bims-evares Biomed News
on Evaluation of research
Issue of 2025–01–26
ninety-two papers selected by
Thomas Krichel, Open Library Society
  1. Forty years of research trends in long-acting injectable antipsychotics: A bibliometric analysis.
  2. Impacts of intestinal microbiota metabolite trimethylamine N-oxide on cardiovascular disease: a bibliometric analysis.
  3. A bibliometric analysis of 30 years of research on transarterial radioembolization (TARE) for hepatocellular carcinoma.
  4. Research hotspots and future trends in sepsis-associated acute kidney injury: a bibliometric and visualization analysis.
  5. Global research trends in the application of artificial intelligence in oncology care: a bibliometric study.
  6. Quantifying research hotspots and trends in brucella spondylitis: a bibliometric analysis.
  7. Research Prospects for Necroptosis in Inflammatory Diseases: A Bibliometric Analysis.
  8. From disease management to prevention, hip prosthesis joint infections in the past 20 years: a global research trends and top 10 cited articles analysis.
  9. Hotspots and research trends of gut microbiome in polycystic ovary syndrome: a bibliometric analysis (2012-2023).
  10. Mapping the intellectual structure and emerging trends on nanomaterials in colorectal cancer: a bibliometric analysis from 2003 to 2024.
  11. Global research landscape and emerging trends of non-coding RNAs in prostate cancer: a bibliometric analysis.
  12. Influential articles in autism and gut microbiota: bibliometric profile and research trends.
  13. A bibliometric analysis of the development trend of Tuina research: Based on the Web of Science (WOS) platform.
  14. Current trends in pain management: A bibliometric analysis for the 1980-to-2023 period.
  15. A bibliometric analysis of optic atrophy from 2003 to 2023: research trends and hot spots.
  16. The research progress and prospects of circadian rhythm in obesity: a bibliometric analysis.
  17. Research progress of breast cancer surgery during 2010-2024: a bibliometric analysis.
  18. Awake Craniotomy in Neurosurgery: A Bibliometric Analysis of the Top 100 Most-Cited Articles and Review of Technological Advancements.
  19. Evolutionary patterns and research frontiers of artificial intelligence in age-related macular degeneration: a bibliometric analysis.
  20. Global vaccine research and application hotspots and trends: a systematic bibliometric analysis based on SCIE highly cited papers.
  21. Mapping Trends Regarding the Cardiopulmonary Resuscitation: A Bibliometric Analysis of the Top 100 Cited Articles.
  22. Global research status and trends of somatic symptom disorder: A bibliometric study.
  23. Trends and advances in Leptospira, a bibliometric analysis.
  24. Research progress of early brain Injury in subarachnoid hemorrhage from 2004 to 2024: a bibliometric analysis.
  25. Evolutionary patterns and research frontiers in autophagy in podocytopathies: a bibliometric analysis.
  26. Global research trends on nanotechnology and colorectal cancer: a two-decade analysis.
  27. Research focus and theme evolution on enhanced external counterpulsation: A bibliometric analysis.
  28. Research hotspots and trends in lung cancer STAS: a bibliometric and visualization analysis.
  29. Current Status and Future Trends in Myocarditis Related to the COVID-19 Vaccines: A Visual and Bibliometric Analysis.
  30. Bibliometric Insights Into Thromboelastography Research Using PubMed and VOSviewer.
  31. It Is a Catch-22 Situation! A Decade of Research Trends on Gay Wellbeing in China: A Bibliometric Analysis.
  32. Bibliometric Analysis of Research on Lip Prints.
  33. Bibliometric analysis of research on the application of deep learning to ophthalmology.
  34. Knowledge development of empowerment in nursing research: A bibliometric analysis using reference publication year spectroscopy.
  35. Research hotspots and frontiers of endoplasmic reticulum in glomerular podocytes: a bibliometric and visual analysis from 2005 to 2023.
  36. Bibliometric analysis on the top one hundred cited studies on gastrointestinal endoscopy.
  37. Mapping the evolution and frontiers of Translational Lung Cancer Research: a bibliometric analysis and literature review.
  38. Current research status and trends of potassium-competitive acid blockers in the treatment of acid-related diseases: a bibliometric analysis.
  39. Global Trends in Studies on the Presence of Demodex spp. in Patients Diagnosed with Blepharitis.
  40. Bibliometric analysis of teen pregnancy research in Asia-Africa: Explore the future scope.
  41. Teaching Spirituality in Nursing: A Bibliometric Analysis.
  42. A Bibliometric Analysis on the Risk Factors of Cancer.
  43. Cardiac surgery outcomes: The efficacy of dexmedetomidine in reducing postoperative delirium - A bibliometric study.
  44. Bibliometric and visual analysis of chronic stress in cancer research from 2014 to 2024.
  45. Gut microbiota and inflammasome-mediated pyroptosis: a bibliometric analysis from 2014 to 2023.
  46. Global Research Trends in Cervical Cancer Survival in the Last Two Decades: A Bibliometric Analysis.
  47. Metabolic response to burn injury: a comprehensive bibliometric study.
  48. Comprehensive bibliometric analysis of pharmacotherapy for bipolar disorders: Present trends and future directions.
  49. Bibliometric analysis of metformin as an immunomodulator (2013-2024).
  50. Application of artificial intelligence in the health management of chronic disease: bibliometric analysis.
  51. Large Language Models in Healthcare: A Bibliometric Analysis and Examination of Research Trends.
  52. Osseointegration Process Improving via Functionalization of Titanium Dioxide Nanotubes: A Bibliometric Analysis and Systematic Review.
  53. Article Retraction in Otolaryngology Journals: A Thirty Year Analysis.
  54. Analysis of nanomedicine applications for inflammatory bowel disease: structural and temporal dynamics, research hotspots, and emerging trends.
  55. Current Status and Future Directions of Artificial Intelligence in Post-Traumatic Stress Disorder: A Literature Measurement Analysis.
  56. The top 100 most-cited total knee arthroplasty publications.
  57. Nanoparticles in gynecologic cancers: a bibliometric and visualization analysis.
  58. Investigating Past, Present, and Future Trends on Interface Between Marine and Medical Research and Development: A Bibliometric Review.
  59. Insights into anesthesia administration for elderly individuals undergoing painless gastroenteroscopy: A bibliometric study.
  60. Global landscape of Vibrio parahaemolyticus research: a bibliometric analysis.
  61. Unveiling the conceptual and intellectual map of care bundle research in ICUs: Trends, key issues, and collaborative networks.
  62. Trends in Colorectal Cancer Peritoneal Metastases Research: A Comprehensive Bibliometric Analysis.
  63. School built environment and children's health: a scientometric analysis.
  64. Diversity in the medical research ecosystem: a descriptive scientometric analysis of over 49 000 studies and 150 000 authors published in high-impact medical journals between 2007 and 2022.
  65. Bibliometric Analysis of Probiotic Bacillus in Food Science: Evolution of Research Trends and Systematic Evaluation.
  66. The global trends and distribution in tumor-infiltrating lymphocytes over the past 49 years: bibliometric and visualized analysis.
  67. Application of the Relative Citation Ratio to Assess Common Characteristics of the Highest Impact Articles in Reconstructive Microsurgery.
  68. Response to the Letter to the Editor regarding "Global research trends and hotspots in gestational diabetes and long-term cardiovascular health: A bibliometric analysis."
  69. Patent research in academic literature. Landscape and trends with a focus on patent analytics.
  70. Agriculture data sharing review.
  71. A brief examination of literature on adult cystic fibrosis: An emerging topic.
  72. Research Trends and Development Dynamics of qPCR-based Biomarkers: A Comprehensive Bibliometric Analysis.
  73. Findings on impact of COVID-19 on mental health using keyword visualization.
  74. Retracted articles in endodontic-related literature: an analysis of 60 cases.
  75. Inequality in measuring scholarly success: Variation in the h-index within and between disciplines.
  76. Bibliometric analysis of neurocysticercosis case reports and evaluation of presented cases.
  77. Spin is Prevalent in the Abstracts of Systematic Reviews and Meta-Analyses Comparing Biceps Tenodesis and Tenotomy Outcomes.
  78. Disparities of women's authorship in Colombia: A cross-sectional analysis.
  79. Characterization of academic output (h-index) by Australian urologists according to gender and rurality.
  80. Advances in genetic diagnosis and therapy of hereditary heart disease: a bibliometric review from 2004 to 2024.
  81. Bibliometric mapping of mesenchymal stem cell therapy for bone regeneration from 2013 to 2023.
  82. Global Advancements in Bioactive Material Manufacturing for Drug Delivery: A Comprehensive Study.
  83. Global Trends in Aesthetic Plastic Surgery Clinical Trials: A Visualization and Bibliometric Analysis (2004-2023).
  84. Female Representation Among Head and Neck Surgical Oncology Publications.
  85. [Gender differences in scientific publications].
  86. Advancements and prospects of molecularly imprinted polymers as chemical sensors: A comprehensive review.
  87. A bibliometric review of functional ingredients and their efficacy in developing functional biscuits.
  88. The publication fate of abstracts awarded prizes at European Society of Paediatric Radiology annual scientific meetings.
  89. The Impact of International Fellowship on Research Productivity: International Fellowship on Research Productivity.
  90. Are Women Physicians Underrecognized for National Awards in Neuromuscular and Electrodiagnostic Medicine? An Observational Study.
  91. Research Funded by National Institutes of Health Concerning Sexual and Gender Minoritized Populations: A Tracking Update for 2012 to 2022.
  92. Postdoc publications and citations link to academic retention and faculty success.
  1. Australas Psychiatry. 2025 Jan 20. 10398562251313929
    Forty years of research trends in long-acting injectable antipsychotics: A bibliometric analysis.
    Alper Mert, Tugce Soyleyici Mert.
       BACKGROUND: Using long-acting injectable (LAI) antipsychotics is crucial for treating psychiatric illnesses, particularly those within the schizophrenia spectrum. Through bibliometric analysis, our study aimed to provide an understanding of the changes in research trends related to LAIs over the past 40 years.
    METHODS: We collected the publications from 1983 to 2023 related to research studies on LAIs included in the Web of Science database. Two thousand four hundred and twelve publications were selected based on specific criteria and analyzed using the VOSviewer software and the Biblioshiny app. We obtained and presented data on institutional analysis, country analysis, author and co-authorship analysis, journal analysis, funding agencies, and keyword citation numbers.
    RESULTS: From the period 1983-1992 to 2014-2023, the number of total publications showed a significant growth of 4.91. The majority (approximately 90%) of publications were produced in high-income countries. The private sector may play a significant role in research. The most crucial keywords were schizophrenia and risperidone.
    CONCLUSIONS: The trend in LAI research is currently dynamic and ongoing. There seems to be an increasing connection between studies and LAIs that contain second-generation antipsychotics. The number of studies relating to the private sector is noteworthy.
    Keywords:  antipsychotic; bibliometric analysis; long-acting injectable antipsychotic; relapse; schizophrenia
    DOI:  https://doi.org/10.1177/10398562251313929
  2. Front Microbiol. 2024 ;15 1491731
    Impacts of intestinal microbiota metabolite trimethylamine N-oxide on cardiovascular disease: a bibliometric analysis.
    Xiaohui Leng, Xiunan Wei, Jun Wang, Xiaodong Yao, Miaomiao Zhang, Dajuan Sun, Junwei Liang, Lili Chi, Yan Cheng.
       Background: Trimethylamine N-oxide (TMAO), a metabolite dependent on intestinal microbiota, is closely related to the emergence, progression, and prognosis of cardiovascular disease (CVD), and has received increasing attention in recent years.
    Objective: The current research hotspots and future development trends in TMAO and CVD field are found through bibliometrics analysis, which provides reference for further study.
    Methods: The bibliometrics tools VOSviewer and CiteSpace were used to analyze the publications from the Web of Science Core Collection (WOSCC) database. The articles published from 2004 to 2024 about the relationship between TMAO and CVD were retrieved. Bibliometric analysis includes annual publications, countries/regions, institutions, authors and co-cited authors, journals and cited-journals, references and keywords.
    Results: After searching and screening, 1,466 publications were included for subsequent bibliometric analysis. Since 2014, the number of publications exposing the relationship between TMAO and CVD has increased rapidly, as has the frequency of citations. China, USA and Italy are the countries that publish the most relevant research. Cleveland Clinic is the leading institution in this field. Stanley L Hazen, Zeneng Wang and W H Wilson Tang are the most prolific authors in this field, and the latter two have the closest academic cooperation. American Journal of Clinical Nutrition and Journal of the American Heart Association are influential journals that publish research in this field. "Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk" is the most frequently cited article. Keyword analysis shows that gut microbiota, metabolism, phosphatidylcholine and atherosclerosis (AS) are the hotspots in this field.
    Conclusion: This study summarizes the research situation of TMAO and CVD in the past 20 years, focusing on the effect of TMAO on pathogenesis of AS, predictive value of TMAO on CVD risk, and dietary and drug intervention for TMAO. Probiotics and natural products may be the research focus of preventing and treating CVD by intervening TMAO in the future.
    Keywords:  atherosclerosis; bibliometric analysis; cardiovascular disease; gut microbiota; inflammation; microbiota metabolite; trimethylamine N-oxide
    DOI:  https://doi.org/10.3389/fmicb.2024.1491731
  3. Front Pharmacol. 2024 ;15 1449722
    A bibliometric analysis of 30 years of research on transarterial radioembolization (TARE) for hepatocellular carcinoma.
    Tongyao Hu, Qifan Xu, Guorong Jia, Tao Wang, Changjing Zuo.
       Introduction: Patients with advanced hepatocellular carcinoma (HCC) have very limited treatment options, among which transarterial radioembolization (TARE) receives increasing attention, relying on its promising efficacy and fewer side effect. However, a bibliometric analysis of TARE for HCC is still lacking. This study employed bibliometric methods to analyze the related articles over the past three decades, and aimed to identify trends in clinical research comparing TARE to other treatments.
    Methods: Articles related with TARE for HCC were obtained from the Web of Science (WoS). After screening, the R package Bibliometrix was employed to explore the primary bibliometric characteristics. The number of publications was analyzed and mathematically fitted to a curve using Microsoft Excel 2021 and SPSS 25, and then was plotted in the graph using GraphPad Prism 8.0. VOSviewer, SCImago Graphica, and Pajek were utilized for the analysis of researchers' co-authorship, co-occurrence, and visualization. Keywords citation burst was detected by CiteSpace software.
    Results: A total of 1,110 articles from 1993 to 2023 were included in our final analysis, among which the United States not only ranked the first in term of the number of published articles, also was at the forefront in other important indicators, including the total number of article citations and the average citation frequency. Riad Salem from Northwestern University, also being the organization with the greatest number of research papers, was the most active author and has published 96 papers. The keywords were classified into three clusters: 90Y microspheres for TARE, Basic research on TARE, and Clinical trial of TARE for HCC. Furthermore, we identified the most frequently cited keywords with strong citation bursts since 2020 were "multicenter," "overall survival" and "PET/CT."
    Conclusion: Our study employed a bibliometric approach to achieve the visualization research on TARE for HCC, and further revealed the trends and frontiers of TARE research, providing valuable information for researchers to identify the critical and persistent challenges and select potential partners in related area. Based on our analysis, future research focus include the clinical comparative studies on the effect of TARE and TACE combined with immunotherapies or targeted therapy, dosimetry, and personalized TARE therapy for HCC.
    Keywords:  90Y microspheres; bibliometric analysis; hepatocellular carcinoma (HCC); research trend; transarterial radioembolization (TARE); visualization
    DOI:  https://doi.org/10.3389/fphar.2024.1449722
  4. Front Med (Lausanne). 2024 ;11 1456535
    Research hotspots and future trends in sepsis-associated acute kidney injury: a bibliometric and visualization analysis.
    Xing-Yue Chen, Li-Jia Zhi, Jun Chen, Rong Li, Kun-Lan Long.
       Objectives: Sepsis-associated acute kidney injury (SA-AKI) commonly occurs in critically ill patients and is closely associated with adverse outcomes. A comprehensive analysis of the current research landscape in SA-AKI can help uncover trends and key issues in this field. This study aims to provide a scientific basis for research directions and critical issues through bibliometric analysis.
    Methods: We searched all articles on SA-AKI indexed in the SCI-Expanded of WoSCC up to May 7, 2024, and conducted bibliometric and visual analyses using bibliometric software CiteSpace and VOSviewer.
    Results: Over the past 20 years, there has been a steady increase in literature related to renal repair following AKI. China and the United States contribute over 60% of the publications, driving research in this field. The University of Pittsburgh is the most active academic institution, producing the highest number of publications. J. A. Kellum is both the most prolific and the most cited author in this area. "Shock" and "American Journal of Physiology-Renal Physiology" are the most popular journals, publishing the highest number of articles. Recent high-frequency keywords in this field include "septic AKI," "mitochondrial dysfunction," "inflammasome," "ferroptosis," and "macrophage." The terms "mitochondrial dysfunction," "inflammasome," "ferroptosis," and "macrophage" represent current research hotspots and potential targets in this area.
    Conclusion: This is the first comprehensive bibliometric study to summarize the trends and advancements in SA-AKI research in recent years. These findings identify current research frontiers and hot topics, providing valuable insights for scholars studying SA-AKI.
    Keywords:  CiteSpace; VOSviewer; acute kidney injury; bibliometrics; sepsis
    DOI:  https://doi.org/10.3389/fmed.2024.1456535
  5. Front Oncol. 2024 ;14 1456144
    Global research trends in the application of artificial intelligence in oncology care: a bibliometric study.
    Mianmian Xu, Yafang Chen, Tianen Wu, Yuyan Chen, Wanling Zhuang, Yinhui Huang, Chuanzhen Chen.
       Objective: To use bibliometric methods to analyze the prospects and development trends of artificial intelligence(AI) in oncology nursing from 1994 to 2024, providing guidance and reference for oncology nursing professionals and researchers.
    Methods: The core set of the Web of Science database was searched for articles from 1994 to 2024. The R package "Bibliometrix" was used to analyze the main bibliometric features, creating a three-domain chart to display relationships among institutions, countries, and keywords. VOSviewer facilitated co-authorship analysis and its visualization was used for co- occurrence analysis. CiteSpace calculated citation bursts and keyword occurrences.
    Results: A total of 517 articles were retrieved, representing 80 countries/regions. The United States had the highest number of publications, with 188 articles (36.4%), followed by China with 79 articles (15.3%). The top 10 institutions in terms of publication output were all U.S.-based universities or cancer research institutes, with Harvard University ranking first. Prominent research teams, such as those led by Repici, Aerts, and Almangush, have made significant contributions to studies on AI in tumor risk factor identification and symptom management. In recent years, the keywords with the highest burst strength were "model" and "human papillomavirus." The most studied tumor type was breast cancer. While Cancers published the highest number of articles, journals such as CA: A Cancer Journal for Clinicians and PLOS ONE had higher impact and citation rates.
    Conclusion: By analyzing the volume of AI literature in oncology nursing, combined with the statistical analysis of institutions, core authors, journals, and keywords, the research hotspots and trends in the application of AI in oncology nursing over the past 30 years are revealed. AI in oncology nursing is entering a stage of rapid development, providing valuable reference for scholars and professionals in the field.
    Keywords:  CiteSpace; VOSviewer; artificial intelligence; bibliometrics; cancer prevention; hot topics; oncology nursing
    DOI:  https://doi.org/10.3389/fonc.2024.1456144
  6. Front Surg. 2024 ;11 1465319
    Quantifying research hotspots and trends in brucella spondylitis: a bibliometric analysis.
    Zhangui Gu, Zongqiang Yang, Le Fei, Daihao Wei, Long Ma, Qiang Liu, Jiandang Shi.
       Background: Human brucellosis is the most common bacterial zoonosis worldwide, with brucella spondylitis (BS) being one of its most severe forms, potentially leading to spinal deformity or paralysis. This study aims to provide a comprehensive overview of the current status and research trends in the BS field using bibliometric methods.
    Methods: Publications on BS from January 1, 1980, to March 24, 2024, were retrieved from the Web of Science database. We used Biblioshiny, VOSviewer, Scimago Graphica, CiteSpace, and Microsoft Office Excel Professional Plus 2016 to analyze publication frequency, geographic distribution, institutional affiliations, international collaborations, authorship, journal sources, keyword usage, trends, and cited references.
    Results: Between January 1, 1980, and March 24, 2024, 197 publications on BS were analyzed. Turkey emerged as the leading contributor, with 62 publications, accounting for 31.47%. Weibin Sheng was the most prolific author, contributing 7 papers (3.55%). Xinjiang Medical University was the leading institution with 13 documents (6.60%). Medicine and Rheumatology International each published 6 papers (3.05%). CiteSpace analysis highlighted "spinal brucellosis," "spondylitis," "complications," "diagnosis," and "involvement" as the core research areas in BS. Keyword clustering analysis identified 11 primary clusters representing the main research directions. Analysis of abstracts and keyword trends revealed that post-2020, emerging research frontiers include "instrumentation," "management," and "debridement."
    Conclusion: There has been significant progress in BS research, with a steady increase in publications. Current research focuses on diagnosis and complications, while future studies may explore management and instrumentation. Increased collaboration among countries and researchers is recommended.
    Keywords:  bibliometric analysis; brucella spondylitis; management; research trends; spinal infections
    DOI:  https://doi.org/10.3389/fsurg.2024.1465319
  7. Curr Med Chem. 2025 Jan 22.
    Research Prospects for Necroptosis in Inflammatory Diseases: A Bibliometric Analysis.
    Ya Ting Tan, Mei Juan Wang, Shu Chao Wang.
       BACKGROUND: Necroptosis is a modifiable form of cell death mainly dependent on RIPK3 and MLKL. The association between necroptosis and inflammation has been a key focus of research. An increasing number of studies have shown that necroptosis plays an important role in inflammatory diseases, such as inflammatory bowel disease.
    METHODS: Articles published up to 2023 were searched on the Web of Science. VOSviewer, CiteSpace, Gephi, and Microsoft Office Excel were used for bibliometric analysis and visualisation. In addition, journal impact factors and journal partitions were obtained through the Web of Science.
    RESULTS: A total of 3011 articles were included in this study. The number of publications and citations in the field increased year by year. China had the highest number of publications. Cell Death & Disease published the most papers in the field. P. Vandenabeele is one of the most important scholars in this field. The most cited reference was "Molecular Mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death".We found substantial evidence that acute kidney injury, sepsis, cancer, and other diseases are closely related to necroptosis. In addition, we found that inhibitors of necroptosis have great potential in the treatment of inflammatory diseases.
    CONCLUSION: This is the first bibliometric analysis of studies related to necroptosis in inflammatory diseases. Our results provide an overview of basic and influential research, providing a basis for the identification of valuable research directions. Furthermore, this work offers general insight into the role of necroptosis in inflammatory human diseases.
    Keywords:  Necroptosis; VOSviewer.; bibliometrics; cell death; citespace; inflammation
    DOI:  https://doi.org/10.2174/0109298673336964250103060730
  8. Front Surg. 2024 ;11 1448049
    From disease management to prevention, hip prosthesis joint infections in the past 20 years: a global research trends and top 10 cited articles analysis.
    Fei-Long Li, Xing-Yu Qi, Jin-Lun Chen, Yi-Rong Zeng.
       Background: There are few literatures comprehensively analyzed the global research in hip prosthesis joint infections (HPJI). We aim to clarify the global research trends and analysis the top 10 cited articles in the HPJI field.
    Methods: We identified the core collection of articles/reviews in the HPJI field from 2001 to 2021 through the Web of Science Core Collection (WOSCC). VOSviewer and online bibliometric tool were used to conduct the visualized and knowledge maps. Annual trends of publications, research hotspots and the top 10 cited articles were analyzed.
    Results: A total of 5,477 publications were finally included. Generally, an increasing trend was observed in the number of publications from 2001 to 2021. The authors, journals and institutions with largest number of publications all belong to the USA. Co-occurrence analysis of keywords showed that surgical techniques, risk factors, revision surgery strategy, epidemiology, diagnoses and prevention were the 6 major research directions. Total hip arthroplasty, replacement, outcomes, risk factors and diagnosis were the keywords that occurred most frequently. The top 10 cited articles were all published in Journal Citation Reports (JCR) Q1 journals, providing valuable reference value from the perspectives of clinical guidelines, perioperative management, causes and diagnostic methods of infection, epidemiological investigation, risk factors and prognostic analysis.
    Conclusions: The number of publications in HPJI field had been on the rise over the past 20 years, from disease management to prevention. An intensive reading of the top 10 cited articles is beneficial to understand the focus of HPJI research comprehensively.
    Keywords:  bibliometric analysis; highly cited articles background; hip; prosthesis joint infections; research trends
    DOI:  https://doi.org/10.3389/fsurg.2024.1448049
  9. Front Microbiol. 2024 ;15 1524521
    Hotspots and research trends of gut microbiome in polycystic ovary syndrome: a bibliometric analysis (2012-2023).
    Ruishan Wu, Zhensheng Mai, Xiaoyan Song, Wenzhong Zhao.
       Introduction: Polycystic ovary syndrome (PCOS) is a common gynecological condition affecting individuals of reproductive age and is linked to the gut microbiome. This study aimed to identify the hotspots and research trends within the domain of the gut microbiome in PCOS through bibliometric analysis.
    Methods: Utilizing bibliometric techniques, we examined the literature on the gut microbiome in PCOS from the Web of Science Core Collection spanning the period from 2012 to 2023. Analytical tools such as CiteSpace, VOSviewer, and Bibliometric R packages were employed to evaluate various metrics, including countries/regions, institutions, authors, co-cited authors, authors' H-index, journals, co-references, and keywords.
    Results: A total of 191 publications were identified in the field of gut microbiome in PCOS, with an increase in annual publications from 2018 to 2023. People's Republic of China was the most productive country, followed by the United States of America (USA), India. Shanghai Jiao Tong University, Fudan University, and Beijing University of Chinese Medicine were the top three most publications institutions. Thackray VG was identified as the most prolific author, holding the highest H-index, while Liu R received the highest total number of citations. The journal "Frontiers in Endocrinology" published the most articles in this domain. The most frequently co-cited reference was authored by Qi XY. The analysis of keyword burst detection identified "bile acids" (2021-2023) as the leading frontier keyword. Additionally, "gut dysbiosis," "phenotypes," "adolescents," "metabolomics," "metabolites," "fecal microbiota transplantation," and "IL-22" have emerged as the primary keywords reflecting recent research trends.
    Conclusion: This bibliometric analysis explores how the gut microbiome influences endocrine and metabolic disorders related to PCOS, emphasizing its role in the development of PCOS and treatments targeting the gut microbiome. The findings serve as a valuable resource for researchers, enabling them to identify critical hotspots and emerging areas of investigation in this field.
    Keywords:  CiteSpace; VOSviewer; bibliometric; gut microbiome; pathogenesis; polycystic ovary syndrome (PCOS); treatment
    DOI:  https://doi.org/10.3389/fmicb.2024.1524521
  10. Front Oncol. 2024 ;14 1514581
    Mapping the intellectual structure and emerging trends on nanomaterials in colorectal cancer: a bibliometric analysis from 2003 to 2024.
    Man Lu, Yi Liu, Jin Zhu, Jiarong Shang, Lu Bai, Zhichao Jin, Wenting Li, Yue Hu, Xia Zheng, Jun Qian.
       Background: Colorectal cancer (CRC) is one of thes most prevalent malignant tumors worldwide. Current therapeutic strategies for CRC have limitations, while nanomaterials show significant potential for diagnosing and treating CRC. This study utilizes bibliometric analysis to evaluate the current status and trends in this field.
    Methods: Research on nanomaterials in CRC from 2003 to 2024 was retrieved from the Web of Science Core Collection (WOSCC). Tools such as CiteSpace, VOSviewer, RStudio, GraphPad Prism, and Excel were used to analyze trends and hotspots, covering publication trends, countries, institutions, authors, journals, co-citation analysis, and keywords. Visual maps were created to forecast future developments.
    Results: The analysis includes 3,683 publications by 17,261 authors from 3,721 institutions across 100 countries/regions, published in 840 journals. Global publications have steadily increased, particularly since 2018. China leads in publication volume and citations, with six of the top ten research institutions and seven of the ten most cited authors, while the United States excels in citation impact and academic centrality. Both countries currently dominate the field, underscoring the urgent need for enhanced international collaboration. Ramezani M and Abnous K lead in publication volume and H-index, while Siegel RL is highly cited. The International Journal of Nanomedicine has the highest publication volume, while the Journal of Controlled Release is the most cited. In addition to "colorectal cancer" and "nanoparticles," the most common keyword is "drug delivery." Emerging research areas such as "metal-organic frameworks (MOFs)" and "green synthesis" are gaining attention as leading hotspots.
    Conclusion: This study offers an in-depth analysis of the application of nanomaterials in CRC, promoting interdisciplinary collaboration and advancing scientific progress in this field.
    Keywords:  R-bibliometrix; bibliometric analysis; colorectal cancer; nanomaterial; research trends; visualization
    DOI:  https://doi.org/10.3389/fonc.2024.1514581
  11. Front Pharmacol. 2024 ;15 1483186
    Global research landscape and emerging trends of non-coding RNAs in prostate cancer: a bibliometric analysis.
    Yu-Liang Zhou, Wen-Liang Yao, Sheng-Hui Chen, Peng Wang, Jing-Wen Fu, Jia-Qin Zhao, Jia-Yi Zhang.
       Background: Prostate cancer (PC) is the most frequently diagnosed cancer in men and continues to be a major cause of cancer-related mortality worldwide. In recent years, non-coding RNAs (ncRNAs) have emerged as a significant focus in molecular biology research, playing a pivotal role in the development and progression of PC. This study employed bibliometric analysis to explore the global outputs, research hotspots, and future trends in ncRNA-related PC research over the past 20 years.
    Methods: Publications on PC-related ncRNAs from 2004 to 2023 were retrieved from Web of Science Core Collection. The co-operation network of countries, institutions, and authors on this topic was analyzed using CiteSpace (version 6.2. R6). In addition, co-occurrence analysis of keywords and co-citation analysis of references were performed using CiteSpace, and emergent detection was also performed.
    Results: A total of 2,951 articles on PC-related ncRNAs were finally included in this study for analysis. China contributed the largest number of publications, while the United States was the most influential country in this field, with collaborative ties to 26 other countries. Fudan University was identified as the most active institution in this field. Rajvir Dahiya was the most prolific and influential author. Within the co-citation network, clusters labeled "EVs," "circRNA," and "ceRNA" represented current research directions. The cluster labeled "gene" dominated the co-occurrence keywords. "circRNA" showed the highest burst strength among keywords, with "circRNA," "EVs" and "exosome" maintaining sustained burst strength, suggesting these are the emerging research frontiers in this field.
    Conclusion: Investigating ncRNAs as pivotal research subjects in PC is essential for addressing the public health impact of the disease and advancing innovative diagnostic and targeted therapeutic strategies. This study provides a comprehensive bibliometric analysis of research related to PC-associated ncRNAs, delivering a scientific perspective and identifying potential research directions for scholars in this field.
    Keywords:  bibliometric analysis; circular RNA; extracellular vesicle; non-coding RNA; prostate cancer
    DOI:  https://doi.org/10.3389/fphar.2024.1483186
  12. Front Microbiol. 2024 ;15 1401597
    Influential articles in autism and gut microbiota: bibliometric profile and research trends.
    Jiangbo Ying, Melvyn Weibin Zhang, Ker-Chiah Wei, Sunny H Wong, Mythily Subramaniam.
       Objective: Autism spectrum disorder (ASD) is a common neurodevelopmental disorder. Increasing evidence suggests that it is potentially related to gut microbiota, but no prior bibliometric analysis has been performed to explore the most influential works in the relationships between ASD and gut microbiota. In this study, we conducted an in-depth analysis of the most-cited articles in this field, aiming to provide insights to the existing body of research and guide future directions.
    Methods: A search strategy was constructed and conducted in the Web of Science database to identify the 100 most-cited papers in ASD and gut microbiota. The Biblioshiny package in R was used to analyze and visualize the relevant information, including citation counts, country distributions, authors, journals, and thematic analysis. Correlation and comparison analyses were performed using SPSS software.
    Results: The top 100 influential manuscripts were published between 2000 and 2021, with a total citation of 40,662. The average number of citations annually increased over the years and was significantly correlated to the year of publication (r = 0.481, p < 0.01, Spearman's rho test). The United States was involved in the highest number of publications (n = 42). The number of publications in the journal was not significantly related to the journal's latest impact factor (r = 0.016, p > 0.05, Spearman's rho test). Co-occurrence network and thematic analysis identified several important areas, such as microbial metabolites of short-chain fatty acids and overlaps with irritable bowel syndrome.
    Conclusion: This bibliometric analysis provides the key information of the most influential studies in the area of ASD and gut microbiota, and suggests the hot topics and future directions. The findings of this study can serve as a valuable reference for researchers and policymakers, guiding the development and implementation of the scientific research strategies in this area.
    Keywords:  autism; bibliometric analysis; citations; gut microbiota; research trends
    DOI:  https://doi.org/10.3389/fmicb.2024.1401597
  13. Medicine (Baltimore). 2025 Jan 17. 104(3): e41070
    A bibliometric analysis of the development trend of Tuina research: Based on the Web of Science (WOS) platform.
    Lin Gao, Suyu Chen, Tianlei Gao, Liuying Yang, Xiantao Tai.
       BACKGROUND: Tuina has been proven to significantly relieve symptoms, demonstrating its clinical value. With the growth of related research, a comprehensive review is urgently needed to promote its development. This study aims to clarify the collaboration and current research status in the field of Tuina research using bibliometric analysis, and to discuss future directions.
    METHODS: On February 4, 2023, the Web of Science Core Collection (WoSCC) database was searched using the keywords "tuina," "tui-na," "tui na," and "Chinese massage" to collect literature related to Tuina from its inception until December 31, 2022. The collected literature included all types of research articles and reviews. VOSviewer, CiteSpace, Pajek, and Scimago Graphica were utilized to perform a visual analysis of annual publication volume, as well as publication volume and collaboration networks of different countries, institutions, and authors, along with journal publication volume and keyword network analysis.
    RESULTS: A total of 761 publications were included in the analysis, with the total number of papers showed an increasing trend over time. The countries and institutions with the most publications were China and Shanghai University of Traditional Chinese Medicine, respectively. The authors who contributed the most were Min Fang, Qingguang Zhu, Zhiwei Wu, Lingjun Kong and Yufeng Wang. The most widely published journal in the field was the Journal of Acupuncture and Tuina Science. The clinical efficacy evaluation of Tuina therapy for musculoskeletal and spinal diseases, apoplexy sequelae, chronic diseases, and pediatric diseases were research hotspots and developing trends in this field.
    CONCLUSION: The research on Tuina has been increasing year by year. Currently, the focus of Tuina research lies in clinical studies, including the treatment of skeletal muscle and spinal diseases, stroke sequelae, chronic diseases, and pediatric illnesses, with pediatric Tuina emerging as a hot topic of research. Basic research in this field is relatively scarce, and the mechanisms of action of this therapy have not yet been fully elucidated. Future efforts in this area should aim to strengthen basic research and promote cooperation among international institutions.
    DOI:  https://doi.org/10.1097/MD.0000000000041070
  14. Medicine (Baltimore). 2025 Jan 17. 104(3): e41319
    Current trends in pain management: A bibliometric analysis for the 1980-to-2023 period.
    Emre Demir, Güvenç Doğan, Murat Kiraz, Arzu Akdağli Ekici, Selçuk Kayir, Musa Ekici, Gülçin Aydoğdu, Gül Doğan, Tuba Kayir.
      There is currently no bibliometric analysis available regarding pain management (PM). The aim of this study was to monitor the advancement of the PM research field, demonstrate global productivity, identify the most highly cited studies, delineate collaborations between research areas and countries, and uncover new research topics and intriguing trends. A total of 16,216 articles on the subject of PM published between 1980 and 2023 were downloaded from the Web of Science database and analyzed using various bibliometric analysis methods. Trend keyword analysis, thematic evolution analysis, conceptual structure analysis, factor analysis, citation and co-citation analyses, and international collaboration analyses were conducted. The top 3 most active countries were the United States of America (n = 4021), the United Kingdom (n = 791), and Canada (n = 602). The most prolific author was Christine Miaskowski (n = 47). The most researched topics from the past to the present were chronic pain, opioids, analgesia/analgesics, cancer pain, postoperative pain, low back pain, opioid, cancer, acute pain, and self-management. Factor analysis identified key topics such as analgesia and various types of pain in the central factor, with additional subfactors including low back pain and physiotherapy, nursing, and postoperative anxiety and depression. In recent years, starting in 2020, trending research topics have shifted towards e-health, telemedicine, virtual reality, digital health, mental health, peripheral nerve blocks, erector spinae plane blocks, quadratus lumborum blocks, opioid use disorder, buprenorphine, musculoskeletal pain, COVID-19, cervicalgia, and interprofessional collaboration. In addition to Western countries with major economies in the field of PM (USA, Canada, Australia, and European countries), we identified China, India, and Turkey as research leaders. Our bibliometric analysis of 10,566 articles on PM reveals a significant growth in research, with recent trends focusing on e-health, telemedicine, virtual reality, and peripheral nerve blocks. These emerging technologies and personalized treatment approaches are shaping the future of PM.
    DOI:  https://doi.org/10.1097/MD.0000000000041319
  15. Front Med (Lausanne). 2024 ;11 1497446
    A bibliometric analysis of optic atrophy from 2003 to 2023: research trends and hot spots.
    Liyuan Wang, Tianyang Yu, Runze Wang, Lijuan Fu, Feixue Dong, Shuang Zhao, He Sun, Yang Gao.
       Background: Optic atrophy (OA) is primarily caused by damage to the retinal pathway system, including widespread degeneration of retinal ganglion cells and axons, leading to visual impairment and blindness. Despite its clinical significance and diverse etiological factors, there is currently a lack of comprehensive bibliometric analyses exploring research trends and hotspots within this field.
    Method: This study retrieved relevant literature on OA published between 2003 and 2023 from the Web of Science Core Collection database. We conducted a bibliometric analysis using tools such as CiteSpace, VOSviewer, and SCImago Graphica to examine annual publication trends, co-occurrence patterns, collaborative networks among countries and institutions, and the evolution of research hotspots of OA.
    Results: A total of 5,274 publications were included in the bibliometric analysis, comprising 4,561 research articles and 713 review articles. The United States emerged as the leading country in OA research, followed by Germany and China. Over the past two decades, the primary research hotspots focused on "mitochondrial dysfunction," "hereditary optic neuropathy," "ocular hypertension" and "diagnostic techniques." Future research trends are likely to revolve around "molecular mechanisms" and "therapeutic targets."
    Conclusion: This bibliometric analysis provides an overview of research developments in OA over the past 20 years, highlighting the emphasis on the pathological basis of OA and advancements in diagnostic and therapeutic approaches. Future studies should continue to explore the molecular basis of mitochondrial dysfunction to identify potential gene therapy targets for treating OA.
    Keywords:  Web of Science; bibliometric analysis; collaborative network; optic atrophy; research trend
    DOI:  https://doi.org/10.3389/fmed.2024.1497446
  16. Front Nutr. 2024 ;11 1499984
    The research progress and prospects of circadian rhythm in obesity: a bibliometric analysis.
    Ye Dou, Xiaojin Guo, Xuefei Wang, Aolong He, Fanghe Li, Kuo Gao.
       Background: Numerous studies have shown a link between circadian rhythms disruptions and a higher risk of obesity. This article aims to conduct an extensive bibliometric analysis to deepen our understanding of the relationship between circadian rhythms and obesity.
    Methods: The literature related to the circadian rhythm of obesity, published from the inception of the Web of Science Core Collection (WoSCC) until June 30, 2024, was extracted from the WoSCC databases (SCIE, SSCI, ESCI). Using CiteSpace, Vosviewer, WPS, and other software, this paper examines the publication trends, including the number of papers, countries/regions, institutions, authors, journals, references, and keywords.
    Results: A total of 2,870 articles were included in this analysis, revealing a consistent year by year increase in research on the circadian rhythm of obesity. These publications originate from 460 institutions in 88 countries. Among the authors analysis, Garaulet, Marta was the most prolific, and Turek FW was the most co-cited. Proceedings of the National Academy of Sciences of the United States of America emerged as the journal with the highest number of publications, and American Journal of Physiology had the highest centrality. The most frequently used keywords were "obesity," "circadian rhythm," "circadian clock," "metabolic syndrome," "metabolism." Additionally, research areas involving intermittent fasting, restricted feeding, and gut microbiota were rapidly developing and represented the forefront of research on circadian rhythms and obesity.
    Conclusion: Our study demonstrates that research on circadian rhythms in obesity has been rapidly expanding, with increasingly in-depth exploration of the topic. It is recommended to strengthen cooperation between countries and institutions to jointly promote research in this field. The gene expression of obesity is an early hotspot in the study of circadian rhythm and obesity, and emerging research areas such as intermittent fasting, restricted feeding, endothelial nitric oxide synthase and gut microbiota will become significant hotspots and trends in the field of circadian rhythm and obesity. These findings provide researchers critical directions for future studies and may have significant implications for clinical practice and public health policy.
    Keywords:  CiteSpace; VOSviewer; bibliometric analysis; circadian rhythm; obesity; visualization
    DOI:  https://doi.org/10.3389/fnut.2024.1499984
  17. Front Oncol. 2024 ;14 1508568
    Research progress of breast cancer surgery during 2010-2024: a bibliometric analysis.
    Jiawei Kang, Nan Jiang, Munire Shataer, Tayier Tuersong.
       Purpose: This study seeks to systematically analyze the research literature pertaining to breast cancer surgery from 2010 to 2024, as indexed in the PubMed database, employing bibliometric methodologies.
    Methods: Employing the "bibliometrix" package in the R programming language, alongside VOSviewer and CiteSpace software, this research conducted a comprehensive visual analysis of 1,195 publications. The analysis encompassed publication trends, collaborative networks, journal evaluation, author and institutional assessments, country-specific analyses, keyword exploration, and the identification of research hotspots.
    Results: The study observed a rising trend in the number of publications related to breast cancer surgery. However, there was a concomitant decline in citation rates, potentially indicating either a saturation of the research field or a diminution in research quality. The United States, China, and Japan are the leading contributors to research output, with the United States showing the most extensive international collaboration. The University of California, University of Toronto, and University of Texas MD Anderson Cancer Center were the top institutions for the number of published papers. Through a comprehensive analysis of keywords, we have identified "breast cancer" "pain" "anxiety" "lymphedema" "mastectomy" and "surgery" as central research themes within this domain, the corresponding clusters were subjected to analysis.
    Conclusion: This study provides a comprehensive review of breast cancer surgery research, emphasizing major research areas and proposing future research directions. This study provides a significant resource for researchers and clinicians in the field.
    Keywords:  bibliometric analysis; breast cancer surgery; international collaboration; publication patterns; research hotspots
    DOI:  https://doi.org/10.3389/fonc.2024.1508568
  18. Cureus. 2024 Dec;16(12): e76290
    Awake Craniotomy in Neurosurgery: A Bibliometric Analysis of the Top 100 Most-Cited Articles and Review of Technological Advancements.
    Billy McBenedict, Wilhelmina N Hauwanga, Yan Bin Fong, Anna Pogodina, Ebigbo E Obinna, Swetapadma Pradhan, Syeda Sukaina Kazmi, José Geraldo M Netto, Bruno Lima Pessôa.
      Awake craniotomy (AC) is a critical neurosurgical technique for maximizing tumor resection in eloquent brain regions while preserving essential neurological functions like speech and motor control. Despite its widespread adoption, no prior bibliometric analysis has evaluated the most influential research in this field. This study analyzed the top 100 most-cited articles on AC to identify key trends, influential works, and authorship demographics. A systematic search of the Web of Science Core Collection on September 17, 2024, yielded 718 publications, with the top 100 ranked by citation count. Analysis revealed a surge in AC research after 2013, peaking in 2021, with the Journal of Neurosurgery contributing significantly (49 articles; 2,611 citations). Themes included functional mapping, anesthetic techniques, and patient outcomes, with technological advancements such as intraoperative MRI and virtual reality enhancing surgical precision. Authorship analysis highlighted a gender disparity, with male authors occupying 77% of first authorship and 88% of senior roles. These findings underscore AC's evolution, foundational studies, and ongoing advancements while emphasizing the need for greater diversity and inclusion in the field.
    Keywords:  awake craniotomy; bibliometric analysis; eloquent brain regions; functional preservation; gender disparities in neurosurgery; glioma resection; intraoperative mapping; neuro-oncology; neurosurgical innovation; technological advancements
    DOI:  https://doi.org/10.7759/cureus.76290
  19. Quant Imaging Med Surg. 2025 Jan 02. 15(1): 813-830
    Evolutionary patterns and research frontiers of artificial intelligence in age-related macular degeneration: a bibliometric analysis.
    Zuyi Yang, Dianzhe Tian, Xinyu Zhao, Lei Zhang, Yiyao Xu, Xin Lu, Youxin Chen.
       Background: Age-related macular degeneration (AMD) represents a significant clinical concern, particularly in aging populations, and recent advancements in artificial intelligence (AI) have catalyzed substantial research interest in this domain. Despite the growing body of literature, there remains a need for a comprehensive, quantitative analysis to delineate key trends and emerging areas in the field of AI applications in AMD. This bibliometric analysis sought to systematically evaluate the landscape of AI-focused research on AMD to illuminate publication patterns, influential contributors, and focal research trends.
    Methods: Using the Web of Science Core Collection (WoSCC), a search was conducted to retrieve relevant publications from 1992 to 2023. This analysis involved an array of bibliometric indicators to map the evolution of AI research in AMD, assessing parameters such as publication volume, national/regional and institutional contributions, journal impact, author influence, and emerging research hotspots. Visualization tools, including Bibliometrix, CiteSpace and VOSviewer, were employed to generate comprehensive assessments of the data.
    Results: A total of 1,721 publications were identified, with the USA leading in publication output and the University of Melbourne as the most prolific institution. The journal Investigative Ophthalmology & Visual Science published the highest number of articles, and Schmidt-Eerfurth emerged as the most active author. Keyword and clustering analyses, along with citation burst detection, revealed three distinct research stages within the field from 1992 to 2023. Presently, research efforts are concentrated on developing deep learning (DL) models for AMD diagnosis and progression prediction. Prominent emerging themes include early detection, risk stratification, and treatment efficacy prediction. The integration of large language models (LLMs) and vision-language models (VLMs) for enhanced image processing also represents a novel research frontier.
    Conclusions: This bibliometric analysis provides a structured overview of prevailing research trends and emerging directions in AI applications for AMD. These findings furnish valuable insights to guide future research and foster collaborative advancements in this evolving field.
    Keywords:  Bibliometrics; age-related macular degeneration (AMD); artificial intelligence (AI); deep learning (DL)
    DOI:  https://doi.org/10.21037/qims-24-1406
  20. BMJ Open. 2025 Jan 22. 15(1): e094935
    Global vaccine research and application hotspots and trends: a systematic bibliometric analysis based on SCIE highly cited papers.
    Runfeng Shi, Huilin Cao, Meixin He, Yuyu Wang, Yue Zhu, Xinyu Wang, Caizhen You, Liming Liang, Xu Xia.
       OBJECTIVES: COVID-19, a public health emergency affecting the world in 2019, not only greatly promoted the development and application of vaccines but also effectively shortened the publishing time of scientific papers. In view of these facts, the current situation, status, problems and development trends of vaccine research and application were explored through bibliometric analysis of highly cited papers in the vaccine field within the time frame of 2014-2024, and the countries, institutions, authors, funding agencies and other relevant information that contributed most to vaccine research and application were summarised.
    DESIGN: Bibliometric analysis through data analysis and visual mapping.
    DATA SOURCES: Scientific articles.
    DATA EXTRACTION AND SYNTHESIS: 'Vaccine' and 'vaccines' were used in the WoS database to retrieve the publications and to adequately collect the data; Microsoft Excel was used for data analysis; and VOSviewer was used for visual description of data. Overall publication trends, countries, institutions and funding agencies, authors and articles, journals and languages, and research areas and co-occurrence keywords were analysed by bibliometrics.
    RESULTS: A total of 3258 highly cited papers were published in the field of vaccines in the past decade, from 735 different journals. With the COVID-19 pandemic in 2019, the number of highly cited papers in the field of vaccine research increased significantly from 2020 to 2024, accounting for 76.12%. The number of highly cited papers for vaccines peaked in 2021 and 2022, followed by a rapid decline. Highly cited papers came from 7133 institutions in 153 countries, and the most influential country in the field of vaccines was the USA, which published 1733 highly cited papers, accounting for 53.19% of the highly cited papers. The top 15 institutions with the largest influence were all from the USA or UK with 2567 published papers in total, accounting for 78.79% of highly cited papers. 4787 funding agencies were recognised in funding 2368 highly cited papers. A total of 30 926 authors in 90 research areas contributed significantly to global vaccine research. The most highly cited paper was 'Safety and Efficacy of the BNT162b2 mRNA COVID-19 Vaccine' from the New England Journal of Medicine, which was cited 9435 times in total. Among the 9848 co-occurrence keywords, COVID-19 (including SARS-CoV-2, 2019-COVID and SARS2) was the most frequently co-occurrence keyword. It appeared in 1720 articles, accounting for 52.79%, indicating that COVID-19 was the most popular study in the last decade.
    CONCLUSIONS: This study visualised the research and application of vaccines in the world from the perspective of papers output, drew the knowledge map and identified the important research hotspots and development trends in the vaccine field in the recent 10 years (2014-2024), which is helpful for Centres for Disease Control and Prevention, clinicians, researchers and health policymakers to better understand the research status and problems in vaccine research and application and predict its future development direction.
    Keywords:  BIOTECHNOLOGY & BIOINFORMATICS; COVID-19; Public health; Vaccination
    DOI:  https://doi.org/10.1136/bmjopen-2024-094935
  21. Emerg Med Int. 2025 ;2025 9975595
    Mapping Trends Regarding the Cardiopulmonary Resuscitation: A Bibliometric Analysis of the Top 100 Cited Articles.
    Ömer Faruk Turan, Ali Sami Yardımcı, Merve Yazla, Nurullah İshak Işık, Abdullah Osman Koçak, Burak Katipoğlu.
      Introduction: Despite significant medical and technological advancements, cardiac arrest remains a critical public health concern due to its persistently high mortality and morbidity rates. Consequently, research on cardiopulmonary resuscitation (CPR) is of significant importance. Materials and Methods: This study presents a bibliometric analysis of the 100 most-cited articles in the field of CPR identified using the Scopus database without time restrictions. Analyses were conducted using VOSviewer and Bibliometrix software. Original research articles published in English were included. Results: The study revealed contributions from 798 distinct authors across 18 journals, with citation counts ranging from 218 least-cited articles to 1194 most-cited articles. The most recent article was published in 2020, and the most frequently used keywords were "CPR" and "heart arrest." In addition, 20% of the analyzed articles were funded by military organizations. Conclusion: This analysis highlights the significant contributions of emergency medicine researchers and the notable development of CPR literature, particularly between the late 1990s and the early 2000s. While the most-cited studies originated from journals with high H-indices, the citation frequency of these articles showed a consistent decline over time. Furthermore, impactful articles in this field were predominantly published in general medical journals rather than in specialized emergency medicine journals. This study provides a foundational resource for researchers, especially early career academicians, seeking to engage in CPR-related research.
    Keywords:  Scopus; bibliometrics; cardiac arrest; cardiopulmonary resuscitation
    DOI:  https://doi.org/10.1155/emmi/9975595
  22. World J Psychiatry. 2025 Jan 19. 15(1): 100730
    Global research status and trends of somatic symptom disorder: A bibliometric study.
    Chao Yang, Kun Zhang, Qian Wang, Shuai Wang, Huan Li, Kai Zhang.
       BACKGROUND: With the growing scholarly and clinical fascination with somatic symptom disorder (SSD), a bibliometric analysis is lacking.
    AIM: To conduct a bibliometric analysis to investigate the current status and frontiers of SSD.
    METHODS: The documents related to SSD are obtained from the web of science core collection database (WoSCC), and VOSviewer 1.6.16 from January 1, 2000 to December 31, 2023, and the WoSCC's literature analysis wire were used to conduct the bibliometric analysis.
    RESULTS: A total of 567 documents related to SSD were included, and 2325 authors across 947 institutions from 57 countries/regions have contributed to SSD research, published in 277 journals. The most productive author, institution, country and journal were Löwe B, University of Hamburg, Germany, and Journal of Psychosomatic Research respectively. The first high-cited document was published in the Journal of Psychosomatic Research in 2013 by Dimsdale JE and colleagues, which explored the rationale behind the SSD diagnosis introduction in diagnostic and statistical manual of mental disorders.
    CONCLUSION: In conclusion, the main research hotspots and frontiers in the field of SSD are validity and reliability of the SSD criteria, functional impairment of SSD, and the treatment for SSD. More high-quality studies are needed to assess the diagnosis and treatment of SSD.
    Keywords:  Bibliometric analysis; Functional impairment; Somatic symptom disorder; Treatment; Validity and reliability
    DOI:  https://doi.org/10.5498/wjp.v15.i1.100730
  23. Front Microbiol. 2024 ;15 1514738
    Trends and advances in Leptospira, a bibliometric analysis.
    Wei Wang, Yamin Gao, Jianyu Ji, Zhai Huang, Bin Xiong, Shulin Xiang.
       Background: Leptospirosis is an acute zoonotic disease caused by pathogenic Leptospira, primarily transmitted to humans through contact with water or soil contaminated by the bacteria. It is globally distributed, with heightened prevalence in tropical regions. While prior studies have examined the pathophysiology, epidemiology, and risk factors of leptospirosis, few have explored trends and emerging topics in the field. This study applies bibliometric analysis to generate a visual knowledge map, identifying research hotspots and forecasting future trends in leptospirosis investigations.
    Methods: Data were extracted from the Web of Science Core Collection (WOSCC), encompassing all publications up to May 1, 2024. CiteSpace and VOSViewer software were used to analyze annual publication trends, as well as contributions from countries, institutions, journals, authors, references, and keywords, thereby pinpointing current research priorities and potential future directions.
    Results: A total of 5,244 articles were included, sourced from 4,716 institutions, 955 journals, and 156 countries or regions. The United States led with 1,315 publications and had the most significant influence in the field. "PLOS Neglected Tropical Diseases" published the highest number of articles (166), while "Infection and Immunity" garnered the most citations (6,591). Prominent research areas included restriction endonucleases, monoclonal antibodies, outer membrane proteins, water environments, detection methods, and antimicrobial agents. Research focus has shifted from early genomic and antigenic studies to investigations into outer membrane protein functions and environmental persistence, culminating in recent advances in molecular mechanisms and diagnostic technology development.
    Conclusion: This bibliometric analysis provides a comprehensive snapshot of leptospirosis research, emphasizing collaborations and impact among authors, countries, institutions, and journals. It offers valuable insights into ongoing trends and serves as a reference for future collaboration and research opportunities in the field.
    Keywords:  Leptospira; Web of Science Core Collection; bibliometric analysis; research hotspots; trends
    DOI:  https://doi.org/10.3389/fmicb.2024.1514738
  24. Neurosurg Rev. 2025 Jan 23. 48(1): 75
    Research progress of early brain Injury in subarachnoid hemorrhage from 2004 to 2024: a bibliometric analysis.
    Hongjiang Ye, Xin Wang, Wenxi Xie, Wenqiao Fu, Yidan Liang, Jiahe Tan, Yinrui Ma, Yin Tang, Daiqi Xu, Han Xiong, Yiming Zhuang, Zhaohui He.
      Early brain injury (EBI) after subarachnoid hemorrhage (SAH) is a clear correlation with poor prognosis. In the past 20 years, the research on EBI has increased rapidly. However, there is a lack of bibliometric analysis related to EBI. The purpose of this study was to identify emerging targets for the treatment of EBI and analyze the current situation and trend of EBI post-SAH in the past 20 years through bibliometric analysis. EBI related literature was retrieved from Web of Science Core Collection during 2004-2024, and analyzed by Microsoft Office Excel 2023, CiteSpace, and VOSviewer. 1364 articles were retrieved, and finally 1271 articles were involved in the analysis. The number of EBI-related articles has grown steadily over the past 20 years. China cooperated most closely with other countries. Loma Linda University was the most productive institution and John H Zhang was the most prolific author. The most productive and co-cited journals were Translational Stroke Research and Stroke, respectively. The burst keywords suggested that EBI research was focusing on cell inflammation and multiple mechanisms of cell damage. This is the first bibliometric analysis of EBI-related studies after SAH. As a critical period for the treatment of SAH, our study will provide a good direction for future investigators.
    Keywords:  Bibliometric analysis; CiteSpace; EBI; Early brain injury; Subarachnoid hemorrhage
    DOI:  https://doi.org/10.1007/s10143-025-03233-6
  25. Front Med (Lausanne). 2024 ;11 1445550
    Evolutionary patterns and research frontiers in autophagy in podocytopathies: a bibliometric analysis.
    Feng Liu, Ziyu Xu, Gaijie Chen, Xiaojing Xu, Huixia Cao, Jiefang Chen.
       Introduction: Podocytopathies are a uniquely renal disease syndrome, in which direct or indirect podocyte injury leads to proteinuria or nephrotic syndrome. Of the many factors that contribute to podocytopathies, the abnormal regulation of autophagy, such insufficient or excessive autophagy levels, have been proposed to play a significant role in the occurrence and development of podocytopathies. However, there still has been a lack of systematic and comparative research to elucidate exact role of autophagy in podocytopathies and its current research status. This study aims to utilize bibliometric analysis to clarify the role of autophagy in the pathogenesis of podocytopathies, analyze the research focus in this area, as well as explore the future research trends.
    Methods: We retrieved original articles and review papers with respect to autophagy in podocytopathies research published between the year 2008 and 2022 from the Web of Science Core Collection (WOSCC). Then, VOSviewer and CiteSpace software were employed to reveal the leading subjects and generate visual maps of countries/regions, organizations, authors, journals, and keyword networks in this field.
    Results and discussion: A total of 825 publications regarding autophagy in podocytopathies published between 2008 and 2022 were included, with China contributing the most followed by the United States and Japan. Professor Koya Daisuke, Professor He Qiang, and Professor Jin Juan are the most prolific researchers in this field. Oxidative stress, the NLRP3 inflammasome, and therapeutic targets were the knowledge base for the research in this special field. Taken together, this bibliometric analysis helps us reveal the current research hotspots and guide future research directions, which provides a reference for scholars to further investigate the role of autophagy in podocytopathies as well as conduct clinical trial with autophagy regulators in podocytopathies.
    Keywords:  Web of Science Core Collection; autophagy; bibliometric analysis; podocytopathies; visualization analysis
    DOI:  https://doi.org/10.3389/fmed.2024.1445550
  26. Nanomedicine (Lond). 2025 Jan 20. 1-12
    Global research trends on nanotechnology and colorectal cancer: a two-decade analysis.
    Xinyu Mao, Xinhao Li, Shiwei Liu, Hui Dong, Weilu Jia, Wenjing Xu, Xia Wu, Yewei Zhang.
       INTRODUCTION: Colorectal cancer (CRC) remains a serious threat to humans worldwide. In this study, we used bibliometric analysis of the scientific literature to assess the trends and prospects of nanotechnology applications in CRC.
    MATERIALS AND METHODS: We used the Web of Science Core Collection database to screen relevant publications on nanotechnology and CRC from 2004 to 2023 based on the inclusion criteria. Bibliometric analyses were performed on all selected publication and citation data. Visual analysis using VOSviewer and CiteSpace intuitively reflected the hotspots in this field.
    RESULTS: In total, 2040 publications on nanotechnology in CRC were identified for this two-decade analysis. China (443, 29.14%) and the USA (199, 13.09%) were the top two most productive countries, and Sichuan University was the most prolific institution. The most influential journal was the International Journal of Nanomedicine. The author with the most papers was Li L. "Nanoparticles," "drug delivery," and "CRC" were the most common keywords. Green synthesis and gold nanoparticles were peripheral, incompletely developed topics.
    CONCLUSION: This study provides a comprehensive overview of nanomaterials in CRC as clinical medicine, enriching the body of evidence in this field.
    Keywords:  Bibliometric; colorectal cancer; drug delivery; nanomedicine; nanotechnology
    DOI:  https://doi.org/10.1080/17435889.2025.2452833
  27. Heliyon. 2025 Jan 15. 11(1): e41258
    Research focus and theme evolution on enhanced external counterpulsation: A bibliometric analysis.
    Weimei Yang, Lijuan Lu, Jie Cheng, Xifei He.
       Aims: The study delved into the identification of key research areas and evolving trends within the domain of Enhanced External Counterpulsation, aiming to gain comprehensive insights into the subject matter.
    Methods: Utilizing the sophisticated search parameter of 'topic' (TS) on the Web of Science (WoS) database, the necessary information was retrieved. This research employed an array of tools for effective data extraction, analysis, and visualization, which included Microsoft Excel for tabular management, HistCite Pro for citation analysis, GunnMap for geographical mapping, BibExcel for bibliometric assessments, and VOSviewer for network visualization purposes.
    Results: From its establishment up until March 31, 2024 a total of 535 entries were recorded in the WoS database, with 491 of these relevant to the specified subject matter. The USA was the most prolific country, and China ranked second. Sun Yat Sen University was the most productive institution, which was from China. And 80 % of the top 10 institutions were from the USA. A keyword co-occurrence analysis was conducted, revealing four distinct research foci. And they were the application of EECP in cardiovascular disease, the main indications of EECP, the mechanism of EECP and the therapeutic effect of EECP, respectively. Researchers paid the most attention to the application of EECP on the cardiac cardiovascular system. Professor Lawson WE, Hui JCK and Kennard ED were the top three prolific authors. Lawson WE, Henry TD, Braith RW and Zheng ZS were identified as the core authors in the author co-citation network analysis.
    Conclusion: A comprehensive analysis was conducted on the literature surrounding improved enhanced external counterpulsation in this investigation, which can help researchers understand the theme trend better and grasp the research gap, to carry out further research and promote the progress of the topic.
    Keywords:  Bibliometric analysis; Cardiovascular disease(CVD); Citation network; Enhanced external counterpulsation(EECP); Research focus; Theme trends
    DOI:  https://doi.org/10.1016/j.heliyon.2024.e41258
  28. Front Oncol. 2024 ;14 1495911
    Research hotspots and trends in lung cancer STAS: a bibliometric and visualization analysis.
    Xiuhua Peng, Hupo Bian, Hongxing Zhao, Dan Jia, Mei Li, Wenhui Li, Pengliang Xu.
       Purpose: This study employed the R software bibliometrix and the visualization tools CiteSpace and VOSviewer to conduct a bibliometric analysis of literature on lung cancer spread through air spaces (STAS) published since 2015.
    Methods: On September 1, 2024, a computer-based search was performed in the Web of Science (WOS) Core Collection dataset for literature on lung cancer STAS published between January 1, 2015, and August 31, 2024. VOSviewer was used to visually analyze countries, institutions, authors, co-cited authors, and keywords, while CiteSpace was utilized to analyze institutional centrality, references, keyword bursts, and co-citation literature. Descriptive analysis tables were created using Excel 2021.
    Results: A total of 243 articles were included from the WOS, with a significant increase in annual publications observed since 2018. China, Kadota K, and Fudan University were leading countries, authors, and institutions by publication volume. The top three authors by co-citation count were Kadota K, Chen C, and Adusumilli PS. The journal with the highest publication volume was Lung Cancer, with the most influential journal among the top 10 being the Journal of Thoracic Oncology. The most frequently cited reference was "Lobectomy Is Associated with Better Outcomes than Sublobar Resection in Spread through Air Spaces (STAS)-Positive T1 Lung Adenocarcinoma: A Propensity Score-Matched Analysis." Keyword clustering categorized the research into four main areas: pathological studies of lung cancer STAS, biological mechanisms, prognostic assessment, and imaging analysis. Current research hotspots include deep learning, lung squamous cell carcinoma, and air spaces STAS.
    Conclusion: The current research on lung cancer STAS primarily focuses on pathological studies, biological mechanisms, prognostic assessments, and preoperative imaging model predictions. This study's findings provide new insights and directions for future research in this area.
    Systematic review registration: https://www.crd.york.ac.uk/prospero/#myprospero, identifier 589442.
    Keywords:  STAS; bibliometric analysis; deep learning; lung cancer; visualization analysis
    DOI:  https://doi.org/10.3389/fonc.2024.1495911
  29. Curr Vasc Pharmacol. 2025 Jan 17.
    Current Status and Future Trends in Myocarditis Related to the COVID-19 Vaccines: A Visual and Bibliometric Analysis.
    Youao Zhang, Mengjia Wang, Jieyan Wang.
       AIMS: This study aims to conduct a bibliometric and visual analysis of published studies on myocarditis and coronavirus disease 2019 (COVID-19) vaccines.
    BACKGROUND: The widespread epidemic of COVID-19 has caused millions of deaths and profoundly affected the global medical landscape. Studies on COVID-19 vaccination and related myocarditis have also increased significantly.
    OBJECTIVE: To analyze the current status and trends of myocarditis and COVID-19 vaccine research by bibliometric and to elucidate research hotspots and frontiers.
    METHODS: Based on the Web of Science Core Collection SCI-Expanded database, we utilize Excel 2019 and visualization analysis tools VOSviewer, Co-Occurrence13.2 (COOC13.2), Citespace, HistCite, and Scimago Graphica for analysis.
    RESULTS: Our study encompassed a total of 389 relevant articles, and we observed a consistent upward trend in the number of publications over time, indicating the growing interest in this subject. Among the countries and regions contributing to this body of literature, the United States emerged as the leading publisher, with Harvard Medical School being the most prominent institution associated with these studies. Notably, Matthew E. Oster from the United States emerged as one of the prominent authors in this field. Hotspot research and frontier areas include myocarditis and the different types of COVID-19 vaccines (e.g., mRNA vaccines, adenovirus vector vaccines, inactivated vaccines), the development of new vaccines in reducing the incidence and sequelae of COVID-19 without an increased incidence of myocarditis, and relief of vaccine hesitancy.
    CONCLUSION: Research on myocarditis and the COVID-19 vaccines has grown rapidly. Our research results can help researchers grasp the current status of myocarditis related to the COVID-19 vaccine research and find new research directions in the future.
    Keywords:  COVID-19 vaccines; bibliometrics.; frontiers; hotspots; myocarditis
    DOI:  https://doi.org/10.2174/0115701611287623250107074054
  30. Cureus. 2024 Dec;16(12): e76160
    Bibliometric Insights Into Thromboelastography Research Using PubMed and VOSviewer.
    Vamsi Krishna Uppalapati, Deb Sanjay Nag, Rishi Anand, Amlan Swain, Seelora Sahu, Himanshu Kumar.
      Thromboelastography (TEG) has evolved from a primarily surgical tool to a key instrument in broader medical fields, including personalized medicine for coagulopathies. The rationale for conducting this bibliometric analysis of TEG is to understand the evolution and current state of research in this critical field. By identifying publication trends, key contributors, and major developments, this study aims to provide valuable insights to guide future research and clinical practices in TEG. This bibliometric study, utilizing the PubMed database, delineates the research landscape of TEG by analyzing publication patterns, the frequency of keywords, and author collaborations to understand the growth and direction of the discipline. Bibliographic data were extracted from PubMed, encompassing publications up to the year 2024. Using VOSviewer software, network maps were generated to visualize relationships among authors, institutions, and thematic keywords. Rigorous selection criteria were applied, focusing on peer-reviewed articles relevant to TEG's medical and surgical applications, while excluding non-English papers, non-peer-reviewed materials, and non-clinical research. The analysis identified a significant increase in TEG-related publications in recent years: 461 in 2021, 427 in 2022, and 315 in 2023, with 6 publications early in 2024. Key figures such as Moore (111 publications), Nielsen (77 publications), and Moore (71 publications) emerged as prolific contributors. The research also highlighted a heightened focus on demographic-specific characteristics in TEG studies, reflecting the shift toward personalized medicine. This bibliometric analysis provides a comprehensive overview of TEG research, signifying its growing clinical relevance and potential for future applications. Despite limitations, such as potential database selection bias, the study outlines a clear expansion of TEG into various clinical environments and underscores the importance of inter-author collaboration. It suggests that TEG research is progressing towards interdisciplinary applications, including genetic profiling and machine learning, to further enhance patient-specific treatment modalities.
    Keywords:  bibliometric analysis; coagulopathies; personalized medicine; pubmed database; thromboelastography (teg); vosviewer
    DOI:  https://doi.org/10.7759/cureus.76160
  31. Behav Sci (Basel). 2025 Jan 20. pii: 99. [Epub ahead of print]15(1):
    It Is a Catch-22 Situation! A Decade of Research Trends on Gay Wellbeing in China: A Bibliometric Analysis.
    Jiankun Gong, Weishan Miao.
      The wellbeing of gay men in China is shaped by a combination of cultural, social, and political factors, yet research on this topic remains fragmented despite growing global interest in LGBTQ+ health. This study provides a comprehensive bibliometric analysis of research trends on wellbeing of gays (MSM) in China, using the PRISMA 2020 guidelines for a systematic search strategy and VOSviewer for bibliometric mapping. Data from Scopus were analyzed to examine publication output, top journals, and authors, along with a co-occurrence analysis of keywords and co-authorship networks across countries and authors. Results show a steady rise in publications over the past decade, particularly after 2015, revealing strong domestic collaboration and emerging international partnerships. The study identifies key contributing journals and themes, while revealing that most research remains narrowly focused on HIV/AIDS, leaving gaps in understanding gay wellbeing from broader societal and cultural perspectives. Surprisingly, very few studies specifically examine or measure overall wellbeing, whether using quantitative or qualitative approaches, and there is limited exploration of how cultural factors influence the experiences of gay men in China. These findings underscore the need for more holistic research approaches that move beyond public health and HIV prevention to address the psychological, social, and cultural dimensions of wellbeing.
    Keywords:  LGBTQ+ health; VOS viewer; bibliometric analysis; gay wellbeing; men who have sex with men (MSM) China; research trends
    DOI:  https://doi.org/10.3390/bs15010099
  32. Cureus. 2024 Dec;16(12): e75950
    Bibliometric Analysis of Research on Lip Prints.
    Rahul Krishna Rv, Sujitha Ponraj, Kavitha Ramar, Victor Samuel A, Rajakumar S, Anitha Annadurai, Arya Acca Varghese.
      Lip prints, or cheiloscopy, are unique patterns of grooves and wrinkles, gaining prominence in forensic science as reliable tools for personal identification, akin to fingerprints and DNA profiling. Advances in imaging techniques have enhanced their forensic applicability. This study conducts a bibliometric analysis to explore global research trends, key contributors, and thematic developments in lip print research. The search was done with a range of databases like Web of Science, Scopus, and PubMed in September 2024. Included were pertinent studies on lip print analysis, and studies that were irrelevant were excluded. Specific study characteristics, citations, and years of research publication were studied using VOSviewer (Centre for Science and Technology Studies, Leiden University, The Netherlands) and Biblioshiny (RStudio (Posit PBC, Boston, MA, US)) to examine various networks and themes of identity. Among the 5,864 articles retrieved, 198 studies were chosen for a detailed bibliometric analysis. The volume of research output has been on the rise since 1971. India leads with 133 publications backed by Saveetha University and Ajman University. Terms like "forensic identification" or "cheiloscopy" show an interest in the area of humans as an object of study. Collaborative networks are still unevenly developed and only begin to have international partnerships. This leading role of India is indicative of the importance Indian researchers are placing on forensic odontology as evidenced by the existence of regional journals and strong institutions. Foundational studies are still relevant today, though their frequency of citation per article has been decreasing as the discipline progresses. This bibliometric analysis presents the changes that have taken place over time in the field of lip print study and a particular focus on the input and collaboration of different regions of the world. Although some limitations have been noted, these results have implications in the development of forensic odontology as well as in the direction of equitable research development across the globe.
    Keywords:  bibliometric analysis; cheiloscopy; forensic identification; forensic odontology; lip print analysis
    DOI:  https://doi.org/10.7759/cureus.75950
  33. Quant Imaging Med Surg. 2025 Jan 02. 15(1): 852-866
    Bibliometric analysis of research on the application of deep learning to ophthalmology.
    Min Zhao, Haoxin Guo, Xindan Cao, Junshi Dai, Zhongqing Wang, Jiangyue Zhao, Cheng Peng.
       Background: Recently, deep learning has become a popular area of research, and has revolutionized the diagnosis and prediction of ocular diseases, especially fundus diseases. This study aimed to conduct a bibliometric analysis of deep learning in the field of ophthalmology to describe international research trends and examine the current research directions.
    Methods: This cross-sectional bibliometric analysis examined the development of research on deep learning in the field of ophthalmology and its sub-topics from 2015 to 2024. Visualization of similarities (VOS)-viewer was used to analyze and evaluate 3,055 articles. Data from the articles were collected on a specific date (September 11, 2024) and downloaded from the Web of Science Core Collection (WOSCC) in plain-text format.
    Results: A total of 3,055 relevant articles on the WOSCC published from 2015 to 2024 were included in this analysis. The first article on the application of deep learning to ophthalmology was published in 2015, and the number of articles on the subject has grown significantly since 2019. China was the most productive country (n=1,187), followed by the United States (n=673). Sun Yat-sen University was the institution with the most publications. Cheng and Bogunovic were the most frequently published authors. The following four different clusters were identified based on a co-occurrence cluster analysis of high-frequency keywords: (I) deep learning for the segmentation and feature extraction of ophthalmic images; (II) deep learning for the automatic detection and classification of ophthalmic images; (III) application of deep learning to ophthalmic imaging techniques; and (IV) deep learning for the diagnosis and management of ophthalmic diseases.
    Conclusions: The analysis of fundus images and the clinical application of deep learning techniques have emerged as prominent research areas in the field of ophthalmology. The substantial increase in publications and citations signifies the expanding impact and global collaboration in the application of deep learning research to ophthalmology. By identifying four distinct clusters representing sub-topics in deep learning ophthalmology research, this study contributes to the understanding of current trends and potential future advancements in the field.
    Keywords:  Deep learning; bibliometrics; convolutional neural networks (CNNs); fundus images; optical coherence tomography (OCT)
    DOI:  https://doi.org/10.21037/qims-24-1340
  34. Jpn J Nurs Sci. 2025 Jan;22(1): e12640
    Knowledge development of empowerment in nursing research: A bibliometric analysis using reference publication year spectroscopy.
    Hande Yesilbas, Filiz Kantek, Tangul Aytur Ozen.
       AIM: This bibliometric study aims to provide a comprehensive analysis of the history of empowerment in nursing using Reference Publication Year Spectroscopy (RPYS).
    METHODS: Descriptive and bibliometric analyses were conducted. The study is based on 762 publications from 1983 to 2024, with 14,582 cited references in the Web of Science. The reference publication period was divided into three sub-periods, with a total of 17 peaks identified: four from the first period (earliest to 1980), six from the second (1981-2000), and seven from the last period (2001-2024). Data analysis was performed using RPYS with the CRExplorer.
    RESULTS: Ten significant historical root publications, dating back to 1859, were identified, focusing on leadership, professionalism, social psychology, and philosophy of education. The earliest roots are linked to Florence Nightingale. In the recent period, there was a greater number of nursing-based root publications cited.
    CONCLUSION: This study is the first to identify the origins of influential nursing empowerment publications using RPYS. The earliest publications referenced in nursing empowerment literature originate from nursing. The RPYS proved to be a valuable approach for analyzing the historical roots of knowledge in nursing empowerment.
    Keywords:  cited‐reference analysis; data visualization; empowerment; historical roots; nursing; reference publication year spectroscopy
    DOI:  https://doi.org/10.1111/jjns.12640
  35. Front Pharmacol. 2024 ;15 1488340
    Research hotspots and frontiers of endoplasmic reticulum in glomerular podocytes: a bibliometric and visual analysis from 2005 to 2023.
    Wang Junli, Hao Zhihong, Wang Lina, Ou Qiaoqun, Qu Jing, Hu Jiaqi, Shengyou Yu.
       Background: The glomerular podocyte endoplasmic reticulum is a critical component in renal function, yet its research landscape is not fully understood. This study aims to map the existing research on podocyte endoplasmic reticulum by analyzing publications in the Web of Science Core Collection (WOSCC) from the past 19 years.
    Methods: We conducted a bibliometric analysis using Citespace, VOSviewer, the Metrology Literature Online platform, and the Bibliometrix software package to visualize and interpret the data from WOSCC. The analysis focused on publication volume, authorship, institutional contributions, and research trends.
    Results: The analysis revealed a significant growth in publications, indicating a surge in interest in podocyte endoplasmic reticulum research. Cybulsky, Andrey V, and Papillon, Joan emerge as the most prolific authors, and the Journal of the American Society of Nephrology is the leading journal in this field. China is the top contributor in terms of publications, with McGill University being the most productive institution. The research primarily focuses on endoplasmic reticulum stress, diabetic nephropathy, and apoptosis, with emerging trends in "foot cell apoptosis," "cell signaling pathways," and "autophagy."
    Conclusion: The findings highlight the expanding scope of podocyte endoplasmic reticulum research, with a particular emphasis on the mechanisms of endoplasmic reticulum stress and podocyte apoptosis. Future research directions may include the identification of specific therapeutic targets, detailed exploration of podocyte signaling pathways, and the role of autophagy. This study provides a comprehensive overview of the major research areas, frontiers, and trends in podocyte endoplasmic reticulum research, which are pivotal for guiding future investigations.
    Keywords:  bibliometric analysis; endoplasmic reticulum; endoplasmic reticulum stress; glomerular podocyte; research hotspots
    DOI:  https://doi.org/10.3389/fphar.2024.1488340
  36. World J Gastrointest Endosc. 2025 Jan 16. 17(1): 100219
    Bibliometric analysis on the top one hundred cited studies on gastrointestinal endoscopy.
    Jing Sui, Jian-Sheng Luo, Chao Xiong, Chun-Yong Tang, Yan-Hua Peng, Rui Zhou.
       BACKGROUND: Gastrointestinal endoscopy has been widely used in the diagnosis and treatment of gastrointestinal diseases. A great many of studies on gastrointestinal endoscopy have been done.
    AIM: To analyze the characteristics of top 100 cited articles on gastrointestinal endoscopy.
    METHODS: A bibliometric analysis was conducted. The publications and their features were extracted from the Web of Science Core Collection, Science Citation Index-Expanded database. Excel, Web of Science database and SPSS software were used to perform the statistical description and analysis. VOSviewer software and MapChart were responsible for the visualizations.
    RESULTS: The top 100 cited articles were published between 1976 and 2022. The guidelines (52%) and clinical trials (37%) are the main article types, and average publication year of the guidelines is much later than that of the clinical trials (2015 vs 1998). Among the clinical trials, diagnostic study (27.0%), cohort study (21.6%), case series (13.5%) and cross-sectional study (10.8%) account for a large proportion. Average citations of different study types and designs of the enrolled studies are of no significant differences. Most of the 100 articles were published by European authors and recorded by the endoscopic journals (65%). Top journals in medicine, such as the Lancet, New England Journal of Medicine and JAMA, also reported studies in this field. The hot spots of involved diseases include neoplasm or cancer-related diseases, inflammatory diseases, obstructive diseases, gastrointestinal hemorrhage and ulcer. Endoscopic surgery, endoscopic therapy and stent placement are frequently studied.
    CONCLUSION: Our research contributes to delineating the field and identifying the characteristics of the most highly cited articles. It is noteworthy that there is a significantly smaller number of clinical trials included compared to guidelines, indicating potential areas for future high-quality clinical trials.
    Keywords:  Bibliometric analysis; Clinical trial; Gastrointestinal endoscopy; Guideline; Quality of study
    DOI:  https://doi.org/10.4253/wjge.v17.i1.100219
  37. Transl Lung Cancer Res. 2024 Dec 31. 13(12): 3764-3777
    Mapping the evolution and frontiers of Translational Lung Cancer Research: a bibliometric analysis and literature review.
    Chong Li, Anqi He, Jing Hu, Yong Xia, Chengqi He, Weihua Zhuang.
       Background and Objective: While bibliometric studies of single journals have been conducted, bibliometric mapping has not yet been used to analyze the literature published by the Translational Lung Cancer Research (TLCR). This study aimed to comprehensively review all publications of TLCR from its inception to 2024 and provide a detailed overview of its main publication characteristics.
    Methods: This study analyzed publications from TLCR spanning 2012 to 2024 using CiteSpace, VOSviewer, and the 'Bibliometrix' package in R. Descriptive bibliometric methods were employed to examine the trends and dynamics in TLCR literature, identifying leading authors, institutions, and countries in terms of publication output. Furthermore, bibliometric maps were generated to visualize key research topics and terms, highlighting their evolution over time.
    Key Content and Findings: The analysis included 2,032 publications in TLCR from 2012 to 2023 and 121 publications in 2024. The study revealed a positive trend in literature production, although there has been a slight recent decline in the number of articles published in the TLCR. China emerged as the most productive country (n=587), with Shanghai Jiao Tong University being the most productive institution (n=127). Jianxing He from the First Affiliated Hospital of Guangzhou Medical University was identified as the most prolific author (n=75). The top ten most cited articles primarily address treatment strategies, recurrence, immune-related toxicities, global trends in mortality, and mechanisms of resistance, reflecting the broad scope and critical importance of ongoing research in lung cancer. Research published in TLCR predominantly targeted old adults with non-small cell lung cancer (n=879), with significant emphasis on overall survival (n=507), cancer staging (n=406), and cancer immunotherapy.
    Conclusions: This study reviewed TLCR publications from 2012 to 2024, identifying key trends, top contributors, and research focuses. Future research directions in TLCR might focus on first-line treatment, ensartinib, and advanced data analysis methods such as the Kyoto Encyclopedia of Genes and Genomes (KEGG) to revolutionize lung cancer research and practice. In conclusion, this study underscores TLCR's significant contributions to lung cancer research and provides valuable insights into its evolution and future directions.
    Keywords:  Bibliometrix; CiteSpace; Translational Lung Cancer Research (TLCR); VOSviewer; bibliometric
    DOI:  https://doi.org/10.21037/tlcr-24-653
  38. Front Pharmacol. 2024 ;15 1477633
    Current research status and trends of potassium-competitive acid blockers in the treatment of acid-related diseases: a bibliometric analysis.
    Baoqiang Zhu, Long Chen, Xue Tao, Hong Zheng, Xia Li, Qingfang Wu, Enwu Long, Haixia Lin.
       Objective: To explore the current research status and trends of potassium-competitive acid blockers (P-CABs) in the treatment of acid related diseases (ARDs) using bibliometric analysis.
    Materials and methods: We collected publications related to P-CAB in the treatment of acid-related diseases in the Web of Science (WOS) Core Collection from the establishment of the database to 30 June 2024. We evaluated the publication volume and citation status over the years using the WOS platform, and visualized the authors, countries, institutions, keywords, and citations of the publications using CiteSpace and VOSviewer.
    Results: This study included a total of 455 articles. The number of publications and citations related to research has been increasing year by year. The results show that the scholars with the highest number of publications mainly come from South Korea and Japan. Scholars such as Geun Seog Song, Bongtae Kim, and Nobuhiro Inatomi produced many works in related fields. The most popular drug in this field was vonoprazan, and research on this drug mainly focused on the effectiveness and safety evaluation of ARDs such as Helicobacter pylori infection, gastroesophageal reflux disease, peptic ulcers, etc. Researchers were concerned about the evaluation of treatment regimens and efficacy comparison between P-CABs and traditional proton pump inhibitors (PPIs) in the treatment of ARDs. At the same time, researchers are also closely monitoring the potential adverse reactions and long-term adverse outcomes of clinical application of P-CABs for ARDs.
    Conclusion: The clinical application of P-CABs, represented by vonoprazan, in ARDs is receiving widespread attention from researchers. The exploration of the application of this type of drug in ARDs is constantly expanding, and it is a research field with great clinical value and research potential.
    Keywords:  CiteSpace; VOSviewer; acid-related diseases; bibliometric; potassium-competitive acid blocker
    DOI:  https://doi.org/10.3389/fphar.2024.1477633
  39. J Arthropod Borne Dis. 2024 Jun;18(2): 84-93
    Global Trends in Studies on the Presence of Demodex spp. in Patients Diagnosed with Blepharitis.
    Rahmi Yildiz, Milad Afşar, Sadi Elasan.
       Background: The main objective of this study is to review publications on the presence of Demodex spp. in patients diagnosed with blepharitis worldwide and to analyse the trends and groups in this field.
    Methods: This bibliometric study was conducted to detect the presence of Demodex spp. in patients diagnosed with blepharitis worldwide between 1984 and 2023. For this purpose, 288 studies were examined as a result of searches using the keywords "Blepharitis and Demodex" in Web of Science (WOS) databases. All text data was analysed using VOSviewer software to ensure accuracy and reliability. In this study, analysis using text mining and data visualization techniques (bubble maps and graphs) helped to make the results more understandable.
    Results: This study provided information on 288 articles from WOS databases. The average total number of citations is 1305 and the H-index is 41. The majority of articles (63%) were published in the field of ophthalmology. The countries that published the most articles on this topic were the USA (24%), China (13%), and Turkey (11%).
    Conclusion: This study is the first bibliometric study of patients diagnosed with blepharitis due to Demodex spp. The most used keyword in blepharitis is Demodex. The most studied field of research is ophthalmology and the most studied country is the United States of America. The results of this bibliometric analysis conducted by us reveal global trends in the presence of Demodex spp. in patients diagnosed with blepharitis and provide important information for future directions of research.
    Keywords:  Bibliometric analysis; Blepharitis; Demodex
    DOI:  https://doi.org/10.18502/jad.v18i2.17531
  40. J Educ Health Promot. 2024 ;13 489
    Bibliometric analysis of teen pregnancy research in Asia-Africa: Explore the future scope.
    Esti Nugraheny, Bunga A Paramashanti, Eny R Ambarwati, Yanti Yanti, Ocktariyana Ocktariyana, Tri Sunarsih, Zulvi Wiyanti, Hadi Ashar.
       BACKGROUND: Adolescent pregnancy is prevalent in Asian-African countries. Hence, it is critical to track the progress of research and development trends related to the topic. The study aimed to characterize published articles on teen pregnancy by measuring the authors' country and affiliation, most relevant and cited journals, thematic research, and growth trends.
    MATERIALS AND METHODS: Descriptive statistics and retrospective bibliometric analysis were used. Using the Scopus database, we collected published articles from 2010 to 2023. Titles and abstracts were screened. Eligible papers were reviewed based on co-occurrence analysis. Classification and visualization of results were conducted using VOSviewer software version 1.6.17.
    RESULTS: A total of 369 articles were relevant and included in the review. The countries that produced the most publications were South Africa and the United States. The most relevant affiliation was with the University of Cape Town, the University of the Witwatersrand, and the University of Kwazulu-Natal. The most relevant source journals were PLOS One, Reproductive Health, and BMC Public Health. The most cited sources were Lancet, PLOS One, and AIDS Journal. Four clusters were obtained that reflect the main topics, including human immunodeficiency virus (HIV) infection, child, health services, and pregnancy. The current research terms include HIV infection and maternal health services.
    CONCLUSIONS: This study suggests more research on the term "vertical transmission, breastfeeding, and partner violence" related to teen pregnancy. In addition, this research will inspire researchers and adolescent health policymakers to expand the scope of research to solve teenage pregnancy problems based on interdisciplinary theories and methods.
    Keywords:  Adolescent health services; Africa; Asia; bibliometric analysis; teen pregnancy
    DOI:  https://doi.org/10.4103/jehp.jehp_351_24
  41. J Relig Health. 2025 Jan 18.
    Teaching Spirituality in Nursing: A Bibliometric Analysis.
    Ana Afonso, Sara Sitefane, Janaína Fabri, Isabel Rabiais, Sílvia Caldeira.
      The study of spirituality in nursing education has become an emerging academic field, making it important to understand its evolution using bibliometric indicators. To achieve this, a search was conducted on July 8, 2024, using the Web of Science and Scopus databases. Titles and abstracts were screened in Rayyan, and data analysis was performed using Bibliometrix and Biblioshiny in the R language. A total of two hundred thirty documents published between 1981 and 2024 were included. The United States contributed the most publications (n = 70), and Wilfred McSherry was the most prolific author, with 16 publications and the highest h-index. Nurse Education Today was the journal with the most publications. Transition themes identified include spiritual competence and spiritual care education.
    Keywords:  Bibliometrics; Education; Nurse; Spiritual care; Teaching
    DOI:  https://doi.org/10.1007/s10943-024-02247-6
  42. Genes Chromosomes Cancer. 2025 Jan;64(1): e70019
    A Bibliometric Analysis on the Risk Factors of Cancer.
    Shan Chen, Yuanzhao Ding.
      Given the high lethality of cancer, identifying its risk factors is crucial in both epidemiology and cancer research. This study employs a novel bibliometric analysis method, which uses the tidytext package and tidy tools in R. This approach surpasses traditional tools like VOSviewer, offering more comprehensive and complex keyword data and clearer results compared to Bibliometrix. By using R, researchers can efficiently handle useful keywords, ignore irrelevant terms, adjust specific settings, and correct errors such as repeated evaluations. This study examines 1000 articles sourced from the Web of Science database, using advanced bibliometric tools like R Studio to analyze publication quantity, frequency, and word co-occurrences. The primary goal is to uncover key risk factors associated with cancer and explore the underlying mechanisms that link these factors to cancer development. Risk factors are categorized into exogenous (environmental exposures and lifestyle choices) and endogenous (genetic predispositions and hormonal imbalances). By providing a comprehensive analysis of these factors, the study aims to deepen our understanding of cancer risk. This research contributes valuable insights to the broader field of cancer research and has the potential to inform future studies and strategies for cancer prevention and treatment.
    Keywords:  R studio; bibliometric analysis; cancer research; web of science
    DOI:  https://doi.org/10.1002/gcc.70019
  43. Curr Probl Cardiol. 2025 Jan 17. pii: S0146-2806(25)00007-6. [Epub ahead of print]50(3): 102984
    Cardiac surgery outcomes: The efficacy of dexmedetomidine in reducing postoperative delirium - A bibliometric study.
    Wang Yabo, Li Dongxu, Li Xiao, An Qi.
      Postoperative delirium (POD) is a prevalent complication following cardiac surgery, characterized by acute brain dysfunction observed in critically ill patients. Despite the significant impact of POD, there is currently no established treatment. Recent research has suggested that modulation of cholinergic neurotransmission and α2-adrenergic receptors may offer a therapeutic strategy for managing delirium during critical illness. This study employs bibliometric analysis to examine the emerging evidence on the role of dexmedetomidine, an α2-receptor agonist drug, in the prevention and treatment of POD. A systematic bibliometric analysis was conducted to identify and evaluate the literature on the use of dexmedetomidine in relation to POD. The study period spanned from 2006 to 2022, and the search was conducted in the Web of Science (WOS) database, focusing on relevant references. The analysis included the examination of the most frequent keywords, research trends, and frontiers to provide a comprehensive overview of the field. The bibliometric analysis revealed 160 research papers on the topic, indicating a significant increase in research output over the past decades. The field distribution, knowledge structure, and research topic evolution were identified as key areas of exploration. The analysis also highlighted the emergence of new topics and trends in the study of POD and its management. This bibliometric analysis provides a robust framework for understanding the current state of research on dexmedetomidine's efficacy in managing POD. It highlights the need for continued investigation and underscores the potential of this pharmacological approach to improve patient outcomes following cardiac surgery.
    Keywords:  Cardiac surgery; Cite space analysis; Dexmedetomidine; Postoperative delirium; Visualized analysis; α2-adrenoceptor
    DOI:  https://doi.org/10.1016/j.cpcardiol.2025.102984
  44. Discov Oncol. 2025 Jan 22. 16(1): 79
    Bibliometric and visual analysis of chronic stress in cancer research from 2014 to 2024.
    Zhuheng Wei, Anxia Li, Ling Su, Bo Zhang, Yuanyuan Yan.
       OBJECTIVE: In today's fast-paced society, stress has become a widespread phenomenon, garnering increasing attention for its impact on cancer. This study aims to investigate the current status and research hotspots of chronic stress in cancer research from 2014 to 2024, with the goal of providing valuable insights for future studies.
    METHODS: We retrieved 618 articles published between 2014 and 2024 from the Web of Science database and analyzed them using R software, VOSviewer, and CiteSpace.
    RESULTS: There is an overall upward trend in chronic stress-related cancer research, with China leading in publications, followed by the United States, India, Australia, and Italy. The journal most cited is Brain Behavior and Immunity. Key themes identified include 'inflammation', 'breast cancer', 'anxiety', 'psychological stress', and 'oxidative stress'. The primary focus of the research is the impact of chronic stress on various cancer types, the underlying molecular mechanisms, and the implications of chronic stress-related treatments on cancer outcomes.
    CONCLUSION: Chronic stress is increasingly recognized as a Carcinogenic factors. This study provides a comprehensive analysis of chronic stress-related cancer research from 2014 to 2024, offering valuable guidance for future research in this field.
    Keywords:  Bibliometric; Cancer; Endocrine; Immune system; Psycho-oncology chronic stress
    DOI:  https://doi.org/10.1007/s12672-025-01744-8
  45. Front Microbiol. 2024 ;15 1413490
    Gut microbiota and inflammasome-mediated pyroptosis: a bibliometric analysis from 2014 to 2023.
    Hang Zhang, Tian Zhao, Juan Gu, Fushan Tang, Lei Zhu.
       Background: The role of gut microbiota in inflammatory disease development and progression has been recognized more recently. Inflammasome-mediated pyroptosis in involved in these diseases. This complex relationship between gut microbiota and inflammasome-mediated pyroptosis provides an important field of research. Bibliometric analysis provides a comprehensive understanding of this relationship, offering valuable insights into emerging research trends.
    Materials and methods: Leveraging data spanning from 2014 to 2023 sourced from the Web of Science Core Collection, our analysis was conducted using advanced tools such as SCImago Graphica, VOSviewer, and CiteSpace software. Visualizations were created using GraphPad Prism software. We explored the nuanced aspects of research hotspots, collaborative networks, and developing trends in this field.
    Results: A global bibliometric analysis identified 520 relevant studies spanning 41 countries and 887 institutions. Over the past decade, publication trends have shown consistent growth, with China and the United States leading the research output. Southern Medical University and Nanjing Medical University in China emerged as leading institutions in this filed. Prominent contributors include Jia Sun, Yuan Zhang, Wei Chen, Jing Wang, and Hongtao Liu from China, alongside Eicke Latz from Germany. High-impact journals such as Frontiers in Immunology and Nature Communications have been pivotal in disseminating research in this domain. Keyword analysis highlighted a primary focus on gut microbiota, NLRP3 inflammasome, pyroptosis pathways, and inflammatory diseases, themes that persist in recent studies. Furthermore, burst keyword analysis identified "butyrate" as the sole term currently experiencing a marked increase in research interest.
    Conclusion: Research has been deeply focused on the gut microbiota and inflammasome triggered pyroptosis in years. Over the past decade, the exploration of how gut microbiota and NLRP3 or NLRP6 inflammasome-mediated pyroptosis has been an area of interest. Future investigations in this filed may primarily revolve around understanding the correlation between butyrate and NLRP3 inflammasome induced pyroptosis in relation to conditions. However, an in-depth analysis, through studies is crucial to uncover and elucidate the complex mechanisms linking these elements.
    Keywords:  bibliometrics; butyrate; gut microbiota; inflammasome; inflammatory diseases; pyroptosis
    DOI:  https://doi.org/10.3389/fmicb.2024.1413490
  46. Malays J Med Sci. 2024 Dec;31(6): 103-111
    Global Research Trends in Cervical Cancer Survival in the Last Two Decades: A Bibliometric Analysis.
    Syed S Abrar, Suhaily Mohd Hairon, Najib Majdi Yaacob, Mohd Pazudin Ismail, Seoparjoo Azmel Mohd Isa.
      Cervical cancer poses a significant challenge to global health, particularly in low- and middle-income countries. Tracking the survival rates of cancer patients through data gathered by population-based cancer registries constitutes a crucial aspect of cancer management. In recent years, attention within bibliometric studies has been directed towards examining the correlation between inflammation and radiotherapy in cervical cancer. However, to date, there is no published literature investigating research trends in cervical cancer survival through bibliometric analysis. Thus, this study was undertaken to identify and analyse global research patterns and hotpots in this area. A systematic search was performed within the Web of Science Core Collection (WoSCC) database, employing the following search parameters: TITLE - (((survival) OR (survival rate) OR (survival analysis) OR (survival probability)) AND ((cervical cancer) OR (cervical carcinoma))). A comprehensive analysis of research trends was conducted utilising various tools on the WoSCC website and VOSviewer. A total of 840 papers pertaining to cervical cancer and survival were identified from 45 distinct departments or subjects. Notably, the People's Republic of China and the USA collectively accounted for half of all publications from 2000 to 2023. An extensive cohort comprising 4,759 authors affiliated with 1,454 institutions across 82 countries contributed to the progression of this research domain. Despite a substantial increase in research on cervical cancer survival over the last decade, it is essential to encourage and conduct research, particularly in high-risk regions, especially in countries classified as low- or middle-income.
    Keywords:  VOSviewer; bibliometric; cervical cancer; survival
    DOI:  https://doi.org/10.21315/mjms2024.31.6.8
  47. Front Med (Lausanne). 2024 ;11 1451371
    Metabolic response to burn injury: a comprehensive bibliometric study.
    Yixu Li, Yifan Liu, Sujie Xie, Yushu Zhu, Xinran Ding, Wei Zhang, Shuyuan Xian, Guosheng Wu, Hanlin Sun, Jiale Yan, Bingnan Lu, Yuntao Yao, Weijin Qian, Yuwei Lu, Yiting Yang, Dayuan Xu, Runzhi Huang, Shizhao Ji.
       Objective: Burns lead to systemic changes manifested by systemic disturbances in water-electrolyte balance and systemic metabolic and inflammatory responses. The hypermetabolic response after a burn injury relies on metabolic, hormonal, and inflammatory dysregulation mechanisms. This study aimed to provide a comprehensive bibliometric analysis of the burn metabolism research field, identifying key trends, influential contributors, and emerging research hotspots to inform future investigative efforts. Ultimately, we conducted an extensive review of the literature, synthesizing the findings to clarify the present understanding within our field of study.
    Methods: We obtained 8,823 scientific publications on burn injury and metabolism from the core Web of Science (WOS) database collection. In this work, biblioshiny was used to visualize and analyze the data, and VOSviewer was used to verify the results.
    Results: From a total of 8,823 publications, we found a general upward trend in annual publications and citation frequency. According to Bradford's Law, 21 high-production journals were classified as core sources based on the number of publications, and the most productive journal was Burns. The most published countries and authors in this field were the United States and Herndon DN. The most local cited document in this field was the article titled "Catecholamines: Mediator of the Hypermetabolic Response to Thermal Injury" authored by Wilmore DW. The thematic map showed that studies on injury, thermal injury, and sepsis were relatively mature. In contrast, research on metabolism, stress, and responses, and research on mortality, resistance, and management were less well-developed but were essential for the field.
    Conclusion: Research on burns and metabolism is increasing. Based on the bibliometric analysis, our study summarized the complex interplay between burn-induced systemic metabolic alterations and inflammatory responses, emphasizing the significance of hypermetabolism and its management. The role of propranolol, insulin, oxandrolone, and nutritional interventions in modulating the hypermetabolic state was discussed. Additionally, our study underscored the challenges of managing sepsis and drug-resistant infections in burn patients as an important future area of research.
    Keywords:  burn injury; inflammatory; management; metabolism; thermal injury
    DOI:  https://doi.org/10.3389/fmed.2024.1451371
  48. World J Psychiatry. 2025 Jan 19. 15(1): 100685
    Comprehensive bibliometric analysis of pharmacotherapy for bipolar disorders: Present trends and future directions.
    Bo-Fan Chen, Li Liu, Fang-Zhen Lin, Hai-Min Zeng, Hai-Qiang Huang, Chun-Fang Zhang, Cong-Cong Liu, Xiang Chen, Jie Peng, Yun-Fa Wang, Zhi-Lin Wang, Bin Chen, De-Le Liu, Yun Liu, Zheng-Zheng Li, Xin-Xing Zeng.
       BACKGROUND: Bipolar disorder (BD) is a severe mental illness characterized by significant mood swings. Effective drug treatment modalities are crucial for managing BD.
    AIM: To analyze the current status and future trends of global research on BD drug treatment over the last decade.
    METHODS: The Web of Science Core Collection database spanning from 2015 to 2024 was utilized to retrieve literature related to BD drug treatment. A total of 2624 articles were extracted. Data visualization and analysis were conducted using CiteSpace, VOSviewer, Pajek, Scimago Graphica, and R-studio bibliometrix to identify research hotspots, key contributors, and future trends.
    RESULTS: The United States, China, and the United Kingdom have made the most significant contributions to research on BD drug treatment and formed notable research collaboration networks. The University of Pittsburgh, Massachusetts General Hospital, and the University of Michigan have been identified as the major research institutions in this field. The Journal of Affective Disorders is the most influential journal. A keyword analysis revealed research hotspots related to clinical symptoms, drug efficacy, and genetic mechanisms. A citation analysis identified the management guidelines published by Yatham et al in 2018 as the most cited paper.
    CONCLUSION: This study provides a detailed overview of the field of BD drug treatment, highlighting key contributors, research hotspots, and future directions. The study findings can be employed as a reference for future research and policymaking, which may enable further development and optimization of BD pharmacotherapy.
    Keywords:  Bibliometric analysis; Bipolar disorder; Drug treatment; Mental disorder; Visualization
    DOI:  https://doi.org/10.5498/wjp.v15.i1.100685
  49. Front Immunol. 2024 ;15 1526481
    Bibliometric analysis of metformin as an immunomodulator (2013-2024).
    Tongyi Zhou, Yunfeng Yu, Liu Li, Xiu Liu, Qin Xiang, Rong Yu.
       Background: Metformin, the frontline treatment for diabetes, has considerable potential as an immunomodulator; however, detailed bibliometric analyses on this subject are limited.
    Methods: This study extracted 640 relevant articles from the Web of Science (WOS) Core Collection and conducted visual analyses using Microsoft Excel, VOSviewer, and CiteSpace.
    Results: The findings showed that research on the immunomodulatory function of metformin has grown steadily since 2017, with China and the United States being the leading contributors. These studies have mostly been published in journals such as the International Journal of Molecular Sciences, Cancers, Frontiers in Immunology, and Scientific Reports. Keyword co-occurrence analysis highlighted metformin's role as an immunomodulator, particularly in the context of the tumor immune microenvironment, immunosuppressive checkpoints, and metformin derivatives. Recent research has highlighted metformin's application in aging, autoimmune diseases, COVID-19, and tuberculosis. Additionally, its role in regulating inflammation and gut microbiota is also being investigated.
    Conclusion: Overall, the immunomodulatory effects of metformin were investigated in anti-tumor, antiviral, anti-aging, and autoimmune disease research. This highlights the scope of metformin use in these fields, while also significantly enhancing its clinical value as a repurposed drug.
    Keywords:  aging; bibliometric analysis; immune checkpoint inhibition; immunomodulator; inflammation; metformin; tumor immune microenvironment
    DOI:  https://doi.org/10.3389/fimmu.2024.1526481
  50. Front Med (Lausanne). 2024 ;11 1506641
    Application of artificial intelligence in the health management of chronic disease: bibliometric analysis.
    Mingxia Pan, Rong Li, Junfan Wei, Huan Peng, Ziping Hu, Yuanfang Xiong, Na Li, Yuqin Guo, Weisheng Gu, Hanjiao Liu.
       Background: With the rising global burden of chronic diseases, traditional health management models are encountering significant challenges. The integration of artificial intelligence (AI) into chronic disease management has enhanced patient care efficiency, optimized treatment strategies, and reduced healthcare costs, providing innovative solutions in this field. However, current research remains fragmented and lacks systematic, comprehensive analysis.
    Objective: This study conducts a bibliometric analysis of AI applications in chronic disease health management, aiming to identify research trends, highlight key areas, and provide valuable insights into the current state of the field. Hoping our findings will serve as a useful reference for guiding further research and fostering the effective application of AI in healthcare.
    Methods: The Web of Science Core Collection database was utilized as the source. All relevant publications from inception to August 2024 were retrieved. The external characteristics of the publications were summarized using HistCite. Keyword co-occurrences among countries, authors, and institutions were analyzed with Vosviewer, while CiteSpace was employed to assess keyword frequencies and trends.
    Results: A total of 341 publications were retrieved, originating from 775 institutions across 55 countries, and published in 175 journals by 2,128 authors. A notable surge in publications occurred between 2013 and 2024, accounting for 95.31% (325/341) of the total output. The United States and the Journal of Medical Internet Research were the leading contributors in this field. Our analysis of the 341 publications revealed four primary research clusters: diagnosis, care, telemedicine, and technology. Recent trends indicate that mobile health technologies and machine learning have emerged as key focal points in the application of artificial intelligence in the field of chronic disease management.
    Conclusion: Despite significant advancements in the application of AI in chronic disease management, several critical challenges persist. These include improving research quality, fostering greater international and inter-institutional collaboration, standardizing data-sharing practices, and addressing ethical and legal concerns. Future research should prioritize strengthening global partnerships to facilitate cross-disciplinary and cross-regional knowledge exchange, optimizing AI technologies for more precise and effective chronic disease management, and ensuring their seamless integration into clinical practice.
    Keywords:  artificial intelligence; bibliometric analysis; chronic disease; health management; nursing care
    DOI:  https://doi.org/10.3389/fmed.2024.1506641
  51. J Multidiscip Healthc. 2025 ;18 223-238
    Large Language Models in Healthcare: A Bibliometric Analysis and Examination of Research Trends.
    Gülcan Gencer, Kerem Gencer.
       Background: The integration of large language models (LLMs) in healthcare has generated significant interest due to their potential to improve diagnostic accuracy, personalization of treatment, and patient care efficiency.
    Objective: This study aims to conduct a comprehensive bibliometric analysis to identify current research trends, main themes and future directions regarding applications in the healthcare sector.
    Methods: A systematic scan of publications until 08.05.2024 was carried out from an important database such as Web of Science.Using bibliometric tools such as VOSviewer and CiteSpace, we analyzed data covering publication counts, citation analysis, co-authorship, co- occurrence of keywords and thematic development to map the intellectual landscape and collaborative networks in this field.
    Results: The analysis included more than 500 articles published between 2021 and 2024. The United States, Germany and the United Kingdom were the top contributors to this field. The study highlights that neural network applications in diagnostic imaging, natural language processing for clinical documentation, and patient data in the field of general internal medicine, radiology, medical informatics, health care services, surgery, oncology, ophthalmology, neurology, orthopedics and psychiatry have seen significant growth in publications over the past two years. Keyword trend analysis revealed emerging sub-themes such as clinical research, artificial intelligence, ChatGPT, education, natural language processing, clinical management, virtual reality, chatbot, indicating a shift towards addressing the broader implications of LLM application in healthcare.
    Conclusion: The use of LLM in healthcare is an expanding field with significant academic and clinical interest. This bibliometric analysis not only maps the current state of the research, but also identifies important areas that require further research and development. Continued advances in this field are expected to significantly impact future healthcare applications, with a focus on increasing the accuracy and personalization of patient care through advanced data analytics.
    Keywords:  artificial intelligence; chatbot; clinical applications; diagnosis; healthcare; large language models; treatment recommendations
    DOI:  https://doi.org/10.2147/JMDH.S502351
  52. Curr Top Med Chem. 2025 Jan 21.
    Osseointegration Process Improving via Functionalization of Titanium Dioxide Nanotubes: A Bibliometric Analysis and Systematic Review.
    Sergio Murilo da Silva Braga Martins Junior, Jose Manuel Noguera Bazan, Lucas Dos Santos Silva, Luis Claudio Nascimento da Silva.
       INTRODUCTION/OBJECTIVES: Failures of osseointegrated implants pose a significant challenge in the medical field, often attributed to prolonged osseointegration periods and bacterial infections. Functionalization of Titanium Dioxide Nanotubes (TNTs) has emerged as a promising strategy to improve osseointegration and mitigate infections. This study aims to conduct a bibliometric analysis and systematic review to identify trends, gaps, and advancements in research on the functionalization of TNTs for osseointegration improvement.
    METHODS: Articles were retrieved from the Web of Science database using the keywords "osseointegration," "titanium dioxide nanotubes," and "functionalization." The inclusion criteria were studies published between 2014 and 2023, written in English, and focusing on the use of TNTs in implant surface modifications. A total of 126 articles were included after screening. Data extraction and analysis were performed using VOS Viewer, Microsoft Excel, and GraphPad Prism.
    RESULTS: The review revealed a growing number of publications on TNT functionalization, with China, the United States, and Brazil leading in contributions. Key findings include the effectiveness of TNTs loaded with bioactive agents (e.g., silver, strontium, hydroxyapatite) in promoting osseointegration and antibacterial activity. Collaborative networks among institutions and authors were mapped, highlighting the Sao Paulo State University and Yong Huang as the most prolific contributors.
    CONCLUSION: The findings underscore the potential of TNT functionalization to enhance implant performance. However, a gap remains in translating preclinical findings into clinical trials. Future research should focus on clinical validation to bridge this gap and translate laboratory advancements into therapeutic solutions.
    Keywords:  Implants; antibacterial activity.; biocompatibility; surface modification; titanium
    DOI:  https://doi.org/10.2174/0115680266334190241213101547
  53. Clin Otolaryngol. 2025 Jan 21.
    Article Retraction in Otolaryngology Journals: A Thirty Year Analysis.
    Albina S Islam, Elizabeth M Mastoloni, John E Fenton, Daniel H Coelho.
       OBJECTIVES: To gain insight into the integrity of research in Otolaryngology-Head & Neck Surgery (OHNS) literature through characterising retracted articles, analysing the reason for their retraction, and the trends in the collected data.
    METHODS: Pubmed, Embase, and Retraction Watch Database were queried for retracted articles published between the dates of 1/31/92 and 9/30/22. Articles with titles relating to OHNS subjects and published in OHNS journals, as determined by Scimago Journal and Country Ranking, were selected for further analysis. Variables recorded included journal name, journal impact factor, article type, article subspecialty subject, reason for retraction, whether re-published, number of authors, time to retraction, and article citations.
    RESULTS: Based on title and article content, 245 articles related to the field of OHNS were identified, of which 68 were published in OHNS journals and analysed for reason of retraction. Of those, 16 (23.5%) were replaced due to erratum concerns (spelling, formatting, etc.) rather than content or data-related issues and were excluded. Among the 52 (76.5%) permanent retractions the most common reasons for retraction include article duplication (n = 26), concerns/issues/errors with data (n = 7), and plagiarism (n = 5). The median time between publication and retraction was 2 years (range, 0-19). The median impact factor was 1.64 (range, 0.08-4.68). The median number of citations per article was 7 (range, 0-86).
    CONCLUSION: Retractions continue to occur in the field of OHNS despite increasing education in ethical publication standards and safeguards. There are, however, improved time intervals to retraction indicating improved surveillance of published articles.
    Keywords:  duplicate publication; plagiarism; retracted publication; retraction of publication; scientific misconduct
    DOI:  https://doi.org/10.1111/coa.14285
  54. Front Pharmacol. 2024 ;15 1523052
    Analysis of nanomedicine applications for inflammatory bowel disease: structural and temporal dynamics, research hotspots, and emerging trends.
    Hong-Yu Jiang, Bo Shao, Hong-Da Wang, Wen-Qi Zhao, Shao-Hua Ren, Yi-Ni Xu, Tong Liu, Cheng-Lu Sun, Yi-Yi Xiao, Yi-Cheng Li, Qiang Chen, Peng-Yu Zhao, Guang-Mei Yang, Xu Liu, Yu-Fan Ren, Hao Wang.
       Background: The application of nanomedicine in inflammatory bowel disease (IBD) has gained significant attention in the recent years. As the field rapidly evolves, analyzing research trends and identifying research hotpots are essential for guiding future advancements, and a comprehensive bibliometric can provide valuable insights.
    Methods: The current research focused on publications from 2001 to 2024, and was sourced from the Web of Science Core Collection (WoSCC). CiteSpace and VOSviewer were employed to visualize authors, institutions, countries, co-cited references, and keywords, thereby mapping the intellectual structure and identifying emerging trends in the field.
    Results: The analysis covered 1,518 literature across 447 journals, authored by 9,334 researchers from 5,459 institutions and 287 countries/regions. The global publication numbers exhibited an upward trend, particularly in the last decade, with China leading as the top publishing country and the Chinese Academy of Sciences emerging as the foremost institution. Dr. Xiao Bo is the prominent figure in advanced drug delivery systems. This interdisciplinary field, which spans materials science, pharmacy, and medicine, has seen influential publications mainly concentrated on targeted nanoparticles treatment for IBD. Keyword analysis revealed that current research hotspots include drug delivery, immune cell regulation, antioxidant damage, intestinal microbiota homeostasis, and nanovesicles.
    Conclusion: This study offers a comprehensive overview of global research landscape, emphasizing the rapid growth and increasing complexity of this field. It identifies key research hotspots and trends, including efforts to enhance the precision, efficacy, and safety of nanomedicine applications. Emerging directions are highlighted as crucial for further progress in this evolving area.
    Keywords:  bibliometrics; emerging frontiers; inflammatory bowel disease; nanomedicine; research trends
    DOI:  https://doi.org/10.3389/fphar.2024.1523052
  55. Behav Sci (Basel). 2024 Dec 30. pii: 27. [Epub ahead of print]15(1):
    Current Status and Future Directions of Artificial Intelligence in Post-Traumatic Stress Disorder: A Literature Measurement Analysis.
    Ruoyu Wan, Ruohong Wan, Qing Xie, Anshu Hu, Wei Xie, Junjie Chen, Yuhan Liu.
      This study aims to explore the current state of research and the applicability of artificial intelligence (AI) at various stages of post-traumatic stress disorder (PTSD), including prevention, diagnosis, treatment, patient self-management, and drug development. We conducted a bibliometric analysis using software tools such as Bibliometrix (version 4.1), VOSviewer (version 1.6.19), and CiteSpace (version 6.3.R1) on the relevant literature from the Web of Science Core Collection (WoSCC). The analysis reveals a significant increase in publications since 2017. Kerry J. Ressler has emerged as the most influential author in the field to date. The United States leads in the number of publications, producing seven times more papers than Canada, the second-ranked country, and demonstrating substantial influence. Harvard University and the Veterans Health Administration are also key institutions in this field. The Journal of Affective Disorders has the highest number of publications and impact in this area. In recent years, keywords related to functional connectivity, risk factors, and algorithm development have gained prominence. The field holds immense research potential, with AI poised to revolutionize PTSD management through early symptom detection, personalized treatment plans, and continuous patient monitoring. However, there are numerous challenges, and fully realizing AI's potential will require overcoming hurdles in algorithm design, data integration, and societal ethics. To promote more extensive and in-depth future research, it is crucial to prioritize the development of standardized protocols for AI implementation, foster interdisciplinary collaboration-especially between AI and neuroscience-and address public concerns about AI's role in healthcare to enhance its acceptance and effectiveness.
    Keywords:  Bibliometrix; CiteSpace; VOSviewer; algorithm; artificial intelligence; bibliometric analysis; digital psychiatry; post-traumatic stress disorder
    DOI:  https://doi.org/10.3390/bs15010027
  56. Acta Orthop Belg. 2024 Sep;90(3): 463-473
    The top 100 most-cited total knee arthroplasty publications.
    B DE Geofroy, J Ernat, P Froidefond, A Ghabi, M Peras, J-F Gonzalez, G Micicoi.
      The object is to objectively identify the 100 most influential scientific publications in total knee arthroplasty (TKA) and provide an analysis of their main characteristics. The Clarivate Analytics Web of Knowledge database was used to obtain data and metrics of TKA research. The search list was sorted by the number of citations, and articles were included or excluded based on relevance to TKA. The information extracted for each article included author name, publication year, country of origin, journal name, article type, and the level of evidence. These 100 studies generated a total of 35,399 cita- tions, with an average of 355.9 citations per article. The most-cited article was cited 1273 times. The 100 studies included in this analysis were published between 2000 and 2017. 23 different journals published these 100 publications. Majority of the publications were from United States (n = 52), followed by UK (n = 10) and Canada (n = 8). The most prevalent study designs were case series (n = 32) and cohort studies (n = 30). The 100 most influential articles in TKA were cited a total of 35,399 times. The study designs most prevalent were case series and cohort studies. This article serves as a reference to direct orthopedic surgeons to the 100 most influential studies in total knee arthroplasty. More than half of the studies are from North America, and three journals hold two-thirds of the 100 most cited publications on the topic.
    DOI:  https://doi.org/10.52628/90.3.12420
  57. Front Oncol. 2024 ;14 1465987
    Nanoparticles in gynecologic cancers: a bibliometric and visualization analysis.
    Yunzhe Zhou, Lizhang Chen, Tingting Wang.
       Background: Gynecological cancers are characterized by uncontrolled cell proliferation within the female reproductive organs. These cancers pose a significant threat to women's health, impacting life expectancy, quality of life, and fertility. Nanoparticles, with their small size, large surface area, and high permeability, have become a key focus in targeted cancer therapy. The aim of this study is to review recent advancements in nanoparticles applied to gynecologic cancers, providing valuable insights for future research.
    Methods: We retrieved all literature on nanoparticles in gynecologic cancers from the Web of Science Core Collection (WOSCC) database between January 1, 2004, and June 4, 2024. Data analysis and visualization were conducted using R software (version 4.4.0), VOSviewer (version 1.6.19.0), and CiteSpace (version 6.1).
    Results: A total of 2,843 publications from January 1, 2004, to June 4, 2024 were searched. Over the past 20 years, there has been a significant increase in publications. The leading countries and institutions in terms of productivity are China and the Chinese Academy of Sciences. The most prolific author and the most co-cited author are Sood, A K and Siegel, Rl. The top journals are the International Journal of Nanomedicine (n=97), followed by ACS Applied Materials & Interfaces (n=72) and Journal of Materials Chemistry B (n=53). Keyword analysis shows current research focuses on two main areas: the application of nanoparticles for drug delivery and their broader applications in gynecologic cancers. Future research will likely focus on "silver nanoparticles," "gold nanoparticles," and "green synthesis."
    Conclusions: Over the past two decades, nanoparticles have rapidly advanced in the field of gynecologic cancers. Research has primarily focused on the applications of nanoparticles in drug delivery and applications. Future trends point toward optimizing synthesis techniques and advancing preclinical studies to clinical applications, particularly for silver and gold nanoparticles. These findings provide valuable scientific insights for researchers.
    Keywords:  bibliometric analysis; gynecologic cancers; nanomaterials; nanoparticles; visualization analysis
    DOI:  https://doi.org/10.3389/fonc.2024.1465987
  58. Mar Drugs. 2025 Jan 10. pii: 34. [Epub ahead of print]23(1):
    Investigating Past, Present, and Future Trends on Interface Between Marine and Medical Research and Development: A Bibliometric Review.
    Mehdi Zamani, Tetyana Melnychuk, Anton Eisenhauer, Ralph Gäbler, Carsten Schultz.
      The convergence of marine sciences and medical studies has the potential for substantial advances in healthcare. This study uses bibliometric and topic modeling studies to map the progression of research themes from 2000 to 2023, with an emphasis on the interdisciplinary subject of marine and medical sciences. Building on the global publication output at the interface between marine and medical sciences and using the Hierarchical Dirichlet Process, we discovered dominating research topics during three periods, emphasizing shifts in research focus and development trends. Our data show a significant rise in publication output, indicating a growing interest in using marine bioresources for medical applications. The paper identifies two main areas of active research, "natural product biochemistry" and "trace substance and genetics", both with great therapeutic potential. We used social network analysis to map the collaborative networks and identify the prominent scholars and institutions driving this research and development progress. Our study indicates important paths for research policy and R&D management operating at the crossroads of healthcare innovation and marine sciences. It also underscores the significance of quantitative foresight methods and interdisciplinary teams in identifying and interpreting future scientific convergences and breakthroughs.
    Keywords:  bibliometric analysis; marine research; medical research; science mapping; text mining
    DOI:  https://doi.org/10.3390/md23010034
  59. World J Gastrointest Endosc. 2025 Jan 16. 17(1): 101382
    Insights into anesthesia administration for elderly individuals undergoing painless gastroenteroscopy: A bibliometric study.
    Gang Wang, Biao Zhen, Jia-Jun Li, Chun-Nv Jin, Jun Jia, Bo-Hai Liu, Yan-Hui Bai.
       BACKGROUND: Administering anesthesia to elderly patients undergoing gastroenteroscopy necessitates careful attention due to age-related physiological changes and an increased risk of complications.
    AIM: To analyze the research trends in anesthesia management for elderly patients undergoing gastroenteroscopy.
    METHODS: We performed a literature search using the Web of Science database to identify articles published between 2004 and 2023. Bibliometric and visual analyses were conducted using CiteSpace, R, and VOSviewer to explore the current research landscape of anesthesia administration in painless gastroenteroscopy for elderly patients and to identify future research directions by examining trends and emerging hotspots in this domain.
    RESULTS: A total of 800 articles were examined, revealing a rising trend in annual publication counts. The United States led with 181 articles, followed by China with 112, collectively contributing over 35% of the studies among the top ten countries. The majority of publications appeared in the United States journals, with the top three being Gastrointestinal Endoscopy [impact factor (IF) = 7.7, H-index = 26], Digestive Diseases and Sciences (IF = 3.1), and Endoscopy (IF = 9.3). Six primary research clusters were identified: Obstructive sleep apnea and airway management, surveillance and risk factors, colorectal cancer examination and treatment, sedation and safety of propofol and midazolam, patient satisfaction, and mortality and complications. These findings underscore the pivotal focus areas in anesthesia for elderly patients undergoing gastroenteroscopy.
    CONCLUSION: A comprehensive understanding of current research trends and hotspots will aid anesthesiologists in developing more evidence-based practices, thereby improving the safety and outcomes for elderly patients undergoing gastroenteroscopy.
    Keywords:  Anesthesia; Bibliometric; CiteSpace; Elderly; Gastroenteroscopy; VOSviewer
    DOI:  https://doi.org/10.4253/wjge.v17.i1.101382
  60. World J Microbiol Biotechnol. 2025 Jan 23. 41(2): 45
    Global landscape of Vibrio parahaemolyticus research: a bibliometric analysis.
    Nor Hafizah Zakaria, Noorul Darlina Edlin Abd Rahim, Nur Fathiah Rosilan, Yeong Yik Sung, Khor Waiho, Sarahani Harun, Rabiatul Adawiah Zainal Abidin, Nor Afiqah-Aleng.
      Vibrio parahaemolyticus poses a notable threat to marine ecosystems and can cause infections and disease outbreaks in seafood species, which can affect humans upon consumption. The global impacts of such infections and outbreaks on human and animal health led to a growing number of studies from various countries discussing the prevention, control, treatment, and overall implications of V. parahaemolyticus. Hence, this study aims to retrieve relevant studies on V. parahaemolyticus using a bibliometric analysis to understand current research status, trends, and hotspots regarding this bacteria. Relevant literature was searched across the Scopus database, and the data were subsequently analyzed using Biblioshiny software. In addition, a manual examination was conducted to identify the hosts of V. parahaemolyticus and diseases caused by the bacteria. Overall, 7,096 records were obtained from Scopus from 1963 to 2023. A bibliometric analysis identified 17,220 authors, with China emerging as the global leader. The analysis also highlighted significant keywords such as "Vibrio parahaemolyticus," "Litopenaeus vannamei," and "innate immunity," suggesting a focus on the impact of V. parahaemolyticus on L. vannamei, specifically emphasizing the shrimp's innate immune responses. Host-disease interaction network also uncovered 53 interactions between hosts and diseases involving L. vannamei or Penaeus vannamei as the primary host, with acute hepatopancreas necrosis disease (AHPND) emerging as the most prevalent among them. This study can enhance our understanding of infections caused by V. parahaemolyticus and contribute to the development of effective strategies for their prevention and management.
    Keywords:   Penaeus vannamei ; Vibrio parahaemolyticus ; Bibliometric; Host-disease interaction; Immunity
    DOI:  https://doi.org/10.1007/s11274-025-04262-5
  61. Nurs Crit Care. 2025 Jan 24.
    Unveiling the conceptual and intellectual map of care bundle research in ICUs: Trends, key issues, and collaborative networks.
    İlknur Özkan, Cansu Polat Dünya, Seçil Taylan.
       BACKGROUND: Care bundles are evidence-based practices intended to improve patient outcomes and have become a significant focus in intensive care.
    AIM: This study aims to identify research trends, key topics, leading researchers, and significant collaborations in care bundle research within ıntensive care units by mapping the conceptual and intellectual structure of the field.
    STUDY DESIGN: Data were collected from the Web of Science database, covering publications from 2010 to 2024. The search terms included 'bundle*' or 'bundle* care' and 'intensive care unit' or 'critical care'. The analysis used tools like the Biblometrix package in R and VOSviewer, focusing on performance metrics, co-citation analysis, co-occurrence network analysis, and thematic mapping.
    RESULTS: The annual growth rate of publications on care bundles is 6.26%. The most prolific journals include Critical Care Medicine, the American Journal of Infection Control, and Infection Control and Hospital Epidemiology. Thematic mapping shows research is concentrated on critical areas such as infection control, patient safety, and quality improvement. While some themes, like 'intensive care units' and 'central line-associated bloodstream infection', are well-developed and central, others like 'maternal safety consensus' and 'safety consensus bundle' are highly developed but less central. Emerging themes like 'acute kidney injury' suggest potential areas for future research.
    CONCLUSIONS: This bibliometric analysis offers a comprehensive overview of intensive care unit care bundle research, highlighting a strong focus on critical issues like infection control, patient safety, and care quality improvement.
    RELEVANCE TO CLINICAL PRACTICE: The study provides crucial insights for clinical practice by identifying key research trends and underexplored topics related to intensive care unit care bundles. These findings can guide the development of more effective care protocols, promote multidisciplinary collaboration, and enhance healthcare professional education, ultimately contributing to optimized patient care and high standards in the intensive care unit through improved care bundle implementation.
    Keywords:  bibliometric analysis; bundle; bundle care; critical care unit; intensive care unit
    DOI:  https://doi.org/10.1111/nicc.13234
  62. J Gastrointest Cancer. 2025 Jan 23. 56(1): 51
    Trends in Colorectal Cancer Peritoneal Metastases Research: A Comprehensive Bibliometric Analysis.
    Yuzhe Zhang, Zi Jin, Zhongqing Wang, Lirong Yan, Aoran Liu, Fang Li, Yanke Li, Ye Zhang.
       BACKGROUND: Colorectal cancer (CRC) stands as the third most prevalent malignancy globally and is recognized as the second leading cause of cancer-related mortality. Notably, nearly 50% of individuals diagnosed with CRC ultimately develop metastatic disease, with the peritoneum emerging as the second most frequent site for metastatic spread. Recent advancements in therapeutic frameworks have enhanced both survival rates and quality of life metrics for patients afflicted with colorectal cancer peritoneal metastases (CRCPM).
    OBJECTIVE: This study endeavors to facilitate an in-depth review of the current scientific landscape surrounding CRCPM, ultimately aiming to delineate future avenues for investigative research in this realm.
    METHODS: Employing R software through the Bibliometrix package, alongside analytical tools such as CiteSpace and VOSviewer, we performed a comprehensive bibliometric analysis. This enabled us to assess pivotal keywords, prominent authors, influential countries, notable institutions, relevant literature, and key journals pertinent to the field of CRCPM research.
    RESULTS: Our findings illustrate a significant uptick in the volume of publications addressing CRCPM, with the USA leading in overall contribution, complemented by substantial input from distinguished scholars in the Netherlands and France. The author Ignace H. J. T. de Hingh emerged as the most prolific contributor. Current research endeavors have predominantly focused on the characterization of primary malignancies with peritoneal metastases, therapeutic interventions for CRCPM, and the orchestration of clinical trials.
    CONCLUSION: This analysis culminates in a systematic encapsulation of the prevailing research findings concerning CRCPM, underscoring current hotspots and predicting future trends within the global research spectrum. The exploration of treatment modalities for CRCPM remains vibrant, and ongoing multicenter clinical trials are anticipated to further enrich our understanding and management of this challenging clinical issue.
    Keywords:  Bibliometric; Colorectal cancer; Peritoneal metastases; Trial
    DOI:  https://doi.org/10.1007/s12029-025-01176-1
  63. Rev Environ Health. 2025 Jan 24.
    School built environment and children's health: a scientometric analysis.
    Mingxin Zhang, Xue Meng.
      The school built environment is closely related to children's health, and research on this topic is increasing. However, bibliometric analyses seeking to provide a comprehensive understanding of the research landscape and key themes in the field are lacking. This study comprehensively explored the global trends and research hotspots on the associations between school built environment and children's health. We used a scientometric analysis to review the research progress. The temporal distribution of publications, scientific collaborations, research hotspots, research frontiers, and co-citations over the past 30 years were analyzed. The results show that the number of publications in this field rose significantly between 1987 and 2025, with research hotspots focusing on physical activity, performance, behavior, perception, thermal comfort, and indoor air quality. Environmental themes related to children's health fall into four main groups: the built environment related to children's activities, intelligent learning environments, indoor environments and interiors, and natural environments. Health outcomes and measures that reflect physiological, psychological, cognitive, behavioral, and physical factors are discussed. This study provides a broad understanding of research issues and trends related to the school built environment and children's health.
    Keywords:  bibliometrics; children; educational building; physical environment; public health; school environment
    DOI:  https://doi.org/10.1515/reveh-2024-0137
  64. BMJ Open. 2025 Jan 22. 15(1): e086982
    Diversity in the medical research ecosystem: a descriptive scientometric analysis of over 49 000 studies and 150 000 authors published in high-impact medical journals between 2007 and 2022.
    Marie-Laure Charpignon, Joao Matos, Luis Filipe Nakayama, Jack Gallifant, Pia Gabrielle I Alfonso, Marisa Cobanaj, Amelia Morel Fiske, Alexander J Gates, Frances Dominique V Ho, Urvish Jain, Mohammad Kashkooli, Naira Link, Liam G McCoy, Jonathan Shaffer, Leo Anthony Celi.
       OBJECTIVES: Health research that significantly impacts global clinical practice and policy is often published in high-impact factor (IF) medical journals. These outlets play a pivotal role in the worldwide dissemination of novel medical knowledge. However, researchers identifying as women and those affiliated with institutions in low- and middle-income countries (LMICs) have been largely under-represented in high-IF journals across multiple fields of medicine. To evaluate disparities in gender and geographical representation among authors who have published in any of five top general medical journals, we conducted scientometric analyses using a large-scale dataset extracted from the New England Journal of Medicine, Journal of the American Medical Association, The BMJ, The Lancet and Nature Medicine.
    METHODS: Author metadata from all articles published in the selected journals between 2007 and 2022 were collected using the DimensionsAI platform. The Genderize.io Application Programming Interface was then used to infer each author's likely gender based on their extracted first name. The World Bank country classification was used to map countries associated with researcher affiliations to the LMIC or the high-income country (HIC) category. We characterised the overall gender and country income category representation across the five medical journals. In addition, we computed article-level diversity metrics and contrasted their distributions across the journals.
    RESULTS: We studied 151 536 authors across 49 764 articles published in five top medical journals, over a period spanning 15 years. On average, approximately one-third (33.1%) of the authors of a given paper were inferred to be women; this result was consistent across the journals we studied. Further, 86.6% of the teams were exclusively composed of HIC authors; in contrast, only 3.9% were exclusively composed of LMIC authors. The probability of serving as the first or last author was significantly higher if the author was inferred to be a man (18.1% vs 16.8%, p<0.01) or was affiliated with an institution in a HIC (16.9% vs 15.5%, p<0.01). Our primary finding reveals that having a diverse team promotes further diversity, within the same dimension (ie, gender or geography) and across dimensions. Notably, papers with at least one woman among the authors were more likely to also involve at least two LMIC authors (11.7% vs 10.4% in baseline, p<0.001; based on inferred gender); conversely, papers with at least one LMIC author were more likely to also involve at least two women (49.4% vs 37.6%, p<0.001; based on inferred gender).
    CONCLUSION: We provide a scientometric framework to assess authorship diversity. Our research suggests that the inclusiveness of high-impact medical journals is limited in terms of both gender and geography. We advocate for medical journals to adopt policies and practices that promote greater diversity and collaborative research. In addition, our findings offer a first step towards understanding the composition of teams conducting medical research globally and an opportunity for individual authors to reflect on their own collaborative research practices and possibilities to cultivate more diverse partnerships in their work.
    Keywords:  Health informatics; Medical Education & Training; Medicine
    DOI:  https://doi.org/10.1136/bmjopen-2024-086982
  65. Probiotics Antimicrob Proteins. 2025 Jan 24.
    Bibliometric Analysis of Probiotic Bacillus in Food Science: Evolution of Research Trends and Systematic Evaluation.
    Lijun Zhao, Shijie Liu, Miaoyun Li, Jong-Hoon Lee, Yaodi Zhu, Dong Liang, Huihui Zhi, Qian Ding, Gaiming Zhao, Yangyang Ma, Lingxia Sun, Yanxia Liu.
      With the in-depth and comprehensive research on probiotic Bacillus, it has become a hot topic in food science. However, the current status of research using bibliometric analysis to assess the application of probiotic Bacillus in food science has not been comprehensively reviewed. The Web of Science (WOS) database was used in this review's bibliometric analysis to determine the hotspots for research as well as the extent of completed experiments. Furthermore, a systematic review was conducted on the research hotspots of probiotic Bacillus in food science. The comprehensive analysis showed it was a growing and global research field. The keywords with high frequency mainly included "spore," "strain," and "production," which were research hot topics in the last decade. The application of the spore form or nutrient cells of probiotic Bacillus in industrialized food production through nutrient fortification, fermentation agents, and highly efficient synthesis of metabolites showed great development potential.
    Keywords:  Bibliometric analysis; Cell factory; Fermentation agents; Nutritional fortifiers; Probiotic Bacillus
    DOI:  https://doi.org/10.1007/s12602-025-10457-x
  66. Front Immunol. 2024 ;15 1511866
    The global trends and distribution in tumor-infiltrating lymphocytes over the past 49 years: bibliometric and visualized analysis.
    Beibei Wu, Ding Luo, Xuejie Wang, Chen Qiao, Rui Li, Jian Liu.
       Background: The body of research on tumor-infiltrating lymphocytes (TILs) is expanding rapidly; yet, a comprehensive analysis of related publications has been notably absent.
    Objective: This study utilizes bibliometric methodologies to identify emerging research hotspots and to map the distribution of tumor-infiltrating lymphocyte research.
    Methods: Literature from the Web of Science database was analyzed and visualized using VOSviewer, CiteSpace, Scimago Graphica, R-bibliometrix, and R packages.
    Results: Research on tumor-infiltrating lymphocytes began in 1975 and has experienced significant growth, particularly after 2015. Leading contributors include the United States, the National Cancer Institute, the journal Cancer Immunology Immunotherapy, and researcher Steven A. Rosenberg. Other prominent contributors include China, the National Institutes of Health, researcher Roberto Salgado, and the Journal of Immunology. Prominent institutions in the USA and Europe occupy central roles within collaborative networks. Financial support plays a pivotal role in driving research advancements. Keyword clustering analysis reveals four primary knowledge domains: adoptive cell therapy; the prognostic value of TILs; PD-1/PD-L1 and TILs; and prognostic studies of TILs across various cancers. Keyword and reference analyses further indicate that "adoptive cell therapy," "the prognostic value of TILs," and "immune checkpoint inhibitors and TILs" are central themes in current and future research. Combination therapies; tumor neoantigens; gene editing; dominant population selection of TILs therapy; TILs in Tumor microenvironment; emerging predictive biomarkers; TILs in predicting the efficacy of neoadjuvant chemotherapy and immunotherapy; the relationship between TILs and PD-L1; TIL-based patient stratification; tertiary lymphoid structures; and TIL evaluation through digital pathology and artificial intelligence are identified as key areas of interest.
    Conclusions: This analysis highlights the increasing academic focus on tumor-infiltrating lymphocyte research and identifies key recent themes in the field such as prognostic value of TILs, personalized treatments, and combination therapies.
    Keywords:  PD-L1; adoptive cell therapy; bibliometrics; predictive biomarker; tumor-infiltrating lymphocytes
    DOI:  https://doi.org/10.3389/fimmu.2024.1511866
  67. Arch Plast Surg. 2025 Jan;52(1): 46-52
    Application of the Relative Citation Ratio to Assess Common Characteristics of the Highest Impact Articles in Reconstructive Microsurgery.
    Amir-Ala Mahmoud, Dominick J Falcon, Valeria P Bustos, Maria J Escobar-Domingo, Bernard T Lee.
      Background  The purpose of this review is to characterize themes among the five reconstructive microsurgery articles achieving the highest Relative Citation Ratios (RCRs) published in the past 20 years in the top journals. In doing so, researchers may be better informed on how to propose salient research questions to impact the field and understand future directions in plastic surgery. Methods  A cross-sectional study was conducted with articles published in the top three journals based on the Impact Factor: Plastic and Reconstructive Surgery, Journal of Reconstructive Microsurgery, and Annals of Plastic Surgery. A search strategy with controlled vocabulary and keywords was conducted in PubMed to extract all reconstructive microsurgery (RM) articles published between 2002 and 2020. A two-stage screening process to include only RM studies was performed, with a third reviewer moderating discordances. Articles' RCR data were extracted from the National Institutes of Health iCite. The top five articles with the highest RCRs were selected for analysis. Results  We identified three features reflecting educational and clinical trends within RM that might be representative of super-performance in plastic surgery journals. These include (1) relevance to high-yield techniques in RM such as tissue flap procurement, indications, and outcomes, (2) identification of gaps in current knowledge of these topics, and (3) use of media and algorithms to provide clear recommendations. Conclusion  Researchers hoping to have an impactful contribution should pose research questions that address these key themes. The RCR index is a valuable tool to appreciate performance within microsurgery literature and clinical trends within the field.
    Keywords:  free tissue flap; microsurgery; plastic surgery; reconstructive surgery; relative citation ratio
    DOI:  https://doi.org/10.1055/a-2380-4278
  68. Diabetes Metab Syndr. 2025 Jan 16. pii: S1871-4021(25)00008-6. [Epub ahead of print]19(2): 103191
    Response to the Letter to the Editor regarding "Global research trends and hotspots in gestational diabetes and long-term cardiovascular health: A bibliometric analysis."
    Yanxi Jia, Qing Hu, Hua Liao, Hongyan Liu, Zhaomin Zeng, Haiyan Yu.
      
    Keywords:  Bibliometric analysis; Cardiovascular health; Gestational diabetes
    DOI:  https://doi.org/10.1016/j.dsx.2025.103191
  69. Front Res Metr Anal. 2024 ;9 1484685
    Patent research in academic literature. Landscape and trends with a focus on patent analytics.
    Cristian Mejia, Yuya Kajikawa.
      Patent analytics is crucial for understanding innovation dynamics and technological trends. However, a comprehensive overview of this rapidly evolving field is lacking. This study presents a data-driven analysis of patent research, employing citation network analysis to categorize and examine research clusters. Here, we show that patent research is characterized by interconnected themes spanning fundamental patent systems, indicator development, methodological advancements, intellectual property management practices, and diverse applications. We reveal central research areas in patent strategies, technological impact, and patent citation research while identifying emerging focuses on environmental sustainability and corporate innovation. The integration of advanced analytical techniques, including AI and machine learning, is observed across various domains. This study provides insights for researchers and practitioners, highlighting opportunities for cross-disciplinary collaboration and future research directions.
    Keywords:  bibliometrics; network analysis; patent analytics; tech mining; text mining
    DOI:  https://doi.org/10.3389/frma.2024.1484685
  70. Heliyon. 2025 Jan 15. 11(1): e41109
    Agriculture data sharing review.
    Jorge Chamorro-Padial, Jordi Virgili-Gomá, Rosa Gil, Mercè Teixidó, Roberto García.
      This study conducts a bibliometric analysis of 252 scientific publications from 2001 to 2023, exploring the evolution and emerging trends in agricultural data spaces. Analyzing articles from the Web of Science and Scopus databases, we address six research questions: the current and interconnected key topics in agricultural data spaces (RQ1), the evolution of research themes over time (RQ2), emerging trends in the field (RQ3), the identification of leading researchers (RQ4), and the primary funding sources for this research area (RQ5), the relationship among research data and small farmers (RQ6). Our findings reveal a shift from traditional to innovative research themes, such as the increasing focus on the Internet of Things (IoT), Blockchain, and Digital Storage. This indicates a trend toward modernizing agricultural practices through technology. We found that the rise of these topics is not correlated with the results shown by Google Scholar for these same terms but is correlated with the economic impact of such areas. Prominent authors and significant funding sources, including the European Union, the United States Department of Agriculture, and Chinese research programs, have been identified, proving the global interest and investment in the digitalization of agriculture. We continue our analysis by identifying some barriers that prevent small farmers from using or sharing research data, among them cultural contexts, lack of trust in providers, and ignorance of terms and conditions. This study offers valuable insights for researchers, policymakers, and practitioners, focusing on the evolution of the dynamic landscape of agricultural data spaces and potential future innovations in fields like data analytics and Artificial Intelligence, Internet of Things, Blockchain, digital divide and digital farming platforms. Our findings emphasize the necessity for targeted policy interventions and support mechanisms to bridge the gap and enable small and medium farmers to benefit from advancements in agricultural data spaces and digitization.
    Keywords:  Agriculture; Bibliometric analysis; Data sharing; Data space; Digital transformation in agriculture; Digitalization; Farmers; Technological advancements in agricultural data
    DOI:  https://doi.org/10.1016/j.heliyon.2024.e41109
  71. Medicine (Baltimore). 2025 Jan 17. 104(3): e41272
    A brief examination of literature on adult cystic fibrosis: An emerging topic.
    Oguz Karcioglu, Elif Naz Sancar, Asli Alkan.
      Cystic fibrosis (CF), a historically fatal childhood disease, now became a manageable adulthood disease. The transition of the disease to adulthood and the patients to adult physicians raised a new question: What is the extent of adult physicians' contributions to CF literature? We examined the data of all CF publications from Web of Sciences between 1945 and 2023. We determined the adult CF articles by searching for the term "adult" in titles. We analyzed the data in terms of publication years, study types, countries, and languages. A total of 30,944 articles examined. From 1945 to 2023, both the number of published articles (88-10,460), and the number of publishing journals (31-1770) on CF have increased. The number of articles on adult CF has also increased, from only 3 in the first 3 decades up to 716 between 2010 and 2019. While pediatrics was initially the leading journal with the highest number of articles published on CF, general medicine journals, and finally the Journal of Cystic Fibrosis became the leading publisher. The USA were the most productive country on behalf of publication on CF. The increasing number of annual publications clearly shows the growing interest in CF. The increase in the number of articles on adult CF along with the increase in publishing journals provide evidence that the disease is now acknowledged as a disease concerning adults.
    DOI:  https://doi.org/10.1097/MD.0000000000041272
  72. Mol Biotechnol. 2025 Jan 22.
    Research Trends and Development Dynamics of qPCR-based Biomarkers: A Comprehensive Bibliometric Analysis.
    Li Liu, Ben-Rong Mu, Ya Zhou, Qing-Lin Wu, Bin Li, Dong-Mei Wang, Mei-Hong Lu.
      Quantitative polymerase chain reaction (qPCR) is a vital molecular technique for biomarker detection; however, its clinical application is impeded by the scarcity of robust biomarkers and the inherent limitations of the technology. This study conducted a bibliometric analysis of 4063 qPCR-based biomarker studies sourced from the Web of Science (WOS) database, employing VOSviewer and CiteSpace to generate multi-dimensional structural insights into this field. The results reveal a growing trend in research within this domain, with gene expression analysis playing a central role in the identification of potential biomarkers. Among these, cancer-related biomarkers are the most prominent, while research on biomarkers for other diseases remains limited. Liquid biopsy biomarkers, including microRNA (miRNA), circulating free DNA (cfDNA), and circulating tumor DNA (ctDNA), are increasingly being explored. The integration of bioinformatics, omics analysis, and high-throughput technologies with qPCR is accelerating biomarker discovery. Furthermore, large-scale parallel sequencing is emerging as a potential alternative to relative quantification and microarray techniques. Nevertheless, qPCR remains essential for validating specific biomarkers, and further standardization of its protocols is necessary to enhance reliability. This study provides a systematic analysis of qPCR-based biomarker research and underscores the need for future technological integration and standardization to facilitate broader clinical applications.
    Keywords:  Bibliometric analysis; Biomarkers; Quantitative polymerase chain reaction (qPCR); Research hotspots; Research trends
    DOI:  https://doi.org/10.1007/s12033-024-01356-7
  73. Cent Eur J Public Health. 2024 Dec;32(Supplement): 72-77
    Findings on impact of COVID-19 on mental health using keyword visualization.
    Gabriela Štefková, Kvetoslava Rimárová, Erik Dorko, Lucia Dimunová, Martina Tejová.
       OBJECTIVE: The EU global health priorities focus on ensuring better health and well-being for people throughout their lives as well as on reducing inequalities between countries. The COVID-19 pandemic can be understood as a set of several events that directly or indirectly affected the mental health of people around the world. The aim of this study was to identify the main groupings of co-occurrence of all keywords related to the main keywords "COVID-19" and "mental health" acquired through search in the Scopus database using the VOSviewer tool.
    METHODS: Descriptive study based on a bibliometric analysis of the occurrence of the keywords "COVID-19" and "mental health" in scientific articles retrieved from the Scopus database on 31 January 2023 covering period from 2020 to 2022 plus January 2023 in the field of medical research. The result was 1,625 articles extracted into a csv file and inserted into VOSviewer tool. By counting the number of co-occurrences of keywords using the VOSviewer, the final result was 1,211 keywords. Out of the 1,211 keywords 44 different keywords with the total power link strength of association with the keywords "COVID-19" and "mental health" were selected.
    RESULTS: The presence of high rates and power links of depression and anxiety after the pandemic situation has been confirmed by visualization of keywords in scientific articles retrieved from Scopus database. The keywords "social support", "social isolation", "perceived social support", and "dementia" inform us about potential areas of research and trigger discussion about the impact of the recent pandemic on mental health. Another warning was the occurrence of the keyword "obesity" and its association with health consequences for individuals and society. Among all countries, the United States, the United Kingdom and China contributed the most with scientific publications focusing on pandemic and mental health.
    CONCLUSION: The visualization of the keywords "COVID-19" and "mental health", specifically "depression" and "anxiety" create a new area for further research as well as establishing preventive measures leading to protection from mental health damage in the events of possible dangers of this type.
    Keywords:  VOSviewer; anxiety; depression; obesity; social isolation
    DOI:  https://doi.org/10.21101/cejph.a8281
  74. Minerva Dent Oral Sci. 2025 Jan 20.
    Retracted articles in endodontic-related literature: an analysis of 60 cases.
    Giovanni Mergoni, Benedetta Ghezzi, Andrea Salvaterra Toffoli, Maddalena Manfredi.
       INTRODUCTION: The number of retracted articles in the bio-medical field, including dentistry, is increasing. The objective of this study was to identify retracted articles in endodontic-related literature and outline their main characteristics.
    EVIDENCE ACQUISITION: The Medline and Scopus databases were searched in January 2024. Additional records were identified by consulting the online database www.retractiondatabase.org. Retracted articles concerning endodontic topics and the relative retraction notes were retrieved and relevant data extracted.
    EVIDENCE SYNTHESIS: Sixty articles were identified, published between 2004 and 2022, with a mean of 3.0±2.3 retracted articles per year. The number of retracted articles per year did not significantly grow over time. The average time between the article and retraction note publication was 36.1±22.3 months. The majority of articles originated from Asia and were in-vitro studies. Only 6.7% of the articles were retracted due to honest errors. The main reasons of retraction were image/data manipulation (20%), plagiarism (18%), unavailability of raw data (10%), authorship issues (10%) and publication process issues (10%). A single research group accounted for 17 retractions.
    CONCLUSIONS: Unlike the dental field, the number of retracted articles in endodontics has not increased significantly over the time period considered. Despite this, controls against research misconduct must be increased to preserve the credibility of scientific research.
    DOI:  https://doi.org/10.23736/S2724-6329.24.05043-5
  75. PLoS One. 2025 ;20(1): e0316913
    Inequality in measuring scholarly success: Variation in the h-index within and between disciplines.
    Ryan Light, Aaron Gullickson, Jill Ann Harrison.
      Scholars and university administrators have a vested interest in building equitable valuation systems of academic work for both practical (e.g., resource distribution) and more lofty purposes (e.g., what constitutes "good" research). Well-established inequalities in science pose a difficult challenge to those interested in constructing a parsimonious and fair method for valuation as stratification occurs within academic disciplines, but also between them. The h-index, a popular research metric, has been formally used as one such method of valuation. In this article, we use the case of the h-index to examine how the distribution of research metrics reveal within and between discipline inequalities. Using bibliometric data from 1960-2019 on over 50,000 high performing scientists-the top 2% most frequently cited authors-across 174 disciplines, we construct random effects within-between models predicting the h-index. Results suggest significant within-discipline variation in several forms, specifically sole-authorship and female penalties. Results also show that a sole authorship penalty plays a significant role in well-known between-discipline variation. Field-specific models emphasize the "apples-to-oranges," or incommensurable, property of cross-discipline comparison with significant heterogeneity in sole-authorship and female penalties within fields. In conclusion, we recommend continued caution when using the h-index or similar metrics for valuation purposes and the prioritization of substantive valuations from disciplinary experts.
    DOI:  https://doi.org/10.1371/journal.pone.0316913
  76. Microb Pathog. 2025 Jan 21. pii: S0882-4010(25)00040-3. [Epub ahead of print] 107315
    Bibliometric analysis of neurocysticercosis case reports and evaluation of presented cases.
    Esra Gürbüz, Selahattin Aydemir, Fethi Barlik, Murat Saygin, Rahmi Yildiz, Sevil Alkan, Abdurrahman Ekici.
      Neurocysticercosis (NCC) has been classified as a neglected tropical disease by the World Health Organization (WHO), with the condition being regarded as the most significant parasitic disease affecting the nervous system. Hence, the aim of this study was to conduct a review of previously published case reports on this topic in order to ascertain whether there is an increasing trend of NCC worldwide and evaluate the cases that have been presented. After a comprehensive search of the Web of Science Core Collection using the keywords "neurocysticercosis" and "case reports", studies were selected by applying inclusion criteria. Important data attributes that were extracted in plain text format included the document titles, publication years, journal names, author(s) name(s), keywords, institutions, and countries. In addition, to evaluate the cases, the age and gender of the patients, complaints on admission, localization of the cyst, and treatment procedure used were recorded in an Excel file. The bibliometric analysis was conducted using Biblioshiny. Additionally, GraphPad and Excel were employed for the creation of graphical representations. The dataset analyzed included 297 documents, 162 from various sources, with an average age of 12.2 years and 6.3 citations per document. The number of case reports tended to increase over the years. India and the USA were the leading contributors to NCC case reports, with 78 (26.3%) and 64 (21.5%), respectively. This was followed by Brazil, France, and Spain with 31 (10.4%), 14 (4.7%) and 13 (4.4%) case reports, respectively. Moreover 55.5% of the patients in the cases presented in the articles were male and 12.9% were in the 21-25 age group. In regard to the cysts, 81.2% were located in the brain and 15.1% were in the spine. The most common complaints were headache and seizures in brain localized NCC cases and back pain and numbness or weakness in extremities in spine localized NCC cases. Albendazole was used in 174 (54.5%) cases, praziquantel in 22 (6.9%) cases, and ivermectin in five (1.6%) cases. In conclusion, NCC continues to be an increasingly serious public health problem in India as well as developed countries such as the USA and European countries. NCC can be seen in all age groups, males are more susceptible than females, cysts are more localized in the ventricular system, and albendazole and/or paraziquentel are used in treatment. In addition, more comprehensive studies on the use of ivermectin in the treatment of NCC should be conducted, as success was achieved in cases where ivermectin was used in treatment.
    Keywords:  Neurocysticercosis; Taenia solium; case reports; epilepsy; ivermectin
    DOI:  https://doi.org/10.1016/j.micpath.2025.107315
  77. Int Orthop. 2025 Jan 24.
    Spin is Prevalent in the Abstracts of Systematic Reviews and Meta-Analyses Comparing Biceps Tenodesis and Tenotomy Outcomes.
    Karim Khaled, Raed Alderhali, Jordan Helbing, Osama Alzobi, Bashir Zikria.
       PURPOSE: This study aimed to assess the presence of spin in abstracts of systematic reviews and meta-analyses comparing biceps tenodesis and tenotomy outcomes and to explore associations between spin and specific study characteristics.
    METHODS: Using Web of Science and PubMed databases, systematic reviews and meta-analyses comparing outcomes of biceps tenodesis and tenotomy were identified. Abstracts were evaluated for the nine most severe types of spin as described by Yavchitz et al. and appraised using the AMSTAR 2 (A MeaSurement Tool to Assess systematic Reviews). Study characteristics were extracted, including adherence to PRISMA guidelines,funding status, and impact metrics such as journal impact factor, total number of citations, and average annual citations.
    RESULTS: A total of 16 studies were included, with spin detected in 81.3% of the abstracts. Type three spin was the most frequent (56.3%), followed by types six (43.8%), five (37.5%), nine (25.0%), two (12.5%), and four (6.3%). Spin types one, seven, and eight were not observed. AMSTAR 2 appraised 75% of the studies as 'low' quality, and 25% as 'critically low' quality. All studies had at least one critical flaw, with item 15 (investigation of publication bias) being the most frequent (93.8%). A strong positive correlation was found between AMSTAR 2 scores and citation counts (r = 0.821, p < 0.001). Studies with a higher number of spin incidents were significantly more likely to have an associated letter to the editor (p = 0.0043).
    CONCLUSION: Severe types of spin were prevalent in the abstracts of systematic reviews and meta-analyses comparing biceps tenodesis and tenotomy. Data analysis suggests that abstracts with a higher incidence of spin tend to attract more scrutiny from the academic community. These findings highlight the need to enhance reporting standards.
    Keywords:  Biceps tenodesis; Biceps tenotomy; LHBT; Meta-analysis; Spin; Systematic review
    DOI:  https://doi.org/10.1007/s00264-025-06414-6
  78. PLOS Glob Public Health. 2025 ;5(1): e0003972
    Disparities of women's authorship in Colombia: A cross-sectional analysis.
    María Alejandra Gutiérrez Torres, Silvana Ruiz, Karen Morales, Laura Rincon, Frans Serpa, Camila Gómez, Michelle M Ahrens, Felipe Duran, Abul Ariza Manzano, Santiago Callegari.
      Accepted manuscripts published in medical journals play a crucial role within the scientific community. Over the past few decades, there has been a gradual increase in the number of women entering the medical field. However, women remain underrepresented as first and last authors in medical journals. This lack of representation makes it harder for them to reach leadership roles and advance academically. Even if this has been studied in high-income countries, low- and middle-income countries still lack evidence to prove this fundamental problem. This study aims to do this by investigating the gender distribution among authors and exploring disparities in authorship in Colombia. The analysis encompassed 6,088 articles derived from 54 research journals obtained from the official website of Colombia's Ministry of Health. The journals included enhance the significance of this paper, as they are typically not included in indexed databases. Consequently, their inclusion in gender evaluations has been limited in previous studies. These were predominantly original research articles, although case reports and reviews were also present. Until now, there has been no assessment of gender disparities in authorship within medical and surgical specialty journals in Colombia. The presence of enduring gender differences in medical authorship in Colombia remains evident, independent of the temporal, geographical, or academic domain. Even when factors such as medical specialization and geographic location influenced women's authorship proportions, the gap persisted in all cases. This highlights the critical need for increased support for women researchers and equitable resource allocation to address the specific medical specializations as well as geographical locations that we found were even more affected by these gender disparities. This paper highlights the urgent need to address gender disparities in the authorship of medical and surgical research publications in Colombia and other Latin American countries. Addressing these disparities is a critical step toward assisting women in advancing in an equal and fair medical profession.
    DOI:  https://doi.org/10.1371/journal.pgph.0003972
  79. ANZ J Surg. 2025 Jan 21.
    Characterization of academic output (h-index) by Australian urologists according to gender and rurality.
    Jessica A Paynter, Eugene Wang, Jessica Wynn, Kirby R Qin, Janelle Brennan.
       BACKGROUND: As the number of practicing female urologists in Australia continues to increase alongside the academic development of the specialty, it is essential to examine how gender and rurality impact academic performance and expectations. This study aims to assess differences in h-index related to both gender and rurality among Australian urologists.
    METHODS: We identified all active, practicing Australian urologists through the Urological Society of Australia and New Zealand (USANZ) membership database. Data on each practitioner's gender, subspecialty, academic rank or affiliation, seniority, and h-index from the Web of Science were collected. Differences in h-index by gender and rurality were analyzed using univariable and multivariable regression.
    RESULTS: A total of 463 Australian urologists were included, of whom 69 (14.9%) were female and 73 (15.8%) practiced in rural areas. Female urologists were less likely to hold an academic position of Associate Professor or Professor compared to their male counterparts (5.8% vs. 11.0%, P = 0.28). The average h-index for female urologists was 39% lower than male urologists (univariable P < 0.001). Adjusting for demographic variables, h-index remained 32% lower (multivariable P = 0.003). The average h-index of rural urologists was 51% lower than their metropolitan colleagues (univariable P < 0.001); and after adjusting for demographics, the average h-index was 30% lower (multivariable P = 0.006).
    CONCLUSION: Female and rural urologists in Australia produce significantly less research than their male and metropolitan counterparts. To address this disparity, it is crucial to implement enhanced institutional academic support, targeted mentorship, and greater recognition of the challenges posed by caregiving responsibilities and rural practice.
    Keywords:  Australia; academic surgery; gender equity; h‐index; rural urology; urology; women in surgery
    DOI:  https://doi.org/10.1111/ans.19397
  80. Front Med (Lausanne). 2024 ;11 1507313
    Advances in genetic diagnosis and therapy of hereditary heart disease: a bibliometric review from 2004 to 2024.
    Huixi Ma, Yun Wang, Yang Jia, Linjun Xie, Lini Liu, Dingyi Zhang, Xinyue Ma, Yingkun Guo, Rong Xu.
      Hereditary heart disease (HHD) is a series of cardiac disorders associated with monogenic or polygenic abnormalities and is one of the leading causes of sudden death, particularly in young adults. The updated European Cardiology guideline for cardiomyopathies provides the first comprehensive summary of genotyping, imaging, and therapy recommendations for inherited cardiomyopathies, but still lacks a comprehensive discussion of research advances and future trends in genetic diagnosis and therapy of HHD. Our research aims to fill this gap. Bibliometric analysis software (CiteSpace 6.3.R1, VOSviewer 1.6.18, and Scimago Graphica) was used to analyze the general information, trends, and emerging foci of HHD in the past 20 years, including author, country, institution, keyword, and so on. There were 5,757 publications were screened and aggregated in the database, including 1876 reviews and 3,881 articles. Hypertrophic cardiomyopathy (HCM), arrhythmogenic cardiomyopathy (ACM), Brugada syndrome (BrS), myocardial amyloidosis, and Fabry disease (FD) were the main types of HHD that were explored in greater depth. Moreover, new diagnostic methods, clinical cohorts, and genetically targeted therapies for HHD patients are key research hotspots. The relationship between the pathogenicity of genes and prognosis will become increasingly important for therapy.
    Keywords:  cardiac death; cardiomyopathy; genetic diagnostic; hereditary heart disease; scientometrics
    DOI:  https://doi.org/10.3389/fmed.2024.1507313
  81. Front Med (Lausanne). 2024 ;11 1484097
    Bibliometric mapping of mesenchymal stem cell therapy for bone regeneration from 2013 to 2023.
    Qianqian Chen, Yiqi Su, Zhen Yang, Qiyuan Lin, Yan Ke, Dan Xing, Hui Li.
      Mesenchymal stem cells (MSCs) have shown significant potential in bone regeneration and regenerative medicine in recent years. With the advancement of tissue engineering, MSCs have been increasingly applied in bone repair and regeneration, and their clinical application potential has grown through interdisciplinary approaches involving biomaterials and genetic engineering. However, there is a lack of systematic reviews summarizing their applications in bone regeneration. To address this gap, we analyzed the latest research on MSCs for bone regeneration published from 2013 to 2023. Using the Web of Science Core Collection, we conducted a literature search in December 2024 and employed bibliometric tools like CiteSpace and VOSviewer for a comprehensive analysis of the key research trends. Our findings focus on the development of cell engineering, highlighting the advantages, limitations, and future prospects of MSC applications in bone regeneration. These insights aim to enhance understanding of MSC-based bone regeneration, inspire new research directions, and facilitate the clinical translation of MSC research.
    Keywords:  CiteSpace; VOSviewer; bone regeneration; cell therapy; mesenchymal stem cell; visualization research
    DOI:  https://doi.org/10.3389/fmed.2024.1484097
  82. ACS Omega. 2025 Jan 14. 10(1): 1207-1225
    Global Advancements in Bioactive Material Manufacturing for Drug Delivery: A Comprehensive Study.
    Rafael Leandro Fernandes Melo, Dayana Nascimento Dari, Francisco Izaias da Silva Aires, Francisco Simão Neto, Tiago Melo Freire, Bruno Caio Chaves Fernandes, Pierre Basílio Almeida Fechine, João Maria Soares, José Cleiton Sousa Dos Santos.
      Manufacturing bioactive materials for drug delivery involves developing materials that interact with biological tissues to release drugs in a controlled and targeted manner. The goal is to optimize therapeutic efficacy and reduce side effects by combining knowledge from materials engineering, biology, and pharmacology. This study presents a detailed bibliometric analysis, exploring the keywords "manufacturing," "bioactive materials," and "drug delivery" to identify and highlight significant advancements in the field. From the Web of Science, 36,504 articles were analyzed, with 171 selected for a deeper analysis, identifying key journals, countries, institutions, and authors. The results highlight the field's interdisciplinary nature, with keywords grouped into four main themes, including regenerative medicine, scaffolds, three-dimensional (3D) printing, bioactive glass, and tissue engineering. Future research in this area will focus on more effective and precise systems using technologies like 3D printing and nanotechnology to enhance the customization and control of drug release, aiming for more efficient and targeted therapies.
    DOI:  https://doi.org/10.1021/acsomega.4c08669
  83. Aesthetic Plast Surg. 2025 Jan 22.
    Global Trends in Aesthetic Plastic Surgery Clinical Trials: A Visualization and Bibliometric Analysis (2004-2023).
    Sa'ed H Zyoud, Sari Taha, Faris Abushamma.
      Level of Evidence V This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors  www.springer.com/00266 .
    DOI:  https://doi.org/10.1007/s00266-025-04676-4
  84. Head Neck. 2025 Jan 21.
    Female Representation Among Head and Neck Surgical Oncology Publications.
    Monica S Trent, Madelyn Frank, Leo L T Meller, Daniella Chan, Cynthia Tsang, Waheda Tokhi, Tjoson Tjoa, Yarah M Haidar.
       BACKGROUND: There is lower female representation within academic medicine. We aimed to investigate female authorship (FA) and female-held chair or program director (PD) positions within head and neck oncology (HNO).
    METHODS: Articles authored by females about microvascular and reconstructive surgery (MRS) and transoral robotic surgery (TORS) were identified. A sub-analysis was performed by investigating the gender of HNO fellows, PDs, and chairpersons. These were collected, and FA reported.
    RESULTS: There were 1227 publications, 656 on MRS and 567 on TORS. Females authored 299 (24%) publications, 139 (23%) about MRS and 160 (30%) about TORS. There was no significant increase in FA or fellowship trends over time (p > 0.05). In our sub-analysis, we identified four HNO chairwomen (3%), and eight (6%) female HNO PDs. HNO chairwomen authored an average of 97 publications, PDs authored 37.
    CONCLUSION: FA in MRS and TORS remained stable between 2001 and 2022. Although few HNO females hold program chair or PD positions they perform quality research and serve as senior authors on a large proportion of publications.
    Keywords:  academic medicine; authorship; gender representation; microvascular reconstruction; transoral robotic surgery
    DOI:  https://doi.org/10.1002/hed.28066
  85. Laryngorhinootologie. 2025 Jan 21.
    [Gender differences in scientific publications].
    Julia Esser, Shachi Jenny Sharma, Stefanie Jansen, Marcel Mayer, Louis Jansen, Jens Peter Klußmann, Jan Christoffer Lüers.
      The aim of this study was to investigate the representation of women in the German-speaking scientific publication landscape of otorhinolaryngology.Authorship was analyzed based on articles published between 2013 and 2023 in the two largest otorhinolaryngology journals (Laryngorhinootologie, HNO) to determine the frequency and percentage of gender distribution among first and last authorships.A total of 2,631 articles were examined. Women were first authors in 699 articles (26.6%) and last authors in 384 articles (14.6%). Clear trends indicating an increase in the proportion of women were observed: First-author publications rose from 19.9% to 34.5% over the analyzed 10-year period, while last-author publications increased from 9.4% to 19.0%.The proportion of women publishing as first or last authors in otorhinolaryngology is rising but remains low. Efforts to promote gender diversity could further increase the proportion of women among the authors in otorhinolaryngology literature.
    DOI:  https://doi.org/10.1055/a-2513-6647
  86. Talanta. 2025 Jan 13. pii: S0039-9140(25)00078-5. [Epub ahead of print]287 127592
    Advancements and prospects of molecularly imprinted polymers as chemical sensors: A comprehensive review.
    Riyadh Abdulmalek Hassan, Sharina Abu Hanifah, Lee Yook Heng.
      The scientific literature on molecularly imprinted polymers (MIPs) has grown significantly in the past decades, reflecting an increasing interest in their potential applications. MIPs are valued for their ability to selectively detect a broad range of analytes and mimic biological recognition in different environmental conditions. This review utilises data (Scopus data from 2010 to 2024) from a bibliometric visualisation with VOSviewer (version 1.6.2) to identify trends and research hotspots in developing MIP-based sensors. The findings from this review indicated notable advancements in molecular imprinting technology (MIT) and the challenges MIP technology faces. It also discusses how various optimisation preparation techniques can be used to overcome the inherent limitations of MIP synthesis. The review also presents a case investigation and suggests classifying MIPs as chemosensors (chemical sensors) rather than biosensors to resolve the confusion and classification difficulties encountered in the existing literature on MIP sensors. It also addresses critical issues regarding the paradoxical lack of MIP-based sensors in the commercial market despite a marked increase in scientific output. The review outlines future research directions to enhance MIP sensor technology further. It emphasises the need for more collaboration between academia and industry to bridge existing gaps and accelerate commercialisation.
    Keywords:  Bibliometric analysis; Chemical sensors; Molecularly imprinted polymers (MIPs); Research trends; Visualisation networks
    DOI:  https://doi.org/10.1016/j.talanta.2025.127592
  87. F1000Res. 2024 ;13 421
    A bibliometric review of functional ingredients and their efficacy in developing functional biscuits.
    Kshama Vishwakarma, Varalakshmi Chandra Sekaran, Vidya Patwardhan, Asha Kamath.
       Introduction: Numerous studies have concluded that the functional ingredients benefit human health. Similarly, present times have seen exponential growth in functional food in bakery product segments like breads and biscuits. However, there is a lack of information on functional ingredients and their usefulness in developing functional bakery products. This bibliometric study addresses this gap by identifying the current research trends in functional ingredients.
    Objective: To investigate current research trends on functional ingredients and their usefulness in developing functional biscuits.
    Method: The study followed the "Scientific Procedures and Rationales for Systematic Literature Reviews" standards for retrieving literature. The study went through three major stages, "assembling", "arranging", and "assessing" to retrieve 612 articles from the Scopus database from 2013 to 2023. Through further filtering, 395 articles were selected.
    Result: The analysis was conducted using R Studio and VOS viewer. The performance analysis and science mapping tools were used to evaluate the articles. The results showed a 5.76% annual growth in publication trends. The most researched functional ingredients were antioxidants, bioactive compounds, and dietary fiber. The review summarized the most studied foods used to develop functional biscuits and highlighted the most experimented technological advancements.
    Conclusion: The study revealed the need for future research studies on functional ingredients with a focus on studying the implications of technical implications of technical advancements in extracting functional ingredients from foods. The study highlights the significance of future studies based on the acceptance of functional biscuits and their sensory properties focusing on the mass population. The study derives the knowledge on possible applicability of functional ingredients in developing new formulations from publications and their usefulness in developing new formulations. This insight on the applicability of functional ingredients provides an opportunity for biscuit/cookie manufacturing to boost consumption among the population to a new ascending graph.
    Keywords:  “Antioxidants” “Functional ingredients”; “Dietary fibers”; “Functional biscuits/cookies”; “Phenolic compounds”
    DOI:  https://doi.org/10.12688/f1000research.148029.2
  88. Pediatr Radiol. 2025 Jan 22.
    The publication fate of abstracts awarded prizes at European Society of Paediatric Radiology annual scientific meetings.
    ESPR Publications Committee (consortium)
       BACKGROUND: The European Society of Paediatric Radiology (ESPR) awards prizes for outstanding work presented at their annual scientific meetings. The proportion of ESPR prize-winning abstracts to journal publications is not known. Contextualising abstract-to-publication proportions by evaluating publication experience can yield valuable insights and actionable outcomes to support researchers in overcoming barriers to journal publication.
    OBJECTIVE: To assess the abstract-to-publication proportion of prize-winning ESPR abstracts and prize-winning authors' experience of publishing in Pediatric Radiology, the affiliated journal of the ESPR and other specialist international paediatric radiology societies.
    MATERIALS AND METHODS: PubMed was searched for titles of ESPR prize-winning abstracts from 1977 (the year of first award) up to and including 2021, where the presenter was either first or co-author, and the article was published 2 years before or after the presentation year. If not found, a general internet search was performed. Titles of all retrieved articles were evaluated for inclusion. A survey was distributed to all ESPR prize winners to better understand their experiences around journal submission.
    RESULTS: Over 44 years, 108 prizes were awarded. The prize-winning abstract-to-publication proportion was significantly higher (59.3%, OR=2.10, P=0.012) than the recently published pediatric radiology "abstract to publication rate" (41.9% from 2013-2016). Moreover, prize winners were more than twice as likely than to achieve journal publication (OR=2.10), and as first author (OR=1.33). The majority of awardees published their work as first author (52/64, 81.3%): the first-author abstract-to-publication proportion was not significantly higher than the paediatric radiology "abstract-to-publication rate" (48.1%, OR=0.33, P=0.330). Sixty-four survey responses were received (59.3%, out of a total 108 awarded prizes). Just over 20% of prize-winning work was published in Pediatric Radiology, with 41.5% of respondents reporting a good to excellent submission experience.
    CONCLUSION: Prize-winning and first-author abstract-to-publication proportions are higher for ESPR-awarded abstracts than the most recently reported paediatric radiology "abstract-to-publication rate", suggesting that prizes are either awarded to work most likely to be published or that being awarded a prize encourages publication. Given that just over 40% of prize-winning abstracts remain unpublished, the ESPR should do more to support and encourage all authors to publish their work.
    Keywords:  Abstracts; Conferences and congresses; Medical societies; Paediatric; Publications; Radiology
    DOI:  https://doi.org/10.1007/s00247-024-06152-8
  89. Ann Plast Surg. 2025 Feb 01. 94(2): 212-216
    The Impact of International Fellowship on Research Productivity: International Fellowship on Research Productivity.
    Andrew J James, Yomna E Dean, Benjamin L Savitz, Lauren E Sullivan, Mariam Saad, Ricardo A Torres-Guzman, Erin N Abbott, Ronald M Cornely, Barite W Gutama, Noah E Alter, Panambur L Bhandari.
       ABSTRACT: International medical graduates (IMGs) represent a significant portion of the US physician workforce, comprising 25% across all specialties with a strong presence in internal medicine and primary care. However, their representation in plastic surgery remains limited at only 10%. Matching into a US plastic surgery residency is highly competitive for both US medical graduates and IMGs. This study aimed to quantify and identify trends in academic contributions from IMGs applicants in a plastic surgery residency program over the past 13 years, hypothesizing that IMG applicants have increasingly contributed to collaborative research projects.Data from National Resident Matching Program annual reports were analyzed, focusing on publications, research experience, and match status. An analysis of variance revealed significant differences between US MDs and IMGs in terms of publications and research experience. IMGs had a higher number of publications and work experience compared to matched US MDs, while US MDs had more research experiences than IMGs.The findings underscore the importance of research for IMGs, who often engage in additional research experiences to enhance their competitiveness for residency positions. The study showed that IMGs have a greater research output, contributing significantly to academic publications within the plastic surgery field. This productivity benefits the IMGs in securing residency positions and enriches the academic research environment of the residency programs.IMGs bring unique perspectives and innovative approaches to research, often collaborating internationally, which enhances the scope and quality of research projects. Their contributions are vital to the advancement of plastic surgery and the broader medical field. As the demand for physicians in the US grows, integrating IMGs into the healthcare system through strategic inclusion in research and clinical training is essential. This study highlights the critical role of IMGs in driving medical research and underscores the need for supportive policies to facilitate their integration into the US healthcare workforce.
    DOI:  https://doi.org/10.1097/SAP.0000000000004220
  90. Muscle Nerve. 2025 Jan 20.
    Are Women Physicians Underrecognized for National Awards in Neuromuscular and Electrodiagnostic Medicine? An Observational Study.
    Emma A Ali Bateman, Caitlin Cassidy, Rachel Reardon, Jamie L Fleet.
       INTRODUCTION/AIMS: Institutions and organizations, including the American Association of Neuromuscular and Electrodiagnostic Medicine (AANEM), have committed to embracing principles of equity, diversity, and inclusion. Notwithstanding this commitment, studies repeatedly demonstrate that women physicians are less likely to receive awards in medicine and research compared to their male counterparts. Whether women physicians are less likely to be recognized with AANEM awards is unknown. The objective of this study was to evaluate whether there is a gender disparity in the AANEM's annual awards.
    METHODS: In this retrospective observational study, lists of award winners were obtained from the AANEM website. Award winners' gender was assigned by three independent reviewers based on searches of public professional websites according to established methodology. Data were analyzed using descriptive statistics.
    RESULTS: Of 154 physician awards from 1957 to 2023, 24 (15.6%) were awarded to women and 135 (84.4%) to men. The first woman to win an AANEM award was in 2003. As the number of award categories increased over time (from 1 pre-1994 to 9 as of 2019), so too did the proportion of women winners. From 1994 to 2003, 3.4% of AANEM awardees were women compared to 17.1% from 2004 to 2013 and 18% from 2014 to 2023. Even over time, the greatest disparities existed for the Distinguished Physician/Researcher and Lifetime Achievement awards.
    DISCUSSION: For the AANEM, there is a notable gender gap in physician awards, but this gap has narrowed over time. Further efforts to address systemic barriers contributing to this disparity are warranted.
    Keywords:  United States; awards and prizes; electromyography; gender equity; medical societies
    DOI:  https://doi.org/10.1002/mus.28350
  91. Am J Public Health. 2025 Jan 23. e1-e13
    Research Funded by National Institutes of Health Concerning Sexual and Gender Minoritized Populations: A Tracking Update for 2012 to 2022.
    Ben C D Weideman, Alexandra M Ecklund, Rhea Alley, B R Simon Rosser, G Nic Rider.
      Objectives. To investigate trends in awards funded by the National Institutes of Health (NIH) focusing on sexual and gender minoritized (SGM) populations from 2012 to 2022 in the United States. Methods. Replicating the method of Coulter et al., we identified NIH-funded awards for SGM research from 2012 to 2022 using the NIH RePORTER (Research Portfolio Online Reporting Tools Expenditures and Results) system. We coded for SGM subpopulations, demographics, and health content areas. We also inflation adjusted awards to 2022 dollar values. Results. NIH funded 1093 unique awards concerning SGM health, which totaled $491.7 million in first-year funding and made up 0.8% of the NIH portfolio. Frequency of awards nearly tripled over our study period. Most awards focused on HIV/AIDS (65.5%), mental health (29.5%), illicit drug use (19.9%), or sexual health issues (17.0%). We found funding differences across subpopulations: sexually minoritized men (67.8%; $357.9 million), transgender women (18.1%; $77.6 million), sexually minoritized women (13.9%; $57.6 million), transgender men (8.2%; $37.6 million), and nonbinary people (4.4%; $17.6 million). Only 42.2% of awards explicitly examined racial/ethnic identities of participants. Conclusions. Although NIH funding for SGM-related research has increased, persistent inequities indicate the need for systemic changes to advance health equity. (Am J Public Health. Published online ahead of print January 23, 2025:e1-e13. https://doi.org/10.2105/AJPH.2024.307913).
    DOI:  https://doi.org/10.2105/AJPH.2024.307913
  92. Proc Natl Acad Sci U S A. 2025 Jan 28. 122(4): e2402053122
    Postdoc publications and citations link to academic retention and faculty success.
    Yueran Duan, Shahan Ali Memon, Bedoor AlShebli, Qing Guan, Petter Holme, Talal Rahwan.
      Postdoctoral training is a career stage often described as a demanding and anxiety-laden time when many promising PhDs see their academic dreams slip away due to circumstances beyond their control. We use a unique dataset of academic publishing and careers to chart the more or less successful postdoctoral paths. We build a measure of academic success on the citation patterns two to five years into a faculty career. Then, we monitor how students' postdoc positions-in terms of relocation, change of topic, and early well-cited papers-relate to their early-career success. One key finding is that the postdoc period seems more important than the doctoral training to achieve this form of success. This is especially interesting in light of the many studies of academic faculty hiring that link Ph.D. granting institutions and hires, omitting the postdoc stage. Another group of findings can be summarized as a Goldilocks principle: It seems beneficial to change one's direction, but not too much.
    Keywords:  careers; postdoctoral training; science of science
    DOI:  https://doi.org/10.1073/pnas.2402053122
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