bims-evares Biomed News
on Evaluation of research
Issue of 2025–07–13
87 papers selected by
Thomas Krichel, Open Library Society



  1. Front Immunol. 2025 ;16 1510549
       Background: Gliomas represent the most prevalent primary neoplasms of the central nervous system. Activating an immune response by dendritic cells is pivotal in glioma immunotherapy. This study offers a comprehensive bibliometric analysis to elucidate the role of dendritic cells in gliomas.
    Method: We extracted literature related to glioma and dendritic cells from 1992 to 2024 using the Web of Science Core Collection. Utilizing CiteSpace, Vosviewer and Microsoft Excel, we analyzed the volume of publications, the contributing countries/regions, institutions, authors, journals, references and keywords.
    Results: A total of 1,576 articles were included, revealing an annual surge in dendritic cell-focused glioma research. The USA, China and Germany were the leading countries in publication output. Okada, Hideho had the most publications, while Stupp, R had the highest co-citations. Journal of Neuro-Oncology published the most articles, and Cancer Research received the highest citations. The analysis highlights pivotal themes including "dendritic cell", "immunotherapy", and "glioblastoma", alongside emerging areas of interest such as "tumor microenvironment", "immune infiltration" and "double blind". Notably, the exploration of dendritic cell vaccinations is a key area of glioma therapeutic research, and there is growing interest in it.
    Conclusion: This study conducts a bibliometric analysis of publications related to dendric cells in glioma. Our findings suggest that dendritic cells, immunotherapy and glioblastoma will remain the focal points and emerging trends in dendritic cell-glioma research, providing valuable insights for future studies. Dendritic cell vaccines show promise in glioma trials but are hindered by the immunosuppressive tumor microenvironment. Future work should enhance dendritic cell function and explore combination therapies to improve outcomes.
    Keywords:  CiteSpace; VOSviewer; bibliometric analysis; dendritic cells; glioma; visualized
    DOI:  https://doi.org/10.3389/fimmu.2025.1510549
  2. Discov Oncol. 2025 Jul 07. 16(1): 1275
       PURPOSE: Autoimmune diseases are closely linked with lung cancer (LC), forming a complex bidirectional relationship that poses significant challenges to treatment. A bibliometric analysis was conducted to investigate global research trends, key hotspots, and potential future directions in this field.
    METHODS: This study utilized bibliometric methods, analyzing 1161 publications from the Web of Science database spanning the years 1980 to 2024. Visualization and analysis were performed using tools such as VOSviewer, CiteSpace, and the bibliometrix R package.
    RESULTS: The dataset encompassed research from 73 countries, 1860 organizations, and 6734 authors, published in 541 sources. The United States emerged as the leading contributor in terms of publication output, with the Mayo Clinic identified as the most productive institution. The Cureus Journal of Medical Science published the highest number of articles, whereas Chest garnered the most citations. Among individual researchers, Sasha Bernatsky stood out as the most prolific and frequently co-cited author. Keyword analysis revealed significant focus areas, including immune therapy-related adverse events, interstitial lung disease, comorbidities, diagnostic methods, and autoantibodies in paraneoplastic syndromes. Emerging research priorities center on understanding immune mechanisms, addressing comorbidities, and advancing diagnostic approaches.
    CONCLUSION: This bibliometric study provides a comprehensive overview of research trends and gaps in the intersection of autoimmune diseases and LC. It highlights the importance of exploring immune therapy mechanisms, managing comorbidities, and optimizing diagnostic strategies as key areas for future investigation.
    Keywords:  Autoimmune disease; Bibliometric analysis; Frontier hotspots; Global research trends; Lung cancer
    DOI:  https://doi.org/10.1007/s12672-025-03145-3
  3. Front Mol Neurosci. 2025 ;18 1613702
       Objective: This study explores potential therapeutic strategies by determining the current research status, hotspots, and development trends through bibliometric analysis of the PI3K/Akt in ischemic stroke (IS).
    Methods: We searched the Web of Science Core Collection for publications on IS and the PI3K/Akt pathway, covering January 1, 2010, to December 31, 2024. VOSviewer and CiteSpace software were used to analyze research hotspots and cutting-edge topics in the field and generate visual maps of relevant countries, institutions, authors, journals, keywords, and references.
    Results: A total of 635 publications were analyzed. The number of publications indicates a steady annual increase in research output. China, Capital Medical University, and Wang Lei were identified as the most prolific country, institution, and author, respectively. The top three contributing journals were Brain Research, Journal of Ethnopharmacology, and Frontiers in Pharmacology. Autophagy, microglia and neuroinflammation, bioinformatics approaches, and traditional Chinese medicine (TCM) are not only current research areas but also important trends for future research. Notably, targeting IS with TCM holds significant potential for translating basic research findings into clinical applications.
    Conclusion: This bibliometric analysis provides an in-depth overview of research on the PI3K/Akt pathway in IS, revealing current research status, hotspots, and future research trends. This will provide valuable guidance and direction for developing novel therapeutic strategies targeting this pathway.
    Keywords:  PI3K/AKT; bibliometric analysis; ischemic stroke; scientific networks; signaling pathways; visual analysis
    DOI:  https://doi.org/10.3389/fnmol.2025.1613702
  4. J Robot Surg. 2025 Jul 08. 19(1): 364
      This study utilizes the Scopus database and adopts a multi-layered approach to provide a comprehensive and detailed overview of robotic surgery research. Specifically, three complementary strategies: (a) a title-abstract-keyword (TAK) search, (b) a title-specific search, and (c) a focused analysis of the top 100 most cited papers were employed. The TAK approach retrieved 49,026 publications, substantially surpassing the 8,029 identified via the title-only method, demonstrating that incorporating abstracts and keywords provides broader coverage. Analysis of prolific authors revealed Mottrie, A. as the most productive researcher in the TAK dataset, while Fukuda, T. led in the title-only set. Leading institutions such as the Cleveland Clinic Foundation and Yonsei University College of Medicine exhibited markedly higher outputs under TAK criteria. Country-level analysis confirmed the United States as the dominant contributor in both datasets, though absolute counts dropped significantly when limited to titles. The Journal of Robotic Surgery emerged as the most productive source across both methods. Funding sponsor analysis highlighted the National Natural Science Foundation of China as the leading funder, with the TAK dataset revealing greater international sponsorship diversity. Citation analysis of the top 100 most cited documents, spanning 1993-2021, showed an average of 279.6 citations per article, with recent papers (2018-2021) achieving unprecedented citation velocity, suggesting earlier peaks in influence for newer publications. Keyword analysis of the top 150 most frequently occurring terms in the title-specific dataset helped to map key research directions. From the title-based corpus, the 100 most cited papers were analyzed, reporting their total citations, citations per paper, and citations per year. A detailed author-level analysis was performed, including publication count, citation impact, and scholarly indices (h-index, g-index, m-index), complemented by visualizations of collaboration networks. Moreover, this study incorporates a co-word analysis of the top 100 cited papers, using unigrams, bigrams, and trigrams to illustrate central themes. The top 20 most cited papers are briefly discussed. The findings offer updated, actionable insights for researchers, clinicians, and policymakers seeking to navigate this rapidly advancing field.
    Keywords:  Bibliometric analysis; Citation analysis; Co-word analysis; Most cited papers; Robotic surgery; Scopus; Title-abstract-keyword search; Title-specific search
    DOI:  https://doi.org/10.1007/s11701-025-02542-8
  5. Beyoglu Eye J. 2025 ;10(2): 107-116
       Objectives: This study set out to comprehensively analyze and compare the scientific impact, productivity, and collaboration networks of seven ophthalmology journals published in Türkiye, using the Dimensions, Tübitak/Ulakbim and SCImago databases.
    Methods: The study examined various bibliometric indicators, including publication count, citation count, percentage of cited publications, self-citation ratio, field citation ratio (FCR), and relative citation ratio (RCR). In addition, the collaboration networks for each journal were analyzed in terms of the number of authors, co-authorship links, total co-authorships, and the number of co-authorship clusters. The scientific impact and academic prestige of the journals were assessed using the SCImago Journal Rank Indicator, Q Journal Classification, and H-index.
    Results: The Turkish Journal of Ophthalmology (TJO) outperformed the other journals across various metrics, including publication count, citation count, percentage of cited articles, and impact factors. The Beyoglu Eye Journal exhibited the second best performance. The TJO also exhibited the most extensive collaboration network and the highest FCR and RCR values, indicating its strong academic impact.
    Conclusion: The TJO is the leading ophthalmology journal in Türkiye, while Beyoglu Eye Journal demonstrates the second-best performance, both exhibiting high publication counts, citation metrics, and field-normalized indicators. Other Turkish ophthalmology journals demonstrate lower levels of academic impact, indicating that coordinated efforts are required to enhance their quality, visibility, and global recognition.
    Keywords:  Bibliometrics; Dimensions database; Ophthalmology journals in Türkiye; SCImago Journal and Country Rank; Tübitak/Ulakbim
    DOI:  https://doi.org/10.14744/bej.2025.15689
  6. Hum Vaccin Immunother. 2025 Dec;21(1): 2530288
      Bibliometric analysis has been employed to systematically evaluate the research landscape and emerging trends in ovarian cancer immunotherapy over the past decade (2014-2024). A bibliometric analysis of 3,100 publications (including reviews articles and articles) on immunotherapeutic interventions for ovarian malignancies was conducted using the Web of Science Core Collection (2014-2024). Temporal publication trends, institutional collaboration networks, and emerging research foci were systematically examined via CiteSpace software. A total of 3381 articles on ovarian cancer immunotherapy were initially identified, with 3100 records meeting the inclusion criteria for final analysis. The United States (n = 1,076) to become the major contributors of this field, with the University of Texas System (n = 131) being the most prolific institution. Among individual researchers, Odunsi, Kunle (n = 32) were the most extensively published authors. The most frequently cited reference was Matulonis UA (2019), with 235 citations. Co-citation cluster analysis revealed seven major research themes: expression, parp inhibitors, cancer immunotherapy, endometrial cancer, ovarian cancer, tumor associated antigens, chimeric antigen receptor. Parp inhibitors, tumor-associated antigens, and CAR-based therapies constituting critical themes for ovarian cancer research. Keyword burst detection identified emerging foci: dendritic cell, adoptive cell transfer, and regulatory T cell. These approaches offer promise for countering the TME characteristic of ovarian cancer, thereby enabling enhanced therapeutic efficacy. Prominent universities and developed nations form the finest alliances for research on immunotherapy for ovarian cancer. Three core research clusters are identified: dendritic cell-based therapies, adoptive immunotherapy, and tumor-infiltrating lymphocyte applications. These findings delineate the field's evolving trajectory and offer strategic directions for future investigations, emphasizing translational potential and multidisciplinary integration.
    Keywords:  CiteSpace; Immunotherapy; bibliometric analysis; knowledge mapping; ovarian cancer
    DOI:  https://doi.org/10.1080/21645515.2025.2530288
  7. Front Neurol. 2025 ;16 1605351
       Objectives: This study employs bibliometric analysis to investigate the current states and emerging trends in the field of sepsis associated encephalopathy biomarkers. It conducts a comparative analysis of the research contributions from different countries, institutions, journals and authors, thereby providing a valuable reference for future investigations in this field.
    Methods: All publications on sepsis associated encephalopathy biomarkers research were retrieved and extracted from the China National Knowledge Infrastructure Database and the Web of Science Core Collection on December 31st, 2024. Microsoft Office Excel was used to conduct quantitative analysis of related studies data. VOSviewer, CiteSpace and R package "bibliometrix" were used to conduct the bibliometric analysis.
    Results: This study included 248 articles from 36 countries, with China and the United States identified as the primary contributors. The number of publications concerning sepsis associated encephalopathy biomarkers has been progressively rising on an annual basis. Santa Catarina State University, University of Texas Health Science Center at Houston and University of Texas System are the primary research institutions. The largest number of publications appeared in Molecular Neurobiology. Critical Care Medicine is the most co-cited journal. These publications contributed by 1,234 authors among which Felipe Dal-pizzol, Tatiana Barichello and Fabricia Petronilho had published numerous articles and Felipe Dal-pizzol was the most frequently co-cited. "Neuron specific enolase," "protein" and "oxidative damage markers" are the primary keywords of emerging research hotspots.
    Conclusion: This is the first thorough bibliometric study to summarize the developments and trends of sepsis associated encephalopathy biomarkers research since the inception of the China National Knowledge Infrastructure Database and the Web of Science Core Collection. These findings identify recent research hotspots, which will provide a reference for scholars studying sepsis associated encephalopathy biomarkers in the future.
    Keywords:  CiteSpace; VOSviewer; bibliometric analysis; biomarkers; sepsis associated encephalopathy
    DOI:  https://doi.org/10.3389/fneur.2025.1605351
  8. Pediatr Discov. 2024 Mar;2(1): e49
      This study aimed to visualize the knowledge structure and research trends in neonatal sepsis research through bibliometric methods. Articles and reviews regarding neonatal sepsis from 2002 to 2022 were retrieved from the Web of Science Core Collection database. CiteSpace software was used to visualize the knowledge network of countries/regions, institutions, authors, journals, keywords, and references in this field. Altogether, 2314 publications were identified. During the study period, the number of publications increased yearly. The USA is the leading country in neonatal sepsis research. Duke University was the most prolific institution, with Pediatric Infectious Disease Journal and BASU S being the most prolific journal and author in the field, respectively. Pathogen, diagnosis, and management were the main topics of research, and future studies may concentrate on novel diagnostic biomarkers and judicious use of antibiotics. In summary, the results of our bibliometric analysis revealed views on the current situation and trends of neonatal sepsis research for the first time. This study may provide guidance for promoting research on neonatal sepsis.
    Keywords:  CiteSpace; bibliometric analysis; neonatal sepsis; research hotspot; research trends
    DOI:  https://doi.org/10.1002/pdi3.49
  9. Front Microbiol. 2025 ;16 1606351
       Background: Acinetobacter baumannii is a common hospital pathogen that poses a serious clinical challenge due to its rapidly increasing resistance to antibiotics. Phage therapy has been successfully used to treat antibiotic resistant A. baumannii infections. The aim of this study was to comprehensively assess the current status and trend of research on the application of phages in A. baumannii infections through bibliometric analysis.
    Methods: Studies on phages and A. baumannii infections were searched in the Web of Science Core Collection database and relevant articles were selected for inclusion in the study based on the inclusion criteria. Bibliometric and visual analysis of the included publications were performed using VOSviewer and CiteSpace software.
    Results: A total of 264 studies were included. There is an increasing trend in the number of publications per year from 2010 to 2024. China was the leading country with 35.98% of the total publications. Tzu Chi University and Lin, Nien-Tsung were the most influential institution and author, respectively. The journal with the highest H-index was Frontiers in Microbiology, and Viruses-Basel was the most prolific journal. Antimicrobial Agents and Chemotherapy was the most cited journal. Phages endolysin and phage therapy were found to be the widely researched aspects, biofilm, phage resistance and synergistic effect are recent research hotspots.
    Conclusion: In the last decade or so, this is the first bibliometric study that systematically describes the research hotspots and development trends on phages in A. baumannii infections. Research hotspots should be given more attention.
    Keywords:  Acinetobacter baumannii; bibliometric analysis; biofilm; phage resistance; phages therapy; synergistic effect
    DOI:  https://doi.org/10.3389/fmicb.2025.1606351
  10. J Indian Soc Periodontol. 2025 Jan-Feb;29(1):29(1): 6-13
      With partial edentulism prevalent among aging populations retaining natural teeth, understanding the relationship between removable partial dentures (RPDs) and abutment teeth periodontal health is crucial. To provide a bibliometric analysis of research trends on periodontal considerations of abutment teeth in RPDs, highlighting key publications, research clusters, and influential keywords from 1948 to 2024. An advanced search of Elsevier's Scopus database was conducted, extracting data such as publication titles, years, citations, journals, countries, and keywords. Bibliometric analysis and network visualizations were generated using Biblioshiny and VOSviewer software. The annual growth rate of studies on periodontal consideration of abutment teeth in RPDs was 2.39%. The Journal of Prosthetic Dentistry had the most publications and citations, while the Journal of Periodontology held the highest average and normalized citations, signifying its impact. Highly cited articles were predominantly clinical studies. Coauthorship analysis showed that the United States, Japan, and Germany had the highest research output, while Sweden, Switzerland, and Germany led in average citations per document, highlighting Europe's strong influence in this research area. The VOSviewer map identified nine distinct research clusters covering various aspects of prosthodontics, including material innovations, prosthetic design, patient quality of life, clinical assessments, complications, and advanced technologies. High-impact terms included "longitudinal study," "crowns," and "Periotest value" based on average citations, while "PEEK" leads in average normalized citations, indicating its growing influence. Periodontal considerations are central to research on abutment teeth in RPDs, highlighting the need for comprehensive, long-term evaluations of periodontal health and abutment tooth stability.
    Keywords:  Abutment teeth; bibliometric analysis; periodontal; removable partial denture
    DOI:  https://doi.org/10.4103/jisp.jisp_437_24
  11. Front Psychol. 2025 ;16 1541092
       Objective: This study aimed to conduct a bibliometric analysis of research literature on AI-assisted psychological interventions for stroke survivors published from 2000 to 2024, using CiteSpace and VOSviewer to examine research collaboration networks, knowledge structures, and developmental trends.
    Methods: Literature data was sourced from the Web of Science Core Collection database (WoSCC). A total of 450 relevant articles, published between 1 January 2000 and 31 October 2024, were included. CiteSpace and VOSviewer were employed to analyze the literature from dimensions including authorship, country of origin, institutions, journals, references, and keywords.
    Results: Annual publication output has steadily increased, reaching a peak in 2022 (72 articles), followed by 68 articles in 2023 and 69 articles in 2024. Calabro Rocco Salvatore emerged as the most productive author (9 publications). The United States led in research output (87 articles) and centrality (0.51), with McGill University being the leading institution (10 articles). "Journal of NeuroEngineering and Rehabilitation" was the most productive journal (24 articles), while "Stroke" was the most co-cited journal (347 times). Recent research trends focused on ischemic stroke (strength = 3.09), anxiety (strength = 2.72), cognitive impairment (strength = 2.67), and meta-analysis (strength = 2.58), reflecting a shift toward integrated assessment and intervention strategies.
    Conclusion: This bibliometric analysis reveals a significant evolution in research on AI-assisted psychological interventions for stroke survivors, shifting from single technology applications to integrated services encompassing assessment, monitoring and intervention. Future research should continue to strengthen empirical studies while enhancing interdisciplinary collaboration to improve the quality of psychological healthcare services.
    Keywords:  CiteSpace; VOSviewer; artificial intelligence; bibliometric analysis; psychological intervention; stroke survivors
    DOI:  https://doi.org/10.3389/fpsyg.2025.1541092
  12. Front Neurol. 2025 ;16 1505574
       Background: Narcolepsy is a rare neurological cause of chronic sleepiness. This study aimed to better understand global narcolepsy through bibliometric analysis.
    Methods: Articles and reviews on narcolepsy were sourced from the Web of Science Core Collection. A bibliometric analysis was performed using Microsoft Excel, Python, CiteSpace, VOSviewer, R (bibliometrix), and the Online Analysis Platform of Literature Metrology to assess publication outputs, countries, institutions, authors, journals, co-cited references, and keywords.
    Results: The analysis included 5,215 publications, with citations significantly increasing from 1996 to 2024. The USA led in publications, while the top institutions were Stanford University, INSERM, and Université de Montpellier. Key authors like Professors Plazzi G, Mignot E, and Dauvilliers Y greatly contributed to the field through numerous publications and high citation rates. Sleep published the most articles, followed by Sleep Medicine. Keyword analysis indicated a shift toward molecular mechanisms, comorbidities, and diagnosis. Recent interest has surged in medications for excessive daytime sleepiness, such as "Pitolisant", "Modafinil" and "Sodium Oxybate" along with the relationship between narcolepsy and COVID-19.
    Conclusion: "Pitolisant," "Modafinil," and "Sodium Oxybate" have gained prominence in narcolepsy treatment. This study also highlights common comorbidities linked to narcolepsy, including "obstructive sleep apnea", "epilepsy" and "atrial fibrillation" driving researchers to explore these conditions to improve the quality of life for affected individuals. However, the interactions between key neurotransmitters in narcolepsy are still unclear, and challenges remain regarding factors that complicate drug therapy efficacy, necessitating further investigation.
    Keywords:  bibliometric analysis; comorbidities; molecular mechanisms; narcolepsy; treatment
    DOI:  https://doi.org/10.3389/fneur.2025.1505574
  13. Medicine (Baltimore). 2025 Jul 04. 104(27): e43204
       OBJECTIVE: This study aims to evaluate the growth and evolving focus of college sports management (CSM) research, identifying key contributors and thematic trends within the field.
    METHODS: A bibliometric approach was used, analyzing data from VOSviewer, and the Web of Science (WoS), Scopus and EBSCOhost to assess publication patterns, co-citation networks, and keyword co-occurrence, highlighting influential authors, institutions, and research themes.
    RESULTS: Our study findings show an increase in CSM publications, with significant contributions from the USA, England, and Australia. Co-citation analysis highlights foundational theories, while keyword analysis identifies thematic clusters in management, sports, exercise, and performance. Emerging research focuses include "impact," "performance," "injuries," "concussions," and "risk."
    CONCLUSIONS: This study suggests a need for localized CSM strategies and integration of technologies like artificial intelligence and Internet of Things to drive advancements. Future studies should incorporate additional databases for a broader view of CSM trends. This study underscores the importance of adaptive strategies to meet the dynamic needs of the CSM field globally.
    Keywords:  VOSviewer; bibliometric analysis; college sports management; visualizing research
    DOI:  https://doi.org/10.1097/MD.0000000000043204
  14. Front Public Health. 2025 ;13 1598482
       Background: Medication literacy (ML) has emerged as a critical global public health concern, garnering growing scholarly attention over the past two decades. To delineate major research domains, identify evolving trends, and inform future research priorities, we conducted a scientometric analysis of the scientific literature on ML.
    Methods: A systematic search was performed to retrieve publications on ML from the Web of Science Core Collection, covering the period from 2003 to 2024. Scientometric analyses were executed using CiteSpace and VOSviewer to visualize and evaluate collaborative networks, including co-citation references, co-occurring keywords, and contributions by countries, institutions, authors, and journals.
    Results: The analysis incorporated 1,968 eligible publications. A rapidly growing trend in research interest in ML was observed, with an average annual growth rate of 46.1% in publications between 2003 and 2022. Three major research trends were identified: relationship between ML and medication adherence, the development of ML-specific assessment tools, and investigation of psychosocial factors associated with ML. The United States of America, Northwestern University, Davis Tc, and Patient Education and Counseling were identified as the most cited and influential entities within this field, representing the leading country, institution, author, and journal, respectively.
    Conclusion: Scientometric analysis provides invaluable insights to clinicians and researchers involved in ML research by identifying leading contributors, intellectual bases and research trends. ML is evolving from unidimensional analysis to multidisciplinary exploration of dynamic mechanisms. Future research on ML is facing significant challenges, including the exploration of adherence mechanisms, validation of digital assessment tools, and the moderating effect model of socio-psychological factors on ML.
    Keywords:  CiteSpace; VOSviewer; bibliometric; medication literacy; scientometric
    DOI:  https://doi.org/10.3389/fpubh.2025.1598482
  15. ILIVER. 2024 Mar;3(1): 100075
       Background and aims: Through visual analysis of related literature, the main research direction and hot spots of liver sinusoidal endothelial cells (LSECs) in recent 24 years were explored.
    Methods: This study used bibliometric analysis with CiteSpace, VOSviewer, Biblioshiny and online analytic tool bibliometric.com to provide a quantitative analysis, hot spot mining, and commentary of articles published in the field of LSECs research. The relevant literature in the Web of Science Core Collection (WOSCC) was searched from 2000 to 2023. The publications with topics or titles or keywords containing LSECs were included into this study. The countries, organizations, journals, authors, and keywords of the publications were summarized and analyzed.
    Results: This study included 3,747 publications from 14,132 authors belonging to 389 institutions in 61 countries/regions and published in 150 journals, with 156,309 citations. The United States contributed most (1,150) to the publications. The most productive institution was the University of Sydney. Hepatology accounts for the most output (293, 7.8​%), European authors had a widespread cooperation. The most productive author was Adam DH with 68 papers. Immunological function of LSECs is research hot spot.
    Conclusion: This study highlights key trends based on a large dataset of the most influential publications about LSECs research over a 24-year period. It provides important clues and ideas for researchers focusing in this area and facilitates future liver disease mechanism, understanding, and treatment.
    Keywords:  Bibliometrics; CiteSpace; Liver sinusoidal endothelial cells; VOSviewer
    DOI:  https://doi.org/10.1016/j.iliver.2023.11.002
  16. J Multidiscip Healthc. 2025 ;18 3849-3850
      [This corrects the article DOI: 10.2147/JMDH.S476838.].
    DOI:  https://doi.org/10.2147/JMDH.S549114
  17. Front Med (Lausanne). 2025 ;12 1596228
       Background: Lung cancer is the most common cancer and the leading cause of cancer-related death worldwide. In pulmonary fibrosis (PF), the incidence of lung cancer is elevated, and its prognosis is worse compared to the general population. With the development of related research, the relationship between lung cancer and pulmonary fibrosis has received close attention. However, comprehensive and objective reports on this topic remain scarce. Therefore, this study aims to identify research hotspots and visualize evolving trends and collaboration networks in the field of pulmonary fibrosis and lung cancer using bibliometric and knowledge mapping tools.
    Methods: Articles in the field of pulmonary fibrosis and lung cancer were retrieved using the Web of Science core collection subject search, and bibliometric analysis was performed in CiteSpace, VOSviewer, ChiPlot (https://www.chiplot.online/) and Bibliometrix (R-Tool of R-Studio).
    Results: This bibliometric analysis included 1,830 publications from 2000 to 2024, showing a steady increase over time. Collaborative network analysis identifies Japan, the United States, and China as the most influential countries, contributing the highest publications and citations. Respiratory Research is the leading journal. Bade BC is a key author, with Lung Cancer 2020: Epidemiology, Etiology, and Prevention as the most cited work. Literature and keyword analyses indicate a primary focus on diagnosis and survival, with recent shifts toward gene regulation and pulmonary inflammation. Emerging research highlights epithelial-mesenchymal transition (EMT) and chronic inflammation in lung cancer development among IPF patients. Notably, studies on immune checkpoint inhibitors (e.g., PD-1/PD-L1) have surged, reflecting a growing interest in immunotherapy.
    Conclusion: This study is the first to employ bibliometric methods to visualize research trends and frontiers in pulmonary fibrosis and lung cancer. Our analysis reveals a shift from early studies on diagnosis and prognosis toward a growing focus on molecular mechanisms and immunotherapy. These findings offer valuable insights into emerging research directions and may serve as a reference for researchers seeking to identify key topics and potential collaborators.
    Keywords:  CiteSpace; VOSviewer; lung cancer; pulmonary fibrosis; visual analysis
    DOI:  https://doi.org/10.3389/fmed.2025.1596228
  18. Medicine (Baltimore). 2025 Jul 04. 104(27): e42956
       OBJECTIVE: This study aimed to perform a bibliometric analysis to explore the current state and emerging trends of XR (extended reality: virtual reality, augmented reality, mixed reality) technology applications in orthopedics.
    METHOD: Scholarly publications from January 1, 2000, to June 20, 2023, were retrieved from the Web of Science and analyzed using bibliometric tools such as VOSviewer, CiteSpace, and R.
    RESULTS: A total of 551 publications from 234 journals, authored by 2624 researchers across 1613 institutions in 53 countries/regions, were included. The United States led in publication volume (128, 23.79%), with Johns Hopkins University as the most productive institution (19, 3.53%). Edstrom, Erik was the most prolific author (15, 2.79%), and the International Journal of Computer Assisted Radiology and Surgery had the highest publication count (36, 6.69%). Frequently used keywords included "augmented reality," "surgical navigation," and "navigation," while research hotspots focused on topics like "total knee arthroplasty," "mixed reality," and "osteoarthritis."
    CONCLUSION: This study offers a comprehensive overview of research trends and advancements in XR technology applications within orthopedics, highlighting collaborative efforts among authors, institutions, and countries, and providing insights for future research directions.
    Keywords:  XR; augmented reality; extended reality; minimally invasive surgery; mixed reality; virtual reality
    DOI:  https://doi.org/10.1097/MD.0000000000042956
  19. Front Med (Lausanne). 2025 ;12 1601806
       Background: Intervertebral disc degeneration (IVDD) is a major global cause of disability, and mesenchymal stem cell (MSC) therapy offers a promising regenerative solution by targeting the root causes of degeneration, unlike conventional symptom-focused treatments. This bibliometric analysis explores trends and emerging research areas in MSC applications for IVDD.
    Methods: A comprehensive literature search was conducted in the Web of Science Core Collection database, covering publications from 2000 to 2024. Bibliometric and visualized analysis was performed using VOSviewers, CiteSpace and the R package "Bibliometrix."
    Results: This bibliometric analysis reviewed 931 articles, revealing an overall upward trend in publication activity. Leading authors included Sakai Daisuke, Grad Sibylle, and Alini Mauro. China and the USA led in publication volume and citation counts, while the United Kingdom achieved the highest average citations per publication. The University of Pennsylvania and Zhejiang University were the most productive institutions. Key journals included Biomaterials, Spine, and Tissue Engineering Part A. Earlier core keywords primarily focused on foundational concepts such as "gene expression," "articular cartilage," "anulus fibrosus" and "extracellular matrix." Recent keyword bursts include "activation," "autophagy," "extracellular vesicles," "apoptosis," "exosome," and "oxidative stress."
    Conclusion: This bibliometric analysis revealed key research focuses on foundational biological mechanisms, translational applications, and addressing specific challenges in the use of MSC for IVDD. Future research is likely to focus on optimizing MSC functionality, developing cell-free therapies such as extracellular vesicles, and targeting the molecular mechanisms involved in disc degeneration and regeneration.
    Keywords:  CiteSpace; VOSviewer; bibliometric analysis; intervertebral disc degeneration; mesenchymal stem cells; regenerative medicine
    DOI:  https://doi.org/10.3389/fmed.2025.1601806
  20. Front Med (Lausanne). 2025 ;12 1525526
       Objective: This study aimed to delineate the current trends and hotspots in autophagy research related to metabolic syndrome (MetS) and metabolic dysfunction-associated steatotic liver disease (MASLD), with the aim of guiding future investigations in this area.
    Methods: This study extracted research on autophagy in MetS and MASLD from the Web of Science Core Collection (WoSCC) database. Review articles were systematically excluded to focus on original research contributions. A bibliometric analysis and visualization were conducted using VOSviewer 1.6.20, CiteSpace 6.3.R1, and R 4.3.3.
    Results: The study included 1,114 articles from 1,220 institutions across 42 countries/regions, demonstrating a significant increase in research output from 2009 to 2024. China led with 506 publications, followed by the USA and Korea. The Egyptian Knowledge Bank constitutes a consortium of institutions operating within the national research framework, with one institution designated as the primary publishing entity. Notably, the journal Nature has emerged as the most frequently cited publication. Singh Rajat received the highest number of citations (3,610), while Marycz Krzysztof was the most prolific author. The most cited article, published in 2009, was titled "Autophagy regulates lipid metabolism." Keyword trends have shifted from earlier topics such as "phosphorylation" and "gene-expression" to more recent terms like "lipid accumulation" and "mitophagy." Burst keyword analysis indicated that "liver fibrosis," "modulation," "gut microbiota," and "lipotoxicity" have emerged as significant topics.
    Conclusions: This study has elucidated the protective role of autophagy in MASLD and MetS. Future research is anticipated to concentrate on the activation of autophagy in the context of natural product drug discovery, the exploration of underlying molecular mechanisms, the regulation of fatty acid metabolism, and the development of functional nutritional supplements, among other relevant areas.
    Keywords:  CiteSpace; VOSviewer; autophagy; bibliometric analysis; metabolic syndrome; non-alcoholic fatty liver disease
    DOI:  https://doi.org/10.3389/fmed.2025.1525526
  21. Front Psychiatry. 2025 ;16 1621830
       Background: Patients suffering from depression frequently encounter extended periods of low moods and lack of enjoyment or enthusiasm for activities. It leads to suicidal thoughts and presents a potential hazard to their safety. Nowadays, there has been significant progress in researching the effectiveness and safety of esketamine in treating depression. Hence, this paper employs bibliometric analysis to investigate the evolution and future research trajectories of this domain.
    Methods: We utilize Excel, VOSviewer, and CiteSpace software to generate bibliometric network visualizations to analyze, construct, and quantitatively evaluate pertinent literature, which facilitates a lucid and intuitive presentation of the trends and frontiers in this research domain.
    Results: Annual publications increased from 2015 to 2024, totaling 925 articles, with 286 studies published in 2024. The USA published the most papers (n=308), followed by China (n=260) and Canada (n=114). Three of the top journals were Journal of Affective Disorders (n=56,IF=4.90), Frontiers in Psychiatry (n=38,IF=5.44), and International Journal of Neuropsychopharmacology (n=21,IF=4.50). The most published authors were McIntyre, Roger S (n=52), followed by Hashimoto, Kenji (n=49), Rosenblat, Joshua D (n=41). The keywords that have been relevant to the topic for the last decade are "treatment-resistant depression", "efficacy", "antidepressant" and "suicidal ideation".
    Conclusions: This bibliometric analysis showed a significant increase in research on the use of esketamine in the treatment of depression. The main focus of current research is still the assessment of long-term use safety. In addition, the huge difference in research resources between developed countries and low- and middle-income countries remains an unresolved issue.
    Keywords:  antidepressant; bibliometric analysis; depression; esketamine; research trend
    DOI:  https://doi.org/10.3389/fpsyt.2025.1621830
  22. Nurs Crit Care. 2025 Jul;30(4): e70112
       BACKGROUND: Hospital administrators apply information technology to improve healthcare quality; however, a comprehensive bibliometric analysis remains limited.
    AIM: To explore the research topic, key contributors and development trends of clinical decision support systems (CDSS) in intensive care units (ICUs).
    STUDY DESIGN: Between January 1, 2014, and December 31, 2024, a bibliometric analysis was undertaken. CiteSpace software was used to conduct a visual analysis of literature retrieved from the Web of Science Core Collection database. Publishing countries, institutions, authors, cited journals and keywords were reported.
    RESULTS: A total of 817 articles were included in the final analysis. The annual publication volume showed an overall upward trend. The United States was the country with the highest number of publications (338 articles, 41.37%), and the University of Pittsburgh was the most prolific institution (29 articles, 3.55%). Herasevich, Vitaly from Mayo Clinic, Dept Anesthesiol, was the most prolific author (8 articles, 0.98%). Critical Care Medicine was the most cited journal (n = 421). Research hotspots primarily focused on the integration of CDSS with clinical practice, intelligent decision support-driven precision ICU care and the effectiveness of CDSS in managing ICU patients. Research trends centred on prediction, respiratory distress syndrome and artificial intelligence.
    CONCLUSIONS: This study highlights key research areas in CDSS applications in ICUs, focusing on clinical integration, precision care and patient management, offering insights for improving healthcare quality.
    RELEVANCE TO CLINICAL PRACTICE: The findings from this bibliometric analysis can assist ICU nurses in advancing research on integrating CDSS into ICU practices, developing intelligent decision support tools and addressing gaps in precision care, prediction models and AI-driven solutions to enhance patient outcomes and optimise critical care management.
    Keywords:  application; bibliometric analysis; clinical decision support systems; intensive care units; research
    DOI:  https://doi.org/10.1111/nicc.70112
  23. Nanomedicine (Lond). 2025 Jul;20(14): 1693-1711
       INTRODUCTION: Inflammatory bowel disease (IBD) is a chronic and nonspecific gastrointestinal disorder, imposing significant physical, emotional, and economic burdens on patients. In recent years, nanomaterials have shown great potential in the management of IBD. This study employs bibliometric analysis to map global research trends and intellectual landscapes in nanomaterials application for IBD.
    METHOD: A comprehensive search was conducted on the Web of Science Core Collection database for studies pertaining to nanomaterials and IBD. Bibliometric and visual analysis of the included publications were facilitated by the utilization of Bibliometrix R, VOSviewer and CiteSpace software.
    RESULT: A total of 879 studies were included. China, the United States, and Germany are the leading countries in this field. Georgia State University emerged as the most productive institution, while Didier Merlin and Zhang Mingzhen were identified as influential core authors. International Journal of Pharmaceutics was the most productive journal, and Journal of Controlled Release was the most cited journal. Keyword analysis highlighted "drug delivery," "gut microbiota," "reactive oxygen species" and "anti-inflammation" as dominant research frontiers, with burst keywords such as "polymeric nanoparticles" and "gut microbiotasignaling emerging trends.
    CONCLUSION: These findings underscore nanomaterials' transformative potential in IBD management, particularly in targeted therapies and microbiome modulation, while emphasizing the need for interdisciplinary collaboration to address clinical translation challenges.
    Keywords:  Drug Delivery Systems; Inflammatory bowel disease; bibliometric analysis; nanomaterials; research trend
    DOI:  https://doi.org/10.1080/17435889.2025.2527594
  24. Front Oncol. 2025 ;15 1571870
       Background: Protein palmitoylation is a dynamic and reversible lipid modification that has attracted increasing attention in cancer research in recent years. Palmitoylation involves the covalent attachment of palmitic acid (C16) to cysteine residues, altering the protein's hydrophobicity and thereby affecting its membrane localization, stability, and functional activity. Recently, palmitoylation has been closely associated with the development and progression of various cancers, making it a key factor in cancer biology research.
    Methods: This study conducted a systematic bibliometric analysis using the Web of Science Core Collection (WoSCC) as the data source. A total of 685 papers published between January 1, 2004, and December 31, 2024, on the relationship between protein palmitoylation and cancer were selected. Information such as article titles, abstracts, and keywords was extracted to analyze publication trends, research hotspots, and collaboration networks among authors and institutions, thus assessing the dynamics of research in this field.
    Results: The analysis revealed that from 2004 to 2024, a total of 685 papers were published on the relationship between protein palmitoylation and cancer, with a significant increase in publications after 2020. The United States and China are the leading countries in this field, with institutions like Harvard University and the Chinese Academy of Sciences making substantial contributions. Research hotspots have shifted from early mechanistic studies to cancer-specific applications, particularly in areas such as tumor immune evasion, metabolic reprogramming, and therapeutic strategies, where significant progress has been made.
    Conclusion: Future efforts should concentrate on three primary directions: constructing high-resolution pan-cancer palmitoylation site maps to unveil subtype-specific modification patterns; developing subtype-selective inhibitors targeting the ZDHHC enzyme family to overcome the toxicity limitations of current broad-spectrum inhibitors; and establishing international research alliances to integrate China's high productivity with the United States' translational expertise, thereby bridging regional disparities between basic research and clinical innovation, ultimately advancing palmitoylation regulatory networks toward precision therapeutic strategies.
    Keywords:  bibliometrics; cancer; palmitoylation; research frontiers; visualization analysis
    DOI:  https://doi.org/10.3389/fonc.2025.1571870
  25. Medicine (Baltimore). 2025 Jul 04. 104(27): e43180
       OBJECTIVE: This study analyzes the research hotspots and future directions of frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis.
    METHODS: Relevant literature was searched using the Web of Science database and analyzed using econometric tools such as CiteSpace and VOSviewer.
    RESULTS: A total of 145 articles were included in this study, involving 317 research institutions in 31 countries and regions. Acta Neuropathologica is a prominent journal in terms of issuance and influence, and countries such as the United States and Japan, as well as institutions such as the University of Pennsylvania, occupy an important position in the research. The keywords cover various aspects such as disease characteristics and gene mutations; highly-cited literature focuses on TDP-43 protein and C9orf72 gene mutations. Research hotspots include TDP-43 protein disease-driven pathomechanisms, RNA-related studies, clinical manifestations of the disease and genetic studies, etc. In recent years, research focus has shifted to RNA, C9orf72 gene and so on.
    CONCLUSION: To our knowledge, this study is the first econometric evaluation of the FTLD-ALS literature, and although there are limitations such as relying on the number of documents and citation relationships, and a single source of data, it provides a valuable reference for research in this field and helps to promote subsequent research.
    Keywords:  amyotrophic lateral sclerosis; bibliometric analysis; frontotemporal lobar degeneration; future research direction; research hotspots
    DOI:  https://doi.org/10.1097/MD.0000000000043180
  26. Naunyn Schmiedebergs Arch Pharmacol. 2025 Jul 10.
       BACKGROUND: The prevalence of Alzheimer's disease is steadily increasing, and Aducanumab has garnered significant attention as a treatment since 2021. There is a growing body of research on Aducanumab and its relationship with Alzheimer's disease; however, there is currently a lack of bibliometric analysis regarding the use of Aducanumab in the treatment of Alzheimer's disease.
    OBJECTIVE: This study employs bibliometric methods to analyze the current research landscape and hotspots surrounding Alzheimer's disease and Aducanumab, providing a reference for subsequent investigations in this field and the promotion of Aducanumab as a treatment for Alzheimer's disease.
    METHODS: This study retrieved articles related to Alzheimer's disease and Aducanumab from the WOS core database, covering the period from the establishment of the database until Dec 31, 2024. After a rigorous selection process, analyses were conducted using GraphPad Prism 10, VOSviewer, and CiteSpace to obtain insights into publication and citation metrics, collaboration networks among countries, institutions, and authors, as well as clustering analysis of reference papers and keywords.
    RESULTS: The number of articles regarding Aducanumab treatment for Alzheimer's disease has been increasing annually, with a notable surge occurring after 2021. The three countries with the highest publication output are the United States, the United Kingdom, and China. The leading institutions in terms of publication volume are Biogen, Harvard Medical School, and the University of California, San Francisco. The top three authors contributing to this body of work are Poul F. Høilund-Carlsen, Abass Alavi, and Mona-Elisabeth Revheim. The journals with the highest publication rates include Alzheimer's & Dementia, the International Journal of Molecular Sciences, and the Journal of Alzheimer's Disease. The most cited article is "Lecanemab in Early Alzheimer's Disease," authored by van Dyck CH et al., published in 2023 in the New England Journal of Medicine. The ten most frequently occurring keywords are Alzheimer's disease, Aducanumab, dementia, amyloid-beta, immunotherapy, tau, a-beta, mouse model, amyloid, and mild cognitive impairment. The keyword and cluster "pharmacokinetics" currently represent a research hotspot in this field.
    CONCLUSION: This study employs bibliometric methods to reveal the publication trends related to Aducanumab in the context of Alzheimer's disease, examining collaborations among countries, regions, and authors, as well as recent research hotspots. It provides objective data that serves as a reference for scientific research and clinical practice concerning Aducanumab treatment for Alzheimer's disease.
    Keywords:  Aducanumab; Alzheimer's disease; Bibliometric analysis; Hotspots; Keywords; Publication
    DOI:  https://doi.org/10.1007/s00210-025-04448-6
  27. Front Microbiol. 2025 ;16 1601245
       Background: Human immunodeficiency virus (HIV) infection remains a significant global health challenge, with Kaposi's sarcoma (KS) being one of the most common AIDS-defining cancers. This study aimed to investigate the development of HIV and KS (HIV-KS) research through bibliometric analysis and to assess the current literature to advance the field.
    Methods: We gathered 1,568 publications on HIV-KS from the Web of Science Core Collection and analyzed them to visualize the data, identifying future directions and emerging trends by CiteSpace software. Betweenness centrality, count, and burst value were used as metrics.
    Results: The number of publications on HIV-KS fluctuated in the included literature. The most important contributions from countries and institutions were the United States and the National Institutes of Health (NIH) - USA, respectively. Denise Whitby was the most prolific author, while Yuan Chang had the highest cocitation count. The most commonly cited article is "Kaposi sarcoma (2019)." The hotspots in this field are "basic mechanism," "Kaposi's sarcoma-associated herpesvirus-related disease," and "treatment measures." The present research direction of HIV-KS is focused on exploring the emerging prevalence, diagnostic methods, and therapeutics.
    Conclusion: This study outlines the current landscape and emerging hotspots of HIV-KS research, offering insights into thematic evolution and collaboration patterns. By identifying key research priorities and structural gaps, the findings can inform future scientific directions, guide resource allocation, and support more context-sensitive strategies for the diagnosis, treatment, and prevention of HIV-KS.
    Keywords:  CiteSpace; HIV; Kaposi’s sarcoma; bibliometric analysis; visualized analysis
    DOI:  https://doi.org/10.3389/fmicb.2025.1601245
  28. J Clin Exp Dent. 2025 Jun;17(6): e732-e741
       Background: This study aims to comprehensively appraise the bibliometric features of articles evaluating the utilization of gelatin methacryloyl (GelMA) in dentistry by conducting a bibliographic search on the Web of Science databases until January 2025.
    Material and Methods: The following data were gathered: number and density of citations; authors; year, journal of publication and impact factor; study design and theme; keywords; institution and country of origin. The collaborative network was identified with the VOSviewer software and used to generate collaborative network maps for authors and keywords.
    Results: A total of 133 articles reporting the use of GelMA in dentistry were included. The articles were published between 2014 and 2025, and the most prevalent journals were Dental Materials (10,17% and 276 citations) and Acta Biomaterialia (10,1% and 208 citations) The most frequent study designs and themes were laboratory-based in vitro studies (58,6%) and endodontics (37,6%), respectively. Bottino MC (9%; 464 citations) and Dubey N (4,5%; 345 citations) were the most prominent authors in the list. Most articles originated from China (52,6%) and the United States (29,3%). University of Michigan (12,8%) and Sichuan University (6,7%), located in the USA and China, respectively, were the institutions with the most articles. There was a strong negative correlation between the number of citations and the year of publication, with the most recent articles being the most cited.
    Conclusions: Global articles related to the use of GelMA in dentistry were published mainly in China, with laboratory-based studies conducted in vitro addressing topics related to the use of GelMA in endodontics. Key words:Gelatin Methacryloyl, Dental Materials, Bibliometric Analysis.
    DOI:  https://doi.org/10.4317/jced.62741
  29. Zhonghua Kou Qiang Yi Xue Za Zhi. 2025 Jul 02. 60(7): 723-730
      Objective: To analyze research trends, hotspots, and international collaboration in temporomandibular disorders (TMD) from 2010 to 2024 using bibliometric methods. Methods: A total of 4 368 articles were retrieved from PubMed (January 2010 to December 2024) using the search strategy temporomandibular disorders[MeSH Terms] OR temporomandibular joint disorders[Title/Abstract]. The R package"bibliometrix" was employed to analyze publication statistics, author collaboration networks, and keyword co-occurrence. Results: The annual publication volume in the TMD field exhibited a 3.4-fold increase from 2010 to 2024, with an average annual output of 291.2 articles. MANFREDINI DANIELE was identified as the most prolific author (74 articles). The Journal of Oral Rehabilitation ranked first in terms of publication quantity (454 articles). The University of São Paulo (Brazil) emerged as the leading contributor, with Sichuan University (China) ranking second globally. Research hotspots predominantly focused on the DC/TMD diagnostic criteria and pain mechanisms. Analysis of international collaboration networks revealed that core authors (e.g., Lobbezoo F, Manfredini D) have driven advancements in the field through multidisciplinary collaboration (dentistry+psychology+medical imaging). The high-frequency occurrence of the imaging keyword "magnetic resonance imaging (MRI)"underscores its pivotal role in diagnosing disc displacement. Chinese institutions (Sichuan University, Peking University) ranked second globally in research output; however, interdisciplinary international collaboration remained limited, with multiple-country publications (MCP) accounting for only 13.0%. Conclusions: TMD research demonstrates interdisciplinary integration, necessitating future emphasis on Asian population studies and innovative diagnostic/therapeutic technologies.
    DOI:  https://doi.org/10.3760/cma.j.cn112144-20250313-00079
  30. Braz Oral Res. 2025 ;pii: S1806-83242025000102000. [Epub ahead of print]39 e067
      The aim of this study was to analyze the trends and main characteristics of articles on resin infiltration (RI) in dentistry. The search was carried out in August 2023 on Web of Science. Two researchers selected the articles and excluded conference articles. The following data were extracted from the selected articles: citations, year and journal of publication, study design and theme, authorship and institutions, keywords, country and continent. Collaborative networks were generated using the software Vosviewer. Dimensions were consulted to measure altmetric data. Correlation between data was determined by the Sperman's test. A total of 351 articles were included. The number of citations ranged from 0 to 230. The articles were published between 2007 and 2023. The most prominent journal was Journal of Dentistry (n = 36). The majority were laboratory studies (n = 171) evaluating the performance of RI to mask white spot lesions (n = 248), mainly due to caries (n = 256). The country with the most articles was Brazil (n = 51), however the biggest highlight was Europe (n = 141). The most prominent author was Meyer-Luckel H (n = 33). Vosviewer indicated strong collaborations between authors. According to Dimensions, most citations were from Mendeley followed by X users. This study identified an emerging trend in research on RI in dentistry. Based on this review, most research interest in RI was from Europe, addressing the use of RI to arrest and mask white spot lesions. It is concluded that more intervention studies are needed and that Africa and Oceania have a low publication rate.
    DOI:  https://doi.org/10.1590/1807-3107bor-2025.vol39.067
  31. J Oral Pathol Med. 2025 Jul 08.
       BACKGROUND: In recent years, noteworthy connections have been discovered between human wellness and microbiota. This study aims to outline the hotspots and trends in the links between the oral microbiome and cancer over the past 10 years from a bibliometric perspective.
    METHODS: Reports on original research and literature reviews on the relationship between the oral microbiome and cancer from 2014 to 2024 were retrieved from the Web of Science Core Collection and PubMed databases. CiteSpace and VOSviewer were utilized to display the research patterns.
    RESULTS: A bibliometric analysis was conducted on 4638 relevant publications, of which 3450 research articles and 1188 reviews were examined. China and the United States have contributed greatly to the research on the relationship between the oral microbiota and cancer, most of which were published in Frontiers in Microbiology, Frontiers in Cellular and Infection Microbiology, and International Journal of Molecular Sciences. The Chinese Academy of Sciences (107), Sichuan University (81), and Zhejiang University (79) are the most productive institutions. Zhou Xuedong, Hao Zhang, and Christian C. Abnet are the most recognized authors. Keyword co-occurrence revealed that the terms microbiome, oral microbiota, oral cancer, inflammatory diseases, probiotics, and dysbiosis are research hotspots in the past 10 years.
    CONCLUSIONS: The knowledge map provides a helpful visual representation of the main relevant topics in research conducted in the last 10 years on the relationship between the oral microbiome and cancer. The findings imply that oral squamous cell carcinoma, F. nucleatum, biomarkers, dysbiosis, and cancer treatment therapies have become popular topics in recent years.
    Keywords:  PubMed; bibliometrics; biomarkers; microbiota; mouth
    DOI:  https://doi.org/10.1111/jop.70000
  32. J Ayurveda Integr Med. 2025 Jul 08. pii: S0975-9476(25)00039-7. [Epub ahead of print]16(4): 101163
       BACKGROUND: Yoga has emerged as a widely recognized intervention for managing stress, with growing interest in its effectiveness across various populations. Despite expanding research, there remains a need for comprehensive analysis of trends within the literature to guide future studies and clinical applications.
    OBJECTIVE: This study aimed to analyze bibliometric trends in research on yoga for stress management, providing insights into publication patterns, key contributors, and evolving research directions in this field.
    METHODS: The experimental studies related application of yoga for stress management were searched from 2000 to 2024 on Scopus database. The search criteria were refined to include publications on yoga related to stress, with a focus exclusively on articles published in English. Quantitative data analysis was conducted using bibliometric tools, with visualizations created using VOSviewer.
    RESULTS: The analysis of 1025 articles revealed a significant increase in publications over 24 years, especially in the past four years. The International Journal of Yoga Therapy and the Journal of Alternative and Complementary Medicine were leading journals in this field. The United States and India were identified as primary contributors, with Khalsa SBS and Nagendra HR being the most prolific authors. Randomized controlled trials, meta-analyses, and systematic reviews emerged as predominant study types.
    CONCLUSION: This comprehensive bibliometric analysis highlights the growth of yoga and stress management research, emphasizing randomized controlled trials and evidence-based practices. Future studies should explore yoga's impact on diverse populations by age, occupation, and culture to clarify its universal applicability, advancing research and clinical applications.
    Keywords:  Bibliometrics; Evidence-based therapy; Randomized controlled trials; Scientometric analysis; Stress; Yoga
    DOI:  https://doi.org/10.1016/j.jaim.2025.101163
  33. Front Oncol. 2025 ;15 1570532
       Introduction: Tumor metabolic reprogramming refers to the alteration of metabolic pathways and patterns by tumor cells to adapt to various environmental conditions and energy demands, thereby playing a pivotal role in tumor progression. Targeting tumor metabolism has been shown to exert anti-tumor effects and improve the efficacy of conventional cancer therapies. As a result, tumor metabolic reprogramming has become a research area of considerable clinical value and potential, warranting comprehensive investigation.
    Methods: This bibliometric analysis was conducted to systematically summarize the research status, hotspots, and future trends in the field of tumor metabolic reprogramming. Relevant publications from January 1, 2014, to December 31, 2023, were retrieved from the Web of Science Core Collection. A total of 7,311 publications authored by 41,735 researchers from 5,967 institutions in 104 countries/regions were included. Bibliometric analysis and visualization were performed using VOSviewer, CiteSpace, and the bibliometrix R package.
    Results: Keyword co-occurrence analysis revealed six major research clusters: tumor microenvironment, various cancers, pathological processes, major mechanisms, epigenetics, and mitochondria. The top three frequently occurring keywords were glycolysis, tumor microenvironment, and mitochondria. China was the most productive country (2,966 publications), followed by Fudan University as the most productive institution (216 publications), and Liu Yang as the most prolific author (40 publications).
    Conclusion: Research on tumor metabolic reprogramming has shown rapid global growth and demonstrates significant clinical importance and application potential, especially in the context of breast cancer..
    Keywords:  bibliometric; breast cancer; glycolysis; metabolic reprogramming; tumor
    DOI:  https://doi.org/10.3389/fonc.2025.1570532
  34. Discov Oncol. 2025 Jul 06. 16(1): 1267
       BACKGROUND: Mitophagy is crucial for maintaining mitochondrial homeostasis and the internal environment of the liver. It plays a dual role in the emergence and progression of liver cancer by removing damaged mitochondria and supplying energy. Additionally, mitophagy can influence the effectiveness of liver cancer treatments through various signaling pathways.
    AIM: This study aims to summarize the research status, hot spots, frontiers, and development trends of mitophagy in liver cancer based on bibliometrics and visual analysis.
    METHODS: Publications on mitophagy in liver cancer were searched in the Web of Science Core Collection (WoSCC) database as of December 11, 2024. Vosviewer, Co-Occurrence software, CiteSpace, and SCImago Graphica were utilized for bibliometric and visualized analysis.
    RESULTS: We collected 703 publications from WoSCC. Over the past 27 years, the number of publications on mitophagy in liver cancer has shown a consistent upward trend. China leads in the number of publications and total citations. Notable institutions contributing significantly to this field include Zhejiang University, the Chinese Academy of Sciences, and Sun Yat-sen University. Key journals for publishing research on mitophagy in liver cancer are the International Journal of Molecular Sciences, Frontiers in Oncology, and Autophagy. Major contributors to this area of study include Wang Bin and Li Yan. In recent years, the mechanisms associated with mitophagy and liver cancer have remained a hot spot, including ferroptosis, aerobic glycolysis, transcription factor EB, mitochondrial dysfunction, and oxidative stress. In addition, combining sorafenib with melatonin may present a promising therapeutic option for advanced liver cancer.
    CONCLUSION: This is the first comprehensive and in-depth bibliometric study of trends and developments of mitophagy in liver cancer. It provides researchers with panoramic knowledge of this field, as well as research hotspots and future directions.
    Keywords:  Bibliometrics; Liver cancer; Mitophagy; Visualization
    DOI:  https://doi.org/10.1007/s12672-025-03098-7
  35. Front Pharmacol. 2025 ;16 1510690
       Background: Photodynamic therapy (PDT) has become a popular research direction in the field of infection control; however, there is still a lack of systematic bibliometric analysis. This paper aims to fill this gap by conducting the first comprehensive bibliometric analysis of studies related to PDT in infection control over the past 20 years, in order to gain in-depth insights into its current status and emerging trends.
    Methods: Publications related to PDT and infection control were collected from the Web of Science Core Collection database (WoSCC) from January 2004 to April 2024. Microsoft Excel was used to organize the data and analyze annual publication trends, while VOSviewer and CiteSpace were employed for the visual analysis of the selected literature.
    Results: A total of 9,711 articles and reviews meeting the inclusion criteria were retrieved for this study. Over the past two decades, publications in the field of PDT for infection control have exhibited a marked upward trajectory. China leads globally in research output and influence within this domain, establishing robust collaborative networks with the United States and Brazil. The most productive institution, journal, and author were the Universidade de São Paulo, Photodiagnosis and Photodynamic Therapy, and Michael R. Hamblin, respectively. Early studies frequently featured keywords such as "5-aminolevulinic acid," "photosensitization," "toluidine blue O," and "photodynamic inactivation." In contrast, recent research has shifted toward innovative themes such as "nanoparticles," "antibacterial nanomaterials," "aggregation-induced emission," and "photothermal therapy." Nanotechnology-based synergistic enhancement strategies for PDT and antimicrobial photodynamic therapy (aPDT) represent a current research hotspot. Nine emerging themes - "aggregation-induced emission," "wound healing," "photothermal therapy," "sonodynamic therapy," "antioxidant," "formulation," "design," "nanosheets," and "graphene oxide"-have notably influenced future directions and warrant special attention.
    Conclusion: This study is the first to comprehensively summarize the research trends and progress in PDT for anti-infective treatment through bibliometric analysis, and to clarify recent research frontiers and hot directions, providing a valuable reference for the continued exploration of PDT applications in anti-infective therapy.
    Keywords:  antibacterial; bacteria resistance; biofilm; infections; nanoparticles; photodynamic therapy; photothermal therapy
    DOI:  https://doi.org/10.3389/fphar.2025.1510690
  36. Endocr Metab Immune Disord Drug Targets. 2025 Jul 07.
       BACKGROUND: Metabolic dysfunction-related fatty liver disease (MAFLD) has emerged as the predominant chronic liver disorder among children and adolescents. Like in adults, pediatric MAFLD encompasses a disease spectrum progressing from isolated steatosis to inflammatory changes, fibrotic development, and ultimately, cirrhosis. Despite increasing recognition of MAFLD as a major pediatric health issue, current literature lacks a systematic quantitative evaluation of research trends, leading to knowledge gaps in this field. To address this limitation, a comprehensive bibliometric analysis was performed to assess global research output on pediatric MAFLD by focusing specifically on the 2014-2023 period. This analysis avoids the confounding effects of the heterogeneity of earlier data while achieving sufficient temporal resolution to reveal emerging trends that might be obscured in long-term studies. This study synthesizes existing evidence, enhances understanding of this disciplinary field, and informs future research directions in pediatric MAFLD.
    METHODS: Articles concerning children with MAFLD published from 2014--2023 were identified from the Science Citation Index-Expanded of the Web of Science Core Collection. CiteSpace software, VOSviewer, and the Online Analysis Platform of Literature Metrology were used to analyze the current publication trends and hotspots.
    RESULTS: The analysis identified 1,609 English-language articles on pediatric MAFLD published from 2014 to 2023. The United States emerged as the most active participant in international collaborations. The University of California San Diego (UCSD) demonstrated the highest research output among the analyzed institutions. Additionally, UCSD exhibited the most extensive collaborative network, engaging in frequent and substantive research partnerships with a diverse range of academic and scientific organizations. Valerio Nobili was found to be the most prolific author, with 67 articles. Keyword burst analysis revealed that cardiovascular risk factors were the most intense research hotspot.
    CONCLUSION: Current research on pediatric MAFLD warrants greater attention, particularly regarding cardiovascular risk factors. This study provides valuable references for researchers, offering insights to guide future research directions and potential collaborations.
    Keywords:  CVD; MAFLD; NAFLD; VOSviewer.; bibliometric analysis; children
    DOI:  https://doi.org/10.2174/0118715303404437250611123553
  37. Acta Parasitol. 2025 Jul 07. 70(4): 149
       PURPOSE: Paragonimiasis is a neglected tropical disease, often mistaken with common respiratory diseases, has resulted in substantial global literature. However, there is a notable lack of comprehensive literature specifically focused on paragonimiasis in Southeast Asia (SEA). To address this gap, we conducted a bibliometric assessment to provide an overview of existing literature on this disease.
    METHODS: A literature search was performed in SCOPUS, with metadata analysis using the Bibliometrix package in R. Network visualization was conducted through VOSViewer 1.6.20. Additionally, country-specific socio-economic data were obtained from the World Bank and correlated with scientific productivity using Spearman's correlation analysis, with a significant level set at p-value < 0.05.
    RESULTS: This study revealed that Thailand leads in paragonimiasis research within SEA contributing the most in terms of authors, institutions, and publications, followed by Vietnam and the Philippines. Paragonimus heterotremus emerged as the most highly cited Paragonimus species in the region. Keyword co-occurrence analysis identified three key research clusters: clinical epidemiology, molecular genetics, and immunodiagnostics. The latter has gained significant attention in recent years. Among socio-economic factors, research collaborations were statistically significant in enhancing scientific productivity in paragonimiasis research across SEA.
    CONCLUSION: The study underscores the importance of strengthening international collaborations to advance paragonimiasis research. It also highlights immunodiagnostics as a crucial area for future research and policy development.
    Keywords:  Bibliometric analysis; Immunodiagnostics; Paragonimiasis; Southeast Asia
    DOI:  https://doi.org/10.1007/s11686-025-01085-0
  38. Front Med (Lausanne). 2025 ;12 1556976
       Introduction: Discoid lupus erythematosus (DLE) is a chronic autoimmune skin disorder. Research fragmentation in DLE limits cohesive clinical and scientific progress. This bibliometric analysis aimed to clarify publication trends, collaboration networks, and emergent research themes in DLE from 2010 to 2024.
    Methods: A comprehensive search of the Web of Science Core Collection (WoSCC) used the terms "discoid lupus erythematosus" OR "lupus erythematosus discoid." English-language articles and reviews (n = 861) were identified and analyzed via the Bibliometrix package in R to examine annual output, authorship, core journals, and keywords evolution.
    Results: Annual publications increased notably after 2018, although average citation rates declined. A small group of prolific authors, led by WERTH VP, contributed disproportionately. The United States dominated publication volume and international collaboration, followed by Italy, the United Kingdom, Germany, and China. Keywords analysis showed a shift from initial emphasis on disease classification and diagnosis toward advanced therapies, immunological mechanisms.
    Conclusion: Despite growing interest in DLE, it remains underrepresented compared with systemic lupus erythematosus. Broader collaborations, refined diagnostic criteria, and robust clinical trials are essential to enhance therapeutic strategies and patient outcomes in DLE.
    Keywords:  bibliometric analysis; collaboration networks; diagnostic criteria; discoid lupus erythematosus; immunology
    DOI:  https://doi.org/10.3389/fmed.2025.1556976
  39. Front Mol Neurosci. 2025 ;18 1610844
       Objective: This study systematically investigates the evolving trends, research hotspots, and future directions in microRNA-based therapy for neuropathic pain (NP) through bibliometric analysis.
    Methods: We extracted literature related to microRNA interventions in NP from the Web of Science Core Collection database, spanning January 2009 to December 2024. A comprehensive analysis was conducted on publication trends, authorship patterns, institutional collaborations, national contributions, journal preferences, co-citation networks, and keyword clusters.
    Results: The final analysis included 250 articles, showing a steady increase in publications over the past 15 years. China was the most productive country, while the United States demonstrated the highest scientific influence. The top three institutions by publication count were Xuzhou Medical University, Nanjing Medical University, and the Chinese Academy of Medical Sciences and Peking Union Medical College. Pain was identified as the most co-cited journal. Keyword analysis revealed "differential expression" with the strongest citation burst intensity, while "peripheral nerve injury," "mechanical allodynia," and "proliferation" emerged as recent high-frequency terms.
    Conclusion: In the field of microRNA therapy for neuropathic pain, investigations into peripheral nerve injury mechanisms, neuroinflammation regulation, and miRNA differential expression patterns have been identified as current research hotspots. Emerging frontiers are now shifting toward three strategic directions: (1) development of targeted delivery systems, (2) precision modulation of nociceptive circuits, and (3) individualized therapeutic strategies. Collectively, miRNAs demonstrate significant potential as innovative NP treatments. While clinical translation of miRNA-based therapies remains a critical research priority, key challenges persist in optimizing target specificity (particularly sequence homology discrimination among miRNA isoforms) and ensuring biocompatibility of delivery platforms.
    Keywords:  bibliometrics; microRNA; neuropathic pain; therapy; visualization analysis
    DOI:  https://doi.org/10.3389/fnmol.2025.1610844
  40. Medicine (Baltimore). 2025 Jul 04. 104(27): e43221
       BACKGROUND: Anxiety and depression are mental disorders that are prevalent worldwide. Previous studies have shown that it is related to the gut microbiota. The microbiota-gut-brain axis (MGB axis) is a bidirectional signaling pathway that links the gut and central nervous systems. It plays a pivotal role in the development of psychiatric and gastrointestinal disorders, with interactions occurring via the neural, metabolic, immune, and endocrine pathways. This study aimed to reveal the research trends in the MGB axis and anxiety or depression.
    METHODS: Documents were retrieved from the Web of Science Core Collection with search terms for the microbiota-brain-gut axis and anxiety or depression. CiteSpace and VOSviewer are bibliometric tools used for co-citation analysis, co-occurrence analysis, collaborative network analysis, and keyword citation burst discovery.
    RESULTS: A total of 1816 published articles were identified, indicating a yearly upward trend. China emerged as the leading contributor, accounting for 497 publications (27.37%). Notably, Nutrients published the most articles, amounting to 77 (4.24%). Regarding authors and institutions, Cryan JF emerged as the frontrunner with remarkable 115 publications, while University College Cork topped the list with 138 articles (7.60%). Keyword analysis highlighted probiotics and inflammation as prominent areas of research, while also revealing the involvement of esteemed scholars in studying the MGB axis and anxiety or depression.
    CONCLUSION: These findings provide valuable insights into the current study and a future orientation in the field of the MGB axis and anxiety or depression. This information can assist researchers in selecting appropriate journals or collaborators and furthering their studies on the potential mechanisms of anxiety or depression, including their etiology, therapy, prevention, and prognosis.
    Keywords:  anxiety; bibliometrics; depression; microbiota–gut–brain axis; visual analysis
    DOI:  https://doi.org/10.1097/MD.0000000000043221
  41. Comput Inform Nurs. 2025 Jul 07.
      Wearable technology is widely used in nursing; however, there is lack of information on global outcomes, trends, hot topics, and thematic evolution. This study aimed to explore global outputs, trend topics, and thematic evolution of wearable technology research in nursing. This study is descriptive bibliometric analysis. The Web of Science Core Collection database was searched on July 10, 2024. Data analysis and visualization were performed using the Bibliometrix packages in R software. A total of 678 studies were published by 2915 authors in 125 different journals between 1997 and 2024. There were 1537 author keywords used in this field. The most frequent author keywords were "physical activity," "sleep," "actigraphy," "nursing," and "fatigue." Trend topics in this field were "sedentary behavior," "ecological momentary assessment," and "aged" in recent years. According to thematic map analysis, "feasibility," "research," "chronic obstructive pulmonary disease," "adolescence," and "scoping review" were isolated topics, and "communication" and "monitoring" were new topics. Additionally, "dementia" and "pressure injury" were hot topics, and "physical activity," "sleep," "wearable," "older adults," and "simulation" were the essential topic in this field. This study will help understand key authors, journals, and studies and find potential collaborators, countries, and institutions for future research.
    Keywords:  Bibliometrics; Nursing; Wearable electronic devices
    DOI:  https://doi.org/10.1097/CIN.0000000000001345
  42. Front Microbiol. 2025 ;16 1613315
       Background: Atopic dermatitis (AD) is a prevalent chronic inflammatory skin condition influenced by immune dysfunction, genetics, and environmental factors, with emerging evidence highlighting the critical role of skin and gut microbiota in its pathogenesis. This article uniquely integrates a systematic review with bibliometric analysis to map the research landscape of AD and microbiota interactions, offering a comprehensive synthesis of trends and future directions.
    Methods: We conducted a bibliometric analysis using the Web of Science Core Collection, retrieving 1,196 English-language articles and reviews published between 2009 and 2024, employing a detailed search strategy targeting AD and microbiota-related terms. Data were analyzed with tools like CiteSpace, VOSviewer, and Biblioshiny to assess publication trends, geographical contributions, institutional outputs, journal impacts, author networks, reference citations, and keyword evolution.
    Results: Research on AD and microbiota has surged since 2016, peaking at 168 publications in 2021, with the USA leading in output (360 papers) and citations (24,655). The University of Copenhagen and the Journal of Allergy and Clinical Immunology emerged as top contributors, while authors like Gallo, Richard L., and Kong, Heidi H. drove influential studies. Key findings underscore the skin and gut microbiomes as research hotspots, with Staphylococcus aureus and the gut-skin axis dominating discussions. Emerging trends from 2020 to 2024 focus on adult AD severity, prebiotics, and personalized interventions like fecal microbiota transplantation (FMT), supported by multi omics data.
    Conclusion: This study illuminates the dynamic growth and global collaboration in AD and microbiota research, emphasizing microbial dysbiosis and immune modulation as pivotal to AD management. These insights pave the way for precision medicine and dietary interventions, promising enhanced therapeutic strategies and improved patient outcomes through continued multidisciplinary efforts.
    Keywords:  atopic dermatitis; bibliometric analysis; microbial transplantation; microbiota; personalized treatment
    DOI:  https://doi.org/10.3389/fmicb.2025.1613315
  43. J Neurol Surg B Skull Base. 2025 Aug;86(4): 377-394
      Introduction  Skull base surgery has evolved from fundamental elements into a distinct multidisciplinary specialty. Using bibliometrics, we appraised the literature pertaining to skull base surgery since 1900 and studied the emergence of the specialty as a scholarly field. Methods  We queried Web of Science for all content from past presidents of the North American Skull Base Society ( N  = 31) and their self-identified forebears, influences, contemporaries, and trainees ( N  = 115). Statistical and bibliometric analyses were performed using various Python packages on article metadata. Results  Our query returned 28,167 articles. The most pertinent works ( N  = 15,529), identified algorithmically through an analysis of terms in titles, were published between 1900 and 2024 by 15,286 authors. The field exploded in the latter half of the 20th century, concurrently with increased interdisciplinary and international collaboration, and contemporaneously with the formation of centers of excellence and influential societies. Since 1950, prolific contributors to the field from neurosurgery, otolaryngology, radiology/radiation oncology, plastic surgery, and ophthalmology have increasingly subspecialized in skull base topics. The proportion of female authors in the corpus has grown from <1% in 1980 to 17% in 2023. We identify the articles that comprise the historical roots of modern skull base surgery, map the emergence of fundamental terminology within the corpus, and identify the authors who stand as key nodes of collaboration and influence. Conclusion  The field of skull base surgery was born from pioneering individuals with training in varied disciplines. The coalescence of skull base surgery into a distinct and diversified subspecialty has been powered by dedicated collaborative efforts on a global scale.
    Keywords:  bibliometrics; cranial base surgery; publications; skull base; trends
    DOI:  https://doi.org/10.1055/s-0044-1788636
  44. Bioinspir Biomim. 2025 Jul 09.
      This research undertakes a comprehensive systematic review of the overall development status and defining characteristics of the tensegrity field, employing bibliometric methods and adopting an evolutionary perspective. It also conducts an analysis of two bioinspiration pathways within tensegrity. The findings reveal a continuous growth in the number of publications related to tensegrity, coupled with an expanding scope of research areas, indicating an escalating research momentum in this domain. Based on data spanning a 35-year period on the tensegrity theme sourced from the Web of Science (WOS) database,we conducted detailed analyses of annual publication trends, significant authors, research areas, journals, and co-occurrence maps of author keywords. These analyses collectively provide a nuanced description of the current state of the tensegrity field, as well as two pivotal sub-fields: biotensegrity and tensegrity robots. In addition, through an analysis of research keywords and a timeline of evolving research hotspots within the tensegrity field, we have discerned a continuous evolution in the primary research foci: from the initial conceptual application of tensegrity in the biological domain, to the subsequent refinement and development of tensegrity theory, and finally to ongoing advancements in tensegrity robots. Biotensegrity and tensegrity robot each belong to two distinct bioinspiration pathways within the tensegrity framework. We conclude that tensegrity robot represents a pivotal juncture in the current evolution of the tensegrity discipline. Not only is the tensegrity robot an application of tensegrity in the field of engineering, but the focal points of its research, such as locomotion and control, also exhibit strong correlations with classic problems within the tensegrity theoretical paradigm.&#xD.
    Keywords:  Bibliometrics Analysis; Bioinspiration Pathways; Biotensegrity; Research Hotspot Evolution; Tensegrity Robot; Tensegrity Structure
    DOI:  https://doi.org/10.1088/1748-3190/adedec
  45. Eur J Paediatr Dent. 2025 Jul 01. 1
       BACKGROUND: Early childhood caries (ECC) is the most common oral disease in children, and its causes are complex and diverse, which has a serious impact on children's physical and mental health. Over the past decade, a large number of studies have investigated ECC in depth, and bibliometrics can reveal its research trends within specific fields.
    MATERIALS: ECC-related publications published in the last decade were retrieved from the Web of Science database. The publication year, country, institution, author, journal and keywords were visualised by using CiteSpace and VOSviewer software.
    CONCLUSION: Through bibliometric analysis, this study delineated a comprehensive landscape of ECC research hotspots and potential trends, which provided necessary information for relevant decision makers to make decisions. At the same time, it also helped researchers in this field to conduct in-depth exploration and exchanges in the clinical and academic fields, and jointly committed to ECC research, and ultimately improved the oral health of young children.
    DOI:  https://doi.org/10.23804/ejpd.2025.2395
  46. Medicine (Baltimore). 2025 Jul 04. 104(27): e43201
       OBJECTIVES: Mesenchymal stem cells (MSCs) are characterized by self-renewal and multidirectional differentiation, indicating that they have great application prospects in the treatment of knee osteoarthritis (KOA). The purpose of this study was to explore the research status, hot spots and future research trends of the use of MSCs in KOA treatment and to provide a basis for research directions and applications in this field.
    METHODS: We searched the Web of Science Core Collection database from 2012 to 2022 to identify literature related to the use of MSCs for the treatment of KOA. All the included studies were subjected to bibliometric analysis via Hiplot Pro and CiteSpace software to produce statistics and visual analyses of data, including the nation, institution, author, keyword and reference.
    RESULTS: A total of 1537 studies were analyzed. These studies had been cited 41,916 times. The 3 countries with the greatest number of published papers were the USA (415), China (374), and Italy (130). Two U.S.-based institutions, i.e., Hospital for Special Surgery and Rush University, had the greatest number of published papers. The representative journals in this field were Stem Cells, Annals of Rheumatic Diseases, Osteoarthritis and Cartage and the American Journal of Sports Medicine. Keyword co-occurrence and co-citation reference analyses revealed that the key research theme in this field in the past decade has been the efficacy and mechanism of MSCs for treating KOA (articular cartilage). These findings preliminarily confirmed the clinical value of MSCs for treating KOA.
    CONCLUSIONS: The use of MSCs to treat KOA has great potential for clinical application and has been widely studied by researchers. The clinical efficacy and mechanism of action of MSCs are still the core content. In KOA treatment, adipose-derived MSCs, MSC-derived exosomes and the risk of MSC application are future research areas.
    Keywords:  MSCs; bibliometric analysis; knee osteoarthritis; mesenchymal stem cells
    DOI:  https://doi.org/10.1097/MD.0000000000043201
  47. Discov Oncol. 2025 Jul 11. 16(1): 1307
       PURPOSE: Cancer has emerged as a major public health concern in Ecuador, reflecting global trends. Thus, it is imperative to understand the country´s cancer research landscape. We aim to conduct a bibliometric analysis of Ecuadorian cancer research publications from 2008 to 2021 to identify research trends, institutional contributions, international collaborations, and the association with the national cancer burden.
    METHODS: Articles were retrieved from Scopus, PubMed, and LILACS databases. Descriptive statistics and chi-square tests were employed to analyze different bibliometric indicators.
    RESULTS: A marked increase in cancer-related research output was observed, particularly after 2014. The most common study designs were case reports (n = 244, 30.7%), cross-sectional studies (n = 174, 21.9%) and review articles (n = 131, 16.5%). Universities were the main contributors to national cancer research, accounting for 32.4% (n = 256) of all publications, with private institutions more frequently publishing in higher-ranked journals. Collaborative efforts between universities and hospitals represented 25.3% (n = 200) of publications, though 45.1% of these were indexed in the lowest SCImago Journal Rank quartile (Q4). The most frequently studied cancer types by body location/system were gastrointestinal, gynecologic, and breast cancer. This trend contrasts with national cancer statistics reported in 2022, in which the most common cancer types were breast, prostate (genitourinary), and stomach (gastrointestinal) cancers.
    CONCLUSION: Our study provides a comprehensive overview of oncology research in Ecuador over a 14-year period. While research output has increased, there remains a need to enhance research quality and ensure closer alignment with the country's primary cancer burdens to better inform national cancer control strategies.
    Keywords:  Bibliometric analysis; Cancer research; Ecuador.; Public health
    DOI:  https://doi.org/10.1007/s12672-025-03168-w
  48. Am J Forensic Med Pathol. 2025 Jul 07.
      The NAME annual meeting focuses on platform presentations as a means of sharing research, ideas, and education; however, little is known about the rate at which these presentations are subsequently published. This study analyzed trends related to publication outcomes of 651 presentations given from 2013 to 2022. Using Python scripts that queried the PubMed database, we found that 175 presentations (27%) went on to be published in the peer-reviewed literature [we also accounted for presentations published in Academic Forensic Pathology (AFP) in the years when AFP was not indexed in PubMed]. The journals AFP and the AJFMP accounted for most of the publications, but over 30 other journals were identified. Publications in AFP declined in the latter years of our study range, while publications in AJFMP increased. First authors from NMS, the CDC, and Ottawa-based institutions were among the most likely to publish their presentations. To assess the performance of our automated scripts, we also performed a manual Internet/PubMed search of presentation titles and authors; our automated scripts detected 97% of all matched presentations with PubMed. Information gleaned from studying bibliometric trends can help inform strategies for improving future educational programs.
    Keywords:  NAME meeting; abstract outcomes; bibliometrics; forensic pathology; publishing trends
    DOI:  https://doi.org/10.1097/PAF.0000000000001061
  49. Front Clin Diabetes Healthc. 2025 ;6 1603206
       Background: Diabetic wounds are a serious complication for diabetic patients, characterized by refractoriness, high recurrence rates, and susceptibility to infection. Although current guidelines recommend evidence-based treatment strategies, clinical outcomes remain suboptimal. This paper reviews the current research status and development trends in diabetic wound treatment.
    Methods: Articles on diabetic wound treatment published between 2014 and 2023 were identified using the Web of Science Core Collection database, resulting in a total of 9,099 articles. Bibliometric methods were employed to analyze authors, institutions, countries, journals, keywords and references using CiteSpace and VOSviewer.
    Results: China has published the most articles in the field, followed by the United States. Shanghai Jiao Tong University is the leading institution in diabetic wound treatment research, and David G. Armstrong from the United States has made significant contributions to this field. "Wound Repair and Regeneration" was identified as the most influential journal. Cluster analysis of keywords revealed four main categories: (1) mechanisms of diabetic wound healing, (2) prognosis, (3) treatment, and (4) management.
    Conclusion: This paper systematically reviews the research on diabetic wound treatment from 2014 to 2023, outlining and forecasting global research hotspots and trends. Future research is expected to focus on treatment strategies for diabetic wounds, while interdisciplinary collaboration and advancements in intelligent management technologies have the potential to improve patient outcomes.
    Keywords:  bibliometric; diabetic wounds; management; prognosis; treatment
    DOI:  https://doi.org/10.3389/fcdhc.2025.1603206
  50. Health Sci Rep. 2025 Jul;8(7): e71007
       Background: Despite the prevalence of vulvar lichen sclerosus (VLS) as a chronic skin disease in clinical settings, there is a notable absence of a comprehensive bibliometric analysis summarizing the existing literature on this topic. The aim of this study is to offer clinicians, researchers, and other interested parties an up-to-date overview of the research status and emerging trends in VLS through the use of bibliometric analysis.
    Methods: The present research employed a thorough examination of the Web of Science Core Collection to identify publications pertaining to VLS within the time frame of January 1, 1994, to December 31, 2023. A total of 1698 publications were scrutinized utilizing Microsoft Excel software and various visualization tools, including CiteSpace, VOSviewer, and Pajek, to discern specific characteristics.
    Results: The current research encompassed a total of 1,698 articles pertaining to VLS. The analysis of citation bursts and co-citation patterns has revealed a high level of confidence in the effectiveness and safety of topical corticosteroids for the treatment of VLS, establishing them as the preferred primary treatment for this condition. Since 2018, there has been a significant increase in VLS publications, with the United States and United Kingdom emerging as leading contributors. Research has moved from examining past pathological changes like "epidermal atrophy" to focusing on "long-term treatment management," and improving "quality of life". The exact mechanism of VLS remains unclear, but it is linked to cytokine immune regulation, oxidative stress, and potential epigenetic changes or genetic mutations in susceptible individuals. It could also develop into vulvar squamous cell carcinoma.
    Conclusions: Institutions are expected to allocate more resources for VLS prevention and long-term management.
    Keywords:  bibliometric; hotspots; topical corticosteroids; trends; vulvar lichen sclerosus
    DOI:  https://doi.org/10.1002/hsr2.71007
  51. J Pediatr Orthop. 2025 Jul 09.
       BACKGROUND: The annual meeting program committees for orthopaedic subspecialty societies now receive more abstract submissions while conference durations remain similar. This study estimated the quality of the Pediatric Orthopaedic Society of North America (POSNA) annual meeting by analyzing abstract acceptance and publication characteristics.
    METHODS: Abstracts featured in recent POSNA annual meetings (2017 to 2020), whereafter presentations had 3 subsequent years to reach publication were reviewed to determine annual acceptance rates, publication status, country of origin, study type, level of evidence, journal impact factor (JIF), and time to publication. Abstracts published with dissimilar results, altered methodology, or lacking the original first author were excluded.
    RESULTS: The abstract acceptance rate during the 4-year study period averaged 32%±3% despite the number of submitted abstracts varying per year. Among 1306 included abstracts, 760 (58.2%) were published in peer-reviewed journals. The vast majority (95%) were published after the annual meeting. The JIF of publications averaged 2.8±2.0 without significant variation between years. Featured abstracts were most commonly retrospective (n=510; 67.1%). Podium presentations were published at a significantly higher rate than posters (63.1% vs. 51.8%, P<0.001), and had a higher average JIF (2.9±2.3 vs. 2.5±1.0, P=0.006). A total of 137 unique journals published abstracts, with The Journal of Pediatric Orthopaedics publishing the highest proportion of articles (n=231).
    CONCLUSION: Abstracts featured in the most recently applicable POSNA annual meetings boast high rates of subsequent publication in relevant journals. This implies that the POSNA annual meeting offers strong educational value. When compared with posters and e-posters, podium presentations were more often published and appeared in higher impact journals. However, the prevalence of publication among both podium and poster presentations is encouraging for authors looking to substantiate the educational value of their research.
    LEVEL OF EVIDENCE: Leve IV-retrospective study.
    Keywords:  abstract; acceptance rate; podium; posna; poster; presentation; publication rate
    DOI:  https://doi.org/10.1097/BPO.0000000000003038
  52. Int J Eat Disord. 2025 Jul 09.
      Lee and Chi analyze publication trends and research themes on eating disorders over the last five decades. Among the factors driving increased annual citations were publications in journals focused on neuroscience. This observation underscores a growing focus on the neurobiological basis of eating disorders. This commentary highlights a few features of this development and outlines several potentially fruitful areas for future neuroscience-based research.
    Keywords:  anorexia nervosa; bibliometric analysis; binge‐eating disorder; bulimia nervosa; eating disorders; neuroscience
    DOI:  https://doi.org/10.1002/eat.24504
  53. Front Med (Lausanne). 2025 ;12 1572161
       Objective: This study aimed to identify the principal research areas and trends in the nuclear factor kappa B (NF-κB) signaling pathway in knee osteoarthritis (KOA).
    Methods: The Web of Science core collection (WoSCC) database was searched for studies related to the NF-κB signaling pathway in KOA published between 2004 and 2023. The complete records of the literature and all citations were exported from the WoSCC database to plain text file and tab-delimited file, respectively. The exported data were then analyzed. Analysis was conducted using CiteSpace (version 1.6.20) and VOSviewer (version 6.1. R6), OriginPro 2021 (version 9.8.0.200), SCImago Graphica (version 1.0.44), and the bibliometric website (http://bibliometric.com/).
    Results: A total of 752 studies were included in this analysis, and the results demonstrated an overall increasing trend in the number of published papers and citation frequency over the period 2004-2023. China leads in terms of the number of publications, with 387 publications, followed by the United States (118), and Japan (45). The institutions with the highest number of publications were China Medical University (28) and The Second Affiliated Hospital of Wenzhou Medical University (Yuying Children's Hospital) (24). The most frequently occurring keywords were "articular cartilage," "inflammation," "activation," and "expression." Furthermore, recent keywords with high research intensity included "histopathology," "mesenchymal stem cells," "subchondral bone," and "hip." Toll-like receptor 4 (TLR4), monosodium iodoacetate (MIA), and high-performance anion-exchange chromatography with pulsed amperometric detection (HPAE-PAD) were popular research topics.
    Conclusion: The bibliometric analysis revealed that studies of NF-κB signaling pathways in KOA have predominantly focused on the TLR4/NF-κB signaling pathway and exosomes. NF-κB plays a core regulatory role in KOA, with molecular evidence supporting its involvement in inflammation, cartilage degradation, and pain signaling. However, current research is limited by the lack of in vivo imaging techniques to visualize NF-κB activity in real-time. Future research should prioritize the development of such imaging modalities and integrate multi-omics approaches, including single-cell and spatial transcriptomics, to analyze pathway heterogeneity and identify novel therapeutic targets. This integrative approach will facilitate a deeper understanding of the pathogenesis of KOA and enable the development of more effective treatment strategies.
    Keywords:  NF-κB; bibliometric analysis; knee; osteoarthritis; signaling pathway
    DOI:  https://doi.org/10.3389/fmed.2025.1572161
  54. BMJ Open. 2025 Jul 05. 15(7): e098811
       OBJECTIVES: The purpose of this study was to analyse the speech-language pathology (SLP) literature from 2012 to 2022 and evaluate authorship trends and factors associated with gender disparities.
    DESIGN AND OUTCOME MEASURES: Authorship across journals published by the American Speech-Language-Hearing Association (ASHA) was evaluated. Outcomes collected from each article included the gender of the first and senior authors, author department affiliations, study type, reported funding source and the country of origin. Three sets of linear regression models were explored to determine the probability of male first authorship, of male senior authorship, and of a study being funded.
    RESULTS: A total of 2754 articles were identified for inclusion. The majority of the literature was authored by females, with 77% of first authors and 68% of senior authors being female. Studies with a male senior author were shown to be 4.05-4.67 times more likely to have a male first author than with a female senior author. Male senior authors were over-represented relative to their proportion of ASHA membership compared with female senior authors. Male authorship was associated with certain subtopics, including voice, stuttering and motor speech. Funding probability decreased for all authors regardless of gender between 2012 and 2022.
    CONCLUSIONS: Implicit gender bias and societal gender stereotypes lead to a greater number of women in the field of SLP; the same biases and stereotypes often limit the research productivity and academic leadership potential of women in the field. Addressing these biases and stereotypes is vital to move towards gender equity in the field.
    Keywords:  Education, Medical; Research Design; Speech pathology
    DOI:  https://doi.org/10.1136/bmjopen-2025-098811
  55. Front Med (Lausanne). 2025 ;12 1553915
      Plant-derived exosome nanovesicles (PDENs) have emerged as eco-friendly, sustainable and highly efficient platforms for drug delivery, attracting significant attention in biomedical research. As a consequence, PDENs have become a focus for multidisciplinary investigation. Despite extensive research, impartial and comprehensive evaluations of PDENs-based theranostic applications remain scarce. This study fills this gap by using bibliometric techniques to systematically analyze 15 years of scientific publications. The analysis is based on data retrieved from the Web of Science Core Collection, covering studies published from 2009 to 2024. Advanced bibliometric tools and visualization techniques were utilized to ensure a rigorous and detailed analysis. The results highlight China's dominant position, contributing 35.09% of all publications, thereby significantly influencing the research trajectory in this field. Key contributions have been made by institutions such as the Nanjing University of Chinese Medicine, the Chinese Academy of Sciences and Zhejiang University, with Stefania Raimondo emerging as the most productive researcher. International Journal of Molecular Sciences stands out as the journal with the largest number of publications in this area. The study also identifies key related diseases, including colonic diseases, vascular diseases, osteosarcoma and DNA virus infections, etc. In conclusion, this study offers a detailed assessment of advancements and evolving patterns in PDENs-based theranostics over the past 15 years. It emphasizes critical areas that require further focus and systematic exploration by the scientific community. Additionally, this analysis identifies major research hotspots and emerging boundaries, providing scholars and research institutions with strategic insights to shape future studies.
    Keywords:  bibliometrics; biotherapeutic applications; delivery strategy; plant-derived exosome-like nanoparticles; theranostics; visualized analysis
    DOI:  https://doi.org/10.3389/fmed.2025.1553915
  56. J Dent. 2025 Jul 08. pii: S0300-5712(25)00409-9. [Epub ahead of print] 105965
       OBJECTIVE: to assess the scientific profile of clinical trials utilizing universal adhesives in dentistry through a bibliometric and altmetric analysis.
    METHODOLOGY: A search was conducted in May 2025 on Web of Science (WoS-CC) and Scopus. Two researchers selected articles and extracted key study characteristics. VOSviewer was used to generate bibliometric networks. Dimensions was consulted to measure altmetric data. Google Trends was consulted to investigate the global popularity of research. Spearman's correlation was used to evaluate the correlation of citations.
    RESULTS: A total of 130 studies were included. The studies predominantly investigated clinical performance (n = 120) of universal adhesives in the restoration of non-carious cervical lesions (NCCLs) (n = 82), with a double-blind design (n = 77). The Journal of Dentistry (n = 26) stood out. The criteria of the World Dental Federation (FDI) were the most commonly used (n = 50), and the Scotchbond Universal adhesive was the most investigated product (n = 70). As an adhesive strategy, most studies used only the self-etch technique (n = 65). The majority of papers were published in Brazil (n = 60), with Loguercio AD (n = 34) and Reis A (n = 27) being the most frequent authors. VOSviewer revealed significant collaborations among authors. According to Dimensions, notable mentions were primarily identified on Mendeley.
    CONCLUSIONS: Clinical studies on universal adhesives were primarily published by Brazilian authors and institutions, with the highest number of publications recorded in 2024. Most studies used Scotchbond Universal to restore NCCLs and assessed clinical performance.
    CLINICAL SIGNIFICANCE: By identifying the most studied clinical conditions, products, methodologies, and publication trends, this bibliometric and altmetric analysis offers valuable insights to clinicians and researchers into the current scientific landscape of universal adhesives.
    Keywords:  Altmetric Analysis; Clinical Trial; Universal Bond; Universal adhesive; bibliometric Analysis
    DOI:  https://doi.org/10.1016/j.jdent.2025.105965
  57. Int J Food Sci. 2025 ;2025 8837527
      This study examines global research trends in edible insects using a bibliometric approach to evaluate country contributions, which are essential for understanding the geographic distribution of research capacity, funding availability, and regional priorities. Country-specific insights highlight disparities in research output and infrastructure, providing a foundation for exploring how different nations adopt edible insects in food systems and feed applications. Based on 2291 articles indexed in the Scopus database from 2005 to 2024, the analysis utilized Bibliometrix in R software and VOSviewer for bibliometric visualization. To enhance data processing and presentation, Scimago Graphica, Tableau, and MS Excel were employed for advanced visualizations. The findings reveal the rapid growth in edible insect research, with Europe leading in output, particularly from Italy, Belgium, and the Netherlands. Asia shows strong contributions, with South Korea and China emerging as key players supported by robust funding frameworks. The United States, United Kingdom, and the Netherlands host the largest number of journals, facilitating widespread knowledge dissemination. Collaborative networks, led by Germany, Italy, and Kenya, drive advancements, while the Netherlands ranks highest in citations, underscoring the impact of its research. Emerging themes include bioactive compounds, functional foods, circular economy practices, and sustainable feed for livestock and aquaculture, aligning with global sustainability goals. Insects like black soldier fly larvae, crickets, and mealworms are being explored as efficient protein sources for animal feed. Addressing food safety, allergenicity, and cultural barriers remains critical. Future research should focus on scalable farming, innovative food processing, and underutilized species, with global collaboration and sustainability alignment being pivotal.
    Keywords:  alternative protein; bibliometric analysis; country-level analysis; edible insects; emerging themes; functional foods; geographic distribution; sustainable feed
    DOI:  https://doi.org/10.1155/ijfo/8837527
  58. Front Neurol. 2025 ;16 1588130
       Introduction: This study employs bibliometric analysis to systematically investigate the evolutionary trajectory and disciplinary dynamics of post-stroke aphasia mechanism research from 2004 to 2024.
    Methods: Through multidimensional examination of 3,492 publications from Web of Science Core Collection.
    Results: We identify paradigm shifts characterized by three distinct phases: initial reliance on neuroimaging for anatomical localization of language-area lesions, subsequent focus on white matter remodeling and neuromodulation techniques validating neural plasticity hypotheses, and recent advances in functional connectomics integrated with multimodal intervention strategies. International collaboration exhibits marked geographic disparities, with the United States, United Kingdom, and Australia forming the knowledge-production nucleus through leadership in neuromodulation innovation and brain network research. While China ranks among top contributors in publication volume, it confronts dual challenges of insufficient transnational cooperation and underdeveloped culturally-adapted assessment tools. Notably, a persistent technology-practice gap persists as a critical bottleneck - despite neuroimaging's dominance in mechanistic studies, clinical integration of functional assessment tools remains suboptimal, and neuromodulation trials demonstrate attenuated effect sizes compared to preclinical models. Temporal analysis reveals research imbalance favoring acute-phase intervention studies over chronic-phase management research. Emerging technologies such as digital therapeutics exhibit limited research clustering.
    Discussion: Based on these findings, we propose a multidimensional framework integrating precision neuromodulation, cross-cycle rehabilitation pathways, and digital ecosystems, prioritizing multicenter brain network database development and dialect-adaptive assessment scales. This investigation provides empirical mapping of current research landscapes and actionable insights for future investigations in post-stroke aphasia rehabilitation.
    Keywords:  aphasia after stroke; bibliometrics; post-stroke aphasia (PSA); research Frontiers; visualization analysis
    DOI:  https://doi.org/10.3389/fneur.2025.1588130
  59. Front Med (Lausanne). 2025 ;12 1593178
       Background: The management of long-term cardiotoxicity has become increasingly challenging despite the growing utilization of targeted therapies to enhance progression-free and overall survival rates. Although there is a proliferation of literature on the incidence and mechanisms of cardiotoxicity induced by targeted therapies, no comprehensive analysis of the publication landscape has addressed the unmet medical needs in this area. This study aimed to characterize global research trends, map collaborative networks, and highlight unresolved issues in cardiotoxicity management to fill the gaps in this field and inform future research.
    Method: This study conducted a bibliometric analysis of articles concerning targeted therapy-induced cardiotoxicity published between 2004 and 2024 from the Web of Science (WOS) database using VOSviewer and CiteSpace. A total of 1,054 publications from 71 countries/regions and 2,058 research institutions were examined.
    Result: The number of publications has shown an average annual increase of 50 articles from 2004 to 2024. Key research topics in targeted therapy cardiotoxicity encompass breast cancer, heart failure, and drug delivery. The most cited publication is a guideline titled "Prevention and Monitoring of Cardiac Dysfunction in Survivors of Adult Cancers: American Society of Clinical Oncology Clinical Practice Guideline." These results indicate a rising trend in research on tumor-targeted therapy cardiotoxicity over the past two decades. Recent research trends and future directions primarily focus on two key areas: the development of novel nanocarriers aims to enhance therapeutic efficacy while reducing cardiac toxicity, and the exploration of mechanisms underlying cardiac injury caused by targeted therapeutic drugs is crucial, along with the investigates drug interventions to counter these mechanisms or the application of alternative techniques for the prevention, alleviation, or treatment of cardiac injury.
    Conclusion: This study provides a comprehensive overview of targeted therapy-induced cardiotoxicity research from 2004 to 2024. By identifying key research priorities, this analysis addresses critical gaps in current knowledge. Future endeavors should prioritize translational innovations and multidisciplinary clinical frameworks to enhance therapeutic safety.
    Keywords:  CiteSpace; VOSviewer; bibliometrics; cancer; cardiotoxicity; targeted therapy
    DOI:  https://doi.org/10.3389/fmed.2025.1593178
  60. Proc Biol Sci. 2025 Jul;292(2050): 20250960
      Publication practices accumulate to affect credibility and career advancement. Understanding authorship and citation practices is critical to addressing inequities. While citation bias has been demonstrated in several fields, it remains uncharacterized in infectious disease dynamics (IDD), a quantitative, interdisciplinary domain highly visible during the COVID-19 pandemic. We analyse IDD articles and their bibliographies from 2000 to 2019 using machine-learning algorithms to infer the gender and race/ethnicity of each article's lead and senior authors. We examine authorship and citation patterns by gender and racial group across geographic scales, including characterizing the author composition of each article's bibliography relative to the field. Our analysis reveals persistent gender and race imbalances in IDD research. Man-authored and White-authored publications dominate the field, with little progress in racial diversification of US and UK publications over the last two decades. Woman-authored articles have the most representative citation practices but are undercited, especially when women are senior authors. In the USA and UK, most citations feature White lead and senior authors, even when citing articles have lead or senior authors of colour. These findings underscore the urgent need for more inclusive IDD research practices. We discuss possible mechanisms and solutions to create opportunities for researchers from underrepresented groups.
    Keywords:  citation analysis; infectious disease dynamics; science of science
    DOI:  https://doi.org/10.1098/rspb.2025.0960
  61. J Neurosurg. 2025 Jul 11. 1-12
       OBJECTIVE: The Neurosurgery Research & Education Foundation (NREF) Medical Student Summer Research Fellowship (MSSRF) is a prominent research fellowship offered to medical students. The authors investigated how gender and academic characteristics of the MSSRF applicant pool have evolved since the fellowship's inception. Likewise, they evaluated the impact of the MSSRF on career progression, scholarly productivity, and subsequent grant funding within neurosurgery.
    METHODS: A list of MSSRF awardees (2008-2023) and nonawardee applicants (2015-2023) was provided by the NREF. Demographic and career progression variables were obtained through publicly available platforms, and scholarly productivity metrics were collected using Clarivate Web of Science. The Fisher's exact test was used to compare categorical variables, the Mann-Whitney U-test was used to compare continuous variables, and the Mann-Kendall test was used to assess trends. Binary logistic regression was utilized to explore factors associated with matching into neurosurgery.
    RESULTS: A total of 297 awardees from 2008 to 2023, 183 awardees from 2015 to 2023, and 355 nonawardees from 2015 to 2023 were included. A greater percentage of awardees attended a top 20 medical school than nonawardees (p = 0.002). There was a statistically significant upward trend in the percentage of female awardees since 2010 (p = 0.01). Between 2015 and 2023, there was no difference in the percentage of awardees who matched into neurosurgery compared to nonawardees (60.5% vs 50.2%, p = 0.07), but awardees matched into better Doximity-ranked neurosurgery residency programs (p = 0.04). While there was no difference in the number of total publications or first author publications before residency between awardees and nonawardees who matched into neurosurgery since 2015, awardees had a higher h-index (5.0 vs 4.0, p = 0.03). Specifically among awardees who pursued neurosurgery since 2008, there was a statistically significant upward trend in the median number of total publications before residency (p < 0.001), first author publications (p = 0.001), and h-index (p = 0.007). Among neurosurgery attending physicians who received MSSRF awards, 64.7% practiced in an academic setting. Across academic neurosurgery attending physicians who received MSSRF awards, the ratio of NREF MSSRF award dollars to subsequent National Institutes of Health (NIH) grant funding dollars was $1:$9.05.
    CONCLUSIONS: The NREF MSSRF is associated with high-quality research and strong academic productivity among aspiring medical students, with a high proportion of awardees pursuing neurosurgery and matching into top-ranked residency programs. Likewise, this early-career fellowship has a substantial return on investment in terms of subsequent NIH grant funding.
    Keywords:  AANS; NREF; awards; career outcomes; medical student; neurosurgery; neurosurgical education
    DOI:  https://doi.org/10.3171/2025.3.JNS241757
  62. Drug Des Devel Ther. 2025 ;19 5517-5538
       Background: Artemisinin, found in the traditional Chinese medicine (TCM) Artemisia annua, has demonstrated remarkable efficacy in therapeutics and holds significant potential as a pharmaceutical drug in cancer. Until now, there have been no systematic scientometrics studies to analyze the research trend of artemisinin and its derivatives in cancer.
    Aim of the Study: We conducted this bibliometric study with the aim of providing researchers in the field with an all-around summary of artemisinin and its derivatives in cancer, visualizing current research advances, identifying hotspots, and ultimately outlining cutting-edge trends for future development.
    Methods: A total of 927 relevant publications from 1990 to 2023 were accessed from the WOSCC database and analyzed bibliometrically utilizing software including CiteSpace VOSviewer and Microsoft Excel.
    Results: Global publications in artemisinin and tumor therapy have steadily increased. China is considered the leading country in terms of publication numbers, and Chinese scholars have been influential in the field of artemisinin and its derivatives in the prevention and treatment of cancer. Cluster analysis of co-cited references depicted artemisinin-type drugs, bax-mediated intrinsic pathways, and infected erythrocytes as the most noteworthy topics. In contrast, the keywords analysis revealed a strong emphasis on the issues of cancer, in-vitro, cycle arrest, anticancer activity, and plasmodium-falciparum.
    Conclusion: This study provides a comprehensive overview of relevant research trends by explicitly analyzing the published literature associated with artemisinin and its derivatives in cancer. The results of this multifaceted analysis can provide valuable data that offers ample insights for the field and for researchers wishing to venture into the field.
    Keywords:  artemisinin; bibliometric analysis; cancer; therapeutic agent; traditional Chinese medicine
    DOI:  https://doi.org/10.2147/DDDT.S514219
  63. Biomater Transl. 2025 ;6(2): 151-164
      Spinal cord injury (SCI) is recognised as a debilitating condition that often leads to considerable disability and functional limitations. Exosomes, which can be derived from various cell types including bone marrow mesenchymal stem cells, adipose-derived stem cells, dental pulp stem cells, and macrophages, play a pivotal role in the post-SCI landscape. Collectively, it has been observed that these exosomes can modulate the immune response following SCI, regulate the inflammatory environment, inhibit secondary tissue damage, and support neuronal survival and axonal regrowth. However, it is noted that exosomes from different sources exhibit distinct characteristics. Therefore, it is deemed essential to gain a comprehensive understanding of the current knowledge and research directions regarding exosomes in SCI to foster the development of effective therapeutic interventions. In this bibliometric analysis, we conducted to search retrieve pertinent articles from the Web of Science Core Collection and identify pivotal publications, authors, institutions, countries, and keywords that have contributed significantly to the field. This bibliometric analysis offers a thorough examination of the present knowledge landscape and prevailing research trends pertaining to exosomes in the context of SCI. It acts as a valuable asset, catering not only to researchers but also to clinicians and policymakers engaged in research on SCI and therapeutic advancement. Ultimately, this knowledge mapping can advance our understanding of exosome biology and pave the way for innovative interventions to improve outcomes for individuals affected by SCI.
    Keywords:  bibliometric analysis; dental pulp stem cells; exosomes; extracellular vesicle; spinal cord injury
    DOI:  https://doi.org/10.12336/bmt.24.00004
  64. Medicine (Baltimore). 2025 Jul 04. 104(27): e43143
      Congenital tracheal stenosis (CTS) is a rare and highly fatal airway obstructive disorder. Recent years have seen the recognition of several forms of surgery as safe and effective means of improving the survival of children with CTS. It is important to complement the comprehensive and systematic pulse combing analysis of this research field. In order to give future researchers ideas and references, we examine the literature on the surgical treatment of CTS during the past 40 years and compile a summary of the cutting-edge trends and research hotspots in this area. A search was conducted through the Web of Science database's core dataset for relevant publications pertaining to the surgical treatment of CTS from 1983 to 2024. CiteSpace 6.3, VOSviewer 1.6.18, Scimago Graphica 1.0.26, R-bibliometrix 4.6.1, and Pajek 5.16 tools were used for analysis and visualization. 327 publications total were found. With 82 papers, the US ranked first. Great Ormond Street Hospital for Children National Health Service Foundation Trust was ranked first for institutions with 24 papers. With 48 papers, the Journal of Pediatric Surgery had the top spot among journals, while Elliott MJ had the highest ranking among authors with 15. Study keywords were sliding tracheoplasty, congenital long tracheal stenosis, airway reconstruction, interventional procedures, airway stenting, intact tracheal rings, degradable airway stents, modified sliding tracheoplasty, trachelectomy, difficult intubation, extracorporeal membrane oxygenation, central airway stenosis, balloon-expandable metal stents, airway mucosa, Pierre Robin sequence, ventilation. The existing body of research indicates that there is still a great deal of untapped potential in the surgical treatment of CTS. The research hotspot is the clinical efficacy study of selecting the optimal timing and sequence of surgical procedures for the treatment of CTS combined with cardiovascular disease, the use of extracorporeal circulatory devices as an aid to reduce the surgical mortality rate, and the exploring preoperative predictive risk by reviewing patient cases to explore preoperative predictive risk factor studies. The reliability and feasibility of a new index to objectively assess tracheal flow function before and after surgery, new bioabsorbable scaffolds with longer degradation times and increased radial expansion, and new technologies such as visualization surgery.
    Keywords:  CTS; CiteSpace; VOSviewer; bibliometrics; congenital; surgical treatment; tracheal stenosis
    DOI:  https://doi.org/10.1097/MD.0000000000043143
  65. J Endod. 2025 Jul 04. pii: S0099-2399(25)00393-0. [Epub ahead of print]
       INTRODUCTION: Our hypothesis explored representation in women's leadership positions in endodontic academia to assess publication participation of men and women from 2010- 2023 and to test academic rank disparities by comparing men and women faculty rank, gender, and citation impact.
    METHODS: Authors' names were downloaded from a PubMed search of publications in the Journal of Endodontics, International Endodontic Journal, and Dental Traumatology between 2010 and 2023. Editorial board members and reviewers were obtained from journal pages. Gender API software was used to determine gender based on first names. Fifty-four U.S. endodontic post-graduate departments were identified on the American Association of Endodontists website in 2022, and faculty information and rank were verified on departmental websites. Respective H-index scores were calculated using Harzing's Publish or Perish software.
    RESULTS: Of the 36,587 authors, 35% were women, and the percentage of women authors increased by 0.5% per year (95% CI = 0.3 to 0.6). Compared to women, men published more than women, outnumbered women as reviewers, and held more positions on editorial boards. The educational leadership of U.S. endodontics programs is 29% women. Women comprise 23% of chairs, 21% of post-graduate directors, and 47% of pre-doctoral director positions (P = 0.013). However, among academic leaders in the US, faculty rank is not associated with gender (P=0.396) after scholarly impact and leadership roles are adjusted for.
    CONCLUSIONS: Ultimately, the leadership role predicts rank, not gender. This suggests that women need to take action to apply for more leadership positions.
    Keywords:  Dental education; Gender differences; Inequalities; Lifestyle(s); Publishing; Social determinants
    DOI:  https://doi.org/10.1016/j.joen.2025.06.021
  66. JB JS Open Access. 2025 Jul-Sep;10(3):pii: e25.00064. [Epub ahead of print]10(3):
       Background: Orthopaedic traveling fellowship programs provide surgeons with valuable opportunities for professional growth and specialized learning. However, there has been limited research on the impact of such programs on scholarly success and career advancement. The aim of this study was to evaluate the demographic, academic, and scholarly outcomes of traveling fellowship participants.
    Methods: This study was a retrospective analysis of orthopaedic surgeons who participated in a traveling fellowship program from 1989 to 2024. Demographic and academic characteristics were collected for each traveling fellowship recipient, including residency program attended, fellowship specialty, fellowship institution, academic rank, current practice environment, and leadership roles. The Scopus database was used to determine individual H-indices and number of publications. Other characteristics included board position in a major orthopaedic society, National Institutes of Health (NIH) research funding, Orthopaedic Research and Education Foundation (OREF) grant recipient, advanced degrees, and editorial board position in an orthopaedic journal. Descriptive and regression statistics were used for the study.
    Results: Of the 558 physicians who participated in an orthopaedic traveling fellowship, demographic and academic information was available for 506 of them (90.7%). Of these, the majority (96.6%) only completed 1 traveling fellowship. Predominantly, recipients were male (90.7%) and White (79.1%) and had completed a sports fellowship (33.0%). Current practicing environment was often academic (76.5%), with most holding the rank of professor (51.0%). Seventy-two participants (14.2%) had a leadership role as chair and 48 (9.5%) were division chiefs. Participants had an average H-index of 35.7 and averaged 169.9 publications. One hundred seventy-three fellowship recipients (34.2%) received an OREF grant and 67 (13.2%) received NIH research funding. Fellowship participants who received an OREF grant or NIH funding were more likely to have a higher faculty rank, higher H-index, and an increase in the number of publications (p < 0.001 for all).
    Conclusion: The lessons, skills, and knowledge from traveling fellowships appear to play an important role in shaping the academic and scholarly career of orthopaedic surgeons.
    Level of Evidence: Level IV. See Instructions for Authors for a complete description of levels of evidence.
    DOI:  https://doi.org/10.2106/JBJS.OA.25.00064
  67. Virol J. 2025 Jul 05. 22(1): 224
       BACKGROUND: Dysbiosis of the human gut virome is associated with a variety of factors, yet the underlying mechanisms remain poorly understood. This study aims to map the current research trajectory of the human gut virome and propose a strategic framework for future scientific research.
    METHODS: A bibliometric analysis was performed on articles retrieved from the Web of Science (WoS) Core Collection database covering the period 2000 to 2024, utilizing VOSviewer, CiteSpace, and the R software environment.
    RESULTS: Over the past 20 years, the number of published papers and citations in the field of enterovirus research has shown a significant growth trend. This trend is attributed to the breakthrough progress of high-throughput sequencing technology and the iterative upgrade of viral genome databases such as CheckV, which has made the classification resolution of the enterovirus group more accurate and discovered a large number of unknown bacteriophages. Technological innovation has led to a fundamental transformation in the research model, evolving from the traditional single-virus species identification to the multi-omics integrated analysis of virus-host interaction networks. It is worth noting that the existing research shows a distinct feature of "imbalance between dry and wet experiments". Most of the achievements are based on bioinformatics analysis, while the translational medicine research involving virus isolation, culture and functional verification is still in its infancy (accounting for only 25%), especially the mechanism research evidence chain for key scientific issues such as the viral-host molecular interaction mechanism has not yet been completed.
    CONCLUSION: The progress of enterovirus group research is developing rapidly. However, the species-level taxonomy of a large proportion of newly discovered bacteriophages remains unresolved. Future research must give priority to establishing a comprehensive functional database, and at the same time combine the systematic characterization of viral functions with the study of the mechanism of host-virus interaction to enable bacteriophages to play a role in maintaining human health.
    Keywords:  Bibliometrics; Gut Virome; Hotspot Analysis; Phage therapy; Theme Evolution
    DOI:  https://doi.org/10.1186/s12985-025-02856-x
  68. Telemed J E Health. 2025 Jul 10.
      Introduction: Telemedicine research in France remains relatively underexplored, with a notable absence of comprehensive literature reviews or bibliometric analyses guiding research prioritization and funding allocation for public health interests. The objective of this study is to provide a comprehensive overview of telehealth research in France, elucidating its current trends and primary funding sources. Methods: A bibliometric analysis was conducted spanning a 20-year period from January 1, 2004, to December 31, 2023, using six open-access databases, including the Ministry of Health of France (public research funding), Health Data Hub (research protocols from France), Clinicaltrials.gov (global repository of research protocols), PubMed (scientific publications), Theses.fr (PhD database in France), and DUMAS (master's and doctorate theses database in France). Results: The French Ministry of Health funded 41 telehealth research projects between 2009 and 2022, amounting to €15 million, which constituted 1.1% of all projects funded during this period. 279 study protocols were identified on ClinicalTrials.gov, peaking in 2021 with 58 protocols (20.8%), representing 5.8% of worldwide protocols. Public hospitals provided most of the funding (66%), with 18% coming from the industry. A total of 1,254 publications related to telehealth were identified in PubMed, representing 2.5% of worldwide telehealth publications. Discussions: This is the first study in France and Europe to describe the trends in telehealth research over a 20-year period. Telehealth research in France started in the early 2000s, had a linear growth between 2011 and 2021, peaked during the COVID-19 pandemic, and decreased in 2022 and 2023. All types of telehealth interactions were covered, and funding came mostly from public sources. Funding for telehealth research was however limited and should be increased in France.
    Keywords:  tele-expertise; teleconsultation; telehealth; telemedicine
    DOI:  https://doi.org/10.1089/tmj.2025.0078
  69. Int J Eat Disord. 2025 Jul 09.
      A review and bibliometric analysis on the last five decades of eating disorders (EDs) research by Lee and Chi (2025) reports a generally weak connection between public attention and academic citations. The authors suggest a few potential reasons for this phenomenon, including that public interest may not reflect long-term scientific value. We use a public health policy perspective to offer an alternate argument: that public attention and engagement, alongside scientific rigor, are necessary to move the ED field forward and generate substantive policy change. We discuss how research topics that resonate with the public, such as less commonly represented EDs or EDs among under-represented populations, can lead to decreases in stigma and support the early identification of symptoms among the population. Drawing on the ideas of strategic science, we stress the importance of intentionally linking academic work to policy by conducting research that is relevant to decision-makers as well as the broader public, working within multi- and trans-disciplinary teams, and training researchers, especially those in early career positions, on how to conduct policy-relevant research. The synergism of public engagement with research and scientific impact can be a powerful force for moving the ED field forward.
    Keywords:  altmetrics; eating disorders; public health; public policy; strategic science
    DOI:  https://doi.org/10.1002/eat.24500
  70. Biogerontology. 2025 Jul 08. 26(4): 140
      Cell cycle regulation, aging, and metabolism are pivotal biological processes linked to both normal physiology and disease development. Understanding their interplay is crucial for advancing gerontological research and clinical oncology. We analyzed articles and reviews on the cell cycle, aging, and metabolism from 2004 to 2023 using the Web of Science Core Collection. Bibliometric tools, VOSviewer, and CiteSpace, were applied to visualize collaboration networks, geographic distributions, and thematic clusters. Our analysis of 698 papers highlights a growing interest in the intersection of all three of these topics, with a notable publication surge from 2019 to 2022. The United States and China emerged as leading contributors, with significant international collaborations. Research themes evolved around molecular mechanisms, oxidative stress, and the implications for neurodegenerative diseases and cancer. Furthermore, keyword analysis identified five key clusters: neurodegenerative biomarkers, oxidative damage, cell cycle disruptions in cancer, epigenetic links between aging and cancer, and metabolic stress responses. Notably, metabolic shifts associated with aging influence both cellular repair mechanisms and the onset of senescence, indicating a transition from macroscopic changes to microscopic molecular alterations. This bibliometric study systematically maps the scholarly output on the cell cycle, aging, and metabolism, and our findings underscore the importance of molecular and genetic research in understanding the complex interactions and highlight their translational potential in oncology. Future research should explore personalized tumor treatment strategies based on individual cell cycle dynamics and genetic profiling.
    Keywords:  Aging; Bibliometric analysis; Cell cycle; Cellular senescence; Metabolism
    DOI:  https://doi.org/10.1007/s10522-025-10271-6
  71. Front Psychol. 2025 ;16 1604108
      Sports associations and companies share a common goal of identifying and selecting top talent, prompting a growing interest in refining their selection processes. Recent decades have witnessed increased attention to predictive valid constructs (e.g., motivation) and predictive assessment methods (e.g., questionnaires). Leveraging an extensive history and empirical evidence from personnel selection research in business, a cross-contextual knowledge transfer could offer potential benefits for both sports and business. To examine the utilization of information between sports and the business context, this study explores the connection between these contexts. Analyzing 20,492 articles from SCOPUS and Web of Science databases, we followed PRISMA guidelines and conducted a citation network analysis (n = 940 articles). Results reveal limited interconnectivity (3,728 links), with only six articles cited between contexts: three sports articles cited business articles and vice versa. Sports articles referred to business research for talent definition, skill assessment, and methodological concerns. Contrarily, the business domain primarily used sports research as examples and for individual aspects of talent development models. This study highlights the potential for points of connection, including requirement analysis, skill assessment, and research on predictive validity. Future research should systematically explore shared and underrepresented topics in both contexts, such as the use of, for example, situational judgement tests in sports to enhance talent selection in sports, drawing insights from the business domain.
    Systematic review registration: https://aspredicted.org/366x-7cfd.pdf.
    Keywords:  CNA; bibliometric study; interdisciplinarity; personnel selection; talent identification
    DOI:  https://doi.org/10.3389/fpsyg.2025.1604108
  72. Account Res. 2025 Jul 05. 1-23
      Background: The rising number of academic retractions has drawn increasing attention across the academic community. With the availability of large-scale retraction data from Crossref and Retraction Watch, systematic analysis of academic retractions has become feasible.Methods: This study examines all retracted academic publications from the 21st century up to June 4th, 2025. By using BERTopic, Apriori, and data visualization techniques, we've conducted a comprehensive analysis across six subjects with over 6,000 retractions of each subject.Results and conclusions: Our findings detail retraction counts, durations, topic trends, author nationalities, publishers, retraction reasons, and associations among these factors. The overall number of retractions has been continuously rising, with sharp increases in 2010 and 2020 to 2023, and the peak occurring in 2023. The primary reasons for retractions in biomedical studies are paper mills and issues with data and images, with third parties being the main initiators of investigations. In computer science and technology, retractions are mainly due to referencing and attribution issues, as well as unreliable results, with journals, conferences, and publishers often initiating the investigations. We also offer some suggestions that can help monitor research misconduct in academic publications.
    Keywords:  BERTopic; Retraction; academic misconduct; data visualization; scientometrics
    DOI:  https://doi.org/10.1080/08989621.2025.2528064
  73. Bull Volcanol. 2025 ;87(8): 60
      Volcanoes are not randomly located on Earth, neither are volcanologists. We explored the physical distance between volcanologists and volcanoes by considering two categories of volcanoes: all volcanoes with a confirmed eruption in the Holocene and volcanoes that erupted in the past 50 years (1974-2024). We computed the distance between these volcanoes and the affiliation addresses from volcanologists, defined here as authors having published in the main volcanology journals. We then investigated the dependence of this distance on further bibliometric parameters, such as the journal published in or the author position. Affiliations were extracted from articles published since 1980 in four of the main English-speaking volcanology-focused journals in the Scopus database. Around 27% of volcanologists are based within 100 km of a Holocene volcano, compared to 14% of the world population. More than 85% of volcanologists are within 1000 km of a Holocene volcano, but 48% need to travel over 1000 km to visit a volcano that erupted in the past 50 years. We tested whether distance to the nearest volcano correlates with author position. We observed that researchers working nearer volcanoes tend to lead articles with more co-authors, which is robustly supported by statistical tests. We also found that authors in further positions tend to be based nearer recently active volcanoes, though this correlation is less significant. Using keywords to identify each article's studied volcano, we performed single volcano analysis for the 25 most frequently studied volcanoes in the dataset. We observed significant differences in the distance from authors to the target volcano. For instance, we obtained median author-volcano distances of 9 km for Campi Flegrei and 11,735 km for Merapi. Our analyses also permitted a very simplistic estimate of the carbon footprint from fieldwork travel, yielding CO 2 equivalent emissions of about 1 ton per travelling author, with an order of magnitude uncertainty. The database presented is very rich and could serve future efforts in science strategy, equality, diversity and inclusivity, outreach, and sustainability.
    Supplementary Information: The online version contains supplementary material available at 10.1007/s00445-025-01849-6.
    Keywords:  Bibliometrics; Carbon footprint; Distance; Statistics; Volcanoes; Volcanologists
    DOI:  https://doi.org/10.1007/s00445-025-01849-6
  74. Can J Anaesth. 2025 Jul 07.
      
    Keywords:  academic anesthesiology; gender equity; representation; research authorship
    DOI:  https://doi.org/10.1007/s12630-025-03017-y
  75. Bioinformation. 2025 ;21(4): 587-593
      Telemedicine is becoming a transformative tool for managing chronic diseases. Known literature data emphasizes the effectiveness and accessibility of telemedicine and its impact on patient outcomes. Thus, the foundation for advancing the role of telemedicine in chronic disease management for improving healthcare accessibility and quality of life is imperative.
    Keywords:  Telemedicine; bibliometric analysis; chronic disease management; global research trends; healthcare accessibility; research impact; telehealth innovation
    DOI:  https://doi.org/10.6026/973206300210587
  76. Cureus. 2025 Jun;17(6): e85716
       INTRODUCTION: Over the last several decades, the number of women in ophthalmology has gradually increased. However, studies have demonstrated that far fewer women than men are represented in senior leadership positions. Having an endowed chair facilitates career influence through support for research, service, and teaching activities and is considered one of the most prestigious academic awards that an institution for a faculty member can grant. We explore the relationship between endowed chair status and a variety of characteristics among ophthalmology faculty at 41 major institutionsacross the United States (U.S.).
    METHODS: All 41 ophthalmology hospitals listed in US News and World Report's 2022 Best Hospitals for Ophthalmologywere included. Endowed chair status, gender, number of academic titles, US News rank of institution, region of the U.S., graduate degree, professor status, and ophthalmic subspecialty were collected using publicly available information. Univariable analysis compared the odds of having an endowed chair for subgroups of the studied variables. Multivariable logistic regression determined the odds of having an endowed chair after controlling for other variable effects.
    RESULTS: A total of 860 (38%) women and 1,402 (62%) men ophthalmologists were identified. Of these, 246 (10.9%) carried endowed chair titles, of whom 59 (24%) were women. On univariable analysis, being male (p<0.001), greater number of titles (p<0.001), location in the South (p<0.001), PhD degree (p=0.026), full professor status (p<0.001), and uveitis/retina specialization (p<0.001) had significant associations with endowed chair status. Compared with comprehensive ophthalmologists, most ophthalmic subspecialists had greater odds of endowed chair status (p<0.05). On multivariable analysis, all variables had a significant association with endowed chair status (p<0.001) except for gender (p=0.111).
    CONCLUSION: After controlling for other variables, holding two or more additional titles, location in the South, PhD degree, uveitis/retina specialization, and holding a full professorship were significantly associated with greater odds of holding an endowed chair across U.S. academic ophthalmology institutions. Gender had a significant association with endowed chair status on univariable but not multivariable analysis; however, more men than women had characteristics that this study found to be associated with endowed chair status.
    Keywords:  academic ophthalmology; endowed chair; faculty titles; gender disparities; geographic variation; leadership in medicine
    DOI:  https://doi.org/10.7759/cureus.85716
  77. Cleft Palate Craniofac J. 2025 Jul 10. 10556656251357423
      ObjectiveWe strive to analyze Cleft Lip and Palate repair (CLP) from low-and-middle income countries (LMICs) and understand authorship patterns between different countries.DesignFive high-impact journals were selected for analysis from 2008 to 2024. Articles were initially screened to determine if the study focused on a LMIC according to the World Health Organization and if the study's subject was CLP.SettingOur study involved reviewing papers from multiple levels of clinical care.Patients, ParticipantsWe categorized the selected studies by their stated diagnoses (cleft lip, cleft palate, CLP, velopharyngeal insufficiency, and other).InterventionsSpecific interventions were not recorded due to the nature of the study.Main Outcome Measure(s)Nationality and gender of first author, nationality and gender of senior author, and country income status (based on World Health Organization classification).ResultsMost first authors were male (54%) and from upper-middle-income countries (69%). Kappa scores showed significant agreement for country income classification and the income classification of the country of the first author (K = 0.779, P < .01). There was minimal change in the representation of LMICs over the study's time period (b = -0.0017, SE = 0.008, P = .8429). There were 9 low-income country articles but only 1 (11%) had first author from the represented country.ConclusionsOverall, authors from middle-income countries are well-represented in CLP articles from their countries, but not the case for low-income country authors. Continued scrutiny of equitable publication should be conducted as low-income countries continue to be underrepresented in the literature.
    Keywords:  authorship; cleft lip and palate; global health
    DOI:  https://doi.org/10.1177/10556656251357423
  78. PLoS One. 2025 ;20(7): e0327793
      Understanding the internal structure of scientific discourse is essential for tracking the evolution of research topics and their conceptual interdependencies. However, existing approaches such as dynamic topic modeling and neural topic models often fail to capture fine-grained semantic shifts among known concepts, or require substantial computational resources. Co-occurrence networks offer a more interpretable alternative, but typically rely on correlation-based weights that lack metric properties, preventing rigorous temporal comparison and topological interpretation. To address this gap, we introduce a metric-based framework for analyzing the evolving structure of concept networks in the scientific literature. Using 10,370 research articles (2010-2023) on international security from JSTOR and PORTICO, we compute the normalized variation of information (NVI) distances to construct annual concept networks with a well-defined geometric structure. We then quantify semantic change using velocity matrices and extract major trends using Minimum Spanning Tree (MST) analysis. Our results reveal that conceptual shifts are concentrated in temporally localized hubs and are not driven by co-occurrence frequency alone, but by contextual information and shared uncertainty between concept distributions. By introducing a scalable, interpretable, and mathematically grounded approach to tracking concept dynamics, this study contributes new tools for topic evolution analysis and offers insight into the structural organization and reconfiguration of knowledge over time.
    DOI:  https://doi.org/10.1371/journal.pone.0327793
  79. Can Urol Assoc J. 2025 Jul 08.
       INTRODUCTION: Women are underrepresented in Canadian urology, particularly within academic leadership. This study aimed to analyze gender differences and trends in Canadian Urological Association (CUA) guideline authorship.
    METHODS: We searched the Canadian Urological Association Journal from March 2007 to August 2024 for all versions of eligible guidelines, best practice reports, and consensus statements. Two independent reviewers extracted data in duplicate. Authors appearing in multiple guidelines were counted more than once. We analyzed author characteristics by gender using the Chi-square test and assessed authorship over time using the Cochran-Armitage test for trend.
    RESULTS: There were 1172 non-unique authors across 112 guidelines, of whom 750 (64%) were urologists. Women represented 15.5% of all authors and 7.5% of urologist authors. Focusing only on urologists, women were more likely to be first authors and to be included on functional, pediatric, and endourology guidelines than men. The proportion of women urologist authors, first authors, and last authors did not change significantly over time. Men and women urologists had similar rates of repeated authorship (56.7% vs. 51.7%, p=0.61), although men were more likely to appear on ≥5 guideline panels (23.6% vs. 6.9%, p=0.04).
    CONCLUSIONS: CUA guideline authorship is dominated by men, with limited progress in the participation of women over the past 18 years. CUA guideline panels help establish the standard of urologic care, and guideline authorship represents a significant academic opportunity. Further work to minimize this gender disparity is needed to ensure our guidelines better reflect the diversity of Canadian urologists, urology trainees, and patients.
    DOI:  https://doi.org/10.5489/cuaj.9155
  80. Trop Med Health. 2025 Jul 11. 53(1): 92
       BACKGROUND: Shaped by its colonial origins, tropical medicine sustains inequitable power dynamics in global health, sidelining low-middle-income countries (LMICs) in critical decision-making processes over research agendas and priorities. Editorial boards of tropical medicine journals, dominated by scholars from high-income countries (HICs), risk reinforcing power imbalances and excluding context-driven expertise from endemic regions. This study examines the diversity of editorial boards across gender, geographic, socioeconomic, and geopolitical dimensions to assess systemic inequities.
    METHOD: A systematic search of the National Library of Medicine (NLM) catalog was conducted via a targeted strategy between October and December 2024. After screening 153 journals for title relevance and applying exclusion criteria based on publication status, availability of editorial information, and global scope, 24 journals were selected. Data on 2,226 editorial board members were extracted from journal and institutional websites. Data on gender, country of affiliation (classified by World Bank income/regions), and geopolitical groups (G7, G20, BRICS) were extracted from public sources. Gender determination used a sequential approach (journal descriptions, Genderize.io, and consensus). Descriptive statistics were used to perform the analysis.
    RESULTS: The editorial board comprised 2,226 members, 66% male, 31.2% female, and 2.8% undetermined, from 120 nations. The regional contributions included Europe and Central Asia (21.9%), North America (20.9%), East Asia and the Pacific (16.6%), and Latin America and the Caribbean (16.2%), whereas Sub-Saharan Africa (11.2%), South Asia (9.7%), and the Middle East and North Africa (3.4%) were underrepresented. Over half (52.8%) were affiliated with high-income countries. Geopolitically, 40.3% were from the G7, 67.1% were from the G20, and 24.2% were from the BRICS. Some journals showed skewing, with 85.2% North American representation and 90.3% East Asia-Pacific dominance.
    CONCLUSION: Tropical medicine editorial boards are steeped in systemic inequities that echo colonial legacies, with the overrepresentation of HICs and men limiting LMIC perspectives and local expertise. This imbalance undermines research relevance and ethical integrity by prioritizing Global North agendas over the needs of populations most affected by tropical diseases. To address these disparities, substantial reforms are essential. Strategies such as instituting DEI (Diversity, Equity and Inclusion), creating targeted mentorship programs for LMIC researchers, and enforcing transparent, bias-resistant recruitment practices are important. Such measures will create a more inclusive editorial landscape that aligns research priorities with global health needs, promoting equitable and contextually relevant solutions.
    Keywords:  DEI; Editorial boards; Global health and journals; Tropical diseases
    DOI:  https://doi.org/10.1186/s41182-025-00752-2
  81. Cardiol Rev. 2025 Jul 07.
      Research plays a significant role in the residency match, particularly after the United States Medical Licensing Examination Step 1 changed from a score-based exam to pass/fail scoring. This study shows the impact of research on the match between 2009 and 2024, categorized by specialties and residency competitiveness. Residency specialties were categorized according to competitiveness (high, medium, and low), according to the Association of American Medical Colleges. The data were analyzed using descriptive statistics, paired-samples t-test, two-way repeated measures analysis of variance, and post hoc pairwise comparisons with Bonferroni correction to examine differences in research experiences and outputs across specialties. The total number of US senior applicants increased from 14,697 in 2009 to 18,801 in 2024, with US-matched applicants rising from 13,453 to 16,891. The overall match rate did not significantly change. Research experiences and outputs significantly increased, with the mean number of research experiences rising 180% (2.44-4.38; P < 0.001) and publications 365% (3.82-13.98; P < 0.001). Analysis of variance showed that highly competitive specialties had the largest increases in both research experiences, 195% (3.03-5.92; P < 0.001) and publications, 405% (5.46-22.14; P < 0.001). Our study showed that research has become increasingly essential to the match, particularly in highly competitive specialties. Our findings illustrate the key priorities in residency applications and demonstrate the expanding importance of research within the match.
    Keywords:  publication; publication numbers; research experience; residency application
    DOI:  https://doi.org/10.1097/CRD.0000000000000978