bims-evares Biomed News
on Evaluation of research
Issue of 2025–04–13
89 papers selected by
Thomas Krichel, Open Library Society



  1. Discov Oncol. 2025 Apr 04. 16(1): 463
      Cancer is a major public health and economic issue faced globally today, significantly affecting human health and life. Due to various constraints, exploring the causal relationship between risk factors and cancer is challenging and not exactly accurate. The advent of Mendelian randomization (MR) effectively addresses these issues, providing new avenues for exploring causal relationships. We downloaded literature related to the application of MR in cancer from the Web of Science Core Collection (WoSCC) from 2005 to October 21, 2024, limiting the document type to articles and the language to English, resulting in a total of 2058 articles. We downloaded them in plain text format and extracted information on countries, authors, institutions, keywords, journals, citation counts, and publication dates, utilizing VOSviewer, CiteSpace, and R language for bibliometric analysis. From 2005 to 2024, the number of publications on the application of MR in cancer has shown a growth trend. China was the most productive country (1305); the University of Bristol was the most prolific institution (213); Smith, George Davey published the most articles in this field (59) with a total citation count of 5344; the most prolific journal in this field is Scientific Reports (71). Chronic diseases and cancer, inflammation and cancer, and sex hormones and cancer are three hot topics in the current research on the application of MR in cancer. In the future, optimizing statistical methods, standardizing research processes, collecting data from a broader range of populations, expanding data scale, and integrating other research methods to enhance research quality will be the development trends of MR in cancer research. In summary, this study employed bibliometric methods to comprehensively analyze the literature on the application of MR in cancer over the past 20 years, evaluating the historical development, current applications, research hotspots, and future trends of MR in the field of cancer.
    DOI:  https://doi.org/10.1007/s12672-025-02226-7
  2. Int J Eat Disord. 2025 Apr 07.
       OBJECTIVE: This bibliometric study analyzed eating disorder research from 1975 to 2024, examining publication trends, research themes, and the relationship between public engagement and academic attention over five decades.
    METHODS: Data were collected from PubMed, Web of Science, APA PsycInfo, and CINAHL. Publication trends were analyzed, and leading journals were identified. Network analysis using VOSviewer identified thematic clusters, while a bump chart visualized changes in key research terms over time. Trends, associations, and influencing factors of public engagement and academic attention were assessed using Altmetric Attention Scores per Year (AASPY) and citations per year (CPY).
    RESULTS: A total of 101,993 publications were analyzed. Research output increased significantly, with the International Journal of Eating Disorders as the leading contributor. Six major research clusters were identified, and eight key terms (humans, female, anorexia nervosa, adult, adolescent, male, feeding and eating disorders, and child) remained dominant across all decades. AASPY and CPY increased over time but showed a weak correlation (R2 = 9.09%), suggesting that digital engagement was not strongly associated with scholarly attention. Studies on young adults and those published in multidisciplinary journals had higher online engagement, while research on female and young adult populations, as well as neuroscience, received greater academic attention.
    CONCLUSIONS: The findings highlight the sustained growth of research output, the persistence of core thematic areas, and the divergence between public engagement and academic attention. By examining trends from past to present, this study provides a basis for understanding research developments and their implications for future directions in eating disorder research.
    Keywords:  Altmetric Attention Score; bibliometric analysis; citation; feeding and eating disorders; public attention
    DOI:  https://doi.org/10.1002/eat.24436
  3. Discov Oncol. 2025 Apr 07. 16(1): 484
       BACKGROUND: Nanotechnology has great potential and advantages in the treatment of hepatocellular carcinoma (HCC), but the research trends and future directions are not yet clear.
    OBJECTIVES: Analyze the development trajectory, research hotspots, and future trends of nanotechnology and HCC research globally in the past 20 years, providing a more comprehensive and intuitive reference for researchers in this field.
    METHODS: Retrieve relevant literature on nanotechnology and HCC research in the Web of Science (WOS) Core Collection database, and conduct bibliometric analysis using software such as CiteSpace, VOSviewer, and SCImago Graphica.
    RESULTS: A total of 852 English publications meeting the criteria were retrieved from the WOS database, with an overall increasing trend in the number of publications and citation frequency over the years. China leads in the number of publications and international collaborations, followed by the USA and India. The most influential research institution is the Chinese Academy of Sciences, the most influential scholar/team is the Rahman, Mahfoozur team, and the journal with the most publications is the International Journal of Nanomedicine. A comprehensive analysis reveals that the current main research directions include new types of nanoparticles, targeted drug delivery systems, photothermal/photodynamic therapy, gene delivery systems, diagnostics, and imaging. It is anticipated that further collaboration among scholars, institutions, and countries will accelerate the development of nanotechnology in the field of HCC research.
    CONCLUSION: This study provides an in-depth analysis of the research status and development trends of nanotechnology in treating HCC from a bibliometric perspective, offering possible guidance for researchers to explore hot topics and frontiers, select suitable journals, and partners in this field.
    Keywords:  Bibliometrics; CiteSpace; Hepatocellular carcinoma; Nanotechnology; VOSviewer
    DOI:  https://doi.org/10.1007/s12672-025-02145-7
  4. Medicine (Baltimore). 2025 Apr 04. 104(14): e41890
      Through bibliometric analysis, trends in international acupuncture clinical development, key research areas, and current scientific issues were identified based on literature published from 2013 to 2022. Literature on acupuncture in clinical settings was retrieved and analyzed in this study utilizing the Web of Science database. A visualization analysis of the scientific landscape was performed using CiteSpace, VOSviewer, and GraphPad Prism. General statistics regarding the literature were examined, encompassing annual publication trends, citation frequencies, journal distributions, distributions across subject fields. Co-occurrence and cluster analyses of authors, countries, institutions, high-quality literature, and keywords were performed to explore the developmental trends, hotspots, and frontiers in acupuncture research comprehensively and intuitively. A total of 4554 studies were included, with an increasing trend in the number of publications related to the annual acupuncture Scientific Citation Index (SCI). The impact factors of the top 10 journals were mostly 1 to 3 points. The 10 most cited articles primarily concentrated on the use of acupuncture for pain-related disorders. Acupuncture and electroacupuncture are the dominant keywords, with terms such as "ischemic stroke" and "Alzheimer's disease" emerging from 2019 to 2022. From 2013 to 2022, the output of clinical SCI literature on acupuncture increased, acupuncture research gradually gained international recognition, and China gradually moved toward a dominant position. The most significant clinical research area of acupuncture is its application for analgesia, particularly through acupuncture and electroacupuncture. Future research directions may include the treatment of knee osteoarthritis, cognitive disorders, and assisted reproduction utilizing acupuncture.
    Keywords:  Acupuncture; CiteSpace; VOSviewer; bibliometrics; methodological
    DOI:  https://doi.org/10.1097/MD.0000000000041890
  5. Eur Arch Otorhinolaryngol. 2025 Apr 07.
       OBJECTIVE: Scientometric analysis helps to understand the research trends and identify top contributors, publishers, trends, and research topics. Laryngopharyngeal reflux has been a topic of interest in research and clinical practice. The literature on laryngopharyngeal reflux is evolving and a scientometric analysis will help us understand the trends better. The present study aimed to analyze published data to identify trends, top contributors, top institutions and countries, growth of publications, keywords and keyword co-occurrence.
    METHODS: The present study aims to analyze the evolution of Laryngopharyngeal reflux research using a scientometric analysis approach for publications from the Scopus database using keywords related to laryngopharyngeal reflux. Documents related to laryngopharyngeal reflux were identified for further analysis. Microsoft Excel and VosViewer were used to perform bibliometric analysis.
    RESULTS: A total of 7,327 hits were obtained, and after applying filter, 5637 studies were retained for further analysis. The results revealed an increase in publications on LPR, which surged after the early 2000s. The Unites States had the maximum research output, and the Journal of Voice had the highest number of publications. The keyword co-occurrence analysis helped identify five research themes on laryngopharyngeal reflux.
    CONCLUSION: The findings reveal a rising trend in laryngopharyngeal reflux, especially in recent years. The presence of international collaborations and a high volume of research will help bridge gaps, enable capacity building and improve understanding of LPR.
    Keywords:  Laryngopharyngeal reflux; Reflux; Scientometric analysis; Voice disorders
    DOI:  https://doi.org/10.1007/s00405-025-09381-1
  6. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2024 Dec 28. pii: 1672-7347(2024)12-1953-13. [Epub ahead of print]49(12): 1953-1965
       OBJECTIVES: Long noncoding RNAs (lncRNA) play important roles in the pathological processes of angiogenesis-related diseases such as cancer and diabetic retinopathy. This study aims to identify global research trends and hotspots in the field of lncRNAs in angiogenesis-related diseases and to explore future research directions.
    METHODS: Relevant literature published between 2012 and 2022 was retrieved from the Web of Science Core Collection (WoSCC). A total of 1 516 articles on lncRNAs and angiogenesis-related diseases were included for bibliometric analysis. CiteSpace and VOSviewer were used to analyze publication countries, institutions, journals, authors, co-cited references, and key words.
    RESULTS: The number of publications in this field has shown a steadily increasing trend from 2012 to 2022, peaking in 2021. China has the highest number of publications, while the United States ranked highest in centrality. Nanjing Medical University was the most prolific institution. Liu Y was the most productive author, while Wang Y ranked first in co-citation frequency. Cell was the most frequently cited journal. The latest terms of burst key words were vascular remodeling, dysfunction, heart, target, suppress, and pulmonary arterial hypertension.
    CONCLUSIONS: From 2012 to 2022, research on lncRNAs in angiogenesis-related diseases has grown significantly. China leads in publication volume, while the United States holds the most academic influence. Emerging research hotspots such as vascular remodeling and dysfunction point to key directions for future research.
    Keywords:  CiteSpace; VOSviewer; angiogenesis-related diseases; bibliometrics; long noncoding RNA
    DOI:  https://doi.org/10.11817/j.issn.1672-7347.2024.240138
  7. Front Immunol. 2025 ;16 1559670
      Curcumin has a clear immunopharmacological effect and plays an important role as an immune agent in various immune diseases and tumor immunotherapy. To comprehensively and scientifically clarify and reflect the development process, current status, and research trends of curcumin in the field of immune regulation, and to provide reliable insights for discipline development strategies and future research expansion, this study systematically analyzes 3939 valid articles related to curcumin and immunity published between 2004 and 2024 from the Web of Science database. Using Citespace and R-bibliometrix software for bibliometric analysis, we create visual knowledge maps from multiple dimensions including overall publication output, influential research entities, highly cited papers, research topics and hotspots. The results indicate that the overall number of publications and citations is currently in a rapid development phase. China occupies a core position in this research field but has low collaboration intensity. The Egyptian Knowledge Bank (EKB) is the institution with the highest publication volume. Moreover, cluster analysis reveals that research hotspots are gradually shifting from fundamental pathology to topics involving broad social and environmental influences. The top five keywords with the most explosive citations-curcumin, inflammation, apoptosis, oxidative stress, and cancer-represent the most focused and influential research topics. Currently, curcumin immunology has developed a diversified research perspective, accumulating significant research in the areas of active substance basis, pharmacological activity, anti-inflammatory, and anti-cancer studies. The thematic evolution trends and keywords related to curcumin's immunological mechanisms summarized in this article provide insights and guidance for future research directions.
    Keywords:  Citespace; anti-cancer; bibliometric analysis; curcumin; immunity
    DOI:  https://doi.org/10.3389/fimmu.2025.1559670
  8. Drug Des Devel Ther. 2025 ;19 2577-2596
       Background: Tuberculosis (TB) poses a serious threat to public health, particularly owing to the increase in multidrug-resistant tuberculosis (MDR-TB) and extremely drug-resistant tuberculosis (XDR-TB); thus, there is an imperative need for novel treatments to tackle this issue. Decaprenylphosphoryl-β-D-ribose 2'-epimerase (DprE1) is essential for mycobacterial cell wall integrity and viability. As no relevant bibliometric study has been reported, we performed bibliometric and visual analyses to depict the knowledge framework of research related to the involvement of DprE1 in TB.
    Methods: Relevant studies were sourced from the Web of Science Core Collection database. VOSviewer, CiteSpace, and bibliometrics (http://bibliometric.com/) were used to construct networks based on an analysis of journals, countries, funding, institutions, authors, references, and keywords.
    Results: A total of 184 publications were retrieved; the total citations were 3405 times and the mean citation was 17.28 per article. The annual number of publications on DprE1 in TB has shown a significantly increasing trend. The European Journal of Medicinal Chemistry is the most published journal, with 19 articles. Lu Yu and Bin Wang contributed the most prolific authors with 18 articles. Stratified by the number of publications, India was the most prolific country that cooperated closely with the USA, UK, Japan, and United Arab Emirates. Burstness analysis of references and keywords showed that the developing research trends in this field mainly woven around "Mtb", "DprE1" and "inhibitors" during the past years.
    Conclusion: A systematic bibliometric study indicates that DprE1 remains a focal point in the anti-TB domain. These results can serve as a data-driven reference for future research and offer precise insights into the development of anti-TB agents associated with DprE1. To the best of our knowledge, this study is the first to comprehensively investigate DprE1 in TB by means of bibliometric analysis.
    Keywords:  CiteSpace; DprE1 inhibitors; R-bibliometrix; VOSviewer; drug target; tuberculosis
    DOI:  https://doi.org/10.2147/DDDT.S515049
  9. Braz Oral Res. 2025 ;pii: S1806-83242025000102550. [Epub ahead of print]39 e037
      Objectively evaluating an individual's capacity for food fragmentation (masticatory performance) is crucial for understanding oral physiology and dental rehabilitation processes. Our aim was to conduct a bibliometric analysis of the literature focusing on masticatory performance. We conducted a survey in Web of Science up to August 31, 2024, applying specific category filters. Two calibrated reviewers manually tabulated the data, extracting information on title, authorship, keywords, institutions, countries, number of citations, year of publication, journal title, study design, masticatory test, population, and dentition status. VosViewer software generated collaborative network maps, while JAMOVI was used to perform ANOVA and Poisson regression analyses. The selection process resulted in 814 articles published between 1950 and 2024, with a recent increase to at least 50 articles per year. The average impact factor was 3.16, with around 30 citations per article. Citations were significantly influenced by the masticatory performance technique, publication year, and journal impact factor. The comminution test was the most prevalent (n = 411). Most studies focused on adults (n = 420) and older adults (n = 361), in which natural dentition (n = 404) and complete dentures (n = 214) were the most widely assessed parameters. The most frequent study designs were cross-sectional (n=489) and prospective (n = 145). The leading countries were Japan (n=202), Brazil (n=134), and the Netherlands (n = 69), and the Journal of Oral Rehabilitation was the most recurrent journal (n = 162). This study highlights the growing interest in evaluating masticatory performance, with a significant increase in publications over the years. This study highlights the need for further research involving children and longitudinal study designs, as well as studies evaluating rehabilitations with removable partial denture and implant-supported prostheses.
    DOI:  https://doi.org/10.1590/1807-3107bor-2025.vol39.037
  10. Int J Oral Maxillofac Implants. 2025 Apr 08. 40(2): 171-180
       PURPOSE: To identify the top-cited articles in the field of sinus augmentation and to analyze the different bibliometric variables that impacted the citation of articles.
    MATERIALS AND METHODS: A search was conducted in the Web of Science database and sorted to find articles that were cited at least 100 times. The articles were then screened by two independent investigators (S.S. and K.C.M.) for inclusion. The included articles were analyzed to generate (1) keyword and title word maps using the VOS viewer program, (2) author timelines and contributions using Bibliometrix, and (3) citation analysis data using the HistCite software (Informer Technologies). Then the data were analyzed for individual variables affected by citation counts using Quasi-Poisson regression, Wilcoxon signed-rank test, and Fisher's exact test.
    RESULTS: A total of 162 articles were included in the analysis. The number of references in each article was directly proportional and the journal impact factor and number of pages in the included articles were inversely proportional to the number of citations (P < .05). Note that authors from the USA had the highest number of publications within the collection.
    CONCLUSIONS: The top-publishing authors, countries, keywords, and title words were identified. It was observed that the number of references, the journal impact factor, and the number of pages of the included articles significantly impacted citation counts obtained by a given article.
    Keywords:  bibliometric analysis; biomaterials; sinus augmentation; sinus elevation
    DOI:  https://doi.org/10.11607/jomi.10958
  11. Front Med (Lausanne). 2025 ;12 1555676
       Background: Thyroid disease continues to be one of the most prevalent disease groups worldwide, with its frequency and distribution being impacted by numerous factors. Significant progress has been achieved in recent years in thyroid nodules, largely due to the advent of novel detection and diagnostic techniques. This study aims to scrutinize the top 100 most frequently cited articles in thyroid nodule research, utilizing bibliometric analysis to identify trends, highlight critical focal points, and lay a groundwork for forthcoming investigations.
    Methods: A comprehensive literature search was carried out using the SCI-E database, and all the recorded results were downloaded in plain text format for detailed analysis. The key terms analyzed with VOSviewer 1.6.18, CiteSpace 6.3r1, bibliometrix in R Studio (v.4.4.1), and Microsoft Excel 2021 software include country, institution, author, journal, and keywords.
    Results: The publication timeframe extends from 1 January 2003 to 31 December 2021, reaching a peak citation count of 9,100. Notably, the United States leads in the number of published articles, with Harvard University standing out as a prestigious institution. These articles were featured in 45 diverse journals, with THYROID leading in publication volume. Nikiforov Yuri E. was the most prolific first author, appearing 10 times. Keyword analysis highlighted traditional research themes such as "fine needle aspiration," "carcinogens," and "management." However, "deep learning" has surfaced as a significant area of focus in recent studies.
    Conclusion: This study has extracted the bibliometric characteristics of the top 100 most-cited articles pertaining to TNs, providing an invaluable reference for upcoming studies. Through meticulous analysis, it has been determined that the primary research concentrations encompass the diagnosis of benign or malignant TNs, the management of TNs, and the subsequent monitoring of TNs, with deep learning emerging as a pivotal area of exploration.
    Keywords:  CiteSpace; VOSviewer; bibliometric analysis; bibliometrix; thyroid nodules
    DOI:  https://doi.org/10.3389/fmed.2025.1555676
  12. Front Oncol. 2025 ;15 1506778
       Background: Nasopharyngeal carcinoma (NPC) is a malignant tumor characterized by distinct geographic and pathological features. Enhancing diagnostic accuracy and timeliness in NPC is crucial for clinical implications. Radiomics has demonstrated significant potential in the clinical management of NPC. Nonetheless, a paucity of bibliometric studies has systematically examined the existing literature in th is domain. The objective of this study was to assess the current landscape and project future trends in NPC research.
    Methods: This study conducted a search on English-language literature concerning the application of radiomics within the field of nasopharyngeal carcinoma (NPC) research from January 2015 to July 1, 2024, utilizing the Web of Science Core Collection (WoSCC) database. Bibliometric and visual analyses were performed using VOSviewer and CiteSpace software on publications related to countries/regions, authors, journals, references, and keywords.
    Results: A total of 311 documents were retrieved, yielding 229 eligible documents after screening, comprising 209 articles and 20 reviews. Annual publications showed an upward trend, while citations revealed a generally declining trend. Notably, China contributed the most publications (n=175). Tian Jie and Dong Di each published 13 papers, and Zhang B was the most frequently co-cited author. Frontiers in Oncology published the most articles (n=25), and the International Journal of Radiation Oncology Biology Physics had the highest citation count (n=331). Sun Yat-sen University led institutional publications (n=39). The radiomics research in NPC focuses on survival prediction, texture analysis, and distant metastasis, and may guide future research directions.
    Conclusion: The application of radiomics in NRC is growing annually, as indicated by bibliometric analysis. Radiomics has enhanced the precision of preoperative diagnosis, prediction, and prognosis in NRC. Bibliometric findings offer insights into radiomics research trends. However, creating extensive NPC datasets and bridging the research-to-clinical gap pose significant challenges. Future research should focus on these areas to advance the development.
    Keywords:  bibliometrics; clinical decision-making; nasopharyngeal carcinoma; prognosis prediction; radiomics
    DOI:  https://doi.org/10.3389/fonc.2025.1506778
  13. Front Mol Biosci. 2025 ;12 1545109
       Background: Receptor activator of nuclear factor kappa-B ligand (RANKL) plays a critical role in bone metabolism and the pathogenesis of osteoporotic fractures. This study aims to conduct a bibliometric analysis of global research pertaining to RANKL and osteoporotic fractures to identify key trends, influential studies, and collaborative networks.
    Methods: A literature search was conducted to identify articles found in the Web of Science Core Collection database regarding RANKL and osteoporotic fractures from 2001 to 2024. A bibliometric analysis was performed using VOSviewer, CiteSpace, and R 4.3.3 for the publication volume, country and institution contributions, journal impact, author influence, and research hotspots.
    Results: A total of 214 articles were analyzed. Publication rates have steadily increased, with a peak of 21 papers in 2020. The U.S., China, and South Korea were the top contributing countries, and leading institutions included Harvard University and Dankook University. The Journal of Bone and Mineral Research, Osteoporosis International, and Bone were the journals of highest impact. At the level of authors, Heiss-Christian published the highest number and Christiansen-Claus had the strongest citation impact (1,368 citations). Research evolved from basic biological mechanisms (2001-2010) through clinical applications (2011-2017) to recent renewed interest in fundamental RANKL biology (2018-2024). Key research hotspots included postmenopausal osteoporosis, bone mineral density, and osteoclast differentiation, with emerging focus on RANKL's role beyond skeletal metabolism.
    Conclusion: This bibliometric analysis provides a comprehensive overview of RANKL research in osteoporotic fractures, highlighting key priorities for future investigation. Future studies should prioritize understanding RANKL's broader physiological roles, developing better predictive markers, and optimizing personalized treatment strategies.
    Keywords:  RANKL; bibliometric analysis; bone metabolism; osteoclast differentiation; osteoporotic fractures
    DOI:  https://doi.org/10.3389/fmolb.2025.1545109
  14. Front Pharmacol. 2025 ;16 1519000
       Background: Ferroptosis is a newly identified type of iron-dependent cell death that characterized by an increase in intracellular iron ions, which disrupt the balance of the cellular lipid peroxidation system, causing lipid peroxidation and ultimately resulting in cell death. Interestingly, ferroptosis is modulated by hypoxia and plays a role in hypoxia-related diseases. Therefore, we performed a bibliometric review of the Web of Science Core Collection (WoSCC) database to investigate the link between ferroptosis and hypoxia from January 2013 to December 2023.
    Method: The core collection within the Web of Science bibliographic index was consulted to extract relevant articles and reviews. Data on publications, countries, institutions, authors, journals, citations, and keywords in the included studies were systematically analyzed using Microsoft Excel 2019 and CiteSpace 6.3.R1 software.
    Result: A comprehensive analysis and visualization of 472 research papers on ferroptosis under hypoxic conditions published between 2013 and 2023 revealed emerging research hotspots and trends. Initially, a scarcity of studies existed in this field. However, this was succeeded by a significant increase in research interest in subsequent years, culminating in a peak of 204 publications in 2023. Research in this field focused primarily on the Asian region. Notably, research hotspots include diseases related to hypoxia, treatment therapy and pathogenesis. Among the researchers in this field, Supuran emerged as the most prolific author. Wuhan University was the leading institution in terms of research output, and China was the most prolific country in this area of study. Among the top ten journals ranked by the number of publications, nine were classified as Q1, indicating the high level of credibility of these studies. The research conducted by Stockwell et al., featured in the journal "Cell," currently has the most citations. Present scholarly pursuits are primarily focused on comprehending the mechanisms through which interventions affect hypoxia-related diseases through the ferroptosis pathway, as well as on probing and pinpointing prospective treatment targets.
    Conclusion: This study highlights key areas of interest and emerging trends in ferroptosis research in the presence of hypoxic conditions, thus providing valuable insights for future directions of exploration for the diagnosis and treatment of hypoxia-related diseases.
    Keywords:  bibliometric analysis; citespace; ferroptosis; hotspot; hypoxia
    DOI:  https://doi.org/10.3389/fphar.2025.1519000
  15. J Child Neurol. 2025 Apr 10. 8830738251328435
      This study presents a bibliometric analysis of cerebellar mutism syndrome (CMS), a severe postoperative complication in pediatric patients with posterior fossa tumors. A total of 445 publications were included in the study from a Web of Science query done on October 18, 2024. Publication output has steadily increased with research concentrated in developed nations, particularly the United States, which leads in publications and citations. Since 2020, developing nations in Africa, Latin America, and Asia have started to contribute more. The United Kingdom leads in collaboration. St Jude Children's Research Hospital is the top contributor. Regional collaboration is notable in Nordic institutions, Benelux institutions, and Italian institutions. International collaborations with institutions from developing nations, although still low, are increasing. Child's Nervous System is the leading journal. Recent keyword trends focus on surgical techniques, imaging modalities, and long-term outcomes. This bibliometric analysis provides an overview of CMS research, identifying key trends, collaborations, and gaps in the field.
    Keywords:  bibliometric analysis; cerebellar mutism syndrome; pediatrics; posterior fossa tumors; postoperative complications
    DOI:  https://doi.org/10.1177/08830738251328435
  16. Int Ophthalmol. 2025 Apr 10. 45(1): 152
       PURPOSE: To characterize current global status and frontiers in the field of vitreous floaters research.
    METHODS: The Web of Science Core Collection was used to retrieve the international scientific publications on vitreous floaters from 1999 to 2023. Scientometric data were analyzed and visualized using VOSviewer (1.6.18 Edition) and CiteSpace (6.3.R1).
    RESULTS: A total of 547 articles with 8940 citations were identified. The annual number of publications and citations dramatically increased during the period. The USA was the most productive country with 26.33% of the total articles and 40.44% of the total citations. The USA collaborated more frequently with countries including China and Japan. The most productive affiliation was University of California System and the most productive author was Sebag Julia from the USA. Retina and BMC Ophthalmology published the highest percentage of articles (4.94%) while American Journal of Ophthalmology received the most citations (6.66%). The most frequent subject category was "Ophthalmology" (n = 356, 52%). "Vitrectomy", "vitreous floaters", "uveitis", "vitreous opacity", and "YAG vitreolysis" were the top 5 frequent keywords. The efficacy and safety of management for vitreous floaters turned out to be a recent research hot spot, especially the pharmacologic vitreolysis agents and Nd:YAG laser vitreolysis.
    CONCLUSIONS: The optimized treatment of vitreous floaters emerged as a research hot spot. This study provides a broad insight of the status and frontiers in vitreous floaters, which might guide future research direction in this field.
    Keywords:  Bibliometric analysis; Ophthalmology; Publication productivity; Vitreous floater
    DOI:  https://doi.org/10.1007/s10792-025-03492-8
  17. Int J Health Care Qual Assur. 2025 Apr 15.
       PURPOSE: The study examines worldwide public health insurance and ageing studies. This was accomplished by doing a thorough bibliometric analysis of publications published between 2002 and 2022 (till 31st May), which includes 479 articles for the analysis.
    DESIGN/METHODOLOGY/APPROACH: This study used the Web of Science database to analyse the vast quantity of data from the journals referenced above. VOSviewer creates network maps, keyword concurrences and cross-country co-authorship. The research analyses parameters like article distribution by year and citation frequency to determine top publications. After that, co-authorship, country co-authorship and keyword co-occurrence bibliometric network maps are shown.
    FINDINGS: The finding of the study reveals that the year 2020 is the most productive year for publication; BMJ Open is referred to as the most productive journal in this area, and "Depression in the Elderly" is the most referenced paper. The US has published the highest number of articles. We've seen 21 authors work with "Akishita and Ishizaki". The USA is the most collaborative author with other countries and conducted a keywords-based cluster analysis in which "Public health insurance, older adults and long-term care" are the most frequent keywords in this domain.
    ORIGINALITY/VALUE: This article aligns with the current literature on elderly public health insurance. The authors utilize bibliometric analysis to provide a more comprehensive and robust understanding of this area. Those interested in conducting further research in this field can use the findings of this study as a guide.
    Keywords:  Bibliometric analysis; Elderly; Public health insurance; Public health services; VOSviewer and universal health coverage (UHC)
    DOI:  https://doi.org/10.1108/IJHCQA-03-2023-0019
  18. Adv Clin Exp Med. 2025 Apr 11.
       BACKGROUND: Mitochondrial dynamics is an important field in cell biology, encompassing mitochondrial fission and fusion. The balance between fission and fusion is responsible for the stability of the mitochondrial network and can be a regulator of mitochondrial function. Recent studies have emphasized that an imbalance in mitochondrial dynamics is the root cause of dysfunction and is involved in various stages, such as oxidative stress, inflammation and apoptosis. Reversing this imbalance can effectively alleviate disease conditions. Although the importance of mitochondrial dynamics has been widely recognized, there is still a lack of literature on the qualitative and quantitative description and analysis of advances in this field.
    OBJECTIVES: This study is a bibliometric analysis of research trends, collaboration networks and thematic evolution in mitochondrial dynamics from 2000 to 2023.
    MATERIAL AND METHODS: Using the Web of Science Core Collection (WoSCC) database, we performed a bibliometric review, applying VOSviewer and CiteSpace to visualize and analyze publications, citations, collaborations, and key word trends.
    RESULTS: We analyzed 332 publications, identifying China and the USA as leaders in research output and international collaborations. Significant contributions were made by institutions like Chiang Mai University and the California Institute of Technology (Caltech), with major research shifts from basic mitochondrial functions to roles in diseases like Alzheimer's and cardiovascular disease.
    CONCLUSION: Mitochondrial dynamics research has expanded, with increasing attention to its role in disease mechanisms. Future research should further explore these connections, potentially leading to innovative treatments.
    Keywords:  CiteSpace; Science Citation Index; VOSviewer; bibliometrics; mitochondrial dynamics
    DOI:  https://doi.org/10.17219/acem/196720
  19. J Act Sedentary Sleep Behav. 2023 Jul 01. 2(1): 13
       OBJECTIVES: No citation analysis has examined peer-reviewed sedentary behaviour research articles, which is needed to assess the impact of this research and identify knowledge gaps. Therefore, this study aimed to identify the 100 most cited sedentary behaviour articles and examine their bibliometric characteristics.
    METHODS: All databases indexed in the Web of Science database were searched in October 2022, and bibliometric characteristics of the studies, irrespective of the publication year, were imported and calculated. Descriptive statistics and visualisations by the VOSviewer were used for the presentation of bibliometric characteristics.
    RESULTS: The 100 most cited articles received 49,062 citations in total, with a median citation density of 32.5 citations per article per year. The majority of included articles were reviews (n = 48; 22,856 citations), focused on adults (58%; 26,809 citations) and reported on the relationship of sedentary behaviour with health (n = 64; 34,598 citations); more specifically they focused on anthropometric indices (28%), metabolic health (24%), and mortality (23%). The United States was ranked first in terms of the overall for most cited articles. However, Australia was ranked first for institutions and authors contributing to the most cited sedentary behaviour articles.
    CONCLUSIONS: Papers published after 2007 were predominant in the list of 100 most cited sedentary behaviour papers, as were those focusing on associations with physical health outcomes and those focusing on adults. While original articles were cited more, discussion papers had more impact on the field as they received more citations in less time. Research examining associations between sedentary behaviour and health was cited more. The field is dominated by contributions from high-income countries.
    Keywords:  Activity behaviour; Lifestyle behaviour; Publications; Sedentary time; Sitting time
    DOI:  https://doi.org/10.1186/s44167-023-00022-8
  20. Front Cardiovasc Med. 2025 ;12 1492051
       Objectives: Noise pollution has become an increasingly severe environmental issue in modern society and has been recognized for its adverse effects on cardiovascular diseases. Hypertension induced by noise exposure has garnered significant research interest and a large quantity of studies have been conducted. This study aims to employ bibliometric methods to comprehensively review the literature on the relationship between noise exposure and hypertension and to analyze the current state of research by identifying key areas of focus while also exploring future trends in this field.
    Methods: The bibliometric analysis was conducted using the Web of Science Core Collection (WoSCC) database. The search query included terms related to noise pollution and hypertension. The timeframe for the search was from 2003 to 2023. Data analysis and visualization were performed using VOSviewer, CiteSpace, Scimago Graphica, and Rtools, focusing on publication trends, citation metrics, explosive intensity, and collaborative networks. Pajek was used to adjust pictures.
    Results: The bibliometric analysis showed a notable rise in research output on the relationship between noise pollution and hypertension. The United States led in the number of publications, with China and Germany coming next. The study identified several key contributors, with Muenzel Thomas being the most prolific author, followed by Daiber Andreas and Pershagen Goran. Institutionally, Johannes Gutenberg University Mainz emerged as the leading institution in terms of publications, followed by Karolinska Institute. Collaborative networks among institutions highlighted significant international cooperation, with extensive collaborations observed, particularly between European and North American institutions. The study also pinpointed research hotspots and emerging trends through keyword analysis. Key areas of focus included the mechanisms linking noise exposure to hypertension, the impact of noise on cardiovascular health, and the role of environmental stressors.
    Conclusions: This study advances our understanding of noise-induced hypertension's physiological and biological mechanisms, emphasizing the need for continued research. The research underscores the necessity of addressing noise pollution as a significant public health concern.
    Keywords:  CiteSpace; VOSviewer; bibliometrics; hypertension; noise
    DOI:  https://doi.org/10.3389/fcvm.2025.1492051
  21. Front Oncol. 2025 ;15 1552914
       Background: Bevacizumab is a primary focus in the clinical application and research of metastatic colorectal cancer (mCRC) patients. This study aims to analyze publications on bevacizumab and CRC to explore and identify the trends and frontiers of this field.
    Methods: We collected 4,164 articles on bevacizumab and CRC from the Web of Science Core Collection (WoSCC). CiteSpace, VOSviewer, R-bibliometrix, and Microsoft Excel were utilized for analysis and visualization.
    Results: The United States, Japan, and China are the leading countries in this field. The National Cancer Institute and the University of Pisa share the top position for the highest number of publications. Personalized therapy, innovative combination treatments, mechanisms of resistance, and new drug development are enduring focal points and future research directions.
    Conclusions: This study provides the first bibliometric analysis of research on bevacizumab and CRC, revealing the current status and future directions of this field.
    Keywords:  VOSviewer; bevacizumab; bibliometric analysis; citespace; colorectal cancer
    DOI:  https://doi.org/10.3389/fonc.2025.1552914
  22. Hum Vaccin Immunother. 2025 Dec;21(1): 2488551
      Cancer seriously threatens the lives and health of people worldwide, and exosomes seem to play an important role in managing cancer effectively, which has attracted extensive attention from researchers in recent years. This study aimed to scientifically visualize exosomes research in cancer (ERC) through bibliometric analysis, reviewing the past, summarizing the present, and predicting the future, with a view to providing valuable insights for scholars and policy makers. Researches search and data collection from Web of Science Core Collection and clinical trial.gov. Calculations and visualizations were performed using Microsoft Excel, VOSviewer, Bibliometrix R-package, and CiteSpace. As of December 1, 2024, and March 8, 2025, we identified 8,001 ERC-related publications and 107 ERC-related clinical trials, with an increasing trend in annual publications. Our findings supported that China, Nanjing Medical University, and International Journal of Molecular Sciences were the most productive countries, institutions, and journals, respectively. Whiteside, Theresa L. had the most publications, while Théry, C was the most co-cited scholar. In addition, Cancer Research was the most co-cited journal. Spatial and temporal distribution of clinical trials was the same as for publications. High-frequency keywords were "extracellular vesicle," "microRNA" and "biomarker." Additional, "surface functionalization," "plant," "machine learning," "nanomaterials," "promotes metastasis," "engineered exosomes," and "macrophage-derived exosomes" were promising research topics. Our study comprehensively and visually summarized the structure, hotspots, and evolutionary trends of ERC. It would inspire subsequent studies from a macroscopic perspective and provide a basis for rational allocation of resources and identification of collaborations among researchers.
    Keywords:  Cancer; bibliometric analysis; exosomes; visualization analysis
    DOI:  https://doi.org/10.1080/21645515.2025.2488551
  23. Clin Res Hepatol Gastroenterol. 2025 Apr 08. pii: S2210-7401(25)00075-0. [Epub ahead of print] 102595
       BACKGROUND: Pancreatic cancer (PC) is a major global health challenge, with rising incidence and mortality rates, particularly in high-socio-demographic index regions. Given its high mortality and significant morbidity, research on patient quality of life (QoL) has gained momentum, addressing symptom burdens, psychological distress, and treatment-related outcomes. Bibliometric analysis provides a valuable approach to mapping research trends, identifying key contributors, and forecasting future directions.
    OBJECTIVE: This study aimed to map global research on QoL in pancreatic cancer patients, highlighting key findings, challenges, and future directions through bibliometric analysis over the past two decades.
    METHODS: Data for this study were collected from the Web of Science Core Collection (WoSCC) database, using specific search strategies to retrieve relevant documents on the quality of life in pancreatic cancer patients. The data were analysed using the Bibliometrix R package to create knowledge maps and visualize research trends, collaborations, and emerging hotspots in the field.
    RESULTS: A total of 819 articles on pancreatic cancer and quality of life were identified, with an average citation count of 47.13 per article, highlighting moderate academic impact. The research revealed a growing trend in collaborative efforts, with an average of 9.42 co-authors per article and 16% international collaborations. The United States emerged as the leading contributor, with 203 publications and the highest citation count, followed by France and the United Kingdom.
    CONCLUSION: This bibliometric analysis highlights the growing volume of pancreatic cancer and quality of life research, with a steady annual growth rate of 6.9% and increasing collaboration, especially from the United States. However, despite the rising number of publications, a decline in citation impact for recent studies suggests a need for continued innovation in therapeutic strategies to improve clinical outcomes.
    Keywords:  Bibliometric analysis; Network analysis; Pancreatic cancer; Quality of Life; Surgery
    DOI:  https://doi.org/10.1016/j.clinre.2025.102595
  24. Ann Med Surg (Lond). 2025 Apr;87(4): 2035-2048
       Background: Umbrella review studies have become increasingly vital in evidence synthesis, offering a comprehensive overview by analyzing multiple systematic reviews and meta-analyses. This bibliometric study aimed to delineate the growth and thematic evolution of umbrella reviews within evidence-based medicine, illuminating their integral role in synthesizing high-level evidence.
    Methods: Utilizing the Web of Science Core Collection, we performed a search for publications on umbrella reviews, identifying relevant articles through a refined strategy. Analytical tools including VOS Viewer and CiteSpace were employed to visualize connections and trends among the gathered data, converting intricate bibliometric information into comprehensible visual maps.
    Results: Our search yielded 2965 pertinent publications, highlighting a marked growth in research output, particularly from 2010 to 2023. The United States, United Kingdom, and China were predominant in this field, with leading institutions like King's College London and the University of Toronto at the forefront. The analysis identified major journals such as BMJ Open and PLOS One as key publishers. Co-citation and keyword analysis revealed current research focuses, with recent trends emphasizing COVID-19 and mental health. The study also uncovered a robust international collaboration network, underscoring the global impact of umbrella reviews.
    Conclusion: This bibliometric analysis confirms the expanding influence and utility of umbrella reviews in medical research and decision-making. By charting the evolution and current trends in this field, our study not only showcases the geographical and institutional distribution of research but also guides future scholarly efforts to advance evidence synthesis methodologies.
    Keywords:  bibliometric analysis; evidence synthesis; meta-analysis; research trends; scientific publication pattern; systematic reviews; umbrella reviews
    DOI:  https://doi.org/10.1097/MS9.0000000000003034
  25. Front Immunol. 2025 ;16 1550988
       Introduction: Breast cancer is the most common malignant tumor among women worldwide, and the tumor microenvironment (TME) has become a hot research field in contemporary oncology. Understanding the TME is essential for elucidating the mechanisms of breast cancer progression and identifying novel therapeutic targets for metastasis and recurrence. This study performed a bibliometric analysis of TME research for breast cancer, providing a comprehensive overview of current research hotspots, development trends, and directions.
    Methods: We retrieved for literature on TME for breast cancer published during 2014-2023 from the Web of Science database and performed bibliometric analysis. CiteSpace was used for co-citation analysis of references to assess the evolution and bursts in the knowledge base. VOSviewer was used for co-occurrence analysis of author keywords, countries/regions, institutions, and authors to reveal the knowledge structure and collaborative networks in this research area. Thematic evolution trends were analyzed using the bibliometrix package to reveal research hotspots, thematic evolution and dynamic changes of this research.
    Results: A total of 9683 documents were included in this study, and the keyword co-occurrence analysis displayed five clusters: immunotherapy, metastasis, diagnosis and prognosis, metabolic regulation, and therapeutic approaches, with the first two keywords, immunotherapy and metastasis, being the most frequently mentioned. The most productive country/region, institution, and author were China (3266 publications), Shanghai Jiao Tong University (208 publications), and Takahashi, Kazuaki (37 publications).
    Conclusion: In breast cancer TME research, cancer-associated fibroblasts have attracted widespread attention, while cancer immunotherapy has emerged as a key focus in contemporary studies.
    Keywords:  bibliometric; breast cancer; immunotherapy; metastasis; tumor microenvironment
    DOI:  https://doi.org/10.3389/fimmu.2025.1550988
  26. Discov Oncol. 2025 Apr 11. 16(1): 517
       INTRODUCTION: Mitochondria are essential organelles for many aspects of cellular homeostasis. They play an indispensable role in the development and progression of diseases, particularly cancer which is a major cause of death worldwide. We analyzed the scientific research output on mitochondria and cancer via PubMed and Web of Science over the period 1990-2023.
    METHODS: Bibliometric analysis was performed by extracting data linking mitochondria to cancer pathogenesis over the period 1990-2023 from the PubMed database which has a precise and specific search engine. Only articles and reviews were considered. Since PubMed does not support analyses by countries or institutions, we utilized InCites, an analytical tool developed and marketed by Clarivate Analytics. We also used the VOSviewer software developed by the Centre for Science and Technology Studies (Bibliometric Department of Leiden University, Leiden, Netherlands), which enables us to graphically represent links between countries, authors or keywords in cluster form. Finally, we used iCite, a tool developed by the NIH (USA) to access a dashboard of bibliometrics for papers associated with a portfolio. This module can therefore be used to measure whether the research carried out is still basic, translational or clinical.
    RESULTS: In total, 169,555 publications were identified in PubMed relating to 'mitochondria', of which 34,949 (20.61%) concerned 'mitochondria' and 'dysfunction' and 22,406 (13.21%) regarded 'mitochondria' and 'cancer'. Hence, not all mitochondrial dysfunctions may lead to cancer or enhance its progression. Qualitatively, the disciplines of journals were classified into 166 categories among which cancer specialty accounts for only 4.7% of publications. Quantitatively, our analysis showed that cancer/neoplasms in the liver (2569 articles) were placed in the first position. USA occupied the first position among countries contributing the highest number of publications (5695 articles), whereas Egypt came in the thirty-eight position with 84 publications (0.46%). Importantly, USA is the first-ranked country having both the top 1% and 10% impact indicators with 207 and 1459 articles, respectively. By crossing the query 'liver neoplasms' (155,678) with the query 'mitochondria' (169,555), we identified 1336 articles in PubMed over the study period. Among these publications, research areas were classified into 65 categories with the highest percentage of documents included in biochemistry and molecular biology (28.92%), followed by oncology (23.31%).
    CONCLUSIONS: This study underscores the crucial yet underrepresented role of mitochondria in cancer research. Despite their significance in cancer pathogenesis, the proportion of related publications remains relatively low. Our findings highlight the need for further research to deepen our understanding of mitochondrial mechanisms in cancer, which could pave the way for new therapeutic strategies.
    Keywords:  Bibliometrics; Breast; Liver; Lung; Mitochondria; Neoplasm
    DOI:  https://doi.org/10.1007/s12672-025-02139-5
  27. Int Emerg Nurs. 2025 Apr 10. pii: S1755-599X(25)00035-7. [Epub ahead of print]80 101605
       INTRODUCTION: Burnout is a serious issue for caregivers, patients, and healthcare institutions. It is considered a significant problem among nurses, with emergency nurses being particularly affected. This study aims to examine the studies conducted on emergency nursing and burnout using bibliometric analysis and scientific mapping methods.
    METHODS: This study employs bibliometric analysis and scientific mapping methods. The data were obtained through a search conducted in the Web of Science (WoS) database. During the search, the keywords "emergency nursing" and "burnout" were used. A total of 145 studies indexed in the SSCI and SCI-EXPANDED categories were identified. Due to the continuous influx of scientific publications in the database, the search was conducted on a single day, October 23, 2024.
    RESULTS: The research identified a total of 145 studies. The highest number of publications related to emergency nursing and burnout (16 %, n = 23) was recorded in 2022. The journals with the most publications were International Emergency Nursing (32.9 %, n = 46) and Journal of Emergency Nursing (29 %, n = 42). The most frequently used keyword in the studies was "burnout," which was commonly associated with all other keywords. The United States emerged as the country with the highest number of publications on the subject. Additionally, the majority of the studies were published in English (98 %, n = 142). The most-cited publication, with 446 citations, was authored by Adriaenssens, De Gucht, and Maes.
    DISCUSSION: This study aims to comprehensively address the current state of research on emergency nursing and burnout, highlighting its prevalence in the literature. The findings indicate that burnout and its associated challenges among emergency nurses warrant increasing attention. This research emphasizes the importance of developing more effective strategies to combat burnout and underscores the need for ongoing awareness and research to safeguard the well-being of nurses.
    Keywords:  Bibliometric analysis; Burnout; Database; Emergency nursing; Literature
    DOI:  https://doi.org/10.1016/j.ienj.2025.101605
  28. Asian J Psychiatr. 2025 Mar 26. pii: S1876-2018(25)00105-4. [Epub ahead of print]107 104462
       BACKGROUND: BPSD are a heterogeneous neuropsychiatric symptoms that are highly prevalent in persons with dementia (PwD). Understanding research trends on BPSD field is important to appraise and guide future research.
    OBJECTIVES: The purpose of this study was to analyze the 100 most cited articles about BPSD using bibliometrics, and to describe the current trends, patterns, types, area of work done and lacunae.
    MATERIAL AND METHODS: The Google Scholar database was searched using a freely available software, Publish or Perish for retrieving 100 most cited articles on BPSD following PRISMA guidelines. Information related to citations metrics, journals, country of origin, institution of origin, study design and primary area of work was collected.
    RESULTS: The total citation count ranged from 75 to 9096 [mean(SD):343.86(946.24)]. The citation count per year ranged from 3.94 to 303.3. The normalised citation count ranged from 0.09 to 3.57. The maximum number of articles were published in 2005 and 2013 (n = 9 each). John Hopkins University (n = 9) and International Journal of Geriatric Psychiatry (n = 24) contributed to the maximum articles. Nearly 90 % of articles came from high income countries.
    CONCLUSION: Cross-sectional studies and systematic reviews were the most common study methods in the BPSD research. Epidemiological and interventional are the most studied primary areas. Lack of adequate studies with RCT design, qualitative studies and areas including predictors of BPSD, quality of life, cost analysis and staff training was observed. There is markedly lesser research from middle and low-income countries on BPSD.
    Keywords:  BPSD; Citation patterns; Citations; Dementia; Most cited
    DOI:  https://doi.org/10.1016/j.ajp.2025.104462
  29. J Arthroplasty. 2025 Apr 02. pii: S0883-5403(25)00310-9. [Epub ahead of print]
       BACKGROUND: Women account for 2% of arthroplasty surgeons in the United States. It is important to understand how women contribute to the literature in the field of arthroplasty currently. We compared the proportion of first, middle, and senior authorship by women in the top 100 most-cited hip and knee arthroplasty studies published between 2010 and 2024 to the national proportion of women hip and knee arthroplasty surgeons and evaluated the H-indices of authors by sex.
    METHODS: The literature search was performed on the Clarivate Analytics Web of Knowledge database. Once 100 studies met the inclusion criteria, those that did not originate from the US or whose author first names were not included were excluded. The author's sex was determined by first name. The Scopus author database was utilized to determine the H-index for first and senior authors.
    RESULTS: There were 91 papers that met the criteria. These papers were produced by a total of 458 authors, of whom 13.7% were women. There were six (7.4%) of 81 unique first authors, 50 (15.8%) of 315 middle authors, and seven (11.3%) of 62 unique senior authors who were women. Women had lower average H-indices than men.
    CONCLUSION: Women's contributions to the most influential hip and knee arthroplasty articles are much higher than predicted given their underrepresentation in the field, indicating the substantial value they add to leading arthroplasty research. Despite this, disparities exist for women in authorship rank and H-index. These disparities may be mitigated by intentionally fostering greater support for women throughout all phases of orthopaedic surgery training to improve opportunities for impactful research and career advancement.
    Keywords:  arthroplasty; career development; gender diversity; gender equity; orthopaedic surgery; patient outcomes; research
    DOI:  https://doi.org/10.1016/j.arth.2025.03.073
  30. Ir J Med Sci. 2025 Apr 12.
       BACKGROUND: The number of active journals in scholarly publishing has steadily risen. The journal impact factor (JIF) is the most widely used metric for assessing the impact and prestige of a scientific journal. The COVID- 19 pandemic triggered a significant shift in the global academic landscape, particularly in biomedical research.
    AIMS: To systematically investigate the impact of COVID- 19 on the impact factor of top biomedical journals to address the existing knowledge gap on this matter.
    METHODS: Between 2019 and 2023, the impact factor of the top 20 biomedical journals listed in the 2023 Journal Citation Report (JCR) was analysed using a descriptive-analytical approach. Data on JIFs and publications, including COVID- 19-related articles, were collected from Clarivate's Web of Science and PubMed.
    RESULTS: JIFs of the top 20 biomedical journals increased significantly (83.4%) from 2019 to 2021, coinciding with a surge in COVID- 19 publications. This trend stabilised in 2022 but declined by 15.1% in 2023. The number of publications related to COVID- 19 peaked in 2021 (57.3%) and decreased by 12.5% in 2022 and 29.0% in 2023.
    CONCLUSIONS: This study unveils a significant impact of COVID- 19 on the impact factor of top biomedical journals. The increase in JIFs during the pandemic aligns with the surge in COVID- 19 research, but the subsequent decline suggests a potential shift in research focus or knowledge saturation. The study underscores the limitations of JIF as a sole metric for evaluating journal quality and highlights the importance of alternative metrics.
    Keywords:  Bibliometrics; COVID- 19; Journal Impact Factor; Pandemic; Research Impact
    DOI:  https://doi.org/10.1007/s11845-025-03954-z
  31. Photobiomodul Photomed Laser Surg. 2025 Apr 10.
      Objective: The aim of this study was to map and analyze the 20 most cited articles on the use of photobiomodulation (PBM) in different areas of dentistry. Methods: To this end, in June 2024, a search was carried out in the main Web of Science Core Collection for the most cited articles in the following areas: implantology, oral surgery, restorative dentistry, temporomandibular dysfunction and orofacial pain, oral pathology and stomatology, orthodontics, and periodontics. There were no restrictions regarding the year, type of study, and language of publication. From the resulting search, the 20 most cited articles were selected in descending order in each of the cited areas. Information such as authors, number of citations, country of origin of the corresponding author, keywords, study design, year of publication, type of laser used, wavelength, power, and total irradiation time were extracted. Results: The results demonstrated that some characteristics were repeated in the various areas analyzed, such as the fact that Brazil was the country with the largest number of publications; the period between 2012 and 2016 presented the largest number of published articles; the type of laser used in the vast majority of studies was gallium-aluminum arsenide, while the most referenced power and wavelength were 0.25-99 mW and infrared (780-980 nm), respectively. The other bibliometric data varied greatly between areas. Conclusion: Thus, it was observed that PBM is a resource widely used in dentistry and that different protocols are used depending on the specialty, the tissue to be irradiated, and the purpose of the application.
    Keywords:  bibliometrics analysis; dentistry; photobiomodulation; protocol
    DOI:  https://doi.org/10.1089/photob.2025.0004
  32. Endocr Metab Immune Disord Drug Targets. 2025 Apr 04.
       BACKGROUND: As a systemic metabolic disease, type 2 diabetes has gradually become a disease that seriously threatens human health and quality of life worldwide. Many studies have shown that its pathogenesis and treatment are closely related to intestinal cells. However, the research in this field lacks relevant bibliometric analysis. This study aims to review the knowledge structure and research hot spots on intestinal cells and type 2 diabetes and provide a new direction for its future research through bibliometric methods and visual knowledge maps.
    METHODS: Using the Web of Science Core Collection (WoSCC) database, we searched the related literature on intestinal cells and type 2 diabetes from 2004 to 2023, and made bibliometric analysis through VOSviewer, CiteSpace, the "Bibliometrix" R package, and Scimago Graphica. Combined with Bradford's Law, Price's Law, Lotka's Law, and Zipf's law, bibliometrics analysis was conducted on publication time, author, country/region, keywords, journals, and references related to publications in this field.
    RESULTS: A total of 394 articles were included from 51 countries, led by the United States and China. In the past 20 years, the publication of relevant literature has shown a steady growth trend. These articles are from 2486 authors. Among them, Ti-dong Shan and Tao Yu from China have published the most literature, the University of Toronto is the main research institution, the Journal of Biological Chemistry is the journal with the most common citations, and the most prominently cited article is Sugar absorption in the industry: the role of GLUT2.
    CONCLUSION: This study is the first bibliometric analysis that comprehensively summarizes the research trends and hot spots of intestinal cells and type 2 diabetes. This information determines the research hot spots and research frontiers in this field. The hot spots of research are "intestinal epithelial cells", "GLP-1", "SGLT-1", "GLUT2", and "intestinal endocrine cell", while "intestinal epithelial stem cells", "short-chain fatty acid", "bile acid" and "bariatric surgery" may be the focus of future research, which helps clinicians better understand the relationship between intestinal cells and type 2 diabetes, and provides a reference direction for future scholars in this field.
    Keywords:  Intestinal cell; bibliometric; citeSpace; type 2 diabetes mellitus; vOSviewer.
    DOI:  https://doi.org/10.2174/0118715303353611250312043509
  33. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2025 Mar;37(3): 255-261
       OBJECTIVE: To explore the current status, evolution, hot topics, and future research trends in the field of burn-related sepsis research through a visual analysis of literature.
    METHODS: A bibliometric method was employed to retrieve articles related to burn-related sepsis from January 1, 1994, to May 16, 2024, in the China National Knowledge Infrastructure (CNKI) and the Web of Science database. The CiteSpace 6.3.R1 software was used to analyze the retrieved literature. The number of publications, authors, countries, and institutions in both Chinese and English literature was statistically analyzed. Co-occurrence analysis, clustering analysis, and co-citation analysis of keywords were performed.
    RESULTS: A total of 1 090 articles from the CNKI database and 1 143 articles from the Web of Science database were retrieved. Over the past 20 years, the volume of Chinese publications has remained stable, although there has been a slight decline in the past two years. In contrast, the number of English publications, after a period of growth, showed a sharp decline over the past three years. In Chinese literature, 1 457 authors published articles on burn-related sepsis as first authors, with 14 core authors publishing four or more articles. In English literature, 98 authors published articles on burn-related sepsis as first authors. Research on burn-related sepsis was conducted by 76 countries, with the United States having the most collaborations and publications. Globally, 1 349 institutions published articles on burn-related sepsis, with the top institutions being the First Affiliated Hospital of the PLA General Hospital (8 articles) for Chinese literature and the University of Texas Medical Branch (57 articles) for English literature. In the co-occurrence analysis, 208 Chinese keywords and 211 English keywords were included. Excluding keywords related to search terms, the top five most frequent keywords in Chinese literature were burn, sepsis, infection, severe burn, and procalcitonin; the top five most frequent keywords in English literature were sepsis, septic shock, mortality, injury, and burn injury. Chinese keyword analysis identified six clusters, with the largest being sepsis, followed by procalcitonin, infection, and severe burn. English keyword analysis identified seven clusters, with the largest being expression, followed by epidemiology, inhalation injury, and acute kidney injury. The persistent clusters in Chinese literature were procalcitonin, with recent emerging nodes being severe burn, inflammatory response, platelets, and predictive value. In English literature, the persistent clusters were inhalation injury and nitric oxide, with recent emerging nodes being continuous renal replacement therapy, hemorrhagic shock, and early enteral nutrition. The longest-lasting emergent keyword in Chinese literature was delayed resuscitation (2003-2010), with the highest emergent strength being severe burn. In English literature, the longest-lasting emergent keywords, each lasting five years, were nitric oxide (2007-2012), management (2019-2024), and impact (2019-2024), with the highest emergent strength being thermal injury.
    CONCLUSIONS: Research on burn-related sepsis has shifted from focusing on early studies on pathogenesis and mortality to focus on prevention, treatment, and early diagnosis. Future research is expected to focus on early diagnosis and risk factors of burn-related sepsis.
    DOI:  https://doi.org/10.3760/cma.j.cn121430-20240806-00669
  34. F1000Res. 2025 ;14 17
       Background: Honey, a natural product with diverse bioactive compounds, has been increasingly explored for its potential anticancer properties. This study aims to comprehensively analyze the scientific literature on the relationship between honey and breast cancer.
    Methods: A bibliometric analysis was conducted using the ScienceDirect database to identify publications from 2014 to 2024. Data on publication trends, author collaboration, and keyword analysis were extracted to gain insight into the research landscape. Keyword analysis identified nine distinct clusters, indicating diverse research directions regarding the role of honey in breast cancer treatment.
    Results: In Key journals such as the Journal of Ethnopharmacology and Food Chemistry have been at the forefront of disseminating research findings in this domain, demonstrating a strongly interdisciplinary approach that bridges traditional medicine and modern scientific inquiry. The increasing interest in the anticancer properties of honey, as evidenced by the growing number of studies, underlines its potential as a promising natural agent for breast cancer prevention and treatment.
    Conclusions: This study provides a comprehensive overview of the current knowledge landscape and highlights emerging issues that require further exploration.
    Keywords:  ScienceDirect; VOSviewer; bibliometric analysis; breast cancer; honey
    DOI:  https://doi.org/10.12688/f1000research.159595.3
  35. Med Oral Patol Oral Cir Bucal. 2025 Apr 07. pii: 27169. [Epub ahead of print]
       BACKGROUND: Research in Oral Medicine (OM) and Oral Pathology (OP) in Brazil has experienced remarkable growth, gaining international recognition. However, no analysis has evaluated the patterns of evolution of international partnerships and their role in advancing Brazilian research in these areas. This study analyzed collaborations between Brazilian and international researchers in OP/OM.
    MATERIAL AND METHODS: A bibliometric cross-sectional survey was conducted using data from Brazilian researchers in OP/OM, identified through the Brazilian Society of Stomatology and Maxillofacial Pathology. Researchers' curriculum on the Lattes platform were analyzed, and data on publications, citations, co-authorships, affiliations, and journals were collected from the Scopus database, focusing on international collaborations. Bibliometric analyses were performed using the Bibliometrix tool in R Studio and VOSviewer software. Statistical trends between decades were compared using the Kruskal-Wallis test.
    RESULTS: The sample included 229 researchers, most females (61.6%), affiliated with public institutions (78.9%), and with a mean time since achieving the PhD of 15.27 years. Almost half of the researchers (43.2%) had postdoctoral training, and among them 43.4% completed it abroad, mainly in the United States (USA), Canada, and the United Kingdom (UK). A total of 2,027 articles were analyzed, revealing a 10.53% annual growth in publications. The number of international collaborations significantly increased over decades (p < 0.001), with USA, UK, India, and Italy being the leading partners. Collaborative publications showed a significant rise in citations (42.61 per paper), mainly in high-impact journals.
    CONCLUSIONS: A steady increase in international collaborations in OP/OM was identified, especially with the USA and the UK. These partnerships have increased citations and publications in high-impact journals, which highlights their benefit and importance for research in these areas.
    DOI:  https://doi.org/10.4317/medoral.27169
  36. Open Vet J. 2025 Feb;15(2): 1009-1023
       Background: Camel pathology research has evolved significantly over the past five decades, reflecting the growing recognition of camels' importance in agriculture, zoonotic disease control, and economic contributions. However, there has been limited evaluation of research trends, thematic advancements, and international collaborations in this field. Aim: This study aimed to conduct a bibliometric analysis of camel pathology research published between 1971 and 2024. The study identified key research themes, assessed collaboration patterns, and highlighted gaps to guide future research efforts in camel pathology.
    Results: The analysis included 297 research articles retrieved from Scopus. A steady increase in publications was observed, with a notable surge after 2010 due to advancements in molecular techniques and rising global interest in camel health. Thematic analysis identified well-established motor themes, such as camel histopathology and tuberculosis, while basic themes, such as infertility and postmortem studies, were found to be underexplored. Collaboration analysis revealed the dominance of Saudi Arabia and Egypt, emphasizing their pivotal role in camel research. However, under- represented regions, such as Sub-Saharan Africa, showed limited participation in collaborative networks.
    Conclusion: This study highlights the transition from traditional pathological techniques to advanced molecular and epidemiological approaches, enabling better disease detection, diagnosis, and management in camels. Despite significant progress, the slower adoption of cutting-edge technologies in certain regions indicates the need for targeted capacity-building initiatives. By addressing these gaps and fostering international collaborations, camel pathology research can contribute to sustainable development, improved public health, and improved global food security.
    Keywords:  Bibliometric; Camel; Histopathology; Pathology; Trend
    DOI:  https://doi.org/10.5455/OVJ.2025.v15.i2.49
  37. J Clin Transl Sci. 2025 ;9(1): e64
       Introduction: Translational science and implementation science are two disciplines that integrate scientific findings into practice within healthcare. One method to assess the integration of these fields is to review the academic crossover between the disciplines with respect to shared citations in the peer-reviewed literature.
    Methods: This paper used direct citation network analysis to identify potential conceptual gaps and connections between the literature in implementation science and translational science. Bibliographic references were downloaded from Web of Science to create directed citation network maps in VosViewer. Heat maps visualized the top cited literature in each field.
    Results: A literature search yielded 6,111 publications in translational science and 7,003 publications in implementation science. When all publications were combined in a directed citation network map, two separate groups of publications emerged, representing the two fields of implementation science and translational science. When the top 50 cited translational science publications were combined with implementation science publications, 14% had a 100%+ increase in citation links, 44% had a mean increase of 2.4%, and 42% shared no links. When the top 50 cited implementation science publications were combined with translational science publications, 2% had a 100%+ increase in citation links, 92% had a 3.3% mean increase, and 6% had no shared links.
    Conclusions: Results suggest moderate academic overlap in the way published authors cite each other between translational science and implementation science. We hope the implications of this paper may promote continued collaborations between these fields to disseminate lessons learned and bridge research into practice more efficiently.
    Keywords:  CTSA; Implementation science; VosViewer; bibliometrics; citation network analysis; translational science
    DOI:  https://doi.org/10.1017/cts.2025.11
  38. J Robot Surg. 2025 Apr 11. 19(1): 146
      With the increasing integration of robotic technology into medical practice, robotic-assisted arthroplasty (RAA) has emerged as a significant research focus. This study employs CiteSpace, a bibliometric analysis tool, to systematically examine the current state and future directions of RAA research on a global scale. By retrieving relevant literature from the Web of Science Core Collection database spanning from 1997 to 2024, a total of 229 articles were identified for analysis. The findings indicate a steady rise in the number of publications within this field. China, the United States, and South Korea are the leading contributors, with the Chinese People's Liberation Army General Hospital being the most prolific institution. Keyword clustering analysis reveals that key research areas include total hip arthroplasty, Markov decision analysis, total knee arthroplasty, robotic-assisted total knee arthroplasty, diverse assistive techniques, patient-reported outcome differences, robot-assisted total hip arthroplasty, and learning curves. Emerging trends are primarily centered around system development, navigation technologies, manual implantation methods, functional outcomes, and ossification processes.
    Keywords:  Arthroplasty; Bibliometrics; CiteSpace; Robotic-assisted; Visual analysis
    DOI:  https://doi.org/10.1007/s11701-025-02331-3
  39. AIDS Res Ther. 2025 Apr 10. 22(1): 47
       BACKGROUND: The rapid initiation of antiretroviral therapy has become an international trend, necessitating lifelong medication for all HIV patients. Sanger sequencing, as the gold standard for clinically detecting HIV drug resistance, often fails to detect mutations comprising less than 20% of the total viral population. With the advancement of detection technologies, HIV-1 drug-resistant minority variants have garnered increasing attention. Few studies have analyzed the hotspots and trends in this field, which bibliometrics can effectively address.
    METHODS: Publications related to HIV-1 DRMinVs from 1999 to 2024 were searched on the Web of Science Core Collection database. Visual knowledge maps and bibliometric analyses were generated using VOSviewer and Bibliometrix.
    RESULTS: In total, 289 publications concerning HIV-1 drug-resistant minority variants were identified from 1999 to 2024, demonstrating a steady increase in publication output over the years. Although developed countries, led by the United States, are the main contributors, 9.57% and 2.48% of the research from the top five publishing countries focus on populations in Africa and other developing countries, respectively. Most contributing institutions are universities and public health organizations, with the University of Washington having the highest publication output. The Journal of Antimicrobial Chemotherapy holds the highest prominence among journals in this domain. The main hotspots include "drug classes," "drug resistance surveillance," "mother-to-child transmission," "treatment outcomes," and "targets of HIV-1 drug resistance testing," And we found several noteworthy shifts in research trends in HIV-1 drug-resistant minority variants studies, including changes in drug resistance testing technologies, the primary study population, and drug classes.
    CONCLUSIONS: This is the first bibliometric analysis of publications related to HIV-1 DRMinVs from 1999 to 2024. We analyzed the key research contributions across countries, institutions and journals. Based on keyword co-occurrence and cluster analysis, we identified several noteworthy shifts in research trends in HIV-1 DRMinVs studies, including changes in drug resistance testing technologies, the primary study population, and drug classes.
    Keywords:  Bibliometrics; Drug-resistant minority variants; HIV-1; Hotspots
    DOI:  https://doi.org/10.1186/s12981-025-00739-3
  40. Endocr Metab Immune Disord Drug Targets. 2025 Apr 07.
       BACKGROUND: Diabetes mellitus is a chronic disease that seriously endangers human health, and mesenchymal stem cell [MSC] therapy is an emerging medical approach. Therefore, analyzing the effectiveness of MSCs in the literature is highly important for building relevant knowledge networks and promoting development in this field.
    METHODS: The Web of Science database was selected as the source of literature, and all the literature on MSCs in diabetes from January 1, 2000, to October 18, 2023, was selected. After screening, CiteSpace and VOSviewer were imported into bibliometric software to construct the knowledge visualization map. Journal analysis, author analysis, country/region analysis, reference analysis, and keyword analysis were performed.
    RESULTS: A total of 2912 articles and reviews were included. The number of articles on the use of MSCs for the treatment of diabetes is increasing annually. These publications originate mainly from 90 countries and 278 institutions, of which China and the United States were the top producers. We identified 15384 authors, with Liu Jiejie having the largest number of articles and Shapiro Amj being the most frequently co-cited. Stem Cell Res Ther was the most studied journal, and Diabetes was the most frequently cited journal. After analysis, the most common keywords were MSCs, diabetes mellitus, expression, transplantation, and differentiation.
    CONCLUSIONS: Research into MSC-based interventions for diabetes is booming. In the future, cooperation and connections between various countries and institutions should be strengthened. MSCinduced differentiation into insulin-producing cells, MSCs homing in vivo, the therapeutic effect of MSCs on diabetic nephropathy, and the therapeutic effect of exosomes secreted by MSCs constitute the current research hotspots and development trends for future research.
    Keywords:  MSCs; bibliometrics; citeSpace; diabetes; vOSviewer.
    DOI:  https://doi.org/10.2174/0118715303348724250310082224
  41. Ann Med Surg (Lond). 2025 Apr;87(4): 2187-2203
       Background: The integration of artificial intelligence (AI) into cardiovascular procedures has significantly advanced diagnostic accuracy, outcome prediction, and robotic-assisted surgeries. However, a comprehensive bibliometric analysis of AI's impact in this field is lacking. This study examines research trends, key contributors, and emerging themes in AI-driven cardiovascular interventions.
    Methods: We retrieved relevant publications from the Web of Science Core Collection and analyzed them using VOSviewer, CiteSpace, and Biblioshiny to map research trends and collaborations.
    Results: AI-related cardiovascular research has grown substantially from 1993 to 2024, with a sharp increase from 2020 to 2023, peaking at 93 publications in 2023. The USA (127 papers), China (79), and England (31) were the top contributors, with Harvard University leading institutional output (17 papers). Frontiers in Cardiovascular Medicine was the most prolific journal. Core research themes included "machine learning," "mortality," and "cardiac surgery," with emerging trends in "association," "implantation," and "aortic stenosis," underscoring AI's expanding role in predictive modeling and surgical outcomes.
    Conclusion: AI demonstrates transformative potential in cardiovascular procedures, particularly in diagnostic imaging, predictive modeling, and patient management. This bibliometric analysis highlights the growing interest in AI applications and provides a framework for integrating AI into clinical workflows to enhance diagnostic accuracy, treatment strategies, and patient outcomes.
    Keywords:  artificial intelligence; cardiovascular surgery; machine learning
    DOI:  https://doi.org/10.1097/MS9.0000000000003112
  42. Hum Vaccin Immunother. 2025 Dec;21(1): 2488074
      Apoptosis is vital for improving the efficacy of lung cancer (LC) immunotherapy by targeting cancer cell elimination. Despite its importance, there is a lack of comprehensive bibliometric studies analyzing global research on apoptosis in LC immunotherapy. This analysis aims to address this gap by highlighting key trends, contributors, and future directions. A total of 969 publications from 1996 to 2024 were extracted from the Web of Science Core Collection. Analysis was conducted using VOSviewer, CiteSpace, and the R package 'bibliometrix.' The study included contributions from 6,894 researchers across 1,469 institutions in 61 countries, with research published in 356 journals. The volume of publications has steadily increased, led by China and the United States, with Sichuan University as the top contributor. The journal Cancers published the most articles, while Cancer Research had the highest co-citations. Yu-Quan Wei was the leading author, and Jemal, A. was the most frequently co-cited. Key research themes include "cell death mechanisms," "immune regulation," "combination therapies," "gene and nanomedicine applications," and "traditional Chinese medicine (TCM)." Future research is likely to focus on "coordinated regulation of multiple cell death pathways," "modulation of the tumor immune microenvironment," "optimization of combination therapies," "novel strategies in gene regulation," and the "integration of TCM" for personalized treatment. This is the first bibliometric analysis on the role of apoptosis in LC immunotherapy, providing an landscape of global research patterns and emerging therapeutic strategies. The findings offer insights to guide future research and optimize treatment approaches.
    Keywords:  Lung cancer; apoptosis; bibliometric analysis; immunotherapy; research trends
    DOI:  https://doi.org/10.1080/21645515.2025.2488074
  43. Ann Med Surg (Lond). 2025 Mar;87(3): 1487-1505
       Objective: This study aims to conduct a bibliometric analysis of the triglyceride-glucose (TyG) index in relation to cardiovascular disorders.
    Methods: Data for the analysis were extracted from the Web of Science Core Collection database on 13 July 2024. We utilized VOSviewer, CiteSpace, and Biblioshiny tools for the analysis.
    Results: The study revealed a marked increase in research outputs on the TyG index in recent years, peaking with 137 publications in 2023. China emerged as the leading contributor, followed by the USA. The Chinese Academy of Medical Sciences and Peking Union Medical College were among the top contributing institutions. Shouling Wu and Shuohua Chen emerged as the leading authors, with the journal Cardiovascular Diabetology publishing the most articles on this topic. Keyword analysis identified "insulin-resistance" as the most frequently occurring term, followed by "risk." Cluster analysis identified eleven key research areas, including "percutaneous coronary intervention," "obesity indicators," "arterial stiffness," and "heart failure."
    Conclusion: This bibliometric analysis highlights the expanding role of the TyG index in metabolic and cardiovascular research. Key clusters such as percutaneous coronary intervention, obesity indicators, arterial stiffness, heart failure, new-onset hypertension, predicting outcomes, and subclinical coronary artery disease emphasize its wide applicability across diverse clinical settings. The keyword "risk" was the most frequently occurring term, underscoring the importance of the TyG index in cardiovascular risk assessment, alongside its growing use in prognostic applications. These findings reflect the increasing recognition of the TyG index as a pivotal biomarker in cardiovascular medicine and encourage further exploration of its clinical integration.
    Keywords:  bibliometric analysis; cardiovascular diseases; data visualization; triglyceride-glucose index
    DOI:  https://doi.org/10.1097/MS9.0000000000003019
  44. Ann Med Surg (Lond). 2025 Apr;87(4): 2133-2148
       Background: Dipeptidyl peptidase-4 (DPP-4) inhibitors are oral antihyperglycemic agents commonly prescribed for type 2 diabetes (T2DM). Due to the intricate relationship between glucose regulation and cardiovascular diseases (CVDs), DPP-4 inhibitors have attracted attention for their cardiovascular safety and efficacy. This bibliometric analysis aims to provide insights into the global research landscape on DPP-4 inhibitors and cardiovascular outcomes (CVOs).
    Methods: A bibliometric analysis was performed, using the Web of Science Core Collection. Data were analyzed using VOSviewer, CiteSpace, and Biblioshiny.
    Results: The United States led in publication output, followed by Japan and China. Harvard University and the University of Toronto were the leading institutions. The most influential journals were Cardiovascular Diabetology and Diabetes Obesity & Metabolism. Darren K. McGuire was the most prolific author followed by Rury R. Holman. The most commonly occurring keyword was heart failure. Cluster analysis revealed key thematic areas in the field, including "incretin-based therapy," "dipeptidyl peptidase-4 inhibition," and "cardiovascular safety." Emerging clusters, such as "atrial fibrillation," have gained attention in recent years, highlighting evolving areas of investigation.
    Conclusion: This study underscores the importance of CVOs in the research on DPP-4 inhibitors. The high frequency of keywords such as "heart failure," along with recent terms like "mortality" and "risk," highlights a strong focus on cardiovascular safety and complications in the literature. Our analysis reflected that most studies address these critical aspects of cardiovascular health, discussing the potential role of DPP-4 inhibitors in mitigating adverse outcomes, particularly in patients with T2DM.
    Keywords:  DPP-4 inhibitors; bibliometric analysis; cardiovascular outcomes; research trends; type 2 diabetes
    DOI:  https://doi.org/10.1097/MS9.0000000000003089
  45. Int J Biometeorol. 2025 Apr 11.
      Agricultural research has consistently progressed through the integration of advanced technologies into farming systems. A significant paradigm shift in agricultural production system research has occurred with the development of simulation models, most notably the Agricultural Production System Simulator (APSIM). The APSIM supports a wide range of applications in agriculture, including on-farm decision-making on the basis of historical climatic data and future climatic projections. It also informs policymaking through climate risk assessment, forecast-based management systems, and simulations for diverse crops and cropping systems. These applications offer opportunities for bibliometric analysis, a quantitative method for analyzing trends in academic research and publications to explore the impact, trends, and research gaps in this research domain. We conducted a bibliometric analysis of APSIM-related research publications indexed in the Scopus database. The analysis reveals an exponential growth of APSIM-related research from 1989 to 2023, with 1273 documents published across 118 scholarly journals, indicating the model's increasing relevance in addressing the critical challenges of global agricultural research. Our analyses identify the contributions and collaborative networks among authors, journals, institutions, and countries. It identifies key emerging issues, including climate change adaptation and mitigation, precision agriculture, and advancements in crop modeling, indicating the adaptability of APSIM to modern agricultural challenges. These findings will serve as valuable resources for researchers to facilitate collaboration, innovation, and informed decision-making in addressing the complex demands of 21st century agriculture.
    Keywords:  APSIM; Bibliometrics; Machine learning; System simulation modeling
    DOI:  https://doi.org/10.1007/s00484-025-02914-7
  46. Mol Neurobiol. 2025 Apr 11.
      This study employs a bibliometric analysis to examine the evolution and future trajectories in epigenetic modifications in neurology from 2004 to 2024. A total of 12,964 publications were scrutinized via the R bibliometrix package and VOSviewer for network visualization, complemented by Scimagp Graphica to elucidate global collaborative networks. Our extensive review reveals a significant growth in the field of epigenetic neurology studies, driven by an increased output of publications and evidenced by an enhanced focus on epigenetic modifications. The USA and McGill University are recognized as central contributors, with Nature leading as the most prolific journal and J. Mill and E.J. Nestler distinguishing themselves as key authors by publication volume and citation impact, respectively. A detailed keyword analysis highlighted "expression," "DNA methylation," "brain," "gene-expression," and "gene" as the most recurrent terms, indicating core areas of research concentration. Subsequent manual analysis due to software-detected inaccuracies reaffirmed Alzheimer's disease, cancer, and schizophrenia as predominant neurological diseases associated with epigenetic studies. Pathophysiological processes such as DNA methylation, oxidative stress, and synaptic plasticity have been extensively examined in relation to epigenetic modifications in neurology. Synthesis of the reference literature analysis identifies critical themes such as the role of glucocorticoid receptors, the significance of hydroxymethylcytosine in neural DNA, the implications of epigenetic patterns in mental health, and the impact of BDNF gene on memory consolidation. Emerging technologies and underexplored areas further highlight future directions. These insights into epigenetic research in neurology indicate a sustained and intensifying trajectory, hinting at expanding horizons for future therapeutic approaches and interventions. Our findings underscore an active and progressing interest in neurological epigenetics, suggesting a continued expansion and specialization in the exploration of epigenetic mechanisms and their clinical relevance.
    Keywords:  Bibliometrics; Emerging trends; Epigenetic modifications; Hotspots; Neurology
    DOI:  https://doi.org/10.1007/s12035-025-04862-0
  47. JCO Oncol Pract. 2025 Apr 10. OP2400767
       PURPOSE: Altmetric Attention Score (AAS) is a measure of the quantity of attention that a scholarly work receives, and evidence about gender gaps in AAS in oncology is lacking. Our objective was to analyze potential disparities in the AAS within oncology by comparing research publications authored by women first and last authors with those authored by men. Secondarily, we aimed to quantify the extent of over-/undercitation by gender.
    MATERIALS AND METHODS: The initial data set was compiled from the Altmetric database through Application Programming Interface (API) using oncology-related search terms. Author gender categories were assigned on the basis of the Gender Guesser API. For example, those with first and last authors labeled woman were categorized as woman first author/woman last author (WW). Over-/undercitation was calculated using observed citations and expected citations. Analyses were completed both for the oncology literature as a whole and for prominent subspecialty peer-reviewed journals.
    RESULTS: Our search yielded 652,834 articles published between January 1, 2009, and January 31, 2024. For AAS, women in the first author position had a 15.2% lower score compared with men counterparts and women in the last author position had an 8.3% lower score than men (P < .01 for both). Although the proportion of WW authors in oncology publications increased over time, the man first author/man last author combination was overcited (mean citation percentage difference [MCD] = +16.2%), whereas WW was undercited (MCD = -7.7%). There was variation in both proportion of WW papers and over-/undercitation among oncologic subspecialties.
    CONCLUSION: Significant gender disparities in citation rates and AAS exist across various fields within oncology. This highlights a systemic issue where woman-authored research is undercited and receives less attention compared with man-authored work, with the potential to affect career advancement, funding opportunities, and academic recognition.
    DOI:  https://doi.org/10.1200/OP-24-00767
  48. J Adv Nurs. 2025 Apr 07.
       AIM: The aim of this study is to map nursing publications on the United Nations Sustainable Development Goals (SDG) in Web of Science, highlighting trends, key contributors, and central research themes to identify potential areas for future research.
    BACKGROUND: The globally-spanning 2030 Agenda promotes sustainable development using research technology and scientific innovation. However, research data availability is a challenge. By conducting big data analyses, using all available nursing research literature indexed in the Web of Science database (Core Collection) pertaining to this field, aid in understanding and advancing this area.
    METHODS: This study adopts a cross-sectional descriptive bibliometric study design.
    RESULTS: The search yielded 131 publications, comprising 116 articles (89%) and 15 review articles (11%). This can be compared to adjacent disciplines such as Internal General Medicine (n = 360), Nutrition/Dietetics (n = 171), and Paediatrics (n = 152). The leading countries in publication output were the United States, Australia, and the United Kingdom. Among the included publications, only eight SDGs were addressed: SDG3 (Good Health and Well-Being), SDG13 (Climate Action), SDG4 (Quality Education), SDG5 (Gender Equality), SDG6 (Clean Water and Sanitation), SDG16 (Peace, Justice, and Strong Institutions), SDG1 (No Poverty), and SDG9 (Industry, Innovation, and Infrastructure).
    CONCLUSIONS: The findings indicate a scarcity of articles in nursing publications focusing on the SDGs, suggesting insufficient evidence of nursing's contributions to these goals-particularly beyond SDG3.
    IMPLICATIONS: This study provides a comprehensive bibliometric review and analysis of existing nursing publications on the SDGs. The results offer valuable insights for future research areas related to the SDGs, particularly for nursing scholars, clinicians, managers, and policymakers concerned with the underrepresentation of nursing publications. To address this gap and advance both the SDGs and quality patient care, action plans should be developed to integrate the SDGs into daily nursing practice. No Patient or Public Contribution. This study was a bibliometric analysis.
    Keywords:  evidence gaps; gender equity; global health; nursing research; patient care; sustainability; sustainable development
    DOI:  https://doi.org/10.1111/jan.16953
  49. Brain Behav. 2025 Apr;15(4): e70486
       BACKGROUND: Since its discovery in the late 20th century, research on mirror neurons has become a pivotal area in neuroscience, linked to various cognitive and social functions. This bibliometric analysis explores the research trajectory, key research topics, and future trends in the field of mirror neuron research.
    METHODS: We searched the Web of Science Core Collection (WoSCC) database for publications from 1996 to 2024 on mirror neuron research. Statistical and visualization analyses were performed using CiteSpace and VOSviewer.
    RESULTS: Publication output on mirror neurons peaked in 2013 and remained active. High-impact journals such as Science, Brain, Neuron, PNAS, and NeuroImage frequently feature findings on the mirror neuron system, including its distribution, neural coding, and roles in intention understanding, affective empathy, motor learning, autism, and neurological disorders. Keyword clustering reveals major directions in cognitive neuroscience, motor neuroscience, and neurostimulation, whereas burst detection underscores the emerging significance of brain-computer interfaces (BCIs). Research methodologies have been evolving from traditional electrophysiological recordings to advanced techniques such as functional magnetic resonance imaging, transcranial magnetic stimulation, and BCIs, highlighting a dynamic, multidisciplinary progression.
    CONCLUSIONS: This study identifies key areas associated with mirror neurons and anticipates that future work will integrate findings with artificial intelligence, clinical interventions, and novel neuroimaging techniques, providing new perspectives on complex socio-cognitive issues and their applications in both basic science and clinical practice.
    Keywords:  bibliometrics; interdisciplinary research; mirror mechanism; mirror neurons; neuroscience
    DOI:  https://doi.org/10.1002/brb3.70486
  50. J Cancer Surviv. 2025 Apr 05.
       PURPOSE: Meditation is well known for its positive effects on recovery and quality of life enhancement among cancer patients. Meditation as an adjuvant therapy has received extensive attention from international scholars in relieving pain, reducing psychological pressure and improving the quality of life of cancer patients. In this study, we examine the current status of meditation in cancer research and its potential application value and future development.
    METHODS: We collected 825 articles published in the Web of science Core Collection between January 1, 1976, and July 1, 2024, covering 11 cancer types. Bibliometric tools such as VOSviewer, Citespace, and Biblioshiny were used to analyze publication trends, international collaborations, author contributions, keywords, co-citations, and journal impact.
    RESULTS: First, the steadily rising number of publications indicates an increasing scholarly focus on meditation's benefits for patients. Second, the USA, Australia, and China are the countries with the highest number of publications in each of the three clusters. Additionally, Carlson Linda E and eight other scholars are influential scholars in this field. Finally, through keyword co-occurrence and co-citation analysis, we identified "breast cancer," "quality of life," and "psychological intervention" as the hot topics of current research.
    CONCLUSIONS: The study provides a valuable reference for scientific researchers to further explore meditation in cancer treatment.
    IMPLICATIONS FOR CANCER SURVIVORS: This study highlights the growing interest in meditation as an adjuvant therapy for cancer patients, underscoring its potential to improve survivors' quality of life. Current research primarily focuses on quality of life, mindfulness-based stress reduction therapy, and clinical trials. Additionally, online, virtual reality technology, cancer survivors, fear of cancer recurrence, and qualitative research may become cutting-edge research directions in the future.
    Keywords:  Bibliometric analysis; Cancer patients; Data visualization; Mediation; Research frontiers
    DOI:  https://doi.org/10.1007/s11764-025-01784-7
  51. Disaster Med Public Health Prep. 2025 Apr 11. 19 e88
       OBJECTIVE: The outbreak of major epidemics, such as COVID-19, has had a significant impact on supply chains. This study aimed to explore knowledge innovation in the field of emergency supply chain during pandemics with a systematic quantitative analysis.
    METHODS: Based on the Web of Science (WOS) Core Collection, proposing a 3-stage systematic analysis framework, and utilizing bibliometrics, Dynamic Topic Models (DTM), and regression analysis to comprehensively examine supply chain innovations triggered by pandemics.
    RESULTS: A total of 888 literature were obtained from the WOS database. There was a surge in the number of publications in recent years, indicating a new field of research on Pandemic Triggered Emergency Supply Chain (PTESC) is gradually forming. Through a 3-stage analysis, this study identifies the literature knowledge base and distribution of research hotspots in this field and predicts future research hotspots and trends mainly boil down to 3 aspects: pandemic-triggered emergency supply chain innovations in key industries, management, and technologies.
    CONCLUSIONS: COVID-19 strengthened academic exchange and cooperation and promoted knowledge output in this field. This study provides an in-depth perspective on emergency supply chain research and helps researchers understand the overall landscape of the field, identifying future research directions.
    Keywords:  DTM; bibliometrics; emergency supply chain; pandemic
    DOI:  https://doi.org/10.1017/dmp.2025.88
  52. Ann Med Surg (Lond). 2025 Apr;87(4): 1947-1968
       Background: The application of artificial intelligence (AI) in cardiac imaging has rapidly evolved, offering enhanced accuracy and efficiency in the diagnosis and management of cardiovascular diseases. This bibliometric study aimed to evaluate research trends, impact, and scholarly output in this expanding field.
    Methods: A systematic search was conducted on 14 August 2024 using the Web of Science Core Collection database. VOSviewer, CiteSpace, and Biblioshiny were utilized for data analysis.
    Results: The findings revealed a significant increase in publications on AI in cardiovascular imaging, particularly from 2018 to 2023, with the United States leading in research output. England and the United States have emerged as central hubs in the global research network, highlighting their role in generating high-quality and impactful publications. The University of London was identified as the top contributing institution, while Frontiers in Cardiovascular Medicine was the most prolific journal. Keyword analysis highlighted machine learning, echocardiography, and diagnosis as the most frequently occurring terms. A time trend analysis showed a shift in research focus toward AI applications in cardiac computed tomography (CT) and magnetic resonance imaging (MRI), with recent keywords like ejection fraction, risk, and heart failure reflecting emerging areas of interest.
    Conclusion: Healthcare providers should consider integrating AI tools into cardiovascular imaging practice, as AI has demonstrated the potential to enhance diagnostic accuracy and improve patient outcomes. This study highlights the rising importance of AI in personalized and predictive cardiovascular care, urging healthcare providers to stay informed about these advancements to enhance clinical decision-making and patient management.
    Keywords:  artificial intelligence; bibliometric analysis; cardiac imaging; cardiovascular diseases; deep learning; machine learning
    DOI:  https://doi.org/10.1097/MS9.0000000000003080
  53. Front Aging Neurosci. 2025 ;17 1563142
       Background: Parkinson's disease (PD) is characterized pathologically by the degeneration of dopaminergic neurons and the formation of Lewy bodies. Among the various cellular and molecular mechanisms of PD, astrocyte dysfunction is one of the causes of disease development. This study aims to explore the research hotspots, frontiers, and prospective directions regarding PD and astrocytes.
    Method: Relevant academic publications were searched through the Web of Science database. CiteSpace, VOSviewer, and bibliometrix were used for visualization and quantitative evaluation.
    Results: A total of 2,408 publications related to the study topic were included in the analysis. From 2001 to 2024, annual publications gradually increased. Activated countries were concentrated in North America, Asia, and Europe. The United States and China were the main research leaders. Nanjing Medical University was the active institution with the largest number of publications, and the University of Cambridge had the highest influence on publications. International Journal of Molecular Sciences was the core journal with the most publications. Dr. Hu, Gang was the most productive author, and Dr. Saarma, Mart was the most influential author. Research hotspots included astrocytes, PD, neuroinflammation, alpha-synuclein (α-Syn), microglia, oxidative stress, and neurodegeneration. In recent years, NLRP3 inflammasome, extracellular vesicles (EVs), and signaling pathway were the research topics with strong burst power.
    Conclusion: Collaboration among different countries, organizations, and authors has effectively promoted the rapid development of this field, and the research achievements have gradually increased. The research hotspots mainly focused on neuroinflammation, α-Syn, microglia, oxidative stress, and neurodegeneration. NLRP3 inflammasome, EVs, and signaling pathway are research directions in the future.
    Keywords:  Parkinson’s disease; alpha-synuclein; astrocytes; neuroinflammation; oxidative stress
    DOI:  https://doi.org/10.3389/fnagi.2025.1563142
  54. Postgrad Med J. 2025 Apr 11. pii: qgaf053. [Epub ahead of print]
      
    Keywords:  citation cartel; citation manipulation; citation racism; coercive citation; padded citation
    DOI:  https://doi.org/10.1093/postmj/qgaf053
  55. J Surg Educ. 2025 Apr 08. pii: S1931-7204(25)00089-3. [Epub ahead of print]82(6): 103509
       OBJECTIVE: The gender disparity in orthopedic surgery is multifactorial, driven by the lack of female mentorship, limited female leadership in academic roles, and challenges in pursuing academic positions. Research productivity and authorship are areas where these disparities manifest, with women being significantly underrepresented. The primary objective of this study is to evaluate whether gender disparities in orthopedic research productivity are apparent as early as medical school.
    DESIGN, SETTING, AND PARTICIPANTS: A comprehensive analysis was conducted on orthopedic surgery residents from 208 ACGME-accredited programs across the United States. Data were collected between February and April 2024 from publicly accessible resources, covering 4320 residents (927 females, 3393 males). Pre-residency and residency publication data were gathered using Elsevier Scopus Application Programming Interface (APIs). The study compared total publications and first author publications between male and female residents, categorizing them as preresidency or residency publications. p-values were calculated using unpaired t-tests to evaluate gender differences.
    RESULTS: Among the 2723 residents with preresidency publications, there was no statistically significant difference between male and female residents in the mean number of publications (p = 0.1267) or first authorship publications (p = 0.9389). During residency, however, male residents had a significantly higher mean number of publications than female residents (p = 0.0002), although no significant difference was observed in first authorships (p = 0.2538).
    CONCLUSION: Our results suggest that while gender disparities in research productivity are not apparent preresidency, they emerge during residency, with male residents producing more publications. This difference is likely influenced by the lack of mentorship and female representation within the field of orthopedic surgery. Addressing these disparities requires targeted efforts to increase female mentorship and support within orthopedic residency programs.
    Keywords:  Gender disparities in orthopedics; medical school research; orthopedic surgery residents; research in orthopedic residency; research productivity
    DOI:  https://doi.org/10.1016/j.jsurg.2025.103509
  56. Ren Fail. 2025 Dec;47(1): 2487212
       BACKGROUND: Endothelin A receptor antagonists (ERAs) have emerged as pivotal therapeutic agents in managing pulmonary hypertension (PH) and various kidney disorders, including chronic kidney disease (CKD) and proteinuric glomerular diseases such as IgA nephropathy (IgAN) and focal segmental glomerulosclerosis (FSGS). Although initially developed for pulmonary applications, recent research has highlighted their renoprotective effects, expanding their role in nephrology. This study presents a comprehensive bibliometric analysis of global research trends, key contributors, and emerging applications of ERAs in kidney care over the past three decades.
    METHODS: A bibliometric analysis was performed using the Science Citation Index Expanded database (1992-2023). Relevant kidney-related publications were identified through specific keyword searches. Author performance was assessed using the Y-index.
    RESULTS: ERA-related research has shown significant growth, particularly in nephrology. The United States and the University of Groningen lead in publication volume and international collaborations, with H.J.L. Heerspink emerging as a key contributor. While PH remains the dominant research focus, nephrology applications are rapidly increasing, particularly in CKD, diabetic nephropathy (DN), and glomerular diseases. A major milestone was the accelerated FDA approval of sparsentan for IgAN in 2023, followed by full approval in 2024 based on confirmatory efficacy data. However, challenges such as fluid retention and cardiovascular risks remain, necessitating further investigation into optimized ERA therapies, including combination strategies with SGLT2 inhibitors.
    CONCLUSIONS: The expanding role of ERAs in nephrology underscores their potential in treating proteinuric kidney diseases. Ongoing international collaborations are advancing research on ERA safety, efficacy, and novel therapeutic strategies, supporting their broader clinical application.
    Keywords:  Endothelin A receptor antagonists; bibliometric analysis; chronic kidney disease; diabetic nephropathy; focal segmental glomerulosclerosis; hypertension
    DOI:  https://doi.org/10.1080/0886022X.2025.2487212
  57. Explor Res Clin Soc Pharm. 2025 Jun;18 100592
       Introduction: Adverse Drug Reactions (ADRs) pose significant health and economic burdens, yet underreporting and inconsistent standards persist. Digital health innovations, particularly mobile and web-based ADR reporting applications, offer potential to enhance pharmacovigilance by improving data accuracy and patient-reported outcomes.
    Objectives: The study provides a comprehensive mapping of ADR mobile and web application literature, analysing publication trends, key contributors, and core themes through bibliometric and NLP-based content analysis.
    Methods: A systematic two-stage approach was applied to 289 Web of Science articles on ADR reporting applications. Bibliometric analysis explored publication trends, co-authorship networks, and keyword occurrences, while NLP-based topic modelling identified prevalent themes, ensuring thematic coherence and interpretability.
    Results: Bibliometric analysis showed a rise in ADR application-related publications, primarily from the United Kingdom, United States of America, and Switzerland. Content analysis identified ten key themes, including pharmacovigilance, chemotherapy adherence, and psychiatry research. A distinct focus on digital tools in ADR reporting and management was evident, with keywords such as "mobile," "application," and "patient" becoming increasingly prominent in recent years. Co-authorship and collaboration networks, however, showed limited cross-national research partnerships.
    Discussion: The study highlights the transformative role of digital solutions in pharmacovigilance, demonstrating the potential of ADR applications to enhance reporting accuracy and improve patient safety. However, adoption remains early-stage and fragmented by regional affiliations. Future research should focus on patient-centric app development, effectiveness assessment, and fostering global collaboration. Strengthening digital literacy and robust investment in ADR reporting applications is crucial for optimizing their impact in healthcare.
    Keywords:  Adverse drug reaction; Bibliometrics; Content analysis; Natural language processing; Pharmacovigilance; Web application
    DOI:  https://doi.org/10.1016/j.rcsop.2025.100592
  58. F1000Res. 2025 ;14 5
      The evolution of information technologies has led to a significant increase in information security risks, underscoring the urgent need for professional education in this field to safeguard organizational data. Publications on this topic highlight the necessity of educating individuals about data security, and their number has grown in recent years. This study aims to identify thematic trends in information security education through a bibliometric analysis based on five research questions, following PRISMA guidelines. Ninety-nine documents from Scopus and Web of Science were analyzed, revealing a quadratic growth, with 2023 as the year of greatest research activity. Prominent contributors such as Von Solms, Safa, and Furnell stand out, along with the journal Computers & Security and the significant influence of the United States in this field. The potential is identified in the following areas: information security culture, media, information security regulations, higher education institutions, information security management, and cybersecurity. The study also identifies gaps and proposes a research agenda to address these gaps.
    Keywords:  Information security; cybersecurity; data protection; higher education; information security training
    DOI:  https://doi.org/10.12688/f1000research.159828.2
  59. Yi Chuan. 2025 Apr;47(4): 399-408
      Genetics, as a core discipline of life sciences, has broad applications in medicine, agriculture, and environmental protection. With the rapid development in biotechnology, genetic education is facing new challenges and demands. Traditional teaching models have gradually revealed limitations in cultivating students' innovative abilities, practical skills, and comprehensive qualities. To enhance the quality and effectiveness of genetic education, promoting educational reform has become a focal point for educators and researchers. This study employs bibliometric methods to comprehensively review and analyze 690 relevant publications on genetic education reform from 1986 to 2023, encompassing both domestic and international contexts. The analysis covers multiple dimensions, including the time distribution of publications, research topics, major research institutions and authors, and keyword co-occurrence. Results indicate a steady annual growth in research on genetic education reform. Keyword analysis reveals prominent themes such as "educational reform", "experimental education" and "medical genetics", focusing on innovative teaching methods and improving educational outcomes. High-output institutions are primarily found in the fields of agriculture and life sciences, particularly within agricultural universities and the life sciences of comprehensive universities. Here, we summarize the current state and development trends in genetic education reform, providing a scientific basis and reference for future research. This study will promote the innovative development of genetic education and cultivate more high-quality talents with innovative spirit and practical abilities.
    Keywords:  bibliometric analysis; experimental teaching; genetic education reform; innovation in teaching methods; research hotspots and trends
    DOI:  https://doi.org/10.16288/j.yczz.24-292
  60. Front Neurol. 2025 ;16 1486548
       Background: Insomnia is a widespread sleep disorder that significantly affects the quality of life and contributes to immune dysfunction, which in turn leads to chronic diseases. Despite extensive research on sleep disturbances and immune modulation, the relationship between insomnia and immune responses remains underexplored.
    Objectives: The primary objective of this study was to conduct a bibliometric analysis to explore the interaction between immune cells and insomnia, identifying key immune responses involved and their potential roles in the development of insomnia and associated comorbidities.
    Methods: A bibliometric analysis was conducted using data from the Web of Science Core Collection (WoSCC), focusing on research articles published between 2000 and 2023. The analysis aimed to identify trends, key research areas, and the role of immune system cells (T cells, B cells, NK cells, etc.) in insomnia.
    Results: The analysis revealed that various immune cells, including T cells, B cells, NK cells, neutrophils, and monocytes, play crucial roles in insomnia pathogenesis. These immune cells contribute to immune modulation and inflammatory responses, which are linked to sleep disturbances. The study also identified that insomnia is closely associated with comorbidities such as cardiovascular diseases, obesity, depression, and cancer, all of which involve immune dysfunction. The regulation of the immune system was found to be a key factor in improving sleep quality.
    Conclusion: This study provides valuable insights into the complex interaction between the immune system and insomnia. The findings underscore the importance of immune regulation in the treatment of insomnia, suggesting that future research should focus on integrating immune modulation into therapeutic strategies for insomnia. Further studies are needed to explore targeted therapies for immune-related insomnia and its comorbidities, emphasizing interdisciplinary research in this area.
    Keywords:  B cells; T cells; autoimmune encephalitis; comorbid; insomnia; natural killer cells
    DOI:  https://doi.org/10.3389/fneur.2025.1486548
  61. J Oral Pathol Med. 2025 Apr 09.
       BACKGROUND: Oral submucous fibrosis (OSF) is a chronic progressive fibrosis of oral mucosa, with the possibility of eventually progressing to oral cancer, remaining unclear pathogenesis, and a lack of targeted therapies. This study aims to analyze current research progress from a bibliometric perspective to guide the way forward.
    METHODS: Documents in the Web of Science Core Collection database from 1999 to August 31, 2023 were thoroughly searched using a given query. After selection, years of publishing, countries, institutions, authors, journals, and keywords were analyzed using bibliometric software.
    RESULTS: The bibliometric results of 1522 documents show that India and China were the most productive countries in this field. Central South University has published the most papers. The Journal of Oral Pathology & Medicine and Oral Oncology were the leading journals. Betel nut, oral cancer, malignant transformation, and fibroblast were the main focuses during recent study periods. We also analyzed differences between studies in betel chewing and nonchewing areas. Notably, scholars pay more attention to the pathogenesis of OSF in the former, while the relationship between OSF and cancer is more concerning in the latter, such as in the United Kingdom and the United States.
    CONCLUSION: Findings from this study provide an overview of the current research and reveal the future hotspot of the OSF research. It suggests that exploring the pathogenesis and mechanisms of malignant transformation in OSF will be a focal point in future research. Advancements in the prevention and treatment of OSF could significantly enhance patients' quality of life and reduce mortality associated with oral cancer.
    Keywords:  Oral potentially malignant disorders; Oral submucous fibrosis; betel nut; bibliometric; fibroblast; oral cancer
    DOI:  https://doi.org/10.1111/jop.13637
  62. Braz Oral Res. 2025 ;pii: S1806-83242025000100453. [Epub ahead of print]39 e041
      In this study, citations, altmetric scores, and field-normalized impact of articles investigating resin-based adhesives, luting agents, or restorative composites were investigated. Articles published in 2019 on resin-based dental materials indexed in Scopus were searched and assessed by independent investigators. Data collected in 2023 included several article variables and, as outcomes, citation in Scopus and Google Scholar, Altmetric Attention Scores (AAS), and Field-Weighted Citation Impact (FWCI). Data were analyzed using stepwise backward quasi-Poisson regression models (p < 0.05). A total of 707 articles were included, which evaluated restorative composites (58.3%), adhesives (27.2%), and luting agents (19.5%). The majority of corresponding authors were from Asia/Oceania (42.2%), with publications mainly subscription-based (54%) and lacking international collaboration (68.5%). Only 1.4% reported conflicts of interest, and 47.7% did not disclose sponsorship. Median citations were 7 in Scopus and 13 in Google Scholar, whereas the median FWCI was 1. The majority of articles had an AAS of zero. Multivariate analysis showed study sponsorship type and journal CiteScore influenced citations, while COI and the author's continent impacted AAS and FWCI, respectively. Articles on luting agents were less likely to receive citations. The report of conflict of interest was associated with approximately 18 times higher AAS values. This study emphasizes the significance of the type of resin-based material, journal CiteScore, authors' continent, and type of sponsorship in affecting citations, visibility, and impact of scientific articles. Research on luting agents may need better dissemination strategies for increased visibility. The substantial effect of COI presence underscores the importance of transparency.
    DOI:  https://doi.org/10.1590/1807-3107bor-2025.vol39.041
  63. Front Digit Health. 2025 ;7 1557467
       Background: Type 2 Diabetes Mellitus (T2DM) remains a critical global health challenge, necessitating robust predictive models to enable early detection and personalized interventions. This study presents a comprehensive bibliometric and systematic review of 33 years (1991-2024) of research on machine learning (ML) and artificial intelligence (AI) applications in T2DM prediction. It highlights the growing complexity of the field and identifies key trends, methodologies, and research gaps.
    Methods: A systematic methodology guided the literature selection process, starting with keyword identification using Term Frequency-Inverse Document Frequency (TF-IDF) and expert input. Based on these refined keywords, literature was systematically selected using PRISMA guidelines, resulting in a dataset of 2,351 articles from Web of Science and Scopus databases. Bibliometric analysis was performed on the entire selected dataset using tools such as VOSviewer and Bibliometrix, enabling thematic clustering, co-citation analysis, and network visualization. To assess the most impactful literature, a dual-criteria methodology combining relevance and impact scores was applied. Articles were qualitatively assessed on their alignment with T2DM prediction using a four-point relevance scale and quantitatively evaluated based on citation metrics normalized within subject, journal, and publication year. Articles scoring above a predefined threshold were selected for detailed review. The selected literature spans four time periods: 1991-2000, 2001-2010, 2011-2020, and 2021-2024.
    Results: The bibliometric findings reveal exponential growth in publications since 2010, with the USA and UK leading contributions, followed by emerging players like Singapore and India. Key thematic clusters include foundational ML techniques, epidemiological forecasting, predictive modelling, and clinical applications. Ensemble methods (e.g., Random Forest, Gradient Boosting) and deep learning models (e.g., Convolutional Neural Networks) dominate recent advancements. Literature analysis reveals that, early studies primarily used demographic and clinical variables, while recent efforts integrate genetic, lifestyle, and environmental predictors. Additionally, literature analysis highlights advances in integrating real-world datasets, emerging trends like federated learning, and explainability tools such as SHAP (SHapley Additive exPlanations) and LIME (Local Interpretable Model-agnostic Explanations).
    Conclusion: Future work should address gaps in generalizability, interdisciplinary T2DM prediction research, and psychosocial integration, while also focusing on clinically actionable solutions and real-world applicability to combat the growing diabetes epidemic effectively.
    Keywords:  artificial intelligence (AI); bibliometric analysis; machine learning (ML); predictive models; type 2 diabetes mellitus (T2DM)
    DOI:  https://doi.org/10.3389/fdgth.2025.1557467
  64. Adv Colloid Interface Sci. 2025 Apr 04. pii: S0001-8686(25)00115-0. [Epub ahead of print]341 103504
      Hydrogen-bonded organic frameworks (HOFs) are widely used in environmental and energy fields because of their high crystallinity, solution processability, and easy regeneration. Although there have been some reviews focusing on the specific environmental or energy applications of HOFs, a comprehensive research summary and analysis of research trends across the entire field is still lacking. To facilitate the advancement of HOFs, a bibliometric analysis method was used to examine all relevant literature on the subject. Initially, the general bibliometric distribution of the dataset by year, country, institute, reference source, and research focus are determined. Subsequently, the research hotspots covering adsorption, separation, sensing, catalysis, and energy storage are thoroughly explored. To conclude, an analysis of the potential opportunities and obstacles that lie ahead for HOFs is presented, offering a novel perspective to propel their advancement in the fields of environmental remediation and energy utilization.
    Keywords:  Bibliometric analysis; Energy storage; Environmental remediation; Hydrogen-bonded organic frameworks
    DOI:  https://doi.org/10.1016/j.cis.2025.103504
  65. Int J Gynaecol Obstet. 2025 Apr 11.
      There is no formal or standard measure of quality, clinical impact, and scientific merit in the current literature in gynecologic oncology besides formal citation metrics. We aimed to develop and implement a multiparametric score to identify influential articles with transformative impact in gynecology oncology. We conducted a systematic search using PubMed from January 2010 to December 2022 for gynecologic oncology publications. Publications were ranked based on citations per year, top 100 were selected. After excluding 17, 83 original articles were included. A multiparametric score (SciMet) was developed to assess its relevance and impact considering citations per year, journal impact factor, study design, sample size, and altmetric attention score; numeric scores were assigned based on quartiles. This scoring system was applied to articles with citations per year values above the median (39 articles). Thirty-nine studies were analyzed based on the score. Number of CPY ranged from 42.7 to 261.2; journal IF, from 17.76 to 202.7; and sample size from 20 to 1 672 983. The total SciMet score ranged from 17 to 47 (median of 34). The top 10 included studies addressed screening interventions for ovarian cancer, PARP inhibitors and bevacizumab use as first-line maintenance in ovarian cancer, surgical trials in cervical cancer, and HPV vaccination impact on cervical intraepithelial neoplasia or cancer development. Articles with higher scores were mostly randomized clinical trials, and besides having high metrics, led to changes in management of gynecologic cancers, resulting in their incorporation into guidelines that shape established norms in the field.
    Keywords:  bibliometrics; female; genital neoplasms; manuscript; medical; ovarian neoplasms; uterine cervical neoplasms
    DOI:  https://doi.org/10.1002/ijgo.70147
  66. Cytopathology. 2025 Apr 10.
       OBJECTIVE: Using bibliometric analysis to inform factors impacting career mobility, focusing on gender and regional variations in academic cytopathology.
    METHODS: The Scopus database was used to determine the productivity and experience of cytopathologists who are faculty from the 92 fellowship programs. The dependent variable was promotion to the rank of Professor. A regression analysis was conducted with productivity (h-index), experience (years in publication) and one's geographic work location as covariates to investigate the role of gender in promotion.
    RESULTS: The gender distribution is skewed towards females at the Assistant (62.4% vs. 37.58%) and Associate Professors (70.51% vs. 29.49%) levels, but the gap narrows at the full-professor rank (52.98% vs. 47.02%). The regression model showed significant regional variation in promotion for the Southern (0.35; 95% CI, 0.16-0.79; p = 0.012) and Northeastern (0.24; 95% CI, 0.10-0.57; p = 0.001) regions compared to the West. Active years of publishing (1.18; 95% CI, 1.11-1.27; p < 0.001) and productivity (1.09; 95% CI, 1.06-1.12; p < 0.001) were factors in promotion. The mean HI productivity was comparable between the males and females in the first (4.41 for males and 4.40 for females) and the second decade (13.81 for males and 12.84 for females). However, the gap widened into the third decade (30.27 for males and 26.40 for females), suggesting potential areas for improvement.
    CONCLUSION: While the academic cytopathology workforce is progressing towards gender equity, there is still room for improvement. Our findings suggest that focusing on mid-career professionals(between the second to third decades) by providing additional resources for research and facilitating work-life flexibility can help close the gender gap at the highest level.
    Keywords:  academic promotion; career advancement; cytopathology; equity; h‐index; productivity; regional variation
    DOI:  https://doi.org/10.1111/cyt.13490
  67. Discov Oncol. 2025 Apr 10. 16(1): 508
       BACKGROUND: Lung cancer remains the leading cause of cancer-related deaths worldwide, with increasing attention being given to novel therapeutic strategies that target the mechanisms underlying tumor growth and drug resistance. Among these, ferroptosis, a regulated cell death driven by iron-dependent lipid peroxidation, has become a key focus in cancer research. Despite extensive research, the exact role of ferroptosis in lung cancer progression and treatment remains unclear, especially regarding its interaction with immune cells and the tumor microenvironment.
    OBJECTIVE AND METHODS: To address these limitations, this study utilizes a comprehensive bibliometric analysis to explore the current landscape of ferroptosis research in lung cancer. We collected data from the Web of Science Core Collection, covering articles published between 2015 and 2025, and analyzed them using advanced tools such as VOSviewer and CiteSpace.
    RESULTS: This study uses a comprehensive bibliometric analysis to uncover key trends and emerging areas related to lung cancer in ferroptosis research. Recently, the focus has shifted from basic mechanisms to clinical applications, particularly in developing GPX4-targeted therapies and combination treatments. With increasing international collaboration, the United States and China have become key players. Interdisciplinary research, especially on ferroptosis and the cancer-immune system, offers new insights into its role in the tumor microenvironment and immunotherapy. Ferroptosis shows excellent promise in overcoming drug resistance by regulating iron-dependent lipid peroxidation and enhancing treatment efficacy. Future research should focus on ferroptosis' clinical translation, particularly in personalized medicine and overcoming resistance, offering broad prospects for lung cancer treatment.
    CONCLUSION: This paper provides valuable insights into the trends, key contributors, and emerging frontiers of ferroptosis research in lung cancer. It identifies important developments that can serve as a foundation for translating ferroptosis-based therapies into clinical practice, particularly to address drug resistance in lung cancer.
    Keywords:  Drug resistance; Ferroptosis; GPX4 inhibitors; Immunotherapy combination; Lung cancer therapy
    DOI:  https://doi.org/10.1007/s12672-025-02234-7
  68. BMJ Health Care Inform. 2025 Apr 05. pii: e101244. [Epub ahead of print]32(1):
       OBJECTIVES: This study analyses the trend of artificial intelligence (AI)-related publications in the medical field over the past decade and demonstrates the potential of AI in automating data analysis. We hypothesise exponential growth in AI-related publications, with continuous growth in the foreseeable future.
    METHODS: Retrospective, AI-assisted analysis was conducted using the OpenAI application programming interface for data collection and evaluation. Publications from the top 50 medical journals (Web of Science, Journal Citation Report, 2022) covering 2014 to June 2024. A total of 315 209 papers were initially retrieved with 212 620 remaining after filtering. The outcomes were the total number and percentage of AI-related publications per year, with future trends prediction using statistical models.
    RESULTS: AI-related publications increased from approximately 500 in 2014 to over 1000 in 2022, with the percentage rising from 2.5% to over 6% in 2024. The analysis identified cardiology and oncology as leading in AI adoption. Predictive models forecast that AI-related publications could reach 10% by 2030 with long-term projections suggesting potential dominance of AI presence by the mid-22nd century.
    DISCUSSION: The study highlights the significant growth and integration of AI in medical research, with cardiology and oncology at the forefront. AI-assisted data analysis proves efficient and scalable but requires human oversight to maintain credibility.
    CONCLUSIONS: The trajectory of AI-related publications indicates substantial growth and future integration across medical disciplines. Ongoing evaluation of AI's reliability and applicability in medical research remains essential.
    Keywords:  Artificial intelligence; Medical Informatics
    DOI:  https://doi.org/10.1136/bmjhci-2024-101244
  69. Int J Biol Macromol. 2025 Apr 02. pii: S0141-8130(25)03350-1. [Epub ahead of print]309(Pt 1): 142798
      Nanozymes, a new generation of artificial enzymes, have attracted significant attention in biomedical applications due to their multifunctional properties, multi-enzyme mimicking abilities, cost-effectiveness, and high stability. Leveraging these diverse catalytic activities, an increasing number of nanozyme-based therapeutic strategies have been developed for the treatment of various diseases. Despite substantial research efforts, a significant gap remains in comprehensive studies examining the progression, key areas, current trends, and future directions in this field. This study provides a comprehensive overview of nanozyme applications in biomedical research over the past 17 years, utilizing data from the Web of Science Core Collection, covering the period from January 1, 2007, to October 8, 2024. Advanced bibliometric and visualization tools were employed to facilitate a comprehensive analysis. The results highlight China's dominant role in this field, accounting for 76.83 % of total publications, significantly influencing the evolution of research in this area. Key contributions were made by institutions such as the Chinese Academy of Sciences, the University of Chinese Academy of Sciences, and the University of Science and Technology of China, with Qu Xiaogang as the leading author. The journal ACS Applied Materials & Interfaces has become the most prolific publisher in this field. Keyword analysis indicates that since 2022, research hotspots in this field have increasingly focused on areas such as photothermal therapy, chemodynamic therapy, and ferroptosis. Challenges such as obstacles to clinical translation, limitations in recyclability, and insufficient targeting ability were addressed. The potential applications of emerging interdisciplinary technologies, such as artificial intelligence, machine learning, and organoids, in advancing nanozyme development were explored. This study offers a data-driven roadmap for researchers to navigate the evolving landscape of nanozyme innovation, emphasizing interdisciplinary collaboration in impactful biomedical applications.
    Keywords:  Current frontiers; Enzyme mimetics; Graphical analysis; Hot topics; Nanomaterials
    DOI:  https://doi.org/10.1016/j.ijbiomac.2025.142798
  70. PLoS One. 2025 ;20(4): e0321425
      The NIHR provides two main funding pathways: 'commissioned' (CP) and 'researcher-led' (RLP) projects. CPs are used to ensure NHS priorities are addressed. However, there is uncertainty regarding which provides the highest quality, best value for money, research. We compared the quality and cost of commissioned and research-led projects. We searched the NIHR Funded Portfolio database for randomised controlled trials (RCTs) funded by programmes offering both CP and RLP funding. The main outcome was journal impact factor for the main results paper. Other outcomes included: Altmetric score, relative citation ratio, total and per participant funding. T-tests were used to compare mean values. 82 eligible RCTs were identified, 30 commissioned and 52 researcher-led. One RLP did not progress beyond pilot; two (one CP and one RLP) did not publish a monograph; and 78 published main study results in a peer-reviewed journal. Among these, RLP projects had higher means scores than CP projects for: journal impact factor (111.2 and 40.8, respectively, p < 0.001); Altmetric score (223.8 and 116.8, p = 0.05); and relative citation ratio (8.0 and 4.4, p = 0.06). Among the full 82 RCTs, RLP mean total study and per participant funding were lower than CP: £1,429,913 vs. £1,353,034, p = 0.59; and £11,271 vs. £4425, p = 0.08. Researcher-led projects are more likely to result in higher impact research compared with commissioned studies. Further research is needed to understand the reasons, which could include: commissioned research addressing harder-to-do questions; commissioning brief quality; and/or research team motivation.
    DOI:  https://doi.org/10.1371/journal.pone.0321425
  71. AI Soc. 2025 ;40(2): 1091-1111
      Autonomous vehicles (AV) offer promising benefits to society in terms of safety, environmental impact and increased mobility. However, acute challenges persist with any novel technology, inlcuding the perceived risks and trust underlying public acceptance. While research examining the current state of AV public perceptions and future challenges related to both societal and individual barriers to trust and risk perceptions is emerging, it is highly fragmented across disciplines. To address this research gap, by using the Web of Science database, our study undertakes a bibliometric and performance analysis to identify the conceptual and intellectual structures of trust and risk narratives within the AV research field by investigating engineering, social sciences, marketing, and business and infrastructure domains to offer an interdisciplinary approach. Our analysis provides an overview of the key research area across the search categories of 'trust' and 'risk'. Our results show three main clusters with regard to trust and risk, namely, behavioural aspects of AV interaction; uptake and acceptance; and modelling human-automation interaction. The synthesis of the literature allows a better understanding of the public perception of AV and its historical conception and development. It further offers a robust model of public perception in AV, outlining the key themes found in the literature and, in turn, offers critical directions for future research.
    Keywords:  Autonomous vehicles; Bibliometric analysis; Risk; Trust
    DOI:  https://doi.org/10.1007/s00146-024-01895-2
  72. Food Chem. 2025 Apr 01. pii: S0308-8146(25)01357-3. [Epub ahead of print]482 144106
      This paper presents the first bibliometric review on the application of smartphone-based digital images in food matrices, conducted specifically using the Bibliometrix package in R. Although there are already reviews on the topic, this is the first to employ a quantitative approach based on bibliometric methods, analyzing 125 articles published between 2013 and 2024 and identified in the Web of Science. The retrieved works were written by 431 researchers and published in 38 journals across 33 countries, demonstrating an annual growth rate of 45.92 %. The results reveal that a substantial portion of the articles focus on adulteration detection and substance quantification in a practical, cost-effective, and accessible manner. More than 60 % of the studies did not use chemometric tools. Among the studies that did, the most frequently employed were Partial Least Squares Regression (PLS), Principal Component Analysis (PCA), Hierarchical Cluster Analysis (HCA), and Multiple Linear Regression (MLR).
    Keywords:  Chemometrics; Colorimetry; Foods; Quantification; RGB
    DOI:  https://doi.org/10.1016/j.foodchem.2025.144106
  73. Jpn Dent Sci Rev. 2025 Dec;61 55-78
      Nanoimaging, crucial in endodontics, has advanced, leading to more effective and less invasive treatments. Nano-computed tomography (nano-CT) is an advanced imaging technique to evaluate bone structures or gaps in filling materials, providing submicrometer spatial resolution due to smaller focal points and voxels, higher signal-to-noise ratios, and higher tube voltages and powers compared to conventional devices, improving dental imaging precision and safety by producing detailed images with minimal radiation exposure. This study conducted a bibliometric analysis on nano-CT imaging as a nano identification tool in endodontics. Using various tools and methods, it evaluated progress and trends in nano-CT, aiming to enhance understanding of bibliometric data and complement existing endodontic knowledge. Nano-CT imaging has gained prominence in endodontics research, offering potential applications and insights into various aspects of the field. A review of relevant studies highlighted the technique's ability to visualize dentin tubules, root canal anatomy, filling quality, root resorption, cracks, microcracks, soft dental tissues, cellular layers, volumetric changes post-instrumentation, hard tissue debris, root surface deposits, and bioceramic pore structures. Nano-CT has the potential to become the gold standard for imaging in endodontics, presenting opportunities and challenges for future research. These findings provide researchers and practitioners with the latest advancements in nanoimaging.
    Keywords:  Advanced imaging; Bibliometrics; Endodontics; Nano-CT; Nano-computed tomography
    DOI:  https://doi.org/10.1016/j.jdsr.2025.03.003
  74. JBI Evid Synth. 2025 Apr 01. 23(4): 564-565
      
    DOI:  https://doi.org/10.11124/JBIES-24-00522
  75. J Korean Med Sci. 2025 Apr 07. 40(13): e47
       BACKGROUND: The proportion of women doctors has been rising globally and South Korea mirrors this trend. Despite this growth, women doctors' representation in leadership roles in academic medical fields remains scarce. This study investigates the representation and trends of women doctors' leadership in editorial boards of South Korean medical journals, and compares the gender ratio of specialists.
    METHODS: This non-clinical data analysis examined the editorial boards of 45 major medical academic journals published in 2015, 2020, and 2024 to investigate women leadership within journal editorial boards, compares the gender ratio of specialists, and observed changes over time.
    RESULTS: The study included data from 1,475 members in 2015, 1,598 in 2020, and 2,531 in 2024. In 2020, 23.8% of specialists were women, but only 19.5% of editorial board members were women (P < 0.001). Nine journals had less than 10% women representation on their editorial boards. Over nine years, women representation on editorial boards increased from 16.8% in 2015 to 21.3% in 2024 (P = 0.001), with significant increases in societies of clinical medicine (14.6% vs. 20.0%; P < 0.001) but not in basic medicine. Journals with women editors-in-chief had significantly higher women representation on their boards compared to ones with male editors-in-chief (36.7 ± 13.5% vs. 18.4 ± 10.9%, P < 0.001). The proportion of women senior editorial roles and that of women executive society members showed a significant positive correlation with the proportion of women on editorial boards (P < 0.001 and P < 0.001, respectively).
    CONCLUSION: The study highlights the considerable underrepresentation of women in editorial leadership compared to their presence as specialists. However, the number of women editorial board members has increased over the past decade, especially in clinical medicine. Women doctors' leadership positively correlates with higher women participation on boards, which suggests that promoting women leaders could enhance gender diversity in academic medicine. Further qualitative research is needed to explore the impact of women doctors' leadership on medical research and patient outcomes. This study provides critical insights into gender disparities in South Korean medical academia and underscores the need for policies to promote women doctors' leadership.
    Keywords:  Editor; Editorial Board; Female; Gender Equity; Korea; Leadership; Workforce Diversity
    DOI:  https://doi.org/10.3346/jkms.2025.40.e47
  76. Nanomaterials (Basel). 2025 Mar 28. pii: 507. [Epub ahead of print]15(7):
      Graphene oxide (GO), a pivotal derivative of graphene, has revolutionized nanotechnology with its tunable physicochemical properties and interdisciplinary applications in energy storage, environmental remediation, and biomedicine. Despite its exponential research growth, existing reviews remain fragmented, lacking holistic insights into evolving synthesis-application linkages, global collaboration patterns, and emerging convergence trends. This study bridges these gaps through a scientometric analysis of 14,124 peer-reviewed articles (2022-2025) from the Web of Science Core Collection, utilizing CiteSpace for co-occurrence network mapping, burst detection, and cluster analysis. Key findings reveal (1) a thematic shift from traditional synthesis optimization (e.g., Hummers' method) toward driven material design and sustainable applications like GO membranes for water purification; (2) China's dominance in publication output (38.5%) contrasts with the U.S. and Europe's leadership in global collaborations; (3) interdisciplinary journals such as Chemical Engineering Journal (centrality: 0.25) and emerging clusters like "circular economy" signal transformative priorities; and (4) critical gaps in scalability, ecological safety, and cost-effective production hinder industrial translation. This work provides a roadmap for aligning research with sustainability goals, fostering global partnerships, and accelerating innovations in scalable nanotechnology.
    Keywords:  CiteSpace; applications; graphene oxide; scientometrics; synthesis
    DOI:  https://doi.org/10.3390/nano15070507
  77. Sci Rep. 2025 Apr 08. 15(1): 12011
      Research trend analysis is a primary step in defining research structures and predicting research directions from scientific papers. Recently, due to millions of annual scientific publications, researchers demand analytical methods to interpret the research field topologically and temporally. In this study, we propose a keyword-based research trend analysis method that automatically and systematically analyzes the research field by extracting keywords and constructing a keyword network. We verified our method on the resistive random-access memory (ReRAM) research field, which is in the limelight as an alternative device for non-volatile memory and artificial synapses. Our method performs three sequential processes: article collection, keyword extraction, and research structuring. We identified three keyword communities of ReRAM based on the processing-structure-property-performance (PSPP) relationship and found an upward trend in Neuromorphic applications. As a result, our method successfully structures the ReRAM research field and is expected to provide detailed insights into various research fields.
    Keywords:  Bibliometrics; Materials science; Natural Language processing; Network theory; ReRAM; Research trend analysis
    DOI:  https://doi.org/10.1038/s41598-025-93423-5
  78. Nat Hum Behav. 2025 Apr 11.
      Retracting academic papers is a fundamental tool of quality control, but it may have far-reaching consequences for retracted authors and their careers. Previous studies have highlighted the adverse effects of retractions on citation counts and the citations of co-authors; however, the broader impacts beyond these have not been fully explored. Here we address this gap by leveraging Retraction Watch, the most extensive dataset on retractions and link it to Microsoft Academic Graph and Altmetric. Retracted authors, particularly those with less experience, often leave scientific publishing in the aftermath of a retraction, especially if their retractions attract widespread attention. However, retracted authors who remain active in publishing maintain and establish more collaborations compared with their similar non-retracted counterparts. Nevertheless, retracted authors generally retain less senior and less productive co-authors, but gain more impactful co-authors post-retraction. Our findings suggest that retractions may impose a disproportionate impact on early career authors.
    DOI:  https://doi.org/10.1038/s41562-025-02154-0
  79. Adv Pharm Bull. 2024 Dec 30. 14(4): 722-728
       Purpose: Hijacked journals are fraudulent websites that mimic legitimate journals and, by charging authors, publish manuscripts. The current editorial endeavors to provide a close view of current literature. This editorial piece analyzes 10 years of research on hijacked journals and endeavors to shed light on future trends.
    Methods: Current research uses a bibliometric approach to analyze data and discuss results. The OpenAlex has been used for data collection. Some of the data analysis was conducted using OpenAlex. The other study was done using Bibliometrix, and the date is limited to publication between 2014 and 2024.
    Results: The findings provide a close view of the published literature in terms of access type, growth, topics, most frequent words, country contribution, top publishers, and alignment of literature with sustainable development goals.
    Conclusion: The gap in current literature is the limitation in easily usable methods to be accessible by all researchers for hijacked journal detection and data analysis. The use of artificial intelligence can be promising.
    Keywords:  Artificial intelligence; Bibliometrics; Circular economy; Circular society; Hijacked journals; Medicine; Publication ethics; Sustainable development goals
    DOI:  https://doi.org/10.34172/apb.44002
  80. Eur J Pediatr Surg. 2025 Apr 04.
       OBJECTIVE:  This study aims to assess publishing trends, motivations, preferences, and challenges among pediatric surgeons globally.
    METHODS:  A cross-sectional survey was conducted among pediatric surgeons from multiple countries, distributed through the Trainees of European Pediatric Surgery (TEPS) network and social media. The anonymous questionnaire contained 26 items focusing on journal preferences, motivations for publishing, obstacles faced, peer-review experiences, open access publishing, and methods of research dissemination.
    RESULTS:  A total of 172 responses were collected from pediatric surgeons in 33 countries. Most respondents worked in tertiary hospitals (88%) and were consultants or senior attendings (49%). Over half (65%) had published at least one scientific paper in the last 3 years. PubMed was the primary search engine (82%), and pediatric surgical journals were the preferred outlets for publication (87%). Key motivations for choosing a journal were impact factor (22%) and scope (19%), while publication costs (38%) and slow review processes (22%) were the primary deterrents. Open access publication options were used by more than half of respondents, with a third spending less than €2,500 on fees. Social media, particularly Instagram, emerged as a popular platform for research dissemination.
    CONCLUSION:  Pediatric surgeons prefer publishing in specialized journals, with impact factor and scope being key drivers of journal choice. Publication costs and the peer-review process are the most significant obstacles. Efforts to address these challenges, such as reducing fees and enhancing the review process, are crucial for facilitating research dissemination in pediatric surgery.
    DOI:  https://doi.org/10.1055/a-2544-9739
  81. Health Sci Rep. 2025 Apr;8(4): e70626
       Background and Aims: Breast cancer is the most common cancer and a leading cause of cancer-related death among women globally. Determining which patients will benefit from chemotherapy remains challenging. Proliferative markers such as Ki-67, mini chromosome maintenance (MCM) proteins, and proliferating cell nuclear antigen (PCNA) offer valuable insights into tumor growth and treatment response. This review evaluates their clinical roles, with a focus on chemotherapy implications and emerging digital pathology techniques for marker quantification.
    Methods: A narrative review was conducted by searching PubMed, Scopus, and Google Scholar for studies related to Ki-67, MCM, PCNA, breast cancer, and chemotherapy. Studies were thematically categorized into five areas. A bibliometric analysis of publications from 2000 to April 2023 was performed using the Bibliometrix R package and VOSviewer to assess research trends and thematic evolution.
    Results: Eighty studies were included in the narrative synthesis. Ki-67 is the most commonly used marker, particularly useful in predicting response to neoadjuvant chemotherapy (NAC). MCM proteins show promise for identifying proliferative potential across tumor grades, while PCNA is associated with aggressive tumor features and poor prognosis. Post-chemotherapy changes in Ki-67 levels are linked to survival outcomes. Bibliometric analysis revealed a shift in research focus from basic mechanisms to clinical applications and digital quantification.
    Conclusion: Proliferative markers play an essential role in breast cancer management. Ki-67 remains a key predictor of chemotherapy response, while MCM and PCNA offer complementary prognostic insights. Integration of these markers with digital pathology and AI-driven tools may enhance diagnostic accuracy and personalized treatment strategies. Standardization of assessment methods is crucial for broader clinical application.
    Keywords:  Ki‐67; MCM; PCNA; bibliometric analysis; breast cancer; chemotherapy
    DOI:  https://doi.org/10.1002/hsr2.70626
  82. Acad Radiol. 2025 Apr;pii: S1076-6332(24)00674-3. [Epub ahead of print]32(4): 2334-2341
       RATIONALE AND OBJECTIVES: Radiology is a dynamic and ever-evolving field, necessitating research and innovation. However, the conventional medical training model falls short in fostering research skills, crucial for cultivating the upcoming cohort of physician-scientists. Our radiology residency research track (RT) was instituted to offer a dedicated research pathway, to foster the next generation of research-focused academic radiologists. The track provides an integrated 4-year longitudinal curriculum and academic time. This study assessed the impact and progress of our RT over 12 years.
    MATERIALS AND MATERIALS: Using publicly available online data from Doximity, PubMed, and Scopus we collected information on all graduates from our Diagnostic and Interventional Radiology residency program graduation classes between 2010 and 2022, including most recent job position, position type (academic vs. private), and publications. We compared RT and non-research track (NRT) residents.
    RESULTS: Out of 185 graduates, 179 profiles (97%) were retrievable, including all 13 RT residents. The average number of publications per resident during residency was 1.1 (186 total) for NRT graduates and 7.2 (93 total) for RT graduates (p < 0.001). Throughout their entire careers to date, NRT graduates averaged 7.3 publications per resident (1249 total), while RT graduates averaged 31.7 publications per resident (412 total) (p < 0.001). The average number of citations per graduate was 123 (21212 total) for NRT and 552 (7175 total) for RT (p < 0.001). Additionally, 36% of NRT graduates and 92% of RT graduates (p = 0.005) held academic job positions.
    CONCLUSION: Residents from the radiology residency research track were more likely to assume academic positions and had a higher number of publications and citations per resident compared to their non-research track counterparts, suggesting the track serves as an effective pipeline for cultivating academic radiologists.
    Keywords:  Academic Career; Research Track; Residency; Resident Education
    DOI:  https://doi.org/10.1016/j.acra.2024.09.025
  83. Int Health. 2025 Apr 08. pii: ihaf032. [Epub ahead of print]
       BACKGROUND: The increasing frequency and severity of wildfires, exacerbated by climate change, population growth and land use changes, have escalated public health risks. These events are associated with respiratory and cardiovascular diseases and adverse mental health outcomes. Vulnerable populations, including children, older people and those with pre-existing health conditions, face particularly high risks.
    METHODS: This study evaluates the existing literature on wildfire-related health impacts. Key variables include publication frequency, geographic distribution, collaborative networks and funding patterns.
    RESULTS: Findings reveal a concentration of research in high-income regions, particularly North America and Europe, with limited studies from wildfire-prone but under-represented areas such as Latin America, Oceania, Africa and the Caribbean. This geographical disparity restricts comprehensive understanding and effective public health responses to wildfire impacts. The analysis also underscores the need for interdisciplinary approaches.
    CONCLUSIONS: Wildfires continue to pose significant global public health challenges. There is a critical need for more inclusive research efforts, enhanced international collaboration and a stronger focus on health-specific outcomes, especially in under-represented regions. Expanding research in these areas is essential to inform effective public health policies and interventions that address the health risks posed by wildfires worldwide.
    Keywords:  bibliometric analysis; exposure; future directions; human health; research trends; wildfire
    DOI:  https://doi.org/10.1093/inthealth/ihaf032
  84. J Educ Perioper Med. 2025 Jan-Mar;27(1):27(1): E737
       Background: Based on a review of anesthesiology education articles published in 2021, the authors conducted a critical appraisal to describe trends in the literature, highlight innovations in the field, and identify high-yield articles for clinician educators in anesthesiology.
    Methods: After a database search (3 Ovid MEDLINE databases, Embase.com, ERIC [via FirstSearch], PsycINFO [via EBSCOhost], and PubMed), abstracts were screened by 2 independent reviewers based on inclusion criteria. Articles representing publications in both anesthesiology-specific journals and general medical education journals were included via manual search. Three randomly assigned raters reviewed and scored each quantitative article using a rubric. Two raters scored qualitative studies using a separate rubric designed for qualitative studies. Each article also received an overall quality rating used to create an additional list of recommended articles.
    Results: The database search identified 1141 articles and an additional manual search identified 1497 articles. Of these, 67 articles met the inclusion criteria (61 quantitative, 6 qualitative). This article reports and summarizes the top 13 quantitative articles and top 2 qualitative papers.
    Conclusions: This year we did not see as many articles describing curriculum to teach learners procedures, a topic heavily present in previous years. Also, analysis revealed an increase in articles focused on nontechnical skill education and a trend toward how to assess learner performance. Finally, 2 articles focused on gender issues in anesthesiology, an emerging area of interest.
    Keywords:  Medical education; anesthesiology; bibliometric; literature review; research
    DOI:  https://doi.org/10.46374/VolXXVII_Issue1_Chen
  85. Spine J. 2025 Apr 05. pii: S1529-9430(25)00191-3. [Epub ahead of print]
       BACKGROUND CONTEXT: Understanding optimal training environments for future academic leaders is a topic of increasing interest in spine surgery.
    PURPOSE: This study determined the association between surgeon factors and future academic faculty appointment after spine surgery fellowship training.
    STUDY DESIGN/SETTING: This was a retrospective observational study of spine surgery fellows in the United States (2016-2017 to 2022-2023).
    PATIENT SAMPLE: N/A OUTCOME MEASURES: The primary outcome of interest was future academic faculty appointment, which was assigned if the spine surgeon was employed at a teaching hospital. Demographic, bibliometric, and training characteristics of spine surgery fellows were obtained.
    METHODS: Bivariate analyses were performed to determine the association between surgeon factors and future academic faculty appointment.
    RESULTS: There were 654 spine surgery fellows and 243 were appointed to academic faculty positions (37.2%). There was no difference in the rate of future academic faculty appointment between male and female spine surgeons (36.7% vs 45.7%, P=0.368). Allopathic graduates were more likely to obtain academic faculty positions than osteopathic graduates (40.6% vs 12.5%, P<0.001). Compared to spine surgeons in private practice, spine surgeons in academic practice had more peer-reviewed publications during medical school (1 ± 3 vs 0 ± 2, P<0.001) and orthopaedic surgery residency training (5 ± 13 vs 3 ± 5, P<0.001). Several characteristics of spine surgery fellowship programs were associated with future academic faculty appointment including geographic region (P=0.013), Accreditation Council for Graduate Medical Education (ACGME) accreditation status (P<0.001), and a greater volume of annual fellows (P=0.003).
    CONCLUSIONS: Several factors were associated with future academic faculty appointment in spine surgery including higher scholarly output during medical school and orthopaedic residency. These data may ultimately help trainees and fellowship selection committees in spine surgery align on desired academic career objectives.
    Keywords:  academic; career; faculty; fellowship; orthopaedic; spine; surgery
    DOI:  https://doi.org/10.1016/j.spinee.2025.04.005
  86. PLoS One. 2025 ;20(4): e0320148
      Many studies have investigated anchoring effects. Anchoring occurs when initial values are used by humans as starting points in assessments. We investigated the prevalence of anchoring effects in the quality assessments of scientific papers. This study, which is preregistered, is a follow-up study that is intended to answer open questions from a previous study with the same topic. One open question concerns causal conclusions: it is necessary that randomly selected respondents assess the same paper under different conditions. In a survey, we asked corresponding authors to assess the quality of articles they have cited in previous papers. The respondents were randomly assigned to several experimental groups receiving numerical anchors such as citation counts or numerical access codes to the questionnaire. Although our results reveal scarcely effects of citation counts presented to the respondents as possible anchors, there is a small, but statistically significant effect of the random number (the numerical access code) presented to the respondents. Similar to other studies that have investigated the existence of anchoring effects in assessments in various contexts, our study could demonstrate the existence of an anchoring effect in research evaluation. Researchers seem to be influenced by numbers without any relationship to the quality of the evaluated paper in their assessment of papers.
    DOI:  https://doi.org/10.1371/journal.pone.0320148
  87. J Patient Saf. 2025 Apr 14.
       OBJECTIVES: This study aimed to comprehensively analyze patient safety research in the field of nursing over the past 20 years to identify key research topics and emerging trends.
    METHODS: Structural topic modeling, a text mining methodology to identify latent topics from large volumes of unstructured textual data, was conducted on 6072 articles published in the Ovid Medline, Ovid Embase, Cumulative Index to Nursing and Allied Health Literature, and PubMed databases from January 2000 to April 2023. Based on the structural topic modeling results, we performed the Mann-Kendall trend test and conducted community detection.
    RESULTS: The analysis identified 39 unique topics, which were categorized into 4 communities: medication safety, structure, processes, and outcomes. Interest in patient safety culture, patient safety education, and qualitative research methodologies has been increasing, while traditional topics such as medical error analysis and nurse staffing have shown a decreasing trend.
    CONCLUSIONS: The scope of patient safety research in the field of nursing is gradually expanding, with an evident shift in research focus. Our findings provide crucial information for setting future research directions and advancing nursing practice and policy, ultimately contributing to improvements in patient safety.
    Keywords:  data mining; natural language processing; nursing research; patient safety
    DOI:  https://doi.org/10.1097/PTS.0000000000001347