bims-evares Biomed News
on Evaluation of research
Issue of 2025–05–18
eighty papers selected by
Thomas Krichel, Open Library Society
  1. Bibliometric analysis of the GentleWave system: trends, collaborations, and research gaps.
  2. A bibliometric analysis of penile cancer research.
  3. From tradition to innovation: a bibliometric analysis of the evolution of periodontal plastic surgery.
  4. Mapping the global research landscape on psoriasis and the gut microbiota: visualization and bibliometric analysis.
  5. Research Trends and Knowledge Atlas of Radiotherapy-Related Cognitive Impairment: A Bibliometric Analysis.
  6. Global trends and research hotspots in autophagy and tumor drug resistance: a bibliometric analysis.
  7. Trends and Productivity in 3D Printing Technologies and Materials for Dental Research: A Bibliometric Analysis from 2013 to 2024.
  8. Frontiers and hotspot evolution in research on Alzheimer's disease and hypertension: a bibliometric analysis from 2004 to 2023.
  9. Research trends and hotspots of metabolites and inflammatory bowel disease: a bibliometric analysis.
  10. Current research status and hotspots of precancerous lesions of gastric cancer: a bibliometric analysis.
  11. Sustainable Practices in Anti-VEGF Therapy: A 15-Year Bibliometric Analysis of Ranibizumab for Age-Related Macular Degeneration.
  12. Data Privacy in Medical Informatics and Electronic Health Records: A Bibliometric Analysis.
  13. Research trends among new investigators at ISOQOL: a bibliometric analysis from 2019 to 2023.
  14. Academic influence of American College of Radiology Appropriateness Criteria: a citation analysis of thoracic and cardiac imaging guidelines.
  15. Global trends in radiography research: A bibliometric study of three key journals.
  16. Anterior cruciate ligament Reconstruction with Lateral Extra-Articular Augmentation: A Bibliometric Analysis of The Top 100 Cited Articles.
  17. Emerging trends and hotspots of tRNA-derived small RNAs in tumours: a bibliometric analysis via VOSviewer and CiteSpace.
  18. Maxillary Sinus Lift: A Bibliometric and Altmetric Analysis of the 100 Most Cited Articles.
  19. Global trends in cervical spondylosis research: a bibliometric analysis based on the Web of Science.
  20. Research Landscape on Adrenocortical Carcinoma Over Four Decades.
  21. Bibliometric insights into the top 100 most-cited annual studies on digital health in nursing education (2020-2024).
  22. Global trends in resistance studies of gemcitabine and pancreatic cancer: a bibliometric and visual analysis from 2010 to 2024.
  23. Fertility-sparing treatment for patients with endometrial cancer: a bibliometric analysis from 2000 to 2024.
  24. Bibliometric Analysis of Cross-Sectional Studies on Early Childhood Caries.
  25. Mapping the intersection of HIV and Alzheimer's disease: a bibliometric analysis of emerging research trends.
  26. Research on the developments of artificial intelligence in radiomics for oncology over the past decade: a bibliometric and visualized analysis.
  27. Advances in hydrogel research: a 25-year bibliometric overview.
  28. The Top 100 Cited Articles in Otology and Neurotology and Analysis of Female Authorship.
  29. Bibliometric and visual analysis of circadian rhythms in depression from 2004 to 2024.
  30. Global Publication Pattern in Ankle Arthroscopy: A Scopus®-Indexed Bibliometric Visualization Analysis.
  31. Trends and hotspots of design thinking in nursing research: A bibliometric analysis.
  32. Trends and hotspots on hymenoptera venom immunotherapy: a bibliometric and visualized analysis of research from 2014 to 2024.
  33. Teaching Spirituality in Nursing: Additional Evidence for Developing a Bibliometric Analysis.
  34. Research Advance of Causal Inference in Clinical Medicine: A Bibliometrics Analysis via Citespace.
  35. Bibliometric analysis of advances in polysaccharide pharmacology research: A review.
  36. Assessing academic impact through a bibliometrics analysis: Gastroesophageal reflux disease in the context of obesity treatment and bariatric surgery.
  37. Cardiac surgery-associated acute kidney injury: a decade of research trends and developments.
  38. Research trends and hotspots of single nucleotide polymorphisms in endometrial cancer: a bibliometric analysis.
  39. A bibliometric analysis of strabismus (from 2004 to 2023).
  40. Zebrafish and bioactive compounds: a bibliometric review.
  41. A Bibliometric Analysis of Microneedle-Mediated Drug Delivery: Trends, Hotspots, and Future Directions.
  42. Photodynamic therapy in esophageal cancer: trends, innovations, and future directions from a global perspective (1985-2024).
  43. A bibliometric analysis of metabolic dysfunction-associated steatotic liver disease in children from 2004 to 2024.
  44. A bibliometric analysis of electroencephalogram research in stroke: current trends and future directions.
  45. Scientific evolution of robotic surgery in urogenital diseases: bibliometric analysis.
  46. Trends and hotspots in pulmonary fibrosis biomarker research: a bibliometric analysis.
  47. Unveiling research hotspots: a bibliometric study on macrophages in musculoskeletal diseases.
  48. Leveraging artificial intelligence in disaster management: A comprehensive bibliometric review.
  49. Machine learning in ovarian cancer: a bibliometric and visual analysis from 2004 to 2024.
  50. A Bibliometric Review of Actigraphy-Based Sleep Research in Diabetes.
  51. The developments and emerging trends of Autonomic Nervous System Research in Arrhythmia: a bibliometric study from 2004 to 2024.
  52. Analysis of Article Processing Charges of Orthopaedic Journals in the United States.
  53. Research trends in microRNA profiling as a biomarker for lung adenocarcinoma via liquid biopsy: A bibliometric analysis.
  54. The Evolution of Machine Learning in Medicinal Chemistry: A Comprehensive Bibliometric Analysis.
  55. Shedding light on Brazil's contribution to photobiomodulation research in oral medicine: a bibliometric study.
  56. A decade of vertebrate palaeontology research: global taxa distribution, gender dynamics and evolving methodologies.
  57. Feasibility analysis and development trend of nanomaterials for the treatment of pancreatic cancer.
  58. International visualization analysis of research hotspots and development trends in the study of clinical decision support systems utilizing CiteSpace.
  59. Orthopaedic Authorship: Sex-Based Resident Publication Trends.
  60. Uneven Ground: Exploring the Impact of Geographical Region and Gender on Orthopaedic Surgery Resident Research Productivity.
  61. Trends in self-citation rates in high-impact neurology, neuroscience, and psychiatry journals.
  62. Editors' Selections from Relevant Scientific Publications.
  63. Endophytes of Zingiberaceae: distribution and bioactivity of their bioactive metabolites.
  64. Visual analysis of research progress and trend on hairy roots.
  65. Gender and racial diversity in leadership roles within academic surgery internationally: a retrospective cross-sectional study pre-COVID-19.
  66. Advances in complex thinking and neurotechnologies in education: a bibliometric analysis of research trends.
  67. Bibliometric analysis of brain-computer interface research in spinal cord injury: current landscape and future directions.
  68. Mapping the landscape of AI and ML in vaccine innovation: A bibliometric study.
  69. Forecasting emerging trends in transfusion medicine through complex network analysis of scholars' research.
  70. The Contribution of Turkish Hematology to Global Literature - A Comparative Analysis.
  71. Research transparency in articles published in orthodontic journals: is it clear?
  72. Audio-based digital biomarkers in diagnosing and managing respiratory diseases: a systematic review and bibliometric analysis.
  73. Increasing medical student participation in scholarly publications at a primary care-focused medical school.
  74. Sex and gender differences in cancer research and its application to clinical oncology and therapeutics.
  75. Business and entrepreneurship is declining as scholarly field: Empirical evidence.
  76. Forward Strides in Academic Plastic and Reconstructive Surgery Gender Representation: 2025 Update.
  77. Characterizing the Representation of Different Global Regions and National Income-Levels Amongst Invited Speakers and Committee Members at Major International Spine Surgery Conferences.
  78. An analysis of publication trends in Science Letters published in Anaesthesia.
  79. Knowledge circulation and the politics of citation: Referencing is not a neutral act.
  80. Impact of the First Swiss Conference on Prehospital Emergency Care and Trauma Research (SPECTRe) on Paramedics' Intention to Engage in Research: Cross-sectional Study.
  1. Restor Dent Endod. 2025 May 12.
    Bibliometric analysis of the GentleWave system: trends, collaborations, and research gaps.
    Raimundo Sales de Oliveira Neto, Thais de Moraes Souza, João Vitor Oliveira de Amorim, Thaine Oliveira Lima, Guilherme Ferreira da Silva, Rodrigo Ricci Vivan, Murilo Priori Alcalde, Marco Antonio Hungaro Duarte.
       Objectives: The study aimed to conduct a bibliometric analysis of the GentleWave system (Sonendo, Inc.).
    Methods: An electronic search was conducted in June 2024 using the Web of Science Collection database. Two reviewers independently screened publications, extracting data on authorship, publication details, study design, and citation metrics. Statistical analyses were performed in R to assess variable correlations, while the VOSviewer (Visualization of Similarities Viewer) software was used to map author and keyword networks.
    Results: The search yielded 47 records, with 32 studies included. Publications spanned 2014 to 2024. The Journal of Endodontics published the highest number of studies (n = 15), and the International Endodontic Journal had the highest impact factor (5.4). The University of British Columbia and Sonendo, Inc. were the most frequent affiliations. Among the 32 articles, 28 were in vitro studies, primarily focusing on microbiology (n = 9). A total of 95 authors were identified, with Haapasalo and Shen being the most cited (n = 229). The articles accumulated 495 citations, demonstrating a strong positive correlation between the number of studies and citation counts (r = 0.98).
    Conclusions: The analysis highlights a predominance of in vitro studies. Geographic concentration in the United States and Canada limits diversity, while the strong correlation between study numbers and citations suggests that increased publication volume enhances visibility.
    Keywords:  Bibliometrics; Endodontics; Multisonic; Root canal irrigants; Root canal therapy
    DOI:  https://doi.org/10.5395/rde.2025.50.e17
  2. Rev Int Androl. 2025 Mar;23(1): 38-49
    A bibliometric analysis of penile cancer research.
    Peng Zhao, Chengquan Ma.
       BACKGROUND: The purpose of this study is to investigate the collaboration among countries, institutions and authors in the field of penile cancer research, as well as to identify the current hot topics in this area.
    METHODS: Papers about penile cancer were retrieved from the Web of Science Core Collection (WoSCC). Bibliometric analyses were conducted using VOSviewer and CiteSpace to evaluate collaborations between different keywords, institutions, authors and countries in network maps.
    RESULTS: 2891 articles related to penile cancer were included. The number of publications were gradually increasing the from 1991 to 2023. Journal of Urology (196 papers) owned the highest number of publications and Journal of Urology was the most co-cited journal. Simon Horenblas was identified as the top productive author with 98 papers and received a large number of citations (5383 co-citations) over the past decades. The United States emerged as the leading publisher in this field with 932 papers published. Cooperation between countries and between institutions was observed. The hot topics included matters mainly related to squamous-cell carcinoma, cancer, penile cancer, erectile dysfunction, men, penis and lymphadenectomy.
    CONCLUSIONS: This study utilized visualization tools to create a knowledge map of penile cancer research which provides new insights into its time series development context, research hotspots, knowledge network structure and major scholars' contributions in this field.
    Keywords:  Bibliometric; Erectile dysfunction; Network maps; Penile neoplasms; Squamous-cell carcinoma
    DOI:  https://doi.org/10.22514/j.androl.2025.007
  3. J Periodontal Implant Sci. 2025 Feb 25.
    From tradition to innovation: a bibliometric analysis of the evolution of periodontal plastic surgery.
    Şeyma Çardakcı Bahar, Özlem Saraç Atagün, Seval Ceylan Şen, Gülbahar Ustaoğlu.
       PURPOSE: The aim of this study was to conduct a bibliometric analysis of the periodontal plastic surgery literature to identify trends, research gaps, and key themes within the field and to establish a perspective on documented research.
    METHODS: This bibliometric study examined research outputs on mucogingival surgery indexed in the Web of Science database from 1990 to 2023. The Science Mapping Analysis Tool (SciMAT) software was used to visualize and predict research trends on this topic.
    RESULTS: An analysis of publication distribution by year revealed a decline in the number of publications between 1984 and 1995, followed by an overall upward trend after 1996 despite occasional decreases. The United States contributed the most with 593 publications, and Wang HL (n=74) was the most prolific author. The most frequently used keyword was "gingival recession" (n=625). Overall, the publications received 44,859 citations, averaging 25.49 citations per publication.
    CONCLUSIONS: Researchers have made significant efforts to improve clinical practices and procedures in periodontal plastic surgery, resulting in an increase in studies over recent years. By analyzing thematic maps and clusters-using indicators such as frequency, citations, and centrality-researchers can identify the strengths, weaknesses, and gaps in current research.
    Keywords:  Bibliometrics; Connective tissue; Gingival recession; Journal impact factor; Periodontics
    DOI:  https://doi.org/10.5051/jpis.2404620231
  4. Front Cell Infect Microbiol. 2025 ;15 1531355
    Mapping the global research landscape on psoriasis and the gut microbiota: visualization and bibliometric analysis.
    Yue-Min Zou, Man-Ning Wu, Xiangnan Zhou, Yan-Ping Bai.
       Background: Psoriasis is a common chronic inflammatory skin disease with a complex pathogenesis. Recently, the role of gut microbiota in psoriasis has attracted increasing attention. A systematic bibliometric analysis of relevant literature is necessary to understand better the current state and development trends in this field.
    Materials and methods: The Web of Science Core Collection database was searched for literature indexed from 2004 to October 15, 2024. Bibliometric analysis was conducted using Bibliometrix, CiteSpace (version 6.3.R1), R 4.2.2 with the Bibliometrix package, Scimago Graphica 1.0.45, and VOSviewer (version 1.6.20.0) to visualize publication types, years, authors, countries, institutions, journal sources, references, and keywords.
    Results: The development of psoriasis and gut microbiota research can be divided into two phases: slow growth (2004-2014) and rapid development (2014-2024). Lidia Rudnicka is the most active and influential author. China produced the highest number of publications, followed by the United States, which had the highest number of citations per article. The International Journal of Molecular Sciences published the most articles. In contrast, articles in the Journal of Investigative Dermatology, British Journal of Dermatology, and Journal of Allergy and Clinical Immunology were cited over 1,000 times. Keyword and co-citation analyses identified evolving research hotspots. Early studies focused on the association between gut microbiota and comorbid inflammatory diseases. Recent research has delved into specific mechanisms, such as disruption of gut barrier function, short-chain fatty acid metabolism alterations, impaired regulatory T-cell function, and excessive activation of Th17 cells. These mechanisms highlight how gut dysbiosis exacerbates psoriasis patients' systemic inflammation and skin lesions.
    Conclusion: The field of psoriasis and gut microbiota research is developing rapidly despite uneven research distribution. This bibliometric evaluation assesses the current state of research and provides new perspectives for understanding the complex interactions between microbes and the host. Future efforts should strengthen international collaboration to deeply explore the mechanisms of gut microbiota's role in psoriasis, especially its potential applications in disease diagnosis and treatment.
    Keywords:  bibliometric analysis; gut microbiota; pathogenesis; psoriasis; research landscape
    DOI:  https://doi.org/10.3389/fcimb.2025.1531355
  5. Curr Neuropharmacol. 2025 May 09.
    Research Trends and Knowledge Atlas of Radiotherapy-Related Cognitive Impairment: A Bibliometric Analysis.
    Yaqian Tan, Qi Song, Siyuan Gao.
       BACKGROUND: Radiotherapy is one of the main therapeutic methods for tumors, and radiation- related cognitive impairment has attracted increasing attention. The purpose of this study was to explore the research prospects in the field of radiotherapy-associated cognitive decline through bibliometric analysis.
    METHODS: Literature on radiotherapy-related cognitive impairment published during 2004-2023 were extracted from the Web of Science Core Collection database. VOSviewer and R-bibliometrix were utilized to perform bibliometric analysis.
    RESULTS: A total of 8,365 publications were retrieved from the database. The United States emerged as the leading country in this research field, with St. Jude Children's Research Hospital identified as the most productive institution. Thomas E. Merchant was the most prolific author in this field, while Charles L. Limoli was the most frequently cited scholar. The research hotspots have gradually shifted from cognitive function and outcome measurement to the development of new therapy models.
    CONCLUSION: This study comprehensively examined the research hotspots and knowledge atlas of radiotherapy- related cognitive decline from a bibliometric perspective. Our results would assist scholars in identifying potential collaborators and significant literature in this field while also providing valuable guidance for future research directions.
    Keywords:  R-bibliometrix.; Radiotherapy; VOSviewer; bibliometric analysis; cognitive impairment; radiation; visualization
    DOI:  https://doi.org/10.2174/011570159X368986250415105149
  6. Discov Oncol. 2025 May 12. 16(1): 734
    Global trends and research hotspots in autophagy and tumor drug resistance: a bibliometric analysis.
    Long Zhao, Jiao Zeng, Junfeng Wen, Zhaoyang Li, Jianguo Xu, Jinxiang Wang, Xiaoping Tang, Lingmi Hou.
      Autophagy plays a crucial role in tumor drug resistance by enabling cancer cells to survive under stress conditions, including chemotherapy. It helps tumor cells maintain homeostasis, resist cell death, and contribute to therapy failure. This study analyzed the literature related to autophagy and tumor drug resistance based on the Web of Science Core Collection (WoSCC) database. The results revealed that there are 9284 relevant articles published to date, covering 103 countries and regions, with contributions from 5964 institutions and 37,240 researchers. The annual number of publications has steadily increased since 2004, especially after 2019, indicating the growing importance of autophagy in tumor drug resistance research. China leads globally in terms of publication output, accounting for nearly 50% of the total publications. Additionally, international collaboration and cross-country research have become increasingly prominent, particularly collaborations between China and countries like South Korea and Japan. Journal analysis showed that the International Journal of Molecular Sciences and Oncotarget are the most productive journals, while Autophagy stands out with a higher impact factor. Author, citation, and keyword analyses revealed research hotspots and future trends in the field of autophagy and tumor drug resistance, including chemotherapy resistance, cell death mechanisms, and immunotherapy. This study provides a systematic academic perspective for future research in the field of autophagy and tumor drug resistance and emphasizes the importance of strengthening international cooperation.
    Keywords:  Autophagy; Bibliometric analysis; Chemotherapy resistance; Tumor drug resistance
    DOI:  https://doi.org/10.1007/s12672-025-02379-5
  7. Int J Prosthodont. 2025 May 12. 0(0): 1-22
    Trends and Productivity in 3D Printing Technologies and Materials for Dental Research: A Bibliometric Analysis from 2013 to 2024.
    Omar Alageel.
       PURPOSE: Research on three-dimensional (3D) printing in dentistry has been widely studied, yet there is a gap in comprehensive bibliometric analysis focusing on materials and printing technologies used in this field. This study aims to analyze research trends from 2013 to 202 using a bibliometric approach, focusing on publication distribution, productivity, and trends in materials and 3D printing technologies in dentistry.
    MATERIAL AND METHODS: Data, including English language articles, were collected from the Web of Science Core Collection. Microsoft Excel and bibliometrix were used for quantitative analysis, while SPSS was employed for correlation and regression analysis.
    RESULTS: The analysis included 596 studies published in 161 journals. On average, each article received 13.47 citations, with 2,461 authors. International collaboration was significant, with 27.85% of studies involving co-authorship across countries. Publication volume has increased steadily, with an annual growth rate of 60.25%, peaking at 179 articles in 2023. The peak mean citation rate was 6.65 per article in 2019. Key authors and institutions from South Korea, Egypt, Switzerland, and Saudi Arabia. The USA led to article output and citations, followed by China and South Korea. This study identified key trends in material usage, highlighting the predominance of resin and zirconia, along with the significant use of DLP and SLA 3D printing technologies.
    CONCLUSIONS: 3D printing in dental research has grown rapidly, peaking in 2023. Notable advancements in resins and the development of DLP and SLA technologies underscore the transformative potential of 3D printing in dentistry.
    DOI:  https://doi.org/10.11607/ijp.9334
  8. Front Neurol. 2025 ;16 1514054
    Frontiers and hotspot evolution in research on Alzheimer's disease and hypertension: a bibliometric analysis from 2004 to 2023.
    Wenying Liu, Yaya Zhao, Yutong Rao, Zijing Wu, Yun Peng, Lianggeng Gong.
       Background: Alzheimer's disease (AD) is a neurodegenerative disease that imposes a heavy burden on patients and their families. Hypertension is an important risk factor for AD, but the specific mechanism of its impact is still unclear. This study thus aimed to analyze the relationship and trend changes between AD and hypertension through bibliometric methods.
    Methods: Literature on AD and hypertension was retrieved from the Web of Science Core Collection (WoSCC) database between 2004 and 2023. Data regarding countries, institutions, authors and journals were sourced from WoSCC. CiteSpace and VOSviewer were used for data visualization, including author collaboration, timelines view of references, reference bursts and overlay visualization maps of keywords. Excel 2018 software was used for the statistical analysis.
    Results: A total of 1,833 publications were ultimately included. From 2004 to 2023, the number of publications per year basically showed an increasing trend. The United States (United States) not only had the largest output of publications and the highest H-index but also had the seven highest frequencies of publication institutions. Kehoe, Patrick ranked first with the most articles among 9,330 authors. The journal with the most published articles was the Journal of Alzheimer's Disease. Reference analysis revealed a hotspot in the exploration of the pathophysiological association between AD and hypertension. Second, the treatment effects and potential risks of antihypertensive drugs (AHDs) on AD are also the focus of research. Researchers have carried out a series of studies ranging from basic research to clinical research on AHDs for the treatment of AD. Finally, personalized treatment strategies will also become one of the hotspots of future research. Controlling hypertension through lifestyle changes and medication interventions in AD patients is a promising strategy. The analysis of keywords revealed that "amyloid deposition," "preeclampsia," "Corona Virus Disease 2019 (COVID-19)" and "biomarkers" have been research hotspots in recent years.
    Conclusion: By analyzing the references and keywords, we summarized the hot topics and research trends in this field. These findings provide useful information for researchers to explore the relationship between hypertension and AD further, with the hope of providing more effective treatments for AD patients to delay disease progression and improve quality of life.
    Keywords:  Alzheimer’s disease; CiteSpace; VOSviewer; Web of Science; bibliometrics; hypertension
    DOI:  https://doi.org/10.3389/fneur.2025.1514054
  9. Front Microbiol. 2025 ;16 1548233
    Research trends and hotspots of metabolites and inflammatory bowel disease: a bibliometric analysis.
    Jia-Qi Lyu, Fang-Jun Xiao, Ke-Ying Wang, Ying-Jie Liu, Jing-Mei Hui, Jie Lin.
       Purpose: The purpose of this study is to analyze the current research status and explore the relationship between metabolites and inflammatory bowel disease (IBD), providing insights for future research.
    Methods: In this study, we retrieved publications on metabolites and IBD from the Web of Science Core Collection (WOSCC), covering the period from 1994 to 2024. We conducted descriptive and visual analyses of the topics, journals, countries/regions, institutions, authors, and citation counts of these publications.
    Results: From January 1994 to June 2024, a total of 509 relevant publications were retrieved from the WOSCC, with the number of publications steadily increasing each year. These articles were published in 222 journals, with the top three most productive journals being inflammatory bowel diseases (36 publications), Alimentary Pharmacology & Therapeutics (16 publications), and Digestive Diseases and Sciences (13 publications). The leading countries in publication output were China (154 publications, 30.3%), the USA (101 publications, 19.8%), and the UK (32 publications, 6.3%), with total citation counts of 3,175, 7,439, and 1,444, respectively. The most recent trending keywords in this field include "gut microbiota," "inflammation," and "pathogenesis."
    Conclusion: Recent research on the relationship between metabolites and inflammatory bowel disease (IBD) has grown significantly, deepening our understanding of their connection. Further exploration of this relationship could not only enhance the quality of life for IBD patients but also offer new insights into potential cures for the disease.
    Keywords:  bibliometric; hotspots; inflammatory bowel disease; metabolites; visual analysis
    DOI:  https://doi.org/10.3389/fmicb.2025.1548233
  10. Front Oncol. 2025 ;15 1571617
    Current research status and hotspots of precancerous lesions of gastric cancer: a bibliometric analysis.
    Yan Huang, Dexin Wang, Yuzhuo Liu, Xiaonan Xu, Li Chen, Zhuolin Ma, Zhaoxia Liu.
       Background: Gastric cancer is the fifth most common cancer worldwide, and its lack of specific symptoms presents a significant challenge for early diagnosis. Therefore, the identification and detection of precancerous lesions of gastric cancer (PLGC) are essential for its prevention. We performed a comprehensive bibliometric analysis to explore the research trends and emerging topics in this field, aiming to deepen our understanding of PLGC.
    Objective: This study utilizes a bibliometric approach with network analysis to explore the progress and trends in PLGC research. The findings aim to provide a foundation and guidance for further in-depth investigations into PLGC.
    Methods: This study used VOSviewer and CiteSpace software to collect relevant literature on PLGC from the Web of Science Core Collection, covering the period from 2005 to 2024. Data visualization analysis was performed on the number of publications, countries, institutions, journals, authors, keywords, and citation counts of these articles.
    Results: A total of 1,141 relevant articles were included in the analysis. The results showed a year-on-year increase in the number of publications from 2005 to 2024. The country, institution, author, and journal with the highest publication output in this field were China, Peking University, Wei-Cheng You, and World Journal of Gastroenterology, respectively. The most frequently occurring keywords in the PLGC field were "Helicobacter pylori," "intestinal metaplasia," "risk," "infection," and "atrophic gastritis." Additionally, "chronic atrophic gastritis" and "inflammation" have emerged as hot topics for future research.
    Conclusion: This bibliometric analysis highlights the hot topics and emerging trends in PLGC research, aiming to provide valuable guidance for future studies. Our findings indicate that mechanistic studies and clinical diagnosis will be key areas of focus in upcoming research.
    Keywords:  Citespace; Helicobacter pylori; VOSviewer; bibliometric; precancerous lesions of gastric cancer
    DOI:  https://doi.org/10.3389/fonc.2025.1571617
  11. J Ophthalmol. 2025 ;2025 8891531
    Sustainable Practices in Anti-VEGF Therapy: A 15-Year Bibliometric Analysis of Ranibizumab for Age-Related Macular Degeneration.
    Li Xiaodong, Chen Xia, Qin Xuewei, Wu Dandan, Yang Yi, Li Zhilin.
      Objective: A bibliometric analysis was performed in the domain of ranibizumab and age-related macular degeneration (AMD) to delineate current trends in international research dynamics and to provide a visual representation of research hotspots and challenges associated with ophthalmic drugs over the past 15 years. This study also evaluates the sustainability of ranibizumab therapy through reduced injection burden, cost-effectiveness compared to alternative treatments, and long-term outcomes that minimize healthcare resource utilization. Method: In this cross-sectional study, bibliometrics analyzed data retrieved and extracted from the Web of Science Core Collection (WOSCC) database to analyze the evolution and thematic trends in the delivery of studies from January 1, 2008, to September 2, 2023, for ranibizumab and AMD studies. A total of 2691 articles on the field were assessed for specific characteristics such as the year of publication, journal, author, institution, country/region, citation, and keywords. Co-authorship analysis, co-occurrence analysis, co-citation analysis, and network visualization were constructed using VOSviewer. Some important subtopics identified by bibliometric characterization were further discussed and reviewed. Results: From 2008 to 2023, the cumulative number of articles published globally increased from 1 to 2,691, with the highest number of articles published in 2020 (255 papers). RETINA THE JOURNAL OF RETINAL AND VITREOUS DISEASES published the most manuscripts (285 papers) and was cited (6496 citations), followed by OPHTHALMOLOGY (193 papers) and GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY (163 papers). OPHTHALMOLOGY was the most cited (20,865 citations), with the United States (786 papers, 38,014 citations), Univ Sydney (98 papers, 5245 citations), and Kim, Jong Woo (56 papers, 550 citations) being the most productive and influential institutions, countries, and authors, respectively. Five clusters were formed by summarizing the top 100 keywords, which marked the emerging frontier of ranibizumab and AMD-related research. Further discussion of the five clusters of research is to assist the researcher in determining the scope of the research topic and planning the direction of the research. Conclusion: Over the past two decades, there has been a notable increase in the number of publications and citations pertaining to ranibizumab and AMD across various countries, institutions, and authors. This study elucidates current trends, global collaboration patterns, foundational knowledge, research hotspots, and developmental trajectories within the realm of ranibizumab-related AMD research. Key advancements in AMD treatment with ranibizumab over the last 15 years have centered on less frequent injection schedules, extended drug efficacy, and enhanced safety profiles.
    Keywords:  aflibercept; age-related macular degeneration; bevacizumab; endothelial growth-factor; ranibizumab; sustainable practices
    DOI:  https://doi.org/10.1155/joph/8891531
  12. Health Care Anal. 2025 May 14.
    Data Privacy in Medical Informatics and Electronic Health Records: A Bibliometric Analysis.
    Kemal Hakan Gulkesen, Esra Tokur Sonuvar.
      This study aims to evaluate scientific publications on "Medical Informatics" and "Data Privacy" using a bibliometric approach to identify research trends, the most studied topics, and the countries and institutions with the highest publication output. The search was carried out utilizing the WoS Clarivate Analytics tool across SCIE journals. Subsequently, text mining, keyword clustering, and data visualization were applied through the use of VOSviewer and Tableau Desktop software. Between 1975 and 2023, a total of 7,165 articles were published on the topic of data privacy. The number of articles has been increasing each year. The text mining and clustering analysis identified eight main clusters in the literature: (1) Mobile Health/Telemedicine/IOT, (2) Security/Encryption/Authentication, (3) Big Data/AI/Data Science, (4) Anonymization/Digital Phenotyping, (5) Genomics/Biobank, (6) Ethics, (7) Legal Issues, (8) Cloud Computing. On a country basis, the United States was identified as the most active country in this field, producing the most publications and receiving the highest number of citations. China, the United Kingdom, Canada, and Australia also emerged as significant countries. Among these clusters, "Mobile Health/Telemedicine/IOT," "Security/Encryption/Authentication," and "Cloud Computing" technologies stood out as the most prominent and extensively studied topics in the intersection of medical informatics and data privacy.
    Keywords:  Bibliometrics; Cluster analysis; Data security; Medical informatics; Text mining
    DOI:  https://doi.org/10.1007/s10728-025-00519-0
  13. J Patient Rep Outcomes. 2025 May 14. 9(1): 54
    Research trends among new investigators at ISOQOL: a bibliometric analysis from 2019 to 2023.
    New Investigators Special Interest Group Members
       BACKGROUND: New investigators (NI), encompassing graduate students, recent doctoral graduates, and early-career faculty, are instrumental in advancing quality of life (QoL) research through innovative methodologies and diverse perspectives. Within the International Society for Quality of Life Research (ISOQOL), the New Investigators Special Interest Group (NI-SIG) fosters collaboration and supports this community. This study utilizes bibliometric analysis to examine the contributions of NI-SIG members, focusing on publication trends, collaboration patterns, and thematic developments in QoL research.
    METHODOLOGY: Data on publications authored by 56 NI-SIG members between 2019 and 2023 were extracted from Web of Science and Scopus. A two-step screening process, guided by the Wilson and Cleary model of QoL, identified 561 unique documents for analysis. Descriptive metrics included publication trends, citations, journal impact factors, and geographic distribution, while network analysis explored co-authorship patterns. Thematic mapping was conducted using clustering algorithms to identify established and emerging research areas.
    RESULTS: Publication output rose steadily from 2019 to 2022, peaking at 163 publications before declining to 135 in 2023, accompanied by a reduction in average citations per document from 4.8 to 1.3. The majority of publications appeared in leading journals such as Quality of Life Research (n = 128), Journal of Patient-Reported Outcomes (n = 17), and BMJ Open (n = 15). Geographic analysis revealed that most contributors were from high-income countries, with the United States, Canada, and Australia accounting for over 50% of publications. Co-authorship network analysis highlighted a robust, interconnected cluster of authors, though opportunities remain to enhance global partnerships, particularly with low- and middle-income countries. Thematic analysis identified well-established areas, including psychometric validation and cancer, alongside emerging topics such as mixed methods in QoL research.
    CONCLUSION: This study highlights robust collaborations among NI-SIG members while identifying opportunities to enhance international collaboration and methodological innovation. Expanding partnerships with underrepresented regions and embracing advanced technologies such as natural language processing could foster inclusivity and drive transformative advancements in QoL measurement and application.
    Keywords:  Bibliometric analysis; Citation patterns; Early career investigator; Health service research; Quality of life; Research collaboration
    DOI:  https://doi.org/10.1186/s41687-025-00878-1
  14. Clin Imaging. 2025 May 11. pii: S0899-7071(25)00105-6. [Epub ahead of print]123 110505
    Academic influence of American College of Radiology Appropriateness Criteria: a citation analysis of thoracic and cardiac imaging guidelines.
    Bradley Kasper, Christopher M Walker, Travis S Henry, Constantine Raptis, Brent P Little.
       PURPOSE: To evaluate the academic impact of the American College of Radiology thoracic and cardiac Appropriateness Criteria (ACR-AC) guideline publications through citation analysis.
    METHODS: The Scopus database was used to collect publication year, version number, and number and identity of citing publications for thoracic and cardiac imaging ACR-AC guideline publications. For each citing article, the journal name and impact factor, publication year, countries of all authors, and language(s) of publication were collected. An article h-index was computed for each ACR-AC guideline.
    RESULTS: 31 thoracic and cardiac ACR-AC guideline publications received 758 citations from 379 journals, with authors representing 62 countries. The median citation count was 15 (range = 1-97) and the median article h-index was 5 (range = 1-19). The most frequent country of authorship of articles citing an ACR-AC guideline publication was the United States, but 66.7 % of authors were from other countries. The median impact factor for the citing journals was 3.0 (range = 0.0-521.6). A majority of the total citations were from "Non-Radiology Journals" (n = 422/758 [55.7 %]) which comprised a majority of all journals represented (n = 295/379 [77.8 %]).
    CONCLUSIONS: Citation characteristics of ACR-AC guideline publications suggest broad multidisciplinary and global academic influence.
    Keywords:  ACR Appropriateness Criteria; American College of Radiology; Bibliometrics; Citation analysis; Radiology guidelines
    DOI:  https://doi.org/10.1016/j.clinimag.2025.110505
  15. J Med Imaging Radiat Sci. 2025 May 13. pii: S1939-8654(25)00110-9. [Epub ahead of print]56(5): 101960
    Global trends in radiography research: A bibliometric study of three key journals.
    Siddig Ibrahim Abdelwahab, Manal Mohamed Elhassan Taha, Abdullah Farasani, Saleh M Abdullah, Jobran M Moshi, Abrar Fahad Alshahrani, Nizar A Khamjan, Zenat A Khired, Ahmad Assiri, Ali Mohammed Alqassmi, Amal Mayudh Alhusayni, Ibrahim Abdel Aziz Ibrahim, Saeed Alshahrani, Waseem Hassan.
      Previous bibliometric studies of radiography journals have been limited in scope, covering selective time periods such as 1997-2011, 2013-2022, or 2004-2011, and analyzing relatively small datasets ranging from 706 to 1,830 articles with a few limitations. The present study examined 3,875 papers published in Radiography, Journal of Medical Imaging and Radiation Sciences, and Journal of Medical Radiation Sciences since their inclusion in the Scopus database. Quantitative bibliometric indicators, including publication counts, citation performance, and mean citations per article/year, were computed using the Bibliometrix package in R Studio. Co-authorship and institutional collaboration networks were visualized using VOSviewer. Keyword co-occurrence analysis was also conducted to identify dominant research areas and trace their evolution over time. Findings revealed a substantial rise in research output, increasing from 15 publications in 1995 to 456 in 2024. Citation impact peaked in 2017, with a gradual decline in subsequent years. The most prolific authors included Hogg P., Bolderston A., and Reed W., while the University of Salford, University of Toronto, and University of Sydney emerged as the leading institutions across the three journals. The United Kingdom, Canada, and Australia were dominant contributors, with a notable rise in participation from African and Asian countries. Funding was primarily supported by national health agencies, cancer-focused organizations, and academic institutions. Keyword analysis revealed nine major thematic clusters, including diagnostic imaging technologies, oncology, clinical practice, education, patient-centered care, and public health. Importantly, eight highly cited papers (≥100 citations) were identified, many of which contributed significantly to the professionalization of radiography, expanded the role of radiographers in diagnostic reporting, and integrated emerging technologies such as AI and digital imaging-marking key milestones in the field's development. In summary, this study presents the large-scale, journal-inclusive bibliometric profile of radiography research. It offers new insights into global contributions, and collaboration patterns, thus serving as a valuable foundation for shaping future research strategies.
    Keywords:  Bibliometric analysis; Citation analysis; Collaboration network; Keyword analysis; R studio; Radiography journals; Research productivity; Scopus; VOSviewer
    DOI:  https://doi.org/10.1016/j.jmir.2025.101960
  16. J Knee Surg. 2025 May 14.
    Anterior cruciate ligament Reconstruction with Lateral Extra-Articular Augmentation: A Bibliometric Analysis of The Top 100 Cited Articles.
    Osama Alzobi, Hamad Almannai, Ashraf Hantouly, Loay Salman, Abdulaziz F Ahmed, Khalid A Alkhelaifi, Bashir A Zikria.
      Background There has been significant exploration into anterior cruciate ligament (ACL) reconstruction with lateral extra-articular augmentation, with a marked increase in research output over the past ten years. Purpose This study aims to conduct a thorough bibliometric analysis of the most influential publications on ACL reconstruction combined with lateral extra-articular augmentation. Study Design This research is a cross-sectional study, classified as Level 4 evidence. Methods In July 2024, a thorough search was conducted utilizing the Web of Science Core Collection and Google Scholar databases to identify studies related to ACL reconstruction with lateral extra-articular augmentation. The 100 most cited articles that met the established inclusion criteria were carefully selected and subjected to an in-depth bibliometric analysis. Results The top 100 cited articles were published between 1976 and 2020, with a notable concentration during the 2010s. Citation counts for these articles ranged from 125 to 1000, with citation density varying between 3.32 and 113.00. The United States led in both the number of publications and citations, followed by France and Italy. The majority of the studies focused on anatomical and biomechanical topics, with a growing presence of high-level evidence studies, including 15 classified as level 1 or 2 evidence. Conclusion The period from 2010 to 2020 witnessed a significant surge in the publication of the top 100 most cited articles, highlighting their scientific relevance in specialized areas. The diversity of study types, predominantly anatomical and biomechanical, reflects the substantial interest in this field, coupled with an increase in high-evidence-level research, with 15 articles classified as level 1 or 2. The United States stands out, contributing 31% of these articles, with notable input from France and Italy. This review provides valuable insights into global research trends and outlines potential directions for future research.
    DOI:  https://doi.org/10.1055/a-2608-0220
  17. Discov Oncol. 2025 May 14. 16(1): 767
    Emerging trends and hotspots of tRNA-derived small RNAs in tumours: a bibliometric analysis via VOSviewer and CiteSpace.
    Junhong Wang, E-Ling Shao, Zhenhua Gao.
       INTRODUCTION: TRNA-derived small RNAs(tsRNAs) play an important role in many biological processes, and their dysregulation is closely related to the progression of cancer, but the research trend and future direction are not clear. This study aims to identify the leading contributors, collaboration networks, and emerging research trends in tsRNAs and their role in oncology, providing a more comprehensive and intuitive reference for researchers in this field.
    MATERIALS AND METHODS: Related publications related to tsRNA in the field of oncology from 1990 to 2022 were collected from the Science Citation Index Expanded through the Web of Science Core Collection (WOSCC) database on 6 December 2022.
    RESULTS: There were 2,108 publications related to tsRNAs in oncology. The articles came from 69 countries/regions, 2,218 institutions, 11,340 authors, and 200 journals, and included 9,530 keywords. The annual total number of papers and total global citation score increased steadily every year over the study period. Among the articles related to tsRNAs in oncology, the United States had the highest number of publications with 732 articles, and the United States, China, Japan, Canada, and South Korea had the highest number of collaborations. Seoul National University Sun and the journal Nucleic Acids Research had the most publications at 81 and 63 articles, respectively, and the keyword "tRF" was a hotspot.
    CONCLUSION: This study provides an in-depth analysis of the research status and development trends of tsRNAs in the field of cancer from a bibliometric perspective. Offering possible guidance for researchers to explore hot topics and frontiers, select suitable journals, and partners in this field.
    Keywords:  Bibliometric; Oncology; Visualisation; tRNA; tsRNAs
    DOI:  https://doi.org/10.1007/s12672-025-02628-7
  18. Clin Implant Dent Relat Res. 2025 Jun;27(3): e70041
    Maxillary Sinus Lift: A Bibliometric and Altmetric Analysis of the 100 Most Cited Articles.
    Caio Gomes Pereira, Lucas Menezes Dos Anjos, Aurélio de Oliveira Rocha, Natalia de Oliveira Miranda, Henrique César Schimitz Gassen, Mariane Cardoso, Bruno Henriques, Marco Aurélio Bianchini.
       AIM: To analyze the scientific profile of the 100 most cited articles on maxillary sinus lift.
    MATERIALS AND METHODS: A search was conducted in the Web of Science Core Collection database in February 2024. Two reviewers retrieved the 100 most cited articles. The number of citations for the articles was compared in the Scopus and Google Scholar databases. The VOSviewer software was employed to generate collaborative network maps for authors and keywords. Dimension was consulted to measure altimetry data. Google Trends was used to explore the global popularity of research on maxillary sinus lift.
    RESULTS: The number of citations ranged from 120 to 1259. The articles were published between the years 1991 and 2017. The most frequent study design was observational (21%), and the surgical technique was the lateral window (76%). The most used bone graft was autogenous (15%). The journal with the highest number of articles was Clinical Oral Implants Research (29%). The United States was the most prevalent country (27%), and New York University had the highest number of publications (8%). However, the European continent stood out (66%). Froum SJ was the author with the highest number of publications (6%). The most common keywords were "dental implants" (38%). Intense mentions were identified primarily on Mendeley. According to Google Trends, Ukraine was the country that researched maxillary sinus lift the most.
    CONCLUSION: It can be concluded that the 100 most cited articles on sinus elevation were observational studies that evaluated the lateral window technique for sinus elevation.
    Keywords:  bibliometric analysis; dental implant; maxillary sinus; sinus lift
    DOI:  https://doi.org/10.1111/cid.70041
  19. Front Neurol. 2025 ;16 1541459
    Global trends in cervical spondylosis research: a bibliometric analysis based on the Web of Science.
    Lin Jiang, Yu Xu, Zhijun Yang, Penghui Li, Youkang Dong, Guangzhi Yang.
       Objective: We aim to analyze the development trends in cervical spondylosis research and guide future studies. Cervical spondylosis, a standard neck disorder characterized by pain, nerve compression, and spondylosis, is highly prevalent, particularly among older individuals, due to the extensive use of electronic devices. Since treatment options are limited and surgery is considered a last resort, it is crucial to explore the current research status and identify areas for further investigation.
    Method: We conducted a bibliometric analysis of academic articles on cervical spondylosis published between 1980 and 2022. The analysis involved utilizing the Web of Science database and employing R software and a VOS viewer.
    Results: Our analysis revealed that neurosciences and neurology were the primary research focus, with participation from 62 countries. China had the highest number of publications, while the USA received the most citations. The Rothman Institute emerged as the most cited institution in neck pain research. The journal "Spine" had the highest publication count. Among authors, Mummaneni P. V. was the most cited, and Liu H. had the highest number of publications. The keyword "Spine" was the most frequently used.
    Conclusion: Our bibliometric study summarized the current research status of cervical spondylosis. Further investigations are warranted in diagnosis, treatment, prevention, non-surgical interventions, and rehabilitation. Promising areas of interest include artificial cervical discs, gene therapy, and stem cell therapy. Our study provides a framework for enhancing cervical spondylosis's diagnosis and treatment by addressing existing literature gaps.
    Keywords:  Web of Science; bibliometrix; cervical spondylosis; network analysis; research frontiers
    DOI:  https://doi.org/10.3389/fneur.2025.1541459
  20. Int J Urol. 2025 May 15.
    Research Landscape on Adrenocortical Carcinoma Over Four Decades.
    Tun-Pang Chu, Chi-Yu Kuo, Shih-Ping Cheng.
       OBJECTIVES: Adrenocortical carcinoma is a rare but devastating endocrine malignancy. Our objective was to outline the academic output and trends through bibliometric analysis.
    METHODS: We searched the Web of Science Core Collection, PubMed, and Scopus to retrieve publications related to adrenocortical carcinoma using the structured three-step PRISMA methodology. Co-authorship and co-occurrence analyses were conducted to visualize collaborative and thematic networks.
    RESULTS: This overview comprises 5507 documents. The number of publications on adrenocortical carcinoma has consistently increased over time. Most of these publications originate from North America and Europe. The co-occurrence map identified several major research clusters, with immunotherapy and targeted therapy emerging as new treatment modalities in recent years. The number of co-authoring institutions per publication was positively correlated with citation counts (Spearman's rank coefficient = 0.17, p < 0.0001).
    CONCLUSIONS: This literature analysis provides an overview of the current research landscape on adrenocortical carcinoma, highlighting geographical disparities. International and interdisciplinary collaboration may enhance productivity and foster scientific progress.
    Keywords:  Scopus; adrenocortical carcinoma; bibliometric analysis; web of science
    DOI:  https://doi.org/10.1111/iju.70117
  21. Digit Health. 2025 Jan-Dec;11:11 20552076251342165
    Bibliometric insights into the top 100 most-cited annual studies on digital health in nursing education (2020-2024).
    Chunxiu Zhou, Lili Ma.
       Aim: This study aims to use bibliometric methods to analyze highly cited nursing education articles on digital health, particularly those 100 top cited publications between 2020 and 2024, from the Web of Science (WOS) Core Collection.
    Design: A retrospective bibliometric analysis was conducted.
    Methods: A bibliometric analysis of the most-cited digital health articles on nursing education in English with the highest citations. Data were sourced from the WOS Core Collection. Analysis was conducted using Excel and SPSS, while VOSviewer was used to visualize keyword trends. The analysis included examining journal distribution, author patterns, research types, methodologies, and keyword trends.
    Results: The 100 most-cited articles were published between 1993 and 2024 by 91 different first authors from 22 countries. The United States contributed approximately 33% of the articles. Citation counts ranged from 198 to 1. Nurse Education Today was the most frequently cited journal. Review articles had higher average citations (50.96) compared to original articles (24.08). The focus of research has shifted from virtual reality (VR) to artificial intelligence (AI), with ChatGPT emerging as a new trend.
    Conclusion: Digital health is becoming a significant focus in nursing education research. While VR has been a dominant topic, AI is now emerging as a key research area. The findings provide insights into citation patterns and research trends, supporting future impactful studies in this field.
    Keywords:  bibliometric analysis; digital health; digital health technology; nursing education; social network analysis
    DOI:  https://doi.org/10.1177/20552076251342165
  22. Front Pharmacol. 2025 ;16 1564561
    Global trends in resistance studies of gemcitabine and pancreatic cancer: a bibliometric and visual analysis from 2010 to 2024.
    Dandan Gu, Shaoyang Huang, Kai Zhao, Xiaohong Zhang, Jinjing Zhang, Wei Xiong.
       Introduction: Pancreatic adenocarcinoma (PC) represents a prevalent and highly aggressive malignancy within the digestive system, characterized by an exceedingly poor prognosis and a dismal 5-year survival rate of below 7%. Gemcitabine (GEM) remains the cornerstone chemotherapeutic agent in the management of PC; however, the growing challenge of GEM chemoresistance, which undermines treatment efficacy, represents a significant obstacle in clinical practice. To date, no comprehensive bibliometric analysis has been undertaken to systematically explore studies on GEM resistance in the context of PC. This study aims to deliver a thorough evaluation of the research hotspots pertaining to GEM resistance in PCs.
    Method: A systematic search was conducted for articles published from 1 January 2010, to 15 December 2024, focusing on resistance studies of GEM in PC. Bibliometric analysis and visualization were performed utilizing VOSviewer and CiteSpace tools, applied to literature data extracted from the Web of Science Core Collection (WoSCC).
    Results: Between 2010 and 2024, a total of 2,689 papers were published across 472 institutions in 74 countries, reflecting a consistent upward trajectory in annual publication output. China and Fudan University emerged as the leading contributors to the research output on this topic, representing the most prolific country and institution, respectively. Giovannetti, Elisa, and Yu, Xianjun are the most prolific scholars in this field. Cancer Research stands out as the most cited and impactful journal, while research on the tumor microenvironment, targeted therapy, and circular RNA has emerged as a key focus area in recent years.
    Conclusion: This study provides a systematic and comprehensive overview of the literature on GEM resistance in PC over the past 15 years. This analysis offers scholars critical insights into the field from a bibliometric perspective, potentially informing future studies on the development of chemotherapeutic treatments for PC.
    Keywords:  VOSviewer; bibliometric analysis; citespace; drug resistance; gemcitabine; pancreatic cancer
    DOI:  https://doi.org/10.3389/fphar.2025.1564561
  23. Front Oncol. 2025 ;15 1567806
    Fertility-sparing treatment for patients with endometrial cancer: a bibliometric analysis from 2000 to 2024.
    Yue Gao, Huali Wang, Meng Jiang, Yumeng Cui, Xiaochuan Yu.
       Introduction: The rising global incidence of endometrial cancer (EC), particularly among younger patients, has established fertility-sparing treatment as a critical focus in gynecological and reproductive medicine. Despite its clinical significance, comprehensive bibliometric analyses in this field remain limited.
    Methods: This study conducted the most extensive bibliometric analysis to date, encompassing 506 publications on fertility-sparing EC treatments published between January 1, 2000, and December 22, 2024. Utilizing CiteSpace, JepaC, and VOSviewer, we systematically evaluated contributions across regions, institutions, journals, authors, and keywords to identify emerging research trends.
    Results: China and the United States emerged as leading contributors, collectively accounting for 44.3% of publications. Fudan University and Cha University were identified as the most active institutions. Author Chen Xiaojun demonstrated the highest publication output, while Seok J and Seong SJ ranked as the most frequently cited researchers. Keyword analysis revealed five dominant research themes: "progestin," "reproductive outcomes," "age," "prognostic factors," and "myometrial invasion."
    Discussion: This analysis delineates the evolving landscape of fertility-sparing EC research, highlighting persistent emphasis on hormonal therapies and prognostic determinants. The findings underscore the need for standardized treatment protocols and long-term fertility outcome studies. By mapping research trajectories and visualizing knowledge networks, this study provides actionable insights to guide future investigations in reproductive oncology.
    Keywords:  bibliometric analysis; endometrial cancer; fertility-sparing treatment; molecular classification; progestin
    DOI:  https://doi.org/10.3389/fonc.2025.1567806
  24. Healthcare (Basel). 2025 May 06. pii: 1067. [Epub ahead of print]13(9):
    Bibliometric Analysis of Cross-Sectional Studies on Early Childhood Caries.
    Rana A Alamoudi.
       BACKGROUND/OBJECTIVES: Early childhood caries (ECC) is a significant global public health issue with economic and psychosocial consequences, impacting families and pediatric dentists. It affects children's quality of life, causing pain and infection. Despite increasing research on ECC cross-sectional studies worldwide, inconsistencies and gaps remain in terms of geographical disparities. This study aimed to conduct a bibliometric analysis of cross-sectional surveys on ECC by examining the co-authorship, citation analysis, co-citation networks, and keyword co-occurrence.
    METHODS: An advanced search was performed using relevant terms in the Dimensions database from 2005 to 2024. Bibliometric parameters were retrieved through the database's analytical view tool and VOSviewer software.
    RESULTS: A total of 571 documents were identified, with the highest output between 2019 and 2023 (355 records). Saul Martins Paiva authored the most articles (10), with 294 citations and a total link strength of 19. Brazil and the U.S. had the highest numbers of publications (56 and 52) and total link strengths, i.e., a measure of collaborative ties (21 and 50). The Universidade Federal de Minas Gerais in Brazil had the most published documents (15). BMC Oral Health led in terms of citations (44 articles, 899 citations, average 20.43%). The frequently co-occurring terms included ECC (1147 occurrences), oral health (417), and preschool child (301).
    CONCLUSIONS: This bibliometric analysis highlights the global interest in cross-sectional ECC studies beyond pediatric dentistry, helping researchers understand the field's scope and progress.
    Keywords:  VOSviewer; bibliometric analysis; co-authorship; co-citation; early childhood caries
    DOI:  https://doi.org/10.3390/healthcare13091067
  25. Front Neurol. 2025 ;16 1568022
    Mapping the intersection of HIV and Alzheimer's disease: a bibliometric analysis of emerging research trends.
    Hao Zhang, ShuYou Yuan, HongXia Bao, WenJun Chen, Bo Cai, JunKai Sun, HaoGang Zhu, Wei Lu.
       Background: HIV and Alzheimer's disease (AD) are significant global health challenges with overlapping neuroinflammatory and protein aggregation mechanisms. Understanding their intersection is critical for advancing therapeutic strategies, particularly in aging populations.
    Objective: This study aims to provide a comprehensive bibliometric analysis of research trends at the intersection of HIV and AD, identify emerging themes, and highlight key contributors in this interdisciplinary field.
    Methods: Using the Web of Science Core Collection, we retrieved 4,856 articles and reviews published between 1994 and 2025. Bibliometric analysis was conducted with VOSviewer, CiteSpace, and R software to examine publication trends, international collaboration, institutional contributions, journal dynamics, author networks, and thematic evolution.
    Results: The analysis reveals a 14.18% annual growth rate in publications, with the U.S. leading in productivity, followed by China, Germany, and Japan. Key institutions include the NIH and the University of California System, while journals such as Journal of Biological Chemistry and PLOS ONE show significant growth. Prominent authors include Masliah, Eliezer, and Heaton, RK. Research highlights the overlap between HIV-associated neurocognitive disorders (HAND) and AD, emphasizing shared mechanisms like neuroinflammation, protein aggregation, and blood-brain barrier disruption. Recent advances focus on cerebrospinal fluid biomarkers, oxidative stress, and the impact of antiretroviral therapy (ART) on neurological outcomes. Studies increasingly explore the role of advanced methodologies, including machine learning, in elucidating shared mechanisms such as neuroinflammation, endoplasmic reticulum stress, and protein misfolding.
    Conclusion: This bibliometric analysis underscores the dynamic and rapidly evolving research landscape at the intersection of HIV and AD, driven by collaborative efforts and technological advancements. Future research should prioritize longitudinal studies, mechanistic insights, and translational applications to address unanswered questions in this critical field.
    Keywords:  Alzheimer’s disease; HAND; HIV; aging HIV population; bibliometrics; blood–brain barrier; neuroinflammation; protein aggregation
    DOI:  https://doi.org/10.3389/fneur.2025.1568022
  26. Discov Oncol. 2025 May 14. 16(1): 763
    Research on the developments of artificial intelligence in radiomics for oncology over the past decade: a bibliometric and visualized analysis.
    Pengyu Zhang, Lili Wei, Zonglong Nie, Pengcheng Hu, Jilu Zheng, Ji Lv, Tao Cui, Chunlei Liu, Xiaopeng Lan.
       OBJECTIVE: To assess the publications' bibliographic features and look into how the advancement of artificial intelligence (AI) and its subfields in radiomics has affected the growth of oncology.
    METHODS: The researchers conducted a search in the Web of Science (WoS) for scientific publications in cancer pertaining to AI and radiomics, published in English from 1 January 2015 to 31 December 2024.The research included a scientometric methodology and comprehensive data analysis utilising scientific visualization tools, including the Bibliometrix R software package, VOSviewer, and CiteSpace. Bibliometric techniques utilised were co-authorship, co-citation, co-occurrence, citation burst, and performance Analysis.
    RESULTS: The final study encompassed 4,127 publications authored by 5,026 individuals and published across 597 journals. China (2087;50.57%) and USA (850;20.6%) were the two most productive countries. The authors with the highest publication counts were Tian Jie (60) and Cuocolo Renato (30). Fudan University (169;4.09%) and Sun Yat-sen University (162;3.93%) were the most active institutions. The foremost journals were Frontiers in Oncology and Cancer. The predominant author keywords were radiomics, artificial intelligence, and oncology research.
    CONCLUSION: Investigations into the integration of AI with radiomics in oncology remain nascent, with numerous studies concentrating on biology, diagnosis, treatment, and cancer risk evaluation.
    Keywords:  Artificial intelligence; Bibliometric analysis; Deep learning; Oncology; Radiomics
    DOI:  https://doi.org/10.1007/s12672-025-02590-4
  27. J Mater Sci Mater Med. 2025 May 14. 36(1): 39
    Advances in hydrogel research: a 25-year bibliometric overview.
    Dongbin Zhang, Mengru Qiu, Yu Tian, Shuo Zhang, Fan Wu.
      This study presents a comprehensive bibliometric analysis of hydrogel research from 2000 to 2025, examining 101,291 publications from the OpenAlex database to highlight the field's evolution, trends, and impact, providing a better landscape of the field. The analysis demonstrates significant growth in the research output, from ~350 publications in 2000 to nearly 11,000 in 2024, with 37% being open access. Publication patterns demonstrate Physical Sciences leading with about 50,000 publications, followed by Life Sciences (~30,000) and Health Sciences (~21,000). The citation analysis emphasizes that 20% of all citations result from the top 1% of papers, demonstrating the concentration of the research impact. The study identifies key research hubs, with China as a leader in the publication (27,931 publications), while the United States maintains the highest citation impact (>1 million citations). Network analysis reveals increasingly complicated international collaborations, particularly between the United States and China. Topic modeling using Latent Dirichlet Allocation identifies 17 distinct research themes, emphasizing the field's diversification from fundamental material features to advanced applications in the tissue engineering, drug delivery, and regenerative medicine. This analysis provides valuable insights into the dynamic landscape of hydrogel research, highlighting opportunities for future innovation and collaboration.
    DOI:  https://doi.org/10.1007/s10856-025-06887-2
  28. Otol Neurotol. 2025 May 07.
    The Top 100 Cited Articles in Otology and Neurotology and Analysis of Female Authorship.
    Helia Rahimian, Khushi Bhatt, Karen Tawk, Yalda Yazdani, Hamid R Djalilian, Mehdi Abouzari.
       INTRODUCTION: Despite the increasing number of female trainees in otology and neurotology, women remain underreported in academic medicine. This gender disparity persists in high-impact research, where women are less represented as first and corresponding authors.
    METHODS: The top 100 most-cited articles from Otology & Neurotology (1980-2024) were identified using total citation counts. First and corresponding author gender was determined, and trends in female authorship were analyzed over time.
    RESULTS: A total of 7,485 Otology & Neurotology articles published between 1980 and 2024 were reviewed and the top 100 cited studies (1.3%) were identified. Women accounted for 29% of first authors and 23% of corresponding authors, with a significant increase in female authorship over time. However, overall representation remains disproportionately low.
    DISCUSSION: Our study highlights the persistent underrepresentation of women in otology and neurotology research, despite their growing presence in medicine. Additional efforts are needed to promote greater inclusivity in academic literature of otology and neurotology.
    Keywords:  Citation; Female; Impact; Neurotology; Otology
    DOI:  https://doi.org/10.1097/MAO.0000000000004507
  29. Ann Gen Psychiatry. 2025 May 14. 24(1): 27
    Bibliometric and visual analysis of circadian rhythms in depression from 2004 to 2024.
    Cong Zhou, Shanling Ji, Aoxue Zhang, Hao Yu, Chuanxin Liu, Sen Li.
       INTRODUCTION: Understanding the intricate relationship between circadian rhythms and depression is crucial for developing effective interventions and treatments for individuals affected by depression. Circadian rhythms regulate various physiological and behavioral processes, while depression manifests as persistent feelings of sadness and disturbances in sleep, appetite, and energy levels. Emerging research suggests a significant interplay between circadian rhythm disruption and depression, highlighting the need for comprehensive analysis in this area.
    METHODOLOGY: A bibliometric and visual analysis of literature on circadian rhythms in depression from 2004 to 2024 was conducted using the Web of Science Core Collection. Data were analyzed using bibliometric tools including VOSviewer, CiteSpace, and Bibliometrix to identify publication trends, geographical distribution, authorship patterns, institutional collaborations, journal preferences, keyword co-occurrence, and highly cited references.
    RESULTS: Analysis revealed a steady increase in publications and citations related to circadian rhythms in depression. The United States emerged as the leading contributor, with strong global collaborations. Key journals included Chronobiology International and Journal of Affective Disorders. Top keywords included circadian rhythm, depression, sleep, melatonin, and bipolar disorder. The most cited article is a review titled "Practice parameters for the indications for polysomnography and related procedures: An update for 2005".
    CONCLUSIONS: This study offers a comprehensive overview of research on circadian rhythms in depression, highlighting key trends, contributors, and interdisciplinary intersections.
    Keywords:  Bibliometric; Circadian rhythms; Depression; Visualize
    DOI:  https://doi.org/10.1186/s12991-025-00565-x
  30. Cureus. 2025 Apr;17(4): e82294
    Global Publication Pattern in Ankle Arthroscopy: A Scopus®-Indexed Bibliometric Visualization Analysis.
    Tauseef Ahmad, Kaylem M Feeney.
      Ankle arthroscopy has become a common procedure performed by foot and ankle surgeons worldwide in the evaluation and management of ankle pathology. This study aimed to assess and characterize the global trends and network collaboration in ankle arthroscopy research. A retrospective bibliometric study was conducted using predefined keywords. The data utilized in this study were extracted from the Scopus® database. The data were imported into Bibliometrix, an R-tool for prerequisite analysis and network collaboration mapping. A total of 938 peer-reviewed publications (original articles = 778, review articles = 160) were analyzed and characterized. The included articles were published in English between 1973 and 2021. These articles were published in 175 journals and were authored by 2,708 authors. The collaboration index among the authors was 3.08. The most frequent year of publication was 2020 (n = 84). The overall annual scientific growth rate was 10.41%. The top-ranked core journal in ankle arthroscopy was "Foot and Ankle International" (n = 121). The most frequently appeared affiliations were North District Hospital (n = 50), Harvard Medical School (n = 46), and University of Amsterdam (n = 44). The largest number of publications was produced in the United States (n = 376), followed by the United Kingdom (n = 107) and Japan (n = 68). The most studied trend topics were arthroscopy, human, male, adult, and female. The largest portion of the included publications was produced in developed countries, although it is possible that the exclusion of studies published in a language other than English may have influenced these results. The United Kingdom had the strongest collaboration with Italy, France, and Spain. However, the United States had the strongest collaboration with Italy, Spain, and the United Kingdom.
    Keywords:  analysis; ankle and foot; arthroscopy; bibliometrics; network collaboration
    DOI:  https://doi.org/10.7759/cureus.82294
  31. J Prof Nurs. 2025 May-Jun;58:pii: S8755-7223(25)00024-9. [Epub ahead of print]58 51-60
    Trends and hotspots of design thinking in nursing research: A bibliometric analysis.
    Dongyu Wang, Jiayi Zhu, Xiaofeng Xie, Ruben Martin-Payo, Linyan Xu, Fengying Zhang.
       BACKGROUND: The increasing research on design thinking in nursing underscores its potential to improve patient care and optimize healthcare systems. However, a comprehensive bibliometric analysis of this emerging field is still lacking.
    PURPOSE: This study aims to provide a thorough overview of existing research on design thinking in nursing using bibliometric indicators to examine trends and draw insights.
    METHODS: VOSviewer was used to conduct a bibliometric analysis, providing insights into the characteristics of the academic literature on design thinking in nursing. This study analyzed the literature from the inception of the database until March 20, 2024, using sources from the Web of Science Core Collection and the Cumulative Index to Nursing and Allied Health Literature database.
    RESULTS: The results reveal a substantial increase in research on design thinking in nursing, with 264 publications contributed by 1477 authors representing 634 organizations across 47 countries. These articles were published across 190 journals and referenced 10,093 sources from 5153 journals. The United States led in search contributions with 117 publications, while Stanford University stood out as the most prolific institution, averaging 40.3 citations per publication, highlighting its significant influence in the field. The study primarily explores broad themes in nursing, emphasizing key areas such as human-centered design, digital health, telemedicine, artificial intelligence (AI), education, innovation, and quality improvement. These findings reflect the increasing recognition of design thinking as a vital approach to enhancing nursing practice and education.
    CONCLUSION: This study highlights the growing global focus on design thinking in nursing, with Western regions emerging as key contributors to research in the field. The recognition of key areas, including human-centered design, digital health, telemedicine, AI, education, innovation, implementation science, and quality improvement, underscores the need for nursing to advance its design thinking approaches. The results emphasize the importance of nursing educators and practitioners adopting and integrating design thinking principles, as this approach can significantly improve educational outcomes and patient care.
    Keywords:  Artificial intelligence; Bibliometrics; Design thinking; Innovation; Nursing; Visual analysis
    DOI:  https://doi.org/10.1016/j.profnurs.2025.02.005
  32. Front Immunol. 2025 ;16 1546704
    Trends and hotspots on hymenoptera venom immunotherapy: a bibliometric and visualized analysis of research from 2014 to 2024.
    Yun Luo, Minxia Guan, Yichuan Yu.
       Objective: Recently, the application of hymenoptera venom immunotherapy (VIT) has been extensively studied in the medical community. Nevertheless, there are still very few bibliometric analyses devoted to this field. Therefore, this study aims to provide a comprehensive overview of the development of research in the past 11 years and clarify future research directions and trends.
    Methods: From 2014 to 2024, articles related to "hymenoptera venom immunotherapy "and "Allergy" were from the core collection of Web of Science. This visual analysis included examining annual productivity, cooperation between countries and institutions, co-cited references, author and journal cooperation networks, keyword co - occurrence, and their respective clustering and trends.
    Results: A total of 332 articles on the allergy caused by hymenoptera VIT were included in this study. Germany, Azienda Ospedaliera Universitaria Integrata Verona and Golden, David B K are the most productive countries and institutions respectively. Analysis of the top 10 literatures with co-citation frequency found that 4 were expert consensus and guidelines, 4 were single-center (or multi-center), open, randomized controlled trials, and 2 were systematic reviews. Keyword cluster analysis showed that wasps were identified as the primary focus of hymenoptera VIT in the past, and mastocytosis and hymenopteran venom allergy were the current research hotspots.
    Conclusion: Recent studies on hymenoptera VIT have shown that today's VIT increasingly emphasizes individualized and refined treatment. However, there is a lack of evidence of multicenter randomized controlled trials (RCTs) in this field. Further investigation is warranted to bridge this research gap.
    Keywords:  CiteSpace; allergy; bibliometric analysis; hymenoptera; venom immunotherapy
    DOI:  https://doi.org/10.3389/fimmu.2025.1546704
  33. J Relig Health. 2025 May 15.
    Teaching Spirituality in Nursing: Additional Evidence for Developing a Bibliometric Analysis.
    Siddig Ibrahim Abdelwahab, Manal Mohamed Elhassan Taha, Abdullah Farasani, Saleh M Abdullah, Jobran M Moshi, Nizar A Khamjan, Abrar Fahad Alshahrani, Zenat A Khired, Ahmad Assiri, Saeed Alshahrani, Abdelkhalig Hussein Elhilu, Waseem Hassan.
      Building upon previous bibliometric studies, this analysis expands the dataset and refines analytical methods to offer deeper insights into spirituality in nursing education. Using bibliometric techniques with Scopus, VOSviewer, and R Studio, 1227 papers were analyzed to identify key author contributions, leading institutions, and international collaborations. A comprehensive co-word analysis of the top 100 most cited papers revealed evolving research dynamics, mapping at least 50 key terms through uni-gram, bi-gram, and tri-gram approaches. Based on keyword analysis and their frequency of appearance, a generalized theme emerged around the significance of spiritual care in healthcare. The findings emphasized spiritual care's significance, particularly in palliative and end-of-life care, with growing integration into nursing education. Research explored its impact on clinical practice, patient well-being, and nursing perceptions, as well as how academic training prepares students for spiritual care. Various studies examined its effects on patient outcomes, coping strategies, and assessment tools. Beyond spirituality, broader healthcare topics, including mental health and pediatric palliative care, were addressed. Challenges in nursing education and innovative teaching strategies were also explored. This study advances the bibliometric understanding of spirituality in nursing education by uncovering thematic shifts, strengthening research methodologies, and broadening the scope of analysis in spiritual and holistic care education.
    Keywords:  Author collaboration; Bibliometric analysis; Citation metrics; Co-word analysis; Network analysis; Nursing education; Regional disparities; Research trends; Spirituality in nursing; Thematic mapping
    DOI:  https://doi.org/10.1007/s10943-025-02339-x
  34. J Multidiscip Healthc. 2025 ;18 2603-2627
    Research Advance of Causal Inference in Clinical Medicine: A Bibliometrics Analysis via Citespace.
    Guoqiang Qin, Jianxiang Wei, Yuehong Sun, Wenwen Du.
       Objective: Causal inference in clinical medicine provides scientific evidence for precision medicine and individualized treatment by revealing the true associations between interventions and health outcomes. This study aims to conduct a comprehensive bibliometric analysis to identify current research trends, primary themes, and future directions for the application of causal inference in clinical medicine.
    Methods: We conducted a literature search in the Web of Science database using causal inference and medical terminology as subject keywords, covering the period from January 1986 to December 2024. After screening, we obtained 4,316 documents for analysis. Utilizing CiteSpace to generate network diagrams, we analyzed data related to the number of publications, citation analysis, collaboration relationships, keyword co-occurrence, and highlighted terms to illustrate the knowledge map and collaboration network in this field.
    Results: Publications on medical causal inference shows a fluctuating growth trend over time. The United States was the top contributors to this field. Harvard University is the leading research institution. George David Smith is the most prolific author, Robbins JM is the most cited scholar. The major research hotspots concentrated in fields such as epidemiology, coronary heart disease and health. Notably, marginal structural models, counterfactual forecasting, and Mendelian randomization have consistently been key methodologies in research. The burstness of keywords reveals that big data, DNA methylation, and robust estimation are emerging research directions.
    Conclusion: In clinical research, counterfactual forecasting provides prospective guidance for optimizing clinical strategies; Mendelian randomization helps uncover potential therapeutic targets; and marginal structural models enhance the accuracy of causal effect estimation in clinical studies. The future integration of various data sources to improve causal inference methods is anticipated to enhance the sensitivity and specificity of trials, ultimately elucidating the complex mechanisms of diseases and drug effects. The literature retrieve strategy and the metrics of the tools adopted may have a certain impact on the results of this study.
    Keywords:  Mendelian randomization; bibliometrics; causal inference; counterfactual; marginal structural model
    DOI:  https://doi.org/10.2147/JMDH.S516826
  35. Int J Biol Macromol. 2025 May 12. pii: S0141-8130(25)04711-7. [Epub ahead of print] 144159
    Bibliometric analysis of advances in polysaccharide pharmacology research: A review.
    Jiameng Yang, Siyuan Lei, Yanhong Wei, Yaoxuan Li, Rutong Wang, Haoxuan Xue, Qiumei Huang, Kongwei Huang, Xiaocan Lei.
      Polysaccharide pharmacology has attracted considerable scholarly interest due to its wide range of pharmacological activities, with notable examples such as heparin's anticoagulant mechanisms via antithrombin III interactions and its emerging role in tumor microenvironment modulation. This study presents a bibliometric analysis of the literature pertinent to polysaccharide pharmacology, aiming to elucidate key insights within this research field. Utilizing the Web of Science database, we applied bibliometric analysis methods and utilized tools such as CiteSpace and VOSviewer to systematically investigate the current research landscape, hotspots, and developmental trends in polysaccharide pharmacology. This bibliometric study analyzed 2418 Web of Science publications (2006-2024) using CiteSpace and VOSviewer, revealing China, the US, Germany, and India as leading contributors. The identified keywords are categorized into four clusters: (1) "Anti-inflammatory and anticoagulant properties of polysaccharides," (2) "Multi-omics analysis of polysaccharides", (3) "Pharmacology and bioactivity of natural plants," and (4) "Applications of polysaccharide derivatives." Current research priorities focus on immunomodulation, including dual roles of lipopolysaccharides (LPS) as both endotoxins and immunomodulators in vaccine development, anti-tumor activities leveraging heparin's tumor microenvironment regulation, and drug delivery. This study offers a comprehensive analysis of polysaccharide pharmacology, with the objective of advancing mechanistic understanding in foundational research and facilitating clinical translation within this field.
    Keywords:  Bibliometric analysis; H-index; Hotspot; Polysaccharide pharmacology; Web of Science Core Collection
    DOI:  https://doi.org/10.1016/j.ijbiomac.2025.144159
  36. SAGE Open Med. 2025 ;13 20503121251336304
    Assessing academic impact through a bibliometrics analysis: Gastroesophageal reflux disease in the context of obesity treatment and bariatric surgery.
    Akbayan Imanbayeva, Bazylbek Zhakiev, Asset Yelemessov, Kairat Adaibayev, Kymbat Tussupkaliyeva, Dulat Turebayev, Saltanat Urazova, Laura Mamesheva, Alireza Afshar.
       Aims: The global rise in obesity rates has led to increased use of bariatric surgery, which can potentially exacerbate or induce gastroesophageal reflux disease. This study aimed to assess the academic impact and trends in research on gastroesophageal reflux disease in the context of obesity treatment and bariatric surgery through a comprehensive bibliometric analysis.
    Materials and methods: A bibliometric analysis was conducted using data from Web of Science and Scopus databases, covering publications from 1993 to 2024. The study utilized the Bibliometrix R package to analyze publication trends, collaborative networks, and research topics.
    Results: The analysis encompassed 257 documents from 82 sources, with 6192 total citations and an 8.2% annual growth rate in publications. The United States emerged as the leading contributor with 90 publications. Key research topics included bariatric surgery, sleeve gastrectomy, and gastroesophageal reflux disease, with increasing focus on complications and revisional bariatric surgery in recent years. Two main research clusters were identified: one focusing on general health aspects and demographics, and another on specialized bariatric procedures and outcomes. However, the analysis is constrained by its reliance on data from only two bibliographic databases, which may not encompass all pertinent studies, and by a geographic bias toward high-income countries. Moreover, our deep literature reviews highlighted that obesity is a known risk factor for gastroesophageal reflux disease, and while Roux-en-Y gastric bypass often reduces gastroesophageal reflux disease symptoms, sleeve gastrectomy may exacerbate or cause de novo gastroesophageal reflux disease postoperatively.
    Conclusions: This bibliometric study reveals a significant increase in research activity on gastroesophageal reflux disease in relation to obesity treatment and bariatric surgery, particularly since 2017. The findings highlight the growing importance of this field and the need for continued international research efforts to optimize surgical protocols and improve patient outcomes.
    Keywords:  Bariatric surgery; bibliometric analysis; gastroesophageal reflux diseases; obesity management; publication trends
    DOI:  https://doi.org/10.1177/20503121251336304
  37. Front Med (Lausanne). 2025 ;12 1572338
    Cardiac surgery-associated acute kidney injury: a decade of research trends and developments.
    Changlong Qiao, Jing Zhou, Chuansong Wei, Jing Cao, Ke Zheng, Meng Lv.
       Background: Cardiac surgery-associated acute kidney injury (CSA-AKI) significantly increases postoperative mortality and healthcare costs. Despite the growing volume of CSA-AKI research, the field remains fragmented, with challenges in identifying high-impact studies, collaborative networks, and emerging trends. Bibliometric analysis addresses these gaps by systematically mapping knowledge structures, revealing research priorities, and guiding resource allocation for both researchers and clinicians.
    Method: We analyzed 4,474 CSA-AKI-related publications (2014-2023) from the Web of Science Core Collection (WoSCC) using VOSviewer, CiteSpace, the Bibliometrix Package in R, and the bibliometric online analysis platform.
    Results: Annual publications increased steadily, with the USA and China leading productivity. The Journal of Cardiothoracic and Vascular Anesthesia serves as the foremost preferred journal within this domain. Critical Care (IF = 15.1) has the highest impact factor. Yunjie Li published the most papers. John A Kellum has the highest H-index. The definition, pathogenesis or etiology, diagnosis, prediction, prevention and treatment, which are the research basis in CSA-AKI. Machine learning (ML) and prediction models emerged as dominant frontiers (2021-2023), reflecting a shift toward personalized risk stratification and real-time perioperative decision-making. These advancements align with clinical demands for early AKI detection and precision prevention.
    Conclusion: This study not only maps the evolution of CSA-AKI research but also identifies priority areas for innovation: multicenter validation of predictive models to strengthen generalizability, preventive nephrology frameworks for long-term AKI survivor monitoring, and randomized controlled trials to confirm efficacy of machine learning-based CSA-AKI prediction tools.
    Keywords:  CiteSpace; VOSviewer; acute kidney injury; bibliometric; cardiac surgery
    DOI:  https://doi.org/10.3389/fmed.2025.1572338
  38. Discov Oncol. 2025 May 12. 16(1): 737
    Research trends and hotspots of single nucleotide polymorphisms in endometrial cancer: a bibliometric analysis.
    Renjie Wang, Zhihong Jia, Liang Peng, Jinghui Xu, Qiying Zhu, Yinghong Wu.
       BACKGROUND: Endometrial cancer (EC) is a common gynecological malignancy with increasing incidence, especially in developed nations. Understanding genetic variations, particularly single nucleotide polymorphisms (SNPs), is crucial for uncovering the disease's pathogenesis, progression, and treatment responses. This study explores the global research landscape of SNPs in EC, focusing on field evolution, key contributors, and emerging trends.
    METHODS: A systematic search of the Web of Science Core Collection (WoSCC) retrieved 838 publications on SNPs in EC from 1991 to 2024. Bibliometric indicators, including publication volume, citation counts, and keyword occurrences, were analyzed using VOSviewer, CiteSpace, and the R package "bibliometrix" for visual mapping and trend analysis.
    RESULTS: The United States (230 publications) and China (182 publications) were leaders in research output. Harvard University and the National Cancer Institute were prominent contributors. Key themes included "microsatellite instability" (a hallmark of DNA mismatch repair deficiency) and "genome-wide association studies" (GWAS), identifying susceptibility loci like HNF1B and CYP19A1. Recent trends, such as "Mendelian randomization," have enhanced causal inference in risk factor studies. SNP research has advanced risk prediction models and personalized therapeutic strategies, such as hormone therapy tailored to genetic profiles.
    CONCLUSION: SNP research has deepened our understanding of EC's genetic basis, with a growing emphasis on Mendelian randomization and GWAS. These advancements have refined risk prediction and opened new avenues for personalized medicine. Integrating SNP data with environmental and hormonal factors remains crucial for advancing prevention, diagnosis, and treatment strategies in EC.
    Keywords:  Bibliometric analysis; Endometrial cancer; Personalized medicine; Single nucleotide polymorphisms
    DOI:  https://doi.org/10.1007/s12672-025-02583-3
  39. Front Med (Lausanne). 2025 ;12 1488817
    A bibliometric analysis of strabismus (from 2004 to 2023).
    Yanghui Xiu, Yujie Zhang, Yu Su, Chufan Zhu, Zhen Liu.
      Over the past two decades, strabismus research has evolved significantly, driven by innovations in AI-assisted diagnostics, minimally invasive surgical techniques, and a heightened focus on psychosocial outcomes and systemic disease linkages. This bibliometric analysis of 4,515 articles from the Web of Science Core Collection (2004-2023) maps global research trends, identifying the United States of America (USA), China, and the United Kingdom (UK) as leading contributors. A keyword co-occurrence analysis highlights a shift toward innovative treatments, including non-surgical interventions, and highlights the growing interest in interdisciplinary approaches that integrate clinical practice with psychological and social dimensions of strabismus. In conclusion, this bibliometric review provides a comprehensive overview of current strabismus research and identifies key areas for further investigation, serving as a valuable resource for researchers and clinicians aiming to advance the field.
    Keywords:  CiteSpace; Web of Science Core Collection; bibliometrics analysis; research hotspots; strabismus
    DOI:  https://doi.org/10.3389/fmed.2025.1488817
  40. In Silico Pharmacol. 2025 ;13(2): 75
    Zebrafish and bioactive compounds: a bibliometric review.
    João Paulo Lima de Oliveira, Kiara Cândido Duarte da Silva, Bianca Aparecida de Sousa, William Franco Carneiro, Moises Silvestre de Azevedo Martins, Luis David Solis Murgas, Elisângela Elena Nunes Carvalho.
      Bibliometrics has become a crucial tool for evaluating and analyzing researchers' output. In recent decades, zebrafish has demonstrated its potential for studying oxidative stress, and the use of medicinal plants has proven essential in this context, as they are endowed with bioactive compounds that possess antioxidant properties. Thus, the aim of this study was to conduct a bibliometric review to analyze the evolution of publications concerning the concepts of "zebrafish" and "bioactive compounds." The Web of Science (WoS) database was utilized. Data on authors, countries, most cited journals, co-authorship between countries and authors, co-occurrence of keywords, keyword co-occurrence by publication year, and co-citation of references were analyzed using VOSviewer software. A total of 170 documents were retrieved, spanning the years 2004 to 2024. Jean Luc Wolfender, the United States, and PLoS One were prominent among the authors, countries, and journals with the highest citations, respectively. Among the co-occurrence of keywords, the following were noteworthy: zebrafish (n = 60), bioactive compounds (n = 12), angiogenesis (n = 9), antioxidant (n = 8), oxidative stress (n = 8), apoptosis (n = 7), antioxidant activity (n = 7), and toxicity (n = 7). It was concluded that the highest number of published documents was observed in 2022. Moreover, from 2018 onward, there has been an increase in research using the zebrafish model and bioactive compounds, highlighting the field of Pharmacy/Pharmacology in the development of new drugs, with a strong emphasis on the use of medicinal plants.
    Keywords:  Danio Rerio; Natural products; Plants; Secondary metabolites
    DOI:  https://doi.org/10.1007/s40203-025-00363-z
  41. Drug Des Devel Ther. 2025 ;19 3805-3825
    A Bibliometric Analysis of Microneedle-Mediated Drug Delivery: Trends, Hotspots, and Future Directions.
    Weiyi Xiang, Xian Jiang, Linghong Guo.
       Purpose: Microneedles can physically penetrate the stratum corneum, creating micropores on the skin, and allowing for drug delivery through direct diffusion, injection, or other methods. As a novel drug delivery method, it possesses significant application potential. This study uses bibliometric analysis to explore the research hotspots and development trends of microneedle-mediated drug delivery.
    Methods: Relevant research articles on microneedle-mediated drug delivery published between 1998 and 2024 in the Web of Science Core Collection (WoSCC) database were retrieved. Data analysis and visualization were performed using VOSviewer, CiteSpace, Scimago Graphica, and Pajek, enabling the prediction of research trends in microneedle-mediated drug delivery.
    Results: In general, research on microneedle-mediated drug delivery has shown a continuous increase. China and the United States are the leading countries in this field of study. Notably, Ryan F. Donnelly (n=224) is the most prominent contributor to this field. The current core research directions include: disease treatment, enhancement of transdermal absorption performance of microneedles, vaccine delivery, and new materials and technologies for microneedle manufacturing.
    Conclusion: Microneedle-mediated drug delivery, as a novel technology and method, holds significant research value and application potential. However, further strengthening of international collaboration and the clinical translation of research findings are needed.
    Keywords:  materials science; percutaneous drug delivery; research trends; vaccine delivery
    DOI:  https://doi.org/10.2147/DDDT.S519048
  42. Discov Oncol. 2025 May 14. 16(1): 765
    Photodynamic therapy in esophageal cancer: trends, innovations, and future directions from a global perspective (1985-2024).
    Yao-Xuan Chen, Feng Guo, Hao-Han Rao, Chong-Qi Fan, Chun-Jian Zuo, Peng-Yu Che, Cao Yu, Huan-Wen Chen.
       BACKGROUND: Esophageal cancer (EC) is a leading cause of cancer-related deaths worldwide. Photodynamic therapy (PDT) has emerged as a promising, minimally invasive treatment for EC due to its high selectivity. However, a comprehensive bibliometric analysis of PDT in EC is lacking. This study aims to assess research trends, key contributors, and emerging themes in PDT for EC from 1985 to 2024.
    METHODS: We performed a bibliometric analysis using data from the Web of Science Core Collection. VOSviewer, CiteSpace, and the R package 'bibliometrix' were employed to examine publication trends, collaboration networks, and primary research themes related to PDT in EC.
    RESULTS: The analysis included 581 publications by 2037 researchers from 593 institutions across 40 countries. The United States, China, and England were the top contributors, with significant input from the Mayo Clinic and Thompson Cancer Survival Center. Photodiagnosis and Photodynamic Therapy was the most prolific journal, while Gastrointestinal Endoscopy received the highest citations. Research areas covered various aspects of PDT in EC, including its combination with endoscopic treatments, use of photosensitizers, palliative care applications, biological mechanisms, and nanoparticle drug delivery advancements. Emerging themes highlighted the application of nanotechnology in drug delivery, integration of immunotherapy, and exploration of the tumor microenvironment.
    CONCLUSION: This bibliometric study reveals a global expansion in PDT research for EC, emphasizing new directions such as nanotechnology-enhanced drug delivery, immunotherapy integration, and tumor microenvironment studies. These advancements are expected to improve PDT's effectiveness, particularly in overcoming the limitations of current treatments for deeper and more advanced EC cases.
    Keywords:  Bibliometric analysis; Esophageal cancer; Integration therapy; Nanotechnology; Photodynamic therapy; Tumor microenvironment
    DOI:  https://doi.org/10.1007/s12672-025-02643-8
  43. Front Pediatr. 2025 ;13 1468788
    A bibliometric analysis of metabolic dysfunction-associated steatotic liver disease in children from 2004 to 2024.
    Xiaowei Gong, Siyu Bai, Enze Lei, Tao Lu, Yao Chen, Jianxin Cai, Jianzhong Liu.
       Background: Metabolic dysfunction-associated steatotic liver disease (MASLD), once known as Non-alcoholic fatty liver disease, impacts between 3% and 10% of children and adolescents globally, as well as nearly one-third of obsessed boys and one-quarter of obsessed girls, and is the most frequent cause of pediatric liver disease associated with the obesity epidemic. With the growing attention and increasing volume of literature on pediatric MASLD, there is an urgent need for bibliometric analysis and visualization in the area of pediatric MASLD study in terms of dissecting study priorities.
    Methods: Literature was searched in the Web of Science Core Collection database, followed by categorization, bibliometric study as well as visual analysis conducted by applying software including Citespace, VOSviewer, and the R language. The study concentrated on analyzing information related to key authors, spatial and temporal distribution, core keywords, and important citations.
    Results: In total, 3,409 publications on pediatric MASLD were collected in the study, including 2,697 articles and 712 review articles. Between 2004 and 2024, the volume of publications had been constantly increasing per year. The country with the most numerous publications was the United States, which had extensive exchanges and collaborations with Italy, China, and England, followed by Italy. The Journal of Pediatric Gastroenterology and Nutrition had the greatest quantity of publications in this domain. The core literature was a clinical guideline. Insulin resistance, metabolic syndrome, steatohepatitis, hepatocellular carcinoma, cardiovascular risk, diabetes risk, diagnostic accuracy, lifestyle intervention, gut microbiome, probiotics, and metabolic dysfunction-associated steatotic liver disease were also hot topics and frontier trends in pediatric MASLD studies.
    Conclusion: This research represents the inaugural application of bibliometric analysis to examine the developmental trajectory of pediatric MASLD studies over the past two decades, which reveals that the etiology, pathological changes of the liver, relationship with obesity, complications, comorbidities, diagnosis and treatments of pediatric MASLD are the key focuses and provides academic references for pediatric clinicians and scholars to grasp the hotspots, the cutting edge and the evolving trends in the area.
    Keywords:  CiteSpace; VOSviewer; bibliometric; children; metabolic dysfunction-associated steatotic liver disease; visual analysis
    DOI:  https://doi.org/10.3389/fped.2025.1468788
  44. Front Neurol. 2025 ;16 1539736
    A bibliometric analysis of electroencephalogram research in stroke: current trends and future directions.
    Xiao-Yu Liao, Yu-Er Jiang, Ren-Jie Xu, Ting-Ting Qian, Shi-Lu Liu, Yi Che.
       Background: Electroencephalography (EEG) has become an indispensable tool in stroke research for real-time monitoring of neural activity, prognosis prediction, and rehabilitation support. In recent decades, EEG applications in stroke research have expanded, particularly in areas like brain-computer interfaces (BCI) and neurofeedback for motor recovery. However, a comprehensive analysis of research trends in this domain is currently unavailable.
    Methods: The study collected data from the Web of Science Core Collection database, selecting publications related to stroke and EEG from 2005 to 2024. Visual analysis tools such as VOSviewer and CiteSpace were utilized to build knowledge maps of the research field, analyzing the distribution of publications, authors, institutions, journals, and collaboration networks. Additionally, co-occurrence, clustering, and burst detection of keywords were analyzed in detail.
    Results: A total of 2,931 publications were identified, indicating a consistent increase in EEG research in stroke, with significant growth post-2017. The United States, China, and Germany emerged as the leading contributors, with high collaboration networks among Western institutions. Key research areas included signal processing advancements, EEG applications in seizure risk and consciousness disorder assessment, and EEG-driven rehabilitation techniques. Notably, recent studies have focused on integrating EEG with machine learning and multimodal data for more precise functional evaluations.
    Conclusion: The findings reveal that EEG has evolved from a diagnostic tool to a therapeutic support platform in the context of stroke care. The advent of deep learning and multimodal integration has positioned EEG for expanded applications in personalized rehabilitation. It is recommended that future studies prioritize interdisciplinary collaboration and standardized EEG methodologies in order to facilitate clinical adoption and enhance translational potential in stroke management.
    Keywords:  CiteSpace; VOSviewer; bibliometrix; electroencephalogram; stroke; visualization analysis
    DOI:  https://doi.org/10.3389/fneur.2025.1539736
  45. J Robot Surg. 2025 May 16. 19(1): 219
    Scientific evolution of robotic surgery in urogenital diseases: bibliometric analysis.
    Camilo Andrés Giedelman Cuevas, Gonzalo Andrés Domínguez Alvarado, Claudia Jaimes González, Carlos Felipe Palomino Peña, Luis Eduardo Cavelier Castro.
      Robotic surgery has revolutionized modern medicine, particularly in urology, by enhancing surgical precision through advanced visualization, motion scaling, and tremor filtration. As a result, robotic-assisted surgery has become the standard of care for complex procedures, such as radical prostatectomy, with demonstrated benefits in reducing complications and improving clinical outcomes. Despite the rapid evolution of this field, no comprehensive bibliometric analysis has systematically evaluated its scientific trajectory, research trends, and international collaboration. A cross-sectional bibliometric study was conducted using Scopus as the primary data source. A semi-structured search strategy incorporating MeSH terms and synonyms was applied to identify publications related to robotic surgery in urogenital diseases. Data were exported, standardized, and analyzed using Bibliometrix (R 4.3.1) for bibliometric and network analyses. A total of 3506 publications (1993-2024) were included, with 79.2% original articles and 11.6% reviews. The United States (n = 1388) led the scientific production, followed by Italy (n = 389) and Japan (n = 285). The research predominantly focused on prostate tumors, clinical outcomes, and surgical complications, while recent trends highlighted growing interest in robot-assisted total cystectomy. The exponential growth of robotic surgery research aligns with its increasing clinical adoption. However, regional disparities persist, emphasizing the need to expand scientific contributions from high-volume surgical centers. Promoting global research collaboration will further consolidate robotic surgery as a fundamental tool in urological practice.
    Keywords:  Bibliometrics; Biomedical research; Robotic surgery; Robotic surgical procedures; Urogenital diseases
    DOI:  https://doi.org/10.1007/s11701-025-02359-5
  46. Front Med (Lausanne). 2025 ;12 1541364
    Trends and hotspots in pulmonary fibrosis biomarker research: a bibliometric analysis.
    Ling Wang, Jianliang Huang, Gan Tan, Yurou Zhang, Mingkai Xia, Zhen Kang, Yun Xiao, Mingsheng Lei.
       Background: Pulmonary fibrosis is a fatal disease characterized by progressive scarring of lung tissue, with a complex pathogenesis and limited therapeutic options. The identification of robust biomarkers is critical for addressing key clinical challenges, including delayed diagnosis and poor prognostic assessment.
    Methods: This study systematically analyzes global research trends and emerging hotspots in pulmonary fibrosis biomarkers by examining literature from 2001 to 2024 indexed in the Web of Science Core Collection. Utilizing a suite of bibliometric tools including VOSviewer, CiteSpace, Bibliometrix, Scimago Graphica, and OriginPro 2021, this work provides the first comprehensive insight into the evolving landscape of biomarker research in pulmonary fibrosis.
    Results: This study included a total of 2,519 articles and reviews related to pulmonary fibrosis biomarkers. Since 2005, publication trends in this field have steadily increased. Research on pulmonary fibrosis biomarkers has involved 71 countries, 3,036 institutions, 760 journals, and over 14,000 researchers. China produced the highest number of publications (n = 535, 21.2%, TLCS = 459), followed by the United States (n = 529, 21%, TLCS = 3,527) and Japan (n = 270, 10.7%, TLCS = 1,279), with the United States exerting the greatest influence. The UNIVERSITY OF CALIFORNIA SYSTEM (n = 164) and HARVARD UNIVERSITY (n = 141) contributed the largest bodies of work. The most prolific authors in this domain are BARGAGLI E (n = 45), MAHER TM (n = 42), and MARTINEZ FJ (n = 32). The AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE is widely regarded as the leading journal in this field. In recent years, research has increasingly focused on macrophages, computed tomography, and Muc5b promoter polymorphism, among other areas. The concept of "double blind" reflects the translational trend of biomarkers toward clinical applications, particularly their potential utility in acute exacerbations of pulmonary fibrosis, interstitial pulmonary fibrosis, cystic pulmonary fibrosis, and radiation-induced pulmonary fibrosis.
    Conclusion: The clinical application of gene and imaging biomarkers achieved through the integration of multiple parameters and multi-omics fusion represents a promising future trend and emerging hotspot in pulmonary fibrosis biomarker research.
    Keywords:  MUC5B; bibliometric analysis; biomarkers; disease management; pulmonary fibrosis
    DOI:  https://doi.org/10.3389/fmed.2025.1541364
  47. Front Immunol. 2025 ;16 1519321
    Unveiling research hotspots: a bibliometric study on macrophages in musculoskeletal diseases.
    Yaohang Yue, Siyang Cao, Fuyang Cao, Yihao Wei, Aikang Li, Deli Wang, Peng Liu, Hui Zeng, Jianjing Lin.
      Research on the role of macrophages in musculoskeletal (MSK) diseases has significantly increased in recent years. However, a thorough evaluation of the developmental trajectory of this field, including the contributions of prominent authors and primary research themes, remains insufficient. Furthermore, the identification of emerging research hotspots requires more detailed exploration. This study collated articles and reviews addressing "macrophages in MSK diseases" published between 2004 and 2023, with all data extracted from the Web of Science database. The collected data were analyzed using a variety of bibliometric and visualization tools, such as VOSviewer, CiteSpace, GraphPad Prism, and R packages. Results indicate that China and the United States are the leading contributors in this research domain. Among the many academic institutions involved, Shanghai Jiao Tong University and the University of California stand out as the most productive. The journal "Frontiers in Immunology" had the highest publication output on this topic. The five most frequently explored research domains include Immunology, Rheumatology, Pharmacology and Pharmacy, Cell Biology, and Biochemistry and Molecular Biology. These results offer a comprehensive overview of the current state of research in this field and provide meaningful insights for guiding future studies.
    Keywords:  bibliometrics; data visualization; macrophage; musculoskeletal diseases; orthopaedics
    DOI:  https://doi.org/10.3389/fimmu.2025.1519321
  48. Jamba. 2025 ;17(1): 1776
    Leveraging artificial intelligence in disaster management: A comprehensive bibliometric review.
    Arief Wibowo, Ikhwan Amri, Asep Surahmat, Rusdah Rusdah.
      The advancement of artificial intelligence (AI) technology presents promising opportunities to improve disaster management's effectiveness and efficiency, particularly with the rising risk of natural hazards globally. This study used the Scopus database to offer a bibliometric review of AI applications in disaster management. Publications were chosen based on research scope (natural hazards), source type (journals and conference proceedings), document type (articles, conference papers and reviews) and language (English). VOSviewer and Biblioshiny were utilised to analyse trends and scientific mapping from 848 publications. The finding shows a rapid increase in AI studies for disaster management, with an annual growth rate of 15.61%. The leading source was the International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences - ISPRS Archives. Amir Mosavi was the most prolific author, with 10 documents. The analysis reveals that China was the most productive country, while the United States was the most cited. Six research clusters were identified through keyword network mapping: (1) disaster monitoring and prediction using IoT networks, (2) AI-based geospatial technology for risk management, (3) decision support systems for disaster emergency management, (4) social media analysis for emergency response, (5) machine learning algorithms for disaster risk reduction, and (6) big data and deep learning for disaster management.
    Contribution: This research contributes by mapping the application of AI technology in disaster management based on peer-reviewed literature. This helps identify major developments, research hotspots, and gaps.
    Keywords:  Scopus; artificial intelligence; bibliometric analysis; disaster management; natural hazard
    DOI:  https://doi.org/10.4102/jamba.v17i1.1776
  49. Discov Oncol. 2025 May 13. 16(1): 755
    Machine learning in ovarian cancer: a bibliometric and visual analysis from 2004 to 2024.
    Xian Zeng, Zude Li, Lilin Dai, Jiang Li, Luqin Liao, Wei Chen.
       OBJECTIVE: Ovarian cancer (OC) is a common malignant tumor in women, with poor prognosis and high mortality rates. Early diagnosis, screening, and prognostic prediction of OC have long been focal points and challenges in this field. In recent years, machine learning (ML) has gradually demonstrated its unique advantages in the early diagnosis, screening, and prognostic prediction of tumors, including OC.This study aims to analyze global development trends and research hotspots in the application of ML for OC, thereby providing a reference for future research directions.
    METHODS: We searched the Web of Science Core Collection (WoSCC) for all publications related to OC and ML from 2004 to 2024, conducting a quantitative analysis using VOSviewer, R software, and CiteSpace.
    RESULTS: A total of 777 articles were retrieved.The number of publications related to ML and OC has grown continuously over the past 20 years.China led with 254 articles.The most prominent journals include Gynecologic Oncology, Nature, Clinical Cancer Research, Cancer Research, and Journal of Clinical Oncology.Research hotspots are: (a) ML-driven OC biomarker discovery and personalized treatment; (b) ML in tumor microenvironment analysis and resistance prediction; (c) ML in imaging-based diagnosis and risk stratification; (d) ML in multicenter OC studies.
    CONCLUSION: ML in OC is currently in a developmental phase and shows promising potential for the future. This study provides researchers and clinicians with a more systematic understanding of research priorities and forthcoming developments in this area.
    Keywords:  Artificial intelligence; Bibliometrics; Deep learning; Machine learning; Ovarian cancer
    DOI:  https://doi.org/10.1007/s12672-025-02416-3
  50. Cureus. 2025 Apr;17(4): e82058
    A Bibliometric Review of Actigraphy-Based Sleep Research in Diabetes.
    Ayesha Juhi, Himel Mondal.
      Actigraphy is a valuable tool for objectively assessing sleep patterns, with growing interest in its application to sleep research in patients with diabetes mellitus. Sleep disturbances are increasingly recognized as modifiable risk factors for metabolic dysregulation, yet the research landscape in this domain remains unclear. This bibliometric analysis aimed to evaluate global research trends, influential contributors, and thematic developments in actigraphy, sleep, and diabetes. Data were retrieved from PubMed, covering the period from 2005 to 2024, and analyzed using Biblioshiny and VOSviewer to assess publication growth, collaboration networks, keyword co-occurrence, and thematic evolution. A total of 203 publications from 101 sources were identified, with an annual growth rate of 18.11%, indicating rising research interest. Contributions from 1,170 authors demonstrated strong collaboration, with 10.84% of studies involving international co-authorship. Core journals, including SLEEP, SLEEP MEDICINE, and JOURNAL OF SLEEP RESEARCH, played a dominant role, while institutions such as Kyoto University and the University of Illinois at Chicago emerged as leading research hubs. Thematic analysis revealed a transition from foundational studies on glucose metabolism and polysomnography to investigations of circadian rhythms, actigraphy-based sleep monitoring, and metabolic health. Recent trends highlight emerging topics such as gestational diabetes and mental health, signaling shifting research priorities. While collaboration networks indicate strong regional clusters, greater international partnerships are needed to improve research diversity and applicability. This study highlights the expanding role of actigraphy in sleep and diabetes research, with implications for adaptive medicine, artificial intelligence-driven sleep analytics, and digital health interventions.
    Keywords:  actigraphy; bibliometric analysis; circadian rhythm; diabetes; glucose monitoring; insulin resistance; metabolic health; sleep; sleep disorders; wearable technology
    DOI:  https://doi.org/10.7759/cureus.82058
  51. Front Neurosci. 2025 ;19 1595253
    The developments and emerging trends of Autonomic Nervous System Research in Arrhythmia: a bibliometric study from 2004 to 2024.
    Tingting Chen, Yanfeng Yang, Kun Shi, Feifei Si, Yizhou Wen, Xiao Yang.
      The role of the autonomic nervous system in cardiovascular diseases has increasingly attracted the attention of researchers. This study aims to review research on the autonomic nervous system in arrhythmias from 2004 to 2024, with a focus on understanding the development trends in this field. Data for this study were sourced from the Web of Science Core Collection. We constructed and analyzed bibliometric visualizations related to publication trends, countries/regions, institutions, journals, research categories, themes, references, and keywords. Over the past two decades, academic output related to the autonomic nervous system's role in arrhythmias has grown, although global research distribution remains uneven. The United States leads in publication volume and is home to many high-output institutions, providing it with significant academic influence and fostering international collaboration. By summarizing high-citation literature, clustering keywords, and performing a "burst detection" analysis of keywords, we identified that the mechanisms and assessment methods for autonomic nervous system regulation are major research focuses. Recent hotspots include the psychopathology related to the autonomic nervous system and autonomic regulation therapies. As the biomedical field shifts toward precision medicine, future research trends are likely to focus on identifying precise biomarkers for assessing autonomic nervous system function and developing novel strategies to regulate it. These strategies may include correcting immune dysfunction, psychological interventions, and surgical treatments. This study suggests that ganglionated plexi ablation may represent the most transformative intervention strategy for the Autonomic Nervous System currently available, and highlights electrodermal activity as an evaluation index with considerable potential for widespread application.
    Keywords:  arrhythmia; autonomic nervous system; bibliometric; development; emerging trends
    DOI:  https://doi.org/10.3389/fnins.2025.1595253
  52. J Orthop Res. 2025 May 10.
    Analysis of Article Processing Charges of Orthopaedic Journals in the United States.
    Allyson N Pfeil, Zachary Rickmeyer, Joshua H Taylor, Davin K Fertitta, Anay R Patel, T Bradley Edwards, Corey F Hryc.
      In the United States, article processing charges for orthopaedic journals can be excessive and may offer a poor cost-to-benefit ratio regarding article engagement. This study hypothesizes that article processing charges will not strongly correlate with metrics of engagement such as citations, regardless of publication model. The Journal Citation Reports (Clarivate, Philadelphia, PA) identified 136 orthopaedic journals, of which 83 were non-United States journals and six were not suitable for analysis, resulting in 47 journals for analysis. The collected variables included access options, article processing charge, publisher, impact factor with and without self-citations, immediacy index, normalized Eigenfactor (journal influence), article influence score, total citations, total articles, citations per open access article, and citations per restricted and free article. T- and Chi-square tests statistically compared continuous and categorical variables, respectively, and significance was determined at p < 0.05. Linear regressions computed a coefficient of determination to assess any correlation between cost and metrics of engagement, with strong correlation assessed at ≥ 0.80. Publishing unrestricted open access was significantly more expensive in hybrid journals. Hybrid journals received significantly more total citations than open access, however, no difference between hybrid or open access journals was noted when comparing citations per article within 3 years. No other differences or correlations were found in engagement metrics, publication models, or cost. Access and incorporation of novel findings into clinical practice may depend on scientific publishing practices and, specifically, our ability to maximize viewership while maintaining cost-effectiveness.
    Keywords:  article processing charges; orthopaedic publication price; orthopaedic research; publication costs
    DOI:  https://doi.org/10.1002/jor.26097
  53. Narra J. 2025 Apr;5(1): e1372
    Research trends in microRNA profiling as a biomarker for lung adenocarcinoma via liquid biopsy: A bibliometric analysis.
    Aprilia I Kartika, Muchamad Dafip, Nastiti Wijayanti, Didik S Heriyanto, Sofia M Haryana, Kartika W Taroeno-Hariadi.
      Research related to the development of diagnostic biomarkers in lung adenocarcinoma in various countries is important. Research on microRNA as a biomarker in lung adenocarcinoma varies depending on the population, specimen, and technology used for profiling and validation. The aim of this study was to map and analyze bibliometric data of publications related to the topic of microRNA as a candidate biomarker in lung adenocarcinoma and to determine any potential research gaps. A total of 8,506 articles were collected from Crossref, Google Scholar, Semantic Scholar, PubMed, and Scopus databases using Harzing's Publish or Perish platform. A systematic search was conducted using four keywords: "profiling," "validating," "microRNA," and "lung adenocarcinoma," and synonyms of these keywords based on the MeSH on NCBI. The data extraction process followed the chart from PRISMA-P. The article's elimination was conducted using Mendeley Desktop and then was analyzed based on the authors' keywords using VOSviewer and Biblioshiny. A bibliometric analysis of 692 relevant articles identified four primary research clusters: (1) microRNA (19 keywords), which highlights its potential as a biomarker for early detection and diagnosis; (2) lung adenocarcinoma (18 keywords), reflecting advancements in lung cancer research; (3) liquid biopsy (19 keywords), emphasizing the growing interest in non-invasive diagnostic methods; and (4) bioinformatics (nine keywords), underscoring the role of computational approaches in transcriptomic analysis. As a primary topic, microRNAs have become a focal point of research for diagnosing lung cancer across various stages and as biomarkers for cancer cell proliferation, invasion, migration, and metastasis. Numerous studies have demonstrated the successful application of microRNAs in lung cancer diagnosis in the last decade, although the reported types of microRNAs are inconsistent. Therefore, further research on this topic should be continuously conducted, particularly to validate the types of microRNAs and the types of environments that influence them.
    Keywords:  Bibliometric; VOSviewer; liquid biopsy; lung adenocarcinoma; microRNA
    DOI:  https://doi.org/10.52225/narra.v5i1.1372
  54. Curr Neuropharmacol. 2025 May 13.
    The Evolution of Machine Learning in Medicinal Chemistry: A Comprehensive Bibliometric Analysis.
    Yanhua Wang, Tongxin Guan, Dongyu Xu, Mingyan Liu, Zhichang Zhang.
       INTRODUCTION: In the medicinal chemistry (MC) field, artificial intelligence (AI) has been used to establish quantitative structure-activity relationship (QSAR) classification models, virtual screening, drug discovery, drug design, and so on. In this investigation, MC AI studies (AI-MC) (from 2001-2023) underwent quantitative and qualitative modeling analyses.
    METHODS: Using a hybrid research strategy incorporating content analyses and bibliometric methods, we retrospectively analysed the AI-MC literature using a bibliometrix package (R software) combined with CiteSpace V and VOSviewer programs.
    RESULTS: Between 2001 and 2023, AI-MC articles were published in 92 countries or regions, with China and the United States leading in the number of publications. Also, 196 affiliations were added to AI-MC research; the CHINESE ACADEMY OF SCIENCES contributed the most. Reference clusters were categorized as follows: (1) QSAR, (2) virtual screening, (3) drug discovery, (4) drug design. Predictive model(2020-2021), molecular fingerprints (2021-2023) and scoring function (2021-2023) reflected research frontier keywords. As we look to the future, the ongoing progress and innovation in technology herald the promising development of multimodal and large language models (LLMs) within the realm of MC.
    CONCLUSIONS: We comprehensively characterized the AI-MC field and determined future trends and hotspots. Importantly, we provided a dynamic oversight of the AI-MC literature and identified key upcoming research areas.
    Keywords:  Artificial intelligence; bibliometrics; deep learning; machine learning; medicinal chemistry.
    DOI:  https://doi.org/10.2174/011570159X384988250430093924
  55. Braz Oral Res. 2025 ;pii: S1806-83242025000101553. [Epub ahead of print]39 e052
    Shedding light on Brazil's contribution to photobiomodulation research in oral medicine: a bibliometric study.
    Lauren Frenzel Schuch, Laura Borges Kirschnick, Vivian Petersen Wagner, Vanessa Rodrigues Velho, Gabriela Sauer Llantada, Marco Antonio Trevizani Martins, Márcia Martins Marques, Antonio Luiz Barbosa Pinheiro, Jean Nunes Dos Santos, Alan Roger Santos-Silva, Cesar Augusto Migliorati, Manoela Domingues Martins.
      The aim of this study was to verify the role of Brazilian researchers in publications related to photobiomodulation (PBM) in the field of oral medicine. We examined ten years from 2012 to 2022 across 16 journals. Our analysis included scientific publications with a Brazilian author either in the first or last position and publications from international collaborations. The search yielded 43,525 publications. After examining titles and abstracts, 269 studies were categorized as having a specific emphasis on PBM in oral medicine, of which 147 (54.6%) were undertaken by research groups based in Brazil. The citations ranged from 1 to 149 (an average of 31 per manuscript). The male-to-female ratio of first and last author was 1:2 and 1:1.4, respectively. Brazilian involvement in the field of PBM was significant, with a marked focus on basic research, clinical applications, and technological advances. Our results also underscore the remarkable participation of female researchers in pivotal roles. Brazilian publications positively impacted healthcare worldwide using PBM in oral medicine, as evidenced by the substantial number of articles published and the citations of these articles received.
    DOI:  https://doi.org/10.1590/1807-3107bor-2025.vol39.052
  56. R Soc Open Sci. 2025 May;12(5): 250263
    A decade of vertebrate palaeontology research: global taxa distribution, gender dynamics and evolving methodologies.
    Haohan Wang, Juliana Sterli, Vincent Dupret, Henning Blom, Annalisa Berta, Susan Turner, Daoming Han, Luyan Xu, Zhaohui Pan.
      Using 12 104 publications from 2014 to 2023 in the DeepBone database, this study employs bibliometric methods, including full-text latent Dirichlet allocation (LDA) modelling, co-occurrence network analysis and geographic mapping with ArcGIS, to examine three key aspects of vertebrate palaeontology development: geographic distribution of newly established taxa, gender demographics among researchers and research trends. Gender data were analysed using automated tools with manual verification to ensure accuracy, while methodological evolution was investigated through systematic text mining and classification. Among 8336 newly established taxa, mammals (34.72%) and fishes (29.76%) dominate, followed by reptiles (25.34%), birds (7.39%) and amphibians (2.80%). Geographic analysis reveals significant regional disparities, with the USA (13.50%) and China (13.32%) contributing the most, while Africa and Oceania remain under-represented (less than 10%). Gender analysis indicates a gradual increase in female representation from 22.78 to 27.20% over the decade, highlighting the imperative to address gender disparities in vertebrate palaeontology, thereby advancing equity in alignment with UNESCO Sustainable Development Goal 5. LDA topic modelling identifies 15 distinct research topics, encompassing evolutionary biology, cranial and skeletal morphology, dinosaur-bird evolution and human evolution, while co-occurrence analysis highlights the evolution of research methodologies, revealing strong interconnections between phylogenetic analysis (15%), traditional morphological analysis (12%) and high-resolution imaging techniques (9%).
    Keywords:  bibliometric analysis; gender gap; latent Dirichlet allocation topic modelling; methodological evolution; vertebrate palaeontology
    DOI:  https://doi.org/10.1098/rsos.250263
  57. Discov Nano. 2025 May 12. 20(1): 78
    Feasibility analysis and development trend of nanomaterials for the treatment of pancreatic cancer.
    Jingyao Zhu, Yue Li, Xiaoqing Li, Yong Wang, Qixiang Liu, Yang Yang, HongJian Guan.
      Pancreatic cancer is a highly aggressive disease that poses a significant threat to human health. Although conventional chemotherapy remains an effective treatment, it is often associated with severe side effects, underscoring the need for more effective cancer therapies. In this study, we analyzed the keywords of past studies, the countries with the highest number of publications, the leading journals, prominent authors, and collaborations between countries, authors, and journals, as well as the impact factors of relevant literature. The aim was to explore the trends in the use of nanomaterials for the treatment of pancreatic cancer, enabling researchers to review past achievements and gain a better understanding of future research directions. Relevant research articles were sourced from core Web of Science databases, and VOSviewer and CiteSpace visualization tools were employed to reveal the intrinsic links between the information. Research on the use of nanomaterials for the therapy of pancreatic cancer has been growing since the twenty-first century, particularly from 2018 to the present. The United States has become a leader in this field, with the highest number of publications and the most published authors. Additionally, a 2018 study published in Nature demonstrated that patients with insufficient CD8 + T-cell infiltration in the pancreatic cancer tumor microenvironment (TME) had significantly lower survival rates (HR = 2.5, p < 0.001). And CSF1R inhibitors combined with a PD-1 antibody resulted in 60% tumor shrinkage in a mouse model. These findings suggest that research on the tumor microenvironment and immunotherapy is poised to be a key focus of future studies, offering new hope for pancreatic cancer patients.
    Keywords:  Future research trends; Nanomaterials; Pancreatic cancer; Past hotspot; Visual analysis
    DOI:  https://doi.org/10.1186/s11671-025-04259-x
  58. Front Med (Lausanne). 2025 ;12 1546611
    International visualization analysis of research hotspots and development trends in the study of clinical decision support systems utilizing CiteSpace.
    Meixuan Song, Dong Liu.
       Objective: This study aims to elucidate the current status and trends in clinical decision support systems (CDSS). It will analyze the direction of research development in this field and provide valuable references for future research and the application of CDSS.
    Methods: We conducted a search of the Web of Science Core Collection database from January 2014 to May 2024 to identify relevant literature on clinical decision support systems. CiteSpace (6.2. R4) software was utilized to visualize and analyze various aspects of the included literature, including publication volume, country of origin, authors, institutions, cited literature, keywords, and keyword clustering, and to generate corresponding graphs.
    Results: A total of 2,668 articles were ultimately included in this study. The scholar with the highest number of publications is Professor Adam from the Department of Biomedical Information at Vanderbilt University in the United States. The top five countries contributing to this research are the United States, the United Kingdom, Germany, the Netherlands, and China. Based on an analysis of cited literature and keyword clustering, the research primarily focuses on predicting biochemical recurrence, cardiovascular disease, clinical guidelines, evidence-based computerized decision support systems, and intensive care units. The prominent topics in this field include artificial intelligence, natural language processing, venous thromboembolism, user-centered design, and emergency medicine.
    Conclusion: Research on CDSS is demonstrating an upward trend and shows promising development prospects. Artificial intelligence, natural language processing, and user-centered design are the future trends.
    Keywords:  CiteSpace; clinical decision support system; development trends; hotspots; visual analysis
    DOI:  https://doi.org/10.3389/fmed.2025.1546611
  59. J Am Acad Orthop Surg Glob Res Rev. 2025 May 01. 9(5):
    Orthopaedic Authorship: Sex-Based Resident Publication Trends.
    Chloe K Herczeg, Santiago Aragon, Mia V Rumps, Mary K Mulcahey.
       INTRODUCTION: Orthopaedic surgery is a historically male-dominated specialty. The purpose of this study was to analyze sex-specific, educational, geographic, and publication trends of orthopaedic surgery residents to quantify female representation in training and academia.
    METHODS: Demographic information was collected from accredited orthopaedic surgery residency websites. Schools and programs were ranked by the Doximity Residency Navigator and US News & World Report evaluations. Publications metrics were searched in PubMed and Scopus.
    RESULTS: Three thousand three hundred forty-five orthopaedic surgery residents were identified on residency websites, and 2,736 (81.8%) male and 609 (18.2%) female residents. Female residents more often attended top 20 residency programs (28.6% vs. 19.2%, P = 0.00000026), top 50 research medical schools (45.7% vs. 34.8%, P = 0.0000036), and residencies affiliated with top 20 research schools (19.0% vs. 14.1%, P = 0.0026). Female residents authored 1,740 publications (16.4%), whereas male residents authored 8,801 (82.9%). No difference was observed in H-indices, median interquartile range by training year, authorship position, publications in top journals, or research output.
    CONCLUSION: Although female orthopaedic surgery residents were more likely to be affiliated with higher-ranking educational institutions, this had no clear influence on research productivity, as suggested by comparable median interquartile ranges and H-indices. Future studies should explore whether research productivity has evolved over time and, if so, how.
    DOI:  https://doi.org/e24.00261
  60. JB JS Open Access. 2025 Apr-Jun;10(2):pii: e24.00224. [Epub ahead of print]10(2):
    Uneven Ground: Exploring the Impact of Geographical Region and Gender on Orthopaedic Surgery Resident Research Productivity.
    Natasja Lessiohadi, Hayden Hartman, James Pai, William B Goodman, Mia V Rumps, Mary K Mulcahey.
       Introduction: Research plays a crucial role in orthopaedic surgery advancement, patient outcomes, and both residency and fellowship training. This study aimed to examine associations between research productivity of orthopaedic surgery residents, gender proportion of residents, and the geographical region of orthopaedic surgery residency programs.
    Methods: Using the Fellowship and Residency Electronic Interactive Database (FRIEDA) and the Doximity Residency Navigator, a list of the top 10 Accreditation Council for Graduate Medical Education (ACGME) orthopaedic surgery residency programs for each region (Northeast, South, Midwest, and West) were identified. FRIEDA, program websites, SCOPUS, PubMed, and ResearchGate were utilized to collect the following: residency program name, type, and location; and resident name, gender, H-index, and number of publications.
    Results: Forty orthopaedic surgery residency programs and 1,377 residents across 4 regions were evaluated. Of these, 29.6% (408/1,377) were female and 70.4% (969/1,377) were male. Northeast programs averaged the highest publications (11.6) per resident, while the South averaged the fewest publications (5.9, p < 0.0001). Similarly, residents in Northeast programs had the highest average H-index (2.9), and residents in the South had the lowest average H-index (1.6) (f-ratio = 11.19, p < 0.0001). Male residents averaged more publications (9.0 vs. 5.5, p < 0.05) and higher H-indices (2.3 vs. 1.8, p < 0.05) than female residents. These differences were greatest in the South (male:female publication ratio = 1.9, H-index ratio = 1.4) and lowest in the Midwest (male:female publication ratio = 1.3, H-index ratio = 1.1).
    Conclusion: At the top 10 orthopaedic surgery residency programs across all regions, female residents remain underrepresented in academic research compared with male residents, evidenced by a lower average number of publications H-indices, with the degrees of these discrepancies varying regionally. Further research is needed to identify the underlying factors influencing these differences. Program directors and orthopaedic surgery residents should be aware of these geographic and gender-based trends to improve their academic productivity and address the existing inequities within academic orthopaedics.
    Level of Evidence: Level IV. See Instructions for Authors for a complete description of levels of evidence.
    DOI:  https://doi.org/10.2106/JBJS.OA.24.00224
  61. Elife. 2025 May 14. pii: RP88540. [Epub ahead of print]12
    Trends in self-citation rates in high-impact neurology, neuroscience, and psychiatry journals.
    Matthew Rosenblatt, Saloni Mehta, Hannah Peterson, Javid Dadashkarimi, Raimundo Rodriguez, Maya L Foster, Brendan D Adkinson, Qinghao Liang, Violet M Kimble, Jean Ye, Marie C McCusker, Michael C Farruggia, Max J Rolison, Margaret L Westwater, Rongtao Jiang, Stephanie Noble, Dustin Scheinost.
      Citation metrics influence academic reputation and career trajectories. Recent works have highlighted flaws in citation practices in the Neurosciences, such as the under-citation of women. However, self-citation rates-or how much authors cite themselves-have not yet been comprehensively investigated in the Neurosciences. This work characterizes self-citation rates in basic, translational, and clinical Neuroscience literature by collating 100,347 articles from 63 journals between the years 2000-2020. In analyzing over five million citations, we demonstrate four key findings: (1) increasing self-citation rates of Last Authors relative to First Authors, (2) lower self-citation rates in low- and middle-income countries, (3) gender differences in self-citation stemming from differences in the number of previously published papers, and (4) variations in self-citation rates by field. Our characterization of self-citation provides insight into citation practices that shape the perceived influence of authors in the Neurosciences, which in turn may impact what type of scientific research is done and who gets the opportunity to do it.
    Keywords:  bibliometrics; neurology; neuroscience; none; psychiatry; self-citation
    DOI:  https://doi.org/10.7554/eLife.88540
  62. Cancer Prev Res (Phila). 2025 Apr 01. 18(4): 177
    Editors' Selections from Relevant Scientific Publications.
      
    DOI:  https://doi.org/10.1158/1940-6207.CAPR-18-4-HFL
  63. Arch Microbiol. 2025 May 13. 207(6): 145
    Endophytes of Zingiberaceae: distribution and bioactivity of their bioactive metabolites.
    Nor Hazwani Mohd Hasali, Muhammad Shahbaz, Jaya Seelan Sathiya Seelan, Nazirul Azam Ibrahim, Christophe Wiart, Nivaarani Arumugam, Mohammed Abdus Salam, Muneeb M Musthafa, Suganthi Appalasamy.
      The endophytes associated with the Zingiberaceae family have demonstrated remarkable potential in various biological activities through their bioactive compounds that are useful for both medical and agricultural purposes. Additionally, isolated secondary metabolites from symbiotic microbes associated with this family of plants have shown promising results in various biological activities such as antifungal, anticancer, antidiabetic, anti-inflammatory, and antibacterial. This review focuses on the bioactive metabolites of Zingiberaceae endophytes with their potential biological activities against different pathogens as well as the production of phytohormones that promote plant growth. Furthermore, bibliometric analysis revealed the current key trends and collaborative works in this field. Additionally, the bibliometric analysis also explored a total of 75 relevant publications from the Scopus database that India is the most contributing country in this field with 38.7% of the total reported research work. The bibliometric approach helps uncover new research gaps by identifying emerging trends, underexplored topics, and collaborative networks, providing insights into areas that require further investigation and development. Notably, Streptomyces spp. have been commonly reported as potent endophytes, generating bioactive substances such as Vanillin and Resacetophenone with strong antibacterial activities. Significant knowledge gaps still exist, and with evolving therapeutic potential, this could offer a wide opportunity for new studies to emerge.
    Keywords:  Beneficial microbes; Bioactive compounds; Biological activities; Phytopathogens; Sustainable agriculture and bibliometric analysis; Therapeutic potential
    DOI:  https://doi.org/10.1007/s00203-025-04335-x
  64. Front Plant Sci. 2025 ;16 1580007
    Visual analysis of research progress and trend on hairy roots.
    Yu-Ping Zheng.
      Hairy root is a special form of root tissue, which is induced by Rhizobium rhizogenes and could mediate genetic transformation after the infection of explants. They have attracted attentions because of their advantages of fast growth rate, convenient culture, stable genetic properties and strong synthesis ability of secondary metabolites. With bibliometrics, this study employed CiteSpace and VOSvivewer softwares to analyze the publications on hairy roots researches from 2009 to 2024 based on WOS database. The subject distribution, countries, institutions and personnel, research hotspots and research trends of hairy roots were discussed and analyzed. The results revealed a consistent increase in publications on hairy root with America, China and India as the main countries. The institutions were mainly universities and the Chinese Academy of Sciences was a major contributor to this topic and had close cooperation with other institutions. The researches of hairy roots mainly focused on plant genetic transformation, secondary metabolism and gene molecular function analysis, and in environmental remediation. The application of hairy roots could be an important research hotspot in the future.
    Keywords:  CiteSpace; VOSvivewer; bibliometrics; hairy root; visual analysis
    DOI:  https://doi.org/10.3389/fpls.2025.1580007
  65. Am J Surg. 2025 May 08. pii: S0002-9610(25)00216-8. [Epub ahead of print] 116394
    Gender and racial diversity in leadership roles within academic surgery internationally: a retrospective cross-sectional study pre-COVID-19.
    Téa C Sue, Isabella F Churchill, Caroline Mallity, Rebecca Lau, Daniel A Peters, Jacinthe Lampron, Philippe Phan, Alexandra Stratton, Eugene K Wai, Eve C Tsai.
       OBJECTIVE: Journal editorial and society executive boards have widespread impacts, however, the associated leadership diversity remains underexplored. Our study evaluated such diversity across four surgical specialties before the influences of COVID-19.
    METHODS: This retrospective, cross-sectional study obtained perceived gender and race of identified leaders from publicly available websites. Leadership of the top three journals and journal-affiliated societies based on the 2021 Journal Citation Reports journal impact factor was evaluated for subspecialties within neurosurgery, orthopaedic, general, and plastic surgery.
    RESULTS: Leadership diversity within 58 journals and 55 societies were reviewed. Orthopedics had a significantly lower proportion of females (p ​< ​0.05) and intersectional minorities (p ​< ​0.05). Higher journal impact factor and a greater proportion of intersectional minorities were significantly related (p ​= ​0.0009).
    CONCLUSION: We assessed leadership diversity amongst both journal editorial and society executive boards and identified differences with respect to proportions of females, minorities and intersectional minorities across specialties.
    Keywords:  Diversity; General surgery; Intersectionality; Neurosurgery; Orthopedic surgery; Plastic surgery
    DOI:  https://doi.org/10.1016/j.amjsurg.2025.116394
  66. Cogn Process. 2025 May 10.
    Advances in complex thinking and neurotechnologies in education: a bibliometric analysis of research trends.
    Jorge Sanabria-Z, Manuel Cebral-Loureda, Javier M Antelis, SeungHee Lee.
      Neuroscience research to decode cognitive and emotional processes has been widely embraced in education. The development of methodologies, case studies, and new technologies have advanced our understanding of students' complex thinking. Despite these advancements, long-term analysis at the convergence of neurosciences, education, and complex thinking remains limited. To address this gap, we conducted a bibliometric review using the prism method, spanning from 1960 to 2023 to map research trends, thematic evolutions, and future challenges. Our analysis of 3792 Scopus-indexed studies using advanced data visualization techniques yielded the following findings: (1) a predominant focus on critical thinking, with creativity driving innovative approaches that enhance problem-solving; (2) growing integration of neurotechnologies-such as EEG and neuroimaging-to assess and optimize cognitive engagement in educational settings; (3) an increasing emphasis on metacognition, highlighting its role as a reflective thinking strategy that fosters cogntive control and higher-order thinking; and (4) emerging research on executive functions, particularly their role in fostering decision-making and cognitive flexibility in learning environments. These findings contribute to the understanding of cognitive processes and inform practical applications in education, including the design of personalized learning strategies, real-time cognitive assessment tools, and neurotechnology-supported pedagogical models. The study advocates an interdisciplinary approach, integrating neuroscientific insights into complex thinking to enhance cognitive processing within STEAM education.
    Keywords:  Complex thinking; Educational innovation; Higher education; Neuroscience; Neurotechnologies
    DOI:  https://doi.org/10.1007/s10339-025-01273-w
  67. Int J Surg. 2025 May 12.
    Bibliometric analysis of brain-computer interface research in spinal cord injury: current landscape and future directions.
    Ming-Yue Liu, Ming-Zhu Fang, Bo-Han Zhang, Chun-Xiao Dang, Yi-Shen Zhang, Liang Wu, Bin Liu, Zhe Li.
      
    DOI:  https://doi.org/10.1097/JS9.0000000000002475
  68. Hum Vaccin Immunother. 2025 Dec;21(1): 2501358
    Mapping the landscape of AI and ML in vaccine innovation: A bibliometric study.
    Jirui Niu, Ruotian Deng, Zipu Dong, Xue Yang, Zhaohui Xing, Yin Yu, Jian Kang.
      With the rapid advancement of artificial intelligence (AI) and machine learning (ML) technologies, their applications in the medical field have expanded significantly. Particularly in vaccine innovation, AI and ML have shown considerable potential. This article employs bibliometric analysis to examine the progress of AI and ML in vaccine innovation over recent years. By conducting literature retrieval, data extraction, and intelligent analysis through Web of Science, it provides more accurate and comprehensive insights into vaccine development and dosimetry. The rapid growth in research publications since 2012, particularly the geometric growth observed since 2017, underscores the increasing recognition of the potential of AI and ML to revolutionize vaccine development. However, despite the substantial benefits of AI and ML in vaccine innovation, challenges remain regarding data quality, algorithm reliability, and ethical considerations. As technology continues to advance and research deepens, AI and machine learning are anticipated to play an even more pivotal role in vaccine innovation. Notably, AI has the potential to accelerate vaccine development timelines, particularly in the context of emerging infectious diseases. By leveraging data-driven insights and predictive modeling, AI can streamline processes such as antigen discovery, clinical trial design, and risk assessment, thereby enabling faster responses to public health emergencies. This capability is especially critical for addressing sudden outbreaks of infectious diseases, where rapid deployment of effective vaccines can significantly mitigate global health risks.
    Keywords:  Artificial intelligence; bibliometrics; machine learning; vaccines
    DOI:  https://doi.org/10.1080/21645515.2025.2501358
  69. Vox Sang. 2025 May 15.
    Forecasting emerging trends in transfusion medicine through complex network analysis of scholars' research.
    Feng Lin, Xu He, Huifang Zhang, Yi Huang.
       BACKGROUND AND OBJECTIVES: This study aimed to analyse and predict emerging trends in transfusion medicine using complex network analysis of high-impact global scholar rankings.
    MATERIALS AND METHODS: Network analysis was employed to uncover research trends, identify central research directions and map knowledge networks. The analytical hierarchy process was used to evaluate potential future research trajectories. The Kolmogorov-Smirnov test assessed network centrality differences, with cross-validation performed using the Association for the Advancement of Blood & Biotherapies (AABB) and the International Society of Blood Transfusion (ISBT) conference themes.
    RESULTS: Clinical transfusion is the central theme, with transfusion management, evaluation and specific transfusions like platelet and plasma gaining prominence. Blood safety evolved into a standalone domain, while immunohaematology and cell therapy represent emerging trends. Innovations in blood storage, transfusion technology and omics insights are shaping future directions. Notably, despite global healthcare impacts, COVID-19 has not significantly redirected transfusion medicine research.
    CONCLUSION: The transfusion medicine landscape demonstrates stability in its core framework while increasingly focusing on emerging areas such as personalized therapies, platelet transfusion and cell-based treatments.
    Keywords:  analytical hierarchy process; complex networks; discipline trends forecasting; topological properties of network
    DOI:  https://doi.org/10.1111/vox.70046
  70. Turk J Haematol. 2025 May 12.
    The Contribution of Turkish Hematology to Global Literature - A Comparative Analysis.
    Ömür Gökmen Sevindik, Yaşa Gül Mutlu, Fatih Demirkan.
      
    Keywords:  Bibliometrics; Hematology; Publications; Turkey
    DOI:  https://doi.org/10.4274/tjh.galenos.2025.2025.0029
  71. Eur J Orthod. 2025 Apr 08. pii: cjaf028. [Epub ahead of print]47(3):
    Research transparency in articles published in orthodontic journals: is it clear?
    Matthew Chi Hong Yii, Martyn T Cobourne, Nikolaos Pandis, Jadbinder Seehra.
       BACKGROUND: Issues regarding research transparency have been highlighted in the literature. The aim of this investigation was to assess the trend of adhering to the reporting of key transparency practices (data sharing, code sharing, COI disclosure, funding disclosure, and protocol registration) by articles published in three leading orthodontic journals.
    MATERIAL AND METHODS: A Scopus database search was undertaken to identify articles published in 2013, 2018 and 2023 in three orthodontic journals. Independent data extraction was performed. Frequency distributions and cross tabulations (COI not disclosed vs COI disclosed) were calculated. Univariable logistic regression was undertaken to detect associations between COI disclosure and publication characteristics, journal type and reporting of transparency practices.
    RESULTS: 1498 articles were analysed. No data sharing statement (60.7%) was commonly cited. The intention to share data was stated in approx. 15% articles. No article stated a code sharing statement. Almost 70% articles had not registered a protocol. A third of articles disclosed the funder or sponsor (32.7.%), while approximately an equal number of articles disclosed (49.1%) or did not disclose (50.9%) any conflict of interest. Articles published in the EJO had higher odds of reporting protocol registration (OR 7.42; 95% CI: 4.55, 12.10; P < .01) and funding disclosure (OR 3.44; 95% CI: 2.52, 4.69; P < .01) compared to AO and AJODO. A COI disclosure statement was more likely to be in articles published in AJODO. The odds of reporting a data sharing statement were higher in articles published in EJO (OR 8.72; 95% CI: 5.72, 13.29; P < .001). Apart from code sharing, improvements over the 5-year intervals in reporting of transparency indicators were evident.
    LIMITATIONS: Only three journals were assessed which may impact the generalisability of the results.
    CONCLUSIONS: Despite improvements over the 5-year intervals, the reporting of research transparency indicators requires improvement in articles published in orthodontic journals. To encourage transparent research conduct and open science practices, journals and their editors should promote reporting of research transparency indicators.
    Keywords:  COI disclosure; code sharing; data sharing; funding disclosure; orthodontic; protocol registration
    DOI:  https://doi.org/10.1093/ejo/cjaf028
  72. Eur Respir Rev. 2025 Apr;pii: 240246. [Epub ahead of print]34(176):
    Audio-based digital biomarkers in diagnosing and managing respiratory diseases: a systematic review and bibliometric analysis.
    Vivianne Landry, Jessica Matschek, Roger Pang, Meghana Munipalle, Kenneth Tan, Jill Boruff, Nicole Y K Li-Jessen.
      Advances in wearable sensors and artificial intelligence have greatly enhanced the potential of digitised audio biomarkers for disease diagnostics and monitoring. In respiratory care, evidence supporting their clinical use remains fragmented and inconclusive. This study aimed to assess the current research landscape of digital audio biomarkers in respiratory medicine through a bibliometric analysis and systematic review (PROSPERO CRD 42022336730). MEDLINE, Embase, Cochrane Library and CINAHL were searched for references indexed up to 9 April 2024. Eligible studies evaluated the accuracy of sound analysis for diagnosing and managing obstructive (asthma and COPD) or infectious respiratory diseases, excluding COVID-19. A narrative synthesis was conducted, and the QUADAS-2 tool was used to assess study quality and risk of bias. Of 14 180 studies, 81 were included. Bibliometric analysis identified fundamental (e.g. "diagnostic accuracy"+"machine learning") and emerging (e.g. "developing countries") themes. Despite methodological heterogeneity, audio biomarkers generally achieved moderate (60-79%) to high (80-100%) accuracies. 80% of studies (eight out of ten) reported high sensitivities and specificities for asthma diagnosis, 78% (seven out of nine) reported high sensitivities and 56% (five out of nine) reported high specificities for COPD, and 64% (seven out of eleven) reported high sensitivity or specificity values for pneumonia diagnosis. Breathing and coughing were the most common biomarkers, with artificial neural networks being the most common analysis technique. Future research on audio biomarkers should focus on testing their validity in clinically diverse populations and resolving algorithmic bias. If successful, digital audio biomarkers hold promise for complementing existing clinical tools in enabling more accessible applications in telemedicine, communicable disease monitoring, and chronic condition management.
    DOI:  https://doi.org/10.1183/16000617.0246-2024
  73. Med Teach. 2025 May 14. 1-10
    Increasing medical student participation in scholarly publications at a primary care-focused medical school.
    Em Long-Mills, Dmitry Tumin, Kori L Brewer, David L Eldridge, Jason D Higginson.
       INTRODUCTION: Research and scholarly activity during medical education can support medical students' ability to apply skills learned in the curriculum, develop professional networks, explore new interests, and strengthen their application for residency programs. Existing programs developed to facilitate medical student scholarly activity have typically resulted in poster or oral presentations of student work, but have encountered barriers to guiding student projects towards peer-reviewed publication. We sought to evaluate how a novel approach of offering both mentorship and logistical support for student scholarly activity within a school-level office contributed to medical students' output of peer-reviewed publications.
    METHODS: The Office of Clinical and Educational Scholarship (OCES) was established in 2021. Students graduating between 2015 and 2024 were included in the evaluation, and student publications during medical school were tracked using PubMed. Mixed-effects regression models quantified the association between OCES establishment and student publication outcomes in each calendar year.
    RESULTS: The proportion of students with a publication increased from 14% to 51% between the Classes of 2015-2024. Among the Class of 2024, the OCES team coauthored or consulted on 34 of 81 unique publications. On multivariable analysis, OCES establishment doubled students' odds of having any publication in a given calendar year (odds ratio: 2.3; 95% confidence interval [CI]: 1.3,4.0; p = 0.003) and the number of publications per year (incidence rate ratio: 2.2; 95% CI: 1.4,3.4; p = 0.001).
    DISCUSSION: By offering both mentorship and logistical support for scholarly projects in a centralized, flexible model, our office supported student engagement in scholarly work at students' own pace, and facilitated an increase in the proportion of students graduating with a publication to over half of the graduating class. This strategy can help other institutions meet students' demand for research opportunities progressing to publication, while helping students balance scholarly efforts with their medical school curriculum and other extracurricular activities.
    Keywords:  Evaluation; medical students; publications
    DOI:  https://doi.org/10.1080/0142159X.2025.2504112
  74. Clinics (Sao Paulo). 2025 May 12. pii: S1807-5932(25)00094-8. [Epub ahead of print]80 100670
    Sex and gender differences in cancer research and its application to clinical oncology and therapeutics.
    Rut Lucas-Domínguez, Cristina Rius, Yiming Liu, Andrea Sixto-Costoya, Juan Carlos Valderrama-Zurián.
       OBJECTIVES: Oncology has exhibited gender inequalities in leadership and authorship, alongside significant differences in cancer incidence, mortality, and survival rates between sexes. These disparities highlight the urgent need for sex- and gender-specific scientific reporting to improve research accuracy and clinical applications and encourage the same opportunities in research careers.
    METHODS: The integration of gender perspective in cancer was assessed by analyzing scientific publications comparing 2011 and 2021. The correlation between the gender of the authors and the different types of cancer studied was examined, as well as the inclusion of the sex and gender variables in the content of the research. The study was STROBE compliant.
    RESULTS: 3,194 papers were published in 2011 and 6,781 in 2021, signed by at least one Spanish institution. The ratio of female authors per article was 0.39 in 2011 compared to 0.43 in 2021, reaching parity. Gender bias in the content of scientific articles, as measured by a 10-item checklist, showed an unfavorable score for perspective integration in both years (1.7/10 and 1.8/10, respectively). In terms of the Gender Balance Index in the analyzed samples of the papers (cells, animals or volunteers/patients), there was an increase from 29 % in 2011 to 43 % in 2021. Breast cancer research was dominated by female authors, whereas lung cancer research was predominantly by parity or male authorship, and no differences in author groups in colorectal cancer research were observed.
    CONCLUSIONS: Greater efforts and commitments are needed from government institutions, funding agencies, and academic structures to promote sex/gender integration in cancer research.
    Keywords:  Cancer research; Gender bias; Gender gap; Sex and gender differences; Women's health
    DOI:  https://doi.org/10.1016/j.clinsp.2025.100670
  75. PLoS One. 2025 ;20(5): e0323297
    Business and entrepreneurship is declining as scholarly field: Empirical evidence.
    Wim Naudé.
      This paper presents evidence from 68,792 papers published between 1961 and 2020 that progress in the scholarly field of business and entrepreneurship is declining. It is found that the annual number of papers published in the field has increased exponentially since the Second World War, growing on average by 17% annually since 1961; the average disruption score of papers have declined by a factor of 36 between the 1960s and the 2010s; and that the average team size per paper has increased from 1,6 between 1960-1980-2,4 between 2000 and 2020. Estimates from an ideas production function suggest that the field is getting fished out and that researchers may be stepping on one another's toes. A Wald-test indicates that a structural break in the disruptiveness of business and entrepreneurship and papers occurred around 1999. These results could reflect pathologies in how research in the field is organized and/or that the field has matured.
    DOI:  https://doi.org/10.1371/journal.pone.0323297
  76. Plast Reconstr Surg. 2025 May 12.
    Forward Strides in Academic Plastic and Reconstructive Surgery Gender Representation: 2025 Update.
    Holly Cordray, Adina Singer, Helen Molteni, Saïd C Azoury.
       BACKGROUND: Although academic plastic and reconstructive surgery has trended toward dismantling gender disparities over the last decade, gaps remain within program leadership. This study mapped gender distributions of plastic surgery chiefs and program directors (PDs) in context of faculty and trainees to characterize how current leadership reflects and shapes the broader gender landscape.
    METHODS: In a national cross-sectional study, data on academic plastic surgery leaders, faculty, and trainees were extracted from program websites and/or social/professional media, determining gender using documented pronouns. Career metrics were collected for all leaders. Differences by gender were evaluated using Chi-square/Fisher's exact tests, independent-samples t-tests, and analyses of covariance. Associations among female representation in program leadership, faculty, and trainees were examined.
    RESULTS: As of 2025, women comprise 26.4% of faculty and 50.9% of residents; 0.1% are nonbinary. In comparison, 13.5% of department/division chiefs, 22.5% of primary PDs, and 43.1% of associate PDs are female. Associate PDs are significantly more likely than chiefs or primary PDs to be female (P < .001), indicating expansion of women entering leadership positions. Analyses of qualifications and professional attainment supported gender parity in selection and advancement of program leaders. PDs may shape trainee gender distributions: significant associations suggested greater inclusion of female residents at programs with female primary and/or associate PDs (P ≤ .03). Female vs male leaders were associated with significantly greater female faculty representation within their programs (approximately 150% relative magnitudes, P ≤ .005).
    CONCLUSIONS: Gender inclusion has progressed throughout academic plastic surgery; parity among trainees anticipates further shifts.
    Keywords:  academic surgery; equity; gender; leadership; plastic and reconstructive surgery
    DOI:  https://doi.org/10.1097/PRS.0000000000012196
  77. Global Spine J. 2025 May 16. 21925682251340033
    Characterizing the Representation of Different Global Regions and National Income-Levels Amongst Invited Speakers and Committee Members at Major International Spine Surgery Conferences.
    Jonathan Dalton, Joydeep Baidya, Rachel Huang, Jarod Olson, Chloe Herczeg, Robert J Oris, Rajkishen Narayanan, Evgeniy V Uvarov, Keyur Patel, Jose A Canseco, Alan S Hilibrand, Alexander R Vaccaro, Christopher K Kepler, Gregory D Schroeder.
      Study DesignObservational study.ObjectiveTo evaluate representation of countries and gross national income (GNI) at major international spine conferences.MethodsThe 50 most attended spine conferences were identified via ChatGPT. Conferences were excluded if they (1) reference/are held in a single country, (2) emphasize one technique, (3) emphasize neurosurgery or orthopaedic spine, (4) have <2 years of conference programs available. Programs were reviewed (2022-2024) to identify invited speakers/award recipients, executive board members, and committee members and their country of practice. Countries were assigned GNI/capita from World Bank data.ResultsEurospine, GSC, IMAST, ISASS, NASS, and SRS met inclusion criteria (1462 unique invited speakers/awardees). Other than Eurospine, board members were predominantly from Northern America. Speakers were most commonly from Northern America (56.2%), with no representation from Southern Africa and Central Asia. Speakers were overwhelmingly from high-income countries (89.7%) with none from low-income countries. Speakers at GSC were the most globally representative, with 68.8% from countries diverse from GSC's executive board. GSC and NASS had the greatest representation from lower-middle (9.7%) and upper-middle income countries (30.4%), respectively. USA and Germany had 867 (59.4%) invitees, while all of Africa had four. Committee members followed similar trends compared to invited speakers for region, country, and GNI/capita representation.ConclusionsAmongst major international conferences, a preponderance of invited speakers and committee members were from a small number of regions, particularly Northern America and Western Europe. Most speakers and committee members practice in high-income countries, with no representation from low-income countries.
    Keywords:  global collaboration; gross national income; international spine conference representation; international spine conferences; spine surgery equity
    DOI:  https://doi.org/10.1177/21925682251340033
  78. Anaesthesia. 2025 May 12.
    An analysis of publication trends in Science Letters published in Anaesthesia.
    Navniel Kaur, Michael G Irwin, Ben Morton.
      
    DOI:  https://doi.org/10.1111/anae.16638
  79. Med Teach. 2025 May 15. 1-2
    Knowledge circulation and the politics of citation: Referencing is not a neutral act.
    Jennifer Cleland.
      
    DOI:  https://doi.org/10.1080/0142159X.2025.2504313
  80. J Emerg Med. 2024 Dec 04. pii: S0736-4679(24)00362-7. [Epub ahead of print]
    Impact of the First Swiss Conference on Prehospital Emergency Care and Trauma Research (SPECTRe) on Paramedics' Intention to Engage in Research: Cross-sectional Study.
    Samuel Zünd, Loric Stuby, Laurent Suppan, Johan N Siebert, Jean-Marie Tinembart.
       BACKGROUND: In Switzerland, paramedics lack academic training, meaning they do not receive specialized education in the field of research. Like many other European countries, paramedics are seldom included in prehospital research. However, considering the significant gaps in knowledge within prehospital emergency medicine, educating and involving paramedics could markedly enhance prehospital emergency medicine research and decrease knowledge gap in this area.
    STUDY OBJECTIVE: This cross-sectional study aimed to evaluate the impact of the inaugural Swiss Conference on Prehospital Emergency Care and Trauma Research on paramedics' inclination to participate in prehospital research.
    METHODS: A questionnaire was administered using Likert-type scales. All participants (100) were asked to answer a web-based questionnaire after attending the conference.
    RESULTS: Out of 80 responses (80%), 72 were filled by paramedics and therefore included in the analysis. Participants were significantly more willing to engage in prehospital research after attending the conference (40/56, 71.4%) than before (23/56, 41.1%); p < 0.001. Among participants already actively involved, 46.7% (7/15) responded that the event had a positive impact on their level of involvement. The results revealed a noteworthy increase in willingness to engage in research.
    CONCLUSIONS: A one-day conference solely focused on pre-hospital scientific research serves as a motivating factor for paramedics to partake in research in this domain. Whether this will lead to a higher scientific output is unknown.
    Keywords:  emergency medical services; paramedic; public health systems research; research
    DOI:  https://doi.org/10.1016/j.jemermed.2024.11.017
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