bims-hypusi Biomed News
on Hypusine and eIF5A
Issue of 2023‒06‒18
one paper selected by
Sebastian J. Hofer
University of Graz

  1. Blood Cancer Discov. 2023 Jun 14. OF1-OF4
      SUMMARY: In this issue of Blood Cancer Discovery, Nakanishi et al. uncover a critical role for the elevated activity of the translation initiation factor eIF5A in the malignant growth of MYC-driven lymphoma. eIF5A is posttranslationally modified by hypusination through MYC oncoprotein-mediated hyperactivation of the polyamine-hypusine circuit, which may represent a promising therapeutic target because an enzyme of this circuit that is required for hypusinating eIF5A proved to be essential for lymphoma development. See related article by Nakanishi et al. (4).