bims-evares Biomed News
on Evaluation of research
Issue of 2025–05–11
58 papers selected by
Thomas Krichel, Open Library Society



  1. Medicine (Baltimore). 2025 May 02. 104(18): e42282
      This bibliometric analysis explores the current status and trends of global research on posterior capsular opacification (PCO). A search of the Web of Science Core Collection (WoSCC) database was conducted to identify publications on PCO from 2011 to 2023. Bibliometric analysis was used to explore publication trends in PCO-related research. VOSviewer v.1.6.20 was used to visualize country, institution and author productivity and collaborations, as well as research hotspots. CiteSpace 6.3.R1 was applied to extract the burst references and keywords. A total of 988 PCO-related documents were included. The largest number of publications (283) and citations (3538) were from China. Of these, the largest number of publications (41) and citations (655) were from Wenzhou Medical University. Quankui Lin published 31 articles and was the most productive author. The journal with the highest productivity (121 publications) was the Journal of Cataract and Refractive Surgery. The top 3 cited references mainly presented intraocular lens (IOL) optic material/design and surgical technique on the development of PCO; the mechanism of PCO formation. The keywords mainly formed 5 clusters: the prevalence and risk factors for PCO; the mechanism of PCO formation; the material and design of IOLs and their application in the prevention of PCO; the application of IOLs surface modification and drug delivery in the prevention of PCO; and complications associated with Nd:YAG laser capsulotomy. Based on the raw data from WoSCC, analyzing research hotspots can offer valuable insights into PCO studies.
    Keywords:  CiteSpace; VOSviewer; bibliometric analysis; posterior capsular opacification
    DOI:  https://doi.org/10.1097/MD.0000000000042282
  2. Medicine (Baltimore). 2025 May 02. 104(18): e41939
       BACKGROUND: Osteoporosis (OP) is the second most detrimental chronic disease, and thus novel diagnostic and therapeutic approaches are needed. In recent years, there has been an increased emphasis on the utilization of gut microbiota (GM) in the context of OP. However, a comprehensive bibliometric analysis on this subject is currently lacking. Furthermore, a deeper exploration of the role of GM in bone health is imperative, and there is a pressing need to foster international and inter-agency exchange and experience in this field. Accordingly, this study aimed to provide an overview of the research trends in this field and propose suggestions for related scientific and technological research and development.
    METHODS: The Web of Science database was searched for articles related to both GM and OP. Statistical analyses and data visualization were performed using the EXCEL and CiteSpace software.
    RESULTS: China exhibited the highest number of publications, followed by the United States. NUTRIENTS and Sichuan University were identified as the journal and institution, respectively, with the highest number of articles. Notably, the keywords "gut microbiota" and "bone loss" have been increasingly used in publications.
    CONCLUSION: In conclusion, this study fills the existing gap in the literature and contributes valuable insights to the understanding of the relationship between GM and OP.
    Keywords:  CiteSpace; bibliometric analysis; bone health; gut microbiota; osteoporosis; visualization analysis
    DOI:  https://doi.org/10.1097/MD.0000000000041939
  3. Curr HIV Res. 2025 May 02.
       INTRODUCTION: The enduring presence of HIV reservoirs represents an important obsta-cle to clinical management. Extensive research has been conducted in this field, but there are no bibliometric analyses focusing on HIV reservoir research.
    AIM: This study aimed to present the current status and global trends in HIV reservoir research through bibliometric analysis.
    METHODS: Studies on HIV reservoirs published from 1 January 1994 to 31 December 2023 were included in the Web of Science Core Collection database, and annual publication numbers, insti-tutions, countries, and authors were analysed using CiteSpace bibliometric software. Further-more, popular research topics and trends were analysed using co-cited references and keywords. From 1994 to 2023, 5778 publications on HIV reservoirs were included, with the United States producing the most publications, citations, and research funding. The most productive individual author was Nicolas Chomont. Cell was the journal publishing the most publications, while Nat Med had the best total link strength. The University of California System was the institution that made the greatest contribution. Keyword clustering analysis of the extracted publications indi-cated that the research areas over the past three decades have primarily focused on "central nerv-ous system," "histone deacetylase," "multiple Epstein‒Barr virus infection," and "dendritic cell."
    RESULTS: Moreover, keyword emergence analysis indicates that "provirus" and "identification" are likely to become central themes in future research. Future investigations should prioritize elucidating the specific mechanisms underlying proviral persistence and the identification of novel biomarkers in HIV reservoirs. Additionally, exploring the role of proviral dynamics in ther-apeutic development and reservoir targeting could offer new insights into potential treatment strategies.
    CONCLUSION: This study makes a significant contribution to the understanding of HIV reservoirs, shedding light on key characteristics and emerging trends while also pointing to future research directions.
    Keywords:  CiteSpace; HIV reservoirs; emerging trends.; visualization analysis
    DOI:  https://doi.org/10.2174/011570162X360028250418095855
  4. Discov Oncol. 2025 May 06. 16(1): 671
       OBJECTIVE: Clonal hematopoiesis (CH) refers to the clonal expansion of hematopoietic stem cells caused by somatic mutations. CH is commonly observed in elderly individuals and is closely associated with myeloid malignancies as well as various non-malignant diseases. This study aims to explore the research trends and hotspots of CH using bibliometric analysis.
    METHODS: Relevant studies were retrieved from the Web of Science Core Collection database based on predefined inclusion criteria. Bibliometric analysis and visualization were conducted using VOSviewer, CiteSpace, and R software.
    RESULTS: A total of 851 studies were included. From 2014 to 2024, the annual number of publications showed a consistent upward trend. The United States was identified as the leading country in this field, contributing 53.7% of the total publications. Harvard Medical School and Benjamin L Ebert were recognized as the most influential institution and author, respectively. Blood was the most prolific journal, with the highest citation and H-index. Research on CH-related gene mutations and their association with the risk of acute myeloid leukemia is currently the most extensively studied area, while cardiovascular diseases and inflammation have emerged as recent research hotspots.
    CONCLUSION: This study is the first to systematically analyze research related to CH using bibliometric methods. Our analysis reveals the overall landscape of CH research and identifies the most influential contributors in the field, including countries, institutions, authors, and journals. Moreover, we identify emerging research hotspots and key areas, highlighting potential avenues for exploration and innovation within the field of CH.
    Keywords:  Bibliometric; Clonal hematopoiesis; Research hotspots; Research trend; Visualized
    DOI:  https://doi.org/10.1007/s12672-025-02517-z
  5. Front Surg. 2025 ;12 1559951
       Background: Recent studies have demonstrated significant advancements in the treatment of hyperhidrosis. However, a bibliometric analysis of relevant studies in this field is notably lacking. This study aims to provide a detailed analysis of research trends and key areas of interest in hyperhidrosis over the last 16 years using bibliometric methods.
    Methods: We searched the Web of Science Core Collection (WoSCC) database for hyperhidrosis-related publications from 2008 to 2023 and conducted bibliometric analysis using VOS viewer and the R package "bibliometrix."
    Results: The main research institutions involved in this study are the University of São Paulo, Hospital Israelita Albert Einstein, Yonsei University and Fujian Medical University, with a total of 728 articles included from 52 countries. Authors from these institutions have published in top journals, with Dermatologic Surgery being the most popular journal and the Journal of the American Academy of Dermatology being the most cited. A total of 2,830 authors have contributed to this field, with prominent researchers including Nelson Wolosker, Paulo Kauffman, Pedro Puech-Leão, Jose Ribas Milanez de Campos, and Dee Anna Glaser. Nelson Wolosker stands out as the most co-cited author. The primary focus of research in this area is on the treatment of hyperhidrosis and the prevention of post-operative complications. Emerging re-search hotspots include keywords such as "botulinum toxin," "oxybutynin," "sympathectomy," "iontophoresis," and "compensatory sweating".
    Conclusion: The most prevalent academic emphasis within this field remains the treatment of hyperhidrosis and the management of compensatory hyperhidrosis. Despite this academic preponderance, there is a compelling necessity to foster enhanced collaboration and exchange between disparate countries and institutions.
    Keywords:  VOS viewer; bibliometric; compensatory sweating; hotspots; hyperhidrosis
    DOI:  https://doi.org/10.3389/fsurg.2025.1559951
  6. Ann Med Surg (Lond). 2025 May;87(5): 2718-2735
       Background: Osteonecrosis of the femoral head (ONFH), caused by disrupted blood supply leading to bone cell death and joint collapse, remains a critical orthopedic challenge. While core decompression has advanced significantly in ONFH treatment, no bibliometric analysis has mapped its research landscape.
    Method: We analyzed 854 articles from the Web of Science Core Collection (1986-2023) using VOSviewer, CiteSpace, and bibliometrix.
    Results: Publications surged from 5.4/year (1986-2001) to 52.3/year (2015-2023), reflecting intensified interest. China (253 articles, 29.6%) and the United States (232, 27.2%) dominated contributions, with Stanford University and Johns Hopkins University as top institutions. International collaborations linked China to the United States, Germany, and England. Clinical Orthopaedics and Related Research was the most cited journal (4708 citations). Keyword analysis revealed emerging hotspots: mesenchymal stem cells (19 occurrences), cell therapy, and angiogenesis. Citation bursts highlighted Mont MA's seminal work (burst strength: 19.67) on joint-preserving strategies and stem cell-enhanced core decompression.
    Conclusion: This first bibliometric study delineates trends, collaborations, and frontiers in core decompression for ONFH, emphasizing the translational potential of stem cell therapies.
    Keywords:  VOSviewers; bibliometrics; citeSpace; core decompression; osteonecrosis of the femoral head
    DOI:  https://doi.org/10.1097/MS9.0000000000003110
  7. Front Reprod Health. 2025 ;7 1519249
       Background: Polycystic Ovary Syndrome (PCOS) is a common endocrine and metabolic disorder affecting women of reproductive age. Over the past 30 years, significant efforts have been devoted to exploring its various pathogenic mechanisms, physiological and pathological characteristics, and biomarkers. Among these, Anti-Müllerian Hormone (AMH), as a biomarker for PCOS, is a significant biomarker for diagnosing, treating, and monitoring. However, the individual key information extracted from numerous studies is difficult to apply in clinical practice. Therefore, this article employs bibliometric analysis to summarize the current state of knowledge and offer future perspectives.
    Methods: The Science Citation Index Expanded (SCI-E) within the Web of Science Core Collection database has been identified as the material source for obtaining articles related to AMH and PCOS. Software such as Origin, Microsoft Excel, Pajek, VOSviewer, and CiteSpace were used for bibliometric analysis and statistical assessment, evaluating countries, institutions, journals, references, and authors, as well as for constructing visual knowledge network maps.
    Results: From 1994 to 2024, a total of 1,082 articles were included in the bibliometric analysis of research on AMH and PCOS. The number of publications in this field has consistently increased, with contributions from 70 countries, 1,363 institutions, and 5,144 researchers worldwide. Among them, the United States and China are the two countries with the highest number of publications. Zhejiang University, Monash University, and Peking University rank among the top three institutions exhibiting explosive citation bursts. The author with the highest publication volume is Didier Dewailly. The predictive keywords associated with these articles include "consensus," "morphology," "criteria," "prevalence," and "Müllerian hormone."
    Conclusions: Through bibliometric analysis, this study has identified the primary research hotspots in the field of AMH and PCOS as follows: (1) Refining the diagnostic criteria for PCOS by using AMH as a biomarker; (2) Exploring the molecular role of AMH in the pathophysiological processes of various PCOS phenotypes and its potential as a therapeutic target; (3) Analyzing the impact of baseline AMH levels on female reproductive health and other biomarkers; (4) Investigating the signalling mechanisms of AMH in PCOS and its role in disease progression.
    Keywords:  AMH; CiteSpace; PCOS; VOSviewer; bibliometric analysis
    DOI:  https://doi.org/10.3389/frph.2025.1519249
  8. J Eval Clin Pract. 2025 Jun;31(4): e70111
    Evidence in Cardiovascular Anesthesia (EICA) Group
       BACKGROUND: Remote ischemic preconditioning (RIPC) is a key area in cardiovascular research, but inconsistent findings have made it hard to fully understand. Bibliometrics, using mathematics and statistics, can track trends and progress in research over time. This study uses bibliometrics to assess RIPC trends and hotspots in cardiac surgery, aiming to better understand future research.
    METHODS AND RESULTS: Studies on RIPC were retrieved from the Web of Science Core Collection, with 104 studies included contributing countries, collaborative countries, institutions, authors, journals, keywords, research topics, citation patterns, and the current state of research. in this field were visually analyzed by using R platform, VOS viewer, and Microsoft Excel. These publications mainly came from 29 countries and 65 institutions. All experiments were clinical studies, and the type of surgery involved was cardiac surgery. A significant percentage of publications occurred during the period from 2010 to 2020 (75; 72.11%). Germany made the most significant contribution to this field with 27 (25.96%) papers and had the highest total citation count (2314). J Thorac Cardiovasc Surg published the most studies (n = 6), followed by Basic Res Cardiol (n = 5). We identified 89 authors, among which Patrick Meybohm, Juergen Peters, and Matthias Thielmann had the most studies (n = 10).
    CONCLUSIONS: RIPC has significant research value and potential in cardiac surgery, mainly focusing on organ protection during adult heart surgeries, especially myocardial protection. Although Germany and China are leading, more international cooperation is needed. Large-scale, standardized randomized controlled trials on RIPC are essential to provide higher-level evidence-based medical research.
    Keywords:  bibliometric analysis; cardiac surgery; remote ischemic preconditioning; web of Science
    DOI:  https://doi.org/10.1111/jep.70111
  9. J Vis Exp. 2025 Apr 18.
      Cancer poses a significant challenge to human health due to its complex biological systems, necessitating in-depth analysis. Single-cell sequencing has become an essential tool for investigating these systems, enabling the detection of gene expression and epigenetic modifications at the single-cell level. To elucidate research trends, collaboration networks, and knowledge dissemination in this field, a bibliometric analysis was conducted using the Web of Science Core Collection database, covering publications from January 1, 2010, to December 31, 2023. The Bibliometrix package in R was used to extract and analyze key publication data, including document types, countries, institutions, authors, and keywords. Additionally, CiteSpace, VOSviewer, and the Online Analysis Platform of Literature Metrology were employed for data compilation and visualization. The analysis identified 34,074 authors from 3,129 institutions across 75 countries and regions, contributing to 5,680 publications on single-cell sequencing in cancer, published in 788 academic journals. China and the United States emerged as the leading nations in publication volume. Harvard University produced the highest number of publications (320), with Aviv Regev, affiliated with Harvard, recognized as a key contributor. Leading journals, such as Frontiers in Immunology and Nature Communications, highlight both established and emerging research areas, including the immune microenvironment and immunotherapy. Key trends and potential areas for future research include intra-tumor heterogeneity, clonal evolution, and drug delivery systems. This study provides a comprehensive overview of single-cell sequencing research in oncology, emphasizing its rapid progress, driven by technological advancements and international collaborations. Strengthening global partnerships, developing integrative analytical tools, and addressing data complexities will be crucial for advancing personalized cancer therapies and deepening insights into cancer biology.
    DOI:  https://doi.org/10.3791/67880
  10. Medicine (Baltimore). 2025 May 02. 104(18): e42257
      Type 2 diabetes mellitus (T2DM) is estimated to impact 693 million individuals globally by 2045. Diabetes remission has the potential to slow disease progression, alleviate psychological burdens, minimize complications, and improve quality of life. We aimed to perform a bibliometric analysis of research on T2DM remission. We searched the Web of Science (WoS) database to identify relevant publications on T2DM remission during 2002 to 2022. Research trends and hotspots in T2DM remission were analyzed using Bibliometrix R and CiteSpace. The analysis considered various factors such as publication year, authors, journal, institution, country/region, themes, thematic evolution, keywords, and keyword bursts. The WoS search yielded 2254 articles. The annual scientific output has consistently increased. Lee was the most prolific author (48 papers). Obesity surgery was the leading journal (296 publications), while diabetes care had the highest h_index (43). The University of Copenhagen was the most active institution (116 papers). The most productive countries were the US (476), China (347), the UK (180), Italy (121), and Japan (90). The top 3 keywords were "bariatric surgery," "weight loss," and "remission." From 2013 to 2015, the usage of the term "medical therapy" significantly surged, lasting for 3 years. The term "GLP-I receptor agonists" also had a lasting burst. In the past 5 years, "weight loss" and "low-calorie diets" have emerged as prominent areas of research. This study analyzed the research trends and key factors in the field of type 2 diabetes mitigation through bibliometrics, providing important data support and a basis for decision-making for future research and public health policies.
    Keywords:  bibliometrics; diabetes mellitus; emerging trends; remission; spontaneous; type 2
    DOI:  https://doi.org/10.1097/MD.0000000000042257
  11. Medicine (Baltimore). 2025 May 02. 104(18): e42367
       BACKGROUND: A large number of studies have shown that osteoporosis is closely related to bone immunology. The purpose of this study is to conduct bibliometrics and visual analysis of the fields related to osteoimmunology and osteoporosis from 2013 to 2022 and to summarize the research hotspots and trends in this field.
    METHODS: We searched the Web of Science core collection database for articles on osteoimmunology and osteoporosis published between 2013 and 2022. Vosviewer 1.6.18 and CiteSpace.6.2. R4 were used to analyze the retrieved data.
    RESULTS: A total of 3218 articles on osteoimmunology and osteoporosis were included in this study. A total of 76 countries, 347 institutions, and 502 authors were included in the articles examined in this study. The main research countries were China, the United States, and South Korea. Shanghai Jiaotong University, Harvard University, and the University of California system were the main research institutions. The author who published the most papers was Xu, Jiake.
    CONCLUSIONS: This study is the first to summarize the global research trends in the field of osteoimmunology and osteoporosis from 2013 to 2022. That helps researchers quickly understand the research hotspots and directions in this field.
    Keywords:  CiteSpace; Vosviewer; bibliometrics; osteoimmunology; osteoporosis
    DOI:  https://doi.org/10.1097/MD.0000000000042367
  12. Pak J Biol Sci. 2025 Mar;28(4): 189-203
      <b>Background and Objective:</b> Ticks are well-known parasites that cause significant adverse effects on goat husbandry. They negatively affect the health of the goat and impair the economic sustainability and productivity of the animal. The present study illustrated the findings on the global research trends of scholarly literature with respect to goat ticks. <b>Materials and Methods:</b> A search keyword was done as related to the subject matter of goat ticks. All articles from the year 2024 were removed from the initial sum of 2018 documents in order to allow for the reproducibility of the method. A sum of 2013 documents was retrieved from Scopus and Web of Science Databank for evaluation using bibliometric permutations in RStudio software. After data were obtained from WoS and Scopus, they were then cleaned up and filtered before they were validated for analysis. <b>Results:</b> Research articles on goat ticks had rising research outputs of an annual increase of 7.36%. China led in the rankings with the highest amount of research outputs (n = 183) and citations (n = 3751) globally. The result also revealed the co-authors per document (n = 6.35), single-authored documents (n = 133), average citations per document (n = 18.65) and percentage of international co-authorships (18.43 %), accordingly. South Africa, Ethiopia, Tunisia and Kenya were the only African countries that were ranked among the top-rated 20 nations on goat ticks. <b>Conclusion:</b> The annual increase in research investigations on goat ticks over the seven decades of bibliometric assessments indicates the economic significance of tick-borne disease in goat farming.
    Keywords:  Caprine; bibliometric analysis; schematic characterization; scientometric; ticks
    DOI:  https://doi.org/10.3923/pjbs.2025.189.203
  13. Technol Health Care. 2025 May;33(3): 1159-1168
      ObjectiveAnalyze the research trends and hotspots in emergency department overcrowding derived from the Web of Science Core Collection database.MethodsThe Web of Science Core Collection database was utilized as the search data source for the bibliometric analysis, and the associated articles published from January 1, 1990, to October 1, 2023.The search was executed using the following formula: TS = (crowded OR overcrowd OR crowding OR overcrowding) AND TS = (Emergency department). VOSviewer, Scimago Graphicaand and additional tools were utilized for bibliometric analysis, and visual knowledge graphs were created.ResultsA total of 1869 articles were included in this study. The country with the largest number of publications is the United States. The primary research institution is the University of Toronto. Jesse M. Pines and his group at George Washington University have the greatest influence in the field of emergency department overcrowding research. Carlos A. Camargo is the author with the highest h-index in this field. High-frequency keywords include "length-of-stay", "impact", "mortality", "triage", "association", "outcomes", "time", "management", "access block", and "quality". The clustering graph reveals that all keywords fall into seven categories.ConclusionWe recommend intensifying research on emergency department overcrowding in more developing countries. In the future, the application of emerging technologies in emergency medicine as well as the mental health of emergency patients and medical staff may become research hotspots in this field.
    Keywords:  Scimago Graphica; VOSviewer; bibliometric analysis; emergency department overcrowding
    DOI:  https://doi.org/10.1177/09287329241303039
  14. J Emerg Nurs. 2025 May 08. pii: S0099-1767(25)00133-3. [Epub ahead of print]
       INTRODUCTION: Workplace violence against health care workers is a widespread global issue, particularly in emergency departments. This study aimed to identify and visualize research on workplace violence in the emergency department and reveal global trends in this field.
    METHODS: Publications related to workplace violence in the emergency department were retrieved from the Web of Science Core Collection database. VOSviewer, CiteSpace, and Scimago Graphica were used for bibliometric analysis and visualization.
    RESULTS: A total of 348 articles were selected for this study. These articles were published across 50 countries from November 1, 1988 to December 31, 2024, with the United States, Australia, and China leading in publication output. These articles were featured in 142 journals, with the Journal of Emergency Nursing publishing the most (n = 33). Gillespie is both the most prolific author and among the most frequently cited in this field. Keyword clustering analysis identified 4 distinct research themes, including factors associated with the occurrence of violence, prevention strategies for workplace violence, its psychological and occupational impacts on emergency department staff, and different forms of violence. In addition, keyword burst analysis revealed emerging trend topics, notably "COVID-19," "experience," and "qualitative research."
    DISCUSSION: Despite a growing body of research on workplace violence in the emergency department in recent years, incidents of violence continue to arise. This bibliometric study is the first to comprehensively summarize the research developments and trends in this field, identifying research frontiers and hotspots. The findings offer new perspectives on workplace violence in the emergency department and may inform future research on violence prevention strategies.
    Keywords:  Bibliometric analysis; Emergency department; Emergency staff; Research status; Workplace violence
    DOI:  https://doi.org/10.1016/j.jen.2025.04.003
  15. J Nurs Manag. 2025 ;2025 4285361
      Aim: To conduct a bibliometric analysis of the nurses' job satisfaction from 2004 to 2023. Design: The bibliometric and visual analysis was performed in January 2024. Methods: Bibliometric approaches were applied to analyse 11,993 articles, utilising R and VOSviewer software. Results: Articles published by 24,155 authors from 1735 distinct sources between 2004 and 2023 were retrieved from the Web of Science and incorporated into the research's purview. The most productive nation and institution correspondingly were the United States and the University of Toronto. The leading scholars in this sphere were Spence Laschinger, Heather K, Labrague, Leodoro J, and Rodwell, John according to Price's Law, author co-citation and bibliographic-coupling network analysis. 14,152 keywords about nurses' job satisfaction study were discovered in this research. The most common keywords encompassed "job satisfaction," "nurses," "burnout," "turnover," and "intention" It was also observed that while trend topics like "work engagement" "COVID-19" and "grit" have gained popularity recently, the most commonly employed trend topics in earlier years included "empirical research report" "longitudinal study," and "organizational characteristics." Conclusion: Research on nurses' job satisfaction remains relatively limited and requires more attention, especially in developing countries. Developed countries, especially the United Kingdom and the United States, are the main contributors to nurse job satisfaction research. In the early days, nurse job satisfaction research mainly focused on the current status and influencing factors of nurse job satisfaction in different medical organizations, nurse groups or departments, while more researchers have recently paid more attention to research on specific issues emerging in this field, such as the impact of COVID-19 on nurse job satisfaction and turnover. In addition, scholars in the field of nurse job satisfaction focus on finding the real determinants of job satisfaction of adult practicing nurses, such as interpersonal value consistency, human resource management, and the impact of job satisfaction of adult nurses in different medical environments. Topics such as "perseverance," "COVID-19" and "work engagement" may be potential focuses for future research. Furthermore, transnational research should be given greater emphasis to investigate whether the major factors and effective interferences of nurses' job satisfaction differ between cultures and more multicenter as well as big sample studies should be conducted to efficiently improve nurses' job satisfaction. Impact: This study used bibliometric analysis to examine the most contributing nations, institutions, authors, trend topics, and research focus. Data on the present state of nurses' job satisfaction research, including its knowledge maps, study emphasis, and thematic trends are few. The findings of this research can lay a strong basis for future research and offer direction. No Patient or Public Contribution: There were no humankind subjects in the bibliometric analysis of published papers.
    Keywords:  Web of Science; bibliometric analysis; job satisfaction; nurses
    DOI:  https://doi.org/10.1155/jonm/4285361
  16. Front Neurol. 2025 ;16 1412152
       Objective: This study analyzes trends and hotspots in the research on exercise for insomnia using bibliometric methods and visually presents key information in the field.
    Methods: Using Web of Science Core Collection as a source of literature, Microsoft Excel 2019, CiteSpace, VOSviewer, and the Bibliometrix package based on R language software were used to create visualization graphs and analyze the publications by country and region, institution, journal, author, reference, and keyword.
    Results: This study included 1,419 papers. The overall number of publications showed an increasing trend, and the highest number of papers in this field were published by the United States and China by country, the University of California System in the United States by institution, and Markus Gerber from Switzerland by author. The trends and hotspots in this field identified through keyword analysis include "insomnia," exercise," "depression," "older adults," and "quality of life."
    Conclusion: The research field of exercise therapy for insomnia is receiving increasing attention, and this study provides a clear and intuitive reference for researchers.
    Keywords:  bibliometrics; exercise; insomnia; quality of life; sleep
    DOI:  https://doi.org/10.3389/fneur.2025.1412152
  17. Skin Res Technol. 2025 Feb-May;31(2-5):31(2-5): e70164
       BACKGROUND: Wound healing is a complex process with significant economic implications. Hyaluronic acid (HA), valued for its adaptability and biocompatibility, shows the potential to improve multiple facets of wound healing. Despite the expanding literature on the use of HA in wound care, a comprehensive analysis of its scholarly evolution is lacking. This study employs a bibliometric approach to objectively evaluate trends in scholarly publications regarding HA's role in promoting wound healing.
    METHODS: We searched in the Web of Science Core Collection (WoSCC) for articles published from January 1, 2000 to March 31, 2024. We extracted relevant information about using HA to promote wound healing following a thorough screening process. Subsequently, a comprehensive analysis was undertaken on a total of 1886 publications. The analysis utilized GraphPad Prism 9, CiteSpace6.1.6, VOSviewer1.6.19, the Online Analysis Platform of Literature Metrology (http://bibliometric.com/), GeneMANIA (https://genemania.org/), and Metascape (https://metascape.org/gp/index.html#/main/step1).
    RESULTS: We retrieved 2424 publications on hyaluronic acid (HA) and wound healing from the Web of Science Core Collection, covering the period from January 2000 to March 2024, and selected 1886 for analysis. The results show a significant increase in publications since 2016, reflecting a growing focus on this field. Currently, China's publication volume has surpassed the United States since 2017, indicating a significant rise in China's influence in this area. Using CiteSpace software for co-citation analysis, we identified eight main research clusters, including promoted wound healing, injured tissue, and advanced multi-targeted composite biomaterial. Key research areas involve the role and mechanisms of hyaluronic acid in tissue repair, particularly its applications in growth factor production and regenerative therapy. Analyzing keyword co-occurrence and burst data with VOSviewer, we identified research hotspots focused on biomaterials, such as nanoparticles and hydrogels, and their antibacterial properties. The keyword "CD44" showed a long burst period, while "antibacterial" had the highest burst intensity in 2022. We identified the top 21 genes extensively studied in hyaluronic acid and wound healing, including CD44, VEGF, and TGF-β. These genes are mainly involved in regulating cell migration, adhesion, proliferation, and cytokine activity. GO enrichment and KEGG pathway analyses indicate that these genes are associated with key signaling pathways, such as MAPK and EGFR, revealing the primary mechanisms hyaluronic acid promotes wound healing.
    CONCLUSION: This pioneering study provides the first comprehensive bibliometric analysis of HA in wound healing. Covering the period from January 1, 2000 to March 31, 2024, it reveals a significant expansion in annual scholarly production. Current research emphasizes the development of HA-based biomaterials for enhancing wound healing.
    Keywords:  bibliometric analysis; hyaluronic acid; research hotspots; visualization; wound healing
    DOI:  https://doi.org/10.1111/srt.70164
  18. Ann Med Surg (Lond). 2025 May;87(5): 2812-2828
       Background: Normothermic machine perfusion (NMP) has increased substantially in the recent decade, being a vital tool in further organ preservation and reducing ischemia-reperfusion injury. The purpose of this study was to objectively conduct a bibliometric analysis of the top 100 cited articles to understand the evolution of NMP in liver transplantation.
    Methods: Scopus was selected as our primary database. We explored the database to extract relevant articles, which were then ranked numerically by the number of citations. A list of the top 100 articles was created in descending order, and each article was further analyzed to identify trends and characteristics. A list of the top 10 review articles was also prepared.
    Results: The top 100 studies were cited a total of 6136 times from 2013 and 2023, with the most cited articles published in 2018. The total number of citations per article ranged from 7 to 787, with a median of 397 citations. The articles originated from 13 different countries, with the United Kingdom having the most articles (n = 26), followed by the Netherlands (n = 17) and the United States (n = 17). Liver Transplantation (n = 21), Transplantation (n = 10), American Journal of Transplantation (n = 10), and Annals of Surgery (n = 6) contributed to nearly half of the articles.
    Conclusion: Research on NMP is rapidly growing and encompasses a variety of countries and institutions. Our analysis provides insight into the evolution of normothermic machine perfusion in liver transplantation, with the hope that this article may serve as a reference to aid healthcare professionals in efficiently assessing consensus, trends, and needs within the field.
    Keywords:  liver grafting; liver transplantation; normothermic machine perfusion; normothermic perfusion and hepatic grafting; normothermic preservation
    DOI:  https://doi.org/10.1097/MS9.0000000000003222
  19. Discov Oncol. 2025 May 09. 16(1): 711
       OBJECTIVES: Macrophages play a critical role in various diseases, including cancer, where their involvement is characterized by a dual nature. There is a growing focus on tumor-associated macrophages (TAMs) in cancer research due to their complex interactions with tumor biology. With the expanding body of research in this area, a retrospective analysis of published articles is warranted to gain insights into evolving trends. This bibliometric study aims to assist researchers in identifying key areas of interest and emerging directions within the field of TAM research.
    METHODS: A bibliometric analysis was performed using the Bibliometrix Package in R Software and CiteSpace software.
    RESULTS: The volume of research on TAMs continues to increase, with this study identifying major contributors to the field. The focus of research has shifted from traditional methods, such as flow cytometry and histological techniques, toward single-cell omics approaches, which offer unbiased insights into TAM heterogeneity. Current areas of interest include biomarkers, immune therapies, TAM states, tumor microenvironments, macrophage-targeted agents, and the response of TAMs to therapeutic interventions. These topics are anticipated to remain prominent in the near future.
    CONCLUSION: The study provides an overview of annual publication trends, influential papers, key journals, frequently used keywords, leading authors, and contributing institutions. It also highlights the interdisciplinary evolution of TAM-related research and the connections between these areas of study.
    Keywords:  Bibiliometric study; Citespace; Developmental trends; Hot spots; R software; TAMs
    DOI:  https://doi.org/10.1007/s12672-025-02473-8
  20. Croat Med J. 2025 May 07. 66(2): 153-163
       AIM: To analyze the most influential publications from researchers in medicine at the University of Split in Croatia, as well as their participation in publicly registered clinical trials, to gain insight into medical research excellence in the second largest university in Croatia.
    METHODS: For articles published in the top 5% of journals in 47 medical categories in the Web of Science Core Collection (WoSCC) from 1997, when the School of Medicine became an independent University constituent, to 2022, we analyzed the number of articles in different discipline categories, citations to these articles, and geographical and institutional collaborations. From the public registry ClinicalTrials.gov, we collected the information on the number of clinical trials at the University of Split School of Medicine and/or the University Hospital of Split.
    RESULTS: Authors with a UNIST affiliation published 106 articles in the top 5% journals in 29 out of 59 WoSCC journal categories. The annual publication output significantly increased over the years. Over 80% of the articles were the result of collaboration with the global research community, involving 82 different countries. The total number of citations across these articles was 21 171, with a median of 187.4 citations per article. The first registered clinical trial in the ClinicalTrials.gov registry with a location in Split School of Medicine or the University Hospital of Split was in 1993, with a statistically significant increasing trend over the years. These trials represented 20.6% of all registered trials from Croatia.
    CONCLUSION: The University of Split has been continually increasing its impact in medical research. Bibliometric analysis should be regularly performed to follow the development of medical research at the University, identify new strategic areas for research excellence, support researchers, and attract new researchers and research teams.
  21. Ecol Evol. 2025 May;15(5): e71215
      In pollination ecology research, there is a notable lack of understanding regarding the evolving trends and changes in scientific topics, which hampers the field's ability to address crucial ecological questions. Closing these knowledge gaps is essential for pollination ecologists to protect pollinator populations and their critical ecological roles. To analyze the work of scientists in pollination ecology, we identified researchers through Google Scholar, focusing on those who listed "pollination" or "pollinators" in their profiles. We also analyzed the 40 most-cited papers in pollination ecology by these scientists, each with over 1000 citations, using statistical tests to explore the relationships between citation counts and various influencing factors. We also examined the top 50 most frequently used bi-grams in article titles by these scientists to identify trends in research topics. We identified 223 pollination ecology scientists who collectively authored 14,661 papers, accumulating 1,570,139 citations. On average, each scientist received 7040 citations, with a mean H-index of 32.5. Notably, 67.8% of these citations came from papers where the scientists were not the first author. Analyzing the 40 most-cited papers revealed no significant correlations between citation counts and potential influencing factors. However, 24 of these papers emphasized the global importance of pollinators and their declines. Our trend analysis showed an increase in publications starting around 1974, peaking in 2020, and then declining. Citations have decreased since 2010, likely indicating a shift towards more specialized research topics. The analysis highlights a continued focus on bee research, particularly honeybees (Apis mellifera), within pollination ecology. Despite this focus, there has been a decline in publications since 2020 and in citations since 2010, suggesting the need for diversifying research themes to maintain the field's impact and relevance.
    Keywords:  citation analysis; network analysis; pollination ecology; pollinators; research topics; trend analysis
    DOI:  https://doi.org/10.1002/ece3.71215
  22. Drug Des Devel Ther. 2025 ;19 3589-3610
       Introduction: Venous thromboembolism (VTE) is a leading cause of cardiovascular-related deaths. Non-vitamin K antagonist oral anticoagulants (NOACs) offer effective therapy without injections or blood monitoring. This bibliometric analysis explores the research on NOACs for preventing VTE and pulmonary embolism.
    Methods: Literature up to July 20, 2024, was searched in Web of Science Core Collection. Citespace software was used for screening and analysis.
    Results: In this study, we analyzed 2124 articles and 767 reviews from 11,282 institutions across 528 countries and regions, encompassing 830 publications and 60 research directions. The USA led in publication count, followed by Germany and Canada. Cardiovascular System Cardiology, Hematology, and General Internal Medicine were the top research areas, while THROMBOSIS AND HAEMOSTASIS was the leading journal. From 2004 to 2024, we observed accelerated publication growth, particularly from 2008, highlighting the emergence of NOACs as a major research focus. Key contributors, including Bengt I. Eriksson, and major institutions like Harvard Medical School and University of Amsterdam, played pivotal roles in advancing anticoagulant research. Co-citation and keyword clustering analyses revealed research hotspots in NOACs, cancer-associated venous thromboembolism, stroke prevention, and COVID-19-related thrombotic events, reflecting a shift towards individualized anticoagulation therapy and the growing importance of NOACs in various clinical contexts.
    Conclusion: The development of NOACs has progressed rapidly, with an increasing number of publications, indicating the lead research in the United States and other Western nations. Comparative studies on the safety and efficacy of NOACs have become a significant focus, shifting from traditional anticoagulants. Pharmacogenetics-guided use of NOACS shows new hope of precision medicine.
    Keywords:  bibliometric analysis; non-vitamin K antagonist oral anticoagulants (NOACS); oral anticoagulants; pulmonary embolism; thromboembolism; venous thrombosis
    DOI:  https://doi.org/10.2147/DDDT.S505751
  23. Cureus. 2025 Apr;17(4): e81746
      Neurological symptoms in Sjögren's syndrome (SS) present across a spectrum of severity, posing diagnostic and therapeutic challenges. This bibliometric review adopts a comprehensive approach to analyze the research landscape related to these symptoms. The data source utilized for this bibliometric review was the Web of Science Core Collection. The study selection encompassed English-language articles and reviews published between January 1, 2006, and June 30, 2023. Data extraction involved a systematic analysis of a total of 910 publications, which included 625 research articles and 285 reviews. The publication trends indicate a steady growth in research output, peaking with 122 papers in 2022. Geographic contributions primarily originate from the United States, followed by robust European contributions and increasing input from Asian countries, particularly China and Japan. Influential researchers such as Smith JM from Johns Hopkins University, Brown L from Harvard University, and Wang Q from Peking University have significantly shaped this field. Key institutions driving substantial publication volume and citation impact include Johns Hopkins University, Harvard University, and the University of Tokyo. Furthermore, journals such as Neurology, Journal of Autoimmunity, and Clinical Rheumatology play pivotal roles in disseminating advancements in SS-related neurological research. Future research priorities should focus on primary prevention, emphasizing the need for global cooperation and collaboration in neurological SS workup. There is a call for encouraging interdisciplinary, internationally focused investigative efforts specifically targeting SS neurologists. Key focus areas include potential preventive therapies aimed at significant neural dysfunctions (e.g., sensory neuropathy), mechanisms of microvascular dysfunction, and cognitive profiles/immunomodulation against autoantibodies. This analysis underscores the continued necessity for further research to optimize diagnosis and treatment in cases involving the complexities of neurological involvement with SS.
    Keywords:  autoimmune mechanisms; cognitive dysfunction; neurological symptoms; peripheral neuropathy; sjögren's syndrome
    DOI:  https://doi.org/10.7759/cureus.81746
  24. Medicine (Baltimore). 2025 May 02. 104(18): e41945
      Isodon rubescens has been used as an herbal medicine in China for a long time. The significant value of development and utilization is affirmative. Bibliometrics is used as an approach to sort out, analyze, and visualize relevant literature in a particular field. So, it can intuitively express the research trends, hot directions, significant achievements, core journals, and outstanding authors in the field. But there is no bibliometrics analysis of I rubescens. The relevant dataset was retrieved and exported from the Web of Science database, and the results were obtained and visualized using the R Programming Language, CiteSpace, and VOSviewer, with the creation of time zone maps also using Scimago Graphica and Gephi. There were 506 valid data retrieved and 465 analyzed data selected. The country with the most significant number of publications is China, the institution with the largest annual publication volume is China Pharmaceutical University, the publication with the most relevant literature is the International Journal of Oncology, and the author with the most publications is Zhou. The keyword with the greatest intensity is "matastasis," which is also an emerging keyword. The role of I rubescens has been continuously diversifying. It has been proven to play a role in treating major diseases such as multiple cancers, leukemia, liver and kidney function impairment, and cardiovascular and cerebrovascular diseases. This study will highlight the main research direction in this field, namely the use of I rubescens for the treatment of cancer.
    Keywords:  ; VOSviwer; bibliometrics; citespace; the R programming language
    DOI:  https://doi.org/10.1097/MD.0000000000041945
  25. J Bodyw Mov Ther. 2025 Jun;pii: S1360-8592(25)00077-4. [Epub ahead of print]42 894-901
       BACKGROUND: Diabetic cardiomyopathy (DCM) is a severe outcome of type 2 diabetes mellitus (T2DM) and a major global health concern. The overall impact of T2DM on the heart is demonstrated by echocardiographic measurements. Exercise helps reduce cardiovascular disease risk and improves glycemic management in T2DM. The objective of the present bibliometric study was to map the research trends on left ventricular dysfunction and exercise among T2DM.
    MATERIALS AND METHODS: The comprehensive search was conducted in the SCOPUS database, with the keywords "type 2 diabetes", "diabetic cardiomyopathy", "exercise," and "left ventricular function", with BOOLEAN Operators AND, OR. The search period ranged from 1984 to November 2023. The data was exported to VOS Viewer(1.6.20) for analysis.
    RESULTS: Sixty-nine documents were retrieved from the database search. A steady rise was observed in the number of documents per year, between 1 and 5. The following countries published the maximum number of documents: the USA, Italy, Australia, and the UK. 79.7% of documents were original articles, 18.8% were reviews, and 1.4% were editorials. Most studies belonged to categories, namely medicine(69.9%), biochemistry(15.1%), pharmacology (8.6%) and health professions (2.2%). The network analysis was performed to explore the association between the studies based on co-authorship, citation analysis, and co-occurrence.
    CONCLUSION: The bibliometric analysis showed the maximum number of publications belonged to high-income countries, with smaller contributions from low-middle-income countries (LMICs), including the Indian subcontinent. There is a need to explore the area of exercise and left ventricular dysfunction in T2DM as exercise can act as a valuable tool in LMICs where the burden of T2DM is increasing.
    Keywords:  Diabetic heart disease; Exercise training; Left ventricle; Type 2 diabetes
    DOI:  https://doi.org/10.1016/j.jbmt.2025.02.017
  26. Discov Oncol. 2025 May 08. 16(1): 700
      Breast cancer remains a significant global health challenge, with lung metastasis presenting critical barriers to effective treatment and patient survival. This study conducts the first comprehensive bibliometric and visualized analysis of lung metastasis research in breast cancer from 2000 to 2024, illustrating evolving research trends and collaboration patterns in this critical area. Utilizing data from the Web of Science Core Collection, we employed bibliometric tools such as VOSviewer and CiteSpace to assess publication trends, international collaborations, influential institutions, authors, and keyword dynamics. Our findings reveal a steady increase in annual publications, peaking in 2021, with a significant concentration of research emerging from the USA and China, alongside key insights into molecular mechanisms such as epithelial-mesenchymal transition and immunotherapy. Notably, genes like ERBB2 and ESR1 were identified as pivotal in the metastatic process, highlighting potential therapeutic targets. This study not only illuminates the current landscape of breast cancer lung metastasis research but also underscores the necessity for interdisciplinary collaboration to enhance understanding and treatment strategies for this lethal condition.
    DOI:  https://doi.org/10.1007/s12672-025-02496-1
  27. Front Psychiatry. 2025 ;16 1522299
       Objective: The aim of this study was to analyze the research hotspots and frontiers in the field of autistic traits (AT) between 1997 and 2024.
    Methods: The Web of Science Core Collection (WOSCC) is used as a data source in the study, analyzing 1,044 academic articles on AT published between 1997 and 2024. The included articles were visually analyzed using CiteSpace 6.2.R4 software, which is used to map keywords and core literature related to AT and to analyze research progress and emerging hotspots in the field.
    Results: A total of 1,044 articles have been included in the analysis, and the total number of articles has demonstrated an upward trajectory. The nations of England, the USA, and Australia are at the vanguard of this body of literature. With regard to research institutions, the University of London has attracted considerable attention as a result of its substantial contributions to the field of AT. The most relevant research is published in the Journal of Autism and Developmental Disorders.
    Conclusion: The scope of AT research has expanded considerably, encompassing psychology, education, and other disciplines. The research dimensions extend beyond behavioral, genetic, cognitive, and neural aspects to include environmental and hormonal factors. Furthermore, the study population has evolved from twins and the general population to focus on specific groups, such as individuals with psychiatric disorders. This broadening of focus has led to a significant increase in AT research in recent years. In sum, this study provides a comprehensive perspective that can inform and guide further in-depth research on AT.
    Keywords:  (WOS) web of Science; Citespace; autism spectrum disorder; autistic traits; visual analysis
    DOI:  https://doi.org/10.3389/fpsyt.2025.1522299
  28. Biomed Res Int. 2025 ;2025 5086946
      Background: The global burden of cancer necessitates innovative approaches to its management and treatment. Traditional treatments like radiotherapy, immunotherapy, surgery, and chemotherapy, carry significant side effects that impact patient quality of life. Dietary fiber has attracted research interest as a potential mitigator of cancer progression and a supportive agent in cancer treatment. This bibliometric study analyzes trends in research connecting dietary fiber, cancer therapy, and gut health from April 1999 to May 2024. Methods and Results: Web of Science, PubMed, and Scopus databases were used to retrieve peer-reviewed publications from April 1999 to May 2024 on dietary fiber and cancer management. The study identifies a rising scholarly interest in dietary fiber's role in cancer management, focusing significantly on the interactions between dietary fiber and gut microbiota. These interactions are particularly noted for their influence on inflammation and cancer metastasis. The study highlights evolving research themes, the importance of specific fiber types in cancer progression, and highlights persistent foundational themes like glycosylation. Emerging areas include personalized nutrition and innovative therapeutic approaches. The geographical and institutional contributions, mainly from the United States and China, underline the significance of collaborative and interdisciplinary efforts in advancing research. Conclusion: This analysis emphasizes integrating dietary strategies in comprehensive cancer care and aims to address research gaps to develop more effective and patient-centered cancer therapy and prevention strategies.
    Keywords:  bibliometric analysis; cancer management; chemotherapy; dietary fiber; immunotherapy; radiotherapy
    DOI:  https://doi.org/10.1155/bmri/5086946
  29. Front Immunol. 2025 ;16 1525462
       Objective: Autoimmune diseases have long been recognized for their intricate nature and elusive mechanisms, presenting significant challenges in both diagnosis and treatment. The advent of artificial intelligence technology has opened up new possibilities for understanding, diagnosing, predicting, and managing autoimmune disorders. This study aims to explore the current state and emerging trends in the field through bibliometric analysis, providing guidance for future research directions.
    Methods: The study employed the Web of Science Core Collection database for data acquisition and performed bibliometric analysis using CiteSpace, HistCite Pro, and VOSviewer.
    Results: Over the past two decades, 1,695 publications emerged in this research field, including 1,409 research articles and 286 reviews. This investigation unveils the global development landscape predominantly led by the United States and China. The research identifies key institutions, such as Brigham & Women's Hospital, influential journals like the Annals of the Rheumatic Diseases, distinguished authors including Katherine P. Liao, and pivotal articles. It visually maps out the research clusters' evolutionary path over time and explores their applications in patient identification, risk factors, prognosis assessment, diagnosis, classification of disease subtypes, monitoring and decision support, and drug discovery.
    Conclusion: AI is increasingly recognized for its potential in the field of autoimmune diseases, yet it continues to face numerous challenges, including insufficient model validation and difficulties in data integration and computational power. Significant advancements have been demanded to enhance diagnostic precision, improve treatment methodologies, and establish robust frameworks for data protection, thereby facilitating more effective management of these complex conditions.
    Keywords:  artificial intelligence; autoimmune diseases; bibliometric exploration; content analysis; forefront
    DOI:  https://doi.org/10.3389/fimmu.2025.1525462
  30. J Burn Care Res. 2025 May 04. pii: iraf072. [Epub ahead of print]
      Evidence-based burn surgery and management rely on high-quality research to inform practice and policy. However, burn surgical research is costly, and the distribution of American Burn Association (ABA)-verified burn centers is unequal. This study examines the relationship between research funding, productivity, and ABA-verification in burn surgery. PubMed was queried for all burn surgery/reconstruction articles, collecting data on article title, funding, type, and affiliation. ABA-verified burn centers and their academic affiliations were identified via the ABA website and Google search. The query identified 16,138 burn surgery articles, with 3001 affiliated with US institutions and published in 1,785 journals. Notable journals include Burns (n=2,992) and Journal of Burn Care and Research (n=1,558). Only 16.6% of articles reported grant funding, primarily from non-U.S. government sources. High-level evidence (clinical trials and systematic reviews/meta-analyses) comprised 2.7% of articles but were more likely to be funded (32.4% vs. 16.1%, p<0.001). Articles from ABA-verified centers represented 13.5% of publications and were significantly more likely to receive funding (30.5% vs. 14.4%, p<0.001). ABA affiliation doubled the odds of research funding (OR: 2.014, p<0.001), and U.S.-based institutional affiliation increased funding odds by 122.8% (OR: 2.228, p<0.001). High level evidence comprises a minority of articles in burn surgery literature but are significantly associated with research funding. Furthermore, ABA-verified burn centers have a higher percentage of their research funded. While we are unable to elucidate whether ABA verification or research funding drives this phenomenon, it remains clear that high level burn surgery research, funding, and ABA-verification often coexist.
    Keywords:  ABA; American burn association; bibliometric; burn; burn surgery
    DOI:  https://doi.org/10.1093/jbcr/iraf072
  31. Se Pu. 2025 May;43(5): 498-507
      Exosomes are extracellular vesicles secreted by cells and are rich in genetic material and proteins. The surfaces of exosome membranes contain many blast-specific markers that provide an important basis for disease diagnosis, progression, and treatment. Herein, we searched the Web of Science core collection (SCI-EXPENED) database for research and review articles on "exosomes" and "biomarkers" or "diagnostics" or "liquid biopsy" as research topics between 2010 and 2024. Bibliometric analysis revealed that exosomes have received increasing levels of attention as disease biomarkers, with China contributing the most to these studies. Herein, we focus on marker diagnoses for cancer, inflammation, and diabetes, as well as neurodegenerative and cardiovascular diseases. Chromatography, mass spectrometry, Raman spectroscopy, and other techniques are typically used to analyze exosomal nucleic acids, proteins, and metabolites, with commonly used test samples including plasma, serum, urine, saliva, cerebrospinal fluid, and other bodily fluids. Research into exosomes as tumor markers has mainly focused on eight highly prevalent cancers, including lung, breast, and prostate cancers. This paper focuses on exosomes as disease biomarkers and uses a bibliometric tool system to analyze the use of exosomes and their contents as biomarkers in the disease diagnosis field between 2010 and 2024, analyzes development prospects, and discusses future exosome-mediated efforts for diagnosing and treating diseases, and is expected to provide a reference for studying and applying exosomes as disease markers.
    Keywords:  bibliometric analysis; biomarkers; disease diagnosis; exosomes; liquid biopsy
    DOI:  https://doi.org/10.3724/SP.J.1123.2025.01025
  32. J Multidiscip Healthc. 2025 ;18 2497-2508
       Background: Medical errors represent a critical challenge to global healthcare systems, ranking among the leading causes of preventable morbidity and mortality. The aim of this study was to explore the evolution, characteristics, and correlation of research on medical errors and global health and research indicators.
    Methods: A mixed-methods scientometrics study was conducted to analyse publications from 1865 to 2024 on medical errors from five databases. Correlational analyses were performed, focusing on publication trends, geographic and economic disparities, journal metrics, and thematic evolution. Multiple regression assessed relationships between bibliometric metrics and global indicators.
    Results: Five thousand seven hundred thirty-two publications related to medical errors were analysed. An annual growth rate of 1.49% was documented, with high-income countries contributing 83.32% of publications. The Americas accounted for the highest regional output, while Africa and Southeast Asia showed marginal contributions. Most studies were published in high-impact journals (46% in Q1), but only 22.98% were open access. Thematic analysis revealed a transition from error reporting to mitigation strategies. Correlations showed strong associations between intellectual property fees and publication volume (r²=0.75; p<0.001), while official development assistance negatively correlated with publication output (r²=-0.33; p<0.01). Disability-adjusted life years showed weak correlations with publication volume (r²=0.32; p<0.01) and journal impact (r²=0.14; p<0.001).
    Conclusion: This study highlights significant inequities in global research on medical errors, with high-income countries dominating production. While thematic shifts suggest advancements in the field, the lack of representation from low- and middle-income countries and limited access to open-access publications pose barriers to global applicability.
    Keywords:  bibliometrics; global health; health care quality indicators; health services; medical errors; meta-research
    DOI:  https://doi.org/10.2147/JMDH.S516383
  33. Inquiry. 2025 Jan-Dec;62:62 469580251333308
      With the rapid aging of populations worldwide, the role of daycare centers in supporting older adults' well-being has gained unprecedented attention. Despite the growing body of research in this area, systematic reviews focusing on high-quality literature remain scarce. This study aims to address this gap by providing an in-depth analysis of the existing literature on adult daycare centers. This study bridges this gap by conducting a 33-year bibliometric analysis of 853 publications from the Web of Science database (1990-2023), using VOSviewer, CiteSpace, and Biblioshiny. Through the analysis of countries and authors, it was found that research in this field is predominantly concentrated in regions such as North America, Asia, and Europe. Keyword analysis revealed 3 main research themes in the field of adult daycare centers: "physical and mental diseases," "rehabilitative care," and "social support." There is a lack of comprehensive and systematic evaluation frameworks in the research on the architectural design and facilities of adult daycare centers. Meanwhile, the study highlights 3 key aspects for improving the design and facilities of adult daycare centers: (1) addressing the physical and psychological needs of the older adults, (2) enhancing rehabilitative care facilities, and (3) focusing on the needs of caregivers. This study not only maps research trends but also provides actionable directions for policymakers and practitioners to create more inclusive and effective older adult daycare support systems in response to the aging population.
    Keywords:  adult daycare centers; and mental diseases; bibliometric analysis; physical; rehabilitative care; scoping review; social support
    DOI:  https://doi.org/10.1177/00469580251333308
  34. Plast Surg (Oakv). 2025 May 05. 22925503251333387
      Introduction: Research is an important component of medical student applications to plastic surgery residency. However, little is known about institution-level factors that may influence research productivity among plastic surgery applicants and how productivity during medical school impacts research output during residency. Methods: Plastic surgeons who graduated from an integrated plastic surgery residency program in the United States and obtained board certification between 2020 and 2022 were included in the study. Website profiles were used to obtain medical school and residency training information, and the National Institutes of Health (NIH) iCite database was utilized to identify publications during medical school and residency training. Linear regression was performed to assess the correlation between research productivity during medical school and residency. Unpaired t tests were performed to compare the mean number of publications between medical students. Results: A total of 277 plastic surgeons were included in the analysis. The mean number of publications during medical school and residency was 3 and 8.7, respectively. The number of first-author publications during medical school had the strongest correlation with total research output during residency (r 2 = 0.23, P < .0001). Students at schools with plastic surgery residency programs (3.29 vs 1.56, P < .0001) and students from top 40 NIH-funded medical schools (4.44 vs 1.84, P < .0001) had significantly more publications than their peers. Conclusion: First-author publications during medical school may be the strongest predictor of productivity during residency. Students at schools without affiliated plastic surgery residency programs may have fewer opportunities to participate in scholarly activity.
    Keywords:  medical student; plastic surgery; publications; research; residency
    DOI:  https://doi.org/10.1177/22925503251333387
  35. Spine J. 2025 May 07. pii: S1529-9430(25)00247-5. [Epub ahead of print]
       BACKGROUND CONTEXT: There is limited information on spine society presidents' training backgrounds, academic productivity, and demographics. This is crucial because the individuals elected to this role are thought leaders and can impact the future trajectory of spine surgery.
    PURPOSE: To characterize the training backgrounds, academic productivity, and demographics of presidents elected to serve in seven spine societies: Scoliosis Research Society (SRS), Cervical Spine Research Society (CSRS), North American Spine Society (NASS), Lumbar Spine Research Society (LSRS), International Society for the Study of the Lumbar Spine (ISSLS), American Association of Neurological Surgeons Spine (AANS Spine) and International Society for the Advancement of Spine Surgery (ISASS).
    STUDY DESIGN/SETTING: Retrospective Cohort Study.
    OUTCOME MEASURES: Training backgrounds, academic productivity, and demographics of spine societies presidents.
    METHODS: This was a retrospective cohort study of seven spine society presidents (n=156) from 2000 to 2024. The information was retrieved via society websites for the SRS (n=24), CRSR (n=25), NASS (n=25), (n=25), ISSLS (n=25), AANS Spine (n=25), and ISASS (n=23). LSRS provided their list of presidents (n=9) upon request. Training backgrounds, current academic productivity, and demographic characteristics were obtained from online curriculum vitae, academic websites and Scopus. Data collection occurred from 06/19/2024 to 09/14/2024.
    RESULTS: Most presidents (95.5%) were surgical providers (orthopaedic surgeons 106/156,67.9%; 43/156, 27.6% neurosurgeons). Only 7/156 (4.5%) were non-surgical providers. CSRS and SRS presidents had the highest cumulative publications and H-index, respectively. The academic rank at appointment was professor for 122/156 (78.2%) presidents. Of the 156 presidents, 12.9% were MD/PhDs. There were 150/156 males (96.2%), and 122/156 were white (78.2%).
    CONCLUSION: Spine society presidents are mostly male orthopaedic surgeons with high scholarly output. Most had the academic rank of professor. As orthopaedic and neurosurgery training programs become more representative of the population, more leaders from diverse backgrounds may become future presidents of these societies.
    Keywords:  academic medicine; demographics; gender; leadership; research; residency training; spine societies; spine surgery
    DOI:  https://doi.org/10.1016/j.spinee.2025.05.019
  36. JSES Rev Rep Tech. 2025 May;5(2): 270-275
       Background: While previous studies have examined trends in industry funding among orthopedic surgeons across various subspecialties, there is limited research focusing on institutional-level evaluations. The purpose of this study was to investigate the relationship between shoulder and elbow surgery fellowship program characteristics and industry payments.
    Methods: This cross-sectional analysis examined characteristics of shoulder and elbow surgery fellowship programs, including program reputation, academic productivity metrics, region of practice, and total number of fellows, in relation to industry lifetime earnings as of March 2024. Fellowship faculty were identified from the American Shoulder and Elbow Surgeons (ASES) directory, while program data were collected from individual program websites. All ASES fellowship faculty members were confirmed on individual program websites. Each surgeon was searched on the Open Payments Database for their compensation earnings. Prestige factors, including fellowship-affiliated residency rankings, were gathered from Doximity and Newsweek rankings, respectively. Academic productivity metrics, including the Hirsch index (H-index), M-index, Relative Citation Ratio (RCR), weighted RCR, and attending publication rates, were obtained using iCite, Scopus, and ResearchGate databases.
    Results: We identified 151 ASES fellowship faculty members, including 145 male faculty members and 5 female faculty members, from 34 shoulder and elbow surgery fellowship programs. The mean number of payments per fellowship was 999.32 ± 687.51, resulting in mean fellowship lifetime earnings of $1,125,924.05 ± $1,788,302.048. The top sources of industry funding included royalties ($ 766,904.11 ± $765,382.42; 77.3%) followed by consulting ($163,148.43 ± $337,926.35; 15.8%). While there was a statistically significant increase in total lifetime earnings in fellowship programs associated with a Newsweek ranking of the fellowship-affiliated hospital (Kruskal-Wallis, H = 10.806, P = .029), there were no significant correlations between total lifetime fellowship earnings with the Doximity ranking of fellowship-affiliated residency programs (P = .600), region of the United States (P = .129), the number of fellows per program (P = .139), practice type (academic vs. private; P = .287), or academic productivity metrics (fellowship H-index [P = .203], M-index [P = .408], RCR [P = .844], weighted RCR [P = .385], attending publication rate [P = .140]).
    Conclusion: Our findings indicate that institutional prestige influences industry funding among ASES shoulder and elbow surgery fellowship programs irrespective of academic productivity metrics. Further investigation of this correlation is warranted to better inform policies aimed at promoting transparency and ethical considerations within medical education. By identifying these influences, future studies can help to refine guidelines that govern interactions between industry and medical professionals, ultimately supporting integrity and transparency in medical education and practice.
    Keywords:  Academic productivity; Doximity; Fellowships; Newsweek; Open Payments; Orthopedic surgery; Shoulder and elbow; Sunshine Act
    DOI:  https://doi.org/10.1016/j.xrrt.2024.12.014
  37. J Craniomaxillofac Surg. 2025 May 04. pii: S1010-5182(25)00135-0. [Epub ahead of print]
      In maxillofacial surgery literature, where innovation drives advancements in techniques and patient care, citations are particularly critical. The aim of this paper is to retrospectively review the correlation between various parameters and the number of citations. This study analyzed 47,572 articles across nine high-impact journals to identify evidence-based strategies for increasing citation counts. A separate bibliographic search on citation-boosting strategies included 109 articles, of which 24 met the inclusion criteria. Statistical analyses included Pearson's correlation, odds ratios, Chi-square tests, and linear regression, performed using RStudio. Key findings indicated that articles with four authors were cited significantly more often (OR = 2.31, 95 % CI: 1.89-2.74, p < 0.001). Titles with approximately 13 words optimized visibility (p = 0.007), and articles around six pages in length balanced depth and readability (p = 0.012). Regression analyses showed that colons in titles positively influenced citation rates (β = 1.42, p < 0.001), while hyphens had a weaker or negative impact in high-impact journals (β = -0.85, p = 0.039). English was the dominant language in maxillofacial surgery literature (99.36 %). Reviews were cited 2.5 times more often than original research articles (p < 0.001). This study highlights actionable strategies to boost citations in maxillofacial surgery literature, leveraging a meta-data science approach to provide evidence-based recommendations. However, it should be clear that statistical analyses do not imply causation, and these recommendations should not be considered a definitive guide to boosting citations.
    Keywords:  Bibliometrics; Citations; Maxillofacial injuries; Orthognathic surgery
    DOI:  https://doi.org/10.1016/j.jcms.2025.04.007
  38. Discov Oncol. 2025 May 08. 16(1): 702
       BACKGROUND: Nucleic acid probes, which are short sequences of nucleic acids designed to complement specific DNA or RNA targets, have broad applications in biosensing, genetic studies, and various other fields. In tumor diagnosis and treatment, nucleic acid probes offer a precise and accessible approach that is essential for improving patient care and quality of life. Despite substantial research on nucleic acid probes over the past three decades, few comprehensive reviews have retrospectively examined the field.
    METHODS: This study extracted 30 years of nucleic acid probe-related research articles from the Web of Science Core Collection database. We used CiteSpace, VOSviewer, and R tools to systematically analyze the field's current status and developmental trends, with an emphasis on applications in oncology.
    RESULTS: Our findings indicate a continuous growth trend in nucleic acid probe research, with the United States and China, along with their leading institutions and authors, making the most significant contributions. In oncology specifically, nucleic acid probe research has focused primarily on signal amplification, liquid biopsy, and drug delivery. The emergence of novel biomarkers and assay techniques has been a pivotal factor driving advancements in this field.
    CONCLUSION: Nucleic acid probes show strong potential for applications in tumor precise diagnosis and treatment. Continued innovation and closer interdisciplinary collaboration will be vital for further advancements, while large-scale clinical studies are needed to validate their clinical utility.
    Keywords:  Bibliometric analysis; Biosensor; DNA; Nucleic acid probe; Oncology; RNA
    DOI:  https://doi.org/10.1007/s12672-025-02478-3
  39. Curr Opin Psychol. 2025 Apr 26. pii: S2352-250X(25)00058-2. [Epub ahead of print]65 102045
      There is a need to find solutions to the current environmental crises, some of which require behavioral change. Psychological research is increasingly needed to understand the relationship between human communities and nature. The present review aims to gain insights into the current and emerging research trends on community and nature to understand the different approaches psychologists use to address the current social and environmental challenges. This was done in Scopus through a bibliometric analysis of published literature from January 2020 to November 2024. According to our analysis, there is an increment in publications involving several countries and sources, not all of which are directly related to psychology publications. Science mapping of keyword co-occurrence was used to identify the current trends. The publications were grouped in six main trends that encompass conservation and sustainability, pro-environmental behaviors, connectedness to nature, ecosystem services and greenspaces, nature-society relations, and impact assessments. Identifying these trends helps us to direct future research on the need to understand the interaction between communities and nature to solve both the social and environmental problems we are facing today, which will have an impact on the future of our planet.
    DOI:  https://doi.org/10.1016/j.copsyc.2025.102045
  40. Naunyn Schmiedebergs Arch Pharmacol. 2025 May 06.
      Since the onset of the COVID-19 pandemic in March 2020, researchers worldwide have sought effective drugs to prevent and manage SARS-CoV-2 and its spectrum of symptoms. Ivermectin, originally developed as an anthelmintic for controlling parasitic infections in humans and animals, has drawn attention based on the hypothesis that it inhibits viral replication. In Austria, ivermectin usage peaked in November 2021, following promotion by the right-wing Freedom Party of Austria (FPÖ) as an alternative treatment to vaccination, resonating strongly within anti-vaccine and skeptical communities. The topic is also very present in the United States of America due to the re-election of D. Trump as US President and the designation of R. Kennedy as the United States' Secretary of Health and Human Services. To critically examine the controversial use of ivermectin for COVID-19 and publication trends during the pandemic, this study analysed all publications listed in PubMed from 1 January 2020 to 31 December 2022 using the keywords 'ivermectin' and 'COVID-19', resulting in a dataset of 353 publications. These publications were assessed for scientific quality, methodological rigour and bias, with particular focus on the influence of social and political dynamics on publication practices, as well as the prevalence of preprints, citation trends and the role of funding sources. Our study shows that many highly cited studies on ivermectin display methodological weaknesses and data gaps, contributing to the propagation of hypotheses lacking substantial empirical support. This analysis underscores the necessity of rigorous quality control during crises and highlights the long-term risks posed to scientific databases and public health by methodologically deficient research.
    Keywords:  Antiviral treatment; COVID-19; Citation analysis; Drug repurposing; Evidence-based medicine; Ivermectin; Methodological bias; Pandemic; Preprints; SARS-CoV-2
    DOI:  https://doi.org/10.1007/s00210-025-04233-5
  41. Naunyn Schmiedebergs Arch Pharmacol. 2025 May 09.
      The primary objective of this study is to analyze the number of Deutsche Forschungsgemeinschaft (DFG)-sponsored papers published in Naunyn-Schmiedeberg's Archives of Pharmacology (NSAP), the oldest pharmacology journal in the world. This is the first systematic investigation of DFG-sponsored research in NSAP. Using the Scopus database, which provides comprehensive citation data from 1969 onward (for NSAP), the study identifies DFG-sponsored publications in the fields of pharmacology, toxicology, and pharmaceutics. The analysis includes only peer-reviewed articles and reviews, excluding other document types such as conference proceedings or editorials etc. The results show that, out of 453,047 total DFG-sponsored publications from 1969 to the present, only 3.05% (13,847) are in the specialized fields of pharmacology, toxicology, and pharmaceutics. This is relatively low compared to other research areas such as biochemistry, genetics, and molecular biology (24.69%), and physics and astronomy (23.37%). The study further analyzes the yearly publication dynamics of DFG-sponsored papers in NSAP, revealing a concerning trend: between 2015 and 2023, fewer than 10 DFG-sponsored papers were published in each of these years, with the lowest being 2 publications in 2022. These findings raise questions regarding the visibility and contribution of DFG-funded research in NSAP and suggest that strategies could be developed to enhance the presence of DFG-sponsored research in this historically significant journal. The study does not aim to interfere with funding policies but encourages a discussion on ways to improve publication outcomes for DFG-sponsored projects, particularly in well-established journals like NSAP. Collaboration between researchers, universities, and funding bodies may be key to promoting the visibility and impact of DFG-funded research in relevant academic journals.
    Keywords:  Deutsche forschungsgemeinschaft; Naunyn–Schmiedeberg’s Archives of Pharmacology; Pharmacology research; Publication analysis; Research funding; Scopus
    DOI:  https://doi.org/10.1007/s00210-025-04254-0
  42. Data Brief. 2025 Jun;60 111535
      There has been a recent push to make public, aggregate, and increase coverage of bibliographic citation data. Here we describe uCite, a citation dataset containing 564 million PubMed citation pairs aggregated from the following nine sources: PubMed Central, iCite, OpenCitations, Dimensions, Microsoft Academic Graph, Aminer, Semantic Scholar, Lens, and OpCitance. Of these, 51 million (9%) were labeled unreliable, as determined by patterns of source discrepancies explained by ambiguous metadata, crosswalk, and typographical errors, citing future publications, and multi-paper documents. Each source contributes to improved coverage and reliability, but varies dramatically in precision and recall, estimates of which are contrasted with the Web of Science and Scopus herein.
    Keywords:  Bibliographic database; Citation data; Citation errors
    DOI:  https://doi.org/10.1016/j.dib.2025.111535
  43. Environ Res. 2025 May 05. pii: S0013-9351(25)01032-1. [Epub ahead of print] 121781
      Constructed wetlands (CWs) can be used for water purification and ecological restoration through the synergistic effects of substrates, aquatic plants, and microorganisms. This study explored a bibliometric approach to quantitatively evaluate the recent research progress and applications of CWs in China by synthetically analyzing publication output characteristics, research hotspots and quantified China's unique contributions to global CW applications. The results indicated that the number of papers published in the field of CWs has shown an overall upward trend in the past two decades, and the research hotspots mainly focus on the nitrogen and phosphorus removal, microbial community. China has actively supported the investigation and application of CWs for wastewater treatment and reuse. More than 40 species of plants and over 30 types of substrates have been employed in CWs for treating different types of wastewater, such as domestic sewage, industrial effluents, river water, and drinking water. Several successful case studies of full-scale CWs have been selected and summarized to highlight the extensive application of CWs in China and provided a CW localized design framework.
    Keywords:  Bibliometric analysis; Case studies; Constructed wetland; Wastewater; Wetland plants
    DOI:  https://doi.org/10.1016/j.envres.2025.121781
  44. Value Health. 2025 May;pii: S1098-3015(25)00084-1. [Epub ahead of print]28(5): 671-675
       OBJECTIVES: The aim of this study was to report women's authorship in Value in Health in terms of articles submitted to and accepted for publication before and during the COVID-19 pandemic to evaluate its potential impact on women's research productivity.
    METHODS: The proportion of women corresponding and first authors among submitted and accepted articles were analyzed and compared between the 2 periods: before (2018-2019) and during the COVID pandemic (2020-2021). The proportion of women corresponding authors from low- and middle-income countries (LMIC) was compared with the proportion from the rest of world (ROW).
    RESULTS: A total of 4910 Value in Health submissions were identified from 2018 to 2021. The proportion of women's first and corresponding authorship of articles submitted to and accepted for publication in Value in Health slightly increased from before the pandemic to during the pandemic, although not statistically significantly. The difference in proportions of women corresponding authors between LMIC and ROW countries was statistically significant for both periods: before and during the pandemic. Logistic regression models determined that submissions from ROW countries have an increased odds of women corresponding authorship than submissions from LMIC countries (OR 1.28; 95% CI 1.11-1.46).
    CONCLUSIONS: Findings from this study suggest that the pandemic did not exert an adverse effect on women submitting to or publishing articles in Value in Health. Additional studies are needed to explore whether the proportions are representative of the workforce and investigate whether these distributions change in the future.
    Keywords:  gender study; research productivity; women authorship
    DOI:  https://doi.org/10.1016/j.jval.2025.02.006
  45. Medicine (Baltimore). 2025 May 02. 104(18): e42230
      Osteoarthritis (OA) is one of the common chronic arthritis in middle-aged and elderly people, but the effect of lipid metabolism on OA is still unclear. The aim of this study was to explore the value of lipid metabolism markers as emerging biomarkers for assessing OA disease activity. The literature on OA and lipid metabolism indicators was extensively analyzed by bibliometric. Correlation analysis was used to analyze the correlation between lipid profile indicators (total cholesterol; triglycerides [TG]; high density lipoprotein cholesterol [HDL-C]; and low density lipoprotein cholesterol) and immunoinflammatory indicators (high sensitivity C-reactive protein; erythrocyte sedimentation rate [ESR]) in patients with OA as well as the disease activity level (visual analog scale (VAS). Logistic regression modeling was used to calculate univariate and multivariate factors of disease activity. A total of 843 papers were retrieved. China and the United States are the 2 most productive countries in this field, and the United States has the highest H-index. In addition, Osteoarthritis and Cartilage is the most published journal. OA lipid metabolism research has long focused on inflammation, lipid metabolism, and pain. The levels of inflammation (ESR, high sensitivity C-reactive protein) and lipid metabolism indicators (total cholesterol; TG, HDL-C) were significantly increased in OA patients. Inflammation indicators were significantly correlated with lipid metabolism indicators. In addition, HDL-C, ESR, and TG were identified as independent influencing factors for OA-VAS. In summary, the role of lipid metabolism in OA has been a hot topic. Markers of inflammation and lipid metabolism were independent influencing factors of OA-VAS.
    Keywords:  bibliometrics; inflammation indicators; lipid metabolism indicators; osteoarthritis
    DOI:  https://doi.org/10.1097/MD.0000000000042230
  46. Emergencias. 2025 Apr;37(2): 117-130
       OBJECTIVE: To analyze the scientific output of professionals working in emergency medicine in Spain during the 2015-2019 vs the previous 5 years (2010-2014).
    METHODS: We included documents authored by professionals affiliated with emergency and urgency medicine in a Spanish center, indexed in the Science Citation Index (SCI)-Expanded, excluding conference communications. These documents were analyzed by publication year, authors (number, affiliation, and order of authorship), journal, document type, and research areas. Some output markers were analyzed by autonomous community and hospital based on the affiliation of the lead author from the emergency settins.
    RESULTS: During the 2015-2019 5-year period, a total of 1,906 documents were published (64% original articles, 33% more vs 2010-2014), with a higher proportion of articles being published in Spanish (55%) vs English (45%). However, there was a significant increase in English articles vs the previous period (32%, p .001). Although most research activity came from hospital emergency departments (85%), the production from emergency medical services (EMS) professionals went up from 8.7% to 11.5%; p .001. First authorship went down from 67% to 50%; p .001, while university affiliation went up from 16% to 33%, p .001, as well as collaborative articles with other hospital and EDs, and other hospitals, including international collaborations (20% of international documents) (p .001 forall comparisons). Research areas with the most documents being published were cardiovascular (17.6%), infectious diseases (11.9%), pediatrics (10.7%), toxicology/pharmacology (8.0%), neurology (5.5%), and pulmonology (5.2%). Catalonia produced the most documents (510; 26.9%), followed by Madrid (419; 22.1%) and Andalusia (281; 14.8%). The regions with the largest relative increase in their share of Spanish output vs the previous 5-year period were Murcia (+71%), the Balearic Islands (+60%), Madrid (+40%), Castile-León (+37%), the Basque Country (+28%), and Asturias (+27%). Hospital Clínic led hospital production (199 out of 1,612 documents; 12%) while the Andalusian EMS led the out-of-hospital production (41 out of 219; 19%).
    CONCLUSIONS: The scientific oyutput of emergency professionals in Spain grew steadily during the 2015-2019 period, with significant positive changes in many qualitative aspects of this production vs the previous 5 years. Some significant changes were also detected regarding the relative weight of certain centers and autonomous communities in this production.
    Keywords:  Bibliometrics; Bibliometría; Emergency and Urgency Medicine; Emergency medical services; Hospital Emergency Services; Investigación; Medicina de Urgencias y Emergencias; Research; Servicios de urgencias hospitalarios; Sistemas de emergencias médicas
    DOI:  https://doi.org/10.55633/s3me/011.2025
  47. Front Oral Health. 2025 ;6 1584382
       Introduction: There are multiple portrayals of dentists and teeth in movies. It is largely unclear if the literature has investigated these portrayals. This literature review aimed to identify and analyze the themes, narratives, and symbolic meanings associated with dental portrayal in movies from the existing literature.
    Methods: Online literature databases, Web of Science, Scopus, and PubMed, were searched to identify relevant papers labelled as articles or reviews. Publications were included if they described or investigated the portrayal of dentists or teeth in multiple commercial movies. Publications were excluded if they were irrelevant to this topic or provided commentary on a single movie only. Finally, 7 publications were identified and reviewed. For each publication, its study design, data source, and genres of movies analyzed were recorded. Key findings were reviewed, such as themes or stereotypes identified, positive vs. negative portrayals, and any impact on public perception elaborated.
    Results: These papers were published between 2007 and 2024. Five of them provided qualitative content analysis, whereas 2 provided quantitative content analysis. Three publications consulted Internet Movie Database (IMDb) to identify relevant movies. Many of the publications did not explicitly report very detailed inclusion and exclusion criteria for the selection of movies. The portrayal of dentists was covered in 5 publications. The symbolic meaning of teeth was covered in 2 publications. (One publication covered both dentist portrayal and teeth symbolism.) Scenes of oral hygiene practice were investigated in 1 publication.
    Conclusion: The portrayal of dentists in movies has often been negative, which may influence public perception and contribute to dental anxiety. Future research should investigate the impact of these portrayals on audience attitudes and behavior, as this review underscores the need for more empirical studies in this area. Meanwhile, readers should notice that one major limitation of this review is the small number of publications included.
    Keywords:  content analysis; dental anxiety; dentistry; movies; portrayal
    DOI:  https://doi.org/10.3389/froh.2025.1584382
  48. Cureus. 2025 Apr;17(4): e81836
      This bibliometric study introduces a novel approach to assessing the application of artificial intelligence (AI) in dentistry. It analyzes trends in AI utilization across dental disciplines, treatment stages, data modalities, subsets, models, and tasks and proposes a comprehensive classification framework for AI applications in dentistry. A systematic search in the Web of Science Core Collection on December 1, 2024, using AI- and dentistry-related keywords identified original and review articles employing true AI. Data on publication details, study types, dental disciplines, treatment stages, AI subsets, models, data modalities, and tasks were extracted and analyzed using VOSviewer (Leiden University, Leiden, Netherlands) and Microsoft Excel (Microsoft Corp., Redmond, WA). Trend analysis and forecasting methods were applied to identify future research directions. Of 2,810 records, 1,368 studies met the inclusion criteria, revealing a continuous rise in AI-related dental research. While most studies focused on diagnostic applications and the orthodontics discipline, the highest recent growth was seen in treatment planning and research and education applications. Hybrid AI models and natural language processing (NLP) experienced significant increases in adoption. The most common AI tasks were classification, detection, and segmentation, although notable growth occurred in generation, data integration, and decision support. The classification framework for AI in dentistry is presented. Text-based data have shown the greatest growth among data modalities, alongside an increased use of sensor and signal data. Future research should prioritize developing NLP and hybrid AI models, conducting original studies in research and education and treatment planning, and undertaking systematic reviews focused on the diagnosis stage of prosthodontics and endodontics.
    Keywords:  artificial intelligence; deep learning; dental treatment; dentistry; machine learning
    DOI:  https://doi.org/10.7759/cureus.81836
  49. Adv Radiat Oncol. 2025 Jun;10(6): 101767
       Purpose: Funding to support radiation oncology discovery and research is essential for advancement in therapeutic strategies to improve outcomes for patients with cancer. We aimed to comprehensively characterize trends in National Institutes of Health (NIH) funding that supports radiation oncology research over time to identify trends, successes, and areas for improvement.
    Methods and Materials: We queried the NIH Research Portfolio Online Reporting Tools Expenditures and Results database to identify all awarded grants to support radiation oncology research conducted by principal investigators at academic centers, using 3 individual years as representative samples (2011, 2016, and 2021). Abstracts and keywords for resulting grants were manually searched to identify resulting awards topically related to the field of radiation oncology; principal investigators departmental affiliation was also used as a supplemental method serving as a sensitivity analysis to define radiation oncology-related research. Descriptive statistics were used to describe patterns in funding. χ2 testing was used to assess differences in proportions of categorical variables.
    Results: Less than 0.5% of the total NIH budget and < 2% of the total National Cancer Institute budget supported radiation oncology research during the representative study years. There were no significant changes in this allocation pattern over time. A small cohort of institutions held a relatively large proportion of NIH-supported radiation oncology grant funding. Individuals holding PhDs alone received the majority of funding (62%), whereas those with dual-degrees (MD/PhD) held 21% of funding, and those with MD alone were awarded 17% of funding. There was a trend toward an increased proportion of grants awarded to MD/PhDs over time (24% vs 15% in 2021 and 2011, respectively, P = .075).
    Conclusions: Despite radiation therapy's essential role in multidisciplinary cancer care, NIH, and National Cancer Institute funding to support radiation oncology research has remained disproportionally low over the last decade. These data may be useful to inform future policy aimed at promoting research advancement in radiation oncology both at the micro (individual) as well as macro (institutional and national) level.
    DOI:  https://doi.org/10.1016/j.adro.2025.101767
  50. IEEE Trans Vis Comput Graph. 2025 May 07. PP
      Dimensionality reduction is used as an important tool for unraveling the complexities of high-dimensional datasets in many fields of science, such as cell biology, chemical informatics, and physics. Visualizations of the dimensionally-reduced data enable scientists to delve into the intrinsic structures of their datasets and align them with established hypotheses. Visualization researchers have thus proposed many dimensionality reduction methods and interactive systems designed to uncover latent structures. At the same time, different scientific domains have formulated guidelines or common workflows for using dimensionality reduction techniques and visualizations for their respective fields. In this work, we present a critical analysis of the usage of dimensionality reduction in scientific domains outside of computer science. First, we conduct a bibliometric analysis of 21,249 academic publications that use dimensionality reduction to observe differences in the frequency of techniques across fields. Next, we conduct a survey of a 71-paper sample from four fields: biology, chemistry, physics, and business. Through this survey, we uncover common workflows, processes, and usage patterns, including the mixed use of confirmatory data analysis to validate a dataset and projection method and exploratory data analysis to then generate more hypotheses. We also find that misinterpretations and inappropriate usage is common, particularly in the visual interpretation of the resulting dimensionally reduced view. Lastly, we compare our observations with recent works in the visualization community in order to match work within our community to potential areas of impact outside our community. By comparing the usage found within scientific fields to the recent research output of the visualization community, we offer both validation of the progress of visualization research into dimensionality reduction and a call for action to produce techniques that meet the needs of scientific users.
    DOI:  https://doi.org/10.1109/TVCG.2025.3567989
  51. Transl Gastroenterol Hepatol. 2025 ;10 29
       Background: Gastroesophageal reflux disease (GERD) presents a complex pathophysiological challenge with intricate interactions among its biological components, yet the mechanisms remain incompletely understood. This study aimed to conduct a quantitative analysis to investigate the concentration and evolution of domain knowledge in GERD research.
    Methods: A bibliographic search in PubMed retrieved 18,459 abstracts of experimental studies on GERD, published between 1963 and 2022. Abstracts were scanned automatically for 477 biological components proposed in recent publications, which are represented by a set of (I) genes and molecules (n=180), (II) definition of cytology, histology, and anatomy (n=54), (III) clinical definition (n=243). For each component, semantic synonyms were recovered from catalogues and domain knowledge. The results are visualized as networks indicating the frequency at which different components are referenced together within each abstract.
    Results: Over time the GERD network has seen a progression in the increasing of new components and connectivity. The clinical definition appears to be the most abundant, while studies exploring micro-level mechanisms remain notably scarce. Meanwhile, certain pivotal components consistently attract significant attention, forming crucial elements in this multifactorial disease. However, the micro-level analysis reveals a recent plateau in progress, indicating a bottleneck phase currently.
    Conclusions: GERD domain knowledge has remained confined within established frameworks over history, highlighting the importance of developing novel integrated research paradigms among endless data to bridge the gap between bench and bedside.
    Keywords:  Network analysis; gastroesophageal reflux disease (GERD); knowledge construction
    DOI:  https://doi.org/10.21037/tgh-24-84
  52. Naunyn Schmiedebergs Arch Pharmacol. 2025 May 03.
      Naunyn-Schmiedeberg's Archives of Pharmacology has been a prominent journal in pharmacology since its inception in 1873, contributing significantly to experimental and clinical pharmacology, as well as toxicology. Despite its origins as the official journal of the German Society of Experimental and Clinical Pharmacology and Toxicology, there is a commonly held assumption that it predominantly publishes research from Germany. This study challenges that notion by examining the journal's publication dynamics over time, including the historical output, international participation, and regional contributions. The analysis of 25,931 documents indexed from 1873 to 2025 reveals a significant increase in global engagement, with contributions from 104 countries. While Germany remained the leading contributor until 2020, a decline in its share of publications is observed, with countries like China, India, and Iran surpassing Germany in recent years. The study demonstrates the journal's growing international influence and its evolution into a globally recognized platform for pharmacological research. In parallel with its increasing international reach, the journal has distinguished itself through an active commitment to academic integrity and ethical publishing. Initiatives such as post-publication image reviews, retractions of fraudulent articles, and mandatory AI disclosure policies reflect its proactive stance against scientific misconduct. Furthermore, its support for gender equity and historical accountability-evident in studies on editorial diversity, and award disparities-underscores its role as a pharmacological journal with a conscience. Together, these findings highlight both the geographic diversification and ethical leadership of a journal shaping pharmacological science on a global scale.
    Keywords:  Germany; Global engagement; Global participation; International contributions; Naunyn–Schmiedeberg’s Archives of Pharmacology; Publication dynamics; Regional distribution
    DOI:  https://doi.org/10.1007/s00210-025-04199-4
  53. J Am Vet Med Assoc. 2025 May 02. 1-7
       Objective: To analyze the time from submission to acceptance (review time), acceptance to first online appearance (process time), and total publication time (sum of review and process times) of research publications in a select group of veterinary journals and compare these with results from 2018.
    Methods: Data were collected from 30 sequential research articles in each journal in a backward temporal manner starting with December 2024. Data from 2024 and 2018 were compared by use of Mann-Whitney U tests for each journal.
    Results: 15 of 23 journals improved their process time; 8 of 23 also slightly improved their review time. Two journals increased their review time: one by 1.5 months and the other by 2.5 months. Thirteen journals improved their total time: 2 by 12 to 24 months. One journal had a total publication time of almost 20 months, whereas most journals had times between 6 and 10 months. Two journals had total publication times < 2 months, despite publishing more articles than the sum of articles published by 22 of 23 other journals.
    Conclusions: Most journals improved process time, with some exceptions. Two journals had total times considerably faster than other journals, raising concerns about the quality of the review process in those journals. Several journals had considerable room for improvement in the dissemination of scientific information.
    Clinical Relevance: Authors can use our data when choosing a journal for their manuscript submissions to expedite the publication process of their research but should be wary of submitting to journals claiming extraordinary publication speeds.
    Keywords:  predatory; publication speed; publication time; research; veterinary journals
    DOI:  https://doi.org/10.2460/javma.25.03.0151