bims-evares Biomed News
on Evaluation of research
Issue of 2025–08–03
ninety papers selected by
Thomas Krichel, Open Library Society
  1. Global research on patient involvement in health technology assessment: a bibliometric analysis.
  2. Research Progress of Physiotherapy on Female Stress Urinary Incontinence: A Bibliometric Analysis.
  3. Global Research Progress of Mitochondria and Hypoxic-Ischemic Encephalopathy: A Comprehensive Bibliometric Analysis.
  4. Visual analysis of ovarian cancer immunotherapy: a bibliometric analysis from 2010 to 2025.
  5. The global academic distribution and changes in research hotspots of artificial intelligence in inflammatory bowel disease since 2000.
  6. The evolution of research in orthopedic robotic surgery: global trends and future directions.
  7. A bibliometric analysis of the published studies in ciprofol research.
  8. Bibliometric review of journal articles on pancreatic cancer: insights into productivity and impact.
  9. Research Trends and Hotspots in Female Pattern Hair Loss: A Bibliometric Study.
  10. Global Research Trends and Emerging Hotspots of RNF213 in Moyamoya Disease: A Bibliometric Analysis (2011-2024).
  11. Knowledge mapping and emerging trends in pediatric hemiplegia research: a bibliometric study spanning 1982-2025.
  12. Tracing the Rise of Galectin-3: A Global Bibliometric Insight Into Its Role in Heart Failure.
  13. Evaluation of the 100 Most-Cited Articles Published in Veterinary Journals.
  14. A bibliometric study of the most-cited research research articles and reviews in Naunyn-Schmiedeberg's Archives of Pharmacology (1969-2024).
  15. Bibliometrics and visual analysis of the research status and trends of placenta accreta spectrum disorder over the past decade.
  16. Organic Acids in Aquaculture: A Bibliometric Analysis.
  17. Bibliometric and Visualized Analysis of Gut Microbiota and Hypertension Interaction Research Published from 2001 to 2024.
  18. Current Research Focus and Trends of Remimazolam: A Bibliometric Analysis of the 100 Most Cited Articles.
  19. Magnetic resonance imaging for spinocerebellar ataxia: a bibliometric analysis based on web of science.
  20. Bibliometric and visualized analysis of the relationship between rheumatoid arthritis and periodontitis-related bacteria using CiteSpace software.
  21. A bibliometric analysis of synaptic plasticity and epilepsy from 2003 to 2023.
  22. [L'axe cerveau-intestin : l'aube des troubles neurologiques ?]
  23. An Analysis of the Bibliometrics of the Mexican Institute in Ophthalmology: A Case Study of an Emerging Research-Based Educational Health Institute.
  24. Bibliometric analysis of pancreatic cancer liver metastasis research: global trends, collaborations, and emerging research hotspots.
  25. Advancing lung organoids toward clinical applications: a global perspective on research focus and future directions.
  26. Mapping 74 years in acoustic analysis of voice disorders: A bibliometric review and future research directions.
  27. Research status and hotspots of oral frailty in older adults: a bibliometric analysis from 2013 to 2024.
  28. Research patterns in sports law and sports governance: a scopus bibliometric study.
  29. Bibliometric Analysis of Social Work Studies Published in WoS from Turkey.
  30. Trends in Mendelian randomization in neurological disease research: a bibliometric analysis.
  31. Trends and advances in cardiac rehabilitation for congenital heart disease: a bibliometric analysis.
  32. Application of non-invasive imaging in myocardial infarction: a bibliometric analysis from January 2003 to December 2022.
  33. Recent trend in phytoremediation of petroleum hydrocarbon contaminated soil: a bibliometric review.
  34. Integrating knowledge on diversity in nursing education: A bibliometric review of thematic trends and trajectories.
  35. Targeted therapy for Wilms tumor: a bibliometric study of worldwide scientific activity and collaborative networks.
  36. Research Trends and Knowledge Mapping of Opioid-Free Anesthesia: A Global Bibliometric Analysis.
  37. Forensic wound age estimation (2003-2024): evolving perspectives on tissue viability and molecular pathology.
  38. Bibliographic analysis of Taiwanese publications in the Web of Science Respiratory System Category from 1972 to 2023.
  39. Assessment of Productivity and Quality of Publications Derived From Doctoral Theses and the Scientific Performance of Graduates at a Romanian Medical and Pharmacy University.
  40. Trends and development of enhanced recovery after surgery programs in cranial and spinal neurosurgery.
  41. Advancements and trends in digestive system autotransplantation: a bibliometric and visualization analysis.
  42. Worldwide Research Trends on the Immunotherapy-Based Treatment of Ovarian Cancers: A Bibliometric and Visual Analysis.
  43. Androgen receptor as a potential therapeutic target in castration-resistant prostate cancer: a bibliometric analysis (2005-2024).
  44. Impact, Trends, and Visibility of Scientific Publications on Neurological Effects of COVID-19 Vaccine: A Scientometric Analysis.
  45. A comment on the search strategy in the sulcus vocalis bibliometric analysis.
  46. Five decades of teacher burnout research (1970-2024): A comprehensive bibliometric analysis.
  47. Tears, Tendons, and Trends: A Bibliometric Analysis on Anterior Cruciate Ligament Research.
  48. Application of monoclonal antibodies in diabetes: A bibliometric analysis from 2004-2024.
  49. Global research trends in surgical management of choledochal cysts: a bibliometric analysis from 2000 to 2024.
  50. Knowledge Structure and Evolution of Wetland Plant Diversity Research: Visual Exploration Based on CiteSpace.
  51. A bibliometric and visual analysis of Jak1 to explore trends and frontiers.
  52. A bibliometric analysis reveals a dynamic growth in the use of artificial intelligence in oral cancer research over three decades.
  53. Evolution of journal rankings in orthopedics and sports medicine (2000-2024) : A SCImago-based bibliometric analysis.
  54. Advance in the use of Artificial Intelligence of Pulmonary nodule: evolution, trends, and future directions.
  55. Quantitative analysis and evaluation of research on the application of computer vision in sports since the 21st century.
  56. Natural Products for Drug Discovery in Cognitive Disabilities: Bibliometric Hotspots, Research Trends, Conceptual Framework, and Future Directions.
  57. Frailty in Alzheimer's disease: A bibliometric analysis of research hotspots, emerging trends, and knowledge structure.
  58. Publication Trends of Integrated Plastic Surgery Residency Applicants Without Numeric Step 1 Scores.
  59. Global Trends in Non-Invasive Techniques for the Diagnosis and Monitoring of Nonalcoholic Fatty Liver Disease: A Bibliometric and Visualization Analysis.
  60. Biomaterial-driven regenerative drug delivery: a vicennial bibliometric landscape.
  61. Global Research Trends on Water Contamination by Microorganisms: A Bibliometric Analysis.
  62. Pharmacoepidemiologic Research Based on Common Data Models: Systematic Review and Bibliometric Analysis.
  63. Neuromodulation Interventions for Language Deficits in Alzheimer's Disease: Update on Current Practice and Future Developments.
  64. Knowledge domains and hotspots in corticosteroid use for cardiac surgery: a 23-Year bibliometric and visualized analysis.
  65. Exploring Multifactorial Conflicts and Resolution Strategies in the Field of Peri-Implant Osseointegration: A Study Based on the WOE-NLP-Delphi Framework and Bibliometrics.
  66. Mapping the landscape of machine learning in chronic disease management: A comprehensive bibliometric study.
  67. Global trends, hotspots and future prospects of ecological resilience of coastal wetlands: A bibliometric analysis.
  68. Bibliometric insights into transforming the management of rheumatoid arthritis: three decades of progress against opportunistic infections.
  69. Nutritional interventions in muscle hypertrophy research: a scientometric analysis within the context of resistance training (1992-2025).
  70. GeoBM: A Python-based tool for integrated visualization of global bibliometric data.
  71. Variability in article processing charges of open-access publishing across medical specialties.
  72. Advances in Radiotherapy and Chemoradiotherapy for the Treatment of Gastric Cancer (2014-2023): A Scientometric Approach.
  73. Impact Factor Insights 2025: Analysis of Pakistani Academic Journals.
  74. Dental fear and dental anxiety: bibliometric analysis of the 100 most frequently cited papers.
  75. Near-Death Experiences: A Bibliometric and Systematic Review of Published Literature From 1977 to 2025.
  76. Correction: A bibliometric analysis of studies related to the nuclear factor kappa b signaling pathway in knee osteoarthritis between 2004 and 2023.
  77. Mapping the Global Research on Drug-Drug Interactions: A Multidecadal Evolution Through AI-Driven Terminology Standardization.
  78. Research hotspots and trends in Spartina alterniflora studies (1970-2023): A bibliometric analysis.
  79. Commentary: Bibliometric analysis of targeted immunotherapy for osteosarcoma-current knowledge, hotspots and future perspectives.
  80. Global Trends in Vitamin D Research From 1985 to 2024.
  81. Exploring research frontiers and emerging trends of tyrosine kinase inhibitors in the treatment of colorectal cancer.
  82. Most Cited Articles in 2024.
  83. Bibliometrics and Visualization Analysis of Three Obligate Organohalide Respiring Bacteria Genera: A Systematic Review.
  84. Bibliometrics and altmetrics in the context of traditional, complementary, and integrative medicine.
  85. Anais Brasileiros de Dermatologia - Impact Factor and CiteScore for 2024⋆.
  86. Representation of Women as Editors of the Top Surgery Journals in the World.
  87. Editorial Comment for "GLOBAL COLLABORATION IN UROLOGICAL SURGERY RESEARCH BETWEEN HIGH- AND LOW-INCOME COUNTRIES: A BIBLIOMETRIC SCOPING REVIEW".
  88. Attrition in Academic Research Among Plastic Surgeons: A Longitudinal Cohort Study Across 3 Decades.
  89. Resident Scholarly Activity and Productivity Outcomes Before and After Implementing a Structured Research Program: A Before-After Study.
  90. Knowledge transfer, knowledge gaps, and knowledge silos in citation networks.
  1. Glob Health Res Policy. 2025 Jul 25. 10(1): 30
    Global research on patient involvement in health technology assessment: a bibliometric analysis.
    Chunlu Yu, Yan Huang, Huamei Wu, Luying Zhang.
       BACKGROUND: Patient involvement in health technology assessment (HTA) has been extensively explored and implemented in high-income countries, but little is known about it in low- and middle-income countries (LMICs). This study aimed to provide a comprehensive picture of the current state and trends of patient involvement in HTA research, which can inform future research in the LMICs.
    METHODS: Publications on patient involvement in HTA from January 1, 1900, to December 31, 2023, were retrieved from the core databases of the Web of Science. We applied a bibliometric analysis to reveal the collaboration patterns, hot topics, and evolution of the research field. Co-occurrence, clustering, citation, and burst analyses were performed using VOSviewer and CiteSpace, with results visualized for interpretation.
    RESULTS: A total of 175 articles were eligible for inclusion. The first valid article was published in 2000. The number of publications has increased since 2011. The most productive countries and institutions were Canada and McMaster University. The studies focused on five hot topics: patient preferences, priority setting, qualitative research, drug development, and hospital-based HTA. The burst analysis revealed that priority setting and cost effectiveness were the research frontiers.
    CONCLUSIONS: While patient involvement in HTA research has gained increasing attention, the research conducted in the LMICs remain limited. It is recommended that LMICs participate in international research collaborations, and focus on the five hot topics and emerging frontiers to advance both their research capacity and practical implementations.
    Keywords:  Bibliometric analysis; CiteSpace; Health technology assessment; Patient involvement; VOSviewer
    DOI:  https://doi.org/10.1186/s41256-025-00431-z
  2. Physiother Res Int. 2025 Jul;30(3): e70092
    Research Progress of Physiotherapy on Female Stress Urinary Incontinence: A Bibliometric Analysis.
    Wei Su, Han-Hong Jiang, Yu-Xiao Sun, Run-Ting Ma, Qiang Gao.
       BACKGROUND AND PURPOSE: Stress urinary incontinence (SUI) is characterized by the involuntary leakage of urine on physical activities or sneezing or coughing. Despite a considerable number of studies on physiotherapy for female SUI have been published, a bibliometric analysis that comprehensively quantifies and summarizes these studies is still lacking. Thus, the aim of this study is to summarize the current state of this area based on bibliometrics and to suggest future research trends.
    METHODS: We searched literature in the Web of Science database from the inception to 11 August 2024 and extracted the information of countries, institutions, authors, journals, references and keywords. CiteSpace v 6.2.4, VOSviewer v 1.6.19, and Origin 2024 were used for analysis and visualization.
    RESULTS: A total of 447 papers, published between 1986 and 2024, were included. The annual publication number has increased on average. The United States ranked first in the publication numbers, but the New Zealand had the highest average article citations. The University of Otago and the International Urogynecology Journal published the highest number of literature. The author of Bo, K ranked first in terms of scientific productions. While, the paper with the highest citation numbers was published by Dumoulin, C (2018). The keywords "stress urinary incontinence," "women," and "pelvic floor muscle training" ranked in the top three on occurrence frequency. In trend topics analysis, the frontier topics may be identified as "sexual function," "laser therapy," and "internet-based treatment."
    CONCLUSIONS: This bibliometric analysis highlights the increasing research output on female SUI. Key research areas include pelvic floor muscle training, while emerging trends such as sexual function, laser therapy, and interest-based treatments suggest the need for future studies to explore innovative and patient-centered approaches to female SUI management.
    Keywords:  bibliometric analysis; hotspots; research trend; stress urinary incontinence
    DOI:  https://doi.org/10.1002/pri.70092
  3. J Child Neurol. 2025 Jul 28. 8830738251352218
    Global Research Progress of Mitochondria and Hypoxic-Ischemic Encephalopathy: A Comprehensive Bibliometric Analysis.
    Liyan Luo, Hong Zhang, Qiaozhi Jiang, Shaohe Hei, Min Li, Wenlong Zhang, Pengcheng Yang, Sixiang He, Feng Jiang, Qian Wang.
      BackgroundHypoxic-ischemic encephalopathy is a serious neurologic condition caused by reduced blood and oxygen supply to the brain, typically occurring during birth. Mitochondria play a crucial role in the pathophysiological mechanisms of hypoxic-ischemic encephalopathy, yet a comprehensive bibliometric analysis of this research area is lacking. This study aims to identify research hotspots and trends related to mitochondria and hypoxic-ischemic encephalopathy through a detailed bibliometric analysis.MethodsWe searched the Web of Science Core Collection for studies on hypoxic-ischemic encephalopathy and mitochondria published between 2004 and 2024. Using VOSviewer, Citespace, and the R package "bibliometrix," we conducted a comprehensive analysis to explore research trends, key topics, and collaborations.ResultsA total of 162 eligible articles were identified. The annual number of publications has increased over time, with peaks in recent years. The top contributing countries were China, the United States, and the United Kingdom, showing extensive international collaborations. Major institutions include Augusta University, Southern Medical University, and the University of the Basque Country. The leading journals were the International Journal of Molecular Sciences and Neurobiology of Disease. Keyword analysis highlighted neuroprotection, apoptosis, oxidative stress, and ferroptosis as primary research themes. Influential references with strong citation bursts were identified, indicating their impact on the field.ConclusionThis is the first bibliometric analysis of research on mitochondria and hypoxic-ischemic encephalopathy, highlighting key trends and hotspots. Our findings provide valuable insights into the development and direction of research in this field and emphasize the importance of mitochondria in understanding and potentially mitigating the impacts of hypoxic-ischemic encephalopathy.
    Keywords:  Citespace; VOSviewer; bibliometric analysis; hypoxic-ischemic encephalopathy; mitochondria
    DOI:  https://doi.org/10.1177/08830738251352218
  4. Front Med (Lausanne). 2025 ;12 1573512
    Visual analysis of ovarian cancer immunotherapy: a bibliometric analysis from 2010 to 2025.
    Yingjie Zhang, Yanyan Chen, Chunru Chen, Xiaohua Cheng, Yanan Peng, Juan Wang, Fuxia Li, Li Wenting.
      Research on immunotherapy for ovarian cancer is rapidly advancing, and harnessing the immune system to fight tumors is at the forefront of cancer treatment. This article aims to discuss the prospect and development trend of immunotherapy for ovarian cancer from the perspective of bibliometrics. Articles about tumor burden and immunotherapy were collected from the Web of Science Core Collection (WoSCC) (retrieved on 1 May 2025). R package "Bibliometrics" analyzes key bibliometric characteristics and creates a three-filed map to show the relationships between institutions, countries, and keywords. VOSviewer is used for co-author analysis, co-occurrence analysis, and visualization. CiteSpace calculates citation burst citations and keywords. A total of 1,449 publications were retrieved from 15 years of scientific research. The China and United States (US) published the most articles. The most productive journals were Cancer Immunology Immunotherapy and Journal for Immunotherapy of Cancer. The top institution with the highest output was HARVARD UNIVERSITY. In recent years, the hot keywords of strong citation burst strength were "dendritic cells," "monoclonal antibody," and "adoptive immunotherapy." This bibliometric analysis mapped a basic knowledge structure. The tumor burden and immunotherapy field is entering a rapidly growing stage and keeping its value for future research.
    Keywords:  CiteSpace; VOSviewer ovarian Cancer; bibliometric; hotspot; immunotherapy
    DOI:  https://doi.org/10.3389/fmed.2025.1573512
  5. Front Med (Lausanne). 2025 ;12 1600291
    The global academic distribution and changes in research hotspots of artificial intelligence in inflammatory bowel disease since 2000.
    Likang Xu, Jinzhao Zou, Chao Sun, Gong Chen, Sujun Gao.
       Background: Artificial intelligence (AI) has gained widespread attention because of its potential applications in the clinical management of inflammatory bowel disease (IBD). However, bibliometric analyses of the literature published in this field are currently lacking. This study aimed to characterize the development trends and identify research hotspots in the application of AI to IBD through a bibliometric approach.
    Methods: Literature related to the application of AI in IBD, published between 2000 and 2024, was retrieved from the Web of Science Core Collection. Microsoft Office Excel 2021 was used to analyze and visualize the annual number of publications. Charticulator was utilized to create country cross chord charts. CiteSpace was employed to visualize collaboration networks among authors, institutions, and countries, generate timeline visualizations and perform a burst analysis of references and keywords.
    Results: The bibliometric analysis included 1,136 publications published between the years 2000 and 2024. The number of annual publications showed a rapid growth trend. The USA (n = 337) and Harvard University (n = 47) had the most published papers. Stidham, Ryan (n = 21) published the highest number of articles. The core journals shaping the field included Scientific Reports, Inflammatory Bowel Diseases, and PLoS One. The timeline view and burst analysis of references and keywords revealed that the research hotspots focused on radiomics, endoscopy, natural language processing (NLP), and personalized medicine after 2020.
    Conclusion: A growing number of researchers have engaged in exploring the application of AI in IBD, with the USA contributing the most to this field. Currently, the research hotspots mainly involve radiomics, endoscopy, NLP, and personalized medicine. This study provides valuable information for researchers evaluating the application of AI in IBD.
    Keywords:  Crohn’s disease; Web of Science; artificial intelligence; bibliometric; inflammatory bowel disease; ulcerative colitis
    DOI:  https://doi.org/10.3389/fmed.2025.1600291
  6. J Robot Surg. 2025 Jul 28. 19(1): 433
    The evolution of research in orthopedic robotic surgery: global trends and future directions.
    Sarai Liz Anyaipoma Ore, Danitza Natalye Amancay Montes, Fabriccio J Visconti-Lopez.
      Robotic surgery enhances precision in orthopedic and trauma procedures like joint replacements and bone corrections using navigation, artificial intelligence, and preoperative planning. This study aims to describe the global scientific output on robotic surgery in orthopedics and traumatology indexed on the Web of Science database. A bibliometric analysis was conducted to assess productivity, impact, and scientific collaboration. A total of 793 articles related to robotic surgery in orthopedics and traumatology were identified across 65 journals. The highest number of publications occurred in 2024 (155 articles), with an annual growth rate of 21.85% and an average of 24.38 citations per article. Fares Sami Haddad was the most prolific author (28 publications), while also leading in total citations (6089). The United States was the most productive country (279 articles). The most productive journals included The Journal of Arthroplasty and Knee Surgery Sports Traumatology Arthroscopy, whereas journals with the greatest citation impact were The Bone & Joint Journal and Spine. The most cited study was by Jacofski et al. (2016), with 290 citations. Leading institutions included the Hospital for Special Surgery and the University of Pittsburgh. The most common keywords over the years were "arthroplasty," "accuracy," "navigation," and "robotic surgery," reflecting evolving trends from biomechanical precision to imaging and trauma evaluation. These findings provide a comprehensive overview of research trends in orthopedic robotic surgery, identify gaps in the existing literature, and suggest future directions for research and clinical innovation in this evolving field.
    Keywords:  Bibliometric analysis; Orthopedics ; Robotic Surgical Procedures; Scientific output; Traumatology
    DOI:  https://doi.org/10.1007/s11701-025-02603-y
  7. Medicine (Baltimore). 2025 Jul 25. 104(30): e43567
    A bibliometric analysis of the published studies in ciprofol research.
    Evidence in Cardiovascular Anesthesia (EICA) Group
       OBJECTIVE: Ciprofol (HSK-3486), a novel intravenous anesthetic with structural similarities to propofol, has shown promising pharmacokinetic (PK) and pharmacodynamic (PD) profiles; however, clinical data regarding its efficacy and safety remain limited. Because research on ciprofol is still in its infancy, this study uses bibliometric methods to examine the published literature and to highlight research trends, key topics, and future directions for its clinical applications.
    METHODS: We searched the Web of Science Core Collection (WoSCC) for English-language articles and reviews on ciprofol published from 2017 - the year it was first reported - through August 28, 2024. Two authors independently screened titles and abstracts for eligibility, discrepancies were resolved in consultation with a senior reviewer. The data, including publication details and citation metrics, were extracted and organized for analysis. We visualized the results with CiteSpace, GraphPad Prism, and Microsoft Excel.
    RESULTS: A total of 62 studies were included. Annual publications rose by 50% from 2021 to 2022 and by 83% from 2022 to 2023. China dominated the field, contributing 59 articles (95.16% of the total). Sichuan University and Liu X. were the most prolific institution and author, respectively. BMC Anesthesiology, Drug Design, Development and Therapy, Frontiers in Pharmacology, and Journal of Clinical Anesthesia were the 4 leading journals publishing ciprofol research. Frontiers in Pharmacology received the most citations (n = 71) and achieved an H-index of 4. Anesthesiology carried the highest 2022 impact factor (9.1), whereas Anesthesia and Analgesia accrued 48 citations. Safety, pharmacokinetics, and anesthesia were the most frequently studied aspects, whereas "critically ill patients," "injection," and "pain" emerged as recent research hotspots. Temporal analysis showed that key terms shifted from "pharmacokinetics" in 2021 to "general anesthesia" by 2022, while themes such as "critically ill patients" remained consistently relevant.
    CONCLUSION: This bibliometric analysis provides a comprehensive overview of ciprofol research, identifies key contributors, and reveals critical insights and gaps in the literature. Our findings underscore ciprofol's safety, efficacy, and optimal clinical use while highlighting current hotspots and challenges that should guide future research.
    Keywords:  bibliometric analysis; ciprofol; research trends
    DOI:  https://doi.org/10.1097/MD.0000000000043567
  8. Ann Pancreat Cancer. 2025 Mar 30. pii: 1. [Epub ahead of print]8
    Bibliometric review of journal articles on pancreatic cancer: insights into productivity and impact.
    Christopher Wu, Julia Adriana Kasmirski, Raj Roy, Zhixing Song, Quince-Xhosa D Gibson, Herbert Chen, J Bart Rose, Andrea Gillis.
       Background: Bibliometric review offers a comprehensive and quantitative evaluation of pancreatic cancer research, focusing on journal and author productivity. Despite significant efforts to improve pancreatic cancer outcomes and expand the literature on the topic, there is still insufficient data on influential journals and article impact measures to guide researchers through journal submissions. This article aims to evaluate research productivity and identify influential journals and authors within the field. Utilizing bibliometric indices like impact factor, h-index, and eigenfactor will facilitate the assessment process.
    Methods: A comprehensive search on July 1, 2023 in the Scopus database to identify articles related to pancreatic cancer. The search criteria included the keyword "Pancreatic Cancer" in the subject area of "Medicine", limited to English language articles published between January 1989 and December 2022. We calculated publication and citation counts at the article, journal, and first author levels, employing various measures of centrality. Statistical analysis was conducted using the Student t-test.
    Results: The search yielded 52,154 articles from 3,155 journals with total citations of 1,903,916. The journal with the largest median citations dealing solely with pancreatic cancer was the Annals of Surgery. The journal with the highest number of publications is Pancreas. Six of the top twenty most cited articles were treatment-related articles. Of the top 30 journals by article count, JAMA had the highest median citation count, 340 of 33 articles. The most cited authors list was not associated with high productivity, similarly, the most productive authors were not associated with a high rate of citations.
    Conclusions: This study offers valuable insights for researchers and institutions in guiding journal selections and themes identified as popular among the research community. It positively impacts the selection of appropriate journals to submit articles on the topic by easily identifying the most impactful and cited journals. The findings emphasize the growing interest in the field, the emergence of specialized journals, and a focus on treatment-related investigations. Overall, this analysis underscores the relevance of bibliometric approaches in advancing pancreatic cancer research.
    Keywords:  Pancreatic cancer; bibliometrics; pancreatic adenocarcinoma
    DOI:  https://doi.org/10.21037/apc-24-22
  9. J Cosmet Dermatol. 2025 Aug;24(8): e70369
    Research Trends and Hotspots in Female Pattern Hair Loss: A Bibliometric Study.
    Hongjuan Fu.
       BACKGROUND: Female pattern hair loss (FPHL) is a common yet understudied condition with significant psychosocial impacts. Understanding global research trends and emerging topics in FPHL is essential for guiding future investigations.
    AIMS: This bibliometric analysis aimed to provide an overview of key trends, influential contributors, and evolving research themes in FPHL from 1957 to 2024.
    PATIENTS/METHODS: Publications related to FPHL were retrieved from the Web of Science Core Collection. Bibliometric analysis and visualization were performed using VOSviewer, CiteSpace, and the R package "bibliometrix."
    RESULTS: The study analyzed 488 publications authored by 2165 researchers across 189 journals. The USA led in publication output and citations, followed by China and South Korea. Leading institutions included the Egyptian Knowledge Bank, University of Melbourne, and National Taiwan University. Shapiro Jerry was the most prolific author. The Journal of Cosmetic Dermatology had the highest publication count, whereas the Journal of the American Academy of Dermatology was the most cited. Keyword analysis identified emerging hotspots, such as "mechanisms," "management," and "safety," with growing interest in "scalp," "association," and "telogen effluvium."
    CONCLUSIONS: This study highlights the global research landscape of FPHL, emphasizing the focus on treatment efficacy, safety, and underlying mechanisms. Future research may prioritize accurate diagnostic methods and risk factor exploration.
    Keywords:  CiteSpace; alopecia; bibliometric analysis; female pattern hair loss
    DOI:  https://doi.org/10.1111/jocd.70369
  10. Brain Res Bull. 2025 Jul 29. pii: S0361-9230(25)00301-6. [Epub ahead of print] 111489
    Global Research Trends and Emerging Hotspots of RNF213 in Moyamoya Disease: A Bibliometric Analysis (2011-2024).
    Xiaozan Chang, Lei Wang.
       BACKGROUND: Moyamoya disease (MMD) is a rare, chronic cerebrovascular disorder characterized by progressive stenosis of the internal carotid arteries and the development of collateral vascular networks. Recent research has increasingly focused on the RNF213 gene to better understand its role in the pathophysiology of MMD. This study aims to assess global research trends, identify key contributors, and explore emerging research hotspots related to RNF213 and MMD.
    METHODS: A bibliometric analysis was performed on publications from 2011 to 2024, retrieved from the Web of Science Core Collection database. Data were analyzed and visualized using VOSviewer 1.6.20, CiteSpace 6.3.R1, and R 4.3.3.
    RESULTS: A total of 356 publications were identified, showing a rapid annual growth rate of 27.06%. Japan was the leading country in both publication output (137 publications) and citations (4,288 citations). Prominent institutions included Kyoto University (88 publications) and Tohoku University (65 publications). The journal Stroke had the highest citation impact (1,318 citations). Notable authors included Koizumi Akio (30 publications, 1,726 citations) and Fujimura Miki (28 publications, 1,422 citations). The term "variant" highlights the growing interest in genetic diversity, while "vascular disorders" reflects an increasing focus on the vascular components and pathological mechanisms of the disease.
    CONCLUSION: This bibliometric analysis underscores significant progress in understanding the genetic mechanisms and clinical features of MMD, particularly with regard to vascular issues and disease onset. Future research should incorporate multi-database analyses and expand the range of document types to offer a more comprehensive understanding of this evolving field.
    Keywords:  Bibliometric analysis; Genetic mutations; Moyamoya disease; RNF213; Vascular remodeling
    DOI:  https://doi.org/10.1016/j.brainresbull.2025.111489
  11. Front Neurol. 2025 ;16 1590937
    Knowledge mapping and emerging trends in pediatric hemiplegia research: a bibliometric study spanning 1982-2025.
    Xiaoli Li, Ya Guo, Lingchuan Niu.
       Background: Pediatric hemiplegia is a significant neurological condition that impacts motor function and quality of life. This bibliometric analysis aimed to evaluate research trends, collaboration patterns, and emerging topics in pediatric hemiplegia research.
    Methods: Publications were retrieved from the Web of Science Core Collection database spanning from 1982 to 2025. The analysis was conducted using VOSviewer, CiteSpace, and R-bibliometrix to examine contributions of countries, institutions, authors, journals, and keywords.
    Results: A total of 1,840 publications were analyzed, showing consistent growth with an annual growth rate of 8.69%. The United States emerged as the leading contributor with 393 publications, followed by Italy (137) and the United Kingdom (124), with strong international collaboration networks evident among 64 countries. The University of London demonstrated the highest institutional productivity with 142 publications, while Royal Children's Hospital showed the strongest collaborative connections. Developmental Medicine and Child Neurology ranked as the most productive journal with 195 publications and highest citation impact. Boyd RN and Gordon AM were identified as the most influential authors based on h-index metrics and collaboration strength. Keyword analysis revealed five distinct research clusters, with "alternating hemiplegia," "mutations," "classification," and "risk factors" emerging as current research hotspots since 2017.
    Conclusion: This bibliometric analysis provides a comprehensive overview of research progress and identifies key hotspots in pediatric hemiplegia research, revealing the field's evolution from basic clinical descriptions to advanced genetic and classification studies. These findings offer valuable insights for researchers and clinicians to understand current research priorities and guide future investigations in pediatric hemiplegia management and treatment strategies.
    Keywords:  bibliometric analysis; citation analysis; international collaboration; pediatric hemiplegia; research trends
    DOI:  https://doi.org/10.3389/fneur.2025.1590937
  12. Int J Vasc Med. 2025 ;2025 7431078
    Tracing the Rise of Galectin-3: A Global Bibliometric Insight Into Its Role in Heart Failure.
    Amjad Bani Hani, Alaa Tarazi, Lubna Alnatour, Ahmad Aburrub, Mohammad Hijah.
      Background: Heart failure (HF) is a growing clinical syndrome with high morbidity and mortality. Galectin-3, a key player in cardiac fibrosis and inflammation, has emerged as an important biomarker for HF. This bibliometric analysis is aimed at exploring global scientific output and research trends on the relationship between galectin-3 and HF. Methods: A bibliometric literature search was conducted on the Web of Science in September 2024. Microsoft Excel and VOSviewer were used for scientometric analysis and to visualize scientific achievements, including publication counts, key authors, countries, organizations, journals, and research hotspots in the field. Results: A total of 705 publications met the inclusion criteria after screening. Research on galectin-3 and HF is currently experiencing rapid growth. The United States, China, and the Netherlands produced the most articles, contributing approximately 55% (388/705) of all papers. Most institutions and authors were from the United States and the Netherlands, with the University of Groningen (Netherlands) being the top publishing institution. Key authors include De Boer RA, Januzzi JI, and Van Veldhuisen DJ. The European Journal of Heart Failure was the most cited journal and had the highest number of publications. Key research topics include the relationship between galectin-3 and HF prognosis, fibrosis, mortality, and conditions leading to HF. Conclusion: This is the first bibliometric analysis of publications on the association between galectin-3 and HF. This study provides researchers with valuable insights into the most influential articles on this biomarker and its role in HF. Key research areas focus on galectin-3 role in the diagnosis, pathology, and prognosis of various HF types, causes, and outcomes. Further research should explore how galectin-3 can facilitate earlier diagnosis of HF or fibrosis, with increased international collaboration among researchers.
    Keywords:  atherosclerosis; bibliometric; biomarker; galectin-3; heart failure
    DOI:  https://doi.org/10.1155/ijvm/7431078
  13. Vet Med Sci. 2025 Sep;11(5): e70545
    Evaluation of the 100 Most-Cited Articles Published in Veterinary Journals.
    Ender Uzabaci.
       BACKGROUND: The most frequently cited studies in a given field are those which are pioneering and have been widely accepted by the academic community. The aim of this study was to analyse the 100 most-cited articles published in veterinary journals bibliometrically.
    METHODS: The 100 most-cited articles were identified in the Web of Science database. These articles were bibliometrically examined and visualised. The association between average citations per year, years since publication, number of authors, journal impact factor and article length were assessed by Spearman's correlation analysis. Bibliometric analysis and mapping processes were performed using RStudio software.
    RESULTS: Amongst the 100 most-cited articles published between 1980 and 2016, the year 2000 had the highest number of publications (n = 8). The total number of citations ranged from 475 to 1638; the median citation number was 608.5. The most-cited paper was published in 2004 by Desjeux. The country with the most publications was the United States, with 48 articles. A total of 145 institutions contributed to the 100 most-cited papers, with the University of California having the most publications with 12 papers. There was a statistically significant negative correlation between the annual average number of citations and the years since publication (r = -0.769, p < 0.001). No significant relationship was found between the average yearly number of citations and other indicators.
    CONCLUSIONS: The present study provides insight into research in animal health, offering a comprehensive understanding of the trends and contributions of research in this field.
    Keywords:  animal health; citation analysis; publication; veterinary medicine
    DOI:  https://doi.org/10.1002/vms3.70545
  14. Naunyn Schmiedebergs Arch Pharmacol. 2025 Aug 01.
    A bibliometric study of the most-cited research research articles and reviews in Naunyn-Schmiedeberg's Archives of Pharmacology (1969-2024).
    Roland Seifert, Waseem Hassan.
      The objective of this study was to perform a comprehensive bibliometric analysis of the top 100 most-cited research research articles and the top 100 most-cited reviews published in Naunyn-Schmiedeberg's Archives of Pharmacology (NSAP) between 1969 and 2024. The Scopus database was systematically analyzed for research papers and reviews. Author performance for both research article and review groups was evaluated using multiple bibliometric indicators-total publications, citations, h-index, g-index, m-index, HG composite, and Q2 index-with detailed results presented in the supplementary files. Institutional contributions were also highlighted. Furthermore, co-word analysis of research article and review titles was conducted to identify prevailing thematic focuses. During this period, the journal published a total of 12,354 research articles, with publication trends showing notable fluctuations. A record high of 706 research articles was published in 2024. Germany led overall contributions with 4852 publications, followed by the USA (860), Japan (661), and China (507), with the latter demonstrating a steep rise in recent years. The top 100 most-cited research articles, published between 1970 and 2006, garnered an average of 262.5 citations each. Peak citation averages occurred in 1984 (456.67), 1979 (392.20), and 1986 (384.00), while the highest annual citation rates were recorded in 2006 (15.20), 2004 (10.91), and 1984 (10.87). These influential research articles, many of them in the field of neurotransmitter research, involved 314 authors, averaging 3.83 co-authors per paper, with 15% reflecting international collaborations. Germany (32), Sweden (16), and Switzerland (12) emerged as the leading contributing countries. Similarly, review publications demonstrated a steady increase over time, culminating in a sharp rise in 2024 with 227 reviews-out of a total of 560. India (142) and Germany (140) were the most prolific countries in review authorship, followed by the USA and Iran. The top 100 most-cited reviews, published from 1973 to 2023, averaged 132.2 citations per research article. Citation activity peaked in the early 2000 s, with a 2002 review receiving 545 citations and the year 2000 averaging 277.8 citations per review. Overall, NSAP has made substantial contributions in specific areas of research and more broadly with respect to reviews. Very substantial changes in geographic origin of papers occurred during the past two decades, reflecting internationalization. Our analysis provides the scientific basis for recently implemented "Collections and call for papers" on diverse topics and editorial policies regarding review papers. Thus, the bibliographic analysis of a journal can be effectively used as a tool to ensure its future existence and adapt to a changing scientific environment.
    Keywords:  Co-words analysis; Editorial policies; Most-cited reviews; Most-cited research articles; NSAP; Top contributors
    DOI:  https://doi.org/10.1007/s00210-025-04471-7
  15. J Matern Fetal Neonatal Med. 2025 Dec;38(1): 2537222
    Bibliometrics and visual analysis of the research status and trends of placenta accreta spectrum disorder over the past decade.
    Xinyan Li, Qiuying Li, Huiyun Hu, Xiaomei Li.
       OBJECTIVE: This study aims to perform a bibliometric analysis of the literature concerning placenta accreta spectrum disorders (PASDs) over the past decade, with the objective of elucidating the current status and developmental trends in global research. It seeks to systematically assess the associated risk factors, diagnostic methodologies and therapies of PASDs, thereby providing a foundation for enhancing diagnostic and management strategies.
    METHODS: The Web of Science database was utilized to retrieve literature pertaining to PASDs from 2015 to 2024. Employing data visualization tools such as Citespace, VOSviewer, and Bibliometric, this study analyzes various metrics including the number of publications, citation trends, contributions by countries and institutions, author influence, and journal distribution.
    RESULTS: A total of 1860 English-language articles were included in the analysis. Over the past decade, the number of publications reached a peak of 271 in 2021, and the citation rate also increased steadily. The United States and China have emerged as the principal contributors to research in this area, with Baylor College of Medicine demonstrating the highest research output. According to the analysis of author contribution, Fox KA is the leading author in the number of publications, and Jauniaux E is the most cited author. The top journals include "Journal of Maternal-Fetal & Neonatal Medicine" and "American Journal of Obstetrics and Gynecology". In addition, keyword analysis revealed the evolution and development of topics related to placenta implantation, such as "diagnosis", "complications", "management", etc.
    CONCLUSION: This study highlights the need for early identification and multidisciplinary collaboration in PASDs management. Maternal and infant outcomes will improve with advances in early diagnostic techniques, optimized management strategies, and exploration of new treatments. In the future, maintaining a focus on the latest researches and guideline updates in this field is crucial.
    Keywords:  Placenta accreta spectrum disorders; VOSviewer; bibliometrics; citespace; visual analysis
    DOI:  https://doi.org/10.1080/14767058.2025.2537222
  16. Foods. 2025 Jul 17. pii: 2512. [Epub ahead of print]14(14):
    Organic Acids in Aquaculture: A Bibliometric Analysis.
    Gidelia Araujo Ferreira de Melo, Adriano Carvalho Costa, Matheus Barp Pierozan, Alene Santos Souza, Lessandro do Carmo Lima, Vitória de Vasconcelos Kretschmer, Leandro Pereira Cappato, Elias Marques de Oliveira, Rafael Vilhena Reis Neto, Joel Jorge Nuvunga, Jean Marc Nacife, Mariana Buranelo Egea.
      Fish production faces various challenges throughout its cycle, from rearing to consumption. Organic acids have emerged as an effective fish feed and meat treatment solution. They promote health and well-being, control pathogens, improve digestion, and contribute to food preservation. This study was therefore carried out to evaluate the evolution of publications on the use of organic acids in aquaculture over time, identifying the leading journals, authors, countries, and relevant organizations associated with the publications and determining the keywords most used in publications and research trends on this type of accommodation using bibliometric analysis. For this analysis, the Web of Science (WoS) and Scopus databases were used, with the keywords and Boolean operators "organic acid*" AND ("pathogens" OR "microorganism*" OR "bacteria" OR "fungi") AND ("fish" OR "fry" OR "pisciculture"). Ninety-six articles were found in 44 journals, with the participation of 426 authors and 188 institutions, from 1995 to 2024. The most crucial publication source with the highest impact factor was the journal Aquaculture, with 14 articles, 2 of which were written by the most relevant author, Koh C., who received the highest number of citations and had the highest impact factor among the 426 authors. China had the most scientific production, with 26 publications on organic acids in aquaculture. However, Malaysia was the country that published the most cited documents, a total of 386. The most relevant affiliation was the University of Sains Malaysia, which participated in the publication of eight articles. The 10 most frequent keywords were fish, organic acids, citric acid, article, bacteria, growth, microorganisms, Oncorhynchus mykiss, animals, and digestibility. The results indicate increased publications on the benefits of using organic acids in aquaculture, highlighting their effectiveness as antibacterial agents and promoters of zootechnical development. However, gaps still require more in-depth research into the ideal dosages, mechanisms of action, and long-term impacts of these compounds.
    Keywords:  antimicrobials; fish farming; inactivators; microorganisms; pathogens
    DOI:  https://doi.org/10.3390/foods14142512
  17. Microorganisms. 2025 Jul 18. pii: 1696. [Epub ahead of print]13(7):
    Bibliometric and Visualized Analysis of Gut Microbiota and Hypertension Interaction Research Published from 2001 to 2024.
    Jianhui Mo, Wanghong Su, Jiale Qin, Jiayu Feng, Rong Yu, Shaoru Li, Jia Lv, Rui Dong, Yue Cheng, Bei Han.
      A comprehensive bibliometric analysis of literature is imperative to elucidate current research landscapes and hotspots in the interplay between gut microbiota and hypertension, identify knowledge gaps, and establish theoretical foundations for the future. We used publications retrieved from the Web of Science Core Collection (WoSCC) and SCOPUS databases (January 2001-December 2024) to analyze the annual publication trends with GraphPad Prism 9.5.1, to evaluate co-authorship, keywords clusters, and co-citation patterns with VOSviewer 1.6.20, and conducted keyword burst detection and keyword co-occurrence utilizing CiteSpace v6.4.1. We have retrieved 2485 relevant publications published over the past 24 years. A 481-fold increase in global annual publications in this field was observed. China was identified as the most productive country, while the United States demonstrated the highest research impact. For the contributor, Yang Tao (University of Toledo, USA) and the University of Florida (USA) have emerged as the most influential contributors. Among journals, the highest number of articles was published in Nutrients (n = 135), which also achieved the highest citation count (n = 5397). The emergence of novel research hotspots was indicated by high-frequency keywords, mainly "hypertensive disorders of pregnancy", "mendelian randomization", "gut-heart axis", and "hepatitis B virus". "Trimethylamine N-oxide (TMAO)" and "receptor" may represent promising new research frontiers in the gut microbiota-hypertension nexus. The current research trends are shifting from exploring the factors influencing gut microbiota and hypertension to understanding the underlying mechanisms of these factors and the potential therapeutic applications of microbial modulation for hypertension management.
    Keywords:  bibliometric analysis; gut microbiota; hypertension; research hotspots
    DOI:  https://doi.org/10.3390/microorganisms13071696
  18. Curr Neuropharmacol. 2025 Jul 24.
    Current Research Focus and Trends of Remimazolam: A Bibliometric Analysis of the 100 Most Cited Articles.
    Yunying Chen, Junting Wu, Huangyi Chen, Chenxing Lei, Dezhao Liu, Ying Wang.
       INTRODUCTION: Remimazolam is a novel benzodiazepine derivative with advantages such as prompt onset, short duration of action, fast recovery, and non-organ dependence. Numerous studies have been conducted on remimazolam. However, bibliometric analysis on high-quality and highly cited articles related to remimazolam is lacking. The objective of this article is to evaluate the current research status and prevailing trends regarding the most frequently cited articles on remimazolam, utilizing bibliometrics.
    METHODS: Studies related to remimazolam were searched in the Web of Science core database. The search period ranged from the inception of the database to April 2025, and 100 highly cited research articles were selected. The researchers gathered and analyzed pertinent data from the studies and subsequently conducted visual analysis utilizing VOSviewer and CiteSpace.
    RESULTS: The total number of citations for the top 100 highly cited studies was 6683, published between 2010 and 2024. China, the United States, and the United Kingdom contributed the majority of these studies. These studies were published in 47 different journals. The journal with the highest number of publications was the Journal of Anesthesia. The institution with the highest publication volume was PAION DEUTSCHLAND GMBH in Germany, and the author with the highest contribution was Schippers F. The pharmacokinetics, pharmacodynamics, safety, and efficacy of remimazolam were the main research directions and focuses in the field.
    DISCUSSION: Our analysis of the top 100 cited remimazolam papers reveals a rapidly advancing field. The surge in high-quality clinical studies confirms remimazolam's practical edge over older agents, such as propofol, particularly in offering better blood pressure stability for older patients and fewer breathing problems during procedures like endoscopy. While these advantages position it as a strong contender, important questions linger about its use in people with severe liver or kidney issues due to how it is broken down, and its effects on delirium remain unclear. Broadening research globally and focusing on these specific patient groups, as well as long-term safety, will be key to realizing remimazolam's full clinical potential.
    CONCLUSION: This study analyzed the 100 most frequently referenced articles on remimazolam, providing valuable insights into the characteristics and focal areas of research related to this topic.
    Keywords:  Bibliometric analysis; CiteSpace.; VOSviewer; Web of Science; bibliometrics; most-cited articles; remimazolam
    DOI:  https://doi.org/10.2174/011570159X370775250704060228
  19. Front Neurol. 2025 ;16 1512800
    Magnetic resonance imaging for spinocerebellar ataxia: a bibliometric analysis based on web of science.
    Zhen-Yi Liu, Lin Zhang, Zhao-Di Wang, Zi-Qiang Huang, Meng-Cheng Li, Yan Lu, Jian-Ping Hu, Qun-Lin Chen, Xin-Yuan Chen.
      The objective of this study was to review the history of magnetic resonance imaging (MRI) research on spinocerebellar ataxia (SCA) over the last 16 years. We conducted a comprehensive bibliometric analysis of relevant scientific literature that explores the use of MRI in studying SCA using CiteSpace. A total of 761 scientific manuscripts, published between January 2009 and March 2025 and available in the Web of Science (WoS) database, were included in this analysis. A total of 197 out of 761 articles were analyzed using CiteSpace to determine the number and centrality of publications, countries, institutions, journals, authors, cited references, and keywords related to MRI and SCA. Overall, the number of publications that use MRI to study SCA has gradually increased over the years. The United States, China, Italy, Germany, and Brazil are at the forefront in this research field; a total of 420 authors from 317 research institutions in these nations have published articles in neuroscience-related journals. Among the most cited publications are an article by Rezende et al. on brain structural damage in SCA3 patients and an review by Klockgether et al. on spinocerebellar ataxia. The keyword "spinocerebellar ataxia" has the highest frequency of occurrence. However, "feature" may become a research hotspot in the coming years based on the analysis of the keyword's citation burst. The findings of this bibliometric study provide a summary of the last 16 years of SCA research using MRI technology. More importantly, the present study identifies current trends and future research hotspots in the field, helping researchers to identify new and unexplored research areas.
    Keywords:  CiteSpace; bibliometrics; magnetic resonance imaging; spinocerebellar ataxia; spinocerebellar ataxia type 3
    DOI:  https://doi.org/10.3389/fneur.2025.1512800
  20. Front Microbiol. 2025 ;16 1589331
    Bibliometric and visualized analysis of the relationship between rheumatoid arthritis and periodontitis-related bacteria using CiteSpace software.
    Tianqiong Lin, Zehong Xu, Jiali Chen, Xiaoyu Wang, Qiaoping Li, Biying Ye, Chaoyan Hu.
       Background: Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease of unknown etiology. Recent studies have indicated a potential relationship between the oral microbiome and the onset and progression of RA. However, research trends in this area have not been comprehensively examined. The aim of this study was to conduct a bibliometric analysis of the relationship between RA and the oral microbiome from January 1, 1995, to January 10, 2024, to elucidate the research landscape, including hot topics and emerging trends.
    Methods: We extracted literature related to RA and the oral microbiome from the Web of Science database. Utilizing CiteSpace software, we analyzed publications, countries, institutions, authors, and keywords through a visual knowledge graph to assess research hotspots and trends.
    Results: In total, 833 articles were identified, revealing a consistent increase in the number of annual publications in this field over the study period. The United States has emerged as the leading country in terms of publication volume, with Harvard University being the most prolific institution. Among the authors, Jan Potempa has the highest number of publications. Keyword analysis indicated that current research hotspots concerning the relationship between RA and the oral microbiome primarily focus on Porphyromonas gingivalis, periodontitis, inflammation, expression, and peptidylarginine deiminase. Investigating the mechanisms by which oral and intestinal microorganisms influence RA, as well as developing intervention strategies targeting these microbiotas, is anticipated to be a significant future research direction.
    Conclusion: This study characterized the trends in the literature regarding the relationship between RA and the oral microbiome, providing valuable insights for scholars pursuing further research.
    Keywords:  Porphyromonas gingivalis; bibliometrics; inflammation; oral microbiome; rheumatoid arthritis
    DOI:  https://doi.org/10.3389/fmicb.2025.1589331
  21. Front Neurol. 2025 ;16 1533268
    A bibliometric analysis of synaptic plasticity and epilepsy from 2003 to 2023.
    Xuewei Li, Huaiyu Sun, Zhiqing Chen, Hongmei Meng, Daguang Zhang.
       Background and purpose: Epilepsy is a prevalent and chronic neurological disorder. Recent studies suggest that synaptic plasticity could be a promising therapeutic target for epilepsy. This research employed bibliometric techniques to assess the study trends of synaptic plasticity in epilepsy over the last 20 years, highlighting major areas of focus and new topics.
    Methods: Research articles on synaptic plasticity in epilepsy, spanning 2003 to 2023, were sourced from the Web of Science Core Collection (WoSCC) database. Tools including CiteSpace, VOSviewer, and various online bibliometric platforms were utilized to conduct a deeper analysis of the collected data.
    Results: From 2003 to 2023, a total of 1,060 publications related to synaptic plasticity in epilepsy were indexed, including 309 review articles. Over the past two decades, both the number of publications and their citations have increased. The United States emerged as the leading country in terms of the number of both review and original research articles published, highlighting its significant influence in this field. Among all authors, Fabio Benfenati was the most cited in review articles, while Xuefeng Wang was the most cited in original research articles. Over the past 20 years, Frontiers in Cellular Neuroscience published the highest number of review articles on synaptic plasticity in epilepsy, while The Journal of Neuroscience published the most original research articles on this topic.
    Conclusion: This research examined 1,369 studies on synaptic plasticity in epilepsy and highlighted the prevailing trends in the field. The research findings indicate that the current focus of review studies is on gamma-aminobutyric acid, amyloid beta peptide, and glutamate receptors, while the focus of original research is on astrocytes, NMDA receptors, and long-term potentiation.
    Keywords:  CiteSpace; VOSviewer; bibliometric analysis; epilepsy; synaptic plasticity; visualization
    DOI:  https://doi.org/10.3389/fneur.2025.1533268
  22. Ann Biol Clin (Paris). 2025 Aug 01. 83(4): 0
    [L'axe cerveau-intestin : l'aube des troubles neurologiques ?]
    Hailong Wu, Fengming Zhao, Wenzhi Jia, Peng Li.
      Over the past two decades, the brain-gut axis has received increasing scholarly attention. However, few bibliometric analyses have systematically examined this area. We aimed to visualize the current status of research in this field, summarize hotspots, and present trends through a bibliometric analysis of published publications related to the brain-intestinal axis. Publications about the brain-gut axis were selected from the Web of Science Core Database (WoSCC) database. Countries/regions, institutions, authors, journals, references, and keywords in this field were visually analyzed using VOSviewer and CiteSpace software. A total of 3320 publications were eventually retrieved from 2000 to 2021. Publications on the brain-gut axis have increased year by year, especially in the last decade. The United States was the most prolific country (943, 28.404%), while Ireland was the country with the highest average number of article citations (156.03). Before 2011, most studies focused on the brain-gut axis, with irritable bowel syndrome being the most studied disorder; whereas in the last decade, most studies focused on the gut-brain axis, especially the microbial gut-brain axis, with neurodegenerative disorders being the most studied. In terms of global trends, research on the brain-gut axis is booming. Moreover, the role and therapeutic applications of the microbial-gut-brain axis in the progression of central nervous system (CNS) diseases, especially neurodegenerative diseases, are the focus of current research and future research trends.
    Keywords:  CiteSpace; VOSviewer; bibliometrics; gut microbes; gut-brain axis
    DOI:  https://doi.org/10.1684/abc.2025.1981
  23. Med Ref Serv Q. 2025 Jul 28. 1-15
    An Analysis of the Bibliometrics of the Mexican Institute in Ophthalmology: A Case Study of an Emerging Research-Based Educational Health Institute.
    Van Charles Lansingh, Ellery Lopez, Juan E Gallo, Jared J Tuttle, Marina Banuet-Martinez.
      The Instituto Mexicano de Oftalmología (IMO), a non-profit eye institute, has experienced significant growth. In this case study, we analyze IMO-affiliated publications (2012-2023) and introduce the Degree of Involvement in paper authorship index (DI-index). Journal metrics were extracted from InCites Journal Citation Reports and Scimago. IMO research output grew from one publication (2012) to 31 (2023), peaking at 45 (2018). The average impact factor rose from 0.2 (2012) to 5.2 (2022). The DI-index totaled 106.6 across 227 articles. Bibliometric analysis provides valuable insights for emerging institutions, and the DI-index provides a novel approach to evaluating authorship involvement.
    Keywords:  Authorship; DI-index; Global South; bibliometrics; case study; global health; impact factor; ophthalmology
    DOI:  https://doi.org/10.1080/02763869.2025.2533771
  24. Front Oncol. 2025 ;15 1546400
    Bibliometric analysis of pancreatic cancer liver metastasis research: global trends, collaborations, and emerging research hotspots.
    Yingjie Huang, Zhijie Yin, Wei Han.
       Background: Pancreatic cancer liver metastasis (PCLM) is a critical condition characterized by the spread of pancreatic cancer to the liver, significantly contributing to cancer-related mortality. The importance of understanding the epidemiology and research trends in PCLM cannot be overstated, as it impacts the development of effective treatment strategies and patient care in oncology.
    Method: This study provides a comprehensive epidemiological and bibliometric analysis of PCLM research. Advanced visualization tools such as VOSviewer, CiteSpace, and the R package "bibliometrix" were utilized to analyze the literature. A total of 3,941 publications were identified, covering a 15-year period from 2010 to 2024. The methodology included the identification of publication trends, country and institutional contributions, leading journals, and keyword co-occurrence analysis to uncover research hotspots.
    Results: The annual publication counts exhibited an upward trend, peaking at 384 in 2024, indicating a growing interest in PCLM research. The research included contributions from 90 countries and 4386 institutions, with China and the United States being the most prolific. The journal Cancers was identified as the most frequent publisher in this field. Keyword co-occurrence analysis revealed "cancer" and "pancreatic cancer" as key research hotspots, with a focus on prognostic factors and therapeutic strategies. The study also highlighted the importance of international collaboration and identified key contributors in the field.
    Conclusion: The findings of this study reveal the significant increase in PCLM research output, emphasizing the need for continued investigation and collaboration to improve treatment outcomes and patient care. While the study is limited by its reliance on bibliometric data without experimental validation, it nonetheless provides valuable insights into publication trends and emerging research themes in PCLM. The results underscore the importance of further research to enhance our understanding of this challenging area of oncology and to guide future research directions.
    Keywords:  bibliometric analysis (BA); global progress; liver metastasis; pancreatic cancer; research trends
    DOI:  https://doi.org/10.3389/fonc.2025.1546400
  25. Front Med (Lausanne). 2025 ;12 1611304
    Advancing lung organoids toward clinical applications: a global perspective on research focus and future directions.
    Qian Wang, Shiyan Tan, Xi Fu, Jiawei He, Qiong Ma, Fengming You, Liting You, Yifeng Ren.
       Background: Lung organoids have emerged as a promising tool for studying lung development, function, and disease pathology. The present study aimed to analyze the current status and development trends of lung organoid research over the past years, present visual representations, and provide references for future research directions using bibliometric analysis.
    Methods: Information on articles on lung organoids extracted from the Web of Science Core Collection, such as year of publication, journal, country, institution, author, and keywords, was analyzed. R, VOSviewer, and SCImago Graphica were used to visualize publication trends, co-authorship analysis, co-occurrence analysis, and hotspot evolution.
    Results: The number of global publications has increased from 1 in 2011 to 929 in 2024. The Nature produced the highest number of citations (2,675 citations). The United States (8,155 citations and 281 publications), University Medical Center Utrecht (2083 citations and 11 publications), and Clevers H (2,711 citations and 21 publications) were the most influential countries, institutions, and authors, respectively. Co-occurrence cluster analysis of the top 54 keywords formed four clusters: (1) idiopathic pulmonary fibrosis, (2) lung cancer, (3) cystic fibrosis, (4) COVID-19.
    Conclusion: Overall, research on lung organoids continues to increase. The United States of America and the Netherlands dominated global studies. The analysis of pulmonary fibrosis, lung cancer and COVID-19 occupied a prominent position of research in this area. The research hotspots for lung organoids are disease model and microphysiological systems. Standardization, accurate disease modeling, and ethics and safety remain pressing challenges that need to be addressed in this field.
    Keywords:  bibliometric; clinical applications; future directions; lung organoids; research focus
    DOI:  https://doi.org/10.3389/fmed.2025.1611304
  26. J Commun Disord. 2025 Jul 11. pii: S0021-9924(25)00062-0. [Epub ahead of print]117 106555
    Mapping 74 years in acoustic analysis of voice disorders: A bibliometric review and future research directions.
    Ahmed M Yousef, Lady Catherine Cantor-Cutiva, Eric J Hunter.
       PURPOSE: This paper conducts a bibliometric analysis to identify and examine the strengths, gaps, and trends in research on acoustic voice assessment for voice disorders.
    METHODS: A bibliometric analysis was performed on journal articles about voice disorders and acoustic voice assessment in English, Spanish, and Portuguese using seven indexed databases. The analyzed bibliometric parameters included publication year, authors, institutions, countries, journals, subject areas, and keywords. VOSviewer software was used for keyword co-occurrence analysis and authorships network analysis. The initial search yielded 6532 publications, with 1253 relevant papers after screening (1951-2024).
    RESULTS: Publications in acoustic voice assessment had 74 years of exponential growth (25 % published after 2021). The publishing journals covered 80 categories and subjects. Artificial Intelligence, though recent, was among the top journal subjects. Health conditions like dementia, Alzheimer's, Amyotrophic lateral sclerosis, and depression were underassessed compared to Parkinson's. The literature focused on four separate themes: physiology of voice-affecting conditions; speech acoustics for evaluating dysphonia; speech production measurements for treating voice disorders; machine learning integration for voice disorder assessment.
    CONCLUSIONS: Taking a wide view of acoustic voice assessment demonstrated research strengths and gaps-highlighting where it is used and not used-and the co-occurrence of various voice assessment topics. These insights reveal future opportunities to implement acoustic voice assessment.
    Keywords:  Acoustics; Bibliometrics; Digital health; Literature review; Speech acoustics; Voice assessment; Voice disorders
    DOI:  https://doi.org/10.1016/j.jcomdis.2025.106555
  27. Front Oral Health. 2025 ;6 1533159
    Research status and hotspots of oral frailty in older adults: a bibliometric analysis from 2013 to 2024.
    Jiaojiao Wu, Doudou Lin, Weibing Chen, Lili Zhang, Xiangying Shen, Dou Fu, Yinglin Li, Xiaojie Ma, Zhongxiang Cai.
       Background: Oral frailty has emerged as a critical focus in public health due to its strong association with adverse health outcomes in older adults, such as cognitive decline, malnutrition, falls, disability, and mortality. Despite a growing body of research over the past decade, a comprehensive bibliometric analysis of this field remains lacking. This study addresses this gap by providing an overview of the research landscape, highlighting key achievements, identifying emerging trends, and proposing directions for future exploration.
    Methods: A bibliometric analysis was conducted on literature related to oral frailty in older adults published between 2013 and 2024, utilizing the Web of Science Core Collection (SCIE and SSCI). The analysis employed CiteSpace, VOSviewer, and the "bibliometrix" R package to visualize and evaluate contributions from countries/regions, organizations, authors, journals and articles. Additionally, references and keyword analyses were performed to identify research patterns and thematic trends.
    Results: The bibliometric analysis of 847 articles published from 2013 to 2024 revealed that Japanese scholars contributed the most publications in the field (n = 204), representing 24.09% of the total. The cooperation network map revealed the highest intensity of collaboration among researchers from the United Kingdom, the United States and Japan. Watanabe Y and Hirano H, both from Japan, were identified as the most prolific and frequently co-cited authors. The research focuses on the multifactorial mechanisms of oral frailty, comprehensive intervention measures and quality of life. Key research hotspots in the field included tongue pressure, tooth loss, social support, quality of life, health promotion, dental care, and root caries. Emerging research directions may include inflammation, swallowing function and oral function.
    Conclusion: Research on oral frailty in older adults has advanced significantly over the past decade, with Japan making particularly notable contributions to the field. The multifactorial mechanisms of oral frailty, multidimensional evaluation methods, and comprehensive intervention strategies are expected to remain central research focuses. Our findings aim to provide researchers with a clearer understanding of trends within this field.
    Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD42024570590, PROSPERO CRD42024570590.
    Keywords:  bibliometric; older adults; oral frailty; research hotspots; research trends; visual analytics
    DOI:  https://doi.org/10.3389/froh.2025.1533159
  28. Front Sports Act Living. 2025 ;7 1590858
    Research patterns in sports law and sports governance: a scopus bibliometric study.
    Marina Kamenecka-Usova, Zanete Korde, Janis Zidens, Signe Luika, Olena Agapova, Karina Palkova, Kristine Martinsone.
      This bibliometric study explores research patterns in lex sportiva, sports law and sports governance, analyzing data retrieved from Scopus between 1977 and 2024. The study examines publication trends, citation networks, keyword co-occurrence and the most influential sources to identify key themes, leading authors and reputable journals. The results indicate that while both fields have been extensively studied, their intersection remains relatively underexplored, with "good governance" emerging as the primary link between sports law, lex sportiva, and governance studies. The citation analysis highlights regional disparities, with Australia, the United States, and the United Kingdom leading in research impact, while countries such as China and Germany exhibit high output but lower citation influence. Co-authorship networks reveal strong collaborations within Europe and North America but limited engagement from other regions. The findings underscore the growing importance of sports governance and legal frameworks in addressing contemporary challenges, particularly within the European Sport Model. This study provides valuable insights for researchers and policymakers, emphasizing the need for interdisciplinary approaches to further advance the field.
    Keywords:  bibliometric analysis; good governance; lex sportiva; sports governance; sports law
    DOI:  https://doi.org/10.3389/fspor.2025.1590858
  29. J Evid Based Soc Work (2019). 2025 Jul 31. 1-22
    Bibliometric Analysis of Social Work Studies Published in WoS from Turkey.
    Hüseyin Zahid Kara, İhsan Kutlu.
       PURPOSE: This study aims to conduct a bibliometric analysis of publications affiliated with Turkey in the Social Work category of the Web of Science (WoS) database. The analysis focuses on thematic trends, publication dynamics and collaboration networks over the last four decades.
    MATERIALS AND METHODS: Data were retrieved from the WoS Core Collection on 26 December 2024. Search was conducted using the "Social Work" category filter, with country affiliation limited to Turkey. Only articles and review papers were included. A total of 504 publications by 1,372 authors were analyzed using MS Excel, VOSviewer and Bibliometrix. Following bibliometric indicators were examined: publication year, journal distribution, keyword frequency, author collaboration.
    RESULTS: There has been a marked increase in publication output since 2019. The most frequently used publication outlets were "Children and Youth Services Review," "Journal of Social Service Research" and "Social Work in Public Health Journal." Frequently used keywords included "health," "mental health," "depression," and "adolescents." Institutional and international collaboration patterns revealed that the most active partnerships were with the United States, the United Kingdom, and Germany.
    DISCUSSION: The findings suggest a growing thematic focus on mental health, child welfare, and psychosocial issues, particularly during and after the pandemic. While methodological themes remain underrepresented, international collaboration and thematic diversity have increased.
    CONCLUSION: Turkey-affiliated social work research is increasingly being integrated into global scholarship. There has been notable progress in thematic scope and international collaboration. However, methodological diversification remains a key area for future development.
    Keywords:  Turkey; bibliometric analysis; social work; web of science
    DOI:  https://doi.org/10.1080/26408066.2025.2541632
  30. Front Neurol. 2025 ;16 1525481
    Trends in Mendelian randomization in neurological disease research: a bibliometric analysis.
    Shengnan Yin, Kudelati Zakeer, Zekun Ma, Miaomiao Zhao, Aierpati Maimaiti, Zengliang Wang.
      Bibliometric analysis (BA) was used in this study to examine the current state and trends of Mendelian randomization (MR) in neurological disease research. The Web of Science database was searched between 1 January 2014 and 1 September 2024 to retrieve relevant literature. The volume of publications, research themes, collaborative networks, and geographical distribution were studied quantitatively. A keyword co-occurrence analysis identified prominent research hotspots, including stroke, cardiovascular disease, and genome-wide association studies. Furthermore, highly cited literature underscored the potential of MR to elucidate causal relationships between genetic variants and health outcomes. International collaborative networks indicate that China, the United Kingdom, and the United States are the most engaged in collaborative efforts within this domain. The findings suggest that MR methods hold significant potential for applications in the investigation of neurological disorders, highlighting the necessity of international collaboration to foster scientific advancement. Future research should prioritize enhancing interdisciplinary collaboration and conducting comprehensive explorations of disease mechanisms to aid in prevention and treatment.
    Keywords:  Mendelian randomization; bibliometric analysis; neurological disease; research trends; review
    DOI:  https://doi.org/10.3389/fneur.2025.1525481
  31. J Cardiothorac Surg. 2025 Jul 28. 20(1): 316
    Trends and advances in cardiac rehabilitation for congenital heart disease: a bibliometric analysis.
    Haojie Zhou, Yuyang Huang, Weizhi Zhang, Hanyi Yao, Zhangqing Yi, Dongping Li.
       BACKGROUND: Congenital heart disease (CHD) survivors often suffer from impaired health-related quality of life (HRQoL), requiring cardiac rehabilitation (CR) as an additional intervention. CR involves various modalities and has been demonstrated to reduce mortality and improve HRQoL in cardiovascular diseases. However, there is a lack of systematic analysis and summary of the accumulated literature on cardiac rehabilitation for congenital heart disease (CRfCHD). This study aimed to provide a comprehensive overview of the literature on cardiac rehabilitation for congenital heart disease. By analyzing research trends and hotspots, it also sought to highlight key developments and suggest future directions in this growing field.
    METHODS: A systematic search of the Web of Science Core Collection was performed to identify publications related to CRfCHD. Bibliometric tools, including CiteSpace and VOSviewer, were used to visualize co-authorship networks, keyword clusters, and citation patterns.
    RESULTS: A total of 218 articles were included in the analysis. The number of research papers on CRfCHD has shown an increasing trend over time, with a significant rise in publications since 2019. The United States has the highest number of publications, while the most cited paper focuses on the effects of physical exercise training in CHD patients. Keyword analysis reveals hotspots in the field such as congenital heart disease, physical activity, children, and adolescents.
    CONCLUSION: This bibliometric study analyzed the development of CRfCHD from 2003 to 2022, and overviewed the evolution and frontiers in this promising field. Future research should focus on developing comprehensive and effective CRfCHD programs. Home-based cardiac rehabilitation and mental health research in CHD patients require more attention.
    Keywords:  Bibliometrics; Cardiac rehabilitation; Family practice; Mental health; Physical activity; Quality of life
    DOI:  https://doi.org/10.1186/s13019-025-03562-z
  32. Quant Imaging Med Surg. 2025 Jul 01. 15(7): 6340-6359
    Application of non-invasive imaging in myocardial infarction: a bibliometric analysis from January 2003 to December 2022.
    Pei Yang, Xinwen Wu, Yaya Zhao, Qingyou Ye, Mengyao Hu, Yinping Leng, Xuan Xiao, Jiahui Zhang, Haibo Ren, Lianggeng Gong.
       Background: Myocardial infarction (MI) is a leading cause of death and disability worldwide. Non-invasive cardiac imaging has garnered significant attention in both MI diagnostic and prognostic research. Despite the growing body of published articles, no comprehensive, quantitative analysis has been conducted to delineate key trends and emerging areas in the field of non-invasive imaging for MI. This bibliometric analysis aimed to systematically evaluate the landscape of non-invasive cardiac imaging-focused research on MI in terms of the research status, publication patterns, influential contributors, hotspots, and focal development trends.
    Methods: We systematically searched the Web of Science Core Collection (WoSCC) to retrieve publications related to MI imaging between 2003 and 2022. Only "articles" and "reviews" written in English were included in the final analysis. Subsequently, a manual screening process was employed to eliminate articles not relevant to the topic. The search results were exported as a plain text file in "Full Record and Cited References" format, and stored as "download_*.txt". CiteSpace and VOSviewer software were used to conduct the bibliometric and visualization analyses. These tools allowed us to analyze countries/regions and institutions' contributions, the top journals, prolific authors, influential references, and keywords.
    Results: Our bibliometric analysis included 33,480 publications from 138 countries, involving contributions from 19,554 institutions and 146,043 authors. Annual publications in this field have shown a rapid increase since approximately 2004. The United States of America (USA) leads in MI imaging research, boasting the highest number of publications (n=11,431), prolific research institutions, and numerous core authors. Notably, Harvard University and the University of California System emerged as the primary research institutions. Among the authors, Budoff was the most prolific contributor (n=209). The co-citation analysis, which measures how frequently an author's work is cited together with other key studies in the field, showed that Kim (n=2,794) was the most influential author based on co-citations, highlighting his significant influence in the area. Most articles appeared in the journal of the American College of Cardiology, while Circulation was the most frequently co-cited journal. Key topics included MI, risk-factor, magnetic resonance imaging (MRI), and atherosclerosis. Recent popular keywords such as ST-elevation myocardial infarction (STEMI), coronary computed tomography angiography (CTA), guidelines, and recommendations indicated future research directions.
    Conclusions: Our bibliometric analysis revealed that MI non-invasive imaging is a rapidly developing field, with emerging trends in multimodal imaging and artificial intelligence (AI). These findings suggest that the integration of various imaging techniques and the use of AI could enhance the clinical application of MI non-invasive imaging, particularly in terms of early diagnosis, risk stratification, and personalized treatment strategies.
    Keywords:  CiteSpace; Myocardial infarction (MI); bibliometric; non-invasive cardiac imaging
    DOI:  https://doi.org/10.21037/qims-24-878
  33. Int J Phytoremediation. 2025 Jul 30. 1-9
    Recent trend in phytoremediation of petroleum hydrocarbon contaminated soil: a bibliometric review.
    Kwang Mo Yang.
      Phytoremediation is an environmentally friendly and low-cost technology for remediating petroleum contaminated soils. This review analyzed the publications indexed in the Scopus database between 2015 and 2025. The number of publications and citations related to the phytoremediation of petroleum hydrocarbons has increased rapidly, presumably due to the growing environmental pollution of petrochemicals worldwide. China emerged as the most productive country, followed by India and the United States, respectively. The majority of publications were found in Environmental Science and Pollution Research, International Journal of Phytoremediation, Chemosphere, Science of the Total Environment, and Journal of Hazardous Materials. The top five keywords in this field were bioremediation, polycyclic aromatic hydrocarbons, petroleum hydrocarbons, rhizoremediation, and heavy metals, excluding phytoremediation. The keyword analysis showed a focus on co-contaminated soil, plant-microbial interaction, amendment-assisted phytoremediation, and phytotoxicity. This bibliometric review provides valuable insights for future directions related to the phytoremediation of petroleum hydrocarbons.
    Keywords:  Bibliometric; petroleum hydrocarbons; phytoremediation; research trends
    DOI:  https://doi.org/10.1080/15226514.2025.2539429
  34. Nurse Educ Pract. 2025 Jul 28. pii: S1471-5953(25)00247-1. [Epub ahead of print]87 104490
    Integrating knowledge on diversity in nursing education: A bibliometric review of thematic trends and trajectories.
    Neta Roitenberg.
       AIM: This study aims to analyze the thematic advances and trajectory of diversity in nursing education through bibliometric analysis.
    BACKGROUND: The growing emphasis on diversity in nursing education underscores its increasing importance and impact on nursing practice and healthcare outcomes. However, a key gap remains, as diversity in nursing education has largely been studied in a manner that lacks integration of the various topics composing the scholarly knowledge and lacks cohesive thematic development or exploration of this knowledge base. Consequently, a comprehensive bibliometric review that provides an integrated overview of this critical area, highlighting its thematic evolution and historical development, is still needed.
    DESIGN: Bibliometric analytic methods.
    METHODS: The data were analyzed, and the graphic representation was made using the Bibliometrix Package of R software. A search of the Web of Science Core Collection was conducted on April 29, 2025. Descriptive analysis, citation analysis, co-word analysis, cooperation analysis and theme map analysis were among the techniques employed.
    RESULTS: From 658 articles, 1521 author keywords were identified. Publications have increased over three decades at an annual rate of 10.64 %. Core themes forming the foundation of the field include nursing education and nursing education diversity. Key research drivers are represented by themes such as COVID-19, nursing diversity, cultural safety and health workforce.
    CONCLUSIONS: This bibliometric study highlights the growing recognition of diversity's importance in nursing education. Findings show a global rise in research, reflecting increased commitment to addressing diversity-related challenges.
    Keywords:  Bibliometrics; Diversity; Nurses; Nursing education; Nursing students
    DOI:  https://doi.org/10.1016/j.nepr.2025.104490
  35. Discov Oncol. 2025 Jul 25. 16(1): 1406
    Targeted therapy for Wilms tumor: a bibliometric study of worldwide scientific activity and collaborative networks.
    Boshen Shu, Shufeng Zhang, Jian Gao, Lin Wang, Xiaohui Wang.
       BACKGROUND AND PURPOSE: Wilms tumor (WT), or nephroblastoma, is the most common abdominal solid tumor in children with a recurrence rate as high as 15%. Targeted therapy is an effective treatment choice for patients with WT. This study aimed to evaluate the global research activity and collaborative networks of WT targeted therapy through the bibliometric analysis.
    METHODS: The Web of Science Core Collection (WoSCC) database was used to search related studies on targeted therapy for WT published between 1945 and 2024. Subsequently, the VOSviewer, Graphpad, and Bibliometrix package in the R Studio were applied to conduct bibliometric and visualized analysis.
    RESULTS: A total of 1,604 publications were included in our analysis. The USA (n = 572) took the dominant position in the number of publications and Harvard University contributed most papers (n = 122). Sugiyama H and Oka Y demonstrated superior performance in this domain, with Sugiyama H leading in the number of publications (n = 59) and Oka Y leading in terms of co-citations (n = 382). The most productive journal was the Oncogene (n = 44). "Expression" and "Wilms Tumor" were the most frequent keywords, while "lncRNA", "Biomarkers" and "microRNA" were recent hotspots.
    CONCLUSIONS: Research on targeted therapy for WT has developed rapidly with increasing interests, which emphasizes its growing importance in the scientific community. Nonetheless, the primary research has been primarily concentrated in a limited number of developed regions, and global collaboration remains inadequate. International collaborations and translational research should be reinforced to facilitate further advancements in this field.
    Keywords:  Bibliometrics; Global collaboration; Nephroblastoma; VOSviewer; Visualized analysis; Wilms tumor
    DOI:  https://doi.org/10.1007/s12672-025-03255-y
  36. J Multidiscip Healthc. 2025 ;18 4145-4157
    Research Trends and Knowledge Mapping of Opioid-Free Anesthesia: A Global Bibliometric Analysis.
    Zhiwei Guo, Zhonggui Shan, Feifei Wang.
       Purpose: Opioid-free anesthesia (OFA), as a potential anesthetic strategy, can provide better clinical outcomes for surgical patients while avoiding opioid-related adverse side effects. However, the current knowledge framework and research progress in OFA have not yet been systematically reviewed or comprehensively analyzed. This study aims to employ bibliometric methods to thoroughly explore research trends, hotspots, and developmental directions in this field.
    Methods: This study retrieved opioid-free anesthesia-related literature published between 1980 and 2024 from the Web of Science Core Collection database. Through systematic analysis of publications, countries, institutions, authors, journals, references, and keywords, combined with bibliometric visualization using software such as Citespace, VOSviewer, and Bibliometrix, this study comprehensively reveals the research status and developmental trends in this field.
    Results: OFA research demonstrates a significant growth trend, with a sharp increase in publications over the past decade, reaching 2,219 citations in 2024 alone. The United States leads globally with 291 publications (7,896 citations) yet exhibits low international collaboration network density (0.008). Research hotspots evolve into three phases: early-stage focus on basic anesthetic protocols, mid-stage shift toward perioperative management optimization, and recent emphasis on clinical outcome improvement. Keyword analysis identified four core themes: anesthetic agents and protocols, perioperative management, and analgesic strategy optimization.
    Conclusion: OFA research is in a phase of rapid development but requires enhanced international collaboration and clinical translation. Future efforts should focus on developing personalized OFA protocols, investigating long-term outcomes, and establishing multicenter research networks to provide higher-quality evidence for clinical practice.
    Keywords:  bibliometrics; opioid; opioid-free anesthesia; pain
    DOI:  https://doi.org/10.2147/JMDH.S533687
  37. Leg Med (Tokyo). 2025 Jul 25. pii: S1344-6223(25)00111-7. [Epub ahead of print]77 102677
    Forensic wound age estimation (2003-2024): evolving perspectives on tissue viability and molecular pathology.
    Di Jin, Lushun Zhang.
      Determining the precise timing of injuries remains a longstanding and complex challenge in forensic pathology. Within the domain of injury time extrapolation, our research emphasizes the use of immunohistochemical techniques to detect wound viability markers, offering a promising approach to infer the temporal dynamics of tissue injury. Despite growing interest in this area, comprehensive bibliometric analyses remain scarce. This study aims to evaluate the current landscape and emerging trends in forensic injury time extrapolation through a systematic bibliometric approach. Relevant literature was retrieved from the Web of Science Core Collection (WOSCC), covering the period from January 2003 to August 2024. A total of 992 publications were analyzed using a suite of bibliometric tools, including VOSviewer, CiteSpace, Pajek, and Scimago Graphica. Quantitative indicators, such as publication output, country and institutional contributions, key authors and journals, keyword frequencies, and citation patterns, were examined to map the structural and thematic development of the field. The results revealed that China and the United States are the leading contributors to this area of research, with the Chinese Academy of Sciences identified as the most productive institution (n = 19). The International Journal of Legal Medicine emerged as the most prolific journal (n = 33), while Analytical Chemistry held the highest citation count (n = 155, impact factor = 6.7). Keyword co-occurrence analysis highlighted "system" (n = 43), "model" (n = 40), and "expression" (n = 36) as dominant thematic elements. Notably, recent years have seen a marked increase in studies focusing on immunohistochemistry and wound viability markers. Collectively, the findings underscore the growing importance of forensic injury time extrapolation as a research frontier. The prominence of viability markers and immunohistochemical methods suggests a shift toward molecular and cellular-level investigations, holding significant potential for enhancing the precision of forensic timing techniques in future studies.
    Keywords:  Bibliometrics; CiteSpace; Forensic medicine; Time of injury estimation; VOSviewer
    DOI:  https://doi.org/10.1016/j.legalmed.2025.102677
  38. J Chin Med Assoc. 2025 Jul 30.
    Bibliographic analysis of Taiwanese publications in the Web of Science Respiratory System Category from 1972 to 2023.
    Ying-Hsuan Hwang, Chih-Teng Chiang, Yuh-Min Chen, I-Hsuan Hwang, Chun-Feng Huang, Yu-Chun Chen, Shinn-Jang Hwang.
       BACKGROUND: Academic publications are important for developing medical specialties. Respiratory system diseases are among the most common human diseases and have significant impacts on morbidity and mortality. This is particularly true regarding the impact of the new coronavirus, severe acute respiratory syndrome coronavirus 2. This study aimed to perform a bibliographic analysis of Taiwanese academic publications in the Web of Science (WoS) subject category of respiratory systems.
    METHODS: Publications in the WoS Respiratory System Category, including papers in Science Citation Index Expanded and Social Sciences Citation Index journals from 1972 to 2023, were retrieved and analyzed.
    RESULTS: Among 392,030 papers published worldwide in the WoS Respiratory System Category from 1972 to 2023, 3,672 (0.94%) were published in Taiwan, ranking 21st in the world, with a total of 82,956 citations. Over these five decades, the annual number of Taiwanese publications and citations has increased over time. However, the mean impact factor of publications has shown a tendency to decrease since 1997. International collaboration with coauthors outside Taiwan was found in 780 papers (21.24% of the total publications), mainly from the United States, the People's Republic of China, the United Kingdom, France, and South Korea. Collaborative papers had a significantly higher mean impact factor (8.2 ± 0.3 vs. 5.6 ± 0.1, p< 0.001) and citation counts per paper (44.2 ± 3.3 VS. 25.2 ± 0.8, p< 0.001) than those of non-collaborative papers.
    CONCLUSION: Taiwanese publications in the WoS Respiratory System Category have a trend of increasing number and citations since 1972. However, the mean impact factor of the published papers has decreased since 1997. This disproportionate trend is an observational finding that deserves further investigation.
    Keywords:  Bibliography; Citations; Impact factor; Respiratory system; Web of Science
    DOI:  https://doi.org/10.1097/JCMA.0000000000001275
  39. Cureus. 2025 Jun;17(6): e86947
    Assessment of Productivity and Quality of Publications Derived From Doctoral Theses and the Scientific Performance of Graduates at a Romanian Medical and Pharmacy University.
    Andreea I Pop, Mira Florea, Simona Mirel, Lucia M Lotrean.
      Objectives This study focuses on assessing the productivity and quality of publications resulting from doctoral research as well as the scientific performance of individual researchers at the University of Medicine and Pharmacy in Cluj-Napoca, Romania. It analyzes scientific publication rates before, during, and after doctoral school. We analyzed the bibliometric indicators of publications indexed in the Web of Science database, which are derived from doctoral research and feature graduates as first authors, as well as the factors that might impact the research outcomes. Design and setting This investigation is a longitudinal observational study conducted from January to March 2023 at Iuliu Hatieganu University of Medicine and Pharmacy in Cluj-Napoca, Romania. The study employed both descriptive and analytical research methods. The sample comprises public information about 169 doctoral (PhD) candidates who successfully completed the doctoral program between 2019 and 2021. We collected data from various public databases, including the university's website, the university library, and the Web of Science Core Collections. Main outcome measures and research productivity The primary outcome measures include gender, graduation years, qualification, teaching position, doctorate final grade, and Hirsch index (H-index). The productivity of research includes the total number of WoS-indexed publications, conference proceedings, and manuscripts in various databases. Research quality and visibility are represented by total citations, journal impact factors and journal rankings. Factors influencing research dissemination: The factors that influence research dissemination include the number of co-authors, financial support, and interdisciplinary/international collaborations. The publication timeline includes research output before, during, and after graduation. Results At the University of Medicine and Pharmacy Iuliu Hatieganu, doctoral theses produced high-quality research; 332 (91%) of the publications were indexed in WoS journals with JIF, 136 (38%) of these publications were in top-ranked journals, and 298 (81%) of the publications received citations. Before they graduated, graduates also published the findings of other studies, and some of them continued publishing after graduation. The graduation qualification strongly correlated with the graduates' publications' productivity, impact, and visibility. The study found that financial support and international collaboration had a positive influence on the publication's visibility and quantity. Conclusions This study provides new quantitative and qualitative evidence that can enhance discussions regarding the assessment of academic performance and the mentoring of doctoral students. Our study identifies various factors that can influence the results of research.
    Keywords:  doctoral student; medical education and research; publication rate; scientific publication indicators; thesis
    DOI:  https://doi.org/10.7759/cureus.86947
  40. Neurochirurgie. 2025 Jul 29. pii: S0028-3770(25)00077-3. [Epub ahead of print]71(5): 101704
    Trends and development of enhanced recovery after surgery programs in cranial and spinal neurosurgery.
    Shichao Liu, Jingyu Zhou.
       BACKGROUND: Enhanced Recovery After Surgery (ERAS) has garnered considerable attention and demonstrated substantial clinical benefits across multiple surgical specialties. However, its integration into cranial and spinal neurosurgery remains nascent and fraught with challenges. This study aims to systematically assess the current research landscape, identify emerging hotspots, and forecast future directions for ERAS in neurosurgery through comprehensive bibliometric analysis. These findings seek to inform clinical practice and guide future investigations.
    METHODS: Relevant publications indexed in the Web of Science Core Collection from January 1, 1999, to December 1, 2024, were analyzed. Bibliometric tools, primarily CiteSpace, were utilized to evaluate annual publication trends, author and institutional contributions, journal dissemination, keyword co-occurrence, and citation network structures.
    RESULTS: A total of 273 articles were included. The analysis reveals that ERAS implementation in spinal neurosurgery has reached a relatively advanced stage, while its application in cranial procedures remains underdeveloped, yet promising. The United States and China are leading in publication output, although China's global influence is comparatively limited. Key research themes include hospital length of stay, cost-effectiveness, postoperative complication management, and multimodal analgesia. Anticipated trends suggest a growing focus on personalized ERAS protocols tailored to specific neurosurgical conditions and enhanced patient engagement in recovery processes.
    CONCLUSION: Through bibliometric and visualization techniques, this study offers a comprehensive overview of ERAS-related neurosurgical research, delineating its evolution and thematic shifts. The insights derived herein may facilitate strategic planning, foster interdisciplinary collaboration, and promote evidence-based advancements in perioperative neurosurgical care.
    Keywords:  Bibliometrics; CiteSpace; Enhanced recovery after surgery; Neurosurgery; Research trends
    DOI:  https://doi.org/10.1016/j.neuchi.2025.101704
  41. Front Med (Lausanne). 2025 ;12 1537446
    Advancements and trends in digestive system autotransplantation: a bibliometric and visualization analysis.
    Aimitaji Abulaiti, Talaiti Tuergan, Alimu Tulahong, Ruiqing Zhang, Yingmei Shao, Tuerganaili Aji.
       Background: Digestive system autotransplantation is an emerging surgical technique used to treat complex digestive diseases.
    Methods: This study conducted a bibliometric analysis of 748 publications from the Web of Science Core Collection (WoSCC) database, using VOSviewer and CiteSpace tools to map research trends, author contributions, and institutional collaborations. Articles were selected based on their relevance to digestive system autotransplantation, focusing on autologous liver, pancreatic, and small intestine transplantation. The analysis included publication volume, citation counts, key authors, leading journals, and keyword co-occurrence.
    Results: The analysis revealed a steady rise in publications between 2004 and 2015, followed by a gradual decline after 2016. The United States leads in research output, accounting for 40.11% of publications, followed by China. The leading institutions are predominantly based in the United States, with the University of Minnesota System producing the most publications. High-frequency keywords include autologous transplantation, pancreatic transplantation, chronic pancreatitis (CP), and postoperative complications.
    Conclusion: Digestive system autotransplantation is a promising approach for complex cases. Continued interdisciplinary collaboration and focus on clinical outcomes will drive future advancements.
    Keywords:  autologous transplantation; bibliometric analysis; chronic pancreatitis; digestive system autotransplantation; pancreatic transplantation
    DOI:  https://doi.org/10.3389/fmed.2025.1537446
  42. J Multidiscip Healthc. 2025 ;18 4197-4217
    Worldwide Research Trends on the Immunotherapy-Based Treatment of Ovarian Cancers: A Bibliometric and Visual Analysis.
    Lu Yan, Yibin Liu, Zhiqiang Zhang, Feida Du.
       Purpose: Immunotherapy-based treatment has shown significant clinical potential in various cancers. This study provides a comprehensive bibliometric analysis of the immunotherapy landscape in ovarian cancer over the last decade, identifying leading trends, influential contributors, and key areas of development.
    Methods: A systematic literature search was conducted in the Web of Science Core Collection for publications on immunotherapy drugs used in ovarian cancer between 2014 and 2024. Analytical tools such as VOSviewer, CiteSpace, and the R-based Bibliometrix package were employed to visualize trends, collaborations, and major contributions.
    Results: Our dataset of 2123 publications from 2014 to 2024 highlights a rise and stabilization in publication output, peaking in 2022. Leading journals included Cancers and Frontiers in Oncology. Although a recent decline was observed, it may reflect a shift toward refining existing therapies rather than initiating new studies. The United States and China were major contributors, with institutions such as Harvard University, University of California, and Fudan University leading in output. European institutions like Charité Berlin and KU Leuven also played prominent roles, with key researchers including Sehouli J, Vergote I, and Scambia G. Highly cited studies included The Cancer Genome Atlas, which identified critical genetic mutations in high-grade serous ovarian cancer, and landmark trials exploring the addition of bevacizumab to standard therapies. These works emphasize ongoing challenges such as genetic heterogeneity and resistance, driving research toward biomarker-based and personalized therapeutic strategies. Thematic clustering revealed a progression from foundational treatment trials to precision medicine, with focus areas including platinum resistance and neoadjuvant therapies.
    Conclusion: This bibliometric analysis maps the growing research interest in immunotherapy-based approaches for ovarian cancer, highlighting the field's collaborative and multidisciplinary nature. The findings provide a foundation for identifying influential themes and guiding future investigations into resistance mechanisms and personalized treatment strategies.
    Keywords:  bibliometric analysis; immunotherapy; network analysis; ovarian cancer; publication trends
    DOI:  https://doi.org/10.2147/JMDH.S526280
  43. Discov Oncol. 2025 Jul 30. 16(1): 1441
    Androgen receptor as a potential therapeutic target in castration-resistant prostate cancer: a bibliometric analysis (2005-2024).
    Jiexiang Zhang, Weichen Yuan, Tongtong Zhang, Xuesong Liu, Dongliang Xu.
       INTRODUCTION: The androgen receptor (AR) remains a focal target in castration-resistant prostate cancer (CRPC) research, with recent studies providing valuable insights for advancing AR-targeted therapies. This study employs bibliometric methods to comprehensively analyze research trends in the CRPC and AR fields, identifying emerging hotspots and future directions.
    METHODS: Publications from 2005 to 2024 were extracted from the Web of Science Core Collection (WoSCC). Bibliometric analysis and data visualization were performed using VOSviewer, CiteSpace, and the R package "Bibliometrix."
    RESULTS: A total of 3,149 publications authored by 15,704 researchers across 75 countries were analyzed. Publication output exhibited rapid growth over the past two decades. The United States dominated contributions, with the University of Washington ranking as the leading institution. Antonarakis, Emmanuel S. was the most prolific author, while Scher, Howard I. emerged as the most cited researcher. PROSTATE published the highest number of studies, whereas CANCER RESEARCH was the most cited journal. References co-citation analysis and keyword burst revealed persistent research emphasis on AR splice variants and CRPC drug resistance, with emerging investigations into novel membrane antigens representing current frontiers.
    CONCLUSION: This study delineates the evolving knowledge framework and shifting priorities in CRPC and AR research, offering strategic insights to guide future AR-targeted therapeutic development for CRPC.
    Keywords:  Androgen receptor; Bibliometrics; Castration-resistant prostate cancer; Web of science
    DOI:  https://doi.org/10.1007/s12672-025-03304-6
  44. J Glob Infect Dis. 2025 Apr-Jun;17(2):17(2): 98-103
    Impact, Trends, and Visibility of Scientific Publications on Neurological Effects of COVID-19 Vaccine: A Scientometric Analysis.
    Ana Paula Sangama Ramírez, Raúl Sebastián Tello Cavero, Frank Mayta-Tovalino.
       Introduction: Neurological complications associated with the COVID-19 vaccine can include different neurological diseases. Although these cases are rare, it is crucial for healthcare professionals to recognize them for timely diagnosis and treatment. The aim of this study was to analyze the impact, trend, and visibility of scientific publications on the neurological effects of the COVID-19 vaccine during 2020-2023 in Scopus.
    Methods: A bibliometric, descriptive, and retrospective study was conducted. Through Scopus (SciVal), variables were measured objectively. Data were sought from December 2018 to August 2023. All papers on neurological effects associated with the COVID-19 vaccine were published between January 2020 and August 2023 in the Scopus database. On August 18, 2023, 65 articles were identified, of which 59 met the inclusion criteria. They were downloaded and exported in.csv format and subsequently analyzed in Microsoft Excel® 2019 using tables.
    Results: The United States was the country with the highest number of authors (six) publishing on the subject in Scopus, followed by India with two authors. In addition, it was observed that the United States was the country with the highest production, with 30 publications and 411 countable citations. However, India, being the second in scientific production, was the country with the highest impact. Of the most productive institutions, six were from the United States, with Harvard University being the institution with the highest scientific production. With respect to the journals, six obtained two publications on the subject under study, where "Journal of Neurology" and "Journal of Clinical Medicine" stand out with 100 and 80 publications, respectively.
    Conclusions: The bibliometric analysis reveals that the USA leads in publications on adverse neurological effects of COVID-19 vaccine. India stands out for its impact, especially through institutions such as Ahmedabad Civil Hospital and B. J. Medical College. It is suggested to expand the research to other databases.
    Keywords:  Bibliometrics; COVID-19; neurological manifestations; vaccines
    DOI:  https://doi.org/10.4103/jgid.jgid_159_24
  45. Eur Arch Otorhinolaryngol. 2025 Jul 30.
    A comment on the search strategy in the sulcus vocalis bibliometric analysis.
    Ahmet Ufuk Kilictas.
      
    DOI:  https://doi.org/10.1007/s00405-025-09617-0
  46. Acta Psychol (Amst). 2025 Jul 31. pii: S0001-6918(25)00631-6. [Epub ahead of print]259 105318
    Five decades of teacher burnout research (1970-2024): A comprehensive bibliometric analysis.
    Jie Yao, Melissa Ng Lee Yen Abdullah.
      Over the past five decades, research on teacher burnout has expanded significantly, emphasizing its profound impact on educators' well-being, job performance, retention, and overall educational quality. However, the vast body of literature makes it difficult to synthesize the field's evolution, leading scholars to call for more structured overviews. To address this gap, this study conducts a bibliometric analysis to examine prominent authors, their collaborative networks, international collaboration patterns, thematic influences, and their role in shaping the development and impact of teacher burnout research. Using the Social Sciences Citation Index (SSCI) in Web of Science (WOS), this study analyzes publications on teacher burnout from 1970 to 2024. Findings shows that a significant surge in research began in 2012 (24 publications) and the upward trend continued steadily. The leading authors in teacher burnout research represent a geographically diverse group, yet the lack of strong global collaboration highlights the need for greater international partnerships, which could significantly enhance knowledge-sharing and advance research on a global scale. The findings are based on a bibliometric analysis employing keyword co-occurrence and thematic clustering techniques. The results revealed that existing studies primarily focus on key themes such as stress, self-efficacy, social support and job satisfaction within the literature on teacher occupational burnout, while critical aspects such as classroom environment, emotional intelligence and work-family conflict remain underexplored. These factors play a crucial role in burnout, as classroom conditions, emotional regulation, and work-life balance directly impact teachers' stress levels and well-being. Addressing these gaps through a more comprehensive research approach could lead to targeted and effective interventions that enhance teacher well-being, emphasizing the need for international collaboration and culturally responsive practices across diverse contexts.
    Keywords:  Bibliometric analysis; Effective strategies; Teacher burnout; VOS viewer
    DOI:  https://doi.org/10.1016/j.actpsy.2025.105318
  47. Orthop Rev (Pavia). 2025 ;17 142052
    Tears, Tendons, and Trends: A Bibliometric Analysis on Anterior Cruciate Ligament Research.
    Tristan Hoon, Rishank Chillakuru, Latha Ganti.
      This bibliometric analysis investigates global research trends in anterior cruciate ligament (ACL) injury prevention and treatment by evaluating 4,086 articles indexed in the Web of Science Core Collection from 1985 to June 18, 2025. The top funding agencies of ACL research showed governmental-linked institutions from the United States, the People's Republic of China, and Japan supporting a substantial part of ACL literature. Keyword emphasis on surgical methods was evident in the indexed literature on ACL. Continued research towards improving surgical methods will prevent retear, assist in more efficient recovery, and better long-term outcomes for the patient.
    Keywords:  Anterior cruciate ligament (ACL); bibliometric analysis
    DOI:  https://doi.org/10.52965/001c.142052
  48. Hum Vaccin Immunother. 2025 Dec;21(1): 2536910
    Application of monoclonal antibodies in diabetes: A bibliometric analysis from 2004-2024.
    Rui Wei, Bochao Jia, Shuang Zheng, Xuexue Zhang, Miaoran Wang, Ning Sun, Rui Zhang, Qiuyan Li.
      Monoclonal antibodies (mAbs) have shown significant promise in diabetes treatment through immunobiological mechanisms. To comprehensively understand the current development status and future trends of this research field, this study used bibliometric methods to retrieve literature data from the Web of Science Core Collection database from 2004 to 2024 and conducted a comprehensive analysis using R software and VOSviewer. A total of 900 papers were published by 4,678 authors from 56 countries, with global publication volume and average citation frequency peaking in 2019, after which the field entered a stable development phase. The United States emerged as the leading contributor in terms of total publications, citations, and national collaborations. The journal Diabetes had the highest publication output. Herold KC from Yale University ranked highest in publication count, citation frequency, and Hirsch index. Four key research focuses were identified in T1D: the multifaceted roles of mAbs in clinical trials (a hot mature topic), developing therapeutic targets through animal models (a centralized, declining topic), inducing immune tolerance in transplantation using mAbs (a mature, declining topic), and assessing the safety, risk, and efficacy of mAbs in diabetes treatment (a niche and well-developed topic). Substantial clinical progress has already been achieved with mAbs targeting autoimmune destruction in T1D, while therapeutic strategies for metabolic dysregulation in T2D are primarily in the preclinical stage yet show promising potential. Advancing combination therapies, personalizing treatments, and enhancing mechanistic research will improve the safety and efficacy of mAbs in diabetes management, providing valuable insights for future research in this field.
    Keywords:  Monoclonal antibodies; bibliometric; diabetes; research focus; visualization
    DOI:  https://doi.org/10.1080/21645515.2025.2536910
  49. Front Med (Lausanne). 2025 ;12 1611045
    Global research trends in surgical management of choledochal cysts: a bibliometric analysis from 2000 to 2024.
    Xingjian Liu, Guodong Zhu, Jiayi Zhang, Yulong Mu, Zongxing Qiao, Chuan Wang.
       Introduction: Choledochal cysts (CCs), which are congenital biliary anomalies prevalent in Asia, predominantly affect children and carry the risk of severe complications, including malignancy. Surgical intervention, evolving from open to minimally invasive (laparoscopic/robotic) techniques, remains the cornerstone of management. Despite growing research, no bibliometric analysis has mapped the global trends in CCs surgical studies. The aim of this study was to comprehensively analyze the advances in the surgical treatment of CCs since the 21st century and to predict future research directions.
    Methods: Using the Web of Science Core Collection (2000-2024), we analyzed 1,064 publications on CCs surgery via Bibliometrix and CiteSpace. The search terms included surgical techniques (e.g., "laparoscop*," "Roux-en-Y") and disease terms (e.g., "choledochal cyst*"). The data encompassed authorship, citations, institutions, and keywords.
    Results: Average Annual publications increased by 5.95%, peaking by 2023 (n = 93). China (n = 579) and Japan (n = 398) dominated the research output, yet international collaboration was limited (MCP rate <10%). High-impact studies emphasized long-term malignancy risks after Roux-en-Y anastomosis and laparoscopic superiority over open surgery. Keyword analysis revealed shifting foci: "management" (n = 241) and "children" (n = 204) were predominant, while "robotic surgery" emerged post-2010. Institutions such as Monash University and the Capital Institute of Pediatrics led productivity, with the Journal of Pediatric Surgery being the top publisher.
    Conclusion: Surging research on CCs surgery highlights evolving priorities: bibliometrics reveal a growing focus on long-term outcomes and minimally invasive techniques (laparoscopic/robotic). Enhanced preoperative and postoperative management and novel diagnostic methods are critical. Global collaboration and standardized training remain pivotal for optimizing patient prognosis.
    Keywords:  bibliometric; choledochal cysts; complication; management; surgery
    DOI:  https://doi.org/10.3389/fmed.2025.1611045
  50. Biology (Basel). 2025 Jun 27. pii: 781. [Epub ahead of print]14(7):
    Knowledge Structure and Evolution of Wetland Plant Diversity Research: Visual Exploration Based on CiteSpace.
    Xuanrui Zhang, Shikun Chen, Pengfu Yao, Jiahui Han, Ri Jin.
      Plant diversity, as a critical indicator of wetland ecosystem health and functionality, has garnered extensive research attention. However, systematic and quantitative assessments of research advancements in wetland plant diversity remain inadequate. This study pioneers a global bibliometric analysis of wetland plant diversity research (1986-2025), designed to systematically examine its worldwide patterns, knowledge architecture, and evolutionary trends. Bibliometric analysis was performed using CiteSpace V6.2.R4 (64-bit) software on 482 publications retrieved from the Web of Science Core Collection. Results indicate that the United States, Canada, China, and several European countries have collectively prioritized wetland plant diversity research, forming a close international collaboration network. Research themes initially centered on species composition, community structure, and diversity metrics have expanded to multiple dimensions such as ecosystem functions and services, environmental change impacts, and wetland management and restoration, forming several key research clusters. Keyword time-zone mapping reveals the trajectory of research themes from basic descriptions to applied and environmental relevance, while emergent analyses accurately identify hotspots and frontiers of current research such as ecosystem services, functional diversity, and climate change impacts. These findings contribute to comprehending the overall framework and developmental trajectories in wetland plant diversity research, and provide a reference for identifying potential research gaps and planning future research directions.
    Keywords:  CiteSpace; biodiversity; habitat conservation; vegetation; wetland plant diversity
    DOI:  https://doi.org/10.3390/biology14070781
  51. Front Oncol. 2025 ;15 1537508
    A bibliometric and visual analysis of Jak1 to explore trends and frontiers.
    Cong Yu, Jiamin Cao, Xiaodong Xie, Wenguang Chen, Ensi Hong.
       Background: JAK1, a member of the JAK kinase family, is involved in the signal transduction of multiple cytokine pathways and is crucial in the onset and progression of inflammation and tumours. Consequently, JAK1 has garnered significant attention in recent years.
    Methods: We use bibliometric and visual analysis to evaluate the thematic trends and knowledge structure of TRPV1's research papers on JAK1, sourced from the Web of Science core collection from 2003 to 2024. CiteSpace is used to analyze references and keywords of authors, institutions, countries, and commonly cited, and applies co-current and clustering functions to generate visual knowledge maps.
    Results: A total of 3,686 articles were incorporated. The primary research domain of JAK1 is oncology; the United States leads in publication volume, with the University of Texas holding the most prominent central position. The keyword distribution indicates that the literature on JAK1 from 2003 to 2009 primarily concentrated on mechanistic studies, encompassing gene expression, activation, pathways, and cell apoptosis. From 2008 to 2018, research hotspots predominantly examined the association between JAK1 and various disease atlases. Beginning in 2012 and extending to 2024, the focus shifted towards the research and development of clinical pharmaceuticals, along with their safety and efficacy. Gene expression, signal transduction, atopic dermatitis, and JAK1-selective inhibitors have emerged as prominent research areas in recent years, exhibiting significant potential for development.
    Conclusion: This study presents the contemporary status and prospective trends of JAK1 research over the last two decades. Current research focuses on skin inflammation, rheumatoid arthritis, and tumor-related diseases, while new signaling pathways are constantly being discovered. JAK1 inhibitors are gradually being used in clinical practice and have good development prospects, which will become the main trend of future research.
    Keywords:  bibliometric; citespace; jak1; research hotspots; visual analysis
    DOI:  https://doi.org/10.3389/fonc.2025.1537508
  52. Discov Oncol. 2025 Jul 28. 16(1): 1432
    A bibliometric analysis reveals a dynamic growth in the use of artificial intelligence in oral cancer research over three decades.
    Irna Sufiawati, Anisa Insyafiana, Rifat Rahman, Adi Idris.
      Oral cancer (OC) remains a significant malignant neoplasm in both the developed and developing world. Artificial intelligence (AI) has had a significant impact on scientific disciplines, including oncology by transforming data analysis and predictive capabilities. Recent advancements in AI have enabled researchers to integrate and synthesize multidimensional datasets, infer patterns, and predict outcomes, ultimately enhancing shared decision-making between patients and clinicians. This bibliometric analysis aims to provide a comprehensive overview of the application of AI in OC research over the last three decades. Our analysis of 351 articles retrieved from SCOPUS between 1998 and 2024 using VOSviewer highlights the dynamic growth of AI in OC research. The significant trends in publications and citations reflect the increasing interest and impact of this field. These findings provide valuable insights for policymakers, funding agencies, and researchers, guiding future efforts to integrate AI technologies into oral oncology practices.
    Keywords:  Artificial intelligence; Bibliometric analysis; Oral cancer; Research trends; VOSviewer
    DOI:  https://doi.org/10.1007/s12672-025-03293-6
  53. Orthopadie (Heidelb). 2025 Jul 31.
    Evolution of journal rankings in orthopedics and sports medicine (2000-2024) : A SCImago-based bibliometric analysis.
    Raju Vaishya, Sudhir Shekhawat, Abhishek Vaish, Filippo Migliorini.
       BACKGROUND: Academic journals are fundamental to scientific communication, facilitating the dissemination of research findings that spur innovation across clinical and scientific fields. Journal rankings provide valuable insights into the influence and credibility of scholarly outlets.
    OBJECTIVE: This study analyzes the evolution of journal rankings in orthopedics and sports medicine (OSM) from 2000 to 2024, using SCImago Journal Rank (SJR) data to uncover trends in journal prestige and regional representation.
    MATERIAL AND METHODS: A comprehensive bibliometric analysis was performed using SCImago data, comparing journal rankings over 25 years. Key metrics included SJR values and citation counts across orthopedic and sports medicine journals. Statistical significance was assessed using an Independent samples Kruskal-Wallis test.
    RESULTS: The analysis revealed a significant average increase of 36.6% in the SJR of leading OSM journals over the study period. Notably, only 12% of the top ranking journals originated from non-western regions, indicating a geographic bias. Sports medicine-focused journals showed a higher average SJR of 1.75, compared to 1.40 for orthopedic journals (p < 0.05). A global median of 28.7% of female authors was found, reflecting ongoing gender disparities in authorship within OSM.
    CONCLUSION: The findings highlight marked shifts in journal prestige in the OSM field over 25 years, alongside persistent regional biases that may disadvantage high-quality research from non-western regions. The study underlines the importance of awareness regarding these dynamics for stakeholders in making decisions related to publication strategies and funding. Future research should further explore the impact of emerging subfields and the role of open-access publishing in shaping journal rankings in OSM.
    Keywords:  Academic publishing; Bibliometrics; Citation analysis; Impact factor; Research trends
    DOI:  https://doi.org/10.1007/s00132-025-04683-y
  54. Int J Surg. 2025 Jul 15.
    Advance in the use of Artificial Intelligence of Pulmonary nodule: evolution, trends, and future directions.
    Xue Li, Wenzheng Zhang, Jiliang Fang, Chunzhi Li, Hongsheng Lin, Yun Xu, Yufei Yang, Xueqian Wang.
       BACKGROUND: Timely detection and intervention for pulmonary nodules play a vital role in decreasing lung cancer-related deaths. Nevertheless, the precise differentiation between benign and malignant nodules continues to face a major clinical challenge. With the rapid progress of artificial intelligence (AI), significant improvements have been made in the detection, classification, and clinical decision-making related to pulmonary nodules. Although scholarly interest in this domain has surged in recent years, there is still a lack of comprehensive bibliometric studies that systematically map its current landscape and evolution. This study seeks to explore emerging research trends, highlight thematic focus areas, and analyze patterns of collaboration within the field of AI-assisted pulmonary nodule research over the past 20 years.
    METHODS: A literature search was conducted in the Web of Science Core Collection to collect relevant studies published from 2005 to 2024 concerning the application of AI in pulmonary nodules. Bibliometric analysis was carried out using tools such as CiteSpace, VOSviewer, and the Online Analysis Platform of Literature Metrology to examine contributions from countries, institutions, authors, journals, keywords, and references.
    RESULTS: A total of 1,657 relevant publications were retrieved, reflecting a consistent upward trend in research output over the past two decades, with a marked acceleration observed after 2014. The leading contributors in terms of publication volume were China, the United States, and India. Shanghai Jiao Tong University stood out as the most prolific research institution. Analysis of keyword co-occurrence revealed several prominent thematic clusters, notably centered around Deep Convolutional Neural Network models, major diameter, lung nodule detection, false-positive reduction, cancer diagnosis, quantitative-semantic models, double reading, and clinical utility studies.
    CONCLUSIONS: This bibliometric study offers a thorough assessment of the scholarly landscape concerning AI applications in pulmonary nodule research, underscoring major developments and key contributors. The insights gained may serve as a strategic reference for researchers in the medical and AI fields, facilitating informed future directions. Notably, the intersection of AI and pulmonary nodule research is concentrated in the following areas: 1. Application of AI in pulmonary nodule detection and classification; 2. AI in malignancy risk prediction and growth modeling; 3.AI-driven development of drug efficacy evaluation metrics may be a future direction for pulmonary nodule treatment research.
    Keywords:  artificial intelligence; early-stage lung cancer; hot spots; pulmonary nodule; research trends
    DOI:  https://doi.org/10.1097/JS9.0000000000003059
  55. Front Sports Act Living. 2025 ;7 1604232
    Quantitative analysis and evaluation of research on the application of computer vision in sports since the 21st century.
    Cheng Chen, Jiaxin Xue, Wenling Gou, Mengning Xie, Xiaolin Yao.
       Introduction: Integrating computer vision with sports has significantly transformed competitive, educational, and recreational sports practices. A review of the literature in this field is imperative. The purpose of this paper is to reveal the field's temporal, disciplinary, geographic, journal, and collaborative characteristics and summarize research themes and future trends to promote a systematic understanding of the field within the academic community.
    Methods: To identify research trends, a bibliometric analysis of 1,209 publications retrieved from the Science Citation Index Expanded in the Web of Science core database was conducted.
    Results: In terms of time series, publications in the field grew slowly until 2014, and publications in the field increased significantly after 2015, with polynomial models predicting 206, 233, and 263 annual publications over the next three years. In terms of disciplinary structure, three frontier disciplines utilized interdisciplinary knowledge provided by four basic disciplines to make cutting-edge breakthroughs. Geospatially, there is a three-way split between China, the United States, and the United Kingdom, while most African countries are not involved in the research. Regarding journal distribution, research in this field was published in five Q2 and four Q1 journals, mainly in computing, with fewer contributions from sports journals. The study identifies five principal research themes: skill optimization, health monitoring and injury prevention, physical performance assessment, tactical analysis and referee assistance, and immersive event experiences. Furthermore, it highlights existing research limitations and outlines directions for future exploration.
    Conclusions: Computer vision research in sports has shown high explosive growth in recent years. The field is interdisciplinary but lacks collaboration among interdisciplinary research teams. The quality of the journals published is high, but the main focus is on computer-based journals. The theme of research in this field is centered on the fundamental characteristic of serving human beings.
    Keywords:  artificial intelligence; computer vision; health monitoring; injury prevention; referee assistance; sports
    DOI:  https://doi.org/10.3389/fspor.2025.1604232
  56. Pharmaceuticals (Basel). 2025 Jun 30. pii: 983. [Epub ahead of print]18(7):
    Natural Products for Drug Discovery in Cognitive Disabilities: Bibliometric Hotspots, Research Trends, Conceptual Framework, and Future Directions.
    Mohammed Albratty, Maryam Halawi, Ali Mufraih Albarrati.
      Background: The therapeutic potential of natural products in cognitive disabilities has drawn growing attention, yet a comprehensive analysis of trends and key contributors is lacking. This study provides a bibliometric overview highlighting growth patterns, themes, and future directions. Methods: A comprehensive Scopus search with multistep filtering was conducted by applying keywords related to natural products and cognitive disabilities to titles, abstracts, and keywords, initially retrieving 10,011 documents. Filters for original articles and English language reduced the results to 5688. Data extracted in October 2024 were analyzed using Excel and the R-package, yielding performance and citation indices. Differential proliferation was visualized using a Sankey diagram, while thematic maps highlighted key research themes, geographic trends, and subject clusters. Results: The field exhibited an annual growth rate of 12.36% from 1971 to 2024, with 2021 being the most productive year (497 articles). In recent decades, citation metrics have highlighted significant impacts. Thematic maps and Sankey diagrams revealed the research focus, geographic trends, and collaboration. Alzheimer's disease dominates the field, alongside topics such as oxidative stress, neuroprotection, and molecular docking. Emerging trends include ferroptosis, UPLC-Q-TOF-MS, and network pharmacology, which have marked advancements in therapeutic and computational approaches. Conclusions: This analysis underscores the dynamic and interdisciplinary nature of this field, highlighting areas for future exploration, particularly underrepresented cognitive disorders and novel therapeutic approaches.
    Keywords:  bibliometric analysis; cognitive disabilities; emerging trends; natural products; neuroprotection
    DOI:  https://doi.org/10.3390/ph18070983
  57. J Alzheimers Dis. 2025 Jul 28. 13872877251362665
    Frailty in Alzheimer's disease: A bibliometric analysis of research hotspots, emerging trends, and knowledge structure.
    Luya Shi, Xijiang Tian, Xiaoyu Lu, Bongsook Yih, Jiameng Chen.
      BackgroundFrailty has emerged as a major public health concern in aging populations, particularly among individuals with Alzheimer's disease (AD), where it exacerbates adverse outcomes and signals dementia progression. While research on frailty in AD has grown rapidly, a thorough analysis of key research hotspots and trends remains insufficient.ObjectiveThis study employs bibliometric methods to systematically explore core themes, identify potential frontiers and emerging directions in this field.MethodsOn December 27, 2024, a comprehensive search was conducted in the Web of Science Core Collection (WoSCC) database using keywords associated with frailty in AD. Bibliometric and knowledge mapping analyses were carried out using CiteSpace, VOSviewer, and R software.ResultsBetween 2005 and 2024, a total of 915 publications on frailty in AD were produced by 5950 researchers from 2084 institutions spanning 70 countries. Recent research in this field predominantly focuses on disciplines such as molecular biology, neuroscience, and pharmacology. Current studies emphasize interventions for frailty in patients with AD and the investigation of underlying pathological mechanisms, particularly concerning nutritional status and the influence of long COVID on frailty in AD. Emerging research themes include intervention strategies, mouse models, effects of long COVID, nutritional factors, mechanistic studies, brain fog, and subjective cognitive decline.ConclusionsThis bibliometric analysis highlights research frontiers on frailty in AD, emphasizing early monitoring and management of frailty are pivotal approaches to decelerate AD progression and improve patient outcomes. These findings offer valuable insights for future research, helping to address critical needs in patient care and disease management.
    Keywords:  Alzheimer's disease; Bibliometrix; CiteSpace; VOSviewer; bibliometric analysis; frailty
    DOI:  https://doi.org/10.1177/13872877251362665
  58. J Surg Educ. 2025 Jul 26. pii: S1931-7204(25)00179-5. [Epub ahead of print]82(9): 103598
    Publication Trends of Integrated Plastic Surgery Residency Applicants Without Numeric Step 1 Scores.
    Forrest Bohler, James R Burmeister, Ethan Dimock, Ava Harvey, Zachary A Koenig, Kongkrit Chaiyasate, Cameron J Davidson.
       INTRODUCTION: Little is known regarding the impact of the Step 1 score shift on the importance of publications for applicants to integrated plastic surgery residencies. The Class of 2024 represents the first cohort of integrated plastic surgery residents to match without a numeric Step 1 score.
    METHODS: A bibliometric analysis of 555 integrated plastic surgery residents from the 3 most recent graduating medical school cohorts was conducted in September 2024. Data included publication count, authorship status, article type, and journal quality indicators.
    RESULTS: The average number of publications for all residents analyzed was 7.33 and remained relatively consistent between classes. The percentage of applicants matching without any publications declined within each subsequent class, from 16.9% (PGY-3) to 15.2% (PGY-2) and 9.3% (PGY-1). Similarly, matched applicants without a first-author publication decreased from 37.1% and 38% in the PGY-3 and PGY-2 classes to 29.5% in the PGY-1 class. Furthermore, the proportion of applicants matching without a publication in a plastic surgery journal dropped steadily by ∼8% annually. Matched international medical graduates were responsible for a disproportionately greater number of publications than U.S. graduates. Residents at Top-20 programs exhibited 50% more publications than nontop 20 programs. The average 2-year impact factor among all publications was 3.6 and remained relatively consistent between classes. Among publications in plastic surgery journals, Plastic and Reconstructive Surgery was the most common. Clinical research articles were the most common article type analyzed.
    CONCLUSIONS: The Step 1 pass/fail transition hasn't significantly changed total publication output but has emphasized first-author, plastic surgery-specific publications, and having at least 1 publication. Residency directors may increasingly be utilizing these metrics as soft criteria for selection.
    Keywords:  USMLE Step 1; medical education; medical student research; plastic surgery; plastic surgery match
    DOI:  https://doi.org/10.1016/j.jsurg.2025.103598
  59. J Multidiscip Healthc. 2025 ;18 4243-4266
    Global Trends in Non-Invasive Techniques for the Diagnosis and Monitoring of Nonalcoholic Fatty Liver Disease: A Bibliometric and Visualization Analysis.
    Jing-Wen Cai, Wei-Long Wang, Dong-Ling Lin, Shu-Feng Ren, Qian-Qian Jia, Xiao-Xuan He, Xue-Xia Yang, Wen Cai, Hui Hou.
       Background: Nonalcoholic fatty liver disease (NAFLD) is a globally prevalent condition. Emerging technologies like biomarkers, imaging, multi-omics, and artificial intelligence (AI) are driving research into non-invasive diagnosis and monitoring.
    Objective: To provide a comprehensive overview of the hotspots and future research trends in non-invasive diagnosis and monitoring of NAFLD.
    Methods: A search of the Web of Science Core Collection database identified 1136 articles that met the study criteria between April 1, 2005, and December 31, 2024. By integrating various bibliometric methods and tools, we conducted a comprehensive analysis.
    Results: Publication growth reflects robust research interest. The United States and China are the leading countries, and the University of California, San Diego tops the institutions. Liver International and PLOS ONE publish the most relevant articles, while Journal of Hepatology is the most influential. "Transient elastography", "fibrosis" and "diagnosis" are prominent keywords. Research trends are shifting from basic to clinical applications, with a focus on non-invasive techniques, biomarkers and disease models.
    Conclusion: Future investigations will focus on the clinical application of these techniques. Global collaboration is expected to enhance NAFLD diagnosis, treatment, prevention, and monitoring.
    Keywords:  bibliometric analysis; non-invasive techniques; nonalcoholic fatty liver disease; visualization
    DOI:  https://doi.org/10.2147/JMDH.S525751
  60. Front Med (Lausanne). 2025 ;12 1593985
    Biomaterial-driven regenerative drug delivery: a vicennial bibliometric landscape.
    Xin Shen, Haobin Deng, Jing Lin, Jianhua Wang, Yilun Liu, Shikun Mo.
       Introduction: Biomaterials are increasingly central to innovations in drug delivery and regenerative medicine, driving new therapeutic strategies for chronic diseases and tissue repair. Despite rapid growth, a comprehensive, data-driven overview of this evolving interdisciplinary landscape has been lacking.
    Methods: Here, we present a bibliometric analysis of articles and reviews published in the Science Citation Index Expanded (Web of Science Core Collection) from January 2005 to December 2024.
    Results and discussion: The findings present a bibliometric visualization that highlights key trends in publication volume, geographical distribution of research, leading institutions, top journals, research categories, and emerging keywords. Cross-disciplinary integration of biomaterials, regenerative medicine, and drug delivery is accelerating advances in stem cell-based therapies, tissue engineering, and precision drug delivery platforms. Promising frontiers include personalized medicine, organoids, organ-on-chip technologies, and digital modelling of cellular systems. However, significant challenges remain in scalability, safety, and regulatory translation. This work provides a comprehensive reference for navigating current trends and identifying future opportunities in biomaterial-driven regenerative drug delivery.
    Keywords:  biblio metrics; biomaterials; drug delivery; regenerative medicine; tissue engeneering
    DOI:  https://doi.org/10.3389/fmed.2025.1593985
  61. Int J Environ Res Public Health. 2025 Jul 17. pii: 1128. [Epub ahead of print]22(7):
    Global Research Trends on Water Contamination by Microorganisms: A Bibliometric Analysis.
    Zoila Isabel Cárdenas Tirado, Isaías Wilmer Duenas Sayaverde, Rosario Del Socorro Avellaneda Yajahuanca, Sdenka Caballero Aparicio, Kelly Myriam Jiménez de Aliaga, Edo Gallegos Aparicio, Maria Antonieta Rubio Tyrrel, Maria do Livramento Fortes Figueiredo, José Wicto Pereira Borges, Rosilane de Lima Brito Magalhães, Denise Andrade, Daniela Reis Joaquim de Freitas, Ana Raquel Batista de Carvalho, Maria Eliete Batista Moura.
      Water is an essential resource for life; however, the quality of available water on the planet has been compromised due to various factors, including microbiological contamination.
    OBJECTIVE: To analyze the global scientific production of microbiological water contamination using bibliometric methods.
    METHOD: A search for scientific articles was conducted using the advanced query function in the Web of Science™ database, specifically in its core collection, on 26 February 2025. Data from 2000 articles were analyzed using the Bibliometrix package in R (version 4.2.1) and the Biblioshiny application (version 2.0).
    RESULTS: The evaluated articles were published between 1952 and 2025, with a peak in publications in 2022. The journal Water Research stood out as the most relevant, publishing 128 articles. The Egyptian Knowledge Bank was identified as the most productive institution, while China had the highest number of contributing authors. The most cited article received 475 citations. Additionally, KeyWords Plus™ highlighted the focus of the studies on ecological and biotechnological methods for contaminant removal, as well as the presence of waterborne pathogens and their inactivation methods.
    CONCLUSIONS: The results show a growing interest in the development of ecological and biotechnological methods for contaminant removal and pathogen inactivation in water. The integration of artificial intelligence with real-time monitoring systems emerges as a promising strategy for improving water quality management. These findings highlight the relevance of the topic for public health and health education.
    Keywords:  disinfection; drinking water; filtration; microorganism; public health; water pollution; water quality; water treatment; waterborne diseases; waterborne pathogens
    DOI:  https://doi.org/10.3390/ijerph22071128
  62. JMIR Med Inform. 2025 Jul 28. 13 e72225
    Pharmacoepidemiologic Research Based on Common Data Models: Systematic Review and Bibliometric Analysis.
    Yongqi Zheng, Meng Zhang, Conghui Wang, Ling Gao, Junqing Xie, Peng Shen, Yexiang Sun, Mengling Feng, Seng Chan You, Feng Sun.
       Background: The adoption of common data models (CDMs) has transformed pharmacoepidemiologic research by enabling standardized data formatting and shared analytical tools across institutions. These models facilitate large-scale, multicenter studies and support timely real-world evidence generation. However, no comprehensive global evaluation of CDM applications in pharmacoepidemiology has been conducted.
    Objective: This study aimed to conduct a systematic review and bibliometric analysis to map the landscape of CDM usage in pharmacoepidemiology, including publication trends, institutional authors and collaborations, and citation impacts.
    Methods: In total, 5 English databases (PubMed, Web of Science, Embase, Scopus, and Virtual Health Library) and 4 Chinese databases (CNKI, Wan-Fang Data, VIP, and SinoMed) were searched for studies applying CDMs in pharmacoepidemiology from database inception to January 2024. Two reviewers independently screened studies and extracted information about basic publication details, methodological details, and exposure and outcome information. The studies were categorized into 2 groups according to their Total Citations per Year (TCpY), and a comparative analysis was conducted to examine the differences in characteristics between the 2 groups.
    Results: A total of 308 studies published between 1997 and 2024 were included, involving 1580 authors across 32 countries and 140 journals. The United States led in both publication volume and citation counts, followed by South Korea. Among the 10 most cited studies, 7 used the Vaccine Safety Datalink, 2 used Sentinel, and one used Observational Medical Outcomes Partnership. Studies were stratified by TCpY to reduce citation bias from publication timing. Comparative analysis showed that high-TCpY studies were significantly more associated with multicenter collaboration (P=.008), United States-based institutions (P=.04), and vaccine-related research (P=.009). These studies commonly featured larger sample sizes, cross-regional data, and enhanced generalizability. International collaborations primarily occurred among North America, Europe, and East Asia, with limited involvement from limited-income countries.
    Conclusions: This study presents the first bibliometric overview of CDM-based pharmacoepidemiologic research. The consistent output from United States institutions and increasing engagement from South Korea underscore their central roles in this field. High-TCpY studies tend to be multicenter, collaborative, and vaccine-focused, reflecting structural factors linked to research visibility and influence. Stratified citation analysis supports the value of real-world data integration and international cooperation in producing impactful studies. The dominance of limited-income countries in collaboration networks highlights a need for broader inclusion of underrepresented regions. These findings can help researchers identify key contributors, guide partner selection, and target appropriate journals. As CDM-based methods continue to expand, fostering diverse and collaborative research efforts will be crucial for advancing pharmacoepidemiologic knowledge globally.
    Keywords:  bibliometric analysis; common data model; pharmacoepidemiology; systematic review
    DOI:  https://doi.org/10.2196/72225
  63. Brain Sci. 2025 Jul 16. pii: 754. [Epub ahead of print]15(7):
    Neuromodulation Interventions for Language Deficits in Alzheimer's Disease: Update on Current Practice and Future Developments.
    Fei Chen, Yuyan Nie, Chen Kuang.
      Alzheimer's disease (AD) is a leading cause of dementia, characterized by progressive cognitive and language impairments that significantly impact communication and quality of life. Neuromodulation techniques, including repetitive transcranial magnetic stimulation (rTMS), transcranial direct current stimulation (tDCS), and deep brain stimulation (DBS), have emerged as promising interventions. This study employs bibliometric analysis to evaluate global research trends in neuromodulation treatments for AD-related language impairments. A total of 88 publications from the Web of Science Core Collection (2006-2024) were analyzed using bibliometric methods. Key indicators such as publication trends, citation patterns, collaboration networks, and research themes were examined to map the intellectual landscape of this field. The analysis identified 580 authors across 65 journals, with an average of 34.82 citations per article. Nearly half of the publications were produced after 2021, indicating rapid recent growth. The findings highlight a predominant focus on non-invasive neuromodulation methods, particularly rTMS and tDCS, within neurosciences and neurology. While research activity is increasing, significant challenges persist, including ethical concerns, operational constraints, and the translational gap between research and clinical applications. This study provides insights into the current research landscape and future directions for neuromodulation in AD-related language impairments. The results emphasize the need for novel neuromodulation techniques and interdisciplinary collaboration to enhance therapeutic efficacy and clinical integration.
    Keywords:  Alzheimer’s disease; DBS; language; neuromodulation; rTMS; rehabilitation; tDCS
    DOI:  https://doi.org/10.3390/brainsci15070754
  64. J Cardiothorac Surg. 2025 Jul 31. 20(1): 320
    Knowledge domains and hotspots in corticosteroid use for cardiac surgery: a 23-Year bibliometric and visualized analysis.
    Wan-Wan Zou, Qi-Kun Zhu, Song Yang, En-Ze Bian, Wei-Zhong Zhuang, Jian-Zheng Cen, Qiang Gao.
       BACKGROUND: The safety and efficacy of prophylactic corticosteroid administration during the perioperative period of cardiac surgery have undergone extensive and comprehensive examination. In this study, we conducted a bibliometric analysis of publications addressing corticosteroid use in the perioperative period of cardiac surgery, aiming to elucidate the principal research trajectories and emerging trends spanning the past 23 years.
    METHODS: We performed a search in the Web of Science Core Collection for publications related to the application of corticosteroids during the perioperative period of cardiac surgery, spanning from the year 2000 to October 30, 2023. Bibliometric analysis was conducted employing the biblioshiny package in R, VOSviewer, and CiteSpace.
    RESULTS: We identified 293 eligible publications concerning corticosteroid use during the perioperative period of cardiac surgery. Publication volume increased significantly in 2001 and 2014. Keyword co-occurrence analysis revealed four primary clusters: cardiopulmonary bypass, systemic inflammatory response, methylprednisolone, and dysfunction. Over recent decades, research focus has shifted from examining how prophylactic corticosteroid use attenuates postoperative inflammation to investigating its potential effects on clinical complications following cardiac surgery.
    CONCLUSIONS: Considerable heterogeneity in inflammatory response phenotypes among individuals may lead to significant differences in the clinical effectiveness of prophylactic corticosteroid interventions. Thus, developing personalized treatment strategies should become a major focus in future research.
    Keywords:  Bibliometric; Cardiac surgery; CiteSpace; Corticosteroids; VOSviewer
    DOI:  https://doi.org/10.1186/s13019-025-03552-1
  65. J Craniofac Surg. 2025 Jul 25.
    Exploring Multifactorial Conflicts and Resolution Strategies in the Field of Peri-Implant Osseointegration: A Study Based on the WOE-NLP-Delphi Framework and Bibliometrics.
    Sirui Liu, Zixuan Liu, Shuai Zhang, Zhaoxin Ji, Qiang Sun, Qingsong Jiang.
      Titanium implants remain the gold standard for dental and orthopedic rehabilitation, yet challenges in osseointegration and postoperative infection persist. This study integrated bibliometric analysis with an AI-driven framework (DeepSeek-R1) to map global research trends, quantify technical conflicts, and predict future translational trajectories. Analyzing 3078 publications (2015-2025) from Web of Science, the authors identified China as the most productive country (251 articles), while Switzerland led in citation impact (25 citations/article). Key institutions included Sichuan University (251 publications) and Seoul National University (183 publications). Methodologically, the authors introduced a Weight of Evidence-Natural Language Processing-Delphi (WOE-NLP-Delphi) model to quantify core technical conflicts, revealing critical trade-offs: anti-inflammatory versus angiogenesis (conflict intensity=3.5), surface roughness versus inflammation (3.0), and antibacterial versus osteogenic activity (2.5). Technology Readiness Level (TRL) coupled with quantum Monte Carlo simulations predicted titanium surface topooptimization (TRL=6.8, R²=0.89) as clinically translatable, while flagging risks in sulfur-doped PEEK/Zn composites. Our findings highlight 3D-printed antimicrobial peptide coatings as high-potential candidates. This study establishes a paradigm for resolving multifactorial conflicts in implant engineering, offering data-driven insights to accelerate clinical translation.
    Keywords:  Artificial intelligence; bibliometrics; osseointegration; technology readiness level; titanium implants
    DOI:  https://doi.org/10.1097/SCS.0000000000011679
  66. Digit Health. 2025 Jan-Dec;11:11 20552076251361614
    Mapping the landscape of machine learning in chronic disease management: A comprehensive bibliometric study.
    Shiying Shen, Wenhao Qi, Sixie Li, Jianwen Zeng, Xin Liu, Xiaohong Zhu, Chaoqun Dong, Bin Wang, Qian Xu, Shihua Cao.
       Objective: This study aims to reveal global advancements and trends in machine learning (ML) for chronic disease management through a comprehensive bibliometric analysis, identifying research priorities to guide deeper exploration in the future.
    Methods: Relevant documents on ML and chronic disease management were retrieved from the core Web of Science database. Visual analyses of publication volume, research institutions, and countries were conducted using CiteSpace, VOSviewer, RStudio, and other software. An expert panel further analyzed the scale, trends, and potential connections between various ML algorithms and chronic diseases.
    Results: A total of 1,242 documents were included in this study. The findings indicate a continuous rise in studies on ML in chronic disease management, with the United States (n = 303, 23.5%) and China (n = 259, 20.1%) as primary research contributors. Logistic regression (n = 459) remains the most widely used algorithm, while neural networks (n = 183) show promising potential. Research hotspots are concentrated in diabetes and cardiovascular disease, focusing mainly on risk prediction, disease diagnosis, and personalized treatment.
    Conclusion: ML is rapidly integrating into personalized medicine, real-time monitoring, and multimodal data fusion. However, challenges such as limited collaboration, weak model generalization, and data privacy persist. Future efforts should prioritize algorithm optimization and multisource data integration to advance clinical applications.
    Keywords:  Machine learning; artificial intelligence; bibliometrics; chronic disease; data visualization; disease management
    DOI:  https://doi.org/10.1177/20552076251361614
  67. Mar Pollut Bull. 2025 Jul 31. pii: S0025-326X(25)00950-6. [Epub ahead of print]221 118475
    Global trends, hotspots and future prospects of ecological resilience of coastal wetlands: A bibliometric analysis.
    Changhong Xiao, Junhong Bai, Guozhu Chen, Langying Long, Jichen Qiu, Yuhao Xu, Tian Xie, Lijuan Cui.
      Coastal wetlands are sensitive to global change while they exhibit strong resilience to disturbances. This study aims to explore the developmental trajectory and future research trends of ecological resilience in coastal wetlands. A total of 3160 publications from 1980 to 2024 were selected from the Web of Science Core Collection and bibliometrically analyzed using CiteSpace and VOSviewer. The results indicated that the research field has experienced rapid growth and development since 2005. Research hotspots have shifted from exploring the resilience of single species or communities to entire ecosystems. The research focus has evolved from investigating the post-disturbance changes in coastal wetland ecosystems to predictive modeling frameworks after disturbances. Notably, there are increasing studies on the mechanisms of ecosystem resilience evolution and the applications of nature-based solutions. Future research should focus on revealing how ecosystems adapt to and recover from disturbances, and enhancing the overall ecological resilience of coastal wetlands.
    Keywords:  CiteSpace; Coastal wetlands; Hotspots; Resilience; VOSviewer; Visualization analysis
    DOI:  https://doi.org/10.1016/j.marpolbul.2025.118475
  68. Clin Exp Rheumatol. 2025 Jul 22.
    Bibliometric insights into transforming the management of rheumatoid arthritis: three decades of progress against opportunistic infections.
    Wenzhong Hu, Yun Xu.
       OBJECTIVES: The aim of this study was to investigate the research trends, patterns of opportunistic infections in rheumatoid arthritis (RA) and their impact on patient management strategies, especially in the context of the widespread use of DMARDs.
    METHODS: Research papers on RA and opportunistic infections were analysed by performing a literature search in the Web of Science Core Collection (WoSCC) database, covering the period from January 1, 1994 to December 31, 2023. Bibliometric analyses were performed using VOS viewer and Cite Space software, including country and institution analyses, journal and co-citation journal analyses, author and co-citation author analyses, and key word co-occurrence and clustering analyses.
    RESULTS: Two hundred and ninety-three research papers were analysed, and it was found that research publications on RA-associated opportunistic infections have shown a general upward trend over the past three decades, with a significant increase especially between 2007 and 2021. Japan, the United States, and China have the highest research output in this area, with institutions such as Yang Ming University and Taichung Veterans General Hospital being more active. Key word analysis revealed 'infection', 'risk', 'treatment', and 'infliximab' as research hotspots. Cluster analysis showed that tuberculosis, latent tuberculosis infection and hepatitis B virus were the focus of attention.
    CONCLUSIONS: Research on opportunistic infections in RA has shown a clear trend of growth and extensive international collaboration, reflecting a deep understanding of the risk of opportunistic infections in RA patients treated with DMARDs. Future studies should strengthen the identification of high-risk patient groups, the use of biomarkers, the balance of safety and efficacy in treatment regimens, and patient education to promote the optimisation of RA management strategies.
    DOI:  https://doi.org/10.55563/clinexprheumatol/7q3n0m
  69. J Health Popul Nutr. 2025 Aug 01. 44(1): 272
    Nutritional interventions in muscle hypertrophy research: a scientometric analysis within the context of resistance training (1992-2025).
    Wei Chen.
       BACKGROUND: Muscle hypertrophy, as a central goal in sports training, rehabilitation interventions, and health promotion, relies on scientifically designed resistance training and appropriate nutritional strategies. However, research on the synergistic effects of nutritional interventions and resistance training in promoting muscle hypertrophy is characterized by thematic fragmentation, insufficient integration between mechanistic and applied research, and imbalances across different regions and population groups.
    METHODS: To systematically delineate the developmental trajectory and emerging trends in this field, a comprehensive search was conducted in the Web of Science Core Collection, initially retrieving 456 publications. After rigorous screening and data cleaning, 411 English-language articles published between 1992 and 2025 were retained for analysis. Scientometric techniques were applied to construct knowledge maps using three major tools: Bibliometrix (R 4.4.3), VOSviewer (1.6.20), and CiteSpace (6.2.6). Bibliometrix was used to analyze publication trends and thematic evolution; VOSviewer to map keyword co-occurrence and collaboration networks; and CiteSpace to detect citation bursts and visualize knowledge structures. Collectively, these methods facilitated the identification of high-frequency keywords, hotspot transitions, collaborative patterns, and underexplored thematic gaps.
    RESULTS: The results indicate that: (1) the combination of protein supplementation and resistance training represents the most prominent intervention strategy; (2) a stable tripartite research model has emerged, centering on the interaction among training, nutrition, and structural adaptation; (3) the thematic focus has gradually shifted from molecular mechanisms toward practical applications, emphasizing issues such as aging and functional improvement; and (4) notable research gaps remain, particularly the underrepresentation of women and Asian populations, insufficient attention to recovery, metabolism, and periodized nutrition, and the lack of a systematic framework for individualized interventions.
    CONCLUSION: This study delineates the developmental trajectory, structural characteristics, and future directions of research in this field over the past three decades, providing empirical evidence and a theoretical foundation for the scientific formulation of muscle health enhancement strategies.
    Keywords:  Co-citation network; Interventions; Knowledge mapping; Muscle hypertrophy; Nutritional; Resistance training; Scientometric analysis
    DOI:  https://doi.org/10.1186/s41043-025-01031-w
  70. MethodsX. 2025 Dec;15 103497
    GeoBM: A Python-based tool for integrated visualization of global bibliometric data.
    Chun Chong Fu, Jorge Fleta-Asín, Fernando Muñoz, Carlos Sáenz-Royo, Loo Keat Wei.
      The rapid proliferation of scientometric and bibliometric analyses has emphasized the need for robust, scalable methods to visualize complex, large-scale research data. Conventional geospatial visualization techniques-most notably choropleth maps-often introduce significant distortions due to their inability to adequately account for spatial heterogeneity and overdispersion in bibliometric distributions. To address these methodological shortcomings, we propose GeoBM (Geographic Bibliometric Mapping), a computational framework that enables enhanced geovisualization of global scientific output and collaboration patterns. GeoBM integrates normalized country-level publication volumes with bilateral collaboration frequencies to produce high-resolution, interpretable geographic maps that reflect both research intensity and international connectivity. Implemented in Python, the framework leverages modular, algorithmically optimized routines for real-time data processing and visualization, incorporating statistical controls to mitigate overdispersion and enhance visual fidelity. The system supports extensive customization and is deployed via open-source platforms such as Google Colab and GitHub, facilitating broad accessibility and reproducibility. By providing a dual-focus representation of publication density and collaborative strength, GeoBM offers a powerful tool for the spatial analysis of global research networks, contributing to more nuanced evaluations in science policy, research management, and innovation studies.
    Keywords:  Bibliometric analysis; Bibliometrix; Citespace; Country collaboration map; Github; Google colab; Network; Production; Python algorithm; VOSviewer
    DOI:  https://doi.org/10.1016/j.mex.2025.103497
  71. PLoS One. 2025 ;20(7): e0320684
    Variability in article processing charges of open-access publishing across medical specialties.
    Emily G Tocco, Mackenzie M Mayhew, Margaret G Mercante, Nidhi Kuchimanchi, Mohamad El Moheb, Chengli Shen, Allan Tsung, Russell G Witt.
       BACKGROUND: Open-access (OA) journals provide public access to research but often impose a financial burden on researchers through article processing charges (APCs). The connection between APCs and indicators of journal prestige, such as journal impact factor (JIF), and their variation across medical specialties remains unclear. This study investigates how publication costs relate to journal prestige across diverse medical fields.
    METHODS: Data from 1,117 hybrid and OA journals across 29 medical specialties were compiled from Journal Citation Reports and journal websites. Pearson correlation coefficients between APCs and journal characteristics (JIF, journal citation indicator, citation counts, and percentage of OA publications) were calculated. Linear regression was used to assess the impact of these journal characteristics on APC variance. Bartlett's test for homogeneity of variances was performed to evaluate differences in APC variance across specialties and publishing models. Journal counts by country of origin and corresponding median APCs were also analyzed.
    RESULTS: Significant variation in APCs was observed across specialties, with hematology/oncology journals having the highest median APC ($4,690) and primary care journals the lowest ($2,690). Hybrid journals had higher median APCs than OA journals ($4,248 vs. $2,909, p < 0.001). JIF and the proportion of OA publications accounted for only 14.1% of the APC variance in Q1 journals. Weak positive correlations were found between APC and both JIF (r = 0.38) and citation counts (r = 0.38), and a weak negative correlation between APC and the proportion of OA publications (r = -0.28).
    CONCLUSIONS: Across all medical specialties, hybrid journals have higher APCs than fully open-access journals. Although APCs vary within specialties, differences across fields are less pronounced. The weak correlations between APC and journal prestige metrics suggest that factors such as JIF, citation counts, and the proportion of OA publications account for only a small fraction of APC variability.
    DOI:  https://doi.org/10.1371/journal.pone.0320684
  72. Med J Islam Repub Iran. 2025 ;39 43
    Advances in Radiotherapy and Chemoradiotherapy for the Treatment of Gastric Cancer (2014-2023): A Scientometric Approach.
    Iman Menbari Oskouie, Naghmeh Khavandgar, Hediyeh Alemi, Heydar Ali Mardani-Fard, Azadeh AleTaha, Amir-Hossein Mousavian, Nooshin Zomorodian, Ali Rahimi, Fattaneh Khalaj, Akbar Soltani, Majid Sorouri, Shirin Djalalinia, Amir Kasaeian.
       Background: Approximately 1,000,000 cases and 769,000 deaths from gastric cancer (GC) occurred in 2020, making it the fourth most prevalent reason for cancer-related fatalities. The objective of this study was to examine the use of radiation therapy (RT) and chemoradiotherapy (CRT) in GC using a quantitative and scientometric method.
    Methods: A comprehensive search was conducted in the Scopus database for articles on RT and CRT in GC from 2014 to 2023. We utilized the VOSviewer tool for a scientometric analysis covering various aspects such as countries, institutions, authors, journals, references, and keywords.
    Results: The study incorporated 15,036 articles related to the subject. China emerged as the top contributor, with the United States and Japan following. A significant positive correlation was found between the article output of countries on RT and CRT in GC and gross domestic product (GDP) and total wealth index, with correlation coefficients of 0.749 and 0.6921, respectively (P < 0.001). The forefront of institutional contribution was marked by the University of Texas MD Anderson Cancer Center. J.A. Ajani from the USA stands out as the most prolific author in this field, having published 112 articles. The leading journal was Frontiers in Oncology, and the most cited article in this domain was authored by Smyth, E.C., in 2020, in The Lancet. Author keywords revealed 6 clusters, with "Esophageal cancer" (655 mentions) and "Gastric cancer" (379 mentions) being the most prevalent.
    Conclusion: This pioneering scientometric study provides a comprehensive overview of the current state of research on RT and CRT about GC, evaluating the scholarly output in this field over the past decade. It can be concluded that this research topic has gained significant attention since 2016. While international collaborations are taking place worldwide, there is a need for more support and the expansion of research on RT and CRT in GC, especially in less developed countries. This study provides support to healthcare practitioners, researchers, and surgical aides regarding the global outcomes of RT and CRT in GC investigations.
    Keywords:  Bibliometric; Chemoradiotherapy; Gastric Cancer; Radiotherapy; Scientometric
    DOI:  https://doi.org/10.47176/mjiri.39.43
  73. Pak J Med Sci. 2025 Jul;41(7): 1861-1865
    Impact Factor Insights 2025: Analysis of Pakistani Academic Journals.
    Sultan Ayoub Meo, Shaukat Ali Jawaid.
      
    DOI:  https://doi.org/10.12669/pjms.41.7.12693
  74. Acta Odontol Latinoam. 2025 Apr;38(1): 246-255
    Dental fear and dental anxiety: bibliometric analysis of the 100 most frequently cited papers.
    Ana Clara F Paiva, Jennifer E Gallagher, Saul M Paiva, Cristiane B Bendo.
      Dental fear and anxiety are feelings that are often present at dental appointments and have been studied for a long time.
    AIM: To identify and critically review the 100 most frequently cited papers on dental fear and dental anxiety (DFA).
    MATERIALS AND METHOD: The 100 most frequently cited papers on DFA were retrieved from Web of Sciences (All databases) using a combined search strategy. Key bibliometric indicators were extracted. The methodological quality of the studies was assessed by the Mixed Methods Appraisal Tool (MMAT) except for reviews and systematic reviews, which were evaluated by the Joanna Briggs Institute (JBI) tool.
    RESULTS: Citations for the 100 most frequently cited papers ranged from 81 to 882. The largest number of papers was from the United States of America (22 papers; 3850 citations). Community Dentistry and Oral Epidemiology was the journal with highest number of papers (27 papers; 3153 citations). The most frequently cited author was Corah NL (1390 citations). Cross-sectional study design was the most common (67 studies). The topics covered by the studies were diverse, highlighting studies on the development and validation of assessment tools. There were 17 validated assessment tools, of which The Dental Anxiety Scale was the most often used (28 studies). There were five terms used to refer to DFA. Most papers were of intermediate quality.
    CONCLUSION: This bibliometric analysis identified the 100 most frequently cited papers on DFA and the topics covered. "Dental anxiety" was the term most often used, although more recent research includes both "fear" and "anxiety". The Dental Anxiety scale was the most frequently used assessment tool. Higher quality papers are encouraged to improve knowledge on DFA.
    Keywords:  bibliometrics; citations; dental anxiety; dental fear; dentistry
    DOI:  https://doi.org/10.54589/aol.38/1/59
  75. Omega (Westport). 2025 Jul 30. 302228251363788
    Near-Death Experiences: A Bibliometric and Systematic Review of Published Literature From 1977 to 2025.
    Sandra Barreto.
      Interest in near-death experiences (NDEs) has grown across disciplines such as medicine, psychology, and literature, yet no consensus exists on their origin or nature. This study presents a bibliometric and systematic review of 775 articles published between 1977 and April 2025, using PRISMA guidelines. Data was extracted from the Scopus database and analyzed with the Bibliometrix package in R. Additionally, the Tree of Science method was used to map citation networks and identify core contributions and research fronts. The United States, the United Kingdom, and Belgium lead in NDE research. Methodologies vary widely, encompassing medical analyses of brain activity, psychological outcomes like reduced suicidal ideation, and narrative approaches identifying common language patterns. Findings reveal a fragmented theoretical landscape, emphasizing the need for integrative frameworks. Future studies should deepen the medical and psychological understanding of NDEs and explore their long-term impact on individuals' mental health and spiritual development.
    Keywords:  bibliometric analysis; interdisciplinary research; near-death experiences; systematic review; tree of science
    DOI:  https://doi.org/10.1177/00302228251363788
  76. Front Med (Lausanne). 2025 ;12 1658371
    Correction: A bibliometric analysis of studies related to the nuclear factor kappa b signaling pathway in knee osteoarthritis between 2004 and 2023.
    Yafeng Mo, Jiahao Chu, Tiewu Chen, Wenbing Liu, Jing Tang.
      [This corrects the article DOI: 10.3389/fmed.2025.1572161.].
    Keywords:  NF-κB; bibliometric analysis; knee; osteoarthritis; signaling pathway
    DOI:  https://doi.org/10.3389/fmed.2025.1658371
  77. Bioengineering (Basel). 2025 Jul 19. pii: 783. [Epub ahead of print]12(7):
    Mapping the Global Research on Drug-Drug Interactions: A Multidecadal Evolution Through AI-Driven Terminology Standardization.
    Andrei-Flavius Radu, Ada Radu, Delia Mirela Tit, Gabriela Bungau, Paul Andrei Negru.
      The significant burden of polypharmacy in clinical settings contrasts sharply with the narrow research focus on drug-drug interactions (DDIs), revealing an important gap in understanding the complexity of real-world multi-drug regimens. The present study addresses this gap by conducting a high-resolution, multidimensional bibliometric and network analysis of 19,151 DDI publications indexed in the Web of Science Core Collection (1975-2025). Using advanced tools, including VOSviewer version 1.6.20, Bibliometrix 5.0.0, and AI-enhanced terminology normalization, global research trajectories, knowledge clusters, and collaborative dynamics were systematically mapped. The analysis revealed an exponential growth in publication volume (from 55 in 1990 to 1194 in 2024), with output led by the United States and a marked acceleration in Chinese contributions after 2015. Key pharmacological agents frequently implicated in DDI research included CYP450-dependent drugs such as statins, antiretrovirals, and central nervous system drugs. Thematic clusters evolved from mechanistic toxicity assessments to complex frameworks involving clinical risk management, oncology co-therapies, and pharmacokinetic modeling. The citation impact peaked at 3.93 per year in 2019, reflecting the increasing integration of DDI research into mainstream areas of pharmaceutical science. The findings highlight a shift toward addressing polypharmacy risks in aging populations, supported by novel computational methodologies. This comprehensive assessment offers insights for researchers and academics aiming to navigate the evolving scientific landscape of DDIs and underlines the need for more nuanced system-level approaches to interaction risk assessment. Future studies should aim to incorporate patient-level real-world data, expand bibliometric coverage to underrepresented regions and non-English literature, and integrate pharmacogenomic and time-dependent variables to enhance predictive models of interaction risk. Cross-validation of AI-based approaches against clinical outcomes and prospective cohort data are also needed to bridge the translational gap and support precision dosing in complex therapeutic regimens.
    Keywords:  Python; VOSviewer; Web of Science; bibliometric analysis; drug interaction checker; drug–drug interactions
    DOI:  https://doi.org/10.3390/bioengineering12070783
  78. Mar Pollut Bull. 2025 Jul 25. pii: S0025-326X(25)00958-0. [Epub ahead of print]221 118483
    Research hotspots and trends in Spartina alterniflora studies (1970-2023): A bibliometric analysis.
    Dandan Yan, Shanshan Wang, Peng Song, Yuqing Zhang, Yiming Huang, Yu Wang, Wenyan Zhu, Linlin Wu.
      Spartina alterniflora is native to the Atlantic coast of the United States but has gained attention globally as an invasive species. To improve understanding of S. alterniflora and identify future research priorities, this study presents a comprehensive bibliometric and quantitative trend analysis of 4551 publications from 1970 to 2023, using ScientoPy and VOSviewer. Results indicated a steady increase in publications on S. alterniflora. Term co-occurrence visualization analysis revealed that research has evolved through stages: from examining the species' physiological and ecological characteristics, to exploring its invasion mechanisms and impacts, and finally to developing control technologies and assessing its responses to global climate change. Quantitative trend analysis showed that China and the United States are at the forefront of S. alterniflora research. Keywords such as "Blue carbon," "Plant invasion," "Climate change," and "Remote sensing" exhibited high trend factors and normalized frequency change values, suggesting that future research will focus on S. alterniflora's role in blue carbon sequestration, salt marsh restoration, and climate response mechanisms. Notably, S. alterniflora's invasion has displaced native blue carbon ecosystems, which typically offer greater long-term carbon sequestration and lower greenhouse gas emissions. This shift has diminished regional net carbon sink function and increased the net greenhouse effect. Although S. alterniflora represents a considerable carbon stock, it also poses substantial ecological risks. Therefore, comprehensive ecological risk assessments and scientifically informed management strategies are essential to optimize environmental benefits while minimizing negative ecological impacts.
    Keywords:  Blue carbon; Climate change; Invasion; Research hotspot; Research trend; Spartina alterniflora
    DOI:  https://doi.org/10.1016/j.marpolbul.2025.118483
  79. Front Immunol. 2025 ;16 1590342
    Commentary: Bibliometric analysis of targeted immunotherapy for osteosarcoma-current knowledge, hotspots and future perspectives.
    Nan Zhang, Wanqing Li, Haiyang Wu, Qiang Guo.
      
    Keywords:  immune checkpoint inhibitor; immune function; immunotherapy; osteosarcoma; targeted therapy
    DOI:  https://doi.org/10.3389/fimmu.2025.1590342
  80. PRiMER. 2025 ;9 33
    Global Trends in Vitamin D Research From 1985 to 2024.
    Mudasir Umer, Syed Mustafa Ali Shah, Camille Moeckel, Erum Azhar, Faisal Aziz, Abdul Waheed.
       Introduction: Despite the importance of vitamin D, the number of vitamin D-related research publications has declined since 2020. This study examines trends in vitamin D-related research and National Institutes of Health (NIH) funding over 4 decades.
    Methods: We conducted a PubMed search using medical subject headings terms to identify vitamin D-related papers published between 1985 and 2024. NIH funding data were from NIH Reporter; statistical significance was determined using negative binomial regression.
    Results: Vitamin D-related publications rose steadily from 1985 to 2000, surged from 2008 to 2021, peaked at 6,019 in 2021, and then declined. A similar trend was seen in research on vitamin D-associated diseases. NIH funding for vitamin D research peaked at $52.4 million in 2013 but decreased to $10.5 million by 2024. A negative binomial regression showed a significant difference in publication rates (P<.001) in Vitamin D-related publications with "year" being a significant predictor across all models (P<.05). Negative binomial regression across 4 decades showed an annual publication growth of Vitamin D-related papers of 1.44% (P=.002) from 1985 to 1994, 4.78% (P<.001) from 1995 to 2004, and 12.88% (P<.001) from 2005 to 2014. In contrast, during the years 2015 to 2024, the annual increase dropped to 0.63% (P=.389), indicating a decline in publication activity.
    Conclusions: Vitamin D research output surged through 2014 but has since lost momentum, declining from its 2021 peak and showing no significant annual growth from 2015 to 2024 (P=.389). These findings regarding vitamin D-related research raise important questions that remain unanswered.
    DOI:  https://doi.org/10.22454/PRiMER.2025.538113
  81. BMC Cancer. 2025 Jul 29. 25(1): 1235
    Exploring research frontiers and emerging trends of tyrosine kinase inhibitors in the treatment of colorectal cancer.
    Xiaosong Li, Zhenlong Chen, Jie Yin, Xiping Shen, Hang Li.
       BACKGROUND: Tyrosine kinase inhibitors (TKIs) are a class of molecular targeted drugs designed to selectively inhibit tyrosine kinase activity associated with oncogenic signaling pathways and drivers, and have emerged as key therapeutic agents for colorectal cancer (CRC). The purpose of this study is to explore the research status and development trend of TKIs in CRC treatment.
    METHODS: The Web of Science Core Collection (WoSCC) database was systematically searched for publications related to TKIs for the treatment of CRC from 2015 to 2024. The CiteSpace visualization software were employed to visualization analysis.
    RESULTS: A total of 1151 papers published between 2015 and 2024 were included in this study. The USA was the most productive and influential country in this field. The University of Texas System and University of California System were identified as the most productive and most cited institutions, respectively. Cancers has the highest publication volume in this field. Trusolino Livio and Van Cutsem Eric were identified as the most prolific and most frequently co-cited authors, respectively. The article titled "Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways" published in Cancers in 2017, received the highest citation frequency. The emerging keywords that persisted into 2024 include "microsatellite instability", "biological evaluation", "drug discovery", "inhibitors", "regorafenib", "immunotherapy", and "T-cells".
    CONCLUSION: Current research hotspots include development of novel TKIs, elucidation of TKIs resistance mechanisms and corresponding overcoming strategies, evaluation of TKIs efficacy and safety through biological assessments, and combination of TKIs with immunotherapy. Precision medicine, multimodal combination therapies, and interdisciplinary integration represent the frontier research areas and future development directions.
    Keywords:  Colorectal cancer; Immunotherapy; Targeted therapy; Tumor microenvironment; Tyrosine kinase inhibitors
    DOI:  https://doi.org/10.1186/s12885-025-14639-2
  82. Int Heart J. 2025 ;66(4): 712-713
    Most Cited Articles in 2024.
      
    DOI:  https://doi.org/10.1536/ihj.66.712
  83. Microorganisms. 2025 Jul 16. pii: 1668. [Epub ahead of print]13(7):
    Bibliometrics and Visualization Analysis of Three Obligate Organohalide Respiring Bacteria Genera: A Systematic Review.
    Lisi Jiang, Zirui Yu, Jiaqi Qu, Xiaohan Xu, Zirui Liu, Wenyuan Li, Yang Zhang.
      Organohalide-respiring bacteria (OHRB) facilitate the reductive dehalogenation of toxic halogenated compounds in the environment, which supports their growth and proliferation. Research conducted on OHRB has achieved notable advancements. However, given the intricacy of the ecosystem and the methodologies employed for microbial isolation, numerous constraints persist. Further exploration is imperative to elucidate the physiological characteristics, ecological functions, and technological applications of OHRB. This study aimed to evaluate the outcomes and insights of prior research via a bibliometric analysis of three obligate OHRB genera-Dehalococcoides, Dehalobacter, and Dehalogenimonas-over a three-decade period from 1994 to 2024, based on the Web of Science (WOS) database. The results show that research on these three bacterial genera has advanced in sequence since the initiation of studies in this field. The research area encompasses the identification and isolation of novel OHRB species, the gene sequencing of related enzymes, and the role of microorganisms in the remediation of environmental pollutants, reflecting a gradual transition from individual investigations of OHRB to the applications of microorganisms in remediating complex environmental pollution. This study systematically reviewed the past research history of this field and conducted an in-depth analysis of research hotspots. The integration of this analysis with technological development trends and practical application requirements provides a theoretical basis and innovative concepts for future research directions in the field of ecological environment restoration.
    Keywords:  bibliometric; organohalide-respiring bacteria; reductive dechlorination
    DOI:  https://doi.org/10.3390/microorganisms13071668
  84. Integr Med Res. 2025 Sep;14(3): 101181
    Bibliometrics and altmetrics in the context of traditional, complementary, and integrative medicine.
    Jeremy Y Ng, Dimity Stephen, Jianping Liu, Thomas Ostermann, Nicola Robinson, Holger Cramer.
      This educational article explores the utility of bibliometrics and altmetrics in evaluating traditional, complementary, and integrative medicine (TCIM) research. We introduce the concept of bibliometrics and altmetrics, provide an overview of the opportunities and challenges in using these analytical techniques, and highlight their future potential in TCIM research. Bibliometrics, based on publication and citation information, offer insights into TCIM research activity, output, scholarly influence, field structure, and collaboration practices. Altmetrics, including social media mentions, downloads, and online bookmarks, can capture the broader societal engagement with TCIM research beyond traditional academic circles. We discuss challenges and opportunities in utilizing these metrics effectively, such as addressing biases, incorporating cultural nuances, and exploring emerging trends. Additionally, we issue a call to action for researchers, policymakers, and practitioners to collaborate and leverage bibliometric and altmetric data to advance evidence-based healthcare practices to promote integrative approaches to health and wellness. By embracing a multidimensional approach to research evaluation, stakeholders can harness the potential of bibliometrics and altmetrics to improve TCIM research and healthcare delivery worldwide.
    Keywords:  Altmetric; Bibliometrics; Complementary medicine; Integrative medicine; Traditional metrics
    DOI:  https://doi.org/10.1016/j.imr.2025.101181
  85. An Bras Dermatol. 2025 Jul-Aug;100(4):pii: S0365-0596(25)00110-2. [Epub ahead of print]100(4): 501168
    Anais Brasileiros de Dermatologia - Impact Factor and CiteScore for 2024⋆.
    Sílvio Alencar Marques, Ana Maria Roselino, Hiram Larangeira de Almeida Junior, Luciana Patrícia Fernandes Abbade.
      
    DOI:  https://doi.org/10.1016/j.abd.2025.501168
  86. J Surg Res. 2025 Jul 25. pii: S0022-4804(25)00338-5. [Epub ahead of print]
    Representation of Women as Editors of the Top Surgery Journals in the World.
    Alizeh Abbas, Britney Corey, Herbert Chen.
       INTRODUCTION: The objective of this study was to examine the current representation of women on editorial boards of the top surgery journals in the world.
    METHODS: We identified the top 80 surgery journals on a global scale using the Resurchify Surgery Journal Ranking. The names of each journal's editor-in-chief, deputy editors, and editorial board members were obtained from the journal's website. We used Google search and Gender API to determine the gender of each editorial board member. Descriptive statistical analyses were performed in Microsoft Excel.
    RESULTS: A total of 76 journals representing 15 surgical subspecialties were included in the study. Overall, 6065 editors, 1588 deputy editors, and 4395 editorial board members were included. Only 5 (6.6%) journals had a woman editor-in-chief. The top journals with the highest representation of women deputy editors were Otolaryngology-Head and Neck Surgery (100%) and the American Journal of Surgery (75%), with third place shared among five journals. The editorial boards of American Journal of Surgery (61.4%) and the Journal of Neurology, Neurosurgery, and Psychiatry (51%) had the highest representation of women editorial board members. The subspecialties with the greatest representation of women editors were breast surgery (30%), ophthalmology (25.3%), and miscellaneous (22.8%). Six neurosurgery and seven orthopedic surgery journals had no women deputy editors or editorial board members.
    CONCLUSIONS: Women remain underrepresented on surgery journal editorial boards. Understanding the gender composition of editorial boards of prestigious surgery journals is a key step for developing strategies aimed at increasing women's representation in surgical leadership positions.
    Keywords:  Academic medicine; Academic surgery; Editorial board; Journals; Surgical leadership; Women's representation in surgery
    DOI:  https://doi.org/10.1016/j.jss.2025.04.052
  87. Urology. 2025 Jul 29. pii: S0090-4295(25)00734-4. [Epub ahead of print]
    Editorial Comment for "GLOBAL COLLABORATION IN UROLOGICAL SURGERY RESEARCH BETWEEN HIGH- AND LOW-INCOME COUNTRIES: A BIBLIOMETRIC SCOPING REVIEW".
    Courtney Yong.
      
    DOI:  https://doi.org/10.1016/j.urology.2025.07.052
  88. J Am Coll Surg. 2025 Aug 01.
    Attrition in Academic Research Among Plastic Surgeons: A Longitudinal Cohort Study Across 3 Decades.
    Lauren S Lowe, Dylan K Kim, Lee D Yang, Maggie H Zhou, Christine H Rohde.
       INTRODUCTION: Attrition from academic research, defined as cessation of publication, may be influenced by access barriers to professional and academic development. It is currently unknown how these considerations affect plastic surgeons, despite trends of increasing research demands in the field. This study quantifies trends in academic attrition among currently practicing plastic surgeons across three decades.
    METHODS: A longitudinal cohort study was conducted with a cohort of American plastic surgeons with academic publications since 2000. The main outcome of interest was attrition, quantified as a lack of academic publication in the last three years or more. The probability of attrition over time was measured with Kaplan-Meier curves, and predictors of attrition were evaluated with a Cox proportional hazards model (p<0.05).
    RESULTS: The final cohort included 1,681 currently practicing plastic surgeons. The overall rate of attrition was 57.6%. Male gender (HR: 0.76, 95% CI: 0.65-0.89, p<0.001), academic affiliation (HR: 0.74, 95% CI: 0.64-0.86, p<0.001), and certain types of fellowship training (p<0.05) independently predicted a lower likelihood of attrition over time. In a sensitivity analysis that included only those who began publishing in 2010 or later, gender was no longer a significant predictor of attrition (HR: 0.98, 95% CI: 0.75-1.29, p = 0.90).
    CONCLUSION: Attrition rates are predicted by surgeon gender, academic affiliation, and fellowship training. These trends highlight continued gender imbalances in the field of plastic surgery and the need for organizational shifts that foster growth for all physicians who desire to continue academic research.
    Keywords:  academic medicine; disparities; fellowship; plastic surgery; retention; surgical research
    DOI:  https://doi.org/10.1097/XCS.0000000000001541
  89. AEM Educ Train. 2025 Aug;9(4): e70082
    Resident Scholarly Activity and Productivity Outcomes Before and After Implementing a Structured Research Program: A Before-After Study.
    Sydney Krispin, Eric Kontowicz, Brett Faine, Michael Takacs, Karisa K Harland, J Priyanka Vakkalanka, Kelli Wallace, Andrew Nugent, Nicholas M Mohr.
       Objectives: Emergency medicine (EM) residency programs require participation in scholarly activity. In 2017, we launched a formal Resident Research Program (RRP) for physician residents in our 3-year accredited residency program. We aimed to measure the association between the implementation of the RRP and resident scholarly productivity.
    Methods: This analysis was a before-after study of residents in a Midwestern university-based EM residency program (7-10 per class) graduating between 2013 and 2023. The RRP was implemented in July 2017 and offered resources and requirements; our study compared outcomes before and after the launch of the program. We provided a dedicated training program study coordinator, 24-h in-house research assistants, faculty/research staff mentorship, and research funding. Residents were required to complete a hypothesis-driven research project and submit an abstract to a professional meeting or manuscript for publication. We tracked scholarly productivity per class, including publications, presentations, first-author manuscripts, and faculty publications with a resident. We measured the association between the RRP and scholarly productivity through univariate Poisson regression models to report the unadjusted rate ratio (RR) with 95% confidence intervals (95% CI).
    Results: Ninety residents were included (n = 43 after RRP launch). Annual mean resident scholarly productivity increased post-intervention for publications (10.4 vs. 6.2 publications per class, RR 1.68, 95% CI 1.09-2.59), presentations (7.4 vs. 3.7 abstracts per class, RR 2.01, 95% CI 1.19-3.42), and first-author publications (5.8 vs. 2.2 publications per class, RR 2.66, 95% CI 1.40-5.09). No significant change in faculty co-authors was observed (12.8 vs. 9.5, RR 1.35, 95% CI 0.95-1.92).
    Conclusions: The implementation of a structured RRP was associated with increased resident scholarly productivity. The targeted research resources served as both a strategy to support resident research and enhance departmental academic engagement. Future research should examine the perceptions, quality, and impact of scholarly activity requirements on residents.
    DOI:  https://doi.org/10.1002/aet2.70082
  90. PLoS One. 2025 ;20(8): e0329302
    Knowledge transfer, knowledge gaps, and knowledge silos in citation networks.
    Eoghan Cunningham, Derek Greene.
      The advancement of science relies on the exchange of ideas across disciplines and the integration of diverse knowledge domains. However, tracking knowledge flows and interdisciplinary integration in rapidly evolving, multidisciplinary fields remains a significant challenge. This work introduces a novel network analysis framework to study the dynamics of knowledge transfer directly from citation data. By applying dynamic community detection to cumulative, time-evolving citation networks, we can identify research areas as groups of papers sharing knowledge sources and outputs. Our analysis characterises the life-cycles and knowledge transfer patterns of these dynamic communities over time. We demonstrate our approach through a case study of eXplainable Artificial Intelligence (XAI) research, an emerging interdisciplinary field at the intersection of machine learning, statistics, and psychology. Key findings include: (i) knowledge transfer between these important foundational topics and the contemporary topics in XAI research is limited, and the extent of knowledge transfer varies across different contemporary research topics; (ii) certain application domains exist as isolated "knowledge silos"; (iii) significant "knowledge gaps" are identified between related XAI research areas, suggesting opportunities for cross-pollination and improved knowledge integration. By mapping interdisciplinary integration and bridging knowledge gaps, this work can inform strategies to synthesise ideas from disparate sources and drive innovation. More broadly, our proposed framework enables new insights into the evolution of knowledge ecosystems directly from citation data, with applications spanning literature review, research planning, and science policy.
    DOI:  https://doi.org/10.1371/journal.pone.0329302
This page is being maintained by Thomas Krichel. It was last updated on 2025‒08‒23 at 4:27.