24 percent more likely to share her dataset should she receive the data-sharing agreement.
CONCLUSIONS: These findings shed light on data-sharing practices, attitudes, and concerns and can be used to inform future meta-analysis projects seeking to collect IPD, as well as the field at large.

DOI: https://doi.org/10.1016/j.jclinepi.2018.10.006

Int J Med Inform. 2018 Nov;pii: S1386-5056(18)30621-X. [Epub ahead of print]119 94-102

Bring-your-own-device in medical schools and healthcare facilities: A review of the literature.

Khutsafalo Kadimo, Masego B Kebaetse, Dineo Ketshogileng, Lovie Edwin Seru, Kagiso B Sebina, Carrie Kovarik, Kutlo Balotlegi.

BACKGROUND: Enabling personal mobile device use through a bring-your-own device (BYOD) policy can potentially save significant costs for medical schools and healthcare facilities, as they would not always have to acquire facility-owned devices. The BYOD policy is also perceived as a driver for balancing user needs for convenience with institutional needs for security. However, there seems to be a paucity in the literature on BYOD policy development, policy evaluation, and evaluation of mobile device implementation projects.
OBJECTIVE: This review explored the literature to identify BYOD policy components (issues, interventions, and guidelines) that could potentially inform BYOD policy development and implementation in medical schools and healthcare facilities.
METHODS: A literature search on PubMed, Web of Science, and Ebscohost (Academic Search Premier, ERIC, CINAHL, and MEDLINE) was conducted using the following search terms and their synonyms: healthcare facilities, mobile devices, BYOD, privacy and confidentiality, and health records. We developed a review matrix to capture the main aspects of each article and coded the matrix for emerging themes. The database and hand search yielded 1 594 articles, 14 of which were deemed as meeting the inclusion criteria.
RESULTS: Several themes emerging from the analysis include: device management, data security, medical applications, information technology, education and/or curriculum, policy, and guidelines. The guidelines theme seems to provide a direction for BYOD policy development and implementation while the policy theme seems to be the comprehensive solution that synergizes BYOD implementation.
CONCLUSION: Rather than an approach of 'chasing' issues with interventions, a more feasible approach towards achieving a safe mobile device use environment is through the development of comprehensive BYOD policies that would balance users' need for convenience with organizational security and patient privacy. The paucity in peer-reviewed literature calls for robust research that uses socio-technical approaches to development and evaluation of BYOD policies in medical schools and healthcare facilities.

Keywords: Bring-your-own-device (BYOD); Healthcare facilities; Medical education; Mhealth; Mlearning; mobile devices

DOI: https://doi.org/10.1016/j.ijmedinf.2018.09.013

J Clin Epidemiol. 2018 Oct 18. pii: S0895-4356(17)30570-X. [Epub ahead of print]

Citation bias in the literature on dietary trans fatty acids and serum cholesterol.

Miriam J E Urlings, Bram Duyx, Gerard M H Swaen, Lex M Bouter, Maurice P A Zeegers.

OBJECTIVE: Balanced citations are a necessary condition for a sound development of scientific knowledge, whereas selective citations may bias scientific consensus. In this study, we assess which determinants influenced the likelihood of being cited in the literature on trans fatty acids and cholesterol.
STUDY DESIGN: We conducted a citation network analysis of the literature concerning trans fats and LDL- and HDL-cholesterol. Each publication was scored on various potential determinants of citation, such as study outcome, study design, sample size, journal impact factor and funding source. We applied random effect logistic regression to identify determinants of citation.
RESULTS: A network of 108 publications was identified, containing 5041 potential citation paths and 669 utilized citation paths. Reporting statistically significant results was found to be a strong predictor of citation, together with sample size, journal impact factor and the authority of the authors.
CONCLUSION: Within the literature on trans fat intake and cholesterol, selective citations are based on several grounds. Especially the effect of reporting significant results on citation requires special attention, since disproportionate attention is paid to publications suggesting a harmful effect of trans fat on cholesterol.

Keywords: Citation bias; cholesterol; citation network analysis; epidemiology; meta-research; trans fatty acids

DOI: https://doi.org/10.1016/j.jclinepi.2018.10.008

J Pharm Pharm Sci. 2018 ;21(1): 376-385

Research on the Scientific Evolution of the Flavonoid Agathisflavone.

Vanessa Cristina Meira De Amorim, Markley Silva Oliveira Júnior, Eduardo Muniz Santana Bastos, Victor Diogenes Amaral Da Silva, Silvia Lima Costa.

PURPOSE: Flavonoids are a group of secondary metabolites of the polyphenols class present in several plant species. Among them, the biflavonoid agathisflavone is of interest since it bears several biological effects that include: antiviral, antitumoral, antiprotozoal and neurogenic actions. In this sense, this study aims to use the important tool of scientific prospecting to assess the level of research development concerning the flavonoid agathisflavone.
METHODS: The experimental design was carried out through strategic reach with keywords on the PubMed (National Center for Biotechnology Information - NCBI) and Science Direct platforms. The articles were compiled and exported to Microsoft Office Excel 2007, where they were analyzed, stored and distributed in charts organized as to different countries, year of publication of scientific articles and journals RESULTS: The prospective research resulted in the identification of 81 scientific productions, published in several journals, submitted by different countries, in several areas of medical domain and in different years of publication over the last 50 years (1965 - 2018). It was also possible to investigate the advances in the study of agathisflavone for the development of new therapeutics.
CONCLUSION: Although agathisflavone has been known in the literature since at least 1969, only 23 of the eligible articles found evaluated its possible therapeutic effects. The demonstrated biological activities of agathisflavone range from antiprotozoal to neurogenesis and neuroprotection, however, the molecule needs to be better studied at the in vivo and human level.

DOI: https://doi.org/10.18433/jpps30103