bims-evares Biomed News
on Evaluation of research
Issue of 2025–05–25
97 papers selected by
Thomas Krichel, Open Library Society
  1. Global trends in endometrial cancer and metabolic syndrome research: A bibliometric and visualization analysis.
  2. Randomized control trial in nursing education: A bibliometric analysis and visualization.
  3. Research hotspots and emerging trends in targeted therapy for colorectal cancer: a bibliometric analysis (2000-2023).
  4. Tracing global progress: two decades of age-related macular degeneration research.
  5. Global research status and frontiers on ferroptosis in hepatocellular carcinoma: a comprehensive bibliometric and visualized analysis.
  6. The Research Trend of Non-surgical Rhinoplasty: A Bibliometric and Visualized Analysis.
  7. Trends in research on preterm birth in twin pregnancy based on bibliometrics.
  8. Global trends and hotspots in the learning curves of robotic-assisted surgery: a bibliometric and visualization analysis.
  9. Global research trends of peripheral nerve surgery: a bibliometric and visualized analysis.
  10. Global Research of Medical Technology Management: A Bibliometric Analysis.
  11. Evolution Trend of Brain Science Research: An Integrated Bibliometric and Mapping Approach.
  12. Research Trends on Nanomaterials and Hepatocellular Carcinoma From 1999 to 2024: A Bibliometric Analysis.
  13. Research hotspots and trends of sarcopenia in orthopaedic surgery: a bibliometric analysis from 2003 to 2023.
  14. The Status and Future Directions of Treatments for Polyglutamine Spinocerebellar Ataxia: A Bibliometric and Visual Analysis.
  15. Research development of teachers' emotional intelligence in the 21st century: A bibliometric analysis.
  16. Global research trends and hotspots in erysipelas: a bibliometric analysis from 2000 to 2024.
  17. Publications of systematic review and meta-analysis in the indexed anesthesia journals: a 10-year bibliometric analysis.
  18. Research trends in the field of sport impact on the economy: a bibliometric analysis.
  19. Therapeutic hypothermia for neonates: a bibliometric analysis and visualization research.
  20. Bibliometrics and Visualization Analysis of Neuromuscular Junction Model.
  21. Authorship analysis of publications in Naunyn-Schmiedeberg's Archives of Pharmacology (1969-2024).
  22. Current trends and landscape of drug resistance in renal cell carcinoma: a bibliometric analysis.
  23. A Bibliometric Analysis of the 100 Most-Cited Articles on Soccer Injuries.
  24. Research progress and hotspots of the impact of Mediterranean diet on aging from 2004 to 2023: A bibliometric analysis.
  25. A Comprehensive Bibliometric Study on Silicone Implants: From Aesthetics to Prosthetics and Augmentation.
  26. Global trends and developments in pulmonary magnetic resonance imaging research: a bibliometric analysis of the past decade.
  27. Trends in Research on Gantenerumab for Alzheimer's Disease: A Bibliometric and Thematic Analysis.
  28. Global trends and hotspots in diabetes and obesity research: A bibliometric analysis.
  29. Bibliometric analysis of the S24-7 family and its association with health.
  30. Bibliometric analysis of hotspots in Staphylococcus aureus drug resistance research.
  31. Visualization analysis of ovarian hyperstimulation syndrome based on bibliometrics.
  32. Academic Output of Anesthesiology Departments in Canada From 2014 to 2023: A Bibliometric Analysis Study.
  33. Research Trends and Structural Characteristics of Healthcare Research in Japan, Including the First Half of the New Coronavirus Spread Period: A Bibliometric Analysis.
  34. Bibliometric Analysis of the 40-Year History of Public Health Nursing (1984-2024).
  35. Research trends in CAR-T cell therapy: A comprehensive bibliometric analysis highlighting cardiovascular toxicity and clinical implications.
  36. Frontiers and knowledge map of macrophage in wound healing: a scientometric and visualization analysis.
  37. Bibliometric visualization of hepatocellular carcinoma and metabolic syndrome research: trends and emerging areas.
  38. Worldwide research on abdominal compartment syndrome: bibliometric analysis of scientific literature (1993-2022).
  39. A bibliometric analysis of malignant pleural mesothelioma from 2010 to 2023.
  40. Research trends of facial nerve injury after cerebellopontine angle tumor: CiteSpace-based bibliometric analysis.
  41. A Bibliometric Analysis of COVID-19 Publications Between January 2019 and February 2025 by Romanian Authors.
  42. Bibliometric analysis of the application of artificial intelligence in orthopedic imaging.
  43. Application of Machine Learning and Emerging Health Technologies in the Uptake of HIV Testing: Bibliometric Analysis of Studies Published From 2000 to 2024.
  44. Bibliometric analysis of current trends and emerging patterns in the application of nanomaterials for non-small cell lung cancer.
  45. AI-Powered Affiliation Insights: LLM-Based Bibliometric Study of European Medical Informatics Conferences.
  46. A bibliometric analysis of the literature published on autophagy, ferroptosis, necroptosis, and pyroptosis in cardiovascular disease from 2009 to 2023.
  47. GABAergic receptors and essential oils in anxiety and depression: a scientometric analysis.
  48. Effectiveness of herbal medicine for liver cancer treatment as revealed by a bibliometric and visualization analysis.
  49. Bibliometric analysis of hepatocellular carcinoma and tyrosine kinase inhibitors.
  50. Current status and trends of machine learning applied in clinical research of gastric cancer from 2004 to 2023: global bibliometric and visual analysis.
  51. Current status and future prospects of microalgae-based degradation of spent lubricant oil hydrocarbon towards environmental sustainability: a mini review and bibliometric analysis.
  52. Publication Volume and Equity in Competitive Surgical Residency Programs: A Bibliometric Analysis of the 2023-2024 Match.
  53. Citations of retracted articles will no longer count towards impact factor.
  54. Thyroid Eye disease in the Biologic Era: a 40-year paradigm shift in nonsurgical therapeutic strategies.
  55. A bibliometric analysis of the current state of research on family interventions for ASD.
  56. Studying the Role of Vegetarianism as a Potential Strategy for Cancer Prevention and Treatment, a Bibliometric Analysis.
  57. A comprehensive bibliometric analysis of the association between atopic dermatitis and depression (1994-2024).
  58. Knowledge landscape of macrophage research in liver fibrosis: a bibliometric review of the literature from WoSCC.
  59. Female authorship trends in a high-impact Canadian medical journal: a 10-year cross-sectional series, 2013-2023.
  60. The role of programmed cell death in renal cancer: a bibliometric perspective (1998-2024).
  61. A bibliometric and visualized analysis of ischemic optic neuropathy from 2014 to 2024.
  62. Mapping the landscape: A bibliometric analysis of AI and teacher collaboration in educational research.
  63. Bibliometric analysis of traditional Chinese medicine in cancer treatment via immune system modulation (2015-2025).
  64. Plastic Surgery Research From Low- and Middle-income Countries Over a Decade: A Web of Science Analysis.
  65. Prescription Digital Therapeutics Research Across Clinical, Engagement, Regulatory, and Implementation Domains: A Bibliometric and Thematic Study.
  66. Bibliometric and visual analysis of retinal fibrosis research from 1993 to 2023.
  67. Visualization analysis of poisoning-related research based on CiteSpace.
  68. Trends in Research on the P2X7 Receptor: A Bibliometric and Visualization Analysis.
  69. Metabolic syndrome and bladder cancer risk: a comprehensive evidence synthesis combining bibliometric and meta-analysis approaches.
  70. Production and impact of Italian researchers in physical-Sport education and sport pedagogy.
  71. Bibliometric Analysis of Small-Cell Lung Cancer in Geriatric Populations.
  72. Scopus Indexing Delays of Articles Published in Major Pharmacy Practice Journals.
  73. Bibliometric analysis of tumor marker application in gastric cancer diagnosis from 2019 to 2024.
  74. Editorial: Neutrophil extracellular traps (NETs) triggered by helminths and protozoan parasites.
  75. Bibliometric insights into breast cancer organoid chips: trends & emerging areas.
  76. A commentary: "Global trends in surgically based treatment of anal fistula in Crohn's disease: a bibliometric and visualization analysis".
  77. Over 70 Years of Neurosurgical Research: A Comparison of the Publication Performance of Two Leading Journals: "Acta Neurochirurgica" and "Zentralblatt für Neurochirurgie".
  78. Twenty-year panoramic review of stem cells research in kidney diseases (2005-2025): a bibliometric and clinical trial-based exploration.
  79. Closing the publishing gender gap in economics and political science: Does a critical mass matter?
  80. Multidimensional excavation of the current status and trends of mechanobiology in cardiovascular homeostasis and remodeling within 20 years.
  81. Outcomes of Foundational Learning in Research Methods Following Primary Medical Qualification on Surgical Research: A Retrospective Review.
  82. Comments on "Peripheral nerve blocks for hip fracture surgeries: a bibliometric and visual analysis".
  83. The critical role of persistent disruption in advancing science.
  84. LITERAS: Biomedical literature review and citation retrieval agents.
  85. The positioning of policy documents in the field of health policy and systems research.
  86. Tetramethylpyrazine in Vinegar: A Bibliometric Analysis and Synthetic Mechanism.
  87. Who are the Hybrid Ceramics? Bibliometric Review.
  88. Membership in team science institute enhances diversity of researchers' collaboration networks.
  89. Factors Associated with Academic Promotion Among US Academic Dermatologists.
  90. Bibliometric guides to early physical exercise, education, and rehabilitation (PEER) research on girls and women.
  91. Genes and Environment: reflections on its journey, past and future.
  92. Global trends and perspectives in nanochitin research: A comprehensive review of types, properties, applications, and scientometric analysis.
  93. Review on research methods of the surface urban heat island effect based on CNKI bibliometrics.
  94. The Value of Research in the Orthopaedic Surgery Residency Applicant: A Pilot Survey of Orthopaedic Surgery Residency Program Directors.
  95. Machine learning-based text mining for cutaneous myiasis and potential value of an accidental maggot therapy for complicated skin and soft tissue infection with sepsis.
  96. Understanding the Mechanism of Cardiotoxicity Induced by Nanomaterials: A Comprehensive Review.
  97. Career Paths After Microsurgery Fellowship: A 10-Year Analysis.
  1. Comput Biol Med. 2025 May 15. pii: S0010-4825(25)00713-9. [Epub ahead of print]192(Pt B): 110362
    Global trends in endometrial cancer and metabolic syndrome research: A bibliometric and visualization analysis.
    Xiaoqiang Pan, Jiajia Li, Panbo Liu, Jin Li, Mingyue Zhao, Yulun Wu, Shuyu Ji, Tong Ren, Qiuhua Jiang, Songling Zhang.
       BACKGROUND: Currently, many studies have shown that there is a link between metabolic syndrome (MetS) and endometrial cancer (EC). However, there has been no systematic bibliometric analysis of related publications, which limits the comprehensive understanding of research trends and priorities. Our study makes up for this problem.
    OBJECTIVE: Through bibliometric analysis, this study aimed to reveal key research focus areas, developmental trends, and major contributors of EC and MetS.
    METHODS: The literature for this study was obtained from the Web of Science Core Collection (WoSCC) through August 31, 2024. We searched for EC and MetS using subject and free terms. Microsoft Office Excel 2016, CiteSpace, and VOSviewer software packages were used for bibliometric analysis, considering specific characteristics such as year of publication, country, institution, authorship, journal, references, and keywords.
    RESULTS: A total of 367 publications were included. Annual publications exhibited exponential growth (R2 = 0.8282), indicatingsustained interest in the field. The United States (111 publications), China (80), and Italy (38) were the most productive countries. The University of California System led institutional contributions. Keyword co-occurrence and burst analysis revealed that obesity (occurrence: 113; link strength: 630), insulin resistance (112; 587), and polycystic ovary syndrome (83; 386) were the most frequent and interconnected research foci. Emerging trends, identified through keyword time-zone mapping (average citation year: 2015-2019), highlighted weight control and bariatric surgery as novel interventions. Journals with the highest impact included ∗Fertility and Sterility∗ (IF: 6.6) and ∗International Journal of Epidemiology (IF: 6.4).
    CONCLUSIONS: This study conducted a preliminary bibliometric and visual analysis of the EC and MetS research literature, revealing trends, global cooperation models, fundamental knowledge, and emerging frontiers of EC and MetS. For over 30 years, research has mainly focused on the correlation between MetS and EC, disease factors, prognosis, prevention, and other aspects that have guiding significance for public health.
    Keywords:  Bibliometric; CiteSpace; Endometrial cancer; Metabolic syndrome; VOSviewer
    DOI:  https://doi.org/10.1016/j.compbiomed.2025.110362
  2. Nurse Educ Pract. 2025 May 11. pii: S1471-5953(25)00150-7. [Epub ahead of print]86 104394
    Randomized control trial in nursing education: A bibliometric analysis and visualization.
    Esin Ateş, Ebru Konal Korkmaz.
       AIM: The aim of this study was to examine randomized controlled trials in nursing education using bibliometric analysis.
    METHODS: Descriptive and bibliometric analyses were used. Web of Science database was used to determine the most frequently cited studies of nursing education randomised controlled trials, the most influential journals in this field, trends and trends of studies. Bibliometric analysis and visualisation were performed using VOSviewer and Bibliometrix Package in R software.
    RESULTS: In the study, a total of 141 publications were published in 29 different sources between 2007 and 2025. The most influential journal where the studies were published was Nurse Education Today (n = 53). In the studies, 405 author keywords belonging to 623 authors were found. The most frequently used author keywords were 'simulation (n = 18)', 'knowledge (n = 8)', 'simulation training (n = 8)', 'learning (n = 7)' and 'anxiety (n = 6)'. It was found that the most frequently used trend topics in the early years were 'attitudes', while in recent years, trend topics such as 'simulation', 'knowledge' and 'skills' have become popular.
    CONCLUSION: The number of randomized controlled trials in nursing education has been on the rise in recent years. The findings of this study will contribute to the advancement of nursing education literature and inform future scientific studies by addressing existing gaps in knowledge in this field.
    Keywords:  Bibliometrics analysis; Nursing education; Nursing students; Randomized control trial
    DOI:  https://doi.org/10.1016/j.nepr.2025.104394
  3. Discov Oncol. 2025 May 16. 16(1): 789
    Research hotspots and emerging trends in targeted therapy for colorectal cancer: a bibliometric analysis (2000-2023).
    Xiangnv Meng, Zhongting Lu, Fu Mi, Sha Sha, Tao Li.
       BACKGROUND: Targeted therapy has significantly transformed the treatment landscape of colorectal cancer (CRC), enabling personalized treatment approaches and improving patient prognosis. This study employs bibliometric analysis to explore the research hotspots and development trends in the field of CRC-targeted therapy from 2000 to 2023.
    METHODS: Based on the Web of Science Core Collection, this study collected literature related to CRC-targeted therapy published between 2000 and 2023. CiteSpace and VOSviewer were used for data analysis, with a focus on publication trends, key contributors, and keyword co-occurrence patterns.
    RESULTS: A total of 2252 relevant articles were included, demonstrating a steady growth trend in research output. China ranked first in terms of the number of publications, while the University of Texas MD Anderson Cancer Center was identified as the institution with the highest research output. Josep Tabernero was the most prolific author in this field. Among journals, Cancers had the highest impact, while Clinical Cancer Research held a significant advantage in citation frequency. Keyword co-occurrence and clustering analysis indicated that research primarily focused on treatment strategies and precision medicine, with emerging technologies such as cell therapy and liquid biopsy garnering increasing attention.
    CONCLUSION: This study reveals the research trends, core hotspots, and emerging directions in the field of CRC-targeted therapy, providing valuable insights for future research.
    Keywords:  Bibliometric analysis; Colorectal cancer; Data visualization; Targeted therapy
    DOI:  https://doi.org/10.1007/s12672-025-02632-x
  4. Int J Ophthalmol. 2025 ;18(5): 925-936
    Tracing global progress: two decades of age-related macular degeneration research.
    Li-Yun Yuan, Liang-Pin Li, Xia Hua, Xiao-Yong Yuan.
       AIM: To conduct a comprehensive bibliometric analysis of age-related macular degeneration (AMD) research from 2002 to 2022, identifying key contributing countries, institutions, authors, journals, and research hotspots to inform future research directions.
    METHODS: Publications related to AMD were retrieved from the Web of Science Core Collection (WoSCC) database for the period January 1, 2002, to December 31, 2022. The search was limited to English-language articles and reviews. Bibliometric analysis was performed using Microsoft Excel 2021 for data management and annual publication analysis. Visualization and network analyses were conducted using VOSviewer, CiteSpace, and the Bibliometrix package in R. Collaboration networks among countries, institutions, authors, and journals were mapped. Keywords were analyzed for co-occurrence to identify research hotspots. Metrics such as H-index, total link strength (TLS), and citation counts were used to assess impact.
    RESULTS: A total of 16 715 publications were analyzed, showing a consistent increase in AMD research output over the past 20y, peaking at 1445 publications in 2021. The United States was the leading contributor with 31.8% of total publications, followed by China and the United Kingdom. The University of Melbourne emerged as the most productive institution with the highest TLS, indicating strong international collaborations. Professor Frank G. Holz was identified as the most influential author based on H-index and publication count. Investigative Ophthalmology & Visual Science was the most prolific journal and had the highest citation impact. Keyword co-occurrence analysis revealed four main research clusters: pathogenesis, therapy, epidemiology, and diagnosis. Emerging research hotspots included anti-vascular endothelial growth factor (VEGF) therapies, optical coherence tomography angiography, and artificial intelligence (AI) applications in diagnosis.
    CONCLUSION: The bibliometric analysis highlights significant growth and collaborative efforts in AMD research globally. Key contributors have advanced understanding in pathogenesis, therapeutic strategies, epidemiology, and diagnostic technologies. Future research should focus on interdisciplinary collaborations, novel therapeutic targets, personalized medicine, and technological innovations such as AI to effectively address the challenges posed by AMD.
    Keywords:  age-related macular degeneration; bibliometric analysis; collaboration networks; research hotspots; research trends
    DOI:  https://doi.org/10.18240/ijo.2025.05.20
  5. Front Immunol. 2025 ;16 1549600
    Global research status and frontiers on ferroptosis in hepatocellular carcinoma: a comprehensive bibliometric and visualized analysis.
    Jiayu Zhu, Shengping Luo, Fei Yu, Kewei Sun.
       Objective: The purpose of this study was to analyze the research hotspots and future trends in the field of ferroptosis in hepatocellular carcinoma in the past 10 years by using bibliometrics and visualization software, and to provide reference for future research directions in this field.
    Methods: The Web of Science database was searched from January 1, 2012, to October 30, 2024, and the annual publication volume, countries, institutions, journals, authors, references, keywords, and other information in this field were analyzed by bibliometrics, VOSviewer, and CiteSpace.
    Results: A total of 645 English articles from 729 institutions in 32 countries were included in this study, with 4545 authors published in 261 journals. In the past three years, 518 articles were published, accounting for 80.3%. China has the most publications, followed by the United States. Frontiers in Oncology had the highest number of papers (n=26), while Cell had the highest number of citations (n=1206). The current research mainly focuses on two aspects: one is the study of the mechanism of ferroptosis to explore new therapeutic targets, and the other is the exploration of therapeutic methods, such as photodynamic therapy and nanomaterials, in order to inhibit the proliferation of tumor cells, reduce drug resistance, and enhance the efficacy by regulating ferroptosis, which may become a future development trend.
    Conclusion: In recent years, there have been increasing studies on the association between ferroptosis and hepatocellular carcinoma. This is the first comprehensive bibliometric study, which provides a reliable reference for future research in this field and promotes its further development.
    Keywords:  CiteSpace; VOSviewer; bibliometric analysis; ferroptosis; hepatocellular carcinoma; visualization analysis; visualized
    DOI:  https://doi.org/10.3389/fimmu.2025.1549600
  6. Aesthetic Plast Surg. 2025 May 19.
    The Research Trend of Non-surgical Rhinoplasty: A Bibliometric and Visualized Analysis.
    Zhifeng Liao, Yin Wu, Liyao Cong, Shengkang Luo.
       BACKGROUND: Rhinoplasty is one of the most common aesthetic surgeries, with non-surgical rhinoplasty (NSR) gaining popularity due to its affordability and minimal risks. The aim of this study is to use bibliometric analysis to identify prominent research areas and emerging trends within this field.
    METHODS: Research articles on NSR were gathered from the Web of Science Core Collection database. Following this, the analysis of co-authorships, keyword co-occurrences, and citation patterns involving countries, institutions, authors, and key journals was conducted using bibliometric tools VOSviewer and CiteSpace.
    RESULTS: In total, 197 documents related to research on NSR from the years 1900 to 2024 were retrieved. The USA led globally with 61 publications, with the University Of Verona contributing the highest number of articles (11). The journal Aesthetic Plastic Surgery was the most prominent in this specialty, having published 28 articles and Plastic and Reconstructive Surgery receiving the most frequent citations and co-citations. Bertossi D was the most productive author and the most co-cited author. The keywords most commonly associated with these studies, ranked by frequency, included "rhinoplasty," "hyaluronic acid" and "nose." Moreover, the issues related to complications from filler injections and the strategies for their prevention have attracted considerable interest.
    CONCLUSION: This study provides a detailed overview of the primary trends in NSR research. Additionally, it highlights the critical need to enhance efforts to minimize complications associated with filler injections.
    LEVEL OF EVIDENCE V: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
    Keywords:  Bibliometric; Complication; Filler injection; Non-surgical rhinoplasty; Rhinoplasty
    DOI:  https://doi.org/10.1007/s00266-025-04914-9
  7. Open Med (Wars). 2025 ;20(1): 20251202
    Trends in research on preterm birth in twin pregnancy based on bibliometrics.
    Biaobiao Wang, Weishe Zhang, Xiuqing Lv, Qi Li, Jingrui Huang.
       Background: Twin pregnancies are associated with a higher risk of perinatal mortality compared to singleton pregnancies. This study evaluated the developmental trends and summarized the key features of research on preterm births in twin pregnancies.
    Methods: A bibliometric analysis was conducted using publications on preterm births in twin pregnancies from 2014 to 2023, retrieved from the Web of Science Core Collection database. Network and visual analyses were performed using VOSviewer and CiteSpace software. In total, 1,378 articles were included.
    Results: The number of publications in this field has shown a steady increase over the past decade. The United States, China, and England collectively contributed more than half of all publications. King's College London, Columbia University, and Jefferson University were identified as the most influential institutions, fostering extensive collaboration and academic exchange. Am J Obstet Gynecol emerged as the most cited journal. Research has predominantly focused on clinical practices, including prevention strategies, risk factor identification, and perinatal outcomes.
    Conclusion: This bibliometric analysis offers a comprehensive overview of research trends on preterm births in twin pregnancies, highlighting major contributors, influential institutions, and primary research foci. The findings provide valuable insights for researchers, aiding the identification of future research directions in this critical field.
    Keywords:  bibliometric analysis; preterm birth; twin pregnancy
    DOI:  https://doi.org/10.1515/med-2025-1202
  8. J Robot Surg. 2025 May 20. 19(1): 223
    Global trends and hotspots in the learning curves of robotic-assisted surgery: a bibliometric and visualization analysis.
    Xianfa Zhang, Jing Wang, Li'na Chen, Huarong Ding.
      In recent years, there has been a substantial increase in the number of research papers published in the field of robotic-assisted surgery (RAS). Nevertheless, systematic analyses focusing on the key hotspots associated with the learning curves (LCs) of RAS, global collaboration models, and future trends remain relatively limited. This study employed bibliometric methods to conduct a comprehensive search and analysis of papers on the LC of RAS published in the Web of Science Core Collection between 2005 and 2025. A visual analysis was performed across multiple dimensions, including countries, institutions, sources, and authors. The results revealed an upward trend in the number of publications, with a peak observed in 2024. The United States ranked first in terms of publication volume, while Yonsei University emerged as the most productive institution. Mottrie Alexandre contributed to the highest number of publications, and Dindo d received the highest number of citations. Frequently occurring keywords included "outcome", "experience", "minimally invasive surgery", "revision", and "laparoscopic surgery". Clustering keywords were associated with "rectal cancer", "en-y gastric bypass", "transoral robotic surgery", "spine surgery", and "endometrial cancer". Furthermore, the top five keywords with the strongest citation bursts were "laparoscopic radical prostatectomy", "total mesorectal excision", "da vinci", "prostatectomy", and "mrc clasicc trial". This study offers valuable insights into the future development of this field and supports further exploration and innovation.
    Keywords:  Bibliometric analysis; Learning curve; Robotic-assisted surgery; Visual analysis
    DOI:  https://doi.org/10.1007/s11701-025-02391-5
  9. Neurosurg Rev. 2025 May 21. 48(1): 429
    Global research trends of peripheral nerve surgery: a bibliometric and visualized analysis.
    Wencai Wang, Menghao Liu, Zun Wang, Zijie Xiong, Wei Ye, Xianfeng Li, Haicheng Yang.
      Peripheral nerve surgery is an emerging research field gaining attention from neurosurgeons. However, a bibliometric analysis has yet to be conducted in this area. This study aims to visualize the hot spots and trends in publications of peripheral nerve surgery through bibliometric analysis, offering insights into potential future research directions. We analyzed all English-language publications (articles and reviews) on peripheral nerve surgery available in the Web of Science Core Collection from 1967 to 2024. The bibliometrix package, VOSviewer, and CiteSpace were used for visual network analyses of key indicators, including institutions, countries/regions, journals, authors, keywords, and references. Additionally, country maps were created by Scimago Graphica. A total of 605 papers were incorporated in the analysis. The number of publications and citations related to peripheral nerve surgery has increased annually. These publications originated from 947 institutions across 62 countries/regions, with the United States leading. The Mayo Clinic emerged as the most influential institution, while Anesthesia and Analgesia was identified as the journal with the highest number of publications in this area. We identified 2,963 authors, with Ilfeld. brian m. being the most prolific and frequently cited. Keyword cluster analysis revealed four clusters, indicating that surgery and treatment methods, injuries and complications, pain management, and nerve regeneration and repair will be key research hotspots moving forward. Peripheral nerve surgery is a rapidly growing field. Future research is expected to focus on topics related to surgery, injury, and pain management and recovery. Clinical trial number Not applicable.
    Keywords:  Bibliometric analysis; Citespace; Peripheral nerve surgery; VOSviewer
    DOI:  https://doi.org/10.1007/s10143-025-03583-1
  10. Chin Med Sci J. 2025 May 19. 1-13
    Global Research of Medical Technology Management: A Bibliometric Analysis.
    Liu-Fang Wang, Yu-Ni Huang, Richard Sze-Wei Wang, Xiao-Ping Qin, Zhi-Yuan Hu, Bing-Long Wang, Zhi-Min Hu.
       OBJECTIVES: To explore potential keywords, research clusters, collaborative pattern, and research trends in the field of medical technology management (MTM) through bibliometric analysis, providing insights for researchers, policy makers, and hospital administrators.
    METHODS: A retrieval formula was applied to the title, abstract, and keywords in the Web of Science (WoS) Core Collection, along with system-recommended terms, to identify articles on MTM. A total of 181 articles published between 1974 and 2022 were retained for quantitative analysis. The global trend of research output; total citations, average citations, and H-index; and bibliographic coupling, co-authorship, and keyword co-occurrence were analyzed using VOSviewer.
    RESULTS: The number of articles on MTM has been steadily increasing year by year. The focus of research has shifted from addressing basic medical needs to prioritizing emergency response and medical information security. The United States, Italy, and the United Kingdom emerged as the main contributors, with the United States leading in both volume of publications (60 articles) and academic impact (H-index = 21). Authors from the United Kingdom and the United States led the way in cross-border cooperation. The top five institutions, ranked by total link strength among cross-institutional authors, were primarily located in Canada and Spain.
    CONCLUSIONS: The field of MTM has experienced stable growth over the past three decades (1993-2022). The shift of research focus has prompted a heightened emphasis on protecting patient privacy and ensuring the security of medical data. Future research should emphasize interdisciplinary and professional collaboration, as well as international cooperation and open sharing of knowledge.
    Keywords:  bibliometric analysis; global research; medical technology management; research trend
    DOI:  https://doi.org/10.24920/004456
  11. Brain Behav. 2025 May;15(5): e70451
    Evolution Trend of Brain Science Research: An Integrated Bibliometric and Mapping Approach.
    Sujuan Zhang, Jingyan Gu, Yang Yang, Jiangan Li, Lulu Ni.
       BACKGROUND: Brain science research is considered the crown jewel of 21st-century scientific research; the United States, the United Kingdom, and Japan have elevated brain science research to a national strategic level. This study employs bibliometric analysis and knowledge graph visualization to map global trends, research hotspots, and collaborative networks in brain science, providing insights into the field's evolving landscape and future directions.
    METHODS: We analyzed 13,590 articles (1990-2023) from the Web of Science Core Collection using CiteSpace and VOSviewer. Metrics included publication volume, co-authorship networks, citation patterns, keyword co-occurrence, and burst detection. Analytical tools such as VOSviewer, CiteSpace, and online bibliometric platforms were employed to facilitate this investigation.
    RESULTS: The United States, China, and Germany dominated research output, with China's publications rising from sixth to second globally post-2016, driven by national initiatives like the China Brain Project. However, China exhibited limited international collaboration compared to the United States and European Union. Key journals included Human Brain Mapping and Journal of Neural Engineering, while emergent themes centered on "task analysis," "deep learning," and "brain-computer interfaces" (BCIs). Research clusters revealed three focal areas: (1) Brain Exploration (e.g., fMRI, diffusion tensor imaging), (2) Brain Protection (e.g., stroke rehabilitation, amyotrophic lateral sclerosis therapies), and (3) Brain Creation (e.g., neuromorphic computing, BCIs integrated with AR/VR). Despite China's high output, its influence lagged in highly cited scholars, reflecting a "quantity-over-quality" challenge.
    CONCLUSION: Brain science research is in a golden period of development. This bibliometric analysis offers the first comprehensive review, encapsulating research trends and progress in brain science. It reveals current research frontiers and crucial directions, offering a strategic roadmap for researchers and policymakers to navigate countries when planning research layouts.
    Keywords:  bibliometrics; brain science; research hotspot
    DOI:  https://doi.org/10.1002/brb3.70451
  12. Drug Des Devel Ther. 2025 ;19 3949-3970
    Research Trends on Nanomaterials and Hepatocellular Carcinoma From 1999 to 2024: A Bibliometric Analysis.
    Mao-Sheng Liu, Si-Si Zhong, Jin-Ke Wang, Ting Wang, Kun-He Zhang.
       Objective: Extensive exploratory studies have been conducted and promising progress has been made in the use of nanomaterials for the diagnosis and treatment of hepatocellular carcinoma (HCC). Here, we aimed to reveal the evolution and trends in this field through bibliometric analysis.
    Methods: English-language publications (1999-2024) in the field of nanomaterials and HCC were retrieved from the Web of Science database, and eligible articles were selected for bibliometric analysis (data extraction, statistical analysis, and visualization) using VOSviewer and Citespace software.
    Results: A total of 1617 eligible publications were analyzed. The number of publications increased rapidly from 2012 and peaked in 2020. China contributed the most publications, and the United States had the most citations. The Chinese Academy of Sciences was the most influential institution. The "International Journal of Nanomedicine (DOVE Medical)" published the most articles, while "Biomaterials (Elsevier)" was the most influential journal. Jie Tian had the highest number of publications, and Dan Shao had the highest average citation per article. Keyword analysis revealed that nanoparticles for targeted drug delivery, therapy and imaging of HCC were research hotspots. Keywords with citation bursts in the last three years included photodynamic therapy, sorafenib, and tumor microenvironment. Nano-vaccines, nano-antibodies, and synergistic therapies were emerging therapeutic strategies. A total of seven clinical trials were published, but to date there have been no major breakthroughs in HCC therapy using nanomaterials.
    Conclusion: Research on nanomaterials and HCC has shown an overall upward trend, with research hotspots and frontiers focusing on nanoparticle-targeted chemotherapies, photodynamic therapy, and related tumor microenvironment research.
    Keywords:  bibliometric analysis; hepatocellular carcinoma; nanomaterials; research hotspots; research trends
    DOI:  https://doi.org/10.2147/DDDT.S516647
  13. Front Surg. 2025 ;12 1564923
    Research hotspots and trends of sarcopenia in orthopaedic surgery: a bibliometric analysis from 2003 to 2023.
    Ruijiang Li, Yufeng Ge, Yixiao Chen, Gang Liu, Feng Gao, Chao Tu, Ting Li, Ling Wang, Minghui Yang, Xinbao Wu.
       Purpose: This study aimed to evaluate the current bibliometric characteristics, progress, and hotspots of cross-sectional research on orthopaedic surgery and sarcopenia over the past two decades.
    Methods: Publications related to sarcopenia and orthopaedic surgery, published between January 2003 and December 2023, were screened the Web of Science Core Collection. The bibliometric analysis and data visualization processes-including assessments of authors, countries, institutions, keywords, and references-were conducted with Microsoft Office Excel, VOSviewer, CiteSpace, and the Bibliometrix (R package).
    Results: A total of 1,815 documents authored by 8,592 researchers from 2,376 organizations across 77 countries and published in 285 journals were identified. The United States led in both publication volume and total citations. The University of Melbourne had the highest number of publications, while Osteoporosis International emerged as the core journal in this field, with the highest number of publications, citations, and H-index. Cawthon PM was the most influential author, with 21 publications and 3,271 citations. Keywords were categorized into four clusters: Cluster 1 (epidemiology and pathophysiology of sarcopenia), Cluster 2 (clinical outcomes), Cluster 3 (management), and Cluster 4 (physical function). The most common keywords were mainly about "sarcopenia", "body composition", "muscle strength", "hip fracture" and "mortality".
    Conclusions: The bibliometric results indicated a steady and rapid increase in the field of sarcopenia and orthopaedic surgery from 2003-2023. Previous research has predominantly focused on the epidemiology, pathophysiology, clinical outcomes, physical function, and management of sarcopenia. Future research in the intersection of sarcopenia and orthopaedic surgery is likely to delve into the molecular mechanisms of muscle-bone crosstalk, and multidisciplinary management of elderly sarcopenic patients in the orthopaedic field.
    Keywords:  CiteSpace; VOSviewer; bibliometric analysis; osteoporosis; sarcopenia
    DOI:  https://doi.org/10.3389/fsurg.2025.1564923
  14. Curr Neuropharmacol. 2025 May 19.
    The Status and Future Directions of Treatments for Polyglutamine Spinocerebellar Ataxia: A Bibliometric and Visual Analysis.
    Siyu Ding, Linliu Peng, Zhao Chen, Mengyuan Dong, Cuiling Tang, Yiqing Gong, Lang He, Qi Wu, Rong Qiu, Hong Jiang.
       BACKGROUND: Polyglutamine (polyQ) spinocerebellar ataxias (SCA) are a group of autosomal dominant neurodegenerative disorders for which no effective treatments currently exist. These conditions impose a significant burden on patients, their families, and society. Consequently, the treatment of these disorders has attracted significant global interest.
    OBJECTIVE: We conducted this bibliometric analysis to identify the key research hotspots and predict the future research directions of this field.
    METHODS: Studies relating to the treatment of polyQ SCA published from 1999 to 2024 were retrieved from the Web of Science Core Collection database. Relevant papers were selected using predefined inclusion and exclusion criteria. HistCite, VOSviewer, CiteSpace, and alluvial generator were used in the bibliometric analysis.
    RESULTS: Overall, 935 papers were included. The number of publications in this field showed a trend toward a fluctuating increase. The United States and the University of Coimbra were the leading countries and institutions, respectively, in terms of publication number. The two most productive and highly cited authors were Luis Pereira de Almeida and Patricia Maciel. The journals Cerebellum, Human Molecular Genetics, and Movement Disorders were considered the most influential based on the number of publications and citations. Furthermore, "new SCA types", "Huntington's disease", "clinical trial", "gene therapy", "disease models," and "Aggregation clearance therapy" emerged as current hotspots in this field, as revealed by the reference and keyword analyses.
    CONCLUSION: This study presents a systematic bibliometric analysis of research on the polyQ SCA treatment, which we hope will assist researchers in identifying the key topics and future research directions in this field.
    Keywords:  Bibliometrics; CiteSpace; VOSviewer; gene therapy.; polyglutamate spinocerebellar ataxia; treatment
    DOI:  https://doi.org/10.2174/011570159X360111250502055242
  15. Acta Psychol (Amst). 2025 May 20. pii: S0001-6918(25)00380-4. [Epub ahead of print]257 105067
    Research development of teachers' emotional intelligence in the 21st century: A bibliometric analysis.
    Dong Wang, Jing Qin.
      Emotional intelligence (EI) has been recognized as a critical factor in shaping teachers' teaching effectiveness, classroom management, professional well-being, and mental health. As a key psychological construct in the teaching profession, teacher emotional intelligence (TEI) has received increasing scholarly attention in recent years. This study employs bibliometric analysis to quantitatively and visually analyze 258 academic publications on TEI from the WOS core databases in the 21st century. The study reports some bibliometric characteristics of these publications, in which it found that the number of annual publications over the years went through two distinct phases: a nascent and early exploratory period (2000-2018) and a rapid growth period (2019-2023). Spain and China emerged as leading contributors, while Canada's studies demonstrated the highest citation impact (average citations per article). The study also shows other valuable information such as the primary sources of publications, the most prolific authors and institutions, and the most cited publications, etc. Moreover, the relationships among items of publications and keywords were identified and analyzed to present the research status of this field. "Burnout", "job satisfaction" and "self-efficacy" are the high-frequency and core keywords. It can be found that research on TEI has constantly evolved into more diverse themes in the 21st century, with "EI", "higher education" and "engagement" being consistent themes across different development periods. Notably, topics like "support", "mindfulness" and "intention" are emerging, expected to continue gaining intention. Based on data analysis and literature reading, this article provides several possible directions for future research in TEI.
    Keywords:  Bibliometric analysis; Biblioshiny; Emotional intelligence; Research development; Teacher emotion; VOSviewer
    DOI:  https://doi.org/10.1016/j.actpsy.2025.105067
  16. Front Med (Lausanne). 2025 ;12 1530278
    Global research trends and hotspots in erysipelas: a bibliometric analysis from 2000 to 2024.
    Chaoxi Zhou, Guangrong Yu, Qinglei Wang.
       Background: Erysipelas, an acute bacterial infection affecting the dermis and lymphatic system, poses significant clinical challenges due to recurrence, antibiotic resistance, and diagnostic overlap with other skin infections. Despite growing research in this area, a comprehensive bibliometric analysis is lacking, leaving gaps in understanding the publication trends, key research hotspots, and collaborative networks that shape the field.
    Methods: This study conducted a bibliometric analysis of erysipelas research from 2000 to 2024 using the Science Citation Index Expanded (SCI-EXPANDED) within the Web of Science Core Collection. English-language articles and reviews were selected, and data were analyzed using VOSviewer, Bibliometrix, and CiteSpace to visualize publication volume, co-authorship networks, geographic distribution, keyword trends, and collaborations.
    Results: The results indicate a steady growth in erysipelas research from 2000 to 2024, with annual publication volumes increasing from 9 articles in 2000 to 30 articles in 2022, reflecting a significant rise in interest within the field. The United States leads in contributions with 69 publications and 2,739 citations, institutional analysis highlights Radboud University, Karolinska Institute, and others as key contributors in collaboration and citation impact. Keyword co-occurrence analysis identifies major research hotspots, including familial Mediterranean fever, lymphedema therapy, and the management of complex skin infections, with emerging themes like "liposuction" and "skin and soft tissue infections" gaining attention in recent years.
    Conclusion: This study highlights the growing advancements in erysipelas research, including insights into risk factors, diagnostics, and therapies, while emphasizing the need for continued collaboration and innovation to address challenges like antibiotic resistance, recurrence, and accurate differentiation from similar conditions.
    Keywords:  antibiotic resistance; bibliometric analysis; diagnosis and differential diagnosis; erysipelas; risk factors
    DOI:  https://doi.org/10.3389/fmed.2025.1530278
  17. Front Med (Lausanne). 2025 ;12 1523630
    Publications of systematic review and meta-analysis in the indexed anesthesia journals: a 10-year bibliometric analysis.
    Zhi-Yao Zou, Xiao-Jing Huang, Jin-Rui Song, Yun-Tai Yao.
       Background: Anesthesiology research is growing at a rapid pace. It is essential to understand the scope and trends over time to identify gaps and future areas for growth. Systematic reviews and meta-analyses (SRMA) are summaries of the best available evidence to address a specific research question via a comprehensive literature search, in-depth analyses, and synthesis of results. High-quality SRMA are increasingly used and play an essential role in medical research.
    Objective: We aimed to explore the trends of SRMA in indexed anesthesia journals.
    Methods: SRMA published in indexed anesthesia journals from 2013 to 2023 were retrieved from the Web of Science database. Data were presented via descriptive statistics. We used CiteSpace 6.1.R6 to analyze countries, institutions, journals, authors, and keywords through visual maps to explore the research hotspots and trends. The journal's Journal Citation Reports partition, impact factor, annual publications, journals H-index, and a number of highly-cited papers were calculated in the WoS database.
    Results: A total of 34 indexed anesthesia journals and 3,004 SRMA were included. The year 2021 was the year with the most SRMA (385/3,004). Out of the 3,004 SRMAs, 36 (0.03%) were highly cited papers, and 22 of the 36 highly cited papers focused on "pain management." BRITISH JOURNAL OF ANAESTHESIA had the highest 5-year impact factor (9.6) in 2022 Journal Citation Reports, the most significant number of publications (268/3,004), the highest total number of citations (13,173/86,145), and the most significant number of SRMAs cited more than 100 (36/160). ANAESTHESIA achieved the highest impact factor in the 2022 Journal Citation Reports (10.7) and the highest average annual citations (58.82). PAIN had the highest number of highly cited papers (15/36). The United States of America was the most productive country, with 823/3,004 SRMAs. University Toronto had the highest number of publications (245/3,004). The most frequent of keywords was the topic "Pain Management" (1,622/29.1%).
    Conclusion: This present study would be valuable to practitioners, academics, researchers, and students in understanding the dynamics of progress in anesthesiology.
    Keywords:  anesthesia journal; bibliometrics; citation; meta-analysis; systematic review
    DOI:  https://doi.org/10.3389/fmed.2025.1523630
  18. Front Sports Act Living. 2025 ;7 1545264
    Research trends in the field of sport impact on the economy: a bibliometric analysis.
    Marina Kudinska, Irina Solovjova, Žanete Korde.
      In this paper, the authors summarize the results of the bibliometric analysis. The object of the analysis is scientific publications published in the Scopus database in the scientific field of the impact of sports on the economy. The study aims to fill the research gap in the bibliometric analysis of the impact of sports on the economy by providing an empirical contribution that reveals trends in the scientific literature on the impact of sports on the economy, the most productive researchers, institutions, countries, journals in this field of research, and identifying a bibliometric framework that includes networks between researchers. Scientific articles indexed in Scopus were analyzed with no specific time limits using bibliometric analysis methods-performance analysis, citation analysis, and science mapping. We employed performance analysis, citation analysis, and science mapping via the Bibliometrix package R Studio® and the VOSviewer. The results of the systematic review show that, according to the Scopus database, 801 authors have studied the impact of sports on the global economy, and 299 scientific articles have been published in various journals around the world during the study period. This relatively low number suggests insufficient attention on the part of researchers to the importance of the sports sector. The most active researchers are from the USA, the UK, and China. The most influential journals and research institutions have been identified. The study results showed disagreement between the authors in some areas of the study (economic impact of major sporting events, impact of new sports infrastructure on regional economic growth, illustrating the ongoing debates in the field.
    Keywords:  analysis; bibliometric; impact; publications; scopus; sports
    DOI:  https://doi.org/10.3389/fspor.2025.1545264
  19. Front Neurol. 2025 ;16 1565749
    Therapeutic hypothermia for neonates: a bibliometric analysis and visualization research.
    Tingting Zhou, Peishan Liang, Na Dai, Mingxin Ma, Jiangang Lin, Jie Zhu, Guangli Ren.
       Background: Therapeutic hypothermia is an important treatment for cerebral protection and has a positive effect on neonatal encephalopathy. This study aims to analyze the research hotspots and frontiers of therapeutic hypothermia for neonates through bibliometric analysis and visualization research.
    Methods: The articles and reviews on therapeutic hypothermia for neonates were identified from the Web of Science Core Collection (WOSCC) database on October 18, 2024. CiteSpace and VOSviewer were used to analyze the countries/regions, institutions, authors, journals, references, and author keywords.
    Results: A total of 1,199 articles were retrieved from 378 institutions in 75 countries/regions. The annual number of publications and citations showed an upward trend in this field. Massaro, An N. N., and Shankaran. S. were the key authors who had most publications and citations. Pediatric Research was the most popular journal in the field, Pediatrics was the most influential. All the author keywords were divided into 12 clusters, and "hypoxia-ischemia encephalopathy," "therapeutic hypothermia" and "perinatal asphyxia" were high-frequency keywords in this field. Keyword burst shows that "childhood outcome," "neonatal seizure," "preterm," and "risk factors" were important aspects of research in recent years.
    Conclusion: The present study is the first to apply bibliometric analysis to explore therapeutic hypothermia for neonates, aiming to identify research hotspots and frontiers in this field. In recent years, research on therapeutic hypothermia for neonates has rapidly increased, with therapeutic hypothermia for perinatal asphyxia neonates being a research hotspot. To improve the neurological prognosis of neonates, more researches focused on how to expand the benefits of the neonatal population and enhance neuroprotective effects. It may provide future research directions for neonatal experts.
    Keywords:  CiteSpace; VOSviewer; bibliometric; neonates; therapeutic hypothermia
    DOI:  https://doi.org/10.3389/fneur.2025.1565749
  20. Neurol India. 2025 May 01. 73(3): 506-512
    Bibliometrics and Visualization Analysis of Neuromuscular Junction Model.
    Xincheng Du, Wenwen Liu, Jin Geng, Haowen Qiao, Yu Zhou.
       OBJECTIVE: Neuromuscular junctions, which are responsible for voluntary motor function, are the chemical synapses between motor neurons and skeletal muscle fibers. In this study, we performed a scientometric analysis that can be used to construct and visualize networks of neuromuscular junction model (NMJM) using bibliometric methods.
    MATERIALS AND METHODS: A literature survey for NMJM was conducted using "TS= (neuromuscular junction model)," including literature titles, abstracts, and keywords, under the Web of Science Core Collection (WoSCC). Document production was analyzed by document citation, source journals, authors, highly cited documents, countries, organizations, impact factors.
    RESULTS: A total of 2046 articles published over the past two decades were retrieved and analyzed. Our results showed that the number of publications in NMJM has increased rapidly over the past 20 years. The most productive author in terms of total publications about NMJM was Thomas H. Gillingwater with 27 documents, who worked at the University of Miami. The geographic distribution of publications showed that majority of them were from the USA. In addition, the research hotspot of NMJM was expanding from the establishment of NMJM to mechanistic studies of diseases.
    CONCLUSIONS: This study provides a unique perspective for understanding the evaluative history and future trends of NMJM.
    Keywords:  Bibliometric analysis; VOSviewer; neuromuscular junction model
    DOI:  https://doi.org/10.4103/ni.ni_385_22
  21. Naunyn Schmiedebergs Arch Pharmacol. 2025 May 19.
    Authorship analysis of publications in Naunyn-Schmiedeberg's Archives of Pharmacology (1969-2024).
    Siddig Ibrahim Abdelwahab, Abdullah Farasani, Jobran M Moshi, Saeed Alshahrani, Waseem Hassan.
      Naunyn-Schmiedeberg's Archives of Pharmacology (NSAP) is the world's oldest journal in the field of pharmacology. Approximately fourteen bibliometric studies published by NSAP have examined its scholarly trajectory and role in pharmacology. However, no study has yet thoroughly analyzed author contributions throughout the journal's recent history. This study addresses the gap by analyzing all publications in NSAP from 1969-onward using data retrieved from the Scopus database. The dataset included bibliographic information such as titles, author names, affiliations, years of publication, and document types. During this period, NSAP published 13,422 documents-comprising 12,687 original articles and 735 reviews-with an annual publication growth rate of 2.74% and an average document age of 31.2 years. These publications received 252,490 citations, yielding an average of 18.81 citations per document. The top three most productive authors (based on number of publications) were Starke, K. (143 publications), Göthert, M. (106), and Seifert, R. (101). This ranking was consistent across three independent tools-VOSviewer, R Studio, and Scopus-reinforcing the accuracy of manual verification. A total of 14 authors were identified with at least 50 publications each. For this select group, detailed performance indicators were calculated. These indicators allowed for a multi-dimensional evaluation of author performance beyond simple publication counts. Precisely, we provided number of publications, total citations, citations per publication, h-index, g-index, m-index, HG composite index, Q2 index, and year of first publication for the 50 authors. In fact, the publication data for 23,476 authors are presented in supplementary Table 1 along with the stated indicators. This study highlights the extent of author involvement with NSAP and emphasizes the importance of using various tools and measures to gain a fuller understanding of academic productivity.
    Keywords:  All authors; NSAP; Performance indicators; Total publications
    DOI:  https://doi.org/10.1007/s00210-025-04253-1
  22. Discov Oncol. 2025 May 19. 16(1): 820
    Current trends and landscape of drug resistance in renal cell carcinoma: a bibliometric analysis.
    Kenan Zhang, Shixu Chen, Zhenzhen Zhou, Shuanbao Yu, Yonghao Zhan, Xuepei Zhang.
       INTRODUCTION: Renal cell carcinoma (RCC) is a common type of kidney cancer, and the prognosis for patients with advanced-stage disease remains poor. One major obstacle is the development of drug resistance, which severely limits the effectiveness of therapeutic interventions. This bibliometric study aims to provide a comprehensive overview of current research trends on drug resistance in RCC.
    METHODS: This study examines publications on drug resistance in RCC from 2000 to 2023, sourced from the Web of Science Core Collection (WoSCC). Detailed analyses were conducted to identify research hotspots, academic collaborations, and emerging trends. CiteSpace, SCImago Graphica, and VOSviewer were utilized to conduct these analyses comprehensively.
    RESULTS: This study analyzed a total of 2,804 publications from the WoSCC database. The number of annual publications showed a consistent upward trend, with an average annual growth rate of 8.12%. The United States had the highest number of publications, followed by China and Japan. The most productive institutions were the University of Texas System, Harvard University, and the National Institutes of Health (NIH). Alfred H. Schinkel emerged as the most prolific author, also having the highest H-index. The three most frequent research categories were oncology, pharmacology and pharmacy, and biochemistry and molecular biology. The evolution of research topics was assessed in 5-year intervals, revealing that recent themes such as ferroptosis and immunotherapy have gained increasing attention. Keyword analysis indicated a shift in research focus toward cell lipid metabolism, androgen receptor and specific molecular signatures.
    CONCLUSION: This study offers the first comprehensive bibliometric analysis specifically focused on drug resistance in RCC. It identifies current research trends, highlights emerging hotspots, and provides insights into key contributors and ongoing challenges in the field. Our study provides a theoretical reference and guidance to guide future research efforts to address drug resistance in RCC more effectively.
    Keywords:  Bibliometric analysis; Drug resistance; Immunotherapy; Renal cell carcinoma; Targeted therapy; Visualization
    DOI:  https://doi.org/10.1007/s12672-025-02594-0
  23. Cureus. 2025 Apr;17(4): e82636
    A Bibliometric Analysis of the 100 Most-Cited Articles on Soccer Injuries.
    Amr Chaabeni, Meryam M Slama, Amine Kalai, Helmi Ben Saad, Alejandro López-Valenciano, Zohra Ben Salah Frih, Anis Jellad.
      Bibliometric analysis is increasingly utilized to assess specific research fields and identify emerging areas of interest. While it is commonly employed in sports medicine research to assess injuries, few studies have concentrated on soccer. The aim of this study was to identify the top 100 most-cited publications related to soccer injuries and conduct a comprehensive bibliometric mapping analysis to understand research trends. The bibliographic search was performed on November 16, 2022, using the Clarivate Analytics Web of Science Database, and the 100 most-cited articles related to soccer injuries were identified and reviewed. TheBibliometrix R-package software ( https://www.bibliometrix.org/) was used for data analysis. The 100 most-cited articles were published between 1990 and 2017. The majority of articles were published in the British Journal of Sports Medicine (32 articles) and the American Journal of Sports Medicine (31 articles). Most corresponding authors (26%) originated from Sweden. Approximately half of the articles were observational studies using level 2 evidence. The primary research topics included epidemiology (25 articles) and prevention (24 articles). Most articles focused on male (53%), adult (57%), and elite soccer players (51%), while the majority of articles about female players (76.9%) ranked in the top 50 cited articles. This study underscores the necessity for more comprehensive research on soccer injuries, with a particular focus on female players, to bridge existing knowledge gaps and enhance injury prevention strategies.
    Keywords:  bibliometric research; football injury; injury epidemiology; prevention; soccer; trend analysis
    DOI:  https://doi.org/10.7759/cureus.82636
  24. Geriatr Nurs. 2025 May 22. pii: S0197-4572(25)00204-6. [Epub ahead of print]64 103375
    Research progress and hotspots of the impact of Mediterranean diet on aging from 2004 to 2023: A bibliometric analysis.
    Jian Xu, Hao Zou, Chuanliang Shu, Yanying Liu, Yanlei Yin, Beibei Ni.
       OBJECTIVE: This study aims to identify research hotspots and trends by conducting a bibliometric report regarding the impact of MD on aging.
    METHODS: Publications on MD and aging were extracted from the Web of Science Core Collection. R software, VOSviewer and CiteSpace were employed to detect research hotspots and frontiers.
    RESULTS: The number of annual articles has grown rapidly. The core research content in this field are the mechanism of the antiaging action of MD (inflammation, oxidative stress and gut microbiome) and age-related diseases (particularly cardiovascular diseases, Alzheimer's disease and metabolic syndrome). The interplay between MD and the gut microbiome or physical activity impacting healthy aging has been the recent hotspot and research frontier.
    CONCLUSION: This study quantitatively and objectively described the research status and research focus of the impact of MD on aging, which provides reference for future research in this field.
    Keywords:  Aging; Bibliometric analysis; Hotspots; Mediterranean diet; Trends
    DOI:  https://doi.org/10.1016/j.gerinurse.2025.05.014
  25. Aesthetic Plast Surg. 2025 May 23.
    A Comprehensive Bibliometric Study on Silicone Implants: From Aesthetics to Prosthetics and Augmentation.
    Sa'ed H Zyoud.
      Silicone implants have significantly advanced, evolving from aesthetic enhancements to essential components in reconstructive surgery. This study aims to assess the development of and trends in global silicone implant research from 1948 to 2024 through bibliometric analysis. The analysis was carried out via the Scopus database, with publications classified on the basis of various factors, including the countries/regions of focus, journals, institutes, citations, and content analysis, to identify emerging and hot topics. Furthermore, VOSviewer software (version 1.6.20) was used to perform a bibliometric analysis of trending research topics. A total of 4522 articles were retrieved from the Scopus database between 1948 and 2024. Most of these were research articles (3604, 79.70%), followed by letters (359, 7.94%) and reviews (222, 4.91%). Research on silicone implants has shown a significant upwards trajectory (R2 = 0.7968; p < 0.001) over the years. The United States led the list, with 1435 publications (31.73%), followed by Germany (249 publications, 5.51%) and China (235 publications, 5.2%). Plastic and Reconstructive Surgery was the leading journal, with 421 articles (9.31%), followed by Aesthetic Plastic Surgery with 123 articles (2.72%). Before 2005, silicone implant research focused mainly on breast reconstruction and the impact of implants on breast cancer detection. Recent research trends suggest a shift towards long-term results, revision surgeries for joint implants, psychological and functional outcomes in patients with arthroplasty, and innovations in implant materials, sustainability, and environmental concerns. In conclusion, this bibliometric analysis provides a comprehensive overview of the evolution of scientific knowledge related to silicone implants. Understanding the development of scientific knowledge about silicone implants is essential for the global scientific community, policymakers, and plastic surgeons. This understanding helps improve the effectiveness of future research and offers valuable insights into the role of silicone implants in augmentation, reconstructive surgery, and plastic surgery while also addressing their potential impacts.Level of Evidence V This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
    Keywords:  Aesthetics surgery; Bibliometric; Plastic surgery; Silicone implants
    DOI:  https://doi.org/10.1007/s00266-025-04956-z
  26. Quant Imaging Med Surg. 2025 May 01. 15(5): 4431-4444
    Global trends and developments in pulmonary magnetic resonance imaging research: a bibliometric analysis of the past decade.
    Ting Wu, Linyu Wu, Yufan Chen, Jun Wu, Chen Gao, Maosheng Xu.
       Background: Pulmonary magnetic resonance imaging (MRI) has the advantage of nonionizing radiation and multiparameter imaging of structure and function, facilitating its clinical use in a variety of pulmonary diseases. This study aimed to identify the research trends and emerging topics in pulmonary MRI by conducting a comprehensive bibliometric analysis of the field over the past decade.
    Methods: A search of the Web of Science Core Collection database was conducted with the words "lung" and "MRI" for literature published from 2014 to 2023. The data were further analyzed with R and CiteSpace software in terms of annual publications and citations, collaborative networks (countries, institutions, and authors), source's local impact, keyword clustering, and burst analysis.
    Results: A total of 1,839 publications related to pulmonary MRI have been published over the last decade, with a relatively slow growth trend. The top three journals in terms of total publications and citations were Magnetic Resonance in Medicine, Journal of Magnetic Resonance Imaging, and Radiology. The most productive country was the United States, and the countries with the strongest collaborative links were the United States and the United Kingdom. The most productive institutions and authors were Ruprecht Karls University Heidelberg (articles, n=309) and Wild JM (articles, n=86), respectively. Keyword cluster analysis identified five clusters: "lung cancer", "magnetic resonance imaging", "lung MRI", "cystic fibrosis", and "congenital diaphragmatic hernia". Keyword burst analysis showed that the keywords with the highest burst intensity in the first 5 years and the last 5 years were "mice" and "standardization", respectively.
    Conclusions: Over the past decade, research trends in pulmonary MRI have focused on lung cancer and cystic fibrosis as the dominant clinical diseases. Research has been centered on standardizing pulmonary MRI to promote its clinical application.
    Keywords:  Pulmonary; bibliometrics; lung diseases; magnetic resonance imaging (MRI)
    DOI:  https://doi.org/10.21037/qims-24-2205
  27. CNS Neurol Disord Drug Targets. 2025 May 16.
    Trends in Research on Gantenerumab for Alzheimer's Disease: A Bibliometric and Thematic Analysis.
    Siddig Ibrahim Abdelwahab, Manal Mohamed Elhassan Taha, Hassan Ahmad Ahmad Alfaifi, Amal Hamdan Alzahrani, Ieman A Aljahdali, Omar Oraibi, Sohaila Ali, Bassem Oraibi, Abdullah Farasani, Ahmed Ali Jerah, Yasir Osman Hassan Babiker, Anas A Ahmed, Gassem Gohal, Osama Albasheer.
       BACKGROUND: Gantenerumab (GR), a promising therapeutic agent for Alzheimer's disease (AD), has been the subject of extensive research. In this study, we aimed to provide a comprehensive analysis of the literature on GR.
    METHODS: A systematic search was conducted using the PubMed, Scopus, and Web of Science databases. VOSviewer and Bibliometrix were utilized to analyze bibliographic data.
    RESULTS: The analysis of the literature on GR revealed distinct publication trends. Reviews accounted for 52% of the records, followed by research articles (31%). The United States contributed the highest proportion of publications (26%). The Journal of Prevention of Alzheimer's Disease was the most prolific source (21 articles). The annual number of publications increased steadily from 2009 to 2024. Major international collaborations were observed among the United States, the United Kingdom, Switzerland, France, and Sweden. Research activity consistently centered on key themes, such as amyloid imaging, biomarkers, clinical trials, and β-amyloid. Thematic mapping identified specialized subfields, core research areas, and dynamic shifts in topics, offering a comprehensive overview of the GR research landscape.
    CONCLUSION: GR-related literature showed sustained thematic focus, growing international collaboration, and a steady rise in publication volume within the field of AD. These findings highlight the continued need for clinical and biomarker-focused investigations to advance therapeutic development in AD.
    Keywords:  Alzheimer's disease; Gantenerumab; amyloid-beta; bibliometric analysis.; clinical trials
    DOI:  https://doi.org/10.2174/0118715273349645250324040257
  28. J Family Med Prim Care. 2025 Apr;14(4): 1155-1160
    Global trends and hotspots in diabetes and obesity research: A bibliometric analysis.
    Xian Wang, Jinhu Chen, Qiuyu Bai.
      Diabetes and obesity are major global public health challenges, with their incidence continuously rising, placing a significant burden on healthcare systems worldwide. To better understand the research trends and hotspots in these two areas, this study conducted a bibliometric analysis of relevant literature published between 2003 and 2023. The study utilized the Web of Science Core Collection database to select original research articles and reviews on diabetes and obesity published from 2003 to 2023. CiteSpace and R software were employed for bibliometric analysis, including co-occurrence analysis of keywords, co-citation analysis, and collaboration network analysis. Research on diabetes and obesity has seen significant growth globally, with the United States, China, and the United Kingdom being the most active countries in this field. The transnational collaboration network is expanding, especially between Europe, the United States, and Asia. Research hotspots include lifestyle interventions, weight management, and nutritional interventions. Future research should focus on international collaboration and interdisciplinary approaches, particularly in clinical practice for primary care physicians. Personalized lifestyle interventions and management strategies for diabetes and obesity represent key areas for further exploration.
    Keywords:  Bibliometric analysis; CiteSpace; diabetes; obesity; research hotspots
    DOI:  https://doi.org/10.4103/jfmpc.jfmpc_1472_24
  29. Front Microbiol. 2025 ;16 1571883
    Bibliometric analysis of the S24-7 family and its association with health.
    Fangmei Gao, Fenfen Wang, Dandan Wang, Guankui Du, Fangfang Gao.
      A burgeoning corpus of evidence indicates that S24-7 is integral to human health, with links to obesity, inflammation, metabolism, and dietary interactions. In the present study, we conducted a comprehensive review of the S24-7 literature from the past 10 years, augmented by an evaluation of research trends using both quantitative and qualitative approaches. From the Web of Science (WoS) database, we retrieved 903 research articles and four review articles pertaining to S24-7, also known as Muribaculaceae, that were published between January 1, 2014, and January 1, 2024. Employing software tools such as R, Biblioshiny, VOSviewer, the Bibliometric Analysis Platform, and Pajek, we performed visual mapping and correlation analyses on the collected documents. Our analysis revealed China and the United States as the leading publishers in the field of S24-7 research. The top three academic journals for S24-7 family research are Food and Function, Frontiers in Microbiology, and Nutrition. Among individual contributors, Zhang Y stands out with 31 publications and an h-index of 13, representing 3.42% of the 907 articles analyzed. Jiangnan University leads in institutional output with 46 publications. Keyword analysis underscores that S24-7 research is concentrated on examining the family's associations with obesity, inflammation, metabolism, and diet. This study highlights notable contributions from various countries, institutions, journals, and researchers, shedding light on the influence of the S24-7 family on human health. It serves to inform future research directions and clinical applications concerning the S24-7 flora.
    Keywords:  S24-7; bibliometric analysis; gut microbiota; health; research hotspots
    DOI:  https://doi.org/10.3389/fmicb.2025.1571883
  30. Front Microbiol. 2025 ;16 1572400
    Bibliometric analysis of hotspots in Staphylococcus aureus drug resistance research.
    Jianguo Shi.
       Objective: Bibliometric analysis was used to visualize the current literature data on Staphylococcus aureus drug resistance.
    Methods: We used a bibliometrix package that utilizes R 4.4.1, all S. aureus drug resistance related research literature in the WOS core database, and data visualization and analysis of the retrieved research literature.
    Results: A total of 3,253 research articles on Staphylococcus aureus resistance were screened, and the number of publications related to Staphylococcus aureus resistance is increasing year by year. China ranks first in the number of publications, and the United States ranks first in terms of citations. Frontiers in microbiology has published the most articles on this research topic. Wang Y, Lee JH, and Simoes M have published the most articles, and Franci G has the most citations. The Egyptian Knowledge Bank (EKB), the Chinese Academy of Sciences, and Harvard University are the main research institutes. A total of 15,824 authors have contributed to the field, with the majority of authors coming from China, followed by South Korea and the United States, and most of them coming from the Chinese Academy of Science and Jilin University. The mechanism of drug resistance in Staphylococcus aureus was the most important research hotspot, with Staphylococcus aureus coming up 984 times, (10%), followed by antibiotic-resistance (693 times, 7%) and biofilm formation (517 times, 5%).
    Conclusion: This study comprehensively summarizes past research trends in Staphylococcus aureus resistance and identifies the countries, institutions, authors, journals, and publications involved in this field. The results provide a comprehensive overview of the study of resistance in Staphylococcus aureus.
    Keywords:  Staphylococcus aureus; analysis; bibliometrics; drug resistance; knowledge map
    DOI:  https://doi.org/10.3389/fmicb.2025.1572400
  31. Medicine (Baltimore). 2025 May 16. 104(20): e42342
    Visualization analysis of ovarian hyperstimulation syndrome based on bibliometrics.
    Cailian Huang, Qian Jiang, Zhuoyan Liang, Yongge Guan.
       OBJECTIVES: This study offers valuable insights into the research hotspots and trends related to ovarian hyperstimulation syndrome (OHSS). By systematically analyzing articles published on the subject up to July 15, 2024, it provides significant perspectives for future research endeavors.
    METHODS: A literature search was executed utilizing the Web of Science core database to retrieve relevant records, with case reports subsequently reassigned to a separate file. During the analysis phase, countries, institutions, authors, journals, references, and keywords underwent thorough examination using tools such as VOSviewer v1.6.10, CiteSpace, R package, and Microsoft Excel 2021.
    RESULTS: From the inception of the database to July 15, 2024, a total of 1125 articles were retrieved, including 255 case reports, with a citation count of 23,768. The top 5 countries with the highest article counts were China, the USA, Ireland, the United Kingdom, and Spain. In terms of institutions, Tel Aviv University, Zhengzhou University, Aristotle University of Thessaloniki, Cairo University, and Free University of Brussels were the leading contributors, with Tel Aviv University having the highest number of published articles. Keywords were systematically classified into 4 clusters within the coverage keyword network: diagnosis and clinical manifestations; risk factors and pathogenesis; prevention and treatment; and prognosis and complications. The case reports primarily focused on patients with clinical manifestations of pleural and abdominal fluid accumulation, venous thrombosis, and, in some cases, fatal outcomes.
    CONCLUSION: The present study conducts a bibliometric analysis of OHSS case reports to understand its prevalence and trends. The study highlights the shift towards advanced assisted reproduction technologies and prophylactic medication as research hotspots, offering valuable guidance for future OHSS research.
    Keywords:  CiteSpace; OHSS; VOSviewer; bibliometric analysis; fertility techniques; preventive treatment strategies
    DOI:  https://doi.org/10.1097/MD.0000000000042342
  32. Cureus. 2025 Apr;17(4): e82452
    Academic Output of Anesthesiology Departments in Canada From 2014 to 2023: A Bibliometric Analysis Study.
    Ekambir Saran, Connor T Brenna, Amrit Brar, Jiwon Lee, Daisy Thomas, Ella Huszti, Shiven Sharma, Karim S Ladha.
      Anesthesia research is essential for advancing clinical practice and patient care. The purpose of this study was to analyze research productivity in Canadian anesthesiology departments from 2014 to 2023, focusing on trends in publication volume, methodology, and the impact of the COVID-19 pandemic. A bibliometric analysis was conducted following a pre-registered protocol to identify articles in the PubMed database, which were published between 2014 and 2023 (inclusive) with corresponding authors from Canadian anesthesiology departments. Data extracted for each article included the year of publication, journal, and study design. Descriptive statistics and Pearson correlation coefficient were used to compare trends, while annual publication rates were assessed with linear regression. An interaction term captured differences between pre-pandemic (2014-2020) and post-pandemic (2021-2023) periods. A total of 3,490 articles met the inclusion criteria. From 2014 to 2020 (pre-pandemic period), publication volume increased significantly by 28.7 studies/year (95% CI: 19.2-38.2, p < 0.001). In contrast, 2021-2023 (post-pandemic period) showed a non-significant decline of 13.0 studies/year (95% CI: -48.6-22.6, p = 0.405). Pre-pandemic trends showed significant growth in reviews, case-control/cohort studies, and surveys, while publication rates declined across most categories after 2020. Our findings illustrate an increase in research productivity among Canadian anesthesiology departments from 2014 to 2020, followed by a plateau in publication volume after the onset of the COVID-19 pandemic. This stagnation highlights a critical area for future exploration, including examining how pandemic-related factors, such as shifts in clinical priorities, resource allocation, and adoption of telemedicine in pre-operative clinics, have influenced research productivity. As the field of anesthesiology adapts to post-pandemic realities, ongoing bibliometric studies will be essential to monitor these trends and guide the trajectory of Canadian anesthesia research amid emerging clinical challenges and evolving academic priorities.
    Keywords:  academic anesthesia; anesthesia research; bibliometric analysis; covid-19; publication trends
    DOI:  https://doi.org/10.7759/cureus.82452
  33. Cureus. 2025 May;17(5): e84197
    Research Trends and Structural Characteristics of Healthcare Research in Japan, Including the First Half of the New Coronavirus Spread Period: A Bibliometric Analysis.
    Yasutoshi Moteki.
      This study aims to conduct a bibliometric analysis to characterize the trends and research features of health administration in Japan, in terms of themes and structural aspects, such as institutional affiliations, up to the early stages of the spread of the new coronavirus. Literature data were obtained from the United States National Institutes of Health (NIH) database, using the search formula (Healthcare[Title/Abstract] AND Japan[Title]), and the dataset was obtained on March 15, 2025. The total number of data points analyzed was 1066. Research trends, such as the characteristics of themes based on KeyWords Plus (Clarivate, Philadelphia, USA) and their changes, and the academic structure focusing on the country of origin, institutional affiliations, and publication journals, were quantitatively analyzed using the bibliometrics tools in the R package (Biblioshiney interface) for literature up to 2021, when the impact of coronavirus disease of 2019 (COVID-19) became pronounced in Japan. The KeyWords Plus analysis revealed a substantial research emphasis on healthcare human resources, and confirmed an increase in COVID-19-related research around 2020, when the impact of the novel coronavirus infection spread in Japan. Notably, the results of the bibliometric analysis highlight the aspect that healthcare human resources was one of the main focuses of the study area. However, limitations of textmining methods were observed in the export function of the CiNii database (National Institute of Informatics, Tokyo, Japan), which comprehensively collects articles written in Japanese. In order to grasp research trends in the field of healthcare in Japan, regardless of language, it is necessary to enhance multilingual support in Japanese academic information databases and develop an international academic information database (such as Web of Science, Scopus, OpenAlex, etc.) to expand the scope of collection.
    Keywords:  academic structure; bibliometrics analysis; japan; research trends; thematic map
    DOI:  https://doi.org/10.7759/cureus.84197
  34. Public Health Nurs. 2025 May 19.
    Bibliometric Analysis of the 40-Year History of Public Health Nursing (1984-2024).
    Ayla Kaya.
       OBJECTIVE: This study was conducted in honor of Public Health Nursing's 40th anniversary. The study was unique as it provided the first bibliometric analysis revealing the evolution of Public Health Nursing's publications.
    DESIGN AND METHODS: This study was a bibliometric analysis. The study was carried out by analyzing 2985 publications. Data were collected from the Web of Science Core Collection (WoSCC) database on December 31, 2024. The data analysis and graphical presentation were conducted using the Bibliometrix Package in R software and WoSCC.
    RESULTS: Public Health Nursing has had a rapidly growing impact on the field of public health nursing in terms of publications and citations. The most productive and collaborative country was the United States. "COVID-19," "vaccination," "older adults," "knowledge," "climate change," and "attitude" were the trending topics in recent years. According to the thematic map, more studies addressing the topics of "physical activity, obesity, adolescents" were required.
    CONCLUSION: The journal has an increasing contribution and impact on public health nursing studies. It was determined that the journal's publishing network was in good condition worldwide, and the thematic diversity was high. In addition, focusing on the topics that need further study can contribute to the field of public health nursing.
    Keywords:  Public Health Nursing; Web of Science Core Collection; bibliometrics; science mapping
    DOI:  https://doi.org/10.1111/phn.13574
  35. Medicine (Baltimore). 2025 May 16. 104(20): e42314
    Research trends in CAR-T cell therapy: A comprehensive bibliometric analysis highlighting cardiovascular toxicity and clinical implications.
    Daniyal Ameen, Ehsan Amini-Salehi, Sandeep Samethadka Nayak, Ashraf Ahmed, Alexis Pudimat, Amir Nasrollahizadeh, Kaveh Hosseini, Seyedeh Fatemeh Hosseini Jebelli, Azin Alizadeh Asl, Anthony Loc Nguyen.
       BACKGROUND: Chimeric antigen receptor T cell (CAR-T) therapy is an innovation in oncology, which provides targeted treatment alternatives for certain tumors. CAR-T therapy has been associated to adverse cardiovascular consequences despite its potential for therapeutic benefit. As research in this field expands rapidly, a bibliometric study is needed to map the current state of knowledge and highlight emerging areas of interest to guide future studies and optimize patient outcomes.
    METHODS: A comprehensive bibliometric analysis was conducted using the Web of Science Core Collection and PubMed to examine the literature on CAR-T cell therapy and its cardiovascular implications.
    RESULTS: The annual number of publications on CAR-T therapy and cardiovascular symptoms has steadily increased, experiencing a significant surge starting in 2018. The USA, China, and Germany emerged as the leading contributors. Key journals included Frontiers in Immunology and Blood, while highly cited journals were Lancet Oncology and the Journal of Clinical Oncology. Keyword analysis identified multiple myeloma, immunotherapy, and cytokine release syndrome as major research themes. The clustered map highlighted interconnected research areas, with a significant focus on multiple myeloma, combination therapy, cardiovascular magnetic resonance assessment, and novel therapeutic approaches.
    CONCLUSION: This bibliometric analysis provided a detailed overview of the research landscape on CAR-T cell therapy and its cardiovascular implications, identifying trends and gaps in knowledge. Recent research trends highlighted bispecific antibodies, CAR-T cell therapy, cardiovascular events, lymphoma, management, and outcomes as emerging focus areas. These keywords underscore the developing field of cardiac events, management, and outcomes in patients undergoing CAR-T cell therapy.
    Keywords:  CAR-T cell therapy; bibliometric analysis; cardiotoxicity; cardiovascular implications; immunotherapy; multiple myeloma; research trend
    DOI:  https://doi.org/10.1097/MD.0000000000042314
  36. J Stomatol Oral Maxillofac Surg. 2025 May 17. pii: S2468-7855(25)00196-X. [Epub ahead of print] 102410
    Frontiers and knowledge map of macrophage in wound healing: a scientometric and visualization analysis.
    Chongqing Yu, Chi Xu, Tao Wang, Jie Xu.
       BACKGROUND: The skin is a protective barrier against environmental elements. Given its position as the body's outermost layer, the skin is vulnerable to injury, often leading to what we commonly refer to as wounds. Wound healing presents a substantial and intricate challenge in both clinical practice and scientific investigation. Among the key players in wound healing, macrophages hold a central role as primary inflammatory cells. Therefore, this study aims to portray the knowledge landscape in the realm of macrophages in wound healing through bibliometric analysis.
    METHODS: Publications concerning macrophages in wound healing were comprehensively searched and selected from the Web of Science Core Collection(WOSCC) database.
    RESULTS: A total of 1998 publications from 71 countries/regions, focusing on macrophages in wound healing, were identified and published between 1987 and 2023. China and the USA ranked as the top two contributors in this field. Leading institutions included Shanghai Jiaotong University, the University System of OHIO, the University of California System, the University of Illinois System, and the University of Manchester. Chen L emerged as the most prolific author with the highest number of citations, while Werner S ranked in the top one in the average citations. Among journals, the Journal of Investigative Dermatology had the most publications, while Wound Repair and Regeneration was the most cited. Noteworthy keywords in this area encompass antibacterial, nanoparticles, hydrogel, and antioxidant. The research focus has shifted from traditional mechanisms of wound healing to the advanced application of biomaterials. Emerging hotspots in research center around biomaterials, with keywords like 'hydrogel,' 'nanoparticles,' 'inflammation,' 'macrophage polarization,' and 'antibacterial' gaining prominence.
    CONCLUSION: Collectively, hydrogel stands out as a promising treatment approach for wound healing. This study offers an extensive overview of research on macrophages in wound healing from 1987 to 2023, utilizing bibliometric analysis, providing readers with a valuable reference to steer future research endeavors.
    Keywords:  bibliometrics; inflammatory cells; macrophages; scientometrics; visualization; wound healing
    DOI:  https://doi.org/10.1016/j.jormas.2025.102410
  37. Discov Oncol. 2025 May 19. 16(1): 809
    Bibliometric visualization of hepatocellular carcinoma and metabolic syndrome research: trends and emerging areas.
    Kang Chen, Qianye Feng, Haipeng Liu.
      A growing body of research has highlighted the increasing relevance of hepatocellular carcinoma (HCC) and metabolic syndrome (MetS). However, a comprehensive bibliometric visualization analysis on this topic remains lacking. In this study, we retrieved 310 related articles from the Web of Science Core Collection, spanning from January 1, 2014, to December 31, 2023. Using VOS viewer and Cite Space software, we analyzed the relationships among authors, journals, institutions, countries, keywords, and citations. Between 2014 and 2023, there has been a steady increase in publications on HCC and MetS, with the United States and China being the leading contributors in terms of publication volume. The visualization analysis revealed that obesity, insulin resistance, MAFLD, and liver cirrhosis are emerging areas in the intersection of HCC and MetS. Additionally, the international community is increasingly adopting the disease diagnosis term MAFLD, which, compared to NAFLD, shows improved diagnostic performance for predicting both hepatic and extra-hepatic outcomes. Furthermore, hypertension and cardiovascular diseases are emerging as promising new research fields.
    Keywords:  Bibliometrics; Hepatocellular carcinoma; Metabolic syndrome; Visualization
    DOI:  https://doi.org/10.1007/s12672-025-02518-y
  38. Gastroenterol Hepatol Bed Bench. 2024 ;17(4): 379-388
    Worldwide research on abdominal compartment syndrome: bibliometric analysis of scientific literature (1993-2022).
    Muhana Fawwazy Ilyas, Aldebaran Lado, Ardhia Fefrine Indarta, Bagus Aris Madani, Kristanto Yuli Yarso, Ida Bagus Budhi.
      Continuing studies related to Abdominal Compartment Syndrome (ACS) is imperative in terms of its significant effect on morbidity and mortality rates. To establish bibliometric analysis as a comprehensive review of ACS literature. The process encompasses many phases, such as delineating search terms, beginning and refining search results, creating preliminary statistics from the data, and performing data evaluation. Scopus database was selected as the primary source, and VOSviewer software was used to visualize author networks, country affiliations, journal affiliations, and keyword associations. The analysis was conducted on January 16th, 2023, and yielded a total of 855 documents spanning the period from 1993 to 2022. Studies on ACS showed an annual increase, but it has not yet reached a mature stage. United States leads the world in terms of the highest number of publications, h-index, citations, and the involvement of renowned authors and organizations. Through an analysis of less frequently used keywords, this study identified potential themes for future investigation, including histopathology, biological markers, interleukin 6, alanine aminotransferase, early diagnosis, scoring systems, the severity of illness indices, clinical practices, patient monitoring, preoperative evaluations, minimally invasive surgery, inter-method comparisons, multicenter studies, follow-up investigations, systematic reviews, and meta-analyses. While publications in ACS journals are crucial, they alone are not exhaustive, necessitating further research.
    Keywords:  Abdominal compartment syndrome; Bibliometric analysis; Digestive surgery; Research trend; Scopus
    DOI:  https://doi.org/10.22037/ghfbb.v17i4.2926
  39. J Thorac Dis. 2025 Apr 30. 17(4): 2014-2027
    A bibliometric analysis of malignant pleural mesothelioma from 2010 to 2023.
    Sheng Chen, Ce Zhao, Ruiqi Liu, Wenjie Jiao.
       Background: Malignant pleural mesothelioma (MPM) is an aggressive tumor originating from the mesothelial lining of the pleural cavity. It is characterized by extensive nodular pleural thickening and has a propensity to invade the pleural adipose tissue and adjacent chest structures. The prognosis is poor, with a median survival time rarely exceeding 12 months following diagnosis.
    Methods: This bibliometric analysis systematically assessed global trends in MPM research from 2010 to 2023 using 6,487 publications indexed in PubMed. Quantitative evaluations of publication metrics, international collaboration, and keyword co-occurrence networks were conducted using R software with the bibliometrix package. Network construction and thematic mapping were employed to analyze the temporal evolution of research topics.
    Results: The United States and Europe have played pivotal roles in this research, while contributions from China and Japan have been steadily increasing. Traditional treatment approaches and etiological studies are relatively well-established. Meanwhile, immunotherapy has emerged as a prominent focus of recent research.
    Conclusions: Future global collaboration in this field should be enhanced, as precision medicine related to immunology and genetics has the potential to transform the treatment landscape of MPM.
    Keywords:  Bibliometrics; immunotherapy; malignant pleural mesothelioma (MPM)
    DOI:  https://doi.org/10.21037/jtd-24-1778
  40. Front Neurol. 2025 ;16 1525669
    Research trends of facial nerve injury after cerebellopontine angle tumor: CiteSpace-based bibliometric analysis.
    Xinxin Li, Bing Bai, Beibei Nie.
       Background: A bibliometric analysis was conducted to understand the current research status and trends in facial nerve injury after cerebellopontine angle (CPA) tumors to identify new perspectives for future research.
    Methods: CiteSpace was used to visualize and analyze relevant literature included in the CNKI and WanFang databases, and the Web of Science Core Collection from 2015 to 2024. Chinese literature was deduplicated using NoteExpress.
    Results: A total of 7,021 studies was retrieved, showing a pattern of rapid increase in this research area over the past 10 years. Protection and management of the facial nerve in surgery and early recognition of facial nerve injury were the research hotspots and trends.
    Conclusion: This study emphasizes the importance of intraoperative protection and management of the facial nerve. Limited research has addressed the postoperative facial nerve injury from the perspective of functional rehabilitation and patient psychology. These areas need more attention and focused research.
    Keywords:  CiteSpace; bibliometric analysis; cerebellopontine angle; facial nerve; research trend; tumor
    DOI:  https://doi.org/10.3389/fneur.2025.1525669
  41. Cureus. 2025 Apr;17(4): e82339
    A Bibliometric Analysis of COVID-19 Publications Between January 2019 and February 2025 by Romanian Authors.
    Dragos Puia, Marius Ivanuta, Catalin Pricop.
      The coronavirus disease 2019 (COVID-19) pandemic, declared by the World Health Organization (WHO) on March 11, 2020, had profound global consequences, including significant mortality, economic disruption, and strain on healthcare systems. Romania was also severely affected, with Suceava County being dubbed the "Romanian Lombardy" due to its high infection rates. In response, Romanian researchers actively contributed to scientific literature on COVID-19, producing numerous publications addressing epidemiology, public health policies, and medical treatments. This study aims to analyze Romanian scientific contributions related to COVID-19 using bibliometric methods. A bibliometric analysis was conducted using Web of Science, focusing on publications from Romanian universities, hospitals, and medical organizations. Articles were selected based on relevance to medicine, while non-research publications such as editorials and book reviews were excluded. The study employed VOSviewer (available at https://www.vosviewer.com/) for co-authorship and keyword analysis, alongside CiteSpace (available at https://citespace.podia.com/) for citation burst analysis. Between January 2019 and March 2025, 4,720 COVID-19-related articles with at least one Romanian author were indexed in Web of Science. After applying the inclusion criteria, 336 articles remained. The most productive authors were from Dunărea de Jos University, Galați, and the University of Oradea. Most studies were published in MDPI journals, with predominant research areas including internal medicine, pharmacology, and experimental medicine. Keyword analysis highlighted major research themes such as COVID-19 impact, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and pandemic response. Romanian research significantly influenced public health policies, guiding pandemic management strategies. The crisis accelerated digital healthcare adoption, including telemedicine services. Biomarkers such as C-reactive protein (CRP), interleukin-6 (IL-6), and lactate dehydrogenase (LDH) were identified as predictors of COVID-19 severity. Additionally, the pandemic had severe psychological and social consequences, particularly among vulnerable populations. This bibliometric analysis underscores the substantial role of Romanian researchers in the global fight against COVID-19 and the lasting impact of their contributions. Understanding Romania's scientific contribution to COVID-19 literature helps assess the country's research impact, identify strengths in key areas, and highlight opportunities for international collaboration in pandemic-related studies.
    Keywords:  bibliometric analyses; coronavirus infectious disease; covid-19 outbreak; romanian population; sars-cov-2
    DOI:  https://doi.org/10.7759/cureus.82339
  42. Quant Imaging Med Surg. 2025 May 01. 15(5): 3993-4013
    Bibliometric analysis of the application of artificial intelligence in orthopedic imaging.
    Xiao Huang, Fei Han, Yong-Feng Chen, Qiang Sun, Jian-Wei Guo, Zi Ye, Wei Qi, Da-Wei Zhang.
       Background: With the development of artificial intelligence (AI) and the increasing significance of imaging in orthopedics, the application of AI in the field of orthopedic imaging is becoming increasingly extensive. Previous studies show that the application of AI-based orthopedic imaging may break the traditional model of the field. As a result, relevant research has received attention, and numerous articles have been published. Through bibliometric analysis, this study summarized the knowledge structure of AI-based orthopedic imaging and explored its potential research trends and focal points.
    Methods: In this study, literature on AI in the field of orthopedic imaging available in the Web of Science Core Collection (WoSCC) database from 1 January 2007 to 31 December 2024 was analyzed. In order to identify the main research topics and generate visual charts of countries, institutions, authors, and keyword networks, the search results were imported into VOSviewer and CiteSpace.
    Results: A total of 3,147 publications were analyzed, revealing a rapid increase in AI research in orthopedic imaging since 2007, with over 90% of studies published after 2017. The United States (US) and China dominate this field, with the US leading in citations and academic influence, and China demonstrating significant growth in productivity. Institutional analysis highlighted Harvard University and Stanford University as key contributors, reflecting their strong academic influence. Keyword analysis identified three main research focuses: (I) advancements in algorithm development, particularly deep learning (DL) methods such as convolutional neural networks (CNNs); (II) applications in orthopedic disease imaging, including osteoarthritis, osteoporosis, and total knee arthroplasty; and (III) innovations in multimodal fusion and three-dimensional (3D) imaging techniques. Emerging trends emphasize integrating imaging data with clinical biomarkers to improve diagnostic accuracy and therapeutic decision-making. These findings provide a comprehensive overview of AI's role in orthopedic imaging, emphasizing areas of high impact and potential future directions for research.
    Conclusions: The research on the application of AI in orthopedic imaging is a hot topic and indicates broad research prospects in the future. However, this study suggests that research teams should strengthen collaboration, especially international cooperation. Based on comprehensive analysis, the development of DL algorithms (especially CNNs), the use of AI in processing image data related to orthopedic diseases (segmentation, classification, and feature map extraction), and the expansion of AI imaging applications in different diseases are expected to become hotspots in future research on the application of AI in orthopedic imaging.
    Keywords:  Bibliometric analysis; artificial intelligence (AI); image; orthopedic
    DOI:  https://doi.org/10.21037/qims-24-1384
  43. Interact J Med Res. 2025 May 22. 14 e64829
    Application of Machine Learning and Emerging Health Technologies in the Uptake of HIV Testing: Bibliometric Analysis of Studies Published From 2000 to 2024.
    Musa Jaiteh, Edith Phalane, Yegnanew A Shiferaw, Lateef Babatunde Amusa, Hossana Twinomurinzi, Refilwe Nancy Phaswana-Mafuya.
       Background: The global targets for HIV testing for achieving the Joint United Nations Programme on HIV/AIDS (UNAIDS) 95-95-95 targets are still short. Identifying gaps and opportunities for HIV testing uptake is crucial in fast-tracking the second (initiate people living with HIV on antiretroviral therapy) and third (viral suppression) UNAIDS goals. Machine learning and health technologies can precisely predict high-risk individuals and facilitate more effective and efficient HIV testing methods. Despite this advancement, there exists a research gap regarding the extent to which such technologies are integrated into HIV testing strategies worldwide.
    Objective: The study aimed to examine the characteristics, citation patterns, and contents of published studies applying machine learning and emerging health technologies in HIV testing from 2000 to 2024.
    Methods: This bibliometric analysis identified relevant studies using machine learning and emerging health technologies in HIV testing from the Web of Science database using synonymous keywords. The Bibliometrix R package was used to analyze the characteristics, citation patterns, and contents of 266 articles. The VOSviewer software was used to conduct network visualization. The analysis focused on the yearly growth rate, citation analysis, keywords, institutions, countries, authorship, and collaboration patterns. Key themes and topics were driven by the authors' most frequent keywords, which aided the content analysis.
    Results: The analysis revealed a scientific annual growth rate of 15.68%, with an international coauthorship of 8.22% and an average citation count of 17.47 per document. The most relevant sources were from high-impact journals such as the Journal of Internet Medicine Research, JMIR mHealth and uHealth, JMIR Research Protocols, mHealth, AIDS Care-Psychological and Socio-Medical Aspects of AI, and BMC Public Health, and PLOS One. The United States of America, China, South Africa, the United Kingdom, and Australia produced the highest number of contributions. Collaboration analysis showed significant networks among universities in high-income countries, including the University of North Carolina, Emory University, the University of Michigan, San Diego State University, the University of Pennsylvania, and the London School of Hygiene and Tropical Medicine. The discrepancy highlights missed opportunities in strategic partnerships between high-income and low-income countries. The results further demonstrate that machine learning and health technologies enhance the effective and efficient implementation of innovative HIV testing methods, including HIV self-testing among priority populations.
    Conclusions: This study identifies trends and hotspots of machine learning and health technology research in relation to HIV testing across various countries, institutions, journals, and authors. The trends are higher in high-income countries with a greater focus on technology applications for HIV self-testing among young people and priority populations. These insights will inform future researchers about the dynamics of research outputs and help them make scholarly decisions to address research gaps in this field.
    Keywords:  AIDS; HIV; HIV prevention; HIV testing; application; bibliography; bibliometric; bibliometric analysis; content analysis; epidemiology; mHealth; machine learning; mobile health; quantitative; self-testing; sexually transmitted disease; technology
    DOI:  https://doi.org/10.2196/64829
  44. Discov Oncol. 2025 May 18. 16(1): 802
    Bibliometric analysis of current trends and emerging patterns in the application of nanomaterials for non-small cell lung cancer.
    Shanshan Cai, Weichang Yang, Hongquan Xing, Jiale Yang, Hongdan Luo, Xiaoqun Ye.
       BACKGROUND: Lung cancer is one of the most prevalent tumor diagnoses and a leading cause of cancer-related mortality worldwide. Among its two primary subtypes, non-small cell lung cancer (NSCLC) accounts for approximately 80-85% of all lung cancer cases. Over the past decade, a significant number of publications have explored the application of nanomaterials in NSCLC. This study aimed to comprehensively evaluate the current state and evolving trends in research focused on utilizing nanomaterials as potent diagnostic and therapeutic tools for NSCLC.
    METHODS: To identify all pertinent publications, we used the Web of Science Core Collection (WoSCC) database. Based on stringent inclusion and exclusion criteria, relevant publications were carefully selected. For the bibliometric and visual analyses, we employed VOSviewer (version 1.6.20), CiteSpace (version 6.1.6), and R-bibliometrix (version 4.3.2).
    RESULTS: Our analysis encompassed 1880 studies that fulfilled the inclusion criteria. We observed a steady increase in annual publications from 2014 to June 22, 2024. China, the USA, and India have emerged as leading nations in this field. Notably, the Chinese Academy of Sciences and Wang J stood out as the most influential institutions and authors, respectively. Most publications are featured in The International Journal of Nanomedicine. The keywords used in these publications were closely tied to non-small cell lung cancer and nanomaterials. In the past three years, "green synthesis" exhibited the highest burst strength, while "immune response" and "nanocrystal" represented emerging areas of intense research interest.
    CONCLUSION: Through our exhaustive analysis, we synthesized the current research trends and emerging landscapes of nanomaterials in NSCLC. We characterized the publication patterns, pinpointed the most influential nations, institutions, authors, journals, and hot topics related to nanomaterial applications in NSCLC, and proposed potential avenues for future development.
    Keywords:  Bibliometric analysis; Nanomaterial; Non-small cell lung cancer; Research trend; Visualization
    DOI:  https://doi.org/10.1007/s12672-025-02602-3
  45. Stud Health Technol Inform. 2025 May 15. 327 823-827
    AI-Powered Affiliation Insights: LLM-Based Bibliometric Study of European Medical Informatics Conferences.
    Ehsan Bitaraf, Maryam Jafarpour.
      This study employs Large Language Models (LLMs) to analyze bibliometric data from European Medical Informatics conferences from 1996 to 2024. By enhancing traditional methods with LLM-based techniques, the researchers significantly improved affiliation extraction accuracy. The analysis reveals trends in publication volume, author impact, and institutional collaborations across Europe. Key findings include the identification of leading contributors, visualization of collaboration networks, and mapping of geographical and institutional centers of excellence. The study highlights the potential of LLMs in bibliometric analysis, offering deeper insights into research trends and collaborations while addressing challenges in data standardization and computational resources.
    Keywords:  Bibliometrics; Collaboration Networks; European Conferences; Large Language Models; Medical Informatics
    DOI:  https://doi.org/10.3233/SHTI250474
  46. J Thorac Dis. 2025 Apr 30. 17(4): 2537-2562
    A bibliometric analysis of the literature published on autophagy, ferroptosis, necroptosis, and pyroptosis in cardiovascular disease from 2009 to 2023.
    Yan Zhang, Tianyi Long, Bo Wei, Huan Zhou, Xinhai Yin, Zhangrong Chen, Pietro Di Fazio, Wei Li, Haiyan Zhou.
       Background: Programmed cell death (PCD) plays a pivotal role in the development and progression of cardiovascular disease (CVD), which remains the leading cause of mortality worldwide. Among the various types of PCD, autophagy, ferroptosis, necroptosis, and pyroptosis have garnered increasing attention due to their involvement in inflammation, oxidative stress, and cardiomyocyte survival. Although numerous studies have explored the underlying mechanisms of these pathways, their therapeutic potential in clinical practice remains limited. With the rapid growth of publications in this field, a comprehensive understanding of research trends and influential studies is essential to guide future investigations. This study aimed to characterize the progress and research hotspots of autophagy in CVD, ferroptosis in CVD, necroptosis in CVD, and pyroptosis in CVD through a bibliometric analysis to provide a comprehensive overview of PCD in CVD.
    Methods: Publications from January 1, 2009, to December 31, 2023, were analyzed using the "bibliometrix" R package to assess research output, key contributors, and influential journals in each field.
    Results: For the topic of autophagy in CVD, 6,426 articles published by 4,891 institutions from 90 countries/regions were retrieved. For the topic of necroptosis in CVD, 393 articles from 616 organizations in 53 countries/regions were retrieved. For the topic of pyroptosis in CVD, 640 publications from 754 institutions in 48 countries/regions were retrieved. Finally, for the topic of ferroptosis in CVD, 687 articles from 827 institutions in 49 countries/regions were retrieved. Key contributors included Adriana A (22 publications on necroptosis), Ge J, and Ye B (8 publications each on pyroptosis), and Ren J (lead contributor in autophagy and ferroptosis, with 120 and 10 publications, respectively). The most frequently co-cited journals were Cell, Nature, Free Radical Biology and Medicine, and the Journal of Biological Chemistry.
    Conclusions: This bibliometric analysis highlights the growing interest in PCD in CVD research, with autophagy and pyroptosis being the central themes. Future studies should examine therapeutic strategies targeting ferroptosis and necroptosis to improve CVD treatment. The findings provide a roadmap for researchers to navigate emerging research hotspots and foster interdisciplinary collaboration.
    Keywords:  Autophagy; cardiovascular disease (CVD); ferroptosis; pyroptosis
    DOI:  https://doi.org/10.21037/jtd-2025-682
  47. Nat Prod Res. 2025 May 22. 1-12
    GABAergic receptors and essential oils in anxiety and depression: a scientometric analysis.
    Jaqueline Kappke Zambianchi, Marjorie Benegra.
      This review aims to map and analyse scientific production on the effect of essential oils and their isolated compounds on GABAergic receptors with a focus on the treatment of anxiety and depression. Publications were selected from the Web of Science following the PRISMA guidelines from October 1945 to March 2024. Analysis of publication trends, geographic distribution, keywords, and influential articles was carried out using the CiteSpace and Bibliometrix tools. The results indicate that research on the topic is a recent trend, with only eight articles published before 2003 and a significant increase in publications during the SARS-CoV-2 pandemic. The main areas of interest were Medicinal Chemistry, Plant Sciences, and Integrative and Complementary Medicine, with Brazil and China leading the publications. The study also highlights a growing interest in scientifically validating natural therapies for safer and more effective treatment options.
    Keywords:  Complementary therapy; aromatherapy; bibliometric analysis; mental health; neurotransmitters
    DOI:  https://doi.org/10.1080/14786419.2025.2505610
  48. Front Oncol. 2025 ;15 1527091
    Effectiveness of herbal medicine for liver cancer treatment as revealed by a bibliometric and visualization analysis.
    Yusha Shi, Juwei Wang, Yahui Zhang, Kai Wu, Yibo Zhu, Kaiwen Yan, Qin Ouyang.
       Background: Liver cancer is highly prevalent worldwide. However, current medical treatments remain insufficient. Although herbal medicine has a long history and extensive expertise in treating liver cancer, the literature in this field has not been thoroughly explored. This study aims to assess and analyze the distribution patterns and key research areas of publications concerning herbal medicine for liver cancer.
    Methods: Literature on herbal medicine and liver cancer published between January 1, 2008, and September 28, 2024, was collected for this research. Excel, CiteSpace 6.4.R1, VOSviewer 1.6.20, Scimago Graphica, and Bibliometrix 4.1 were used for data analysis.
    Result: The study examines 634 academic articles on herbal medicine for liver cancer, with the majority contributed by Chinese researchers, particularly from Shanghai University of Traditional Chinese Medicine. Wang Ning is the most productive author, possessing the highest h-index. The JOURNAL OF ETHNOPHARMACOLOGY has the most publications and the highest h-index. Journals publishing on herbal medicine and liver cancer are primarily in the fields of molecular biology and immunology, whereas the cited journals are mainly in the fields of environment, toxicology, and nutrition. Keyword clustering analysis indicates that "NF kappa B" and apoptosis have long been the main research topics in this field. Analysis of emergent words suggests that "network pharmacology", antioxidants, "adjuvant therapy", and "molecular docking" may become significant research topics in the near future.
    Conclusion: This analysis provides a comprehensive overview of the current status, primary focuses, and emerging trends in research related to herbal medicine and liver cancer.
    Keywords:  CiteSpace; VOSviewer; bibliometrics; herbal medicine; liver cancer
    DOI:  https://doi.org/10.3389/fonc.2025.1527091
  49. Medicine (Baltimore). 2025 May 16. 104(20): e42015
    Bibliometric analysis of hepatocellular carcinoma and tyrosine kinase inhibitors.
    Wurihan Wu, Hejun Mao, Jian Song, Fan Yang.
       BACKGROUND: Hepatocellular carcinoma (HCC) is a common malignant tumor globally and in China, and its incidence and mortality rate are increasing year by year, and it faces many challenges and difficulties in treatment. Tyrosine kinase inhibitors (TKIs) have important roles in cell growth, proliferation, and differentiation, and have now become important drugs for cancer treatment. There are no bibliometric studies on liver cancer and TKIs to date.
    METHODS: We retrieved 2848 records from the Web of Science™ Core Collection (WoSCC) database and analyzed them scientifically and metrically using CiteSpace and VOSviewer in terms of temporal and spatial distributions, author distributions, journal distributions, references, and keywords.
    RESULTS: From January 1, 2004, to December 31, 2023, the WoSCC database documented 2848 publications related to tyrosinase inhibitors in HCC, comprising 2151 articles and 697 reviews. This literature involved 80 countries and regions, 3265 institutions, and 16,653 authors. Analysis shows a steady increase in publications annually since 2004, divided into 3 phases: 2004 to 2010 with fewer than 100 papers annually, suggesting minimal research attention; 2011 to 2019 with gradual growth, indicating increasing research interest; and a rapid surge post-2020, peaking in 2023, signaling heightened global interest in this field.
    CONCLUSION: Our bibliometric analysis on TKIs and HCC spans years, countries, institutions, authors, disciplines, and journals. Since 2004, this field has gained attention, with current research focusing on inflammatory and immune mechanisms, associated diseases, cytokines, and TKIs' applications in liver cancer treatment, including combination therapies. These areas signify emerging research directions.
    Keywords:  bibliometric analysis; hepatocellular carcinoma; tyrosine kinase inhibitors
    DOI:  https://doi.org/10.1097/MD.0000000000042015
  50. Front Oncol. 2025 ;15 1420517
    Current status and trends of machine learning applied in clinical research of gastric cancer from 2004 to 2023: global bibliometric and visual analysis.
    Xinyi Wang, Chao Wu, Siqing Yue, Mengyuan Zhou, Enba Zhuo, Xin Wu, Yafen Wang, Bangjie Chen, Fan Wang.
       Background: Gastric cancer is a serious disease that threatens human life; early diagnosis and treatment have been the focus of many studies. With advancements in imaging evaluation and machine learning, early detection and treatment of gastric cancer have become feasible. This study aimed to explore research trends and hotspots in the field of gastric cancer and machine learning through bibliometric analysis and to provide new insights for related clinical applications.
    Methods: Literature on gastric cancer and machine learning published from 2004 to 2023 was retrieved from the Web of Science database. Microsoft Excel 2019 was used for statistical analysis of influential articles, journals, authors, organizations, countries (regions), and co-citation references in this research domain. VOSviewer (version 1.6.16) and CiteSpace (version 5.8.R3) were utilized to visualize the corresponding data.
    Results: We analyzed and evaluated 425 articles authored by 2,899 researchers from 825 organizations across 52 countries (regions). The People's Republic of China, the Chinese Academy of Sciences, and the University of the Chinese Academy of Sciences were identified as leaders in this field. The article "Genome-wide cell-free DNA fragmentation in patients with cancer," published in Nature, was the most frequently cited work. The diagnosis and treatment of gastric cancer have consistently been research hotspots, with a shift in focus from laboratory-based studies to clinical applications. This trend highlights the transition from etiology-oriented research to studies emphasizing treatment and practical applications.
    Conclusions: This study offers a comprehensive visual analysis of research on gastric cancer and machine learning, representing the most detailed bibliometric study in this domain. With the continuous advancement of research, artificial intelligence-assisted early diagnostic methods for gastric cancer and corresponding treatment strategies may emerge as a pivotal direction for future research in this area.
    Keywords:  bibliometrics; diagnosis; gastric cancer; global trends; machine learning; treatment
    DOI:  https://doi.org/10.3389/fonc.2025.1420517
  51. Arch Microbiol. 2025 May 19. 207(7): 149
    Current status and future prospects of microalgae-based degradation of spent lubricant oil hydrocarbon towards environmental sustainability: a mini review and bibliometric analysis.
    Stella B Eregie, Isaac A Sanusi, Olaniran O Ademola.
      The biodegradation of spent oil waste (SOW) using bacteria and fungi has been actively researched over the years. Only recently has the use of microalgae for the treatment of SOW attracted significant attention. This review aims to highlight the biodegradative capabilities of microalgae as well as provide a comprehensive bibliometric analysis to assess current research activities and trends in microalgae-based biodegradation of SOW. The bibliographic data exported from Dimensions database was analyzed using VOSviewer, focusing on various aspects such as document types, publications, subject categories, sources, countries, authors, organizations, and cited articles. The results obtained showed a remarkable increase (80.23%) in the number of article publications from 2005 to 2023 in this field of research. China (887 publications), Environmental Science (3571 publications), Bioresource Technology (249 publications) and Harbin Institute of Technology (72 publications), were the most productive country, subject category, journal, and organization, respectively, publishing articles in this field of research. The review also discussed SOW hydrocarbons ranging from alkanes, aromatic compounds to polychlorinated compounds and the mechanism of degradation of these compounds by microalgae. Overall, the review provided useful insight on microalgae SOW degradation, current research direction and the prospect of using microalgae in environmental remediation and sustainability.
    Keywords:  Microalgae: biodegradation: environment: bibliometric; Spent oil waste
    DOI:  https://doi.org/10.1007/s00203-025-04332-0
  52. Cureus. 2025 Apr;17(4): e82451
    Publication Volume and Equity in Competitive Surgical Residency Programs: A Bibliometric Analysis of the 2023-2024 Match.
    Garrett Dyess, Maxon Bassett, Noah Baker, Christian Cooper, Isabella Dinelli, Qays Aljabi, Ryan McIlwain, Joshua Baroody, Danner W Butler, Ben Sotello, Michael Rallo, Neil Goldsmith, Benjamin Dribbus, Harris Bolus, Charles Ogles, Ivy Nguyen, Jai Thakur, Nitin Agarwal, Phillip V Gordon, Richard P Menger.
      The "Charting Outcomes in the Match" report by the National Resident Matching Program compiles data on abstracts, presentations, and publications (APPs) but does not specify the number of peer-reviewed publications. Prior research indicates discrepancies between the number of APPs and peer-reviewed publications. This study aimed to characterize the drivers of heightened publication rates among applicants who match into competitive surgical residencies.A retrospective cohort comparison study was conducted from October 2023 to January 2024. Data were extracted using publicly available information. An institutional review board waiver was obtained from the University of South Alabama. All applicants in the United States who successfully matched in 2023 into orthopedic surgery, vascular surgery, otolaryngology, plastic surgery, or neurosurgery were investigated. Extracted data included matched specialty, sex, graduating from a top-40 National Institutes of Health (NIH)-funded medical school, attending residency at the same institution where one graduated, additional degree, and matching into a top-40 Doximity-ranked residency program. The primary outcome was the number of peer-reviewed publications by matched applicants in each specialty. Secondary outcomes assessed the impact of demographic factors on publication output, the distribution of top 10th percentile publishers by specialty, the proportion of individuals with zero publications, and the H-index of published applicants. Attending a top-40 NIH-funded school was associated with increased publication output, with odds ratios (ORs) of 3.31 (95% confidence interval (CI) = 2.14-4.47, p < 0.001). ORs represent the strength of association between predictor variables and publication metrics, with values above 1.0 indicating positive associations. This association was higher for neurosurgery (OR = 7.76, 95% CI = 5.55-9.76, p < 0.001) and plastic surgery (OR = 3.87, 95% CI = 1.98-7.77, p < 0.001). Conversely, matching into orthopedic surgery (OR = 1.09, 95% CI = 1.04-1.15, p < 0.001) or vascular surgery (OR = 1.07, 95% CI = 0.94-1.22, p < 0.001) predicted admission without having published a peer-reviewed paper. Neurosurgery applicants had a significantly higher H-index compared to other specialties. Neurosurgery and plastic surgery admitted applicants with more peer-reviewed publications and fewer with zero publications compared to orthopedic, vascular, and otolaryngologic programs. High publication rates were also predicted by holding a non-medical postgraduate degree and graduating from a top-40 NIH-funded medical school, raising equity concerns due to differences in research opportunities and additional degrees.
    Keywords:  bibliometric analysis; competitive specialties; medical education; nih funding; publication disparities; research productivity; residency match; usmle step 1
    DOI:  https://doi.org/10.7759/cureus.82451
  53. BMJ. 2025 May 20. 389 r1047
    Citations of retracted articles will no longer count towards impact factor.
    Elisabeth Mahase.
      
    DOI:  https://doi.org/10.1136/bmj.r1047
  54. Expert Rev Clin Immunol. 2025 May 21.
    Thyroid Eye disease in the Biologic Era: a 40-year paradigm shift in nonsurgical therapeutic strategies.
    Erqian Wang, Zuyi Yang, Zhixuan Xie, Dianzhe Tian, Haiyan Xu, Hui Li, Youxin Chen.
       BACKGROUND: Over the last four decades, there has been a progressive increase in the number of publications and citations on research related to thyroid-associated ophthalmopathy (TAO) nonsurgical treatment across many countries/regions, institutions, and authors, with a special focus on biological immunotherapy.
    RESEARCH DESIGN AND METHODS: Examing 1600 publications collected from the Web of Science Core Collection database on TAO research from 1983 to 2023, our bibliometric analysis evaluated various bibliometric indicators, among which some important subtopics were identified and further discussed and reviewed.
    RESULTS: The study showed that novel insights into the pathogenesis of TAO and new immunological targets for nonsurgical treatments were the major research focus over the past 40 years. Especially, targeted biological immunotherapies were on the rise, promoting treatments efficacy and patients' quality of life.
    CONCLUSIONS: Our study provided a thorough overview and visual presentation of the evolutionary landscape and emerging frontiers for nonsurgical treatment of TAO surrounding its immunological mechanism and therapeutic strategy. It also shed light on its global collaboration patterns, current trends and research hotspots, hopefully to facilitate collaborative initiatives and guiding future research.
    Keywords:  Biologics; nonsurgical treatment; rituximab; teprotumumab; thyroid-associated ophthalmology; tocilizumab
    DOI:  https://doi.org/10.1080/1744666X.2025.2509582
  55. Front Psychiatry. 2025 ;16 1435612
    A bibliometric analysis of the current state of research on family interventions for ASD.
    Xuhui Meng, Xue Zhou, Jiahui Luo, Jiaxia Li, Li Zhou, Yuhan Zhang.
      In recent years, family intervention has become a hot research direction in the field of autism spectrum disorder (ASD) treatment. A large amount of research literature shows that family intervention is effective in ASD rehabilitation. Still, the concept of family intervention is vaguely defined, and there is a lack of descriptions of specific intervention programs and treatment pathways and a diversity of intervention programs have been reported. In this study, we conducted an econometric analysis of the literature on family intervention for ASD to clarify the concept of family intervention and to analyze and explore the research hotspots, effective family intervention models for ASD, intervention techniques, and possible future research directions in this field.
    Methods: A metrological analysis of the literature related to ASD family interventions on the Web of Science from 1987 to 2024 was conducted using CiteSpace software to map the network of countries/institutions, journals, authors, co-cited literature, and keywords in the field. The results were visualized and analyzed.
    Results: A total of 1,891 documents were retrieved. The United States (1,028) led in the number and relevance of publications, followed by Canada (254) and Australia (209). The trend of publications was upward. Baranek was the most published author (19) and the University of California System was the most published university. Developed countries dominate the research. According to the timeline graph, it can be learned that the current research hotspots in this field are mostly focused on early intervention in family-based, psychological stress in parents of children with autism.
    Conclusion: This visual analysis identifies the most influential institutions and countries, as well as cited journals and authors in the field of family therapy autism research. The direction of research in family therapy for autism should be to find effective treatments for autism based on the home environment, and currently, the most prominent family therapy for autism is telemedicine and parent-mediated intervention. The future direction of this research area could be taken by artificial intelligence techniques specifically applied to children with autism in a computer context.
    Keywords:  CiteSpace; autism spectrum disorders; bibliometrics; early intervention; family interventions
    DOI:  https://doi.org/10.3389/fpsyt.2025.1435612
  56. Epidemiologia (Basel). 2025 May 05. pii: 23. [Epub ahead of print]6(2):
    Studying the Role of Vegetarianism as a Potential Strategy for Cancer Prevention and Treatment, a Bibliometric Analysis.
    Maria Chrysafi, Maria Gialeli, Constantinos Giaginis, Andreas Y Troumbis, Georgios K Vasios.
      Vegetarianism, as a dietary pattern, is characterized by animal product avoidance and increased consumption of fruits, vegetables, whole grains, and legumes. It has been associated with health benefits, both physical and psychological, and has raised interest as a potential strategy for cancer prevention and treatment, which remains one of the leading causes of morbidity and mortality worldwide, demanding continual exploration of novel approaches.
    BACKGROUND/OBJECTIVES: This study aims to describe trends in scientific publications about the relationship between vegetarianism and cancer and to highlight research gaps using bibliometric analysis.
    METHODS: The methodology includes comprehensive research of three literature databases. After combining and cleaning these data, a final sample of 3427 studies was obtained that was analyzed using the Bibliometrix-R package.
    RESULTS: The results indicate a continuously growing production of scientific publications. The most impactful sources, authors and their collaborations were identified. Author keywords, their co-occurrence network, and thematic trends were studied.
    CONCLUSIONS: Through synthesizing and critically evaluating insights from the scientific literature, we aim to contribute to the understanding of the potential benefits of vegetarianism in cancer prevention and management. However, due to the complexity of the topic, the results are often contradictory and could be used as a starting point for further research.
    Keywords:  Bibliometrix; bibliometric analysis; cancer; neoplasms; vegetarian diet; vegetarianism
    DOI:  https://doi.org/10.3390/epidemiologia6020023
  57. Arch Dermatol Res. 2025 May 20. 317(1): 771
    A comprehensive bibliometric analysis of the association between atopic dermatitis and depression (1994-2024).
    Yan Yang, Jun-Xiong Li, Zi-Ling Wang, Si-En Zhu, Jian-Zhou Xie.
      In recent decades, the prevalence of atopic dermatitis (AD) has dramatically risen due to modern environmental exposures and drastic lifestyle changes. Furthermore, many studies emphasize that the prevalence of mental health issues, such as depression and anxiety, is much higher among patients with AD compared to the general population. Consequently, there is an urgent imperative to delve into emerging research trends and focal points concerning the association between AD and depression. By analyzing the literature on the correlation between AD and Depression in the Web of Science Core Collection (WoSCC) over the past three decades, our study aims to investigate the key research areas and trends related to the connection between AD and depression through bibliometric analysis, offering useful insights for future researchers in this area. Publications from January 1, 1994, to December 31, 2024, were retrieved from WoSCC on January 5, 2025, and visualized with Excel and Vosviewer software. Summing up to 729 papers were included, authored by 3,670 individuals. The United States, Germany, and the United Kingdom were prominent in researching the link between AD and depression, with the US publishing the highest number of papers-216 in total. Jonathan I. Silverberg stood out as the most prolific author in this field. Keywords visualization analysis revealed that "atopic dermatitis" and "depression" were core topics. It is noteworthy that there has been a significant evolution in research emphasis over time, with studies of AD associated with depression moving from early "pruritus" "psoriasis", and "stress" studies, gradually transitioning into the field of adolescent mental health, suggesting that society's interest in dermatologic conditions and their psychological impact is gradually extending from purely physical symptoms to the broader implications of mental health and quality of life. A thorough bibliometric analysis was initially performed to outline the current state and knowledge framework of the connection between AD and depression, aiming to offer guidance and new insights for future research in this area.
    Keywords:  Atopic dermatitis; Bibliometrics; Depression; Hotspots; VOSviewer; Visualization
    DOI:  https://doi.org/10.1007/s00403-025-04269-w
  58. Front Pharmacol. 2025 ;16 1571879
    Knowledge landscape of macrophage research in liver fibrosis: a bibliometric review of the literature from WoSCC.
    Yanbo Li, Zhengmin Cao, Yanping Lu, Chao Lei, Wenliang Lyu.
      Recent insights into the immune response in fibrosis have provided valuable perspectives for the treatment of liver fibrosis. Macrophages, as the most abundant immune cells in the liver, are key drivers of liver fibrosis. They are extensively involved in tissue damage, chronic inflammation, and the progression and regression of liver fibrosis. This study aims to conduct a bibliometric analysis and literature review on the mechanisms by which macrophages contribute to liver fibrosis. Specifically, we analyzed a bibliometric dataset comprising 1,312 papers from 59 countries, 1,872 institutions, and 9,784 authors. Keyword co-occurrence analysis identified key research hotspots, including the role of macrophage subtypes in obesity-related metabolic disorders, the crosstalk between macrophages and hepatic stellate cells through mechanoimmunology, emerging strategies for immune modulation targeting macrophages to promote fibrosis regression and liver regeneration, and new discoveries regarding macrophage crosstalk with other immune cells. In conclusion, this study provides a visual analysis of the current research landscape, hotspots, and trends in the field of macrophages and liver fibrosis, and discusses future directions for further exploration in this area.
    Keywords:  bibliometrics; liver fibrosis; macrophages; pharmacological mechanism; visualization
    DOI:  https://doi.org/10.3389/fphar.2025.1571879
  59. BMJ Open. 2025 May 22. 15(5): e093157
    Female authorship trends in a high-impact Canadian medical journal: a 10-year cross-sectional series, 2013-2023.
    Christie Rampersad.
       IMPORTANCE: Women are under-represented in senior roles within academic medicine, including as authors in high-impact journals.
    OBJECTIVE: To examine trends and predictors of female authorship in the Canadian Medical Association Journal (CMAJ) as the only high-impact Canadian journal over a 10-year period to understand gender balances in Canadian academic publishing.
    DESIGN: This cross-sectional study analysed trends and predictors of female authorship in articles published in CMAJ from 1 January 2013 to 31 December 2023.
    SETTING: Data were extracted from PubMed for CMAJ, the only high-impact Canadian medical journal (impact factor ≥10). Data extraction used the RISmed package in R Studio.
    PARTICIPANTS: The study included articles published in CMAJ within the specified period. Author gender was predicted using the validated Genderize.io software. Articles where the gender of the authors could not be predicted were excluded from analysis.
    MAIN OUTCOMES AND MEASURES: The co-primary outcomes were proportions of female first and last authors. Statistical analyses included χ2 tests comparing proportions, Jonckheere and linear regression models to evaluate trends. Among multiauthor articles, multivariable logistic regression models assessed predictors of female first and last authorship.
    RESULTS: From 5805 included articles, women comprised 47% of first authors and 43% of last authors (p<0.001), both significantly lower than men (p<0.001). Female first authorship increased by 17.7% and female last authorship by 10.5% over the study period (both p<0.05 for trend), reaching a majority (58%) and near parity (48%) in 2023, respectively. Female editor-in-chief and higher proportion of female coauthors were associated with higher odds of female first and last authors; female last authors were additionally associated with higher odds of female first authors.
    INTERPRETATION: Women were under-represented in authorship overall, though female first and last authorship increased over time, with first authorship exceeding parity in recent years and last authorship nearing equal representation. Female editors-in-chief and a higher proportion of female coauthors were associated with greater female first and last authorship, while female last authorship was additionally associated with higher odds of female first authorship. These findings provide insight into authorship trends in a high-impact Canadian medical journal and may inform future efforts to support gender equity in academic publishing.
    Keywords:  Health Equity; Physicians; Sexual and Gender Minorities
    DOI:  https://doi.org/10.1136/bmjopen-2024-093157
  60. Discov Oncol. 2025 May 23. 16(1): 889
    The role of programmed cell death in renal cancer: a bibliometric perspective (1998-2024).
    Liang Hong, Chun Zhao, Tingping Wu, Xiaorong Hu, Xueyao Li, Lu Li.
       OBJECTIVE: This bibliometric study aimed to map the global research landscape of programmed cell death (PCD) in renal cancer, delineating publication trends, influential authors, contributing regions, and thematic shifts between 1998 and 2023 year.
    METHODS: We retrieved 5, 134 records from the Web of Science Core Collection (1998-2023) using comprehensive keywords encompassing "renal cancer," "programmed cell death," and related synonyms. After applying inclusion and exclusion criteria, we conducted co-citation, keyword, and cluster analyses with CiteSpace (v.6.3.R2) and VOSviewer (v.1.6.20) to identify major research fronts, collaboration networks, and thematic clusters.
    RESULTS: Findings revealed a progressive increase in publications, notably accelerating after 2010 in tandem with the rise of immunotherapeutic strategies and targeted molecular interventions. China and the United States emerged as leading contributors, while journals such as Cancer Research and Clinical Cancer Research dominated in both publication frequency and citation impact. Authors including Kwon Taeg Kyu and Dahiya Rajvir significantly shaped foundational apoptosis research. Keyword and cluster analyses demonstrated a shift from earlier apoptosis- and angiogenesis-focused studies toward intersections of metabolic reprogramming, immune infiltration, and newer cell death modalities (e.g., ferroptosis, pyroptosis). High-impact papers underscored immunotherapy's pivotal role in modulating cell death pathways and informing novel combination regimens.
    CONCLUSION: PCD research in renal cancer has evolved into a dynamic, interdisciplinary domain integrating immunology, molecular targeting, and multi-omic profiling. Future development of the field aimed at refining precision therapies that exploit diverse cell death mechanisms and thereby improve clinical outcomes.
    Keywords:  Apoptosis; Immunotherapy; Molecular targeting; Programmed cell death; Renal cancer; Tumor microenvironment
    DOI:  https://doi.org/10.1007/s12672-025-02610-3
  61. Eur J Ophthalmol. 2025 May 19. 11206721251343653
    A bibliometric and visualized analysis of ischemic optic neuropathy from 2014 to 2024.
    Puying Wei, Xizhe Wang, Jinming Han, Xuxiang Zhang.
      ObjectiveIschemic optic neuropathy (ION) is one of major causes of blindness or severe visual impairment. However, controversies persist regarding its pathogenesis, clinical features and management. This study aimed to conduct a bibliometric analysis to provide an assessment of current status and emerging trends in the field of ION.MethodsPublications spanning from January 2014 to Jun 2024 were retrieved, using the Web of Science Core Collection. Bibliometric and visualized analyses were performed employing the bibliometrix, CiteSpace and VOSviewer.ResultsA total of 776 papers met the inclusion criteria and a fluctuated publication trend was observed. The United States was the leading country. Research topics in ION field encompassed non-arteritic anterior ION (NAION), optical coherence tomography angiography, neuroprotection, optical coherence tomography, spine surgery, giant cell arteritis (GCA), optic disc diameter, peripapillary hyperreflective ovoid mass-like structures, vaccination, and branch retinal vein occlusion, based on the co-citation references analysis. The keywords "COVID-19", "oxidative stress", "inflammation" and "optic neuritis" experienced burst lasting until 2024.ConclusionDuring the past decade, advancements in in vivo imaging techniques are continually enhancing our understanding of the pathogenesis of ION and facilitating accurate diagnosis. NAION has been a prominent research topic, covering its pathogenesis, clinical features, and management. Studies on arteritic ION and GCA have garnered widespread attention, especially due to advances in treatments. Future research is warranted to identify standardized therapies for non-arteritic ION, potentially incorporating neuroprotective agents, and to formulate steroid-sparing treatment strategies aimed at preventing vision loss in arteritic ION, rather than merely addressing GCA.
    Keywords:  Bibliometric; CiteSpace; VOSviewer; giant cell arteritis; ischemic optic neuropathy; nonarteritic anterior ischemic optic neuropathy
    DOI:  https://doi.org/10.1177/11206721251343653
  62. F1000Res. 2025 ;14 201
    Mapping the landscape: A bibliometric analysis of AI and teacher collaboration in educational research.
    Arvind Nain, N S Bohra, Archana Singh, Rekha Verma, Rakesh Kumar, Rajesh Kumar.
       Background: This study intends to investigate the relationship between artificial intelligence and teachers' collaboration in educational research in response to the growing use of technologies and the current status of the field.
    Methods: A total of 62 publications were looked at through a systematic review that included data mining, analytics, and bibliometric methods.
    Result: The study shows a steady increase in the field of artificial intelligence and teacher collaboration in educational research, especially in the last few years with the involvement of the USA, China, and India. Education and information technology are the main contributors to this field of study, followed by an international review of open and distance learning research. The Scopus database was chosen for this study because of its extensive coverage of high-quality, peer-reviewed literature and robust indexing system, making it a dependable source for conducting bibliometric analyses. Scopus offers substantial information, citations tracking, and multidisciplinary coverage, which are critical for spotting publication trends, significant articles, major themes, and keywords in the area. The findings show that education and information technology make the most significant contributions to this sector, followed by international studies on open and distance learning.
    Conclusions: Over a three-year period, the average citation value is 12.44%. The education system, learning, e-learning, sustainability, COVID-19 issues, team challenges, organizational conflicts, and digital transformation are just a few of the topics it significantly contributes to. The study acknowledges its limitations and considers potential avenues for additional research. The results also emphasize important gaps in the literature, highlighting the necessity for more research. This information can help develop strategic approaches to address issues and take advantage of opportunities relating to artificial intelligence and teacher collaboration in higher education and research. The study's ultimate goal is to offer guidance for tactics that promote teachers' cooperation in educational research and the development of artificial intelligence.
    Keywords:  Artificial Intelligence; Bibliometric; Education; Teachers; Teaching
    DOI:  https://doi.org/10.12688/f1000research.160297.2
  63. Front Immunol. 2025 ;16 1581885
    Bibliometric analysis of traditional Chinese medicine in cancer treatment via immune system modulation (2015-2025).
    Youfeng Lei, Chunyan Chen.
       Objective: The application of Traditional Chinese Medicine (TCM) in treating cancer by regulating the immune system has garnered significant attention in the academic community. However, comprehensive quantitative analyses in this field remain limited. This study aims to assess the research progress and key trends over the past decade, providing a framework for future studies.
    Methods: A comprehensive literature search was conducted on the application of TCM in treating cancer by regulating the immune system from 2015 to 2025 using the Web of Science database. The search terms mainly included cancer, Traditional Chinese Medicine, immunity and so on. Data were analyzed and visualized using Origin, R software, VOSviewer, and CiteSpace.
    Results: A total of 2,459 articles were included in the analysis. The number of related publications has steadily increased since 2015. China leads in publication volume and plays a crucial role in international collaboration. The Journal of Ethnopharmacology is the leading journal in this field, publishing a substantial number of highly cited studies. Key research areas include keywords such as "apoptosis," "expression," "inflammation," "extract," "in vitro," "activation," "antioxidant," and "NF-kappa B," focusing on exploring the role, mechanisms, and efficacy of TCM in modulating immune responses.
    Conclusion: Research interest in TCM's role in treating cancer through immune system regulation continues to grow, underscoring its potential in cancer therapy. Current research primarily focuses on the mechanisms by which TCM treats cancer through the modulation of immune cell functions, inhibition of tumor immune evasion, and regulation of immune-related signaling pathways. It also explores its clinical applications and the potential for enhancing the efficacy of immunotherapy.
    Keywords:  activation; antioxidant; apoptosis; expression; extract; inflammation
    DOI:  https://doi.org/10.3389/fimmu.2025.1581885
  64. Plast Reconstr Surg Glob Open. 2025 May;13(5): e6821
    Plastic Surgery Research From Low- and Middle-income Countries Over a Decade: A Web of Science Analysis.
    Andrew Hannoudi, Jeffrey J Janis.
       Background: Research publications from low- and middle-income countries (LMICs) are underrepresented in the plastic surgery literature. Identifying trends in impactful research publications from LMICs can help guide strategies for more equitable contributions to the field from nations facing similar barriers to success.
    Methods: Using Web of Science, the top 100 most-cited plastic surgery articles published by researchers from LMICs over the past decade were collected. Trends in various factors, such as authorship contribution, country affiliation, and institutional affiliation were analyzed. Coauthorship collaborations were illustrated using VOSviewer.
    Results: The top 100 articles had a combined total of 3398 citations, ranging from 16 to 157 citations per article. India and Egypt accounted for 81% of publications, likely attributable to the research collaborations between these nations and high-income countries. Craniofacial surgery, which is performed at disproportionately higher rates in LMICs, was the main research focus in 22 of 100 publications.
    Conclusions: As plastic surgery continues to evolve worldwide, promoting the formation of partnerships between underrepresented LMICs and high-income countries will drastically improve the field. These findings provide a snapshot of key LMIC-based contributors to the plastic surgery literature, offering a resource that may be referenced by potential collaborators.
    DOI:  https://doi.org/10.1097/GOX.0000000000006821
  65. Cureus. 2025 May;17(5): e84528
    Prescription Digital Therapeutics Research Across Clinical, Engagement, Regulatory, and Implementation Domains: A Bibliometric and Thematic Study.
    Shaheen E Lakhan.
      Prescription digital therapeutics (PDTs) are Food and Drug Administration (FDA)-authorized software-based treatments designed to treat a range of conditions on the smartphone. Their development and deployment rely on four foundational scientific domains: clinical, engagement, regulatory, and implementation. However, the relative representation of these domains in the PDT literature has not been systematically characterized. We conducted a bibliometric and thematic analysis of PubMed-indexed articles published between 2020 and 2025 containing the term "prescription digital therapeutic(s)." Metadata and abstracts were extracted, cleaned, and analyzed using natural language processing for this review. Topic modeling was performed to identify key thematic areas, and each abstract was classified into one or more of the four foundational domains using a structured keyword heuristic framework. Trends in publication volume, authorship, domain co-occurrence, and thematic focus were visualized. Sixty-one unique articles met the inclusion criteria. Publication activity increased over time, peaking in 2022 and 2024. Most first authors were based in the United States, with industry-affiliated authorships predominating. The most frequently publishing journals were Frontiers in Psychiatry and Health Affairs (Millwood). Clinical science was referenced in 45 (74%) papers, followed by engagement science in 35 (58%), regulatory science in 28 (46%), and implementation science in 18 (29%). Only seven (12%) articles addressed all four domains. Topic modeling identified five major themes: substance use and cost modeling, regulatory frameworks, insomnia treatment, engagement strategies, and gamified pediatric interventions. Co-occurrence analysis revealed strong overlap between clinical and engagement domains, while regulatory and implementation science appeared less frequently in combination. The literature on PDTs remains concentrated in clinical and engagement domains, with limited attention to regulatory strategy and real-world implementation. Greater integration across all four scientific domains is needed to ensure that PDTs are not only effective but also scalable, fundable, and embedded into routine care.
    Keywords:  bibliometric analysis; clinical science; digital health; engagement science; implementation science; pdt; prescription digital therapeutics; regulatory science; software as a medical device; topic modeling 4o
    DOI:  https://doi.org/10.7759/cureus.84528
  66. Photodiagnosis Photodyn Ther. 2025 May 18. pii: S1572-1000(25)00168-1. [Epub ahead of print] 104636
    Bibliometric and visual analysis of retinal fibrosis research from 1993 to 2023.
    Jie Zhang, Yiting Qian, Yanyu Shangguan, Yu Gong, Yiyang Shu, Yimin Wang.
       BACKGROUND: Retinal fibrosis, a common pathological feature of various retinal diseases, significantly impairs vision. The mechanisms of retinal fibrosis are complex, with cytokine involvement playing a pivotal role. This article aims to elucidate the current research trends and key areas of focus in the study of retinal fibrosis.
    METHODS: Publications from "Web of Science core collection", "PubMed" and "Scopus" were analyzed using R Studio ("Bibliometrix" and "ggplot2" packages) for publication counts, geographic distribution, and collaborations, while "CiteSpace" and "VOSviewer" visualized institutional partnerships and keyword co-occurrence. The methodology follows the PRISMA 2020 guidelines strictly.
    RESULTS: In this analysis, a total of 1985 studies were analyzed. Key topics included "vitrectomy", "epiretinal membrane", "optical coherence tomography (OCT)", "macular membrane", and "macular hole". Keyword co-occurrence analysis emphased macular disease, fibrosis diagnosis, pharmacological treatment, and prognosis across various groups with cytokines as prominent research topics. Additionally, the findings suggested future research would focus on elucidating fibrosis mechanisms, advancing diagnostic techniques, and identifying potential drug targets. The journal "Retina" had the highest citation count for retinal fibrosis. The United States showed the greatest collaboration in retinal fibrosis research, particularly with China.
    CONCLUSIONS: Current retinal fibrosis research focused on OCT diagnostics, cytokine mechanisms, and associated diseases such as diabetic retinopathy and macular degeneration. Future research will explore the integration of artificial intelligence in treatment strategies and the mechanisms underlying post-anti-VEGF injection fibrosis.
    Keywords:  Fibrosis; cytokine; extraretinal matrix; myofibroblast; optical coherence tomography; retinal diseases; vegf
    DOI:  https://doi.org/10.1016/j.pdpdt.2025.104636
  67. Front Public Health. 2025 ;13 1592916
    Visualization analysis of poisoning-related research based on CiteSpace.
    Wen Zhu, Yao Xiao, LinShen Xie.
       Objective: Summarize the current status, hotspots, and frontier trends in poisoning research over the past decade using CiteSpace software, and provide direction for future research in toxicology and public health.
    Methods: Relevant literature published between 2015 and 2024 was retrieved from the China National Knowledge Infrastructure (CNKI) and Web of Science Core Collection. CiteSpace software was employed to conduct a visual analysis of poisoning-related research literature from the past decade.
    Results: A total of 5,644 Chinese articles and 14,985 English articles were included. High-frequency keywords in Chinese literature included "hemoperfusion" and "nursing" while high-frequency keywords in English literature included "exposure" "oxidative stress" and "identification." Keywords with strong betweenness centrality included "treatment," "blood purification" and "carbon monoxide." Recent emerging hotspots in Chinese literature were "liver function" and "oxidative stress" while in English literature, "gut microbiota" has recently gained attention.
    Conclusion: Poisoning-related research has shown an overall upward trend. The research hotspots in this field primarily include epidemiology, oxidative stress, clinical treatment, prognosis, and chemical substances (e.g., CO, paraquat). In-depth studies on gut microbiota and oxidative stress are expected to become future research trends in this field.
    Keywords:  CiteSpace; gut microbiota; oxidative stress; poisoning; visualization research
    DOI:  https://doi.org/10.3389/fpubh.2025.1592916
  68. J Inflamm Res. 2025 ;18 6349-6362
    Trends in Research on the P2X7 Receptor: A Bibliometric and Visualization Analysis.
    Chao Ren, Jingjing Zhang, Ting Yang, Yao Wang, Xiaoyu Song, Hanrui Wang, Wanchen Liu, Yakui Mou, Xicheng Song.
      The P2X7 receptor (P2X7R), activated by ATP, participates in mediating a variety of biological processes such as the release of inflammatory factors, thereby affecting the pathogenesis of numerous diseases. Despite its clinical significance, comprehensive bibliometric studies on P2X7R-related research remain scarce. To address this gap, we conducted a bibliometric investigation to quantify publication outputs, identify leading contributors, and map geographical distributions of P2X7R-related research, ultimately elucidating current research frontiers and emerging trends. Utilizing visualization techniques, complex bibliometric relationships were transformed into interpretable graphical representations. Our Web of Science query for "P2X7R" identified 4551 original research articles by 13,471 authors published since 1985. Publication volume demonstrated sustained growth, with China emerging as the predominant contributor in quantitative output (1871 articles) and the United States leading in international collaborations. Thematic mapping revealed two principal research areas: "P2X7R, inflammation, microglia" and "P2X7R, apoptosis, purinergic". Notably, "P2X7R, P2 receptors, oxidative stress" encompassed both motor and niche themes, thus representing the trajectory of future development potential. Through bibliometric and visualization analysis, we found that the literature related to P2X7R is on the rise and will enter a new stage of interdisciplinary integration development in the future.
    Keywords:  P2X7 receptor; VOSviewer; bibliometrix; web of science
    DOI:  https://doi.org/10.2147/JIR.S522380
  69. BMC Urol. 2025 May 21. 25(1): 132
    Metabolic syndrome and bladder cancer risk: a comprehensive evidence synthesis combining bibliometric and meta-analysis approaches.
    Yi Yuan, Tongpeng Liu, Yu Yao, Qingyue Ma, Lijiang Sun, Guiming Zhang.
       OBJECTIVE: This study employed bibliometric analysis to explore global research on metabolic syndrome (MetS) and bladder cancer (BC), focusing on characteristics and research trends. Additionally, a meta-analysis was conducted to comprehensively evaluate the association between MetS and its components with the risk of BC.
    METHODS: We conducted a comprehensive search of publications from 2002 to 2022 in the Web of Science Core Collection (WoSCC). Visualization analysis was performed using the Open Scientometrics Data Analysis and Visualization Platform, VOSviewer software and the R package "bibliometrix". For the meta-analysis, data from PubMed, Embase and the Cochrane Library up to March 22, 2022, were utilized. Literature from PubMed, Embase, Cochrane and Web of Science up to March 25, 2022, were retrieved, and data extraction was independently performed by two authors. A random-effects model was used to calculate pooled odds ratios (ORs) and 95% confidence intervals (95% CIs). Meta-analysis was conducted using RevMan 5.4 software.
    RESULT: In the bibliometric analysis, 147 papers were included, and information on countries, institutions, authors, journals and keywords from Web of Science was analyzed and visualized. For the meta-analysis, 11 studies involving 665,164 patients were included. The pooled analysis of six case-control studies showed that patients with MetS had a higher risk of BC compared to the non-MetS control group (OR = 1.62, 95% CI: 1.08-2.43, P < 0.01). Analysis of MetS components revealed that diabetes (OR = 0.44, 95% CI: 0.32-0.61, P < 0.01), low high-density lipoprotein (HDL) (OR = 0.29, 95% CI: 0.19-0.44, P < 0.01) and high triglycerides (OR = 0.59, 95% CI: 0.39-0.88, P < 0.01) were associated with an increased risk of BC. In contrast, hypertension (OR = 0.84, 95% CI: 0.62-1.12, P > 0.05) and obesity (OR = 0.8, 95% CI: 0.44-1.45, P > 0.05) showed no significant association with BC risk.
    CONCLUSION: This study provided valuable insights into the association between MetS and BC risk by identifying past research trends and hotspots. MetS and its components, such as diabetes, low HDL and high triglycerides, were associated with an increased risk of BC.
    Keywords:  Bladder Cancer; Cancer Risk; Diabetes; Dyslipidemia; Metabolic Syndrome
    DOI:  https://doi.org/10.1186/s12894-025-01812-9
  70. Front Res Metr Anal. 2025 ;10 1478317
    Production and impact of Italian researchers in physical-Sport education and sport pedagogy.
    Francesca D'Elia, Tiziana D'Isanto, Sara Aliberti, Rosario Ceruso, Giovanni Esposito, Gaetano Raiola.
       Introduction: In Italy, legislation in Exercise and sports sciences (ESS) had significant progress, particularly in physical and sport education, as well as sport pedagogy for compulsory teaching of Physical education by master's degree' specialist teachers, for the new profession of kinesiologist and, first the reform of Italian Constitution about social and educational value of movement and sport. The aim of this study was to measure the specific scientific output in ESS and its impact on the scientific community.
    Methods: Data on global scientific production related to the keywords "Physical education," "Sport education," and "Sport pedagogy" were extracted from the Scopus database, including total citations and h-index. Trends among Italian researchers were also examined. Data on the overall scientific output and specific trends of Italian researchers were extracted, along with total citations and h-index. The trends of total and relative metrics (citations and h-index) for the period 2020-2023 were evaluated using Spearman's correlation.
    Results: Analysis of global scientific production on Scopus revealed 31 ESS faculty members (7 full professors, 15 associate professors and 9 researchers) for "Sport Education" keyword, 11 ESS faculty members (2 full professors, 5 associate professors, and 4 researcher) for "Sport Pedagogy," and 18 ESS faculty members (7 full professors, 7 associate professors and 4 researcher) for "Physical Education." Less than half of these researchers are directly framed with ESS. However, despite this minority representation, significant positive correlations emerged between total citations and total H-index for the period 2020-2023 (rs = 0.83), relative citations and relative H-index (rs = 0.61), relative citation and total H-index (rs = 0.32).
    Conclusions: The positive correlation found between relative citations and the total h-index indicated these scholars had a greater impact with studies relevant to the identified keywords compared to other general topics. The analysis also highlighted the lack of international impact of Italian research in the educational and didactic aspect of ESS, particularly for "Physical Education."
    Keywords:  Scopus; citations; scientific disciplines; scientific production; sports science
    DOI:  https://doi.org/10.3389/frma.2025.1478317
  71. Cureus. 2025 Apr;17(4): e82688
    Bibliometric Analysis of Small-Cell Lung Cancer in Geriatric Populations.
    Dyuthi Nallavolu, Sydney N Vaughn, Latha Ganti.
      This study aimed to analyze the literature published about small-cell lung cancer (SCLC) in geriatric populations on a global scale from 1979 to 2023. This bibliometric analysis was performed by gathering data from the Web of Science Core Data Collection, using keywords such as small-cell lung cancer, SCLC, extensive-stage SCLC (ES-SCLC), and oat cell cancer. The search was further refined to target an older adult population by incorporating keywords such as 65+ years of age, geriatric patients, and baby boomers. These articles were then analyzed using VOSviewer. Maps were generated using sorting methods, focusing specifically on organizations, countries, and keywords. More than 7,710 articles spanning from 1979 to 2023 were analyzed. The United States, the People's Republic of China, and Japan produced the most publications on small-cell lung cancer in geriatric patients. When analyzing keywords used in studies on small-cell lung cancer in geriatric patients, many were related to the treatment and therapy of the disease. This bibliometric analysis shows that as time progresses, the focus of the United States, the People's Republic of China, and Japan is to increase research on therapeutics and treatments to help remedy small-cell lung cancer in order to decrease fatal lung cancer diagnoses in geriatric patients. If these countries continue their research efforts as before, more advancements in treatment can be made to ultimately find a cure for small-cell lung cancer, particularly impacting geriatric populations.
    Keywords:  bibliometric analysis; chemotherapy; oncology; pulmonology research; small cell lung cancer (sclc)
    DOI:  https://doi.org/10.7759/cureus.82688
  72. Innov Pharm. 2024 ;15(4):
    Scopus Indexing Delays of Articles Published in Major Pharmacy Practice Journals.
    Samuel O Adeosun.
      Background: Authors of bibliometric studies often wait for an arbitrarily prolonged period to allow for complete indexing of documents in the Scopus database after the end of the period to be studied (period-of-interest), thus negatively affecting recency (interval between publication date the date of the latest data reported) in bibliometric studies. Objective: The goal of this study is to determine the indexing delays in Scopus following online publication, to provide evidence-based recommendations for when data collection in Scopus should start after the end of the period-of-interest. Methods: Scopus indexing dates were prospectively collected for documents published in 2022 in 7 major pharmacy practice journals (aim 1). A time-to-event analysis was done on all documents published online from August to October 2022 (aim 2). Indexing delays and Kaplan-Meier curves of indexing delays were also compared between Scopus and PubMed using Wilcoxon signed-rank and Log-Rank tests, respectively. Results: All 7 journals (843 documents) and 4 journals (212 documents) were included in aims 1 and 2, respectively. Indexing delay was significantly longer in Scopus versus PubMed (median = 36 vs. 3 days). The Kaplan-Meier curves were also significantly different; with median survival time of indexing in Scopus and PubMed being 4 and 2 weeks, respectively. Notably, 91% of the subset studied have been indexed in Scopus (versus 97% in PubMed) by 10 weeks after online publication. Conclusion: Scopus indexing delays do not support the arbitrarily prolonged wait for bibliometric data to accumulate. A 10-week wait time provides a reasonable balance between the recency and completeness of published data. This evidence-based recommendation would improve recency without sacrificing data completeness in bibliometric studies.
    Keywords:  Bibliometric; Indexing delay; Pharmacy practice; PubMed; Scopus
    DOI:  https://doi.org/10.24926/iip.v15i4.6322
  73. Front Med (Lausanne). 2025 ;12 1547850
    Bibliometric analysis of tumor marker application in gastric cancer diagnosis from 2019 to 2024.
    Zhanat Komekbay, Reza Shirazi, Gulnaz Yessultanova, Alisher Garifollin, Anar Tulyayeva, Nurgul Kereyeva, Saule Akhmetova, Abdiraman Kaliev.
      Gastric cancer remains a significant global health challenge, ranking fifth worldwide in both incidence and mortality worldwide. Early detection and accurate prognosis are crucial for effective management, yet current diagnostic methods, including tumor markers, often exhibit less sensitivity. This bibliometric analysis investigates trends and key contributions in research on tumor markers for gastric cancer diagnosis from 2019 to 2024. Using Scopus and Web of Science databases, 2,940 articles were analyzed to assess publication trends, prominent authors, institutions, and emerging research themes. Results highlight East Asia, particularly institutions like Fudan University and Nanjing Medical University, as a hub for groundbreaking research. The study identifies key tumor markers and advances in molecular diagnostics, with emphasis on personalized medicine and early detection strategies. Visualization of global collaborations reveals extensive networks driving innovation in this field. While this analysis underscores progress in gastric cancer biomarker research, it also identifies limitations, including language bias and a narrow temporal scope. Future research should prioritize novel biomarkers, integrate advanced technologies like AI, and enhance international cooperation to further improve outcomes for gastric cancer patients.
    Keywords:  diagnosis; gastric cancer; immunohistochemistry; prognosis; tumor marker
    DOI:  https://doi.org/10.3389/fmed.2025.1547850
  74. Front Immunol. 2025 ;16 1613886
    Editorial: Neutrophil extracellular traps (NETs) triggered by helminths and protozoan parasites.
    Rafael M Mariante, Tamara Muñoz-Caro, Elvira M Saraiva.
      
    Keywords:  Besnoitia besnoiti; Calicophoron daubneyi; Entamoeba histolytica; NETs; bibliometric analysis; helminths; neutrophils; protozoa
    DOI:  https://doi.org/10.3389/fimmu.2025.1613886
  75. Int J Surg. 2025 May 23.
    Bibliometric insights into breast cancer organoid chips: trends & emerging areas.
    Yuanyuan Tian, Hui Chang, Meiying Cheng, Jian Jin, Xiaolong Ye, Xin Zhao.
      Breast cancer organoid microarray technology, as an emerging research tool, has been used to construct breast cancer organoid models with physiological functions in vitro by simulating the tumor microenvironment, providing powerful support for in-depth understanding of breast cancer pathogenesis, drug screening, personalized treatment, and prognosis assessment. The aim of this study is to delve into the research hotspots and prospective directions of breast cancer organoid microarrays, and to better understand the opportunities in the research hotspot areas. The Web of Science Core Collection database was used to search for articles published on the combination of organoid and microarray research in breast cancer, using bibliometric methods to analyze authors, research institutions, countries, journals, references and visualized by CiteSpace and VOSviewer. A total of 151 documents were included in this study, revealing a steady annual increase in publications with country China publishing the most articles with the highest citation (1667). Fudan University, Sun Yat-Sen University and China Medical University contributed the most research with 5 articles published. Nanyang Technological University and the Massachusetts Institute of Technology are the institutions with the highest connection strength, indicating that their cooperation and communication in this field play an important role. Over the past decade, the focus of breast cancer research has shifted from the optimization and standardization of organoid culture models to the simulation of the tumor microenvironment and the establishment of disease models. Subsequent research trends include improving the pathological representativeness of the models, drug screening and personalized therapy. This study provides an objective and comprehensive analytical perspective on the research prospects of breast cancer organoids, pointing out the way for future research.
    Keywords:  bibliometrics; breast cancer organoids; citeSpace; development trend; organoid chip; vOSviewer
    DOI:  https://doi.org/10.1097/JS9.0000000000002560
  76. Int J Surg. 2025 May 20.
    A commentary: "Global trends in surgically based treatment of anal fistula in Crohn's disease: a bibliometric and visualization analysis".
    Xiangcheng Hu, Lingling Ren, Shuyuan Zhu, Fangling Chen, Haiping Shen, Chengyong Qian, Guanglan Chen.
      
    DOI:  https://doi.org/10.1097/JS9.0000000000002564
  77. J Neurol Surg A Cent Eur Neurosurg. 2025 Mar;86(S 01): S23-S26
    Over 70 Years of Neurosurgical Research: A Comparison of the Publication Performance of Two Leading Journals: "Acta Neurochirurgica" and "Zentralblatt für Neurochirurgie".
    Daniel Dubinski, Uwe Hans Wiese.
      The aim of this study is to compare the publication performance of two leading neurosurgical journals, "Acta Neurochirurgica" and "Zentralblatt für Neurochirurgie," over a period of over 70 years. Trends in the number of publications as well as the thematic development of neurosurgical research will be analyzed. For this study, the abstracts of publications from the years 1951 and 2023 in the two leading neurosurgical journals "Acta Neurochirurgica" and "Zentralblatt für Neurochirurgie" were analyzed by the authors. For the sake of clarity, a thematic categorization into thematic blocks has been made. The publication performance in the analyzed journals has significantly increased from one volume with 21 articles for Acta Neurochirurgica in 1951 to 12 volumes in with 506 articles in 2023. A total of one volume with 32 articles was recorded for Zentralblatt für Neurochirurgie in 1951 versus a total of 6 volumes with 90 articles in 2023. Furthermore, new research areas represented include epilepsy surgery, technological innovations such as robotic surgery and virtual reality, hydrocephalus, advancements in neurosurgical education, deep brain stimulation as well as historical and biographical topics. Overall, the results illustrate a significant enhancement in the publication output and thematic richness of neurosurgical research in over more than 70 years. This development underscores the dynamic and evolving nature of the field, driven by continuous scientific and technological advancements. Our comparison highlights the significant role of the journals "Acta Neurochirurgica" and "Zentralblatt für Neurochirurgie" in disseminating knowledge and promoting scientific progress in neurosurgery in Germany.
    DOI:  https://doi.org/10.1055/a-2558-3320
  78. Int J Surg. 2025 May 20.
    Twenty-year panoramic review of stem cells research in kidney diseases (2005-2025): a bibliometric and clinical trial-based exploration.
    Jiayou Liu, Jiyuan Hu, Xue Gao, Hongfang Liu.
      Over the past two decades, a systematic elucidation of the overall trajectory and clinical translation of stem cell research in kidney diseases has been lacking. To address this gap, we conducted a bibliometric analysis and clinical trial search focusing on the period from 2005 to 2025, thereby mapping the global landscape of stem cell research in kidney diseases. Our results indicate a growing body of literature, accompanied by extensive international collaborations, with the United States and China leading in research output. In terms of research themes, mesenchymal stem cells continue to garner sustained attention for their reparative applications. Over the past decade, there has been a marked increase in studies on exosomes, extracellular vesicles, and kidney organoids. Nevertheless, clinical translation remains relatively delayed, suggesting that laboratory discoveries require additional time to reach bedside applications. This study provides a global perspective grounded in empirical data, helping to clarify critical frontiers and challenges.
    Keywords:  bibliometrics; frontiers; kidney diseases; stem cells
    DOI:  https://doi.org/10.1097/JS9.0000000000002479
  79. PLoS One. 2025 ;20(5): e0323364
    Closing the publishing gender gap in economics and political science: Does a critical mass matter?
    Daniel Stockemer, Gabriela Galassi, Engi Abou-El-Kheir.
      Using novel data on publications and citations by researchers in economics and political science in top 50 universities globally, we analyze the relationship between female representation and the gender gap in research output and impact. Using the concepts of substantive representation and critical mass, we expect that the average female researcher in departments with more women publishes more and receives more citations than the average female researcher in universities with a lower share of female faculty. Comparing women's publication and citation performance for the top 50 universities across the globe relative to men's, we find support for these expectations. We find that female researchers' performance matches that of their male counterparts in balanced departments, which are more common in political science. In contrast, the link between female performance and representation is weaker in departments with little gender balance, which are more typical in economics. These findings highlight the importance of reaching a critical mass of female representation to close gender gaps in research output and impact.
    DOI:  https://doi.org/10.1371/journal.pone.0323364
  80. Mechanobiol Med. 2025 Jun;3(2): 100127
    Multidimensional excavation of the current status and trends of mechanobiology in cardiovascular homeostasis and remodeling within 20 years.
    Wei Liao, Yuxi Huang, Xiangxiu Wang, Ziqiu Hu, Chuanrong Zhao, Guixue Wang.
      Mechanobiology is essential for cardiovascular structure and function and regulates the normal physiological and pathological processes of the cardiovascular system. Cells in the cardiovascular system are extremely sensitive to their mechanical environment, and once mechanical stimulation is abnormal, the homeostasis mechanism is damaged or lost, leading to the occurrence of pathological remodeling diseases. In the past 20 years, many articles concerning the mechanobiology of cardiovascular homeostasis and remodeling have been published. To better understand the current development status, research hotspots and future development trends in the field, this paper uses CiteSpace software for bibliometric analysis, quantifies and visualizes the articles published in this field in the past 20 years, and reviews the research hotspots and emerging trends. The regulatory effects of mechanical stimulation on the biological behavior of endothelial cells, smooth muscle cells and the extracellular matrix, as well as the mechanical-related remodeling mechanism in heart failure, have always been research hotspots in this field. This paper reviews the research advances of these research hotspots in detail. This paper also introduces the research status of emerging hotspots, such as those related to cardiac fibrosis, homeostasis, mechanosensitive transcription factors and mechanosensitive ion channels. We hope to provide a systematic framework and new ideas for follow-up research on mechanobiology in the field of cardiovascular homeostasis and remodeling and promote the discovery of more therapeutic targets and novel markers of mechanobiology in the cardiovascular system.
    Keywords:  Bibliometrics; Cardiovascular homeostasis; Cardiovascular remodeling; Mechanobiology; Research status; Research trends
    DOI:  https://doi.org/10.1016/j.mbm.2025.100127
  81. ANZ J Surg. 2025 May 19.
    Outcomes of Foundational Learning in Research Methods Following Primary Medical Qualification on Surgical Research: A Retrospective Review.
    Meet Patel, David Sun, Maya Jane Starr, Dhaval Solanki, Jeet Upadhyay, Dominic J A Edwards, Arjun Raju, Thomas Maouris, Alexander Lombardo, Daphne Wang, Karamveer Nagi, Nazim Bhimani, Anthony R Glover.
       INTRODUCTION: Limited knowledge exists on how post-graduate surgical coursework programs impact surgical research outputs in Australia. This study evaluated the impact of university-based teaching in research methods and supervisor characteristics on research quality and short-term research output for students undertaking the Master of Surgery (MS) post-graduate coursework degree within Australia.
    METHODS: A retrospective cohort analysis of students enrolled in the dissertation for The University of Sydney MS program between 2010 and 2020. Grades for the dissertation and research subjects were extracted from the central university analytics. PubMed and Web of Science were used to determine if the dissertation was published and identify other publications by the students. A Google search was completed to identify supervisor characteristics. Statistical analysis involved logistic regression, multiple linear regression and negative binomial regression.
    RESULTS: Three hundred and seventy-nine students were included in this study. Fifty-three percent of the students had an associated publication from their dissertation at a median of 18 months post-enrolment and a median journal impact factor of 2.19. Students averaged 2.1 additional publications (range 0-30) 2 years post-dissertation completion. Students with a distinction/high distinction grade in the dissertation subject or ≥ three journal publications prior were significantly more likely to publish their dissertation (OR 2.26, 95% CI = 1.42-3.61, p < 0.001; OR 3.35, 95% CI = 1.90-5.92, p < 0.001 respectively). Students who received a distinction/high distinction in the research methods subject had 64% more first-author publications within 2 years of finishing the dissertation (95% CI = 1.20-2.23, p = 0.002).
    CONCLUSION: Engagement in structured teaching in research methods and prior research experience significantly improve short-term research output amongst early surgical researchers.
    Keywords:  education; outcomes; postgraduate; research; surgery
    DOI:  https://doi.org/10.1111/ans.70184
  82. Int J Surg. 2025 May 20.
    Comments on "Peripheral nerve blocks for hip fracture surgeries: a bibliometric and visual analysis".
    Xinxing Fei, Jiayi Song, Yue Hu.
      
    DOI:  https://doi.org/10.1097/JS9.0000000000002542
  83. Nat Comput Sci. 2025 May 20.
    The critical role of persistent disruption in advancing science.
    Nan Deng, Xifeng Gu, Ying Fan, Shlomo Havlin, An Zeng.
      Disruptive innovation is an important feature of scientific research. However, increasing evidence in recent years shows that highly disruptive papers are not necessarily milestone works in science and may even receive very few citations. To understand the mechanisms leading to such phenomena, we develop a link disruption metric that quantifies the disruptiveness of each citation link. This metric allows us to investigate disruption at both the reference and citation levels, enabling the development of a two-dimensional framework to evaluate the persistence of disruption caused by a given paper. Surprisingly, we find that papers with high reference disruption can have high citation disruption, meaning that a paper that disrupts previous papers may itself be further disrupted by its later citing papers. We find that persistently disruptive papers (disruptive papers that are not disrupted by citing papers) are more likely to be recognized as award-winning papers and receive high numbers of citations. Finally, we find that papers of larger teams and papers in recent years, though found to have weaker disruption, are more likely to have stronger persistent disruption once they disrupt previous papers.
    DOI:  https://doi.org/10.1038/s43588-025-00808-7
  84. Comput Biol Med. 2025 May 17. pii: S0010-4825(25)00714-0. [Epub ahead of print]192(Pt B): 110363
    LITERAS: Biomedical literature review and citation retrieval agents.
    Alon Gorenshtein, Kamel Shihada, Moran Sorka, Dvir Aran, Shahar Shelly.
       BACKGROUND: Existing tools for reference retrieval using large language models (LLMs) frequently generate inaccurate, gray literature or fabricated citations, leading to poor accuracy. In this study, we aim to address this gap by developing a highly accurate reference retrieval system focusing on the precision and reliability of citations across five medical fields.
    METHODS: We developed open-source multi-AI agent, literature review, and citation retrieval agents (LITERAS) designed to generate literature review drafts with accurate and confirmable citations. LITERAS integrates a search through the largest biomedical literature database (MEDLINE) via PubMed's application programming interface and bidirectional inter-agent communication to enhance citation accuracy and reliability. To evaluate its performance, we compared LITERAS to state-of-the-art LLMs, Sonar and Sonar-Pro by Perplexity AI. The evaluation covered five distinct medical disciplines Oncology, Cardiology, Rheumatology, Psychiatry, and Infectious Diseases/Public Health, focusing on the credibility, precision, and confirmation of citations, as well as the overall quality of the referenced sources.
    RESULTS: LITERAS achieved near-perfect citation accuracy (i.e., whether references match real publications) at 99.82 %, statistically indistinguishable from Sonar (100.00 %, p = 0.065) and Sonar-Pro (99.93 %, p = 0.074). When focusing on referencing accuracy (the consistency between in-text citation details and metadata), LITERAS (96.81 %) significantly outperformed Sonar (89.07 %, p < 0.001) and matched Sonar-Pro (96.33 %, p = 0.139). Notably, LITERAS exclusively relied on Q1-Q2, peer-reviewed journals (0 % nonacademic content), whereas Sonar contained 35.60 % (p < 0.01) nonacademic sources, and Sonar-Pro used 6.47 % (p < 0.001). However, Sonar-Pro cited higher-impact journals than LITERAS (median impact factor (IF) = 14.70 vs LITERAS 3.70, p < 0.001). LITERAS's multi-agent loop (2.2 ± 1.34 iterations per query) minimized hallucinations and consistently prioritized recent articles (IQR = 2023-2024). The field-specific analysis demonstrated the oncology field with the largest IF discrepancies (Sonar-Pro 42.1 vs LITERAS 4.3, p < 0.001), reflecting Sonar-Pro's preference for major consortium guidelines and high-impact meta-analyses.
    CONCLUSION: LITERAS demonstrated significantly higher retrieval of recent academic journal articles and generating longer summary report compared to academic search LLMs approaches in literature review tasks. This work provides insights into improving the reliability of AI-assisted literature review systems.
    Keywords:  Agents; Artificial intelligence; Citations; Large language models; Literature review; Multi AI agents
    DOI:  https://doi.org/10.1016/j.compbiomed.2025.110363
  85. Health Res Policy Syst. 2025 May 22. 23(1): 65
    The positioning of policy documents in the field of health policy and systems research.
    Sama'a Almubarak.
       BACKGROUND: In realization of the importance of health policy, several scholars have examined health policies, contributing to the development of the field of health policy and systems research (HPSR). A growing body of literature within HPSR systematically analyses published articles in journals to examine how specific topics are dealt with in HPSR journals. The focus has extensively been on how research shapes policies and transfer of research to policy and practice. The present study takes a new approach in thinking about policy documents by exploring how policy documents are positioned in HPSR publications. In other words, the study answers the question of how policy documents are positioned in HPSR journal articles.
    METHODS: The study examined how policy documents were positioned in selected health policy journal articles. It analysed articles in Q1 journals indexed in Scopus under the journal subject health policy and published in 2022. A total of 52 articles were included in the full analysis. A data collection tool was created to tabulate extracted data which included data about journals, articles, and policy and methodological descriptions. Data were interpreted and analysed using descriptive statistics.
    RESULTS: Original research articles represented the majority of the analysed articles (72%). Multiple authorship was most common (63%), with authors from Western countries contributing the most to the publications. Analysed policies had a wide variety of foci and were mainly national-level policies (63%). Most of the articles included more than one policy for analysis (86%). Document analysis of policy documents was the only source of data in 33% of the articles. In addition, 27% of the articles lacked depth or details on how document analysis was conducted. The majority of the articles were aligned with policymaking as one phase of the policy process (31%).
    CONCLUSIONS: The study reflects a primary effort to examine how policy documents are positioned in HPSR articles. The study's findings contribute to the extant literature on the limited use of document analysis in HPSR. It further extends the research policy gap by understanding policy documents as a primary data source for researchers with a clear lack of its consideration for policy implementation or evaluation. The study's findings introduce implications and provide recommendations for research, policy and practice.
    Keywords:  Health policy; Health policy and systems research; Journal articles; Policy documents
    DOI:  https://doi.org/10.1186/s12961-025-01344-6
  86. J Food Sci. 2025 May;90(5): e70271
    Tetramethylpyrazine in Vinegar: A Bibliometric Analysis and Synthetic Mechanism.
    Linfeng Xie, Yiwen Xiao, Ya Wang, Jiantao Liu, Boliang Gao, Bin Liu, Du Zhu.
      Vinegar is widely recognized for its distinctive flavor, nutritional value, and numerous health benefits, which are particularly attributed to the presence of tetramethylpyrazine (TMP). TMP not only contributes to the aroma of vinegar but also exhibits significant anti-inflammatory, antioxidant, and cardioprotective effects. Despite the substantial body of research on this compound, the available information regarding TMP in vinegar remains fragmented, highlighting the need for a comprehensive review. This article conducts a bibliometric analysis of publications on TMP in vinegar indexed in the Scopus database between 2010 and September 2024. The review explores the production mechanisms, modes of action, and detection methods of TMP in vinegar, in relation to the vinegar fermentation process. It provides an in-depth analysis of the key stages in TMP production, including fermentation conditions, strain selection, and post-fermentation treatments, as well as optimization strategies. Additionally, it examines the main genes involved in TMP biosynthesis and their associated regulatory networks. The review integrates recent advances in this field and outlines future research directions, with the ultimate goal of offering theoretical insights and technical guidance for the advancement of vinegar production and the development of related functional foods.
    Keywords:  formation mechanism; health flavor factors; testing method; tetramethylpyrazine; vinegar
    DOI:  https://doi.org/10.1111/1750-3841.70271
  87. Int J Prosthodont. 2025 May 19. 0(0): 1-31
    Who are the Hybrid Ceramics? Bibliometric Review.
    Tatiana Roman, Kharouf Naji, Matei Dan Calinescu, Cournault Bérangère, Etienne Olivier.
       PURPOSE: An abundance of novel materials has been added to the dental prosthodontics market. Among these materials, a new category - the 'hybrid ceramic' seems to have gained researcher's interest. It is yet unclear which biomaterials should be labelled as 'hybrid ceramics'. This bibliometric and narrative review aims to find which biomaterials are referred to as 'hybrid ceramic' and describe their principal properties, when available.
    MATERIALS AND METHODS: Two reviewers executed a literature search up to the 15th June 2024 in three electronic databases PubMED, Web of Science and Scopus. All commercial names of biomaterials labelled as "hybrid ceramic" were retrieved, if pertinent to the dental prosthesis. Articles referring to hybrid ceramic abutments were excluded.
    RESULTS: 771 studies mentioning a 'hybrid ceramic' have been identified and 226 have been selected for this bibliometric study. 25 biomaterials have been identified labelled a 'hybrid ceramics,' including 4 experimental biomaterials, 2 indirect lutable composites, 3 glass ceramics, 2 printable permanent crown resins and 14 resin based CAD/CAM blocks. Their mechanical, optical and biological properties have been described, when available.
    CONCLUSIONS: Hybrid ceramics are popular in the research field yet are often mislabelled. A new, detailed classification is needed.
    DOI:  https://doi.org/10.11607/ijp.9210
  88. PLoS One. 2025 ;20(5): e0322943
    Membership in team science institute enhances diversity of researchers' collaboration networks.
    William C Barley, Ly Dinh, Lauren P Johnson, Brian F Allan.
      Interdisciplinary scientific teams are subject to a complex constellation of potential benefits, such as enabling innovation, and challenges, such as increased conflict and failure. Given these tensions, scholars and practitioners are increasingly interested in the role that organizational policies and resources can play in potentially mitigating the challenges faced on interdisciplinary teams. We report results from quantitative case study of a research institute dedicated to providing resources to enable interdisciplinary scientific teams, to examine how joining an organization with resources devoted to interdisciplinarity affected researchers' collaborations. We adopt bibliometric network techniques to explore the productivity and diversity of scientists' collaborations before and after joining the institute. Generalized linear mixed-effect modeling shows a significant increase for researchers in their number of papers and co-authors after joining the institute. Comparison to a matched pair control group indicates researchers who joined the institute experienced a significantly greater increase in their diversity of co-authors, and no relative decrease in the number of papers produced, despite challenges inherent to interdisciplinary collaboration. These findings suggest institutional resources can operate to broaden collaboration diversity without harming researcher productivity, which has important implications for team science and science policy.
    DOI:  https://doi.org/10.1371/journal.pone.0322943
  89. J Am Acad Dermatol. 2025 May 21. pii: S0190-9622(25)02185-1. [Epub ahead of print]
    Factors Associated with Academic Promotion Among US Academic Dermatologists.
    G Ege Eskibozkurt, Emma Beagles, Li-Chi Chen, Alexa B Kimball, Allen F Shih.
      
    Keywords:  Academic Medicine; Academic Promotion; Career Advancement; Dermatology Faculty; Factors Associated with Promotion; Research Productivity
    DOI:  https://doi.org/10.1016/j.jaad.2025.05.1402
  90. Adv Physiol Educ. 2025 May 19.
    Bibliometric guides to early physical exercise, education, and rehabilitation (PEER) research on girls and women.
    James L Nuzzo.
      Today, the historical representation of women as participants in exercise science research is frequently discussed. Often omitted from these discussions is women's participation in early research in fields that are historically linked to exercise science (e.g., physical education, physical therapy). Because much interest in women's health was expressed in papers published in these other fields, omission of this content from contemporary discussions about women's research representation gives an impression that early researchers, many of whom were female physical educators and therapists, were disinterested in women's health, including the menstrual cycle. To address this impression and expand historical knowledge in the field, I created two bibliometric lists of relevant historical content published in physical exercise, education, and rehabilitation (PEER) journals before 1980. The first list is comprised of 95 papers that included 306 photographs of girls and women participating in PEER research between 1907-1979. These papers were discovered via searches of personal files and the complete digital archives of Journal of Applied Physiology (1948-1979), Medicine and Science in Sports (1969-1979), and Research Quarterly (1930-1979). Photographs often showed girls and women being assessed on muscle strength, motor skill learning, body composition, and posture. The second list is comprised of 77 papers (1876-1979) that included data or commentary on the menstrual cycle or menstrual symptoms (e.g., dysmenorrhea) within PEER contexts. Brief descriptions of the papers and photographs are presented. Educators and researchers can use these bibliometric lists to enrich future lectures and writings regarding the history of women's early participation in PEER research.
    Keywords:  gender; history; menstrual cycle; sex; women’s health
    DOI:  https://doi.org/10.1152/advan.00196.2024
  91. Genes Environ. 2025 May 21. 47(1): 10
    Genes and Environment: reflections on its journey, past and future.
    Takashi Yagi.
      This article outlines the history and development of Genes and Environment, the official journal of the Japanese Environmental Mutagen and Genome Society (JEMS). In the 1970s, there was growing concern about the mutagenicity of chemical substances, leading to the establishment of JEMS. The society began publishing its journal, Environmental Mutagen Research, and renamed Genes and Environment in 2006 to focus on gene-environment interactions and promote international collaboration. The journal transitioned to free-access and started publishing in English to expand its reach globally.From 2012, the journal partnered with BioMed Central (BMC) to become an open-access publication, leading to its inclusion in Scopus, PubMed, and SCIE, and an improvement in its CiteScore and Impact Factor. JEMS also sought funding from Japan's Grants-in-Aid for Scientific Research (KAKENHI) to support international dissemination of research.Despite progress, challenges remain, such as limited submissions from certain regions and a need for greater global recognition. To further internationalize JEMS, efforts are being made to elevate the quality of research and broaden membership diversity, with a focus on making JEMS' activities and publications more accessible to the global scientific community.
    Keywords:  Internationalization of JEMS and journal; JEMS official journal; Journal development; Research dissemination
    DOI:  https://doi.org/10.1186/s41021-025-00333-z
  92. Int J Biol Macromol. 2025 May 21. pii: S0141-8130(25)04990-6. [Epub ahead of print]315(Pt 1): 144438
    Global trends and perspectives in nanochitin research: A comprehensive review of types, properties, applications, and scientometric analysis.
    Soibam Ngasotter, Maibam Malemngamba Meitei, K A Martin Xavier, Madhulika, Sanjeev Sharma, Soibam Khogen Singh, Jitender Kumar Jakhar, George Ninan.
      This review presents a detailed exploration of global trends and prospects in nanochitin research, focusing on its types, properties, applications, and scientometric analysis. Nanochitin, a nanoscale derivative of chitin, has gained significant interest due to its unique properties, such as mechanical strength, biocompatibility, and biodegradability. This paper explores various forms of nanochitin, including chitin nanocrystals (ChNCs)/chitin nanowhiskers (ChNWs) and chitin nanofibers (ChNFs), and their broad applicability across sectors such as food, electronics, agriculture, biomedicine, environment, and cosmetics. In food applications, nanochitin enhances preservation, acts as a functional additive, and promotes gut health. In electronics, its potential in flexible, biodegradable electronics is explored, while in agriculture, it functions as a growth promoter, antitranspirant, and pesticide. Biomedical applications include tissue engineering, wound healing, and drug delivery. The paper also explores its environmental uses in water purification and pollution control. In cosmetics, nanochitin offers biocompatibility, antibacterial, anti-inflammatory, moisturizing, and anti-aging properties, with recent advances highlighting its role as both a bioactive ingredient and delivery system in skincare. Additionally, the review incorporates scientometric analysis to identify key trends, influential contributors, and research gaps. The analysis reveals exponential publication growth since 1992, with China and Japan leading contributions and emerging hotspots in food packaging and Pickering emulsions. The prospects of nanochitin in advancing sustainable technologies and addressing global challenges are discussed, emphasizing the need for interdisciplinary research and development. This review aims to provide a foundational resource for researchers, guiding future innovations in nanochitin applications and commercialization.
    Keywords:  Bibliometric analysis; Chitin nanocrystals; Chitin nanofibers; Chitin nanoparticles; Chitin nanowhiskers
    DOI:  https://doi.org/10.1016/j.ijbiomac.2025.144438
  93. Ying Yong Sheng Tai Xue Bao. 2025 Mar 18. 36(3): 647-658
    Review on research methods of the surface urban heat island effect based on CNKI bibliometrics.
    Cen Chen, De-Zhuang Liang, Jun Yang, Dong-Rui Han, Zhi Qiao.
      The urban heat island (UHI) effect is an increasingly prominent local climate issue in the process of global urbanization, significantly impacting human settlement health and energy consumption. Based on the China National Knowledge Infrastructure (CNKI) database, we searched and analyzed Chinese journal articles on the surface urban heat island (SUHI) effect published during 1980 and 2024. Using CiteSpace software, we conducted a visual analysis of publication trends and keywords to systematically summarize the research advances. We reviewed and discussed the research hotspots, including data sources, identification methods, and evaluation indicators related to the surface urban heat island effect. We also proposed the shortages and challenges in current research, such as identification accuracy, mechanism analysis, and impact assessment. More works should be strengthened in future research, including optimizing multi-source data integration with cross-validation, innovating multi-scale dynamic evaluation methods, and enriching multi-dimension impact assessment systems. By reviewing the development process of surface urban heat island effect research in China, we hoped to provide theoretical support and technical guidance for future research, contributing to the deepening and practical application of the research.
    Keywords:  bibliometrics; evaluation indicator; identification method; remote sensing data; surface urban heat island effect
    DOI:  https://doi.org/10.13287/j.1001-9332.202503.029
  94. JB JS Open Access. 2025 Apr-Jun;10(2):pii: e24.00216. [Epub ahead of print]10(2):
    The Value of Research in the Orthopaedic Surgery Residency Applicant: A Pilot Survey of Orthopaedic Surgery Residency Program Directors.
    Ryan C White, Rithvik Vutukuri, Shreya M Saraf, Mia V Rumps, Mary K Mulcahey.
       Introduction: The role of research in the orthopaedic surgery residency application process has become increasingly important, particularly in the wake of the United States Medical Licensing Examination (USMLE) Step 1 examination transitioning to pass/fail. The purpose of this study was to determine the value that orthopaedic surgery residency program directors and other faculty place on various research elements included in residency applications.
    Methods: An anonymous cross-sectional survey was distributed to program directors and other faculty involved with the review of orthopaedic surgery residency applications within the Collaborative of Orthopaedic Education Research Group in February 2024. The survey asked questions related to the value placed on publication types, authorship position, dedicated research years, and the general importance of research.
    Results: Ten respondents, including 7 program directors, 2 assistant program directors, and 1 director of research, participated. Eight (80%) indicated that the number of publications is important, with 4 (40%) identifying a minimum number of publications of 2 to 3 to be considered competitive at their program. Respondents also identified the following components as important: journal impact factor (9; 90%), authorship position (5; 50%), and study type (7; 70%). Clinical research within orthopaedic surgery was most highly regarded (9; 90%), while case studies were deemed least valuable (9; 90%). Six respondents (60%) agreed that research is more important now that USMLE Step 1 is pass/fail.
    Conclusions: Since the transition of Step 1 to pass/fail, research has become an increasingly important part of an orthopaedic surgery resident's application. Residency programs value research productivity, particularly clinical research within orthopaedics. While the minimum number of publications varies, 2 to 3 are often considered competitive. Factors contributing to the perceived value of research include journal impact factor, authorship position, and study type. With this knowledge, applicants can align their research activities with the values of orthopaedic surgery residency programs.
    Level of Evidence: Level IV. See Instructions for Authors for a complete description of levels of evidence.
    DOI:  https://doi.org/10.2106/JBJS.OA.24.00216
  95. Front Cell Infect Microbiol. 2025 ;15 1568563
    Machine learning-based text mining for cutaneous myiasis and potential value of an accidental maggot therapy for complicated skin and soft tissue infection with sepsis.
    Zhiyuan Zhou, Chaoran Yu, Danhua Yao, Zhen Wang, Yuhua Huang, Pengfei Wang, Weimin Wang, Yousheng Li.
       Background: Cutaneous myiasis, one of the most frequently diagnosed myiasis types, is defined as skin or soft tissue on a living host infested by dipterous larvae (maggots). However, bibliometric analysis of this disease remains sparse. Machine learning techniques and updated publications provide an opportunity for such an investigation.
    Materials and methods: All the studies were retrieved from PubMed and were processed using R software in the bibliometric analysis and latent Dirichlet allocation (LDA) topic modeling. Furthermore, the clinical management of two diabetes patients with serious soft tissue infection-associated sepsis was analyzed.
    Results: A total of 211 results were retrieved and 50 topics relevant to cutaneous myiasis were determined by the LDA algorithm. The topics of uncommon fly species, nasal infestation, and physician discussion of cutaneous myiasis were consistently common over the last 20 years. Case report remains one of the key features in myiasis. Four major clusters were identified, i.e., case report related, disease type and development, travel in the tropics, and skin disease. To further delve into clinical practice, the clinical features of two patients with soft tissue infection-related sepsis were demonstrated, and a distinct beneficial role of myiasis was found. The levels of white blood cell, blood glucose, and C-reactive protein in the case with cutaneous myiasis were more stable than the other case without cutaneous myiasis but with sepsis shock.
    Conclusion: Maggot debridement therapy may be a promising treatment and beneficial for soft tissue infection-related sepsis. The model analysis of maggot therapy and its clinical advantages shows increasing research value and possible application in future clinical practice.
    Keywords:  bibliometric; cutaneous myiasis; diabetes; latent Dirichlet allocation; soft tissue infection
    DOI:  https://doi.org/10.3389/fcimb.2025.1568563
  96. Small Sci. 2025 May;5(5): 2400498
    Understanding the Mechanism of Cardiotoxicity Induced by Nanomaterials: A Comprehensive Review.
    Zaiyong Zheng, Shuang Zhu, Xiaobo Wang, Haoran Wu, Min Fu, Houxiang Hu, Zhanjun Gu, Chunxiang Zhang.
      Nanomaterials have been vastly used in daily life. However, owing to their unique properties, nanomaterials also show potential side effects. Among the various organs affected by nanomaterials, the circulatory system stands out as particularly vulnerable, drawing additional attention to its cardiac toxicity. To address the cardiovascular nanotoxicity and further promote the safe use of nanotechnology, a comprehensive review of the cardiotoxicity induced by nanomaterials is provided. The review begins by identifying the current research trends and hotspots in this field via a bibliometric analysis. Subsequently, based on the objectively obtained research hotspots, the mechanism of cardiovascular nanotoxicity, including exposure route, membrane injury, ion disturbance, oxidative stress, inflammation, and cell death, is reviewed and discussed. Finally, current strategies for the mitigation of nanotoxicity are also proposed. The objective of this review is to assist readers in understanding the mechanism of cardiotoxicity induced by nanomaterials and to facilitate their safe application for human health.
    Keywords:  bibliometric analyses; cardiovascular health; nanomaterials; nanotoxicities
    DOI:  https://doi.org/10.1002/smsc.202400498
  97. J Reconstr Microsurg. 2025 May 20.
    Career Paths After Microsurgery Fellowship: A 10-Year Analysis.
    Elaine Lin, Tara Pillai, Victoria N Yi, Ann Marie Flusche, Sakshi Chopra, Melissa Tran, Ash Patel, Kristen Rezak.
      Background Over the past 10 years, microsurgery fellowship programs and positions have increased by 50%, underscoring the need to understand graduate career paths and provide trainees context about future practice. This study analyzed who pursues microsurgery fellowships and factors associated with academic careers. Methods This cross-sectional analysis examined graduates from the past 10 years from fellowships recognized by the American Society of Reconstructive Microsurgery or graduates of international fellowships who completed residency in the United States. Demographic variables included gender, race, residency location, and Integrated vs. Independent plastic surgery residency. Bibliometric indices at the time of graduation and October 2024 were measured. Initial and current practice setting were categorized as academic (full-time faculty), "private affiliated" (involved in teaching but not full-time faculty), or private practice. Results Overall, 423 graduates were identified. The majority were male (62.9%) and White (63.4%). Most completed Integrated residency (72.6%). Five fellowships accounted for 48.0% of graduates: MD Anderson (80), Memorial Sloan Kettering (46), University of Pennsylvania (38), Stanford University (23), and The Buncke Clinic (16). After fellowship, 68.0% of graduates entered academia, and 63.2% of graduates are in academia currently out of 419 analyzed. Fellowship location was associated with initial academic practice (p=0.01), many graduates from International (80.0%), and Southern (78.4%) fellowships entering academia. Graduates in initial academic practice had higher median initial g-index (13 vs. 10, p=0.03) and median initial publications (15 vs. 11, p=0.02). Multiple logistic regression found initial publications and fellowship location to be best predictors of initial academic practice. Conclusion While most graduates pursue academia, a significant number enter private practice, indicating it is a viable option. Southern or International fellowships send more graduates into academia, but this is likely influenced by popular fellowships. Nuanced factors like personal preference, financial considerations, and networking likely play a significant role in career choices.
    DOI:  https://doi.org/10.1055/a-2616-4716
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