bims-evares Biomed News
on Evaluation of research
Issue of 2025–06–22
95 papers selected by
Thomas Krichel, Open Library Society
  1. Advancements and Trends in Electrochemical Biosensors for Saliva-Based Diagnosis of Oral Diseases: A Bibliometric Analysis (2000-2023).
  2. AO Spine Knowledge Forums Promote Collaboration and Elevate the Impact of Research: A Bibliometric Analysis.
  3. Knowledge Mapping of intracranial artery dissection: A Bibliometric Analysis (2014-2024).
  4. Exploration of the current status and trends of pancreatic cancer immune cells in the past 30 years: a bibliometric analysis.
  5. Areas of research focus and trends in the research on the application of AIGC in healthcare.
  6. Bibliometric and visualization analysis of temporomandibular joint osteoarthritis from 2004 to 2024.
  7. Bibliometric analysis of resilience in stroke from 2000 to 2024 using CiteSpace and VOSviewer.
  8. A Bibliometric Analysis of Neuroinflammation in Depression from 2004 to 2023: Global Research Hotspots and Prospects.
  9. Laparoscopic surgical robotics (1999-2023): a bibliometric exploration of technological evolution and research frontiers.
  10. Making Sense of Proprioception by Bibliometric Research.
  11. Global insights and knowledge mapping of immunity and inflammation in acute pancreatitis: A bibliometric and visual analysis.
  12. A bibliometric analysis of wearable device research in sleep science: Trends and hotspots.
  13. Decoding the gut-sleep Nexus: a bibliometric mapping of gut microbiota and sleep disorders.
  14. A bibliometric analysis of research trends in mesenchymal stem cell therapy for neonatal bronchopulmonary dysplasia: 2004-2024.
  15. Mapping the Nursing Literature on Postoperative Pain: A Bibliometric Analysis.
  16. Bibliometric Analysis of 25 Years of Emergency Medicine Research in Latin America.
  17. Research progress in intracranial artery dissections over past 25 years: a review and bibliometric analysis.
  18. Visualization of research trend of neoadjuvant chemotherapy for breast cancer treatment: a bibliometric analysis.
  19. Research trends and hotspots in viral neglected tropical diseases: a bibliometric analysis.
  20. Global Research Trends in Pediatric Acute Respiratory Distress Syndrome: A Bibliometric Analysis from 2014 To 2024.
  21. Electrophysiology in neuropathic pain: a bibliometric analysis and literature review.
  22. Tracheostomy in COVID-19 critically ill patients: a bibliometric and visual analysis.
  23. Mapping key trends, relationships, and molecular pathways for neuroprotection in glaucoma: a bibliometric approach.
  24. Current status, hotspots and frontiers of ion channel-related research in glioblastoma: a bibliometric analysis from 2005 to 2024.
  25. Emerging trends of the tumor microenvironment in peritoneal malignancies (2010-2024): a visualization analysis.
  26. Global Trends in Hepatocellular Carcinoma and TGF-β Research: A Bibliometric and Visualization Analysis from 2000 to 2024.
  27. Understanding Research Trends in Facial Synkinesis: A Bibliometric Analysis of the 100 Most Impactful Studies.
  28. Global trends and research hotspots in the treatment of mental disorders with transcranial magnetic stimulation: a bibliometric analysis.
  29. Bibliometric and visualized analysis of global distribution and research frontiers in tumor immune escape.
  30. Research Trends and Hotspots in Postoperative Pain and Nursing: A Bibliometric Analysis.
  31. Bibliometric analysis of global research on PD-L1/PD-1 pathway and neurodegenerative diseases over the last two decades (2004-2023).
  32. Artificial intelligence in endoscopy and colonoscopy: a comprehensive bibliometric analysis of global research trends.
  33. Frontier and hotspot evolution in pulmonary embolism: A bibliometric analysis from 2004 to 2023.
  34. Bibliometric analysis of research trends on hyperbaric oxygen therapy in stroke from 2000 to 2022.
  35. Smoking and bladder cancer: insights into pathogenesis and public health implications from a bibliometric analysis (1999-2023).
  36. Characterization of Global Research Trends and Prospects on Prone Positioning in Respiratory Failure: Bibliometric Analysis.
  37. Tracing inflammasomes in Alzheimer's: insights from bibliometric analysis.
  38. Global research trends in minimally invasive treatments for kidney stones: A bibliometric analysis (2015-2024).
  39. A Bibliometric Analysis of Research Trends in Spousal Support for Breast Cancer Patients.
  40. Lower-limb locomotor function studies using walking speed as an assessment indicator: A bibliometric review from 2014 to 2024.
  41. A bibliometric analysis of challenges and advancements in the integrated application of nanoparticles and chimeric antigen receptor T cell therapy.
  42. Emerging trends in anticoagulation therapy: a bibliometric analysis of DOACs and endogenous coagulation pathway inhibitors.
  43. The evolution of digital health: a global, Latin American, and Brazilian bibliometric analysis.
  44. Comprehensive bibliometric and visualized analysis of research on incisional hernia and component separation from 1996 to 2023.
  45. Digital horizons in non-communicable disease care: a bibliometric exploration of intervention impact and innovation.
  46. COVID-19's impact on heart and lung transplantation: Citation-based analysis of research output.
  47. Research focus and trends of the association between gut microbiota and neuroinflammation.
  48. Exploring the growth and impact of artificial intelligence in anesthesiology: a bibliometric study from 2004 to 2024.
  49. Publication trends and hotspots for cervical cancer screening biomarker: a bibliometric analysis.
  50. A Descriptive Bibliometric Study of CERA Publication Dissemination, Authorship, and Citation Rates.
  51. Bacillus cereus in food safety: a bibliometric analysis.
  52. Unveiling the role of NAD glycohydrolase CD38 in aging and age-related diseases: insights from bibliometric analysis and comprehensive review.
  53. Research hotspots and trends on illicit drugs: a bibliometric and visualized analysis.
  54. Global Research Trends in Oxidative Stress and Myocardial Fibrosis: A Dual-Software Bibliometric Study.
  55. From conference to journal: Analyzing the path to publication for EUGA and JOGS 2022 abstracts.
  56. Bibliometric analysis of the interplay between Alzheimer's disease and type 2 diabetes mellitus: Trends, hotspots, and emerging research areas.
  57. Comprehensive Bibliometric Analysis of Prediction Models for HCC: Current Trends and Future Prospects.
  58. A scientometric analysis of biochar applications for soil remediation in mining-affected environments: research trends, intellectual structure, and emerging themes.
  59. Executive functions in children with ADHD: A comprehensive bibliometric analysis.
  60. The role of antioxidant therapy in modulating neuropathic pain: A systematic review of mechanistic insights and research trends (2003-2024).
  61. State family support policies and their impact on women's representation and productivity in surgical research: A web-scraping comparative analysis.
  62. Two Decades of Gender Differences in Pornography Research Topics.
  63. Multidisciplinary Contributions and Research Trends in eHealth Scholarship (2000-2024): Bibliometric Analysis.
  64. Gender representation in professorship and research productivity across all surgical specialties in Canadian academic institutions.
  65. Two decades of progress in gastric cancer peritoneal metastasis: a bibliometric perspective on molecular mechanisms and therapeutic innovations.
  66. Impact of 11 years of glaucoma research funding: Glaucoma Research Society of Canada (2010-2020).
  67. What we know and what should we know about the future of blockchain in finance.
  68. Bridging the Gap: The State of Global Transplant Research Collaboration.
  69. Global research trends on Chinese patent drugs inducing programmed cell death in cancer: a bibliometric analysis (1998-2024).
  70. From Androgen Deprivation to Precision Therapy: A Bibliometric Review of Global Research Trends (2008-2023).
  71. Retraction notice to "The bibliometric analysis of previous twenty-five years' literature: A microfinance review" [Heliyon 10 (2024) e24979].
  72. Utilizing Altmetrics to Track Advancements in Noninvasive Tests for MASLD.
  73. Impact Factor Trends of Top Obstetrics and Gynecology Journals During COVID-19.
  74. Suicidology Needs a More Inclusive Approach for Low and Middle-Income Countries.
  75. Mapping the knowledge of epilepsy and Potassium Channels: A scientometric analysis in CiteSpace and VOSviewer.
  76. The research trends and hotspots of claudins in the field of cancer.
  77. The adverse events of toripalimab in nasopharyngeal carcinoma based on FAERS database and bibliometric analysis.
  78. 2009-2023 Bibliometric analysis of the clinical value of graphene quantum dots in glioblastoma treatment.
  79. Gender equality in leadership of HIV care cascade clinical trials: A methodological study.
  80. [Visual analysis of the research status and trends in acupuncture and moxibustion treatment for respiratory diseases in the past decade].
  81. Systematic evaluation of the associations between schizophrenia and autoimmune diseases: An umbrella review.
  82. Managerial Challenges in Digital Health: Bibliometric and Network Analysis.
  83. A critical review of microplastics and nanoplastics in wastewater: Insights into adsorbent-based remediation strategies.
  84. Health Emergency Research Preparedness: An Analysis of National Pre‑COVID Research Activity and COVID Research Output.
  85. [Analysis of dissertations on forensic medicine devoted to medical errors in cases of improper healthcare delivery over a 15-year period (2009-2023)].
  86. Evaluation of Sex Specific Representation and Sex Disaggregated Reporting in European Society for Vascular Surgery 2024 Clinical Practice Guidelines on the Management of Abdominal Aorto-iliac Artery Aneurysms.
  87. Female Authorship Trends in Ophthalmology Glaucoma.
  88. Erratum: Editor Note to "From theory to practice: Revealing the real-world impact of cognitive behavioral therapy in psychological disorders through a dynamic bibliometric and survey study".
  89. Analyzing collaboration dynamics in new drug R&D: A case study of two lipid-lowering drugs.
  90. A multidimensional research productivity dataset of 21st-century Nobel Laureates in physiology or medicine.
  91. A Seven-Decade Analysis: What Does the Gender Breakdown of Award Recipients in the All India Ophthalmological Society Reveal?
  92. Snapshots: most-cited Primates papers by decade (1950s-2020s).
  93. Exploring research knowledge and interests among Argentinian orthopedic trauma surgeons: a survey-based study to implement strategic tools for curricular development GAIA (Group for Support of Argentine Research).
  94. PubMed knowledge graph 2.0: Connecting papers, patents, and clinical trials in biomedical science.
  95. Correction to: Knowledge mapping on the sun‑induced chlorophyll fluorescence technology research: a scientometric and visualization analysis.
  1. Int Dent J. 2025 Jun 12. pii: S0020-6539(25)00129-7. [Epub ahead of print]75(4): 100840
    Advancements and Trends in Electrochemical Biosensors for Saliva-Based Diagnosis of Oral Diseases: A Bibliometric Analysis (2000-2023).
    Qian Tang, Fushen Zhang, Weiye Xu, Zejun Deng, Zhangui Tang, Jufang Huang.
       BACKGROUND: Oral diseases, such as dental caries, periodontal diseases, and oral cancers, represent significant global public health challenges. With the COVID-19 pandemic, traditional diagnostic methods have limitations, thus highlighting the need for innovative, early, and non-invasive diagnostic approaches. Analyse and summarise publications globally through a comprehensive bibliometric study to help researchers suggest possible directions for future research.
    OBJECTIVE: The purpose of the study was to evaluate global academic productivity, impact, and collaboration of electrochemical biosensors for oral diseases utilising bibliometrics based on annual number of publications, countries and regions, institution, authors, journals, citations and co-occurrences of author keywords over the last 20 years.
    METHODS: This study employs bibliometric analysis to assess the research of electrochemical biosensors for oral diseases in the Web of Science from 2000 to 2023. Utilising VOSviewer, CiteSpace software, and Microsoft Excel, we conducted a bibliometric and visualised analysis of electrochemical biosensors for oral diseases.
    RESULTS: The quantity of pertinent publications in this research domain displays a fluctuating but overall upward trend. In aggregate, there are 341 articles and 82 reviews, encompassing research contributions from 55 countries, 649 institutions, and involving 2068 authors. Among these publications, China, the USA, and India emerged as the predominant contributing nations. Predominantly, articles found their publication venue in "Biosensors & Bioelectronics." Notably, the author with the highest number of publications and most influence is Wang, Joseph S. The top 3 keywords include "biosensor,""sensor,""saliva."
    CONCLUSION: In this investigation, statistical analysis and network visualisation were conducted to reveal the research progress, trends, and trending topics on electrochemical biosensors for oral diseases via a thorough bibliometric analysis. We found that Despite these challenges, electrochemical biosensors hold significant promise for transforming oral disease diagnostics. Overcoming current technical barriers will improve both oral and systemic health outcomes.
    Keywords:  Bibliometrics; Biomarkers; Electrochemical biosensors; Saliva; oral diseases
    DOI:  https://doi.org/10.1016/j.identj.2025.100840
  2. Global Spine J. 2025 Jun 13. 21925682251351012
    AO Spine Knowledge Forums Promote Collaboration and Elevate the Impact of Research: A Bibliometric Analysis.
    Daniel N de Souza, David B Kurland, Luiz Vialle, Klaus J Schnake, Shekar N Kurpad, Stephen J Lewis, Gregory D Schroeder, Sangwook T Yoon, Stefano Boriani, Ziya Gokaslan, Laurence D Rhines, Arjun Sahgal, Charles Fisher, Ilya Laufer.
      Study DesignBibliometric analysis.ObjectivesThis study used bibliometric analyses to characterize the effect of AO Spine Knowledge Forum (KF) participation on publication trends among members. We examined associations of membership in KF organizations with academic productivity, collaboration, and scientific impact.MethodsWe queried the Web of Science database for publications by members of KF Tumor (N = 58), KF Trauma and Infection (N = 45), KF Spinal Cord Injury (N = 38), KF Degenerative (N = 54), and KF Deformity (N = 55). Resulting metadata were exported; statistical and bibliometric analyses were performed using Python packages.ResultsOur query returned 24,267 articles by KF members, of which 18,804 were identified as relevant to respective organizational themes through an algorithmic analysis of titles and abstracts. These works, published between 1980 and 2025, included contributions from 67,895 authors. Research productivity, co-authorship among members (P < 0.001), unique institutional affiliations per article (P < 0.001), and international collaboration increased contemporaneously with the first KF formation (2010). A positive association was found between the number of KF authors per publication and source journal impact factor (P < 0.001). Term analysis highlighted research foci within each KF and influential publications were identified.ConclusionsThese findings suggest that formalization of researcher relationships and the research infrastructure and support provided by the KF model was associated with increased and more impactful research output and collaboration. The KF model could be applied in other organizations whose mission includes collaborative research. Methods used in this study are easily replicable and may be applied to investigate the impact of other professional organizations across various fields.
    Keywords:  AO spine; bibliometrics; knowledge forum; professional organization; research; spine
    DOI:  https://doi.org/10.1177/21925682251351012
  3. World Neurosurg. 2025 Jun 11. pii: S1878-8750(25)00528-5. [Epub ahead of print] 124172
    Knowledge Mapping of intracranial artery dissection: A Bibliometric Analysis (2014-2024).
    Yonghong Wang, Wei Pan, Yuhua Peng, Shulai Zhu.
       METHOD: Articles about intracranial arterial dissection published from 2014 to 2024 were retrieved from the Web of Science Core Collection (WoSCC) database. VOSviewer, CiteSpace, and Microsoft Excel were employed for bibliometric analysis.
    RESULTS: In total, 943 articles from 67 countries and 1448 institutions were included, with a particular focus on the United States and China. The number of publications showed an overall incremental trend, peaking in 2020. Capital Medical University, Mayo Clinic, Pusan National University, and University of California, San Francisco were the main research institutions. "World Neurosurgery" was the most popular journal in this field, while "Stroke" was the most commonly cited journal. Lawton Michael, Lanzino Giuseppe, and Yang Xinjian possessed the highest number of publications, with Debette being the most frequently cited author. "Dissection" and "stroke" were the most common keywords. Studies mainly focused on imaging-based diagnosis, vascular diseases, treatments, and complications. "Large vessel occlusion", "outcome", and "prevalence" were recent research hot topics.
    CONCLUSION: This is the first bibliometric study that comprehensively summarizes the research trends in the field of intracranial artery dissection (IAD). We identified recent research frontiers and hot topics, providing a reference for researchers focusing on this field.
    Keywords:  Bibliometrics; CiteSpace; Intracranial arterial dissection; VOSviewer
    DOI:  https://doi.org/10.1016/j.wneu.2025.124172
  4. Discov Oncol. 2025 Jun 14. 16(1): 1105
    Exploration of the current status and trends of pancreatic cancer immune cells in the past 30 years: a bibliometric analysis.
    Yang Hu, Simeng Lei, Zihan Zhang, Kexin Wang, Zhili Ji.
       OBJECTIVE: Immune cells are pivotal in progressing and treating pancreatic cancer. Over the past three decades, the complex interactions between pancreatic cancer and immune cells have garnered much attention, as evidenced by the increasing number of publications in this domain. This bibliometric study maps the global research landscape of pancreatic cancer immune cell interactions, emphasizing evolving trends, collaborative networks, and therapeutic innovation.
    METHOD: Using VOSviewer and CiteSpace, we analyzed 2658 articles from the Web of Science Core Collection (2000-2024) to evaluate publication trends, collaborative networks, keyword dynamics, and highly cited works.
    RESULTS: Annual publications surged from 4 (2000) to 453 (2024), with China (44.9%) and the U.S. (33.6%) dominating output. Key institutions included Fudan University (102 articles) and Zhejiang University (88 articles). Keyword evolution revealed three phases: antitumor mechanisms, clinical translation of checkpoint inhibitors, and recent emphasis on stromal-immune crosstalk. High-impact works by Brahmer (N Engl J Med 366:2455-2465, 2012) and Marabelle (J Clin Oncol 38:1-10, 2020) underscored immunotherapy milestones.
    CONCLUSION: This bibliometric analysis highlights the dynamic nature of pancreatic cancer immune cell research, emphasizing the growing global interest and investment in this field. The findings underscore the need for ongoing monitoring of research trends to inform and propel innovative therapeutic strategies, ultimately improving patient outcomes.
    Keywords:  Bibliometric analysis; Citespace; Immune cells; Pancreatic cancer; VOSviewer
    DOI:  https://doi.org/10.1007/s12672-025-02886-5
  5. J Health Popul Nutr. 2025 Jun 14. 44(1): 195
    Areas of research focus and trends in the research on the application of AIGC in healthcare.
    Chen Wang, Yingying Zhu, Xuejiao Zhang, Xueqing Chen, Yilin Li, Yongjie Tan, Huiying Qi.
       BACKGROUND: As a crucial part of current AI technology, the extent of AIGC's (Artificial Intelligence Generated Content) impact on healthcare, its potential to further drive the development of intelligent healthcare, and its ability to alleviate the current scarcity of medical resources have become highly discussed topics in academia and the healthcare sector. Our aim is to conduct bibliometric study to analyze and visualize the current research hotspots and trends related to the application of AIGC in healthcare.
    METHODS: Studies related to the application of AIGC in healthcare that were published from November 30 2022, to December 31 2023, were retrieved via the Web of Science Core Collection. CiteSpace and Microsoft Excel were utilized to analyze and visualize the annual publications, countries, institutions, authors, journals, high cited literature and keywords.
    RESULTS: A total of 3411papers were included, and the number of publications is increasing rapidly in recent two years. The United States and Harvard University are respectively the leading country and institution in terms of the number of research publications on the application of AIGC in healthcare. Thongprayoon Charat and Cheungpasitporn Wisit are outstanding investigators in this field. Nature is the most influential journal in the field of AIGC' s application in healthcare, whereas Cureus Journal of Medical Science boasts the highest number of publications on this topic. The analysis of keywords and high cited literature has identified current research hotspots, including the impact exploration of the application of AIGC in the healthcare industry, the assessment of applicability, the perception of healthcare related personnel, and the development of AIGC in the healthcare field.
    CONCLUSIONS: This paper presents a bibliometric analysis of the research framework and hotspots concerning the application of AIGC in healthcare. The analysis aims to provide a comprehensive understanding of this field for researchers. Future research should focus on establishing regulatory mechanism, optimizing healthcare information services, clarifying the role of AIGC, and continuously developing medical large language models.
    Keywords:  AIGC; Bibliometric; ChatGPT; Development trends; Healthcare; Research focuses
    DOI:  https://doi.org/10.1186/s41043-025-00947-7
  6. Front Oral Health. 2025 ;6 1596551
    Bibliometric and visualization analysis of temporomandibular joint osteoarthritis from 2004 to 2024.
    Chi Xu, Chongqing Yu, Tao Wang, Xiang Gao.
       Background: Temporomandibular joint osteoarthritis (TMJOA) is a severe condition affecting the temporomandibular joint, impairing essential oral functions such as chewing, speaking, and swallowing. Recent studies have made significant outcomes in pathogenesis, clinical symptoms, and therapy in the field of TMJOA. However, knowledge of research trends and hotspots of TMJOA is still lacking in this field. This study conducted a bibliometric analysis of TMJOA, providing a comprehensive overview of current research hotspots and trends.
    Methods: A total of 584 TMJOA-related records published between 2004 and 2024 were retrieved from the Web of Science Core Collection (WoSCC) database. VOSviewer, CiteSpace, the R package "bibliometrix", and the Bibliometric website were used to analyze countries, institutions, journals, authors, and keywords to identify research trends in TMJOA.
    Results: Publications on TMJOA have shown a steady annual increase. Globally, China and the USA emerged as the leading contributors, accounting for over 60% of the publications. Sichuan University ranked first in total publications and citations, while the University of Northern Carolina led in average citations. The Journal of Oral Rehabilitation published the most studies, whereas the Journal of Dental Research had the highest impact factor (5.3) and H-index (158). Long X was the most prolific author, while Liu Y, Manfredini D, and Guarda-Narnini L were the top-cited authors with the highest H-indices. Keyword analysis revealed four primary research clusters: "pathogenesis mechanisms", "clinical manifestations", "regeneration research", and "therapy research".
    Conclusion: This bibliometric analysis highlights publication trends, research hotspots, citation patterns, and collaborative networks among countries, institutions, and authors in the TMJOA field. Future research is expected to focus on molecular signaling pathways and targeted therapies for TMJOA, with the ultimate goal of accelerating translational research to enhance clinical outcomes for patients.
    Keywords:  CiteSpace; VOSviewer; bibliometric; osteoarthritis; temporomandibular joint
    DOI:  https://doi.org/10.3389/froh.2025.1596551
  7. Front Psychol. 2025 ;16 1452249
    Bibliometric analysis of resilience in stroke from 2000 to 2024 using CiteSpace and VOSviewer.
    Yaoyao Li, Kim Lam Soh, XiuJuan Jing, Lili Wei, Ruthpackiavathy Rajen Durai, Kim Geok Soh.
       Objective: This study aims to conduct a bibliometric analysis of research literature on psychological resilience among stroke survivors published from 2000 to 2024, utilizing VOSviewer and CiteSpace.
    Methods: The literature data was sourced from the Web of Science Core Collection database (WoSCC). A total of 424 relevant articles, published between January 1, 2000, and April 30, 2024, were included. To analyze the literature, the software tools CiteSpace and VOSviewer were employed, examining perspectives such as authorship, country of origin, institutions, journals, references, and keywords.
    Results: Since 2015, the annual publication output has steadily increased, reaching a peak in 2022 (65 articles). The United States is the most prolific contributor, with Harvard University being the leading institution in this field. Zhang W and Vranceanu A have emerged as the authors with the highest productivity, each boasting five published articles. "Stroke" is the most co-cited journal (204 times) with a high impact factor (IF 2022, 8.4). The most frequently occurring keywords are "stroke," "resilience," "depression," "health," and "quality of life." Emerging trends include research on post-stroke cognitive impairment, meta-analyses, population differences, guideline development, and symptom management.
    Conclusion: This bibliometric study indicates the increased scholarly interest in investigating psychological resilience among persons who have survived a stroke over the last 24 years. The United States and China have emerged as the leading contributors to this study area, with international collaboration on the rise. To enhance this subject, subsequent studies should target refining theoretical frameworks, enhancing assessment instruments, establishing evidence-based guidelines, and developing tailored therapies that increase psychological resilience and holistic well-being for stroke survivors.
    Keywords:  CiteSpace; VOSviewer; bibliometric; mental health; resilience; stroke
    DOI:  https://doi.org/10.3389/fpsyg.2025.1452249
  8. Int J Med Sci. 2025 ;22(11): 2700-2720
    A Bibliometric Analysis of Neuroinflammation in Depression from 2004 to 2023: Global Research Hotspots and Prospects.
    Anni Shi, Na Chen, Qin Ma, Yaxuan Wang, Xiaoling Liu, Jun Lu, Jianyou Guo.
      Background: Neuroinflammation lays a prominent impact in the pathophysiology of depression, and numerous studies have been conducted in recent decades. Bibliometric analysis is of important for understanding the hot spots and research trends in a certain subject field. However, no systematic bibliometric study exists in this field to date. The purpose of the study focused on the trends and hotspots in neuroinflammation of depression and provided future researchers with guidance and sights. Methods: Publications (2004-2023) were obtained from the WoSCC, and analyzed by HistCite, VOSviewer, CiteSpace, and Bibliometrix. The impact of publications was assessed by TGCS. Results: We analyzed 1,496 articles published in 409 journals and authored by 46,533 researchers across 72 countries and regions. The most prolific countries were China, the USA, and Brazil, and the most cited countries were the USA, followed with China and the UK, while the most prolific and cited institution was University Toronto (records=34, TGCS=2,137). Brain Behavior and Immunity is the leading journal that regularly published research in this field (records=93, TGCS=6,247). NLRP3 inflammasome, microglia, TNF-α, and brain-derived neurotrophic factor (BDNF) were the basis of neuroinflammation in depression. C-reactive protein, an important marker of inflammation, has been discussed for the longest time in this disease. In recent five years, two most frontier potential areas in studying depression were gut microbiota dysbiosis and BDNF. Conclusions: There remains a strong research basis for neuroinflammation in depression from this bibliometric analysis. Microglial activation, gut microbiota, cytokine signaling, and oxidative stress were research hotspots in recent years. In the future, chronic stress, hippocampal structure, and gut microbiota will continue to be studied in the field of neuroinflammation in depression. This study may benefit scientists in identifying potential directions for future study and providing clinicians with new ideas for treatment.
    Keywords:  bibliometric analysis; depression; neuroinflammation; research trends; visualization analysis
    DOI:  https://doi.org/10.7150/ijms.100888
  9. J Robot Surg. 2025 Jun 16. 19(1): 297
    Laparoscopic surgical robotics (1999-2023): a bibliometric exploration of technological evolution and research frontiers.
    Peng Cao, Guohui Wang, Hao Ling, Yijia Zeng, Bo Yi, Shaihong Zhu.
      Advancements in robotic-assisted laparoscopic surgery have significantly propelled research development. This study employs bibliometric and visualization techniques to examine the current landscape and emerging trends in this field. Utilizing the Web of Science Core Collection, this study extracted publications on robotic-assisted laparoscopic surgery up to 2023 and conducted bibliometric analysis with systematically integrated data visualization tools and analytical algorithms. Analysis of 8375 scholarly works (6838 articles; 1537 reviews) demonstrates a notable surge in academic productivity and citation impact over the 24-year observation period, particularly accelerating after 2019. Yonsei University ranked first in institutional contributions, while the United States retained its dominance in publication output. Surgical Endoscopy topped the publication volume, whereas European Urology excelled in H-index and Impact Factor rankings. Prominent researchers include Kaouk JH and Menon M, the latter of whom attained the highest average citation count. Frequent keywords such as "robotic surgery" and "laparoscopic surgery" indicate the primary focus areas within the field. Robotic-assisted laparoscopic surgery shows great potential, particularly for abdominal tumor procedures. Future research should emphasize global collaboration, improve research quality, and address geographic disparities to unlock new frontiers in precision surgery and enhance patient outcomes globally.
    Keywords:  Bibliometric; Robotic-assisted surgery; Visual analysis
    DOI:  https://doi.org/10.1007/s11701-025-02475-2
  10. Brain Behav. 2025 Jun;15(6): e70610
    Making Sense of Proprioception by Bibliometric Research.
    Kevser Sevik Kacmaz.
       BACKGROUND: Proprioception is one of the most significant factors in balance, stability, fine movements, coordination, and injury prevention. Proprioception research helps clarify how the nervous system integrates sensory inputs to plan and execute movements. Bibliometric analyses offer a systematic and comprehensive understanding of a field's structure, evolution, trends, research clusters, and gaps, laying a scientific foundation for future research. This study employs bibliometric analysis to provide a panoramic view of proprioception research and to identify its thematic structure, evolution, production, and impact.
    METHODS: A total of 4506 original studies from 1979 to 2024 were extracted from the WoS. Using the Bibliometrix application in RStudio, a bibliometric analysis examined scientific performance, production, citation impact, research trends, developments, and the conceptual framework related to proprioception research. The Biblioshiny application performed the scientific mapping.
    RESULTS: Proprioception research has increased linearly. The most influential article was Sensorimotor System Measurement Techniques, published in the Journal of Athletic Training, with 455 citations. Uwe Proske was the most influential author, with an h-index of 20 in proprioception. The literature utilized 6797 keywords. Of these, 29% was proprioception, 4% joint position sense, and 4% rehabilitation. Keyword trends showed a shift toward rehabilitation and neurophysiology, with terms such as "rehabilitation," "balance," and "stroke" becoming more prevalent. However, an emerging interest in psychophysics, which investigates the interaction between proprioception and sensory perception, is also evident. This theme offers significant opportunities for future research. The USA leads in productivity, contributing 57.70% of the total publications, followed by Canada with 19.32%, and the UK with 18.28%.
    CONCLUSIONS: The results indicate a significant upward trend in research output, highlighting the increasing importance of proprioception in clinical and research settings. The findings emphasize several gaps in current proprioception research, including the need for greater interdisciplinary collaboration, particularly with neuroprosthetics and AI-driven proprioceptive modeling. Furthermore, geographical diversity in research, particularly from underrepresented regions, is critical for comprehensively understanding proprioception across diverse populations. This study provides actionable information for researchers, clinicians, and policymakers. It urges future investigations to address these gaps and explore innovative approaches to enhance proprioception-based therapies and technologies.
    Keywords:  bibliometric; proprioception; rehabilitation; scientific mapping; scientometric
    DOI:  https://doi.org/10.1002/brb3.70610
  11. Medicine (Baltimore). 2025 Jun 13. 104(24): e42898
    Global insights and knowledge mapping of immunity and inflammation in acute pancreatitis: A bibliometric and visual analysis.
    Ming Feng, Siyu Xu.
       BACKGROUND: Despite extensive evidence implicating inflammation in the development and progression of acute pancreatitis, a comprehensive bibliometric analysis focused on this field remains scarce. We aimed to unravel the current research status and identify future directions in the study of inflammation and immunity in acute pancreatitis through a bibliometric analysis.
    METHODS: Relevant literature was retrieved from the Science Citation Index Expanded Database of the Web of Science Core Collection. Data on countries, institutions, authors, journals, documents, references and keywords were analyzed using CiteSpace, VOSviewer, and the R package "Bibliometrix."
    RESULTS: A total of 889 documents, including 845 articles and 44 reviews, published between 1979 and 2024 by 4814 authors from 948 institutions across 50 countries, were included. China (n = 397), Shanghai Jiao Tong University (n = 45), Henrik Thorlacius (n = 15) and Pancreas (n = 58) were the most prolific country, institution, author and academic journal, respectively. The top 10 most highly cited documents focused on intercellular adhesion molecule 1, neutrophils, inflammasome, and the association between early systemic inflammatory response or inflammatory mediator levels and patient outcomes. Keyword analysis indicated that "cytokine," "systemic inflammatory response syndrome," "apoptosis" were most frequent, while emerging keywords included neutrophil extracellular traps, exosome, pyroptosis, macrophage polarization, and NLRP3 inflammasome.
    CONCLUSIONS: This bibliometric analysis suggests that the field of inflammation and immunity in acute pancreatitis is expanding rapidly, encompassing effector cells, mediators, signaling pathways, cell death mechanism, and corresponding clinical outcomes. Future directions may prioritize the pathological, diagnostic and/or therapeutic role of exosomes and pyroptosis to facilitate patient management.
    Keywords:  acute pancreatitis; bibliometric; immunity; inflammation
    DOI:  https://doi.org/10.1097/MD.0000000000042898
  12. Medicine (Baltimore). 2025 Jun 13. 104(24): e42853
    A bibliometric analysis of wearable device research in sleep science: Trends and hotspots.
    Xin Lin, Guoqing Zhang, Shihua Cao, Shengli Wang, Fei Wang, Ming Xu.
       OBJECTIVE: This study aims to examine academic discourse on wearable devices for sleep, evaluating the domain's current landscape and identifying key research foci.
    METHODS: The articles and reviews regarding wearable devices for sleep were culled from the Web of Science Core Collection, spanning the years 2004 to 2025. CiteSpace software was employed to visualize the knowledge map, including publication trends, country, author, journal, and keyword.
    RESULTS: According to the search strategy, a total of 1572 published articles and reviews were retrieved. The number of publications and citations showed an increasing trend over the past 2 decades. Sensors was the most productive journal, while sleep was the most cited. The United States was the most productive country, followed by China and England. The University of California System was leading research hubs in this field. Hannah Scott published the most papers, and Massimiliano de Zambotti was the most frequently co-cited author. The review published by Massimiliano de Zambotti and Shahab Haghayegh in 2019 was the most influential publication. The most frequently occurring keywords in the field of wearable devices for sleep were "physical activity," "sleep," "wearable devices," "heart rate variability," "validation," "actigraphy," "machine learning," "health," "wearable device," "wearable sensors," "validity," and "polysomnography." The keyword "validity" had the highest burst rate, while "dynamics," "atrial fibrillation," "human activity recognition," "major depressive disorder," and "light" emerged as new research hotspots in recent years.
    CONCLUSIONS: This study provides a comprehensive overview of the current state of wearable device research in sleep science. By identifying key trends, influential researchers, and emerging research areas, this study offers valuable insights for future research and development in this field.
    Keywords:  CtieSpace; bibliometric analysis; sleep; wearable devices; wearable sleep technology
    DOI:  https://doi.org/10.1097/MD.0000000000042853
  13. Front Microbiol. 2025 ;16 1598173
    Decoding the gut-sleep Nexus: a bibliometric mapping of gut microbiota and sleep disorders.
    Dingwen Xu, Zihua Lu, Qin Li, Yuchen Cheng, Zhe Yang.
       Background: An increasing number of studies have focused on the interaction between gut microbiota and sleep disorders. However, there is currently no bibliometric analysis of the literature on gut microbiota and sleep disorders. This study employs bibliometric methods to analyze the current research status and hotspots in the field of gut microbiota and sleep disorders, providing a reference for future research in this area.
    Methods: Articles related to gut microbiota and sleep disorders were retrieved from the WOS core database, covering the period from the database's inception to December 31, 2024. After rigorous screening, VOSviewer and CiteSpace were used to conduct analyses on quantity, collaboration networks, clustering, and citation bursts.
    Results: The number of articles on gut microbiota and sleep disorders has increased annually, with a significant surge after 2022. China has the highest number of publications, while the United States has the highest citation count. The institution with the most publications is Shanghai Jiao Tong University, and the institution with the most citations is Deakin University. The top 10 journals by publication volume are all ranked above Q2 in the JCR. The most cited article is "Gut microbiome diversity is associated with sleep physiology in humans" by Smith et al., published in PLOS ONE in 2019. The top 10 most frequent keywords are gut microbiota, sleep, depression, inflammation, chain fatty acids, anxiety, brain, oxidative stress, obesity, and health. The keyword cluster "obstructive sleep apnea" is a focal research direction, while fecal microbiota transplantation is a current research hotspot.
    Conclusion: This study reveals the publication trends, collaboration relationships among countries, regions, and authors, and recent research hotspots in the field of gut microbiota and sleep disorders through bibliometric methods, providing an objective data reference for scientific research in this domain.
    Keywords:  bibliometric analysis; gut microbiota; hotspot; obstructive sleep apnea; sleep disorders
    DOI:  https://doi.org/10.3389/fmicb.2025.1598173
  14. Front Pediatr. 2025 ;13 1558301
    A bibliometric analysis of research trends in mesenchymal stem cell therapy for neonatal bronchopulmonary dysplasia: 2004-2024.
    Lu Bai, Yue Xin.
       Introduction: Bronchopulmonary dysplasia (BPD) is a chronic lung disease predominantly affecting preterm infants, often requiring mechanical ventilation and supplemental oxygen. The pathogenesis of BPD involves a combination of genetic susceptibility and environmental insults, such as oxidative stress and mechanical ventilation. Mesenchymal stem cells (MSCs) have emerged as a promising therapeutic option for BPD due to their immunomodulatory, anti-inflammatory, and regenerative properties. This study aims to perform a bibliometric analysis of the publication landscape surrounding MSC therapy for BPD to identify research trends, collaborative networks, influential research clusters, and emerging research frontiers from 2004 to 2024.
    Methods: A bibliometric analysis was conducted using the Web of Science Core Collection (WoSCC) as the primary database due to its comprehensive citation indexing and standardized metadata. To ensure data integrity, we included publications from January 2004 (when the first relevant MSC studies for BPD began appearing) to November 2024. The search query combined terms related to BPD and MSCs, focusing on English-language articles and reviews. After retrieval, data were cleaned through duplicate removal and relevance verification processes. Quantitative analysis was performed on publication counts, authors, journals, institutions, and countries. Visual analysis tools, VOSviewer ( 1) and CiteSpace ( 2), were employed to map collaboration networks and identify research clusters through co-citation and co-occurrence analyses. Statistical validation of bibliometric distributions was conducted using Bradford's law and Price's law. Citation metrics were normalized by publication year to account for citation accumulation bias.
    Results: A total of 353 publications were analyzed, including 216 articles and 137 reviews, from 555 institutions across 35 countries. Time-series analysis revealed a significant acceleration in publication output after 2015 (p < 0.01), with a compound annual growth rate of 18.2%. The United States was the leading contributor (131 publications, 37.1%), followed by China (72 publications, 20.4%) and Canada (54 publications, 15.3%). Network analysis identified five distinct collaborative clusters, with limited cross-cluster collaboration. Citation analysis, normalized for publication age, revealed that the American Journal of Respiratory and Critical Care Medicine had the highest field-weighted citation impact (3.8). Keyword co-occurrence analysis demonstrated a significant shift from whole-cell therapies to extracellular vesicle research after 2018, with "microvesicles" and "exosomes" emerging as high-intensity burst terms (burst strength >5.0). The co-citation analysis identified three primary research clusters: stem cell therapy mechanisms (42.3% of citations), respiratory physiology and pathology (38.1%), and clinical neonatology (19.6%).
    Conclusion: This bibliometric analysis maps the evolving landscape of MSC therapy research for BPD over the past two decades, revealing distinct research clusters with limited cross-disciplinary integration. Our findings demonstrate a clear shift from whole-cell MSC investigations toward MSC-derived exosomes as a cell-free therapeutic approach, particularly since 2018. Despite the growing body of preclinical evidence, visualization of publication patterns reveals significant gaps between laboratory findings and clinical applications, with only 8.2% of publications reporting clinical outcomes. The analysis further highlights geographical imbalances in research contributions and collaborative networks, suggesting opportunities for broader international engagement. These findings provide a foundation for directing future research efforts toward addressing knowledge gaps, particularly in understanding precise mechanisms of action and establishing standardized clinical protocols.
    Keywords:  bibliometric analysis; bronchopulmonary dysplasia; citation analysis; international collaboration; mesenchymal stem cells; research trends
    DOI:  https://doi.org/10.3389/fped.2025.1558301
  15. J Perianesth Nurs. 2025 Jun 17. pii: S1089-9472(25)00017-6. [Epub ahead of print]
    Mapping the Nursing Literature on Postoperative Pain: A Bibliometric Analysis.
    Havvane Kulaksızoğlu, Seçil Taylan, Fatma Eti Aslan.
       PURPOSE: To evaluate nursing research related to postoperative pain through bibliometric analysis and to provide a structured macroscopic overview of the characteristics and development of this research.
    DESIGN: A bibliometric analysis.
    METHODS: The Web of Science database was selected for the bibliometric analysis study, with data included up to August 30, 2024. The analysis was performed using the "biblioshiny" application available in the Bibliometrics R package.
    FINDINGS: A total of 3,410 nursing articles on postoperative pain were published in 976 sources from 1975 to 2024. The journals with the highest number of publications were Pain Management Nursing, Journal of Perianesthesia Nursing, and Journal of Clinical Nursing. According to Bradford's law-based analyses, there are 26 journals in the first zone, 168 journals in the second zone, and 782 journals in the third zone. Wang J, Kehlet J, and He HK were the most prolific authors. The study found that the distribution of authors did not follow Lotka's law. Developed countries were the most prolific in nursing publications on postoperative pain, and these countries had the highest number of collaborative publications. Keywords focused on "management," "surgery," "nursing," and "pain," with "management," "surgery," and "postoperative pain" being the most concentrated themes in the thematic map. Gaps in the literature included "education," "women," "mortality," "programme," and "rehabilitation," while key themes requiring further development were identified as "pain," "analgesia," "anaesthesia," "quality of life," "risk factors," and "risk."
    CONCLUSIONS: This bibliometric study provides a comprehensive and integrative review of the global literature on postoperative pain in nursing.
    Keywords:  bibliometric analysis; nursing; postoperative pain
    DOI:  https://doi.org/10.1016/j.jopan.2025.01.017
  16. J Emerg Med. 2025 May 22. pii: S0736-4679(25)00186-6. [Epub ahead of print]
    Bibliometric Analysis of 25 Years of Emergency Medicine Research in Latin America.
    Augusto Maldonado, Martín Coral, Gabriela Hernández.
       BACKGROUND: The global landscape of Emergency Medicine (EM) research has been extensively studied through bibliometric analyses, revealing patterns in productivity, impact, and collaboration. However, these analyses consistently highlight a significant disparity in scientific output, particularly in Latin America.
    OBJECTIVE: This study aims to analyze the scientific production and trends in EM research in the last 25 years in Latin America, identify the main thematic trends, and discuss opportunities for improvement in carrying out high-level scientific research that could benefit the region's healthcare.
    METHODS: We performed a bibliometric analysis of the Latin American EM scientific output from 2000 until 2024 in Scopus, Clarivate Analytics' Web of Science Core Collection, and Clarivate Analytics' Web of Science SciELO Citation Index. The analysis was made using Bibliometrix and Biblioshiny packages in R-Studio.
    RESULTS: We identified 8499 articles written by 45,583 authors, with 8.52% international collaborations with an average annual increase in publication rate of 12.5%. The most productive countries were Brazil, Colombia, and México. The main outlets for publications were local journals not closely related to EM and international journals like the American Journal of EM, among others. The most common topics were emergency services, traumatic brain injury, trauma, and coronavirus disease 2019.
    CONCLUSION: This study identified limited publications by Latin American researchers in EM. However, there is promising space to organize, improve, and create opportunities to publish data to address emergency care in Latin America.
    Keywords:  Bibliometrix; Emergency Medicine; bibliometric analysis; global health; healthcare disparities
    DOI:  https://doi.org/10.1016/j.jemermed.2025.04.035
  17. Front Neurol. 2025 ;16 1623956
    Research progress in intracranial artery dissections over past 25 years: a review and bibliometric analysis.
    Zixuan Zhou, Bingyang Qin, Yang Chen, Ren Li, Biao Yang, Ziao Li, Yongqiang Wu, Xiaogang Wang, Xiaolong Guo, Wenju Zhang, Yuanli Zhao, Geng Guo.
       Background: A bibliometric and visual analysis of articles related to intracranial artery dissection (IAD) was performed to reveal the academic developments in this research field, to better assist researchers in reviewing previous research results, exploring current scientific research hotspots and cutting-edge trends, and obtaining a global perspective on IAD research.
    Methods: Articles on IAD published from January 1, 2000 to March 15, 2025 were searched, screened, and downloaded using the Web of Science Core Collection (WoSCC). All literature included in the study was analyzed using VOSviewer, CiteSpace and Microsoft Excel.
    Results: A total of 1,130 articles were included in the bibliometric analysis from January 2000 to March 2025, with a general upward trend in the number of articles published each year, peaking in 2019 for annual publications. Collaboration network analysis showed that the United States, Japan, and Germany are the more influential countries in the field, with high numbers of published articles, citations, and collaborations with other countries. The journal with the most publications was World Neurosurgery. Lawton MT was the most active author with a cumulative total of 13 articles, while Biller J received the highest number of citations with a cumulative total of 1,033. Keyword analysis of the literature showed that "recanalization "reached the highest intensity of outbreaks, while "thrombectomy "," outcome ", "risk ", and "diagnosis "showed an increase in citations in 2025, indicating that these subjects continue to be of significant interest.
    Conclusion: This study explores the evolving research trends and challenges in the area of IAD, presenting a thorough examination of both its historical and current research contexts. It offers valuable direction for future scholarly pursuits. By engaging in comprehensive research and examining various perspectives within the IAD domain, new insights can be uncovered, ultimately facilitating precise diagnosis and effective treatment of the condition.
    Keywords:  bibliometric analysis; clinical diagnosis and treatments; hotspots; intracranial arterial dissection; pathophysiology
    DOI:  https://doi.org/10.3389/fneur.2025.1623956
  18. Discov Oncol. 2025 Jun 19. 16(1): 1154
    Visualization of research trend of neoadjuvant chemotherapy for breast cancer treatment: a bibliometric analysis.
    Tian Tian, Chao Li, Chao Hu, Xiandong Liu, Pingming Gong, Ming Li, Nan Jiang.
       PURPOSE: Neoadjuvant chemotherapy (NAC) is a cornerstone in the treatment of breast cancer, aimed at shrinking tumors preoperatively and improving surgical outcomes. Although the literature volume has shown an annual growth trend, no comprehensive bibliometric and clinical analysis covering multiple databases in this field is available. The study aims to identify key contributions to the field and provide insights for future research directions.
    METHODS: The articles were obtained from the Web of Science Core Collection (WoSCC) on breast cancer in the past decades (from 1999 to 2024). VOSviewer 1.6.17, CiteSpace 5.8.R.1 and package "bibliometrix" were used to conduct this bibliometric analysis.
    RESULTS: We included 11,505 articles and the top 100 cited journals from WOSCC for analysis. The USA had the highest number of publications, and most of the top 100 cited articles were from the USA. Sibylle Loibl, Michael Untch, and Von Minckwitz G have made significant contributions through their high research productivity and the publication of high-quality articles; Von M was the most cited author from the top 100 cited journals. Keyword co-occurrence studies suggested that the research hotspots in the field of NAC for breast cancer focus on survival rate, preoperative chemotherapy, and overall treatment strategy. Increased clinical trials and randomized trials on preoperative chemotherapy and the use of positron emission tomography, especially for triple-negative breast cancer (TNBC), have attracted wide attention and research in the academic community over a specific period.
    CONCLUSION: This study presents a bibliometric analysis on NAC for breast cancer, highlighting research trends, influential studies, and collaborative networks. This data analysis highlights key research gaps in NAC for breast cancer, including limited international collaboration, underexplored treatment strategies for aggressive subtypes like TNBC, and the need for more high-quality trials to optimize personalization and response prediction.
    Keywords:  Bibliometric analysis; Breast cancer; Neoadjuvant chemotherapy; Prognosis; Research trends
    DOI:  https://doi.org/10.1007/s12672-025-02950-0
  19. Future Microbiol. 2025 Jun 20. 1-12
    Research trends and hotspots in viral neglected tropical diseases: a bibliometric analysis.
    Yuni Wang, Mengqi Zhang, Mingyu Li, Yajun Lu.
       BACKGROUND: The World Health Organization's "2021-2030 Strategic Plan for Neglected Tropical Diseases (NTDs)" spotlights 21 NTDs, including three viral pathogens: Dengue, Rabies, and Chikungunya. These diseases, prevalent in tropical and subtropical areas, pose a global health threat driven by globalization. Comprehending their research trends and hotspots is vital. Hence, this bibliometric analysis aims to reveal the global research landscape and guide future strategies of viral NTDs.
    METHODS: Data from the Science Citation Index Expanded of the Web of Science Core Collection (WoSCC) was analyzed for the period 2014-2023, focusing on publications related to Dengue, Rabies, and Chikungunya. Bibliometric analysis and visualization were carried out using VOSviewer, Bibliometrix in RStudio, and CiteSpace to generate descriptive statistics and identify latent thematic structures.
    RESULTS: The analysis covered 13,472 publications from 184 countries/regions, involving 12,219 institutions/organizations, published across 1,673 journals by 56,733 researchers. An upward trend in annual publication output was seen from 2014 to 2021, peaking at 1,534 articles in 2021, followed by a significant drop. Bibliometric indicators were used to identify core journals, prolific authors, leading institutions, dominant countries, and emerging research themes.
    CONCLUSION: The study offers valuable insights and practical guidance for researchers in the domain of viral NTDs.
    Keywords:  Neglected tropical diseases (NTDs); bibliometric analysis; chikungunya; dengue; rabies
    DOI:  https://doi.org/10.1080/17460913.2025.2520694
  20. J Epidemiol Glob Health. 2025 Jun 20. 15(1): 87
    Global Research Trends in Pediatric Acute Respiratory Distress Syndrome: A Bibliometric Analysis from 2014 To 2024.
    Keke Chen, Chengjie Chen, Xiang Zheng, Sihu Chen, Guoquan Pan, Yafeng Liang.
       BACKGROUND: To assess an overview of research trends, influential studies, and collaborative networks in pediatric acute respiratory distress syndrome (PARDS), identifying key contributions and insights for future research directions.
    METHODS: Web of Science Core Collection (WoSCC) database was used to conduct the bibliometric analysis. Bibliometric indicators such as publication counts, citation frequencies, authors, countries/regions, institutions and keyword occurrences were analyzed using VOSviewer and CiteSpace and R.
    RESULTS: The analysis included 419 publications from 2014 to 2024, with a total of 88,849 citations. These publications involved 22,141 authors affiliated with various institutions worldwide. the United States leading in research output, contributing 1,124 articles and 24,421 citations. Leading institutions included the University of Pennsylvania, the University of California System, and the Children's Hospital of Philadelphia. The most influential journals were Pediatric Critical Care Medicine and Critical Care Medicine. Yehya N, Thomas NJ, and Khemani RG are the most contributed authors. Keyword co-occurrence analysis revealed five major research clusters: neonatal outcomes, critical care strategies (e.g., mechanical ventilation and extracorporeal membrane oxygenation [ECMO]), inflammation and immune mechanisms, respiratory support interventions, and diagnostic tools like lung ultrasound. Emerging trends focused on inflammation, molecular mechanisms, and diagnostic advancements.
    CONCLUSION: This study presents a bibliometric analysis of PARDS research, highlighting significant trends, influential studies, and collaborative networks. The findings provide valuable insights into the current state of research and future directions for advancements, emphasizing the need for continued investigation to improve clinical outcomes for children with ARDS.
    CLINICAL TRIAL NUMBER: Not applicable.
    Keywords:  ARDS; Bibliometric analysis; Pediatric ARDS; Respiratory failure
    DOI:  https://doi.org/10.1007/s44197-025-00434-6
  21. Front Neurosci. 2025 ;19 1616973
    Electrophysiology in neuropathic pain: a bibliometric analysis and literature review.
    Yidan Cui, Chen Lv, Wenjian Yan, Lidan Zhang, Ning Sun, Xin Zhang, Zhen Zhong.
       Objective: Neuropathic pain (NP), a prevalent chronic condition with increasing global incidence, mainly relies on electrophysiology (EP) to decode its mechanisms. However, existing research lacks systematic integration, failing to track hotspots and frontiers effectively. In this study, we used bibliometric analysis and systematic review to clarify technological breakthrough directions and facilitate the development of electrophysiological phenotype-based precision diagnostics.
    Methods: Literature was retrieved from the Web of Science Core Collection (WoSCC). A total of 2,234 reviews and articles were obtained from 2005 to 2024. Statistics and visualization analysis were performed using Bibliometrix (R), VOSviewer, CiteSpace, and Microsoft Excel 2024.
    Results: Publications and citations in this field are rising. The USA leads in publications (613, 27.44%) and academic impact (H-index = 96). China's academic impact remains behind when compared to other countries. North American and Western European institutions form robust collaboration networks, whereas Asian institutions exhibit weaker regional partnerships. Authors with high production, such as Khanna, Rajesh and Waxman, Stephen G, and highly cited authors such as Woolf, CJ play a key leading role in the development of the field. Journals like Pain and Journal of Neuroscience are the cardinal dissemination mediums. Keyword analysis reveals research hotspot expands from the basic structure of "dorsal root ganglion" and" sensory neuron" to pain-related dynamic changes and disease prevalence characteristics. "Plasticity" and "connectivity" signaled a shift in research toward network mechanisms and precise interventions. "Woolf CJ, 2011" and "Dib-Hajj SD, 2010" have high citation and co-citation frequencies. The emergence of new directions such as "dynamic pain connectome" and "computational modeling research" reflects the trend of multidisciplinary integration.
    Conclusion: For the first time, we have constructed a complete lineage from basic research to clinical translation in this field, confirming the key role of EP technology in analyzing the mechanism of nociceptive sensitization, neuroplasticity, and neural network connectivity reconfiguration, which provides a basis for developing precise diagnostic and therapeutic solutions based on electrophysiological phenotypes. Future research should focus on technology standardization, cross-institutional data sharing, clinical translation, and connectomics-oriented individualized analgesic strategies to promote NP diagnosis and treatment toward precision, dynamics, and systematization.
    Keywords:  CiteSpace; VOSviewer; bibliometrics; electrophysiology; neuropathic pain
    DOI:  https://doi.org/10.3389/fnins.2025.1616973
  22. J Thorac Dis. 2025 May 30. 17(5): 3106-3117
    Tracheostomy in COVID-19 critically ill patients: a bibliometric and visual analysis.
    Raffaele Merola, Stefania Troise, Antonio Romano, Maria Vargas.
       Background: Coronavirus disease 2019 (COVID-19)-induced acute respiratory failure often necessitates prolonged intubation and invasive mechanical ventilation, with tracheostomy frequently performed in critically ill patients requiring extended mechanical ventilation. Bibliometrics, employing statistical methods to scrutinize research papers on specific topics mathematically, has not yet been applied to analyze publications concerning tracheostomy in COVID-19 critically ill patients. This study employs bibliometric techniques to scrutinize publications addressing this topic.
    Methods: The global literature on tracheostomy in COVID-19 from 2020 to 2023 was surveyed using the Scopus database. VOSviewer facilitated the bibliometric analysis of these articles.
    Results: The Scopus database yielded 1,268 records on tracheostomy in COVID-19 critically ill patients. Following independent screening by two reviewers, 359 papers were ultimately selected. Michael J. Brenner and Luis Angel emerged as the most prolific and cited authors, respectively. Numerous organizations contributed to related publications, with the Global Tracheostomy Collaborative leading in activity. The Amandela ENT Head and Neck Centre of Singapore and the National University Hospital of Singapore were the most cited organizations. Publications on tracheostomy in COVID-19 originated from 77 countries; the USA was the most active and cited. A total of 135 journals published the related papers, with the European Archives of Oto-Rhino-Laryngology having the most publications and citations. Co-citation analysis identified JAMA as the most cited source and Brenner MJ as the most cited author among 6,726 cited authors.
    Conclusions: This bibliometric analysis provides a comprehensive perspective on the existing literature regarding tracheostomy in COVID-19.
    Keywords:  Bibliometric analysis; coronavirus disease 2019 (COVID-19); intensive care unit (ICU); severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); tracheostomy
    DOI:  https://doi.org/10.21037/jtd-2024-1949
  23. Int J Ophthalmol. 2025 ;18(6): 1131-1145
    Mapping key trends, relationships, and molecular pathways for neuroprotection in glaucoma: a bibliometric approach.
    Puneet Agarwal, Renu Agarwal, Igor Iezhitsa.
      Glaucoma, a degenerative optic neuropathy, causes retinal ganglion cell (RGC) apoptosis and irreversible vision loss. Current therapies often fail to stop disease progression despite lowering intraocular pressure, the main risk factor. Thus, neuroprotective strategies have gained interest. We performed a bibliometric analysis to determine global publishing trends and relationships among prolific authors, publications, institutions, funding agencies, and journals. We also analyzed author keywords to identify research hotspots in glaucoma neuroprotection. Further, based on keyword analysis, we reviewed most recent literature to understand mechanistic pathways underlying glaucoma-related pathophysiological responses leading to RGC loss. Bibliographic data were sourced from Scopus. Basic bibliographic features were characterized using Scopus's functions. VOSviewer was used for mapping and visualizing bibliometric networks. The analysis included trends in publications since 2000, the most prolific countries, institutions, authors, and the strength of their linkages. A significant increase in publication output over the past two decades was noted. The United States leads in funding support, research output, and citation links, followed by China and the UK. Among the top 10 most cited authors, three are from Japanese institutions. Keyword analysis shows a focus on molecular targets related to ischemia, excitotoxicity, inflammation, and oxidative stress, with fewer emerging drug candidates and limited clinical trials. Based on the most recent literature, emerging molecular targets underlying these key pathophysiological mechanisms are summarized. In conclusion, while pathophysiology and molecular mechanisms are the current focus, there is not much progress in developing new drug candidates and conducting clinical trials.
    Keywords:  bibliometric analysis; glaucoma; molecular pathways; molecular targets; neuroprotection; publishing trends
    DOI:  https://doi.org/10.18240/ijo.2025.06.21
  24. Front Oncol. 2025 ;15 1588598
    Current status, hotspots and frontiers of ion channel-related research in glioblastoma: a bibliometric analysis from 2005 to 2024.
    Zefeng He, Jing Liu, Qianxu Jin, Shangkun Ren, Liang Liu, Yingzi Liu.
      Glioma is the most common primary tumor of the central nervous system, with glioblastoma being its predominant pathological type. In recent years, research has demonstrated that ion channels are intricately linked with numerous biological processes in tumor cells, including apoptosis and migration, among others. This study employs bibliometric analysis to systematically examine and synthesize the knowledge structure and research focal points in the field of glioblastoma ion channels. Publications related to ion channels in glioblastoma, published between January 1, 2005 and December 31, 2024, were retrieved from the Web of Science Core Collection (WoSCC). The dataset comprises 764 articles and 234 reviews. Utilize VOSviewer, CiteSpace, Bibliometrix, and Excel to conduct an in-depth analysis and visualization of scholarly contributions based on country, institution, journal, and author. Additionally, examine highly cited publications, references, and keywords. From 2005 to 2024, the number of publications in this field has shown a consistent annual increase. The University of Alabama and Cancer are among the leading institutions and journals. Sontheimer Harald, from the United States, is the most prolific author in this field. The analysis of highly cited publications and co-cited references indicates that the research background and foundation focus on elucidating the mechanisms by which ion channels influence the onset and progression of glioblastoma. Keyword analysis indicated that "tumor microenvironment" (burst strength: 4. 67), "Ca2+ activated K+ channel" (burst strength: 3. 98), and "chloride channels" (burst strength: 3. 59) have been the keywords exhibiting the highest burst intensity over the past two decades. The keywords that have emerged with higher frequency in the past five years include "tumor microenvironment" (burst strength: 4. 67), "receptor" (burst strength: 3. 11), and "channels" (burst strength: 3. 11). Research on ion channels in glioblastoma has emerged as a prominent and rapidly evolving field of interest. Previous studies have primarily focused on the examination of specific ion channels and their functionalities. However, recent keyword analysis highlights the necessity to explore the interaction between ion channels and the tumor microenvironment. Meanwhile by integrating single-cell spatial transcriptomics and nanoparticle technologies, we can significantly enhance the efficacy of ion channel-targeting therapies.
    Keywords:  apoptosis; bibliometric analysis; glioblastoma; ion channel; nanoparticle; single-cell spatial transcriptomics; tumor microenvironment
    DOI:  https://doi.org/10.3389/fonc.2025.1588598
  25. Front Oncol. 2025 ;15 1515476
    Emerging trends of the tumor microenvironment in peritoneal malignancies (2010-2024): a visualization analysis.
    Hua Duan, Mengqi Cheng, Qianhui Sun, Cihui Chen.
       Background: Peritoneal malignancies (PM) represent a group of highly heterogeneous tumors associated with poor prognosis and limited effective treatment options. Recent studies have demonstrated significant progress in understanding the tumor microenvironment (TME) of PM. However, no bibliometric analysis focusing on PM and TME has been conducted. This study aims to provide a comprehensive assessment of the current research landscape and to identify key areas of interest and emerging trends in this field from a bibliometric perspective.
    Methods: Publications related to the TME in PM from 2010 to 2024 were retrieved from the Web of Science Core Collection database. Microsoft Excel, VOSviewer, CiteSpace, and R package "bibliometrix" were used to perform the visualization analysis.
    Results: A total of 862 papers from 56 countries were included. Both annual publication counts and citations have increased steadily over time. The United States of America (USA) contributed the highest number of publications and demonstrated the greatest impact, followed by China and Japan. The University of Texas MD Anderson Cancer Center, Sichuan University and Fudan University were identified as the leading research institutions. Four of the top five most prolific authors are from Japan, including Kajiyama Hiroaki, Yashiro Masakazu, Fushida Sachio and Kinoshita Jun. Cancers published the largest number of articles, with 56 publications, while Cancer research was the most frequently co-cited journal. Reference and keyword burst detection revealed that research hotspots include cytoreductive surgery, hyperthermic intraperitoneal chemotherapy, immunotherapy, tumor-associated macrophages, cancer-associated fibroblast and endothelial growth factor.
    Conclusions: This study summarizes recent research frontiers and hotspots regarding the TME in PM and provided valuable references for future investigations. Immunotherapy targeting the TME is likely to become a major research direction.
    Keywords:  cancer-associated fibroblast; cytoreductive surgery; hyperthermic intraperitoneal chemotherapy; immunotherapy; peritoneal malignancies; tumor microenvironment; tumor-associated macrophages; visualization analysis
    DOI:  https://doi.org/10.3389/fonc.2025.1515476
  26. Curr Protein Pept Sci. 2025 Jun 13.
    Global Trends in Hepatocellular Carcinoma and TGF-β Research: A Bibliometric and Visualization Analysis from 2000 to 2024.
    Liu-Lin Yang, Xing Chen, Kai-Ting Huang, Ji-Long Wang.
       BACKGROUND: Transforming growth factor-beta (TGF-β) plays a pivotal role in advanced hepatocellular carcinoma (HCC) by modulating immune responses, inflammatory processes, and epithelial-mesenchymal transition (EMT) in hepatocytes. It has emerged as a key therapeutic target for HCC.
    OBJECTIVE: This study employs bibliometric analysis to examine literature published between 2000 and 2024, aiming to explore the critical roles of TGF-β in HCC and provide a theoretical foundation for future research.
    METHODS: This study utilized the Web of Science Core Collection (WoSCC) database to analyze publications from January 1, 2000, to October 16, 2024. Visualization tools such as CiteSpace, VOSviewer, and SCImago Graphica were utilized to assess publication trends, countries, institutions, journals, authors, keywords, and references, identifying hotspots, trends, and the evolution of TGF-β research in the context of HCC.
    RESULTS: The analysis encompassed 3,026 publications originating from 79 different countries. China was identified as the leading country in publication volume, with Fudan University being the most prolific institution. The journal Hepatology stood out as the leading publication in terms of both the volume of articles and citation influence. Keyword analysis revealed that recent research (2020-2024) has focused on metabolic regulation, the tumor immune microenvironment, and targeted therapies related to the TGF-β signaling pathway in HCC.
    CONCLUSION: This study highlights the publication landscape, research trends, and hotspots of TGF- β-related HCC research from 2000 to 2024, providing valuable insights and a theoretical basis for future studies in this critical field.
    Keywords:  Hepatocellular Carcinoma; TGF-β; bibliometrics; hotspots.; visualization
    DOI:  https://doi.org/10.2174/0113892037378714250529063227
  27. Ann Plast Surg. 2025 May 28.
    Understanding Research Trends in Facial Synkinesis: A Bibliometric Analysis of the 100 Most Impactful Studies.
    Elena Millesi, Leo F Nonnenbroich, Julian S Rechberger, Carrie E Robertson, Waleed Gibreel, Samir Mardini.
       BACKGROUND: Facial synkinesis is characterized by involuntary co-contraction of facial muscles during voluntary movements, impairing both function and aesthetics following facial paralysis. It affects approximately 21% of individuals following Bell's palsy, with symptoms such as involuntary eye closure when smiling. While the pathophysiology remains unclear, therapeutic options range from conservative approaches like botulinum toxin to surgical interventions. A bibliometric analysis offers insights into research trends, key contributors, and knowledge gaps in this field.
    MATERIALS METHODS: A systematic search was conducted in the Scopus database up to July 2024, identifying 100 most-cited articles on facial synkinesis. Articles were categorized as basic science (BSc), clinical (CL), or review articles, with additional data extracted on study focus, journal type, citation metrics, and authorship. Statistical analyses included Pearson's χ2 and Wilcoxon rank sum tests.
    RESULTS: The articles spanned 1952-2020, with the highest publication frequency in 2017. Clinical studies constituted 76%, focusing on conservative treatments (35%), diagnostics (28%), and surgical interventions (19%). Plastic surgery and ENT journals accounted for 76% of publications. The most-cited article, published in neurology (1975), investigated electrophysiologic diagnostics. Citation metrics revealed a mean citation count of 38.3 and a median publication year of 2010. The 50 newer articles demonstrated a trend toward surgical management of synkinesis.
    CONCLUSIONS: This bibliometric analysis highlights the evolution of research on facial synkinesis, emphasizing the predominance of clinical studies, focus on conservative treatments and gaps in basic science research. Further research is needed to fill knowledge gaps to improve outcomes for affected patients.
    Keywords:  basic science; clinical; facial nerve injury; facial palsy; facial reanimation; most-cited; nonflaccid facial paralysis; postfacial paralysis synkinesis
    DOI:  https://doi.org/10.1097/SAP.0000000000004410
  28. Front Psychiatry. 2025 ;16 1526225
    Global trends and research hotspots in the treatment of mental disorders with transcranial magnetic stimulation: a bibliometric analysis.
    Zong-Ke Ma, Yi-Xin Wei, Ling Rao, Bao-Jin Li, Qiang Gao.
       Background: Transcranial Magnetic Stimulation (TMS) is increasingly utilized in the treatment of mental disorders (MD). The exploration and expanding application of various new TMS mode have significantly propelled the advancement of related clinical research.
    Methods: We reviewed research published in the Science Citation Index Expanded of Web of Science Core Collection database. Using Citespace 6.1, Vosviewer 1.6.20, and Scimago Graphica 1.0.38 software, we conducted a comprehensive visual analysis of TMS on MD from multiple dimensions, including influential countries/regions, institutions, authors, and high-frequency keywords and burst keywords.
    Results: A total of 611 papers between 1996 and 2023 were identified. Recently, the application of TMS on MD have gained increasing recognition. The USA leads in research publications in this field, followed by Germany and China. Institutionally, the University of Toronto in Canada ranks first (n=48); Professor Zafiris J. Daskalakis from the University of California tops among individual researchers (n=24). Cluster analysis of keywords reveal four representative clusters, demonstrating shifts in research focus and direction over time. Current hotspots focus on exploring the effectiveness of different TMS modes and stimulation targets in treating severe depression, obsessive-compulsive disorder, and schizophrenia. Analysis of burst keywords indicated that the latest research are the feasibility and safety of various emerging TMS stimulation mode for treating refractory depression, obsessive-compulsive disorder, negative symptoms of schizophrenia.
    Conclusions: Our study provides valuable insights into the current hotspots and emerging trends of TMS in the treatment of MD, providing a direction for future research to consider.
    Keywords:  bibliometric analysis; depression, obsessive-compulsive disorder; mental disorders; safety; transcranial Magnetic Stimulation; trends and hotspots
    DOI:  https://doi.org/10.3389/fpsyt.2025.1526225
  29. Front Immunol. 2025 ;16 1586120
    Bibliometric and visualized analysis of global distribution and research frontiers in tumor immune escape.
    Chaihong Zhang, Lihong Chen.
       Background: Tumor cells employ various mechanisms to evade detection and attack by the immune system, a phenomenon known as tumor immune escape, which represents a significant target for immunotherapy. Both primary and secondary immune escape mechanisms pose substantial challenges that hinder the efficacy of immunotherapy. This study aims to systematically examine the knowledge structure, hotspot frontiers, emerging trends, and future directions in the field of tumor immune escape through the application of bibliometric methods and knowledge mapping analysis.
    Methods: A comprehensive search of the Web of Science Core Collection (WoSCC) was conducted for publications pertaining to tumor immune escape from January 1, 2015, to November 30, 2024. The annual publication data retrieved from the WoSCC were analyzed utilizing Microsoft Office Excel 2019. Furthermore, bibliometric analysis and visualization were executed using VOSviewer, Biblioshiny, and CiteSpace.
    Results: This study encompassed a total of 11,128 articles published across 1,612 journals, authored by 71,684 individuals affiliated with 9,254 institutions in 121 countries. The United States, China, and Germany emerged as the leading contributors to this field, collectively accounting for 79.99% of all publications. Notable international collaboration was observed between the United States and China. Frontiers in Immunology, Nature Communications, the Journal for ImmunoTherapy of Cancer, and Nature were identified as the four most influential journals in tumor immune escape research. Zhang Wei was noted for the highest publication output, while Freeman Gordon J achieved the highest citation rate. Fudan University was recognized as the most productive institution, whereas Harvard Medical School was acknowledged as the most cited institution. Current hotspot frontiers in tumor immune escape research include immunotherapy, the tumor microenvironment, PD-L1, and PD-1. Additionally, emerging frontiers in recent years encompass immune checkpoint inhibitors, immune infiltration, natural killer cells, extracellular vesicles, immunogenic cell death, metabolism, ferroptosis, melanoma, lung adenocarcinoma, and prognosis.
    Conclusion: A comprehensive investigation into the mechanisms of tumor immune escape is essential for overcoming the existing challenges in immunotherapy. This study systematically analyzes the current state, research frontiers, and future directions, identifying the most prolific and highly cited documents, journals, authors, institutions, and countries in the field of tumor immune escape.
    Keywords:  CiteSpace; VOSviewer; biblioshiny; immune escape; immunotherapy; tumor
    DOI:  https://doi.org/10.3389/fimmu.2025.1586120
  30. J Perianesth Nurs. 2025 Jun 19. pii: S1089-9472(25)00040-1. [Epub ahead of print]
    Research Trends and Hotspots in Postoperative Pain and Nursing: A Bibliometric Analysis.
    Gamze Bozkul, Gülay Altun Uğraş.
       PURPOSE: The present study employs bibliometric analysis to examine the research trends and hotspots pertaining to postoperative pain and nursing.
    DESIGN: Bibliometric analysis.
    METHODS: We performed the search procedure through the "advanced search" function of the Web of Science using the terms "postoperative pain* and nurs*" with no limitation regarding publication year. In the database, we only sought original articles and early access research published in the English language. The data were analyzed using the Bibliometrix package of the R software (R Development Core Team).
    FINDINGS: Our quantitative analysis of the academic literature on nursing and postoperative pain reveals a steady rise in the number of studies published annually over the past decades, with a notable peak in 2022. The journal hosting the highest number of articles on the subject is Pain Management Nursing and Journal of Perianesthesia Nursing. Besides, the United States is at the vanguard of global collaborations and publication production on the subject. Pharmacological treatments for pain management following surgery used to be a prominent aspect, whereas the focus is on nursing care in the present day.
    CONCLUSIONS: To conclude, this study provides valuable insights into the current status of nursing and postoperative pain management. It also presents a comprehensive overview of the subject, highlighting key areas for further research and development. Global research collaborations to facilitate the advancement of evidence-based nursing care in postoperative pain management would continue nurturing the relevant literature.
    Keywords:  bibliometric analysis; nursing; postoperative pain
    DOI:  https://doi.org/10.1016/j.jopan.2025.02.002
  31. Front Aging Neurosci. 2025 ;17 1570428
    Bibliometric analysis of global research on PD-L1/PD-1 pathway and neurodegenerative diseases over the last two decades (2004-2023).
    Jialin Wu, Chaojin Zhang, Qiang Cao, Wei Xuan, Xiaorong Huai, Jie Zhou, Jie Tian.
       Background: Programmed death receptor 1 (PD-1), encoded by the PDCD1 gene, functions as a pivotal immunosuppressive molecule. Neurodegenerative diseases (NDDs) encompass a diverse array of neurological disorders that adversely impact the lives of millions of individuals globally. The current study discusses the impacts of PD-L1/PD-1 signaling on NDDs.
    Methods: A comprehensive online search was conducted using the Web of Science Core Collection database (WOSCC), with a limited time frame set from 2004 to 2023. Data were analyzed with CiteSpace, VOSviewer, and bibliometric package to explore trends in research output, key authors, institutions, journals, and thematic developments.
    Results: This study analyzed 366 publications within the field of PD-L1/PD-1 and NDDs. During 2004-2023, there's an overall upward trajectory in the number of publications as the years progressed. The United States has a significant influence in this field, accounting for the highest number of publications. It also boasts the top two authors, six of the top 10 journals, and four of the top five institutions in terms of article count. Keyword burst analysis identified EAE, Parkinson's disease, adaptive immunity, immune checkpoint blockade, and cerebrospinal fluid are research hotspots in recent years.
    Conclusion: This field has garnered increasing research attention, with the United States being the primary contributor. Recent studies have concentrated on the mechanisms through which PD-L1/PD-1 influences NDDs, and research into cerebrospinal fluid may persist as a focal point in the years to come. While the neuroprotective vs. neurodegenerative effects of PD-L1/PD-1 signaling remain controversial, this pathway represents a promising diagnostic and therapeutic target for NDDs.
    Keywords:  CiteSpace; PD-1; PD-L1; VOSviewer; bibliometric analysis; neurodegenerative diseases
    DOI:  https://doi.org/10.3389/fnagi.2025.1570428
  32. Front Med (Lausanne). 2025 ;12 1532640
    Artificial intelligence in endoscopy and colonoscopy: a comprehensive bibliometric analysis of global research trends.
    Negin Letafatkar, Amr Ali Mohamed Abdelgawwad El-Sehrawy, Kdv Prasad, Ahmad Alkhayyat, Ehsan Amini-Salehi, Maryam Hasanpour, Masoomeh Namdar Taleshani, Mohammad Hashemi, Hadi Alotaibi, Pegah Rashidian, Mohammad-Hossein Keivanlou, Soheil Hassanipour.
       Background: Artificial intelligence (AI) has revolutionized the field of gastroenterology, particularly in endoscopic and colonoscopic procedures. These AI technologies aim to enhance diagnostic accuracy by facilitating the detection of gastrointestinal lesions, such as polyps and neoplasms. However, the rapid expansion of research in this area necessitates a comprehensive analysis to assess global trends and contributions. This study aims to conduct a thorough bibliometric and visualization analysis of global research focused on AI applications in endoscopy and colonoscopy.
    Methods: A systematic search was conducted in September 2024 using the Web of Science Core Collection. The data were analyzed using VOSviewer, CiteSpace, and R software, focusing on co-authorship, co-citation, and keyword trends.
    Results: Research output on AI in endoscopy and colonoscopy has seen significant growth since 2016, peaking in 2023 with 345 publications. The top contributing country was China, with 399 publications, while the United States led in centrality with a score of 0.27, indicating its key position in research collaborations. Showa University contributed the highest number of institutional publications (64 papers). Mori Y emerged as the leading author, with 53 publications, reflecting his significant influence in the field. The leading journal was Gastrointestinal Endoscopy, contributing 72 publications and accumulating 6,496 citations. The most frequently occurring keywords were "diagnosis," "classification," and "cancer." The cluster analysis identified key research areas, with newer clusters emerging around "adenoma detection," "polyp segmentation," and "wireless capsule endoscopy." These clusters have shown an increasing trend over the past few years, reflecting the growing focus on using AI to optimize diagnostic procedures in real-time.
    Conclusion: The bibliometric analysis highlights the rapid expansion and diversification of AI research in endoscopy and colonoscopy. Key clusters, such as "adenoma detection" and "polyp segmentation," underscore the field's shift toward real-time diagnostic improvements. As AI technologies become more integrated into clinical practice, they are set to improve diagnostic accuracy and patient outcomes in gastroenterology.
    Keywords:  adenoma detection; artificial intelligence; bibliometric analysis; cancer; colonoscopy; diagnosis; endoscopy
    DOI:  https://doi.org/10.3389/fmed.2025.1532640
  33. Medicine (Baltimore). 2025 Jun 13. 104(24): e42747
    Frontier and hotspot evolution in pulmonary embolism: A bibliometric analysis from 2004 to 2023.
    Kaiyao Huang, Jianghua Zhu, Ke Sun, Heng Wang, Yun Peng, Bibo Peng.
      Pulmonary embolism (PE) is the third most common cause of cardiovascular death worldwide after stroke and heart attack. Research priorities in each PE period over the past 2 decades remain largely unassessed. This study aims to summarize PE research hotspots and trends using a bibliometric approach and predict future research hotspots. Relevant publications between 2004 and 2023 were extracted from the Web of Science Core Collection. Microsoft Excel 2016 and the R Bibliometrix package were used for descriptive and bibliometric data analyses. Country collaboration was visualized using VOSviewer. CiteSpace was used for the keyword burst analysis and timeline view construction. In total, 25,487 PE-related articles were included in the analysis. The annual number of publications followed a general upward trend. The USA was the most prolific country, with 9568 publications. The timeline of reference indicated 9 clusters including "#1 submassive PE," "#2 suspected PE," "#3 venous thromboembolism," "#4 direct oral anticoagulants," "#5 acute PE," "#6 cancer-associated thrombosis," "#7 medical patient," "#8 PE," and "#9 knee arthroplasty." The keyword "helical computed tomography" had the highest burst strength, followed by "unfractionated heparin," "society" and "molecular weight heparin." The keywords "direct oral anticoagulants," "venous thromboembolism," "american society," "society," "coronavirus disease 2019," "infection," "case report," "pneumonia" and "clinical characteristics" appeared frequently in recent years. Research on PE has focused on risk factor exploration, PE prevention and diagnosis, and then shifted to the treatment strategies, guideline updates, and specific types of PE. The use and feedback of guidelines, better improvement of prognosis, and life quality for PE-specific types might be potential future hotspots.
    Keywords:  CiteSpace; bibliometric; citations; guideline; pulmonary embolism
    DOI:  https://doi.org/10.1097/MD.0000000000042747
  34. Front Neurol. 2025 ;16 1455545
    Bibliometric analysis of research trends on hyperbaric oxygen therapy in stroke from 2000 to 2022.
    Mei Zhou, Xinxin Chen, Dan Li, Jiao Luo, Sihui Song, Jiuhong You, Hui Ma, Cheng Huang.
       Background: Stroke primarily results from the interruption of cerebral blood flow. Hyperbaric oxygen therapy (HBOT), a noninvasive and promising therapeutic intervention, has been widely used to treat various ischemic and hypoxic conditions. Over the past two decades, extensive research has demonstrated HBOT's efficacy in reducing cerebral infarct volume, establishing it as a viable neuroprotective strategy. Given these findings, this study employs bibliometric analysis to explore emerging trends and key research foci in HBOT applications for stroke management.
    Method: We performed a systematic literature search on hyperbaric oxygen therapy (HBOT) and stroke using the Web of Science Core Collection (WoSCC) database, specifically the Science Citation Index Expanded (SCI-Expanded). The search was restricted to English-language articles and reviews published between January 2000 and December 2022. Data retrieval, screening, and analysis were conducted in June 2023.
    Results: A total of 323 publications were identified, demonstrating annual fluctuations in research output. The United States dominated HBOT-related stroke research in both publication volume and scientific impact. Shai Efrati emerged as the most prolific author in this field, while the Sackler Faculty of Medicine at Tel Aviv University was the most influential institution. The journal Stroke published the highest number of HBOT-related stroke studies. Co-citation analysis revealed "cognitive function" as the primary research focus in HBOT applications for stroke.
    Conclusion: This bibliometric analysis investigated the current research landscape, trends, and emerging priorities in hyperbaric oxygen therapy (HBOT) applications for stroke. The primary research focus centered on HBOT's therapeutic potential for cognitive function enhancement and chronic-phase post-stroke treatment.
    Keywords:  HBOT; bibliometric analysis; hyperbaric oxygen therapy; research trends; stroke
    DOI:  https://doi.org/10.3389/fneur.2025.1455545
  35. Subst Abuse Treat Prev Policy. 2025 Jun 14. 20(1): 25
    Smoking and bladder cancer: insights into pathogenesis and public health implications from a bibliometric analysis (1999-2023).
    Yang Wang, Hancheng Zhou, Zhicheng Tang, Zhaohui He, Hui Zhuo, Yi Huang, Jianqiu Kong.
       BACKGROUND: Cigarette smoking is a major contributor to the global burden of bladder cancer. Its carcinogenic effects result from the harmful substances in tobacco smoke, which induce genetic mutations and disrupt cellular processes. Understanding how smoking contributes to bladder cancer is essential for developing effective prevention and treatment strategies.
    OBJECTIVE: This study systematically reviews global research on the relationship between smoking and bladder cancer through bibliometric analysis, identifying research hotspots, trends and future directions.
    METHODS: Relevant literature on the relationship between cigarette smoking and bladder cancer published between 1999 and 2023 was retrieved from the Web of Science database. Visual analyses were conducted using VOSviewer and CiteSpace software, focusing on contributions from countries, institutions, journals, authors and keywords.
    RESULTS: Our analysis of 2,802 publications revealed an upward trend in annual output on the relationship between smoking and bladder cancer, with the United States and China as leading contributors. Notable institutions included the NIH, National Cancer Institute, University of Texas System and the International Agency for Research on Cancer. Key journals were Cancer Epidemiology, Biomarkers & Prevention and International Journal of Cancer. Rothman, Nathaniel and Zeegers, M.P.A. were the most productive and co-cited authors. Keyword analysis highlighted DNA repair, genome-wide association studies, and smoking cessation.
    CONCLUSION: This bibliometric analysis has significantly advanced the field by highlighting current research directions and the application of specific mechanisms. These findings also have implications for clinical practice and public health policy, potentially improving patient outcomes through a comprehensive understanding of disease pathogenesis.
    Keywords:  Bibliometrics; Bladder cancer; Citation analysis; International collaboration; Smoking
    DOI:  https://doi.org/10.1186/s13011-025-00658-6
  36. Interact J Med Res. 2025 Jun 20. 14 e67276
    Characterization of Global Research Trends and Prospects on Prone Positioning in Respiratory Failure: Bibliometric Analysis.
    Rong Lei, Feng Yue, Chaofu Yue, Zihan Zhang, Xian Huang, Qiaolin Li, Zhigang Yang, Rong Li, Keyi Zhao, Mei Yang.
       Background: Prone positioning has emerged as a crucial intervention in managing acute respiratory failure, especially in acute respiratory distress syndrome and patients with COVID-19. Given the increasing interest in this field, it is important to characterize global research trends and key contributors to identify future research directions.
    Objective: This study aimed to analyze global research trends, collaboration networks, and research hotspots related to prone positioning in respiratory failure through a comprehensive bibliometric analysis.
    Methods: Bibliometric analyses were conducted using CiteSpace and Biblioshiny software on publications up to December 31, 2023, from the Web of Science Core Collection, focusing on prone positioning in respiratory failure.
    Results: A total of 1263 research articles were identified, published in 50 countries by numerous institutions. The United States, France, and Germany contributed the most publications, with the United States producing 21.9% (275/1263) of the total. Key authors such as Claude Guerin and Luciano Gattinoni were identified as major contributors to the field. Keyword co-occurrence analysis revealed the dynamic nature of prone positioning research in respiratory failure. It highlighted protective ventilation and COVID-19-related acute respiratory distress syndrome as emerging hotspots, indicating a shift in focus during the pandemic.
    Conclusions: This study revealed a rapidly growing body of literature on prone positioning in respiratory failure, especially in the context of COVID-19. The findings underscore the importance of further multicenter clinical trials to validate current practices and refine treatment protocols. In addition, the application of prone positioning in non-intubated patients represents a potential future research direction.
    Keywords:  ARF; COVID-19; SARS-CoV-2; acute respiratory distress syndrome; acute respiratory failure; bibliometric analysis; bibliometrics; coronavirus; critical care; infectious; lungs; pandemic; prone positioning; pulmonary; respiratory failure
    DOI:  https://doi.org/10.2196/67276
  37. Front Neurol. 2025 ;16 1540083
    Tracing inflammasomes in Alzheimer's: insights from bibliometric analysis.
    Yingjun Chen, Hui Pei, Hao Li, Wenjun Zeng, Zhitao Li.
       Background: Alzheimer's disease is one common type of dementia. Numerous studies have suggested a correlation between Alzheimer's disease and inflammation. The inflammasome is the core of the inflammatory response and plays an important role in the inflammatory response. Currently, ample evidence has shown that inflammasomes are closely related to the occurrence and development of Alzheimer's disease.
    Objective: To explore the evolution and development trends of inflammasomes in Alzheimer's disease using bibliometric and knowledge mapping analysis. By identifying research hotspots and emerging topics, we aim to provide new insights and directions for researchers in this field.
    Methods: All data related to inflammasomes in Alzheimer's disease from 2000 to 2024 were collected from the Web of Science Core Collection (WoSCC), and annual publications, national publication trends, and proportion charts were analyzed and plotted using GraphPad price v8.0.2. Additionally, CiteSpace (6.2.4R (64-bit) Advanced Edition), and VOSviewer (version 1.6.18) were used to analyze and visualize these data.
    Results: A total of 1,128 publications related to the inflammasome in Alzheimer's disease were recorded in the WoSCC, comprising 738 articles and 390 reviews. The literature was mainly from 68 countries/regions and 1,545 institutions, particularly China (n = 464) and the USA (n = 266). Despite China's leading in publication quantity, the United States holds a prominent position in the field due to the higher quality of its scholarly articles. The institution that contributes the most publications is the Helmholtz Association. JOURNAL OF MOLECULAR SCIENCES was a prolific contributor, and Nature was the most frequently cited journal. Keyword analysis showed that nlrp3 inflammasome, neuroinflammation, microglia activation, and amyloid-beta were the most common terms, reflecting the main research interests in currently published papers in this field. Research in this field primarily focuses on the NLRP3 inflammasome, which is closely associated with pathological products like Aβ and tau proteins. It can induce pyroptosis and accelerate the progression of Alzheimer's disease.
    Conclusion: The NLRP3 inflammasome is critical in Alzheimer's disease (AD) pathogenesis. However, the peak of related literature was in 2023, suggesting a potential decline in this research hotspot. There is an urgent need to explore new pathogenic mechanisms for AD. Clearly, this is an important direction that requires deep thinking and breakthroughs.
    Keywords:  Alzheimer’s disease; CiteSpace; VOSviewer; bibliometrics; inflammasome
    DOI:  https://doi.org/10.3389/fneur.2025.1540083
  38. Urolithiasis. 2025 Jun 16. 53(1): 116
    Global research trends in minimally invasive treatments for kidney stones: A bibliometric analysis (2015-2024).
    Tunahan Ates, Ibrahim Halil Sukur, Fesih Ok, Mehmet Gurkan Arikan, Nebil Akdogan.
      The prevalence of kidney stone disease has been increasing globally, resulting in a rise in minimally invasive treatment methods. Percutaneous nephrolithotomy (PCNL), retrograde intrarenal surgery (RIRS), extracorporeal shock wave lithotripsy (SWL), and endoscopic combined intrarenal surgery (ECIRS) have become standard procedures. This study aims to evaluate global publication trends in this field over the last decade. A bibliometric analysis was conducted using the Web of Science Core Collection database. A total of 3,693 articles published between 2015 and 2024 were analyzed. VOSviewer and Bibliometrix R package were used for data visualization, which included co-authorship networks, keyword co-occurrence analysis, and thematic evolution mapping. However, this analysis did not differentiate between various author roles, which may have influenced the perceived scientific impact of certain researchers, potentially favoring those with strong political or organizational affiliations. China, Turkey, and the USA were the top contributors to publications, with the USA ranking first in total citations. The number of studies has significantly increased over the past decade, indicating a growing trend. The most studied procedures were PCNL and related techniques, followed by RIRS, which has become more popular due to advancements in laser technology and flexible ureteroscopy. Thematic analysis identified trends in postoperative outcomes, complication management, and predictive models for treatment success. Thematic evolution mapping showed a decline in SWL studies, but an increase in interest in ECIRS and multimodal approaches. Minimally invasive kidney stone treatments have advanced significantly, with PCNL remaining the gold standard for large stones and RIRS emerging as a competitive alternative. Future research should focus on optimizing surgical outcomes, integrating AI-based decision support systems, and expanding international collaborations to enhance patient care.
    Keywords:  Bibliometric analysis; ECIRS; Kidney stone; PCNL; RIRS; SWL
    DOI:  https://doi.org/10.1007/s00240-025-01785-2
  39. J Multidiscip Healthc. 2025 ;18 3373-3390
    A Bibliometric Analysis of Research Trends in Spousal Support for Breast Cancer Patients.
    Yanping Liu, Yanxue Zhai, Limei Gao, Gantang Zhang.
       Background: The annual rise in breast cancer incidence is a significant issue that threatens women's health and imposes various physical and psychological effects on male spouses, while these spouses often serve as the primary source of social support for patients.
    Purpose: To conduct a systematic analysis of publications, countries, institutions, journals, disciplines, authors, keywords, and references related to spousal support for breast cancer patients using bibliometric methods.
    Methods: We searched the Web of Science Core Collection (WOSCC) for publications related to spousal support for breast cancer patients from January 2004 to December 2024. CiteSpace (6.4 R1, 64-bit Advanced Edition) and Microsoft Office Excel 2019 were used for bibliometric analysis and chart generation.
    Results: Our study analyzed 672 articles in the WOSCC database on spousal support for breast cancer patients over the past two decades. These publications have exhibited a trend of fluctuating growth. Research area primarily focuses on oncology, psychology, and nursing, with findings mainly published in Psycho-Oncology and Supportive Care in Cancer. The United States, Canada, and Australia lead this research domain, with the University of California system, Duke University, and Harvard University being the principal research institutions. Laura S. Porter and Donald H. Baucom are among the most prolific authors. The main keyword clusters include #1 caregiving burden, #2 quality of life, #3 sexual health, #4 qualitative study, #5 dyadic coping, and #6 marital status. The references focus on social psychology, intimate relationships, emotional communication, and coping interventions.
    Conclusion: This bibliometric study analyzes research on spousal support for breast cancer patients during the last two decades, outlining the publications, countries, institutions, journals, disciplines, and authors that have significantly influenced the field. Emerging trends in research on spousal support for breast cancer patients emphasize valuing the caregiving burden endured by spouses, exploring their support experiences, identifying spousal support barriers, and addressing intimacy challenges.
    Keywords:  breast cancer; cite space; research hotspots; review; spouse support; visual analysis
    DOI:  https://doi.org/10.2147/JMDH.S476838
  40. Medicine (Baltimore). 2025 Jun 13. 104(24): e42756
    Lower-limb locomotor function studies using walking speed as an assessment indicator: A bibliometric review from 2014 to 2024.
    Luming Yang, Yuan Liu, Mei Wu, Xinye Liu, Longbin Zhang, Shiyang Yan.
       BACKGROUND: Walking speed is an important kinematic parameter for evaluating lower-limb locomotor function. Our review aims to identify the research trends and hotspots of walking speed in assessing mobility across various populations through bibliometric methods.
    METHODS: A total of 1656 articles on the topic of walking speed published between 2014 and 2024 were retrieved from the Web of Science core database. CiteSpace was used for bibliometric visualizations, analyzing key indicators, such as the number of annual publications and their citation frequency, institutions, research areas, co-cited references, keywords, and other indicators.
    RESULTS: The number of studies on walking speed has consistently increased in the past decade. The University of Delaware publishes the most articles (37 articles). Research areas indicate that walking speed has been widely used in orthopedics, neuroscience, and rehabilitation. Recent studies are closely associated with gait analysis, aging, and youth populations through co-cited reference analysis. Moreover, keyword results show that knee osteoarthritis, physical activity, and muscle strength are the primary research topics. Body function and sex differences have become the latest research hotspots.
    CONCLUSION: Walking speed is widely used to evaluate the activity ability of people with movement disorders and their exercise rehabilitation effect, especially in older adults. We hope to provide an overview of walking speed research for researchers in geriatrics, rehabilitation medicine, and biomedical engineering, encouraging them to focus on analyzing the relationship between walking speed and the mechanism of musculoskeletal system movement in future studies.
    Keywords:  aging; knee osteoarthritis; lower-limb locomotor function; rehabilitation training; walking speed
    DOI:  https://doi.org/10.1097/MD.0000000000042756
  41. Hum Vaccin Immunother. 2025 Dec;21(1): 2518634
    A bibliometric analysis of challenges and advancements in the integrated application of nanoparticles and chimeric antigen receptor T cell therapy.
    Yang Gao, Yang Zhou, Xiaolin He, Hongwei Lin, Keying Fang, Qijun Hou, Huafang Wang, Honghao Zhang, Yixi Zhang, Yuhua Li.
      In recent years, the integration of nanoparticles with chimeric antigen receptor T-cell (CAR-T) therapy has advanced rapidly, garnering considerable attention from both academic and industrial sectors. However, a comprehensive analysis of key trends and emerging frontiers in this interdisciplinary field remains lacking. To address this gap, we conducted a bibliometric analysis of 515 publications indexed in the Web of Science Core Collection from 2013 to 2024. Using VOSviewer, CiteSpace, and R-bibliometrix, we analyzed publication trends, influential journals, national and institutional contributions, leading authors, and high-impact references. Keyword co-occurrence analyses were performed in VOSviewer, applying a minimum occurrence threshold of five. Citation bursts and clustering analyses of references and keywords were conducted using CiteSpace with default detection settings. Our analysis revealed major research hotspots, especially the optimization of CAR-T cell manufacturing processes and strategies to overcome barriers within the immunosuppressive tumor microenvironment. Looking forward, research is expected to focus increasingly on nanotechnologies such as lipid nanoparticles, precision cell tracking, and siRNA delivery platforms. These innovations hold substantial promise for enhancing the therapeutic efficacy of CAR-T therapies, particularly in the treatment of solid tumors, where conventional approaches remain inadequate. By identifying emerging directions and influential research trends, our analysis highlights the dynamic synergy between nanoparticles and CAR-T therapies, helping to fuel groundbreaking advances in tumor immunotherapy. This study provides data-driven insights that inform clinical trial design, foster interdisciplinary collaboration, and demonstrate the field's strong potential to transform future cancer treatment paradigms.
    Keywords:  Chimeric antigen receptor T cell therapy; bibliometrics; cell engineering; nanoparticle; tumor immunotherapy; tumor microenvironment
    DOI:  https://doi.org/10.1080/21645515.2025.2518634
  42. Naunyn Schmiedebergs Arch Pharmacol. 2025 Jun 18.
    Emerging trends in anticoagulation therapy: a bibliometric analysis of DOACs and endogenous coagulation pathway inhibitors.
    Zhe Zhu, Rong Huang, Hongli He, Rong Zhao, Xirui Li, Fangyan He, Dan Luo.
      The emergence of direct oral anticoagulants (DOACs) has revolutionized the landscape of anticoagulation, while emerging targeted inhibitors of endogenous coagulation pathways have introduced novel dimensions to anticoagulant therapy. This study aimed to systematically characterize the evolving research landscape through a comprehensive bibliometric analysis, elucidating historical development, research hotspots, and emerging trends in this field. A total of 1993 relevant publications (1990-2024) was systematically retrieved from the Web of Science Core Collection. The bibliometric tools including CiteSpace and HistCite were employed to perform the analysis of historical characteristics, evolution analysis of active topics, and identification of emerging trends. The number of articles in this field was growing rapidly, with the USA, China, and Canada emerging as predominant contributors. Moreover, four principal investigators demonstrated sustained academic dominance through high publication output: Zhao Jinhua, Lip Gregory Y.H., Weitz Jeffrey I., and Gao Na. Three distinct research frontiers were identified, including clinical application and medication safety of DOACs, therapeutic potential of factor XI inhibitors for thrombosis prevention with reduced bleeding risks, and the exploration of fucosylated chondroitin sulfate as a novel iXase-targeting anticoagulant. This study presents a systematic review of DOACs and inhibitors targeting endogenous coagulation pathways in antithrombotic therapy. By identifying current research priorities and emerging trends, this analysis serves as an invaluable resource to guide scholars in recognizing novel therapeutic targets and advancing the development of next-generation anticoagulant drugs.
    Keywords:  Anticoagulation; Direct oral anticoagulants; Endogenous coagulation pathways; Factor XI; Intrinsic Xase
    DOI:  https://doi.org/10.1007/s00210-025-04352-z
  43. Front Digit Health. 2025 ;7 1582719
    The evolution of digital health: a global, Latin American, and Brazilian bibliometric analysis.
    Maria Eulália Vinadé Chagas, Gabriela de Oliveira Laguna Silva, Gabriel Ricardo Fernandes, Gabriela Tizianel Aguilar, Mariana Motta Dias da Silva, Evandro Luis Moraes, Isadora D Avila Lottici, Jerusa da Rosa de Amorim, Tiago de Abreu, Taís de Campos Moreira, Felipe Cezar Cabral.
       Introduction: Digital health provides remote healthcare assistance, contributing to reducing inequalities in access to services. For its widespread adoption, it is essential to disseminate successful models implemented in countries with developed digital health networks, so that they can be adapted and replicated in developing regions. The dissemination of scientific studies on the topic, combining digital health activities within various contexts with scientific research, is crucial for promoting significant advancements in the understanding and application of these technologies. This study aims to conduct a comprehensive bibliometric analysis of global scientific production in digital health from 2019 to 2024, with special attention to Latin America and Brazil.
    Methods: A bibliometric analysis was conducted with searches in PubMed, Scopus, and Web of Science. The analysis used the Bibliometrix package in RStudio, and the data were filtered for the global dimension, Latin American countries, and Brazil. The authorship analysis was restricted to publications with at least one Brazilian author and was carried out through a manual check of each record. The protocol was registered on the Open Science Framework platform under the number 10.17605/OSF.IO/43WQ5.
    Results: A total of 51,723 publications were included in the global dimension, 2,410 in Latin America, and 1,317 in the Brazilian analysis. The number of publications increased from 2019 to 2021. In the global scenario, the United States led scientific production in digital health, whereas Brazil led in Latin America.
    Conclusion: Digital health has expanded exponentially, consolidating itself as a strategic pillar in healthcare systems. Investments in international collaborations that encourage knowledge exchange, strengthen research networks, and drive scientific publications are essential. These partnerships are crucial for adapting digital tools to different socioeconomic contexts and ensuring equitable care for the population.
    Keywords:  Brazil; Latin America; bibliometric analysis; digital health; telemedicine
    DOI:  https://doi.org/10.3389/fdgth.2025.1582719
  44. JPRAS Open. 2025 Sep;45 76-88
    Comprehensive bibliometric and visualized analysis of research on incisional hernia and component separation from 1996 to 2023.
    Mohamed Maatouk, Imen Maatouk, Ghassen Hamdi Kbir, Ons Hmandi, Mariem Nouira, Mohamed Ben Khalifa.
       Introduction: In parallel with the increasing number of studies published on component separation technique (CST), there are no bibliometric studies on this subject. This study aimed to report previously published literature in CST to identify the research status.
    Methods: A search was undertaken for documents published between 1996 and 2023 from the PubMed, Web of Science, and Scopus databases, using the keywords "incisional hernia" and "component separation."
    Results: A total of 469 publications was found from 121 different journals. The USA was in the leading position in several fields (productive authors, active institutions, and international cooperation).CST was predominantly published in plastic surgery journals; however, after more specialized journals on topics such as Hernia became predominant, dominating the number of publications since 2013. "Transversus Abdominis Release" and "minimally invasive" have been trending keywords in recent years.
    Conclusion: Although CST research on incisional hernia repair has witnessed notable growth, publications in plastic surgery journals have declined. We encourage these journals to highlight the critical role of plastic surgery and the importance of collaboration between general and plastic surgeons worldwide, focusing on minimally invasive techniques to establish robust evidence for the standard repair of large abdominal wall defects.
    Keywords:  Bibliometric analysis; Incisional hernia -Component separation
    DOI:  https://doi.org/10.1016/j.jpra.2025.04.012
  45. Front Digit Health. 2025 ;7 1528711
    Digital horizons in non-communicable disease care: a bibliometric exploration of intervention impact and innovation.
    Sudip Bhattacharya, Alok Singh, Akanksha Kashyap.
       Introduction: Digital interventions show considerable promise in managing non-communicable diseases (NCDs) within primary healthcare.
    Aim: The aim of this study was to conduct a comprehensive bibliometric analysis of research on digital interventions for individuals living with NCDs.
    Methodology: This study explores digital interventions in NCDs through a bibliometric analysis from 2014 to 2024. Carefully designed search queries targeted primary and combined terms to cover a wide range of NCDs, including cancer, diabetes, and hypertension. SCOPUS searches yielded 9,572 English-language articles, refined by excluding non-relevant works and duplicates. Metadata, including authorship, keywords, and citations, was extracted for analysis. Using Biblioshiny and VosViewer, the study examined publication trends, telemedicine applications, and the knowledge framework of the field. Conceptual themes were identified through co-occurrence mapping, intellectual structures via co-citation networks, and social structures through collaboration patterns among authors, institutions, and countries.
    Results: The upward trend in research on digital interventions and NCDs accelerated significantly after 2018, peaking in 2021, followed by a slight decline. Medicine dominates this field, with considerable contributions from biochemistry, health professions, and engineering. The most prolific authors, primarily from the United States, United Kingdom, and Australia, have significantly shaped this research area. Institutional contributions are led by Harvard Medical School and other global leaders, reflecting strong inter-institutional collaborations. The United States and the United Kingdom are the most productive countries, with the Journal of Medical Internet Research standing out as the leading publication. Keyword analysis reveals a focus on telemedicine, COVID-19, tele-health, and digital health. Co-citation analyses identify key intellectual frameworks, while co-authorship and institutional collaborations highlight robust global networks. Emerging trends emphasize AI, digital health tools, and patient self-management, underscoring a transformative shift in addressing NCDs through technology-driven interventions. The findings highlight the need for patient-centered applications, improved implementation strategies, and strengthened collaborations, especially in underrepresented regions, to enhance the global impact of digital interventions for NCDs.
    Keywords:  chronic disease; digital health; health information systems; m-Health (Mobile health); non-communicable diseases; telemedicine
    DOI:  https://doi.org/10.3389/fdgth.2025.1528711
  46. World J Transplant. 2025 Jun 18. 15(2): 99992
    COVID-19's impact on heart and lung transplantation: Citation-based analysis of research output.
    Nisreen Yaghmour, Dina Alramini, Mohammad Alsarayrah, Mohammad Abuassi, Awn Al-Rameni, Mohammad Aladaileh, Haneen Al-Abdallat, Badi Rawashdeh.
       BACKGROUND: Since being declared as a pandemic on March 11, 2020, coronavirus disease 2019 (COVID-19) has profoundly influenced heart and lung transplant programs, impacting donor availability, patient management, and healthcare resources. This study offers a citation-based review of the research output on this subject, seeking to understand how the transplant community has responded to these challenges. Through a review of literature from the beginning of the pandemic to early 2023, we evaluate the shifts in academic emphasis and the emerging trends in heart and lung transplantation during the COVID-19 period.
    AIM: To assess the impact of COVID-19 on heart and lung transplantation research, highlighting key themes, contributions, and trends in the literature during the pandemic.
    METHODS: We conducted an extensive search of the Web of Science database on February 9, 2023. We employed the terms "transplant" and "transplantation", as well as organ-specific terms like "heart", "cardiac", and "lung", combined with COVID-19-related terms such as "COVID-19", "coronavirus", and "SARS-CoV-2". The search encompassed publications from March 11, 2020 to February 9, 2023. Data on authors, journals, countries, institutions, and publication types (articles, reviews, conference papers, letters, notes, editorials, brief surveys, book chapters, and errata) were analyzed. The data was visualized and processed with VOSviewer 1.6.18 and Excel.
    RESULTS: We included 847 research items. There were 392 articles (46.3%) and 88 reviews (10.3%). The studies included were referenced 7757 times, with an average of 9.17 citations per article. The majority of the publications (n = 317) were conducted by institutes from the United States with highest citations (n = 4948) on this subject, followed by Germany, Italy, and France. The majority of papers (n = 101) were published in the Journal of Heart and Lung Transplantation.
    CONCLUSION: To the fullest extent of our knowledge, this is the first bibliometric study of COVID-19's impact on heart and lung transplantation to offer a visual analysis of the literature in order to predict future frontiers and provide an overview of current research hotspots.
    Keywords:  Bibliometric analysis; COVID-19; Heart transplant; Lung transplant; Pandemic
    DOI:  https://doi.org/10.5500/wjt.v15.i2.99992
  47. Front Microbiol. 2025 ;16 1564717
    Research focus and trends of the association between gut microbiota and neuroinflammation.
    Shan Wu, Nanjie Chen, Chuanchi Wang, Kwok-Fai So.
       Background: The interaction between the gut microbiota and neuroinflammation plays a crucial role in the pathogenesis of many diseases, particularly neurodegenerative diseases, and has become one of the focal points of research in recent years. Despite the large number of related studies, there is currently a lack of comprehensive analysis and prediction of these data to drive the field forward. This study aims to systematically analyze the clinical practices and research hotspots of the underlying mechanisms in this field using bibliometric and visualization methods, and to explore the future development pathways.
    Methods: CiteSpace, VOSviewer, GraphPad Prism and other software were used to analyze 1,404 studies on gut microbiota and neuroinflammation collected by the core of the Web of Science since 2000, to visually present the collaborative network between literatures, structure of authors and countries, co-occurrence of keywords, emerging reference literature, and research hotspots.
    Results: From 2000 to 2024, the number of related papers on this topic showed an overall upward trend, and the annual citation peaked in 2020, with significant contributions from China and the United States. Research focused on the relationship between gut microbiota and neuroinflammation, with a particular emphasis on investigating the mechanisms of the microbiota-gut-brain axis through both basic and clinical research. Treatment strategies include probiotic therapy, fecal microbiota transplantation and traditional Chinese medicine.
    Conclusion: This study comprehensively reviews the research progress on the association between gut microbiota and neuroinflammation, and discusses the current research focus and frontier directions of this relationship, so as to provide reference for the development of this field.
    Keywords:  bibliometric analysis; gut microbiota; neurodegenerative; neuroinflammation; research trends
    DOI:  https://doi.org/10.3389/fmicb.2025.1564717
  48. Front Med (Lausanne). 2025 ;12 1595060
    Exploring the growth and impact of artificial intelligence in anesthesiology: a bibliometric study from 2004 to 2024.
    Keke Liu, Weicheng Qiu, Xinping Yang.
       Background: The integration of artificial intelligence (AI) in anesthesiology is revolutionizing clinical practice by enhancing patient monitoring, improving risk assessment, and enabling personalized anesthetic care. This bibliometric analysis aims to evaluate publication trends, key contributors, and emerging translational pathways in AI research in anesthesiology, with special emphasis on clinical relevance, thematic clustering, and future application prospects.
    Materials and methods: Publications related to AI in anesthesiology from 2004 to 2024 were retrieved from the Web of Science Core Collection database, resulting in 658 articles. VOSviewer and CiteSpace were employed for the bibliometric analysis.
    Results: AI research in anesthesiology has experienced substantial growth, with a notable surge between 2019 and 2020. The United States leads in both publication volume and citation impact, reflecting its central role in advancing AI-driven innovations. Major journals such as Anesthesia and Analgesia and Anesthesiology play central roles in disseminating key findings. Keyword and journal cluster analyses revealed three major translational domains: real-time perioperative risk prediction (e.g., hypotension, mortality), AI-assisted ultrasound for regional anesthesia, and intelligent anesthesia monitoring systems. Despite progress, emerging concerns such as model interpretability, patient-centered outcomes, and multimodal data integration remain underexplored.
    Conclusion: AI in anesthesiology is entering a phase of rapid interdisciplinary expansion, integrating clinical needs with computational innovation. Future research should prioritize the clinical validation of AI tools, foster stronger collaboration between computer scientists and anesthesiologists, and address unresolved translational gaps such as model interpretability and cross-modal data fusion.
    Keywords:  CiteSpace; VOSviewer; bibliometric analysis; intraoperative monitoring; predictive modeling
    DOI:  https://doi.org/10.3389/fmed.2025.1595060
  49. Discov Oncol. 2025 Jun 19. 16(1): 1151
    Publication trends and hotspots for cervical cancer screening biomarker: a bibliometric analysis.
    Jia Xu, Wen Yang, Liangying Liu, Shuting Zhou, Xiangshu Jin, Min Zhao, Miao Liu, Yuanguang Meng.
       BACKGROUND: The global disease burden of cervical cancer has remained significant throughout history. It is essential to discover sensitive and specific biomarkers for cervical cancer screening to enhance its quality and efficiency. This study aimed to delineate the publication trends and hotspots for cervical cancer screening biomarker through a bibliometric analysis. Therefore, researchers could acquire a comprehensive understanding of this area.
    METHODS: Professional search strategies were employed to collect literatures, with the central keywords being cervical cancer screening biomarker. Publications were retrieved from CBM/CNKI/Wanfang databases in Chinese and WoSCC/Pubmed databases in English. After being reviewed by two researchers, the publication dataset was analyzed in terms of sources, countries, authors, journals, citations and keywords using Citespace and bibliometrix package in the R environment.
    RESULTS: 547 publications of Chinese origin and 1068 of English origin were picked out. China, the USA and the Netherlands were the most contributing countries. Professor Meijer was the most outstanding author. There is a need to publish articles on our targeted topic in journals with greater academic influence. Current published literatures predominately focused on "p16(ink4a) protein", "DNA methylation" and "human papillomavirus". It has been popular in recent years to identify hub genes as candidate biomarkers through bioinformatics analysis.
    CONCLUSIONS: It is a challenge to discover a novel and convenient biomarker to simplify the cervical cancer screening process. Global collaboration and clinical trials in high-incidence countries may contribute to the advancement of biomarker research. HPV testing, p16(ink4a) protein and DNA methylation used to be research hotspots, and they are now applied in clinical practice. Cervico-vaginal microbiota and bioinformatics analysis are the new keywords that have emerged recently.
    Keywords:  Bibliometrics; Biomarker; Cervical cancer; Screening
    DOI:  https://doi.org/10.1007/s12672-025-02936-y
  50. Fam Med. 2025 Jun 04.
    A Descriptive Bibliometric Study of CERA Publication Dissemination, Authorship, and Citation Rates.
    Bryce A Ringwald, Jennifer L Middleton.
       BACKGROUND AND OBJECTIVES: Barriers to performing family medicine research include funding, infrastructure, and mentorship shortages. The Council of Academic Family Medicine Educational Research Alliance (CERA) was created in 2011 to address these issues. This study explores the scope and impact of CERA-related publications in family medicine.
    METHODS: We performed a descriptive bibliometric study of CERA-related publications from 2011 to 2023. Articles were sourced from Medline (PubMed), SCOPUS, and the CERA website. Data analysis focused on publication type, authors, CERA survey type, and citation rates.
    RESULTS: From a total of 231 articles retrieved via initial searches and 166 from the CERA website, 174 were included in the analysis. Most studies (95.4%) were original research, with the journal Family Medicine publishing the majority (69.4%). General membership surveys had the highest citations per publication (6.3), while publications prior to 2017 had more citations on average (6.3) compared to those after 2017 (2.4). CERA-related publications featured 515 unique authors across 153 affiliations, with top contributors being Kelly Everard and Arch Mainous III.
    CONCLUSIONS: CERA provides essential infrastructure for family medicine research, fostering diversity in authorship and affiliations. While impactful in family medicine journals, opportunities exist to extend CERA's reach. Continued support and enhancements in data use are both needed.
    DOI:  https://doi.org/10.22454/FamMed.2025.354255
  51. Front Microbiol. 2025 ;16 1574802
    Bacillus cereus in food safety: a bibliometric analysis.
    Muhammad-Ehtesham Abdul, Enrico Pavoni.
      Bacillus cereus, a spore-forming pathogen, poses significant food safety risks due to its prevalence in diverse food matrices and ability to produce emetic and diarrheal toxins. This study presents the first bibliometric analysis of global research on B. cereus in food safety, examining 898 Scopus-indexed articles (2000-2024). Data were extracted using the search query "Bacillus cereus" OR "B. cereus" AND "Food Safety" in titles/abstracts, followed by quantitative and visual analyses via VOSviewer and the bibliometrix R-package. Metrics included annual growth rates, citation trends, country/institution contributions, and keyword co-occurrence. Collaborative networks and author productivity were mapped using co-authorship analysis. Results revealed an 8.29% annual publication growth, with China (38.86%), South Korea (22.05%), and the United States (18.26%) as leading contributors. Citation analysis highlighted seminal works on pathogenicity (e.g., enterotoxins, antimicrobial resistance), while keyword co-occurrence identified emerging themes such as virulence genes, cereulide, and sustainable mitigation strategies (e.g., probiotics, bacteriocins). Critical gaps persist in understanding B. cereus behavior in novel food matrices (e.g., plant-based alternatives) and the efficacy of emerging preservation technologies. This analysis underscores the need for interdisciplinary approaches integrating genomics, food science, and public health to address risks in global supply chains. The findings provide a roadmap for future research, advocating for advanced surveillance, innovative interventions, and policy refinement to combat this resilient pathogen.
    Keywords:  VOSviewer; antimicrobial resistance; bibliometric analysis; cereulide; foodborne pathogens
    DOI:  https://doi.org/10.3389/fmicb.2025.1574802
  52. Front Immunol. 2025 ;16 1579924
    Unveiling the role of NAD glycohydrolase CD38 in aging and age-related diseases: insights from bibliometric analysis and comprehensive review.
    Xianghui Zhao, Peiying Lv, Zixing Cai, Jun Dong, Wenxiang Chen, Liang Sun, Ruiyue Yang.
       Background: CD38, a glycoprotein with a single transmembrane structure, is extensively found in erythrocytes, immune cells, and endothelial cells. Primarily located on cell membranes, it plays a critical role in metabolizing nicotinamide adenine dinucleotide (NAD), thereby maintaining NAD homeostasis in vivo. As a vital coenzyme, NAD is involved in numerous biological processes, including energy metabolism, apoptosis, and DNA repair. CD38, as a major NAD-depleting enzyme, is pivotal in regulating intracellular NAD levels and various physiological processes. Given its significance, understanding the function of CD38 and its implications in aging and age-related diseases is crucial for elucidating disease pathogenesis and developing therapeutic strategies.
    Methods: This study conducted a bibliometric analysis to explore recent research trends and advancements in the field of CD38. Research articles were retrieved from the Web of Science database, followed by a bibliometric assessment using CiteSpace and VOSviewer to visualize key publication trends, contributions by countries and institutions, and keyword distributions. Based on the bibliometric analysis, key insights were synthesized to elucidate the role of CD38 in aging and age-related diseases, its underlying mechanisms, and its applications in clinical evaluation, detection methods, interventions, and therapeutic targets.
    Results: The bibliometric analysis revealed an exponential increase in the number of published articles over time, with the United States and China emerging as the leading research hubs. The predominant keywords included 'CD38' and 'blood-related disorders'. Furthermore, key findings highlighted the critical role of CD38 in aging and age-related diseases, emphasizing its mechanisms in NAD metabolism and its potential as a therapeutic target. Moreover, current applications of CD38 in clinical evaluation and detection methods were discussed, showcasing its growing importance in biomedical research.
    Conclusion: This study underscores the growing interest in CD38 research, particularly its role in aging and age-related diseases. The findings highlight the significance of CD38 in maintaining NAD homeostasis and its potential as a therapeutic target. The exponential growth in publications and the dominance of the United States and China in this field reflect the global importance of CD38 research. Future studies should further explore the mechanistic insights and clinical applications of CD38 to advance therapeutic strategies for age-related diseases.
    Keywords:  CD38; aging; bibliometric analysis; metabolic diseases; tumors
    DOI:  https://doi.org/10.3389/fimmu.2025.1579924
  53. Front Med (Lausanne). 2025 ;12 1583173
    Research hotspots and trends on illicit drugs: a bibliometric and visualized analysis.
    Yinyu Chen, Gaolin Zheng, Xinyan Yang, Guangmei Wu, Qianyun Nie, Peng Zhang.
       Objective: To explore the current status and developmental trend of drug research in the international arena through bibliometric methods and visualization analysis.
    Methods: In this study, drug-related articles published from 2015 to 2024 in the core collection of Web of Science databases were analyzed, and bibliometric and visualization analyses of annual publication volume, countries (regions), institutions, journals, and keywords were achieved using CiteSpace v.6.2.R7 software.
    Results: A total of 5,797 publications on drug research were included between 2015 and 2024, with the annual publication volume progressively increasing on an annual basis. Among the 117 publishing countries (regions), the United States published the most articles, with 1,534 publications, followed by the United Kingdom with 611 articles. Additionally, the literature was sourced from 1,441 journals, with a total of 1,398 publications in the top 10 journals. DRUG TESTING AND ANALYSIS ranked first with 259 articles. Finally, keyword clustering and emergence analysis revealed that current research hotspots were concentrated in the areas of drug abuse, new psychoactive substances, synthetic drugs, and wastewater treatment.
    Conclusion: The volume of drug-related research publications is steadily increasing globally. However, there is a pressing need to further strengthen global collaboration and interdisciplinary research, as well as to promote the development of a broader international scientific research network. In particular, advanced technological approaches and policy strategies must be explored to address the global challenges posed by drug-related issues, particularly in the detection, management, and prevention of synthetic drugs. The enhancement of data sharing, technological exchange, and collaborative actions among nations plays an instrumental role in the establishment of a more efficient and coordinated global drug governance system, better equipping the international community to address the threats posed by drugs to public health and social security.
    Keywords:  CiteSpace; bibliometrics; illicit drugs; visual analysis; web of science
    DOI:  https://doi.org/10.3389/fmed.2025.1583173
  54. J Multidiscip Healthc. 2025 ;18 3357-3372
    Global Research Trends in Oxidative Stress and Myocardial Fibrosis: A Dual-Software Bibliometric Study.
    Sihan Jia, Yanjie Lian, Xiaolei Lai, Sinai Li, Juju Shang, Hongxu Liu.
       Objective: To conduct a visualization analysis of the literature on the role of oxidative stress in myocardial fibrosis (MF), explore the research progress, frontier hotspots, and development trends in this field, with the aim of providing a reference for the research on the prevention and treatment of MF related to oxidative stress.
    Methods: Web of Science was selected as the data source, and the relevant English literature on the role of oxidative stress in MF from the database establishment to December 31, 2024 was collected. Bibliometric methods were used for statistical analysis of the literature that met the research standards, and CiteSpace 6.3.R2 and VOSviewer 1.6.20 software were used for visualization of information such as publishing countries, institutions, authors, and keywords.
    Results: A total of 1831 SCI articles were included. The global publication volume showed an upward trend year by year, Publications increased by 16% annually after 2014, with China and the United States leading in publication volume. Keyword and cited literature analysis showed that the research hotspots and frontiers in this field mainly include the phenomenon of extracellular matrix (ECM) cell migration, the activation of the renin-angiotensin-aldosterone system, the regulatory mechanisms of oxidative stress in MF of different etiologies, and the mechanisms of action of oxidative stress in MF.
    Conclusion: The field of research into the role of oxidative stress in myocardial fibrosis is currently experiencing a period of rapid expansion. By leveraging the complementary strengths of CiteSpace for analyzing temporal and geographic trends, and VOSviewer for mapping collaboration networks, researchers have gained multidimensional insights into this area. The identification of the NLRP3 inflammasome as the fastest-growing research frontier, highlights its potential as a novel therapeutic target for clinical investigation. The mechanism by which oxidative stress activates the NLRP3 inflammasome signaling pathway to promote myocardial fibrosis is likely to emerge as a significant future research trend and warrants further in-depth exploration and study.
    Keywords:  bibliometrics; citespace; myocardial fibrosis; oxidative stress; visual analysis
    DOI:  https://doi.org/10.2147/JMDH.S525389
  55. Int J Gynaecol Obstet. 2025 Jun 18.
    From conference to journal: Analyzing the path to publication for EUGA and JOGS 2022 abstracts.
    Reut Rotem, Bobby D O'Leary, Claire M McCarthy, Barry A O'Reilly, Orfhlaith E O'Sullivan.
       OBJECTIVE: To determine the full-text publication rate of abstracts presented at the European Urogynaecological Association (EUGA) and the Junior Obstetrics and Gynecology Society (JOGS) annual scientific meetings in 2022, and to compare variables such as publication format, number of authors, and journal impact factor.
    METHODS: Abstract lists from the 2022 EUGA and JOGS meetings were reviewed. PubMed searches were conducted to identify corresponding full-text publications up to August 2024 inclusive. Matches were determined based on substantial similarities in study title, authorship, and study design. Statistical comparisons were made using χ tests and Mann-Whitney U tests.
    RESULTS: A total of 304 abstracts were included (138 EUGA, 166 JOGS), with an overall publication rate of 21.1%. EUGA had a significantly higher publication rate than JOGS (31.9% vs. 12.7%, P < 0.001). Oral presentations were more likely to be published than poster presentations (P < 0.001), with no significant difference in oral presentation publication rates between conferences (50% vs. 40%, P = 0.636). Poster presentations at EUGA had a higher publication rate than JOGS (22.3% vs. 8.9%, P = 0.006). Abstracts were more likely to be published if they had a greater number of authors (P < 0.001). The median journal Impact factor was 2.6, and 50% of published articles were open access.
    CONCLUSION: International and national conferences play a crucial role in disseminating evidence, although just over one-fifth of presented abstracts progress to publication. A higher number of authors was associated with increased publication rates. Notably, oral presentations at both national and international levels were linked to favorable publication outcomes.
    Keywords:  education; medical literature; training; urogynecology
    DOI:  https://doi.org/10.1002/ijgo.70319
  56. J Alzheimers Dis. 2025 Jun 17. 13872877251351042
    Bibliometric analysis of the interplay between Alzheimer's disease and type 2 diabetes mellitus: Trends, hotspots, and emerging research areas.
    Ming Cheng, Ya-Dong Wei, Xin Zheng, Xin-Ran Gao, Huai-Zhi Sun, Jin-Fang Ge.
      BackgroundType 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD) are major global health concerns, characterized by rising prevalence, high healthcare costs, and significant reductions in patients' quality of life. Emerging evidence suggests that individuals with T2DM have nearly double the risk of developing AD, potentially due to overlapping mechanisms such as insulin resistance, oxidative stress, and neuroinflammation.ObjectiveThis study aims to systematically explore the evolving research landscape at the intersection of T2DM and AD over the past two decades, identifying major contributors, shifting research focuses, and emerging trends to inform future investigations and therapeutic development.MethodsA comprehensive bibliometric analysis was conducted using data retrieved from the Web of Science Core Collection (WoSCC) spanning 2000 to 2024. A total of 3087 publications were analyzed using CiteSpace and the R package bibliometrix to assess publication trends, collaborative networks, and thematic evolution.ResultsThe number of publications has steadily increased, with the United States and China emerging as dominant contributors. Institutions such as the University of California and Harvard University led in productivity and influence. Early research emphasized broad risk factors and cardiovascular comorbidities, while recent studies have shifted toward molecular mechanisms, particularly insulin resistance, neurodegeneration, and oxidative stress.ConclusionsThis 24-year bibliometric overview reveals a dynamic and expanding research field linking T2DM and AD. The findings highlight key geographic and institutional contributors, evolving thematic foci, and knowledge gaps, offering a valuable foundation for future research and potential therapeutic innovations.
    Keywords:  Alzheimer's disease; CiteSpace; bibliometrics; type 2 diabetes mellitus
    DOI:  https://doi.org/10.1177/13872877251351042
  57. J Gastrointest Cancer. 2025 Jun 19. 56(1): 139
    Comprehensive Bibliometric Analysis of Prediction Models for HCC: Current Trends and Future Prospects.
    Dong Li, Jingchao Sun, Xifeng Fu, Fei Gao.
       BACKGROUND: Hepatocellular carcinoma (HCC) is the most common primary malignant liver tumor, with rising incidence and mortality rates posing a significant threat to global public health. Accurate prediction of liver cancer occurrence and progression is essential for improving patient prognosis. This study uses bibliometric methods to analyze the current state and future trends in liver cancer prediction research.
    METHODS: A search was conducted in the Web of Science (WOS) database on October 22, 2023, identifying 1092 articles on liver cancer prediction. These articles were quantitatively analyzed using CiteSpace 6.2 software, with a focus on research hotspots, authors, countries, and keywords.
    RESULTS: The study involved 114 countries, 4254 institutions, and 280 journals, with 48,788 citations. China (826 papers) and the USA (96 papers) dominate the field. Leading institutions include Sun Yat-sen University, Fudan University, Zhejiang University, and Yonsei University. The most cited journals were Hepatology (2209 citations) and Journal of Hepatology (946 citations). Frontiers in Oncology had the highest H-index (14). Key authors include Kim Seung Up (23 papers) and Ahn Sang Hoon (H-index = 14). Early research focused on risk factors and staging, while recent studies emphasize DNA methylation, immune microenvironments, and tumor metastasis. Future research will focus on multi-omics data integration and AI-driven predictive model optimization.
    CONCLUSION: This study provides a comprehensive overview of liver cancer prediction research, highlighting key trends and the potential of multi-omics data and machine learning to enhance predictive models and clinical outcomes.
    Keywords:  Bibliometric; Liver cancer; Model scoring system; Prognosis prediction
    DOI:  https://doi.org/10.1007/s12029-025-01249-1
  58. Environ Geochem Health. 2025 Jun 17. 47(7): 272
    A scientometric analysis of biochar applications for soil remediation in mining-affected environments: research trends, intellectual structure, and emerging themes.
    Dengkui Zhang, Erastus Mak-Mensah.
      This study conducts a scientometric analysis to explore research trends, intellectual structures, and emerging themes in biochar applications for soil remediation in mining-affected environments from 2014 to 2024. Using bibliometric data retrieved from Scopus and Web of Science Core Collection, a dataset of 6093 unique peer-reviewed articles was analyzed. Descriptive bibliometric indicators, co-authorship and co-citation networks, and keyword co-occurrence patterns were visualized using the Bibliometrix R package and CiteSpace. The findings reveal significant growth in biochar research post-2018, driven by its increasing application in stabilizing heavy metals and improving soil quality. Co-citation cluster analysis identifies key thematic areas, including "mine soil," "cadmium-contaminated soil," and "dynamic redox conditions," reflecting biochar's role in addressing complex contamination challenges. High citation and sigma values emphasize seminal contributions, particularly on biochar's physicochemical properties and its interactions with heavy metals and microbial communities. Emerging trends highlight growing interest in ecological restoration, microbial dynamics, and innovative approaches such as nanobiochar and machine learning applications. This study provides critical insights into the evolution and interdisciplinary scope of biochar research, offering a roadmap for advancing its application in soil remediation and sustainable land management. Future directions include optimizing biochar formulations for diverse contaminants, integrating computational tools, and exploring its long-term ecological impacts to enhance its transformative potential for environmental sustainability.
    Keywords:  Biochar; Heavy metal stabilization; Mining-affected environments; Scientometric analysis; Soil remediation; Sustainable land management
    DOI:  https://doi.org/10.1007/s10653-025-02583-w
  59. Appl Neuropsychol Child. 2025 Jun 14. 1-17
    Executive functions in children with ADHD: A comprehensive bibliometric analysis.
    Kızbes Meral Kılıç, Emine Ahmetoğlu.
      Executive functions, which are closely associated with the functioning of the frontal lobes, encompass a set of cognitive processes that enable individuals to better adapt to their environment. It is known that individuals with Attention Deficit Hyperactivity Disorder (ADHD) have deficiencies in executive functions. To the best of our knowledge, no study has used bibliometric analysis to investigate the issue of executive functions in children with ADHD. This study employed the bibliometric analysis software VOS viewer and the statistical computing platform RStudio to examine 905 studies. This study reveals a notable increase in international research on executive functions in children with ADHD over the years. The highest number of publications on executive functions in children with ADHD are the Journal of Attention Disorders, Child Neuropsychology, and Archives of Clinical Neuropsychology. In the early years of this research field, there was a greater emphasis on brain imaging studies, including evoked potentials, transcranial magnetic stimulation, and evoked-related potentials. As time progressed, greater emphasis was placed on variables within the living environment. This research provides a comprehensive examination of global studies on executive functions in children diagnosed with ADHD, considering a multitude of variables. The findings presented here will inform forthcoming studies in this area, which will contribute to the accumulation of knowledge in this field.
    Keywords:  ADHD; bibliometric analysis; children; executive functions
    DOI:  https://doi.org/10.1080/21622965.2025.2518293
  60. Brain Circ. 2025 Apr-Jun;11(2):11(2): 113-126
    The role of antioxidant therapy in modulating neuropathic pain: A systematic review of mechanistic insights and research trends (2003-2024).
    Zikai Xu, Zhen Li, Ying Dong, Yao Chen, Ming Li, Baoying Song, Yang Zhang, Miaowen Jiang, Xuxiang Zhang.
      This bibliometric analysis investigates the role of antioxidant therapy in addressing neuropathic pain, emphasizing mechanistic insights and research trends from 2003 to 2024. Neuropathic pain, often unresponsive to standard treatments, is closely associated with oxidative stress as a key factor in its pathophysiology. This study utilizes the Web of Science Core Collection to analyze 699 articles related to "antioxidants" and "neuropathic pain." CiteSpace software was employed to examine publication trends, global collaborations, co-citation networks, and research hotspots. Results indicate a consistent rise in research activity, peaking in 2022, with China, India, and Italy as leading contributors. The University of Florence and Universidade Federal de Santa Maria emerged as prominent institutions, while influential authors included Pol Olga and Trevisan Gabriela. Key studies highlighted oxidative stress and neuropathic pain mechanisms, with neuroinflammation and specific molecular pathways gaining attention as emerging research foci. The findings underscore the growing interest in antioxidant therapies as potential interventions for neuropathic pain. Despite significant advances in understanding underlying mechanisms, there is a need for further exploration of novel antioxidants and their clinical applications. Enhanced international collaboration and the use of advanced molecular techniques are essential to drive future progress in this field.
    Keywords:  Antioxidant; bibliometric analysis; brain injury; neuropathic pain
    DOI:  https://doi.org/10.4103/bc.bc_72_24
  61. Surgery. 2025 Jun 16. pii: S0039-6060(25)00330-7. [Epub ahead of print]184 109478
    State family support policies and their impact on women's representation and productivity in surgical research: A web-scraping comparative analysis.
    Georgios Karamitros, Heather J Furnas, Michael P Grant, Sofoklis Goulas.
       BACKGROUND: Gender disparities in academic surgery persist, with women underrepresented as first authors and facing significant barriers to research productivity. Family-supportive policies, including paid family leave and reproductive rights protections, have been suggested as potential solutions to mitigate these disparities. However, their impact on women representation in surgical research has not been comprehensively evaluated.
    STUDY DESIGN: This cross-sectional analysis, using a web-scraping methodology, examined 198,542 first-author publications from 388 PubMed-indexed surgery journals published between 2010 and 2022. Gender differences in research output and representation were assessed across US states with and without family-supportive policies, specifically mandatory paid family leave and protective reproductive rights. We compared women representation among first authors and analyzed the average publication count for women authors, examining gender disparities at publication thresholds of 1, 2, and 5 papers.
    RESULTS: Women comprised 33.0% of all first authors, with representation decreasing at higher publication thresholds. States with paid family leave showed higher women representation among first authors compared with non-paid family leave states (34.2% vs 32.3%; P < .001), and similarly, protective reproductive rights states had more women representation than restrictive states (33.9% vs 32.0%; P < .001). Among authors with 5 or more publications, women represented 25.1% in paid family leave states versus 22.6% in non-paid family leave states (P = .005), and 24.6% in reproductive rights states versus 22.3% in restrictive states (P = .010). Women in states with these policies also saw significantly higher average publication counts (P < .001).
    CONCLUSION: State-level paid family leave and reproductive rights policies are associated with improved women representation and reduced gender disparities in surgical research. Our results indicate a statistically significant association between family-supportive policies and increased women's authorship, suggesting that such policies may play a role in shaping the academic trajectories of women in surgery.
    DOI:  https://doi.org/10.1016/j.surg.2025.109478
  62. Arch Sex Behav. 2025 Jun 19.
    Two Decades of Gender Differences in Pornography Research Topics.
    Jingyuan Yu, Aliya Andrich, Max Schindler.
      This exploratory study investigates the potential gender differences in research priorities, driven by factors such as established sexual stigma and traditional gender norms surrounding pornography. Using temporal and thematic analyses, we identify and examine research topics of 6,145 pornography studies published between 2001 and 2024. Our findings suggest that the lead author's gender may influence topic selection, with women exploring topics that have historically been underrepresented or overlooked. Furthermore, female-led publications have engaged with internet and web-related research earlier and more prominently. Additionally, our analyses outline the evolution of male- and female-led publication patterns in the field, highlighting a trend toward more balanced representation. This study aims to serve as a foundational basis for future research, encouraging more thorough investigations into gender disparities and their underlying causes within this domain. We also highlight the importance of longitudinal research to uncover potential gender disparities over time.
    Keywords:  Bibliometrics; Gender differences; Longitudinal analysis; Pornography; Thematic mapping
    DOI:  https://doi.org/10.1007/s10508-025-03175-6
  63. J Med Internet Res. 2025 Jun 16. 27 e60071
    Multidisciplinary Contributions and Research Trends in eHealth Scholarship (2000-2024): Bibliometric Analysis.
    Lana V Ivanitskaya, Dimitrios Zikos, Elina Erzikova.
       BACKGROUND: Fueled by innovations in technology and health interventions to promote, restore, and maintain health and safeguard well-being, the field of eHealth has yielded significant scholarly output over the past 25 years.
    OBJECTIVE: This study aims to offer a big picture of research developments and multidisciplinary contributions to eHealth that shaped this field up to 2024. To that end, we analyze evidence from 3 corpora: 10,022 OpenAlex documents with eHealth in the title, the 5000 most relevant eHealth articles according to the Web of Science (WoS) algorithm, and all available (n=1885) WoS eHealth reviews.
    METHODS: Using VOSviewer, we built co-occurrence networks for WoS keywords and OpenAlex concepts. We examined clusters, categorized terminology, and added custom overlays about eHealth technologies, stakeholders, and objectives. A cocitation map of sources referenced in WoS reviews helped identify scientific fields supporting eHealth. After synthesizing eHealth terminology, we proceeded to build a conceptual model of eHealth scholarship grounded in bibliometric evidence.
    RESULTS: Several research directions emerged from bibliometric networks: eHealth studies on self-management and interventions, especially in mental health; telemedicine, telehealth, and technology acceptance; privacy, security, and design concerns; health information consumers' literacy; health promotion and prevention; mHealth and digital health; and HIV prevention. Conducted at the individual, health system, community, and society levels, eHealth studies focused on health and wellness across the human lifespan. Keywords such as internet (mean publication year 2017), telemedicine (2018), telehealth (2018), mHealth (2019), mobile health (2020), and digital health (2021) were strongly linked to literature indexed with eHealth (2019). Different types of eHealth apps were supported by research on infrastructures: networks, data exchange, computing technologies, information systems, and platforms. Researchers' concerns for eHealth data security and privacy, including advanced access control and encryption methods, featured prominently in the maps, along with terminology related to health analytics. Review authors cited a wide range of medical sources and journals specific to eHealth technologies, as well as journals in psychology, psychiatry, public health, policy, education, health communication, and other fields. The Journal of Medical Internet Research stood out as the most cited source. The concept map showed a prominent role of political science and law, economics, nursing, business, and knowledge management. Our empirically derived conceptual model of eHealth scholarship incorporated commonly researched stakeholder groups, eHealth application types, supporting infrastructure, health analytics concepts, and outcomes.
    CONCLUSIONS: Drawing upon contributions from many disciplines, the field of eHealth has evolved from early studies of internet-enabled communications, telemedicine, and telehealth to research on mobile health and emerging digital health technologies serving diverse stakeholders. Digital health has become a popular alternative term to eHealth. We offered practical implications and recommendations on future research directions, as well as guidance on study design and publication.
    Keywords:  AI; VOSviewer; app; application; artificial intelligence; bibliometric analysis; conceptual model; digital; digital health; digital intervention; digital technology; eHealth; electronic health; mHealth; mobile application; mobile health; remote consultation; smartphone; telehealth; telemedicine; virtual care; virtual health; virtual medicine
    DOI:  https://doi.org/10.2196/60071
  64. Can J Surg. 2025 May-Jun;68(3):68(3): E253-E264
    Gender representation in professorship and research productivity across all surgical specialties in Canadian academic institutions.
    Stuti M Tanya, Anne Xuan-Lan Nguyen, Maxine Joly-Chevrier, Daiana Roxana Pur, Sanjay Sharma, Fiona Costello, Femida Kherani, Vincent Quoc-Huy Trinh, Isabelle Hardy, Leonardo Lando.
       BACKGROUND: Disparate gender representation among Canadian academic surgeons is documented; however, the association of academic rank with research productivity across all surgical specialties is not well understood. Our objective was to assess differences in gender representation by academic rank and research productivity metrics for surgical specialties in Canadian academic centres.
    METHODS: This retrospective, cross-sectional, comparative study used online public databases in 2021. Data sources included the Canadian Resident Matching Service program descriptions, College of Physicians and Surgeons databases, the Scopus platform, and professional websites. Gender distribution by academic rank, research productivity metrics, institution, and surgical specialty were tested for a 0.5 proportion rate. We used a generalized logistic regression model adjusting for confounders to assess gender association with ordinally ranked academic rank. We defined significance by p < 0.05 with reported 95% confidence intervals.
    RESULTS: We assessed 10 surgical specialties across 17 Canadian academic institutions. Women surgeons were underrepresented in 16 out of 17 centres (p < 0.001), comprising the majority in only obstetrics-gynecology (p < 0.001). Women were also less represented as assistant (37%), associate (27%), and full professors (18%) (p < 0.001), with lower mean h-index (6.4, p < 0.001), years active in research (11.5, p < 0.001), number of publications (18, p < 0.001), and m-quotient (0.42, p < 0.001). Multivariate analysis showed that men were more likely to be represented in senior professorship regardless of research productivity, institution, and specialty determinants (odds ratio 1.30-1.33, p = 0.001-0.024).
    CONCLUSION: Women surgeons were underrepresented across all academic ranks, were less likely to achieve senior professorship, and had lower research productivity metrics.
    DOI:  https://doi.org/10.1503/cjs.015723
  65. Front Oncol. 2025 ;15 1583364
    Two decades of progress in gastric cancer peritoneal metastasis: a bibliometric perspective on molecular mechanisms and therapeutic innovations.
    Jin Qian, Xiaoxuan Tu, Jianglin Chen, Sisi Chen, Yi Zhou, Chuan Sun, Zhibing Wu.
       Background: Gastric cancer (GC) is the fifth most common malignant tumor worldwide. The peritoneum is a common site of metastasis in advanced GC, and patients with gastric cancer peritoneal metastasis (GCPM) have a very low 5-year survival rate. Systemic therapy has limited efficacy for peritoneal metastases, and early diagnosis is difficult. In this paper, we analyzed the GCPM-related literature by bibliometric methods, aiming to identify the research hotspots and trends and to provide a basis for clinical practice and research planning.
    Methods: Based on the Web of Science Core Collection database (WoSCC), we screened the GCPM-related literature published from 2004 to 2024. Countries, institutions, authors, journals, and keywords were analyzed and visualized by tools such as CiteSpace, VOSviewer, Scimago Graphica, RStudio, and the Bibliometrix package.
    Result: A total of 2416 publications were included in this study. The growth rate of GCPM publications is positive until 2021, with a slowdown in the near future. Japan dominated the research output (842 publications), followed by China (748 publications) and the United States (268 publications). Japanese-affiliated organizations and researchers are extremely productive in the field of GCPM. The most frequently cited document was Japanese gastric cancer treatment guidelines 2014 (ver. 4) (citations = 2076). Research focuses on four major clusters: (1) molecular mechanisms of GCPM; (2) prognosis of GCPM; (3) chemotherapy of GCPM; and (4) intraperitoneal treatment of GCPM. Emerging trends include key pathways of GCPM, artificial intelligence (AI) and multi-omics-driven early diagnosis, novel intraperitoneal therapeutic modalities, and immunologic/targeted drugs.
    Conclusion: Japan is a leader in GCPM research. Recently, the focus of GCPM research has shifted from basic treatment to precision and personalized treatment through the integration of molecular mechanisms, novel intraperitoneal therapeutic modalities, and AI technologies. Current challenges include the lack of standardized validation systems for emerging technologies and regional differences in clinical practice. In the future, there is a need to promote global collaborative trials and optimization of multimodality therapy. The results of this study provide a key direction and systematic basis for future exploration of GCPM.
    Keywords:  bibliometric; gastric cancer; intraperitoneal treatment; molecular mechanisms; peritoneal metastasis
    DOI:  https://doi.org/10.3389/fonc.2025.1583364
  66. Can J Ophthalmol. 2025 Jun 19. pii: S0008-4182(25)00267-4. [Epub ahead of print]
    Impact of 11 years of glaucoma research funding: Glaucoma Research Society of Canada (2010-2020).
    William J Herspiegel, Melina Moeinkhah, Anastasiya Vinokurtseva, Graham Trope, Cindy M L Hutnik.
       OBJECTIVE: The Glaucoma Research Society of Canada (GRSC) is Canada's only nonprofit organization dedicated to funding peer-reviewed glaucoma research. This study evaluates the impact of GRSC-funded projects using established research productivity metrics.
    DESIGN: Retrospective study.
    METHODS: GRSC-funded grants from 2010 to 2020 were analyzed, including project details and funding amounts. Research productivity was assessed by (1) the number of peer-reviewed publications and (2) the number of conference presentations at major North American meetings. Publications were identified via PubMed searches of grant recipients, ensuring alignment with GRSC-funded topics. Conference presentations were determined by reviewing accepted abstracts from 5 key ophthalmology meetings: the Canadian Ophthalmological Society, American Society of Cataract and Refractive Surgery, American Academy of Ophthalmology, American Glaucoma Society, and Association for Research in Vision and Ophthalmology. Research output was analyzed in relation to funding costs.
    RESULTS: Of 135 grants totaling $2,220,822, 84 (62%) led to at least one publication (92 total), while 67 (50%) resulted in conference presentations (85 total). The average research output per grant was 1.3, with costs of $12,547 per research output and $24,139 per publication. Research costs increased over time, with a slight decrease in 2019.
    CONCLUSIONS: GRSC-funded research consistently generates peer-reviewed knowledge, with over half of projects producing publications or presentations. Despite rising research costs, the high success rate in knowledge dissemination underscores GRSC's critical role in sustaining and advancing glaucoma research in Canada.
    DOI:  https://doi.org/10.1016/j.jcjo.2025.05.022
  67. F1000Res. 2024 ;13 1051
    What we know and what should we know about the future of blockchain in finance.
    Shikta Singh, Rachana Jaiswal, Shashank Gupta, Chinmoy Kumar.
       Background: In response to the transformative impact of blockchain technology on economic and financial landscapes, there is a critical need for a review study that analyses the knowledge landscape from diverse perspectives.
    Methods: This research VOSviewer, and Bibliometrix to undertake a bibliometric analysis of the expanding literature related to blockchain technology within the financial sector. Through a examination of 500 published articles, the study identifies insightful trends, patterns, and emerging domains on a global scale.
    Results: The findings highlight the advancing trajectory of blockchain research in finance, with a notable concentration of studies originating from the United States and China, both in terms of total publications and citations. Key thematic clusters identified include "smart contracts," "financial institutions," "initial coin offerings," and "big data analytics." Intersections with financial risk management, digital transformation, and the integration of big data analytics with artificial intelligence and machine learning are particularly noteworthy, marking focal points of exploration.
    Conclusions: While affirming the potential of blockchain, the analysis also sheds light on persistent impediments hindering its widespread adoption and utilization. This study not only contributes to the current understanding of blockchain in finance but also serves as a valuable resource for future researchers. It guides systematic reviews by pinpointing prominent journals and influential authors within the dynamic field of blockchain finance, thereby fostering a deeper understanding and facilitating further exploration in this evolving field.
    Keywords:  Blockchain; finance; VOS viewer; networking analysis; literature review.
    DOI:  https://doi.org/10.12688/f1000research.153215.1
  68. Transplant Direct. 2025 Jul;11(7): e1819
    Bridging the Gap: The State of Global Transplant Research Collaboration.
    Isabella Faria, Stalin Canizares, Adriana Montalvan, Paulo N Martins, Griffin M Weber, Marwan Kazimi, Devin E Eckhoff.
       Background: The field of transplant research has long been recognized for its innovative approaches and international collaborations. This study aims to dissect the landscape of global collaborations within transplant research during a past decade.
    Methods: Through a comprehensive bibliometric and network analysis of 5 high-impact factor transplantation journals from 2012 to 2021, we evaluated scientific production and collaboration patterns in 9 250 articles. International, national, and single-institution collaboration types were analyzed, using coauthorship as a measure of scientific collaboration.
    Results: The data set revealed 40 622 authors from 2 094 institutions across 94 countries, with a marked increase in international collaborations during the past decade. The United States and Western European countries emerged as central nodes in the global network, facilitating the majority of collaborative efforts. Only 2.2% of potential institutional collaborations were explored during the decade. We found a lower chance of citations for single-institution research over time. Low- and middle-income countries were underrepresented in high-impact transplant research.
    Conclusions: The findings underscore the necessity of fostering inclusive, equitable research collaborations that bridge the gap between high-income countries and low- and middle-income countries, limiting their contributions to advancing global patient care. Practical recommendations for enhancing global collaboration in transplant research include facilitating academic exchanges, equitable collaboration practices, and increased funding opportunities. This study calls for a strategic shift toward a more inclusive and integrated global research landscape, aiming to advance transplant research and patient care universally. Addressing these disparities could lead to a more integrated global research landscape, benefiting transplant research and patient care universally.
    DOI:  https://doi.org/10.1097/TXD.0000000000001819
  69. Discov Oncol. 2025 Jun 21. 16(1): 1171
    Global research trends on Chinese patent drugs inducing programmed cell death in cancer: a bibliometric analysis (1998-2024).
    Min Song, Chunyan Teng, Xiaodong Zheng, Shizhen Tan, Yipeng Guo.
       BACKGROUND: Chinese patent drugs, standardized formulations rooted in traditional Chinese medicine, have gained attention for their potential to induce programmed cell death (PCD) in cancer cells. Emerging evidence suggests that these formulations may affect multiple PCD pathways, including apoptosis, autophagy, ferroptosis, pyroptosis, and necroptosis, thus offering a multifaceted approach to tumor suppression.
    OBJECTIVES: This study aimed to map the global research landscape on Chinese patent drugs in cancer-related PCD, examining publication trends, principal contributors, and thematic evolutions. The analysis also sought to provide insights that could guide future investigations and clinical applications.
    METHODS: Bibliometric data were extracted from the Web of Science Core Collection (1998-2023), focusing on articles investigating Chinese patent drugs and PCD in oncological contexts. R-bibliometrix was used for descriptive statistics and trend analyses, while VOSviewer generated network visualizations of co-occurring keywords, collaboration patterns, and co-citation clusters.
    RESULTS: Overall publication output increased markedly, with China leading in both volume and impact. Collaboration networks revealed extensive international partnerships, underscoring global interest in standardized herbal formulations. Keyword mapping highlighted a shift from early apoptosis-centric studies to more diverse regulated cell-death pathways, indicating greater mechanistic depth and exploration of synergistic effects with conventional therapies.
    CONCLUSION: Chinese patent drugs are increasingly recognized as promising agents for modulating PCD in cancer cells. Ongoing work focuses on standardized manufacturing, robust clinical validation, and mechanistic elucidation. These trends position Chinese patent drugs at a pivotal juncture for advancing integrative oncology and enhancing patient outcomes.
    Keywords:  Apoptosis; Cancer; Chinese patent drug; Integrative oncology; Multi-target therapy; Programmed cell death
    DOI:  https://doi.org/10.1007/s12672-025-02913-5
  70. Am J Mens Health. 2025 May-Jun;19(3):19(3): 15579883251346819
    From Androgen Deprivation to Precision Therapy: A Bibliometric Review of Global Research Trends (2008-2023).
    Longjun Huang, Wenjuan He, Yong Guo.
      This review employs bibliometric methods to map the evolving landscape of prostate cancer endocrine therapy research over the past 15 years. Through analysis of 961 articles from the Web of Science Core Collection, we identified key trends in therapeutic innovation and clinical translation. The United States emerged as the dominant contributor (34.96% of publications), with Harvard University and the University of California System leading institutional output. Three paradigm shifts emerged: early stage research focused on optimizing androgen deprivation therapy (ADT) efficacy (2008-2013), followed by castration-resistant prostate cancer (CRPC) drug development (2014-2016), and recent emphasis on combination therapies and molecular targeting (2017-2023). The top 50 most cited papers confirmed that keyword clusters directly corresponded to pivotal trials, including TAMPEDE (NCT00268476) and PROSPER (NCT02003924). The translational science spectrum model revealed that 68% of current clinical applications originated from basic research on androgen receptor variants. Emerging frontiers include prostate-specific membrane antigen-targeted radioligand therapy and immunotherapy-ADT synergies. This synthesis provides clinicians with an evidence-based roadmap to navigate therapeutic advancements while highlighting the critical need for international collaboration in addressing persistent challenges such as treatment resistance.
    Keywords:  bibliometrics; endocrine therapy; prostate cancer; visual analysis
    DOI:  https://doi.org/10.1177/15579883251346819
  71. Heliyon. 2025 Apr;11(9): e43264
    Retraction notice to "The bibliometric analysis of previous twenty-five years' literature: A microfinance review" [Heliyon 10 (2024) e24979].
    Kashif Beg, B Padmapriya, Syed Noorul Shajar, Md Moneef Ahmad, Abdul Ghani Faiyyaz.
      [This retracts the article DOI: 10.1016/j.heliyon.2024.e24979.].
    DOI:  https://doi.org/10.1016/j.heliyon.2025.e43264
  72. Hepatol Res. 2025 Jun 17.
    Utilizing Altmetrics to Track Advancements in Noninvasive Tests for MASLD.
    Masato Yoneda, Yoshio Sumida, Yoshihiro Kamada, Hirokazu Takahashi, Hideki Fujii, Shinichi Takeda, Azadeh Hosseini-Tabatabaei, Atsushi Nakajima.
       OBJECTIVE: Noninvasive tests (NITs) are vital for the early diagnosis of the stage of metabolic dysfunction-associated steatotic liver disease (MASLD). This study investigates relationships between altmetric scores, traditional Web of Science metrics (citations and impact factor), and the clinical impact as assessed by multiple experts.
    METHODS: Articles evaluating NITs for MASLD/MASH published in 2022 were evaluated without language/article-type restrictions by five expert hepatologists based on three subtopics: immediate usefulness in daily clinical practice (practicality), potential influence on future guidelines (impact), and new viewpoints and/or topics (innovation). Eligible articles were ranked 1-10 by physicians and scored by rank (10 points to rank 1, 9 points to rank 2, and so on), which were summed across all physicians by subtopic. The physicians' total score was derived from the sum of the subtopic scores. Altmetric scores were manually retrieved using Altmetric Explorer and compared with the summed physician scores and traditional metrics (Clarivate) using Pearson's correlation analysis.
    RESULTS: Moderate positive correlations existed between the altmetric attention score (AAS) and physician total score (r = 0.52), and between the AAS and innovation subtopic (r = 0.56). Weaker positive correlations existed between the AAS and practicality (r = 0.20) and impact (r = 0.14) subtopics. Among the high-ranking articles, the innovation subtopic demonstrated greater concordance across the five experts than the practicality and impact subtopics.
    CONCLUSION: The use of altmetrics alongside traditional metrics may contribute to physicians involved in MASLD care obtaining innovative research information on NIT more quickly.
    Keywords:  altmetric attention score; biomarker; fibrosis; nonalcoholic fatty liver disease/diagnosis; scientific impact; social media; traditional bibliometric metric
    DOI:  https://doi.org/10.1111/hepr.14229
  73. Interact J Med Res. 2025 Jun 17. 14 e70554
    Impact Factor Trends of Top Obstetrics and Gynecology Journals During COVID-19.
    Minhazur Sarker, Emily Yang, Ukachi Emeruwa, Timothy Wen.
       Unlabelled: Obstetrics and gynecology journal impact factor trends during the COVID-19 pandemic were similar to those seen among other medical specialties, and our findings further highlight the ongoing need to implement a metric of research impact that is not as easily manipulated by selective publication.
    Keywords:  COVID-19; impact factor; research impact
    DOI:  https://doi.org/10.2196/70554
  74. Health Sci Rep. 2025 Jun;8(6): e70926
    Suicidology Needs a More Inclusive Approach for Low and Middle-Income Countries.
    S M Yasir Arafat, David Lester.
       Background and Aims: Suicide is a global challenge. About three-quarters of suicides happen in low- and middle-income countries (LMICs). There are disparities in research and publication opportunities between countries based on income category. We aimed to discuss the disparities in research and publication on suicide between high-income countries and LMICs.
    Methods: We made a search in Scopus with the term "suicide" in early February 2025 and noted the number of publications and publishing journals.
    Results: Along with suicidology journals, mental health journals are publishing research on suicide. There are no open access journals indexed in PubMed, Scopus, and PsycINFO which have no concerns about limited space. The leading three journals with good indexing follow a subscription/hybrid model with limited space that has results in the exclusion of papers of authors from LMICs.
    Conclusions: Immediate attention is warranted to ensure that research on suicidal behavior from LMICs be solicited and published in journals currently available in the major indexing services. An open access journal focused on suicidal behavior without page limitations and with minimal or zero cost would be very useful.
    Keywords:  PubMed; high‐income country; journal; low‐ and middle‐income country; publication; suicide
    DOI:  https://doi.org/10.1002/hsr2.70926
  75. IBRO Neurosci Rep. 2025 Dec;19 1-16
    Mapping the knowledge of epilepsy and Potassium Channels: A scientometric analysis in CiteSpace and VOSviewer.
    Zheng Li.
      Epilepsy is one of the most common neurological diseases. Studies have suggested that epileptic seizures are directly related to ion channel abnormalities in the central nervous system. Activation of potassium ion channels may lead to increased cell excitability and abnormal neuronal excitation. Over the past decade, significant progress has been achieved in understanding the potassium ion channel abnormalities related to epilepsy. To facilitate further research, in this paper, we adopted the bibliometrics method (based on Web of Science database) and used CiteSpace and VOSviewer to visualize literature in the field (Potassium Channels-related epilepsy) from 2010 to 2023. A total of 2415 original research and summary papers were included, and the basic situation, subject theme, and knowledge structure evolution were analyzed and discussed step by step from macro to micro perspectives.
    Keywords:  CiteSpace; Epilepsy; Potassium Channels; Scientometric analysis
    DOI:  https://doi.org/10.1016/j.ibneur.2025.05.004
  76. Cell Adh Migr. 2025 Dec;19(1): 2520641
    The research trends and hotspots of claudins in the field of cancer.
    Weixin Jing, Linna Long, Xiaorui Zhang, Xia Li, He Huang.
      Claudins (CLDNs), as the key components of tight junctions, have been implicated as key factors in carcinogenesis and metastasis. A total of 1720 publications on CLDNs in the field of cancer were published from January 2005 to December 2022. The United States dominates the research on CLDNs in cancer, followed by China. China Medical University is the most productive, and Johns Hopkins University has the most citations. Morin PJ is credited with initiating research on CLDNs in cancer. CLDN18, the intestinal barrier, and the intestinal microbiota are the focus and hotspots in this field. The mechanism of CLDN-mediated metastasis still needs further investigation, and the development of CLDN-targeted therapies also needs to be explored in the future.
    Keywords:  CiteSpace; Claudin; Vosviewer; cancer; scientometric analysis
    DOI:  https://doi.org/10.1080/19336918.2025.2520641
  77. PLoS One. 2025 ;20(6): e0326216
    The adverse events of toripalimab in nasopharyngeal carcinoma based on FAERS database and bibliometric analysis.
    Qian Guo, Dong Dong, Zihan Dang, Shuman Huang, Xinjie Qiao, Baiquan Zhang, Yulin Zhao.
       BACKGROUND: Toripalimab, a monoclonal antibody designed to target PD-1, has recently received approval from the U.S. Food and Drug Administration (FDA) for use as a first-line treatment in adults diagnosed with metastatic or recurrent locally advanced nasopharyngeal carcinoma (NPC). The purpose of this study is to utilize the FAERS database and bibliometric analysis to examine adverse events associated with toripalimab in real-world settings, thereby enhancing the safety management of clinical medications.
    METHODS: This research implemented a disproportionality analysis to assess the safety of toripalimab by reviewing all adverse event reports from the FAERS database dating back to 2004, wherein toripalimab was recognized as the main suspected medication. Various statistical techniques were applied in the analysis, such as the reporting odds ratio (ROR), proportional reporting ratio (PRR), multi-item gamma Poisson shrinker (MGPS), and Bayesian confidence propagation neural network (BCPNN), to evaluate the adverse events linked to toripalimab. CiteSpace is utilized to search for authors, countries, keywords, and various indicators within research fields, facilitating the identification of research hotspots and future trends.
    RESULTS: From 2004 to 2024, 441 AEs linked to toripalimab were recorded across 27 SOCs. The top five SOCs were procedural complications, investigations, blood/lymphatic disorders, gastrointestinal disorders, and skin/subcutaneous disorders. At the PT level, the top five AEs by ROR were myelosuppression (n = 192, ROR 687.41), decreased granulocyte count (n = 11, ROR 515.72), immune-mediated hepatic disorder (n = 7, ROR 343.20), immune-mediated myocarditis (n = 3, ROR 214.68), and bicytopenia (n = 3, ROR 117.49). Additionally, 91.62% of AEs occurred within the first 30 days, and immune-related AEs were highlighted in bibliometric analysis.
    CONCLUSION: This research provides initial safety information regarding the real-world application of toripalimab, affirming previously acknowledged adverse effects and concurrently uncovering new possible risks. These results could act as important cautionary evidence for healthcare professionals and pharmacists engaged in administering toripalimab for NPC.
    DOI:  https://doi.org/10.1371/journal.pone.0326216
  78. Discov Nano. 2025 Jun 18. 20(1): 96
    2009-2023 Bibliometric analysis of the clinical value of graphene quantum dots in glioblastoma treatment.
    Jingyan Zhu, Xiaoqing Li, Zhenhua Lin, Linzhuo Qu, Hongjian Guan.
      Glioblastoma (GBM) is the most common primary brain tumour in adults and poses a serious health risk. Graphene quantum dots (GQDs) are zero-dimensional crystalline discs de-rived from two-dimensional graphene, which contribution of GQDs in the treatment of GBM and the great potential for future development. In this study, the Web of Science database was applied to search 462 relevant papers published between 2009 and 2023, and analyzed using VOS viewer and CiteSpace software tools. This analysis aims to provide researchers with insights into the current state of applications and to facilitate a clearer understanding of potential pathways and directions for future research in this field. Our study showed a continuous increase in the number of papers about GQDs in the treatment of GBM. In the field for more than a decade, GQDs has been a research priority in drug delivery due to their excellent optical and chemical properties. It is reasonable to believe that the use of GQDs for drug delivery for the treatment of GBM will be-come one of the extremely important research topics in the future.
    Keywords:  Clinical value; Drug delivery; Glioblastoma; Graphene quantum dots; Visualized analysis
    DOI:  https://doi.org/10.1186/s11671-025-04277-9
  79. HIV Med. 2025 Jun 20.
    Gender equality in leadership of HIV care cascade clinical trials: A methodological study.
    Fiona Rezene, Brendan Amoyaw, Myanca Rodrigues, Sandra Ofori, Lawrence Mbuagbaw.
       OBJECTIVES: Equitable representation in research leadership is essential across all areas of medical science. In the context of HIV-where women are disproportionately affected-examining gender distribution in the leadership of HIV trials is essential to assess progress towards equity and identify persisting barriers.
    METHODS: We conducted a methodological study of trials from the CASCADE database, which evaluates interventions to improve the HIV care cascade. We extracted first and last authors' names and used Genderize.io to determine their gender, classifying authors as 'women' if the probability was 60% or greater. The primary outcome was the proportion of trials with women in leadership (first or last author), with secondary outcomes examining the proportions of trials with women as: first authors, last authors and in both roles. We also assessed associations with country income level, focus on women participants, study setting, pragmatism and team size.
    RESULTS: Gender for both authorship roles could be determined in 332 trials, of which 233/332 (70.2%) had a woman first or last author; 169/334 (50.6%) had a woman first author; 143/337 (42.4%) had a woman last author and 74/332 (22.3%) featured women in both roles. Women's leadership increased over time but was not associated with country income level, gender focus, study setting or impact factor. Effectiveness trials and those with fewer authors were more likely to have women in leadership.
    CONCLUSIONS: Women's leadership in HIV trials has increased, reflecting progress in gender equity. However, smaller author teams appear to facilitate women's leadership, suggesting barriers in larger collaborations. Continued efforts are needed to ensure sustained progress and equitable representation.
    Keywords:  HIV care cascade; authorship; clinical trials; gender equality; women in leadership
    DOI:  https://doi.org/10.1111/hiv.70062
  80. Zhongguo Zhen Jiu. 2025 Jun 12. 45(6): 841-850
    [Visual analysis of the research status and trends in acupuncture and moxibustion treatment for respiratory diseases in the past decade].
    Wenxi Zhou, Peizhong Ren, Fengyan Lu.
       Objective: To analyze the research progress, hotspots, frontier trends and existing limitations of acupuncture and moxibustion treatment for respiratory diseases in the past decade using bibliometric and scientific knowledge mapping methods.
    Methods: Literature on acupuncture and moxibustion treatment for respiratory diseases published from January 1st, 2014 to June 30th, 2024, from CNKI, VIP, Wanfang, PubMed and Web of Science was retrieved. CiteSpace 6.1.R6 and VOSviewer V1.6.20 were used to perform visual analysis, including keyword co-occurrence and clustering, and to construct knowledge maps of acupuncture and moxibustion treatment for respiratory diseases.
    Results: A total of 1,106 Chinese articles and 185 English articles were included. High-frequency keywords focused on clinical diseases, treatment methods, efficacy observation, mechanisms etc. The main respiratory diseases treated with acupuncture and moxibustion included chronic obstructive pulmonary disease (COPD), asthma and cough. Commonly used acupoints included Feishu (BL13), Zusanli (ST36), Dazhui (GV14) and Shenshu (BL23), primarily involving the bladder meridian of foot-taiyang, conception vessel and lung meridian of hand-taiyin. Among the treatment methods dominated by acupuncture and moxibustion, the primary treatment method was electroacupuncture combined with moxibustion, and acupoint application was supplemented, with increasing emphasis on integrative Chinese and Western medicine and acupuncture combined with medication. The therapeutic mechanisms involved anti-inflammatory effects and inhibition of airway remodeling, with targets mainly associated with the NF-κB signaling pathway.
    Conclusion: Acupuncture and moxibustion demonstrates certain advantages in treating respiratory diseases such as COPD, asthma and cough, with mechanisms related to anti-inflammatory effects and inhibition of airway remodeling. Future research should focus on multi-center, large-sample, high-quality clinical and experimental studies to explore the optimal clinical treatment protocols and underlying mechanisms.
    Keywords:  acupuncture and moxibustion; bibliometrics; respiratory diseases; visual analysis
    DOI:  https://doi.org/10.13703/j.0255-2930.20241125-k0007
  81. Autoimmun Rev. 2025 Jun 16. pii: S1568-9972(25)00114-4. [Epub ahead of print]24(9): 103854
    Systematic evaluation of the associations between schizophrenia and autoimmune diseases: An umbrella review.
    Zhouyang Sun, Beibei Han, Qianlu Ding, Yuan Feng, Tingyi Jia, Yixin Ouyang, Xinru Guo, Jingyi Liang, Qianlong Huang, Changgui Kou, Wei Bai.
       OBJECTIVE: This study aims to assess research trends in the association between schizophrenia and autoimmune diseases, systematically review their relationship, and evaluate the credibility of existing evidence.
    METHODS: Bibliometric analysis was conducted using the bibliometrix package in R, along with VOSviewer and CiteSpace. Relevant systematic reviews and meta-analyses were retrieved from six databases: PubMed, Web of Science, Embase, CINAHL, PsycINFO, and the Cochrane Library. Summary risk estimates were recalculated using the DerSimonian and Laird method under a random-effects model, and the credibility of the evidence was assessed.
    RESULTS: The bibliometric analysis found that "meta-analysis" has become a frequently used keyword and may be a focal point for future research. The umbrella review included 17 articles, containing 24 report data points from 12 quantitative reviews. Results indicated that 9 reports assessed the relationship between schizophrenia and autoimmune diseases. Schizophrenia was significantly associated with autoimmune neurological disorders (RR = 1.42; 95 % CI = 1.18-1.72), providing suggestive evidence. Seven reports evaluated the impact of schizophrenia on autoimmune diseases, showing highly suggestive evidence that schizophrenia patients had a pooled relative risk of 2.22 (95 % CI = 1.95-2.52) for psoriasis. Eight reports assessed the impact of autoimmune diseases on schizophrenia, with bullous pemphigoid patients showing significantly higher schizophrenia prevalence (OR = 2.63; 95 % CI = 2.03-3.39).
    CONCLUSIONS: This study synthesizes evidence of varying levels, highlighting the association between schizophrenia and autoimmune diseases. It offers new insights for future exploration, fosters interdisciplinary collaboration, and provides valuable implications for public health policy development.
    Keywords:  Autoimmune diseases; Bibliometric analysis; Meta-analysis; Schizophrenia; Umbrella review
    DOI:  https://doi.org/10.1016/j.autrev.2025.103854
  82. J Med Internet Res. 2025 Jun 19. 27 e57980
    Managerial Challenges in Digital Health: Bibliometric and Network Analysis.
    Quentin Garçon, Benjamin Cabanes, Cédric Denis-Rémis.
       BACKGROUND: Digital health has emerged as a transformative force in modern health care systems; these systems have witnessed a surge in technological innovations and solutions over the past 2 to 3 decades. Some studies have provided overviews of keywords and journals that shed light on the current state of digital health research, and there is an increasing focus on this field of study, even in the literature on business, management, and managerial challenges. Papers and reviews are needed on challenges in digital health related to organization, management, and adoption of technological innovations, as there are currently no formal analyses or structured reviews.
    OBJECTIVE: Given the existing focus of the business and management literature on digital health, there is a need to unravel managerial challenges in digital health. By highlighting foundational themes and challenges in management science for digital health, our objective is to contribute nuanced insights into influential studies and the structure of knowledge in this interdisciplinary domain.
    METHODS: To delineate the evolving landscape of digital health management and highlight the main challenges, we conducted a comprehensive bibliometric analysis. Our analysis considered peer-reviewed, English-language papers or reviews in the management field that focused on digital health or closely related concepts. To better understand the dataset, we conducted a performance analysis. Then, we created a co-citation network using BibExcel and analyzed it by clustering the papers using the Louvain algorithm in Gephi.
    RESULTS: Of 1186 papers about digital health or closely related concepts published between 1994 and 2022, 520 (43.8%) were included in the co-citation network and 468 (39.5%) were placed in 4 significant clusters (>1% of the total number of nodes). The mere existence of the clusters shows that different managerial challenges have distinct research communities. The 4 clusters were (1) user adoption and engagement in mHealth, (2) adoption and trust in mHealth services, (3) digital transformation in health care, and (4) implementation challenges and ethical considerations. There are interdependent managerial challenges in digital health, and a dynamic literature review provides a more precise understanding of what is at stake (eg, adoption studies) and upcoming challenges (eg, ethical considerations).
    CONCLUSIONS: Our co-citation analysis unveiled evolving themes in the literature on digital health management. The exploration of clusters suggested dynamic shifts related to ethical considerations, health care organizations, and societal acceptance. We encourage further research on these topics and exploration of the intricate facets of the literature on digital health management. We hope that this study provides a more comprehensive understanding of the literature and will provide researchers insights into the principal challenges and unidentified gaps, such as the novel cluster on ethics, or the need for intercluster research to create links between research communities.
    Keywords:  adoption; bibliometrics; digital health; ecosystems; ethics; health challenges; literature review; mHealth; management; mobile health; privacy; telemedicine
    DOI:  https://doi.org/10.2196/57980
  83. Environ Pollut. 2025 Jun 11. pii: S0269-7491(25)01031-0. [Epub ahead of print]382 126658
    A critical review of microplastics and nanoplastics in wastewater: Insights into adsorbent-based remediation strategies.
    Khoi Lun Ho, Swee Pin Yeap, Kiat Moon Lee.
      This review aims to provide a comprehensive overview of the current state of research on the removal of microplastics (MPs) and nanoplastics (NPs), with a focus on adsorption-based solutions. The presence of plastic particles in the environment is a growing concern due to their widespread distribution across aquatic, terrestrial, and atmospheric systems. To address this environmental issue, researchers have explored various removal technologies, including coagulation, sand filtration, membrane filtration, and adsorption. A bibliometric analysis of 7641 keywords from 771 publications reveals that adsorption is the most widely studied removal technique. Thus, this has led to a deeper exploration of various adsorbents and their mechanisms, including their interactions with plastic particles and how they can be optimised for higher removal performance. The main adsorption mechanisms involve electrostatic interactions, hydrogen bonding, π-π interactions, and hydrophobic effects. Chemisorption is the primary interaction in the adsorption process, while physisorption is affected by the size and surface properties of plastic particles. A trend analysis indicates that carbon-based and metal-based adsorbents dominate the research landscape, with higher publication rates compared to biopolymer-based adsorbents. However, from an environmental perspective, biopolymer-based adsorbents are preferable due to their biodegradability, low toxicity, and renewable nature. This review discusses the mechanisms of these adsorbents, evaluates the limitations of current removal technologies, and outlines future research directions aimed at developing advanced and sustainable adsorbents to address the growing challenge of plastic pollution.
    Keywords:  Adsorbents; Adsorption; Bibliometric analysis; Microplastic; Nanoplastic; Remediation
    DOI:  https://doi.org/10.1016/j.envpol.2025.126658
  84. Ann Glob Health. 2025 ;91(1): 33
    Health Emergency Research Preparedness: An Analysis of National Pre‑COVID Research Activity and COVID Research Output.
    Peter H Kilmarx, Shirley Kyere.
      Background: Research capacity is a critical element of health emergency preparedness, but metrics are not readily available for many countries. The COVID‑19 pandemic provided an opportunity to use publicly available data to assess correlations between national pre‑pandemic research activity, pandemic research response, and other national socioeconomic characteristics. Methods: National pre‑pandemic (2018-19) research activity was defined as the average of percentile rankings of (1) the average annual number of health science publications in Scopus and (2) the average annual number of clinical trials in the International Clinical Trials Research Platform (ICTRP). National pandemic research response (2020-21) was defined as the average of percentile rankings of (1) average annual number of COVID‑19‑related publications in Scopus and (2) average annual number of COVID‑19‑related clinical trials in ICTRP. Findings: During 2018-19, the median (interquartile range [IQR]) of national annual average health science publications was 415 (108-3,398) and of clinical trials was 21 (4-273). During 2020-21, the median (IQR) of national annual average COVID‑19‑related publications was 85 (18-798) and that of COVID‑19‑related clinical trials was 1.5 (0-11). National COVID‑19‑related research output was strongly correlated with pre‑pandemic research activity (R‑squared 0.89) and much less correlated with Human Development Index (0.26), COVID‑19 case number (0.16), case rate (0.14), gross domestic product (0.11), or population (0.10). In a multivariable linear regression analysis, national pre‑COVID‑19 research activity was the only factor with substantial or statistically significant contribution to explaining variations in COVID‑19‑related research output. Interpretation: National pandemic research responses were most strongly correlated with pre‑pandemic research activity, much more so than with other country characteristics. These findings strongly support global efforts to strengthen research capacity as a critical element of preparedness for health emergencies.
    Keywords:  global health research; health emergency preparedness; research capacity; scientific output metrics
    DOI:  https://doi.org/10.5334/aogh.4764
  85. Sud Med Ekspert. 2025 ;68(3): 57-64
    [Analysis of dissertations on forensic medicine devoted to medical errors in cases of improper healthcare delivery over a 15-year period (2009-2023)].
    O D Yagmurov, V A Koryakina, V A Fetisov.
      Results of dissertational researches and scientific researches are traditionally referred to the main sources for improving the quality and level of forensic medical examinations.
    OBJECTIVE: To analyze the results of dissertational researches, completed by degree candidates in the «Forensic Medicine» specialty over a 15-year period (2009-2023), devoted to the analysis of medical errors in cases of improper healthcare delivery.
    MATERIAL AND METHODS: An analysis of 16 works (4 doctoral and 12 PhD dissertations), published on the official websites of medical universities and the Russian Center of Forensic Medical Expertise, was done. Sampling methods of bibliometric and scientometric analyses were used.
    RESULTS: Over a 15-year period, all authors published 379 articles, of which 21 (5.5%) were published in the «Forensic Medical Expertise» journal, 27 (7.1%) - in the «Medical Expertise and Law» journal, the overwhelming majority of articles were published in various medical subject collections, materials of research and practice conferences, congresses, including in 49 peer-reviewed medical journals recommended by the State Commission for Academic Degrees and Titles of the Ministry of Education and Science of the Russian Federation.
    CONCLUSION: Expert panel evidences on the «medical» cases indicate the need to expand and further develop joint scientific studies in such clinical disciplines as: «obstetrics and gynecology», «anesthesiology and resuscitation», «pediatric surgery», «oncology», «neonatology», «cardiology», «dentistry», «maxillofacial surgery», etc.
    Keywords:  defects in healthcare delivery; dissertational researches; forensic medical examination; improper healthcare delivery; medical errors
    DOI:  https://doi.org/10.17116/sudmed20256803157
  86. Eur J Vasc Endovasc Surg. 2025 Jun 14. pii: S1078-5884(25)00552-0. [Epub ahead of print]
    Evaluation of Sex Specific Representation and Sex Disaggregated Reporting in European Society for Vascular Surgery 2024 Clinical Practice Guidelines on the Management of Abdominal Aorto-iliac Artery Aneurysms.
    ESVS Consensus Group on Women With Arterial Vascular Disease
       OBJECTIVE: To evaluate the extent to which women are reported and represented within evidence supporting best practice recommendations for abdominal aortic aneurysms (AAAs).
    DATA SOURCES: Data were extracted from all studies supporting recommendation statements within the European Society for Vascular Surgery (ESVS) 2024 clinical practice guidelines on the management of abdominal aorto-iliac artery aneurysms (AAAs), including study type, journal, year of publication, country, funding, gender of authors, participant sex, demographics, use of a sex stratified main outcome, and sex disaggregated reporting.
    REVIEW METHODS: This was a PRISMA equity analysis (Prospero registration: CRD42024559537). Prevalence adjusted estimates (e.g., participation prevalence ratio [PPR]) were derived by dividing the proportion of women enrolled by the proportion of women expected in the disease population. Under-enrolment of women was defined as a PPR < 0.8. Binary logistic regression was used to evaluate factors associated with reporting of a sex stratified main outcome. Weighted linear regression was used to evaluate factors associated with an increased PPR for women.
    RESULTS: Of 160 guideline recommendations, 32 were consensus statements. The remaining 128 recommendations used evidence from 419 published studies, 30% (126/419) of which did not specify the overall number of women and men. Only 7% (31/419) reported a sex stratified main outcome and 11% (46/419) of studies presented sex disaggregated data. The odds of sex stratified reporting increased with a woman first author and with an increased PPR for women. Nearly 50% (141/293) of studies demonstrated under-enrolment of women. A higher journal impact factor, woman first author, more recent studies, and North American studies were associated with increased enrolment of women, while multinational studies, aortic specific studies, and woman last author were associated with decreased enrolment.
    CONCLUSION: Women are under reported and under represented in the evidence supporting ESVS AAA guideline statements. In depth evaluation is needed regarding best practice guidance for women and proportionate enrolment of women in AAA research should be encouraged.
    Keywords:  Abdominal aortic aneurysm; Gender; Guidelines; Sex
    DOI:  https://doi.org/10.1016/j.ejvs.2025.06.025
  87. Ophthalmol Glaucoma. 2025 Jun 13. pii: S2589-4196(25)00115-2. [Epub ahead of print]
    Female Authorship Trends in Ophthalmology Glaucoma.
    Sophia S Lam, Tak Yee Tania Tai, Nisha Chadha.
      Retrospective cohort study of 364 original publications in Ophthalmology: Glaucoma from 2018 to 2024. Proportion of female senior authors increased over 6 years, mirroring the increase in female board-certified ophthalmologists but the gap between female and male representation remains.
    Keywords:  academic medicine; authorship trends; female representation; glaucoma
    DOI:  https://doi.org/10.1016/j.ogla.2025.06.005
  88. Heliyon. 2025 May;11(10): e43392
    Erratum: Editor Note to "From theory to practice: Revealing the real-world impact of cognitive behavioral therapy in psychological disorders through a dynamic bibliometric and survey study".
    Hadi Dhafer Hassan Kariri.
      [This corrects the article DOI: 10.1016/j.heliyon.2024.e37763.].
    DOI:  https://doi.org/10.1016/j.heliyon.2025.e43392
  89. Front Pharmacol. 2025 ;16 1516882
    Analyzing collaboration dynamics in new drug R&D: A case study of two lipid-lowering drugs.
    Nan Zhang, Huaqing Guo, Mengchao Zhang, Chen Wang, Ruonan Tian, Yan Shi, Zhiguang Duan.
       Introduction: The advancements in biotechnology have ushered in a new age for drug development, characterized by increased collaborative efforts. Academic institutions, pharmaceutical firms, hospitals, foundations, and various other entities across different sectors are now joining forces more frequently to accelerate new drug innovation. However, there remains a limited understanding of how scientific and technological advancements are influencing these research collaborations.
    Methods: In this study, the development of two types of lipid-lowering drugs served as case studies. A detailed network analysis was performed at the levels of authors, institutions, and countries to quantify the evolutionary trends in research collaboration.
    Results: In the clinical research segment of the academic chain, papers resulting from collaborations tend to receive a higher citation count compared to other areas. However, there were notably fewer collaborative connections between authors transitioning from basic to developmental research and beyond. Collaboration models involving universities with enterprises, hospitals, or both are becoming more prevalent in biologics R&D. These models demonstrate effects of similarity and proximity. Additionally, there has been an increase in the involvement of developing countries in the research and development of new biologic drugs on a national and regional scale.
    Conclusion: New drug R&D research collaboration patterns evolve spontaneously with productivity updates. In the future, it is necessary to enhance the involvement of pharmaceutical companies in the basic research phase of new drug development, continuously strengthen the relationships across all segments of the academic chain, and thoroughly boost the efficiency of transforming new drug R&D into practical applications.
    Keywords:  academic chain; collaborative networks; new drug; research and development; research management
    DOI:  https://doi.org/10.3389/fphar.2025.1516882
  90. Sci Data. 2025 Jun 17. 12(1): 1014
    A multidimensional research productivity dataset of 21st-century Nobel Laureates in physiology or medicine.
    Wendy J Burnett, E Andrew Balas.
      We present a multidimensional dataset describing the research productivity of 21st-century Nobel Laureates in Physiology or Medicine from 2000 to 2023, focusing on their publications, patents, retractions, and funding before receiving the Nobel Prize. Examining the research outputs of eminent scientists offers a valuable resource for understanding patterns of productivity and collaboration that may have contributed to impactful scientific advancements. This dataset was created by conducting automated and manual searches of the internet using a variety of publicly available sources, including but not limited to the nobelprize.org website, PubMed, university web and profile pages, the United States Patent and Trademark Office, the NIH RePORTER database, Retraction Watch, and Clarivate. Each entry was meticulously matched to the laureate by cross-checking the above sources, collaborators, content, and production dates. Our unique dataset comprises 12,943 publications, 940 US patents, 17 retractions, and 2,094 peer-reviewed NIH awards produced before winning the Nobel Prize. The data provide multiple descriptors for practical purposes such as research productivity comparisons, national grant program design, or research policy development.
    DOI:  https://doi.org/10.1038/s41597-025-05278-0
  91. Cureus. 2025 May;17(5): e84438
    A Seven-Decade Analysis: What Does the Gender Breakdown of Award Recipients in the All India Ophthalmological Society Reveal?
    Sonia Phulke, Ashish Kumar, Priyanka Madaan, Amandeep Hans, Nidhi Malhotra.
      Introduction Professional awards and honors given by the medical societies help their members to boost their academic excellence and encourage leadership opportunities. The present study aimed to analyze the gender distribution of award recipients, identify any existing gender disparities, and assess factors influencing recognition in the field of ophthalmology. Methods This was an observational study with data extracted from the publicly available All India Ophthalmological Society (AIOS) website. Seventy-three years of data from the award recipients were reviewed. Individuals' gender was determined based on the first name and confirmed through internet searches of pronoun descriptors from professional websites. Key outcome measures were the gender distribution by year (1949-2022), category (achievement, scientific investigation/research, contribution to society/leadership, or lifetime achievement), and nomination type (self or society). Comparisons were made using Fisher's exact and chi-square tests when appropriate, with statistical significance set at a two-tailed P-value of <0.05. Results Of 452 award recipients across 31 AIOS award categories between 1949 and 2022, 323 recipients (71.5%) were men and 129 (28.5%) were women. Men received 96.7%, 78.6%, and 65.2% of awards in the contribution to society/leadership, achievement, and scientific investigation/research category, respectively, highlighting a significant underrepresentation of women in award distribution. Analysis of factors influencing gender distribution revealed that the award year, nomination type, and award category significantly impacted gender representation. Notably, fewer women were awarded before the start of the 21st century, and self-nominated candidates were predominantly skewed towards male recipients. Conclusion This study reveals significant gender disparities in award distribution within the Indian Ophthalmological Society. However, an increase in the proportion of female awardees over the years suggests a positive trend towards inclusivity.
    Keywords:  all india ophthalmological society; award; gender disparity; ophthalmology; women
    DOI:  https://doi.org/10.7759/cureus.84438
  92. Primates. 2025 Jun 18.
    Snapshots: most-cited Primates papers by decade (1950s-2020s).
    James R Anderson.
      
    DOI:  https://doi.org/10.1007/s10329-025-01203-6
  93. Eur J Orthop Surg Traumatol. 2025 Jun 17. 35(1): 250
    Exploring research knowledge and interests among Argentinian orthopedic trauma surgeons: a survey-based study to implement strategic tools for curricular development GAIA (Group for Support of Argentine Research).
    German Garabano, Sebastian Pereira, Lionel Llano, Danilo Taype Zamboni, Sebastian Gomez Tejada, Fernando Bidolegui.
       INTRODUCTION: Scientific research is the key to advancing a country's healthcare system, as it yields critical knowledge that can address specific clinical challenges and guide the development of effective healthcare strategies. In this context, orthopedic surgeons in Argentina established the Argentine Research Support Group (GAIA-Grupo de Apoyo a la Investigación de Argentina) to promote and support local research on musculoskeletal trauma. This study aimed to assess the level of training, interest, and barriers related to research among Argentine trauma surgeons.
    METHODS: A cross-sectional descriptive study was conducted using an anonymous and voluntary electronic survey (Microsoft Forms®) between August and November 2024. The survey consisted of six closed-ended questions, with simple (questions 1-4) and multiple (questions 5 and 6) response options. The first four questions investigated demographic characteristics and the number of publications, while the last two assessed training and interest in receiving specific research training. The Argentine Research Support Group (AO Trauma Latin America) designed the survey.
    RESULTS: A total of 467 (14.1%) responses were collected. Of these, 162 (35%) surgeons reported having published at least once, and 14 (3%) had received training on all survey topics. Regarding the reasons for not publishing (the remaining 305-65%), the most common responses were the lack of a research support group (29%) and insufficient protected time (28%). Concerning interest in receiving specific training, the most frequent responses were related to study design (56%), manuscript writing (58%), and external support from a research group (59%).
    CONCLUSION: This study highlights the low frequency of publications and the strong interest in participating in research studies among Argentine trauma surgeons. The lack of training and knowledge in essential research aspects and the absence of support groups were identified as modifiable barriers. Future educational and collaborative national and regional action plans must address this issue.
    Keywords:  Barriers; Research education; Research methodology; Scientific research; Scientific writing
    DOI:  https://doi.org/10.1007/s00590-025-04386-2
  94. Sci Data. 2025 Jun 17. 12(1): 1018
    PubMed knowledge graph 2.0: Connecting papers, patents, and clinical trials in biomedical science.
    Jian Xu, Chao Yu, Jiawei Xu, Vetle I Torvik, Jaewoo Kang, Mujeen Sung, Min Song, Yi Bu, Ying Ding.
      Papers, patents, and clinical trials are essential scientific resources in biomedicine, crucial for knowledge sharing and dissemination. However, these documents are often stored in disparate databases with varying management standards and data formats, making it challenging to form systematic and fine-grained connections among them. To address this issue, we construct PKG 2.0, a comprehensive knowledge graph dataset encompassing over 36 million papers, 1.3 million patents, and 0.48 million clinical trials in the biomedical field. PKG 2.0 integrates these dispersed resources through 482 million biomedical entity linkages, 19 million citation linkages, and 7 million project linkages. The construction of PKG 2.0 wove together fine-grained biomedical entity extraction, high-performance author name disambiguation, multi-source citation integration, and high-quality project data from the NIH Exporter. Data validation demonstrates that PKG 2.0 excels in key tasks such as author disambiguation and biomedical entity recognition. This dataset provides valuable resources for biomedical researchers, bibliometric scholars, and those engaged in literature mining.
    DOI:  https://doi.org/10.1038/s41597-025-05343-8
  95. Environ Sci Pollut Res Int. 2025 Jun 21.
    Correction to: Knowledge mapping on the sun‑induced chlorophyll fluorescence technology research: a scientometric and visualization analysis.
    Ming Li, Yang Wang, Na Li, Bin Chen, Shuren Chou.
      
    DOI:  https://doi.org/10.1007/s11356-025-36660-5
This page is being maintained by Thomas Krichel. It was last updated on 2025‒06‒28 at 1:48.