Curr Opin Cell Biol. 2020 Apr 06. pii: S0955-0674(20)30044-2. [Epub ahead of print]63
194-203
Higher-order supramolecular complexes-dubbed signalosomes carry out key signaling and effector functions in innate immunity and inflammation. In this review, we present several recently discovered signalosomes that are formed either by stable protein-protein interactions or by dynamic liquid-liquid phase separation. Structural features of these signalosomes are highlighted to elucidate their functions and biological insights.