bims-evares Biomed News
on Evaluation of research
Issue of 2025–04–27
eighty-one papers selected by
Thomas Krichel, Open Library Society
  1. Research hotspots and trends of post-stroke depression rehabilitation: a bibliometric analysis from 2003 to 2024.
  2. Two decades of vagus nerve stimulation for stroke: a bibliometric analysis.
  3. Bibliometric and visual analysis of scleral contact lenses: global characteristics and research trends from 1976 to 2023.
  4. Evidence-Based Bibliometric Analysis of Acupuncture in Functional Dyspepsia: Clinical Efficacy and Research Trends.
  5. The 100 most-cited articles in thyroid surgery from 1990 to 2023: a bibliometric analysis.
  6. Frontiers and hotspots of 3D technology in prostatectomy from 1999 to 2024: a bibliometric analysis and visualization.
  7. Bibliometric Analysis and Visualized Study of Research on Mesenchymal Stem Cells in Ischemic Stroke.
  8. A bibliometric analysis of programmed cell death in oral cancer literature: research patterns and emerging trends (2000-2024).
  9. A Systematic Review of Research Hotspots and Global Trends in Primary Ovarian Insufficiency Research.
  10. Global research trends and focus on immunotherapy for endometrial cancer: a comprehensive bibliometric insight and visualization analysis (2012-2024).
  11. Mapping the research landscape of PET/CT in lymphoma: insights from a bibliometric analysis.
  12. A bibliometric analysis of artificial intelligence applied to cervical cancer.
  13. Global Trends in Artificial Intelligence and Sepsis-Related Research: A Bibliometric Analysis.
  14. Global trends in artificial intelligence research in anesthesia from 2000 to 2023: a bibliometric analysis.
  15. Analysis of bibliometric research featured in Naunyn-Schmiedeberg's Archives of Pharmacology.
  16. Bibliometric Analysis of Orbital Surgery Using Web of Science Database.
  17. Research progress and future opportunities of pediatric cow milk protein allergy: a bibliometric overview and evidence mapping.
  18. Global research trends and collaborations in acute kidney injury (AKI) and sepsis: a bibliometric analysis (2004-2024).
  19. Bibliometric analysis of research trends and emerging insights of osteoarthritis and chondrocyte hypertrophy.
  20. Global research trends in inflammaging from 2005 to 2024: a bibliometric analysis.
  21. Exploring the Relationship Between Altmetric Attention Scores and Citations: A Study Based on Articles Published in the Journal of Craniofacial Surgery.
  22. Publication activity trends in the field of social media in rheumatology: a Web of Science-based bibliometric analysis.
  23. Research Trends and Mapping Knowledge for Short Implants in Oral and Maxillofacial Surgery.
  24. Application of Artificial Intelligence in Retinopathy of Prematurity From 2010 to 2023: A Bibliometric Analysis.
  25. Xenotransplantation: A Bibliometric Analysis of Current Trends.
  26. Mapping the landscape of metabolic reprogramming research in lung cancer: a bibliometric and visualized analysis.
  27. Global research trends in biomarkers, therapeutic targets, and drugs for amyotrophic lateral sclerosis: a bibliometric and visualization analysis.
  28. Gut microbiota and gastrointestinal tumors: insights from a bibliometric analysis.
  29. A global bibliometric map of Mendelian randomization in lung cancer research: trends, themes, and emerging risks.
  30. Research status and frontiers in liver cancer immunotherapy: a bibliometric perspective on highly cited literature.
  31. Mapping the Knowledge of Research Trends in Sports Performance Asymmetries from 2015 to 2024: A Bibliometric Study and Analysis of the Most-Cited Papers.
  32. A bibliometric and visual analysis based on immune checkpoint inhibitors for hepatocellular carcinoma: 2014 - 2024.
  33. A bibliometric analysis of disability research in Saudi Arabia: Evolving trends, thematic mapping, and gaps.
  34. Alzheimer's disease and insomnia: a bibliometric study and visualization analysis.
  35. A global overview of the use of cone beam computed tomography in dentistry: a bibliometric review focusing on paediatric patients.
  36. A bibliometric and visual analysis of the research status and hotspots of Pulmonary Aspergillosis based on web of science.
  37. Mapping Knowledge Landscapes and Themes Trends of Breast Cancer Stem Cells: A Comprehensive Data-Mining-Based Study.
  38. Knowledge map of programmed cell death in esophageal cancer: a bibliometric analysis.
  39. Bibliometric Perspectives on Inflammatory and Immunological Research in Pediatric Asthma.
  40. Bibliometric study of BioImpacts using a technological impact approach.
  41. Global trends and interdisciplinary insights in Tai Chi research: a bibliometric analysis (2004-2024).
  42. Respiratory Vaccines in Older Adults: A Bibliometric Analysis and Future Research Agenda.
  43. Exploring 97 Years of Aedes aegypti as the Vector for Dengue, Yellow Fever, Zika, and Chikungunya (Diptera: Culicidae): Scientometric Analysis.
  44. Trends in paediatric anaesthesia research publications and the impact of author sex, country of origin, topic, and external funding.
  45. Mapping the rapid growth of multi-omics in tumor immunotherapy: Bibliometric evidence of technology convergence and paradigm shifts.
  46. Mapping the future: bibliometric insights into ferroptosis and diabetic nephropathy.
  47. Bibliometric analysis and knowledge mapping of diabetes mellitus combined with tuberculosis research: trends from 1995 to 2023.
  48. Bibliometric and Visual Analysis of Alzheimer's Disease and Herpes Simplex Virus Type 1 Infection Between 1990 and 2024.
  49. The top 50 most cited articles on minimally invasive Achilles tendon repair: a bibliometric analysis.
  50. Research Hotspots and Trends in Workplace Violence Among Healthcare Professionals: A Bibliometric and Visualization Analysis Based on Web of Science.
  51. Trends and Collaborative Networks in the Use of Electrospun Nanofibers in Dentistry: A Bibliometric Study.
  52. The rise of artificial intelligence for cognitive behavioral therapy: A bibliometric overview.
  53. Uncovering the Science-Policy Interface: Applying Bibliometric Approaches to the Wildfire Risk Management Domain.
  54. In Reply to the Letter to the Editor Regarding "A Bibliometric Analysis of Sitting Position and Air Embolism in Neurosurgery: Top 100 Most Cited Articles."
  55. Intelligent Care: A Scientometric Analysis of Artificial Intelligence in Precision Medicine.
  56. Peripheral nerve blocks for hip fracture surgeries: a bibliometric and visual analysis.
  57. Biomarkers used in the diagnosis and prognosis of gastric cancer in young patients: a scientometric analysis.
  58. The Association Between Publication Record and Career Path for Facial Plastic and Reconstructive Surgery Fellowship Applicants.
  59. Immediate and longer-term impact of the COVID-19 pandemic on scientific productivity in ecology and evolution.
  60. Letter to Editor-Determinants of journal impact factors in Nutrition and Dietetics.
  61. Ecological risk assessment of emerging contaminants on soil and terrestrial ecosystems (2005-2024): a bibliometric and scientometric review.
  62. Global trends in the management of cancer through obesity reduction: a bibliometric based systematic literature review.
  63. Response to "A Bibliometric Analysis of the Integration of mHealth, Telemedicine, and OpenAI in Aesthetic Plastic Surgery: Advancements, Trends, and Future Directions".
  64. Artificial intelligence in ADHD: a global perspective on research hotspots, trends and clinical applications.
  65. National Institutes of Health Funding and Patent Innovation in Academic Otolaryngology (2014-2024).
  66. Characterizing the Field of Mendelian Randomization Studies for Cardiovascular Disease.
  67. RETRACTION: Visualization of the Relationship Between Macrophage and Wound Healing From the Perspective of Bibliometric Analysis.
  68. Scientometric Analysis of Research on Oral and Gut Microbiota and Periodontitis: Collaborative Networks, Emerging Patterns, Thematic Evolution.
  69. Reply to Letter to the Editor: Determinants of journal impact factors in Nutrition and Dietetics.
  70. Opportunities and challenges with artificial intelligence in allergy and immunology: a bibliometric study.
  71. Patient-Related Metadata Reported in Sequencing Studies of SARS-CoV-2: Protocol for a Scoping Review and Bibliometric Analysis.
  72. Response to the letter: Comment on 'A bibliometric analysis of primary health care publication trends in the Asia-Pacific region from 2011 to 2023'.
  73. Mapping the therapeutic landscape of CRISPR-Cas9 for combating age-related diseases.
  74. The Evolvement of the 100 Most Cited Articles in Spine Surgery In the Last Decade Compared to All-Time.
  75. Gender Parity in CERA Survey Submissions.
  76. Global trends and prospects in research on heavy metal pollution at contaminated sites.
  77. Erratum: Bibliometrics effects of a new paper level classification.
  78. An Evaluation of Current Trends in AI-Generated Text in Otolaryngology Publications.
  79. Exploring the Multifaceted Metabolic Pathology and Mechanisms of NAFLD: A Bibliometric Analysis and an In-depth Review.
  80. Costs of Academic Engagement in Organized Neurosurgery in the United States.
  81. China overtakes the United States in cancer research output.
  1. Front Neurol. 2025 ;16 1526506
    Research hotspots and trends of post-stroke depression rehabilitation: a bibliometric analysis from 2003 to 2024.
    Hongwei Cai, Shini Cai, Aihong Li, Aisong Guo.
       Background: Post-stroke depression (PSD) is a common complication of stroke and is associated with stroke prognosis. Rehabilitation plays an essential role in the comprehensive treatment of PSD. However, there are few bibliometric analyses of studies on PSD rehabilitation. This study aimed to comprehensively sort out the network of PSD rehabilitation through bibliometric analyses, analyze the research trends, focus on the hotspots related to PSD rehabilitation, and provide new research perspectives and guidance for future studies.
    Methods: The Web of Science Core Collection (WoSCC) database was searched for studies about depression rehabilitation after a stroke. The search covered the period from January 1, 2003, to October 31, 2024. We analyzed countries, institutions, journals, authors and keywords using CiteSpace and VOSviewer software to create visualizations and perform a bibliometric analysis.
    Results: A total of 2,227 papers were analyzed, with an increasing trend in the number of papers published each year. The United States had the highest number of published articles (458 publications), and Maastricht University and Utrecht University were the most published institutions (56 articles). Archives of Physical Medicine and Rehabilitation is the journal with the most cited publications (5,913 citations). Johanna M. A. is the most prolific author (24 publications).
    Conclusion: Using bibliometric methods, relevant studies on PSD rehabilitation were reviewed. The hotspots of future research on PSD rehabilitation will center on the brain plasticity mechanism of PSD rehabilitation, PSD assessment, and new techniques of PSD rehabilitation. This article provides systematic information to support and guide future research in this area.
    Keywords:  Citespace; VOSviewer; bibliometric analysis; post-stroke depression; rehabilitation
    DOI:  https://doi.org/10.3389/fneur.2025.1526506
  2. Front Neurol. 2025 ;16 1531127
    Two decades of vagus nerve stimulation for stroke: a bibliometric analysis.
    Jiao Deng, Zhen Yang, Qing Mei Wang, Zhi Gang Lv.
       Background: Stroke is a major global health concern, imposing significant medical and social burdens. Vagus nerve stimulation (VNS), an emerging neuromodulation technology, has shown potential in the treatment of stroke. This bibliometric analysis aims to explore the knowledge structure and research trends in the field of VNS for stroke from 2004 to 2024.
    Methods: Publications were retrieved from the Web of Science Core Collection. CiteSpace and VOSviewer were used to conduct bibliometric analyses, including author productivity, institutional contributions, and emerging research themes etc.
    Results: A total of 191 eligible publications were analysed. Kilgard, M. P., and Hays, S. A. were the most prolific authors, each contributing 26 publications. The USA (96 publications), China (69 publications), and Scotland (17 publications) were the most prolific countries. The University of Texas at Dallas (33 publications) was the most prolific institution, followed by Chongqing Medical University (19 publications) and the University of Glasgow (15 publications). Future research is expected to focus on: (1) neurophysiological mechanisms of VNS in stroke recovery; (2) synergistic effects of VNS with other rehabilitation therapies; (3) comparative efficacy of non-invasive transauricular VNS versus invasive VNS; (4) safety and effectiveness of VNS for post-stroke functional impairments beyond motor rehabilitation; and (5) optimisation of VNS parameters for stroke treatment.
    Conclusion: The field of VNS for stroke has experienced steady growth over the past two decades. This bibliometric analysis provides valuable insights to guide future research, clinical applications, and policy developments.
    Keywords:  VNS; bibliometric analysis; knowledge map; rehabilitation; stroke
    DOI:  https://doi.org/10.3389/fneur.2025.1531127
  3. Int J Ophthalmol. 2025 ;18(4): 735-743
    Bibliometric and visual analysis of scleral contact lenses: global characteristics and research trends from 1976 to 2023.
    Jing Gao, Yao Xu.
       AIM: To gain insight into the future research directions in scleral contact lenses (SCLs) through a comprehensive bibliometrics study.
    METHODS: The publications related to SCLs were screened from the Web of Science Core Collection (WOSCC) database. All bibliographic information was extracted and used to conduct a performance analysis. CiteSpace and VOSviewer were employed to visualize annual publication counts, journals, authors, countries, institutions, collaboration networks, keywords, and references.
    RESULTS: A total of 498 articles were included in our analysis and the number of publications about SCLs showed a significant yearly increase. These publications predominantly emanated from 523 institutions across 38 countries, with the United States and Australia leading in frequency. Totally 1361 authors were identified, among whom Vincent J. Stephen exhibited the highest number of publications, while Jacobs S. Deborah received the most citations. Notably, the journal Contact Lens & Anterior Eye emerged as the primary publisher of studies, and it also boasted the highest citation rate. "Fluid-ventilated, gas-permeable scleral contact lens is an effective option for managing severe ocular surface disease and many corneal disorders that would otherwise require penetrating keratoplasty" was the most cited paper published in eye & contact lens in 2005. The most prevalent keywords encompassed "keratoconus", "scleral contact lenses", "management", "contact lenses", "scleral contact lens", "ocular surface disease", "dry eye", and "contact lens".
    CONCLUSION: Although SCLs have demonstrated significant potential in ophthalmological care, the results offer valuable insights pertinent to future research directions and clinical practice. Greater emphasis should be placed on developing enhancements in design, materials, and fitting technique, as well as on reducing the complications associated with SCLs.
    Keywords:  bibliometric analysis; scleral contact lenses; visual analysis
    DOI:  https://doi.org/10.18240/ijo.2025.04.21
  4. J Multidiscip Healthc. 2025 ;18 2141-2153
    Evidence-Based Bibliometric Analysis of Acupuncture in Functional Dyspepsia: Clinical Efficacy and Research Trends.
    XinJing Wei, XiaoFei Jia, XiaoLan Su.
       Objective: The method of bibliometric analysis was used to visualize the literature data of the current research on acupuncture treatment of functional dyspepsia.
    Methods: By using the bibliometrix package in R4.4.1, all the research literatures related to acupuncture and moxibustion treatment of functional dyspepsia in the WOS core database were used, and the data visualization analysis of the retrieved research literatures was carried out.
    Results: A total of 489 research literatures on acupuncture treatment of functional dyspepsia were screened out. The earliest related research was published in 2009. After 2013, the research heat in this field increased rapidly, reaching its peak in 2022. The number of publications and citations related to acupuncture treatment of functional dyspepsia in China ranked first. Analysis of cumulative publication volume shows that from 2012 to 2024, JEVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDIC ranked first in cumulative publication volume. A total of 1841 authors contributed to this field. The top three authors were WU HG, LIU HR and LI Y. WU HG ranked first in author influence and citation frequency. The most frequently used keyword in the articles published by these authors was "irritable-bowel-syndrome". The high-frequency keywords in the literature on acupuncture treatment of functional dyspepsia were statistically analyzed. The top three high-frequency words were irritable-bowel-syndrome, followed by acupuncture and electroacupuncture.
    Conclusion: Acupuncture treatment of functional dyspepsia related research was first published in 2009, the research heat increased year by year. The most authoritative author in the field of acupuncture treatment of functional dyspepsia is WU HG.
    Keywords:  acupuncture; bibliometric; functional dyspepsia
    DOI:  https://doi.org/10.2147/JMDH.S515144
  5. Gland Surg. 2025 Mar 31. 14(3): 498-509
    The 100 most-cited articles in thyroid surgery from 1990 to 2023: a bibliometric analysis.
    Donglun Li, Yue Hu, Yingjun Zheng, Lin Chun, Jiayi Song, Caihong Cao, Jianxiong Wang.
       Background: The 2015 U.S. guidelines for the diagnosis and treatment of thyroid nodules are recognized as authoritative in the industry, but lack a comprehensive assessment of the development of this field. The purpose of this bibliometric analysis is to identify and assess the 100 most-cited articles that have shaped the modern history of thyroid surgery.
    Methods: The Web of Science Core Collection database was used to search the 100 most-cited articles in the field of thyroid surgery. VOSviewer was used to visually analyse countries/regions, institutions, authors, keywords, and characteristics of the top-100 articles.
    Results: The citations of the 100 most-cited articles published between January 1990 and January 2023 ranged from 279 to 7,073. The 100 most-cited articles were published by 25 countries, over half of which were from the USA (n=54). Harvard University (14 articles) and University System of Ohio (14 articles) from the USA (The United States of America) were the top institutions. Schlumberger M from the Institute Gustave Roussy and University Paris Sud was the most productive author with 10 articles. The top-cited article was published by Haugen Bryan R et al. in Thyroid [2015] (citations =7,073). The keywords with the most co-occurrences were carcinoma, followed by fine-needle-aspiration, management, follow up, biopsy, radioactive iodine, and braf (v600e) mutation.
    Conclusions: The top 100 articles in thyroid surgery have been cited widely and have had a profound impact. The USA was the most influential and productive country. Harvard University and University System of Ohio contributed most to the top 100 articles. Schlumberger M was the most productive and influential author. Moreover, especially thyroid papillary carcinoma, fine needle aspiration, is a research hotspot and potential direction in the future for thyroid surgery.
    Keywords:  Thyroid surgery; VOSviewer; bibliometric analysis; citation; thyroid cancer
    DOI:  https://doi.org/10.21037/gs-2024-559
  6. Gland Surg. 2025 Mar 31. 14(3): 436-450
    Frontiers and hotspots of 3D technology in prostatectomy from 1999 to 2024: a bibliometric analysis and visualization.
    Jingke He, Chengcheng Wei, Shuai Su, Yu Luo, Yunfan Li, Kun Han, Lincen Jiang, Jindong Zhang, Delin Wang.
       Background: Prostate cancer is a major global health issue. Radical prostatectomy is an effective treatment for prostate cancer. The integration of three-dimensional (3D) technology in prostatectomy offers numerous benefits. We intended to perform a bibliometric analysis of the role of 3D technology in prostatectomy.
    Methods: Articles and review articles related to "3D" and "prostatectomy" were retrieved from Web of Science Core Collection. Microsoft Office Excel, CiteSpace, and VOSviewer were utilized for analysis and visualization.
    Results: A total of 441 articles were collected. The annual publication volume and journal distribution were illustrated. Visualizations of collaborations among countries/regions, institutions, and authors were provided. Networks of reference co-citations and keyword co-occurrences, along with their respective clusters were plotted.
    Conclusions: The number of published papers significantly increased over the last 25 years. The most productive and influential country was the USA, and The University of California System was the most influential institution. The journal with the highest number of publications was BJU International. Among all authors in this field, Wijkstra H has published the most papers. Porpiglia F was the most cited author. Previous hot topics included advanced imaging and clinical trials, whereas augmented reality (AR) and robotics are likely to be hot topics in the future.
    Keywords:  Bibliometric; hotspots; prostate cancer; prostatectomy; robot-assisted surgery
    DOI:  https://doi.org/10.21037/gs-2024-483
  7. Stem Cell Rev Rep. 2025 Apr 21.
    Bibliometric Analysis and Visualized Study of Research on Mesenchymal Stem Cells in Ischemic Stroke.
    Fanwei Bu, Xinmei Yuan, Xiaocan Cui, Ruyue Guo.
       BACKGROUND: One of the major global causes of death and disability is ischemic stroke (IS). Mesenchymal stem cells (MSCs) emerge as a cell-based therapy for numerous diseases. Recently, research on the role of MSCs in ischemic stroke has developed rapidly worldwide. Bibliometric analysis of MSCs for IS has not yet been published, though.
    AIM: Through bibliometric analysis, the aim of this study was to assess the current state of research on MSCs in the field of ischemic stroke research worldwide and to identify important results, major research areas, and emerging trends.
    METHODS: Publications related to MSCs in ischemic stroke from January 1, 2002, to December 31, 2022, were obtained from the Web of Science Core Collection (WoSCC). We used HistCite, VOSViewer, CiteSpace, and Bibliometrix for bibliometric analysis and visualization. We employed the Total Global Citation Score (TGCS) to assess the impact of publications.
    RESULTS: The bibliometric analysis included a total of 2,048 publications. The 1,386 papers used in this study were authored by 200 individuals across 200 organizations in 72 countries, published in 202 journals. Cesar V Borlongan published the most documents among high-productivity authors. Michael Chopp was the author with the highest average number of citations per paper, with an average paper citation time of 118.54. We found that research of MSCs in ischemic stroke developed rapidly starting in 2008. Neurosciences were the most productive journals, and Chinese researchers have produced the most research papers in this subject. The most cited article is "Systemic administration of exosomes released from mesenchymal stromal cells promotes functional recovery and neurovascular plasticity after stroke in rats".
    CONCLUSION: This study uses both numbers and descriptions to thoroughly review the research on MSCs related to IS. This information provides valuable experience for researchers to carry out MSCs' work on IS.
    Keywords:  Bibliometric analysis; Ischemic stroke; Mesenchymal stem cells
    DOI:  https://doi.org/10.1007/s12015-025-10878-9
  8. Discov Oncol. 2025 Apr 22. 16(1): 585
    A bibliometric analysis of programmed cell death in oral cancer literature: research patterns and emerging trends (2000-2024).
    Wenli Gu.
       BACKGROUND: Programmed cell death (PCD) plays a crucial role in oral cancer pathogenesis and treatment. However, a comprehensive bibliometric analysis of the global research landscape in this field has not been conducted. This study aims to analyze the evolution and current trends of PCD research in oral cancer from 2000 to 2024.
    METHODS: Publications were retrieved from the Web of Science Core Collection database using relevant keywords related to oral cancer and PCD. VOSviewer 1.6.20 and CiteSpace 6.1R6 software were employed to conduct bibliometric analysis, including publication trends, citation analysis, co-authorship networks, keyword co-occurrence, and research hotspots. The time span was set from January 2000 to December 2024.
    RESULTS: A total of 963 publications were identified and analyzed. The annual publication output showed a steady increase, with a significant growth rate after 2010, dividing the study period into three distinct phases. The most productive countries were China (58.42%), South Korea (12.27%), and Japan (10.04%), with China Medical University and Kaohsiung Medical University being the leading institutions. Research hotspots evolved from traditional apoptosis studies to emerging forms of PCD such as autophagy, ferroptosis, and pyroptosis. Keyword analysis revealed three major research clusters: basic molecular mechanisms (centered around ROS and oxidative stress), clinical aspects (including prognosis and cell proliferation), and cell death pathways. Citation burst analysis identified emerging trends in targeting multiple PCD pathways simultaneously for oral cancer therapy, with special focus on treatment resistance and survival.
    CONCLUSION: This bibliometric analysis provides a comprehensive overview of global research trends in PCD and oral cancer over the past two decades. The findings highlight the shift from basic mechanistic studies focusing on apoptosis to more diverse PCD pathways and translational research. Emerging research directions include the exploration of synergistic mechanisms among multiple PCD pathways, development of AI-based personalized treatment plans, investigation of microenvironment regulation of PCD, and application of novel drug delivery systems. These trends demonstrate the field's evolution toward more integrated, personalized approaches in oral cancer treatment. This study offers valuable insights for researchers and funding agencies to identify research gaps and potential collaboration opportunities in this rapidly developing field.
    Keywords:  Apoptosis; Autophagy; Bibliometric analysis; Oral cancer; Programmed cell death; Research trends
    DOI:  https://doi.org/10.1007/s12672-025-02410-9
  9. Endocr Metab Immune Disord Drug Targets. 2025 Apr 21.
    A Systematic Review of Research Hotspots and Global Trends in Primary Ovarian Insufficiency Research.
    Yiwen Zhang, Siyuan Lei, Meixiang Li, Xiaocan Lei, Xuan Liu, Weihua Nong, Jiaming Zhang.
       BACKGROUND: The aim of this study was to perform a bibliometric analysis of primary ovarian insufficiency (POI) from 2013 to 2022, to observe global research trends and hotspots in the last ten years, and to provide direction for further research and development of POI in the future.
    METHOD: 4840 articles and reviews related to POI, published from January 1st, 2013 to December 31st, 2022, were retrieved from the Web of Science Core Collection for bibliometric analysis. CiteSpace and VOSviewer were used to analyze countries and regions, organizations, authors, journals, and keywords.
    RESULTS: The literature on POI shows an upward trend year by year. In the last ten years, China, the United States, and English have published the largest number of publications in this field with the greatest influence. According to the keyword analysis, the main research hotspots of POI revolve around mesenchymal stem cells.
    CONCLUSION: This study is possibly the first bibliometric analysis that focuses on multiple indicators to analyze the published literature on POI in recent years, hoping to provide some ideas for subsequent authors working in this field and provide new perspectives on research trends and possible hotspots in POI.
    Keywords:  POI; Primary ovarian insufficiency; bibliometric analysis; citespace; research hotspots; trends.; visualization analysis
    DOI:  https://doi.org/10.2174/0118715303339221250319041923
  10. Front Immunol. 2025 ;16 1571800
    Global research trends and focus on immunotherapy for endometrial cancer: a comprehensive bibliometric insight and visualization analysis (2012-2024).
    Yachen Xu, Tao Wang, Xiaojing Liang, Jie Yang, Yuxiang Zhang, Shan Bao.
       Background: This study conducted a novel systematic bibliometric and visualization analysis of global literature on immunotherapy for endometrial cancer (EC) to explore dynamic trends, research hotspots, and emerging topics, providing valuable references for future research.
    Methods: Articles and reviews on EC immunotherapy published between 2012 and August 2024 were retrieved from the Web of Science Core Collection (WoSCC). Bibliometric tools, CiteSpace and VOSviewer, were used to analyze clustering patterns and research dynamics.
    Results: A total of 861 articles were contributed by 5,331 authors from 1,392 institutions across 58 countries or regions, involving 1,823 keywords. China demonstrated outstanding performance in this field, contributing over 40% of the total publications and ranking first in publication volume. However, the total citation counts for publications from China lags that of the United States, highlighting the latter's leading position and areas for further improvement in China's research efforts. The University of Texas Medical Anderson Cancer Center and Nanjing Medical University were the two institutions with the highest number of publications. In terms of authorship, research teams led by Bosse, Tjalling, and Creutzberg, Carien L made significant contributions to advancing the field. Among individual publications, the work by Talhouk et al. achieved the highest average annual citation count of 70.88, demonstrating its profound impact. In terms of journals, Gynecologic Oncology emerged as a pivotal academic platform, publishing numerous articles and achieving the highest co-citation frequency. Additionally, Frontiers in Oncology, Frontiers in Immunology, and Frontiers in Genetics have become some of the most active and rapidly developing journals in recent years. Research hotspots are concentrated on themes such as the "Tumor Immune Microenvironment", "Immune Checkpoint Inhibitors", and "Targeted Therapy". Recent trends and frontier research focus on the combined application of immune checkpoint inhibitors with other therapies, research on the application of nanotechnology in immunotherapy, and the integration of artificial intelligence to enhance precision medicine. Additionally, efforts are increasingly directed toward advancing various immunotherapy strategies from basic research to clinical applications.
    Conclusions: This comprehensive analysis reveals rapid advancements and significant potential in EC immunotherapy. Strengthening international collaboration and addressing barriers in the translation of research to clinical practice will drive further progress in this promising field.
    Keywords:  bibliometric analysis; emerging topics; endometrial cancer; immunotherapy; research hotspots
    DOI:  https://doi.org/10.3389/fimmu.2025.1571800
  11. Front Oncol. 2025 ;15 1513296
    Mapping the research landscape of PET/CT in lymphoma: insights from a bibliometric analysis.
    Die Zhang, Jianding Peng, Yingjie Zhu, Qiang Gong, Qing Wang, Chaodong Xiang, Hanjian Du, Xiaofei Hu.
       Objective: This study provides a comprehensive bibliometric analysis of research trends in Positron Emission Tomography/Computed Tomography (PET/CT) applications for lymphoma, aiming to identify key contributors, emerging topics, and collaboration patterns within the field.
    Methods: Data from the Web of Science Core Collection (2004-2024) were analyzed. Original articles and reviews in English on PET/CT in lymphoma staging, response assessment, or prognosis were included, while case reports, meeting abstracts, and editorials were excluded. Using CiteSpace, VOSviewer, and Bibliometrix R, we evaluated country/institutional contributions, co-citation networks, keyword trends, and employed linear regression for trend forecasting.
    Results: A total of 2,962 papers related to PET/CT and lymphoma were published during the study period. The annual publication volume increased significantly, peaking in 2021 with 281 papers, followed by a decline to 260 in 2023, potentially linked to COVID-19-related research disruptions. The United States and China led in publication volume, contributing over 40% of global publications. Leading institutions included UNICANCER and Assistance Publique Hôpitaux de Paris. Influential authors such as Sally F. Barrington and Michel Meignan were identified. The European Journal of Nuclear Medicine and Molecular Imaging and the Journal of Nuclear Medicine were the top journals in this field. Key research themes included staging, response assessment, prognosis, and the role of PET/CT in personalized treatment approaches.
    Conclusion: This bibliometric analysis highlights the significant growth and evolving trends in PET/CT research for lymphoma. The findings underscore the critical role of PET/CT in advancing precision medicine, informing future research directions, and optimizing clinical practices in lymphoma management.
    Keywords:  PET/CT; bibliometric analysis; diagnostic imaging; lymphoma; precision medicine
    DOI:  https://doi.org/10.3389/fonc.2025.1513296
  12. Front Med (Lausanne). 2025 ;12 1562818
    A bibliometric analysis of artificial intelligence applied to cervical cancer.
    Qiang Huang, Wenmei Su, Shujun Li, Yanming Lin, Zhen Cheng, Yuting Chen, Yanli Mo.
       Objective: This study conducts a bibliometric analysis of artificial intelligence (AI) applications in cervical cancer to provide a comprehensive overview of the research landscape and current advancements.
    Methods: Relevant publications on cervical cancer and AI were retrieved from the Web of Science Core Collection. Bibliometric analysis was performed using CiteSpace and VOSviewer to assess publication trends, authorship, country and institutional contributions, journal sources, and keyword co-occurrence patterns.
    Results: From 1996 to 2024, our analysis of 770 publications on cervical cancer and AI showed a surge in research, with 86% published in the last 5 years. China (315 pubs, 32%) and the US (155 pubs, 16%) were the top contributors. Key institutions were the Chinese Academy of Sciences, Southern Medical University, and Huazhong University of Science and Technology. Research hotspots included disease prediction, image analysis, and machine learning in cervical cancer. Schiffman led in publications (12) and citations (207). China had the highest citations (3,819). Top journals were "Diagnostics," "Scientific Reports," and "Frontiers in Oncology." Keywords like "machine learning" and "deep learning" indicated current research trends. This study maps the field's growth, highlighting key contributors and topics.
    Conclusion: This bibliometric analysis provides valuable insights into research trends and hotspots, guiding future studies and fostering collaboration to enhance AI applications in cervical cancer.
    Keywords:  AI; artificial intelligence; bibliometric analysis; cervical cancer; machine learning
    DOI:  https://doi.org/10.3389/fmed.2025.1562818
  13. Shock. 2025 Apr 22.
    Global Trends in Artificial Intelligence and Sepsis-Related Research: A Bibliometric Analysis.
    Xuanjie Hu, Xingli Gu, Huling Li, Honglin Wang, Dandan Tang.
       BACKGROUND: In the field of bibliometrics, although some studies have conducted literature reviews and analyses on sepsis, these studies mainly focus on specific areas or technologies, such as the relationship between the gut microbiome and sepsis, or immunomodulatory treatments for sepsis. However, there are still few studies that provide comprehensive bibliometric analyses of global scientific publications related to AI in sepsis research.
    OBJECTIVE: The aim of this study is to assess the global trend analysis of AI applications in sepsis based on publication output, citations, co-authorship between countries, and co-occurrence of author keywords.
    METHODS: A total of 4,382 papers published from 2015 to December 2024 were retrieved and downloaded from the SCIE database in WOS. After selecting the document types as articles and reviews, and conducting eligibility checks on titles and abstracts, the final bibliometric analysis using VOSviewer and CiteSpace included 4,209 papers.
    RESULTS: The number of published papers increased sharply starting in 2021, accounting for 58.14% (2,447/4,209) of all included papers. The United States and China together account for approximately 60.16% (2,532/4,209) of the total publications. Among the top 10 institutions in AI research on sepsis, seven are located in the United States. Rishikesan Kamaleswaran is the most contributing author, with PLOS ONE having more citations in this field than other journals. SCIENTIFIC REPORTS is also the most influential journal (NP = 106, H-index = 23, IF: 3.8).
    CONCLUSION: This study highlights the popular areas of AI research, provides a comprehensive overview of the research trends of AI in sepsis, and offers potential collaboration and future research prospects. To make AI-based clinical research sufficiently persuasive in sepsis practice, collaborative research is needed to improve the maturity and robustness of AI-driven models.
    Keywords:  Artificial Intelligence; Bibliometric Analysis; Deep Learning; Machine Learning; Sepsis
    DOI:  https://doi.org/10.1097/SHK.0000000000002598
  14. Perioper Med (Lond). 2025 Apr 23. 14(1): 47
    Global trends in artificial intelligence research in anesthesia from 2000 to 2023: a bibliometric analysis.
    Yi Ou, Xiaoyi Hu, Cong Luo, Yajun Li.
       BACKGROUND: Interest in artificial intelligence (AI) research in anesthesia is growing rapidly. However, there is a lack of bibliometric analysis to measure and analyze global scientific publications in this field. The aim of this study was to identify the hotspots and trends in AI research in anesthesia through bibliometric analysis.
    METHODS: English articles and reviews published from 2000 to 2023 were retrieved from the Web of Science Core Collection (WoSCC) database. The extracted data were summarized and analyzed using Microsoft Excel, and bibliometric analysis were conducted with VOSviewer software.
    RESULTS: AI research literature in anesthesia has exhibited rapid growth in recent years. The United States leads in the number of publications and citations, with Stanford University as the most prolific institution. Hyung-Chul Lee is the author with the highest number of publications. The journal Anesthesiology is highly recognized and authoritative in this field. Recent keywords include "musculoskeletal pain", "precision medicine", "stratification", "images", "mean arterial pressure", " enhanced recovery after surgery", "frailty", "telehealth", "postoperative delirium" and "postoperative mortality" indicating hot topics in AI research in anesthesia.
    CONCLUSIONS: Publications on AI research in the field of anesthesia have experienced rapid growth over the past two decades and are likely to continue increasing. Research areas such as depth of anesthesia (DOA) and drug infusion (including electroencephalography and deep learning), perioperative risk assessment and prediction (covering mean arterial pressure, frailty, postoperative delirium, and mortality), image classification and recognition (for applications such as ultrasound-guided nerve blocks, vascular access, and difficult airway assessment), and perioperative pain management (particularly musculoskeletal pain) have garnered significant attention. Additionally, topics such as precision medicine, enhanced recovery after surgery, and telehealth are emerging as new hotspots and future directions in this field.
    Keywords:  Anesthesia; Artificial intelligence; Bibliometrics; VOSviewer
    DOI:  https://doi.org/10.1186/s13741-025-00531-x
  15. Naunyn Schmiedebergs Arch Pharmacol. 2025 Apr 24.
    Analysis of bibliometric research featured in Naunyn-Schmiedeberg's Archives of Pharmacology.
    Siddig Ibrahim Abdelwahab, Abdullah Farasani, Jobran M Moshi, Saeed Alshahrani, Waseem Hassan.
      This study examines twelve (12) bibliometric research published in Naunyn-Schmiedeberg's Archives of Pharmacology and offers suggestions to improve future bibliometric analyses. By reviewing twelve influential studies, the research focuses on identifying trends in methodologies, databases, and bibliometric indicators. The reviewed studies span diverse topics, from the pharmacological effects of emodin to cancer therapies and neurodegenerative diseases. Common techniques, such as keyword co-occurrence analysis, citation burst detection, and country and institutional collaboration networks, were applied to explore research dynamics and emerging trends. However, a key observation is the predominant reliance on the Web of Science Core Collection as the sole database. While this database is widely recognized, the study suggests incorporating multiple databases to reduce bias and provide a more comprehensive understanding of the research landscape. Additionally, it recommends the use of various author performance indicators, such as the H-index, G-index, and M-index, to better capture an author's scholarly impact. The review also emphasizes the value of co-word analysis and citation burst detection in identifying research hotspots and thematic shifts. However, it advocates for more detailed co-word analysis by separately considering titles, abstracts, and keywords, co-words dynamics, and multi-gram analysis. This multi-layered approach could enhance the understanding of evolving research topics. The feedback provided is intended as constructive suggestions aimed at refining methodologies and fostering innovation in bibliometric studies within the field of pharmacology. In the same vein, the immense work of all authors is sincerely appreciated.
    Keywords:  12 papers analysis; Bibliometrics; Citation burst detection; Co-word analysis; Database diversity; Future suggestions; Research trends
    DOI:  https://doi.org/10.1007/s00210-025-04190-z
  16. J Craniofac Surg. 2025 Apr 24.
    Bibliometric Analysis of Orbital Surgery Using Web of Science Database.
    Sema Polat, Ufuk Can Aksay, Mahmut Tunç, Esin Özşahin, Kemal Yar, Pinar Göker.
       AIM: There are more than 100 different clinical pathologies that affect the orbit, originating from the orbit or surrounding structures. Various surgical approaches have been described to solve this number of lesions. To date, there have been few evaluations of research productivity in the field of orbital surgery. The aim of this study is to analyze the research productivity of articles on orbital surgery.
    METHODS: On October 20, 2024, using the advanced search section in the Web of Science (WoS) Core Collection database, a search was made about orbital surgery. From 1980 to November 20, 2024, research articles in the relevant field were analyzed. Language restrictions are not used. The filter was "Topic=Orbital Surgery OR Orbit Surgery OR Oculoplastic OR Oculoplastics OR Oculoplasty OR Orbitotomy OR Orbital Tumor Surgery OR Optic Nerve Surgery OR Orbital Decompression OR Orbital Reconstruction OR Orbital Exenteration OR Orbital Implant Surgery (Should - Search within topic)." Filters were applied, and as a result, 4590 publications were included in this study. VOSviewer software was used to perform bibliometric analyses.
    RESULTS: The number of publications and citations for each year mostly increases until 2021. Among the countries with the most documents and citations, the United States ranks first in both rankings. Also, the organization with the most publications is the University of California, Los Angeles. Ophthalmic Plastic and Reconstructive Surgery is the journal that publishes the most documents and receives the most citations. The most cited 3 document is about Graves orbitopathy. The most recurring keywords were related to treatment and disease management.
    CONCLUSIONS: This study would provide a novel perspective to the studies about orbital surgery and contribute to the researchers about the limits of the topic, and being aware of the active journals that publish the papers on this issue would facilitate the work of the researchers.
    Keywords:  Bibliometric analysis; oculoplastic; orbit; orbital surgery
    DOI:  https://doi.org/10.1097/SCS.0000000000011428
  17. Int Arch Allergy Immunol. 2025 Apr 24. 1-22
    Research progress and future opportunities of pediatric cow milk protein allergy: a bibliometric overview and evidence mapping.
    Li Zhou, Tengfei Li, Qingyong Zheng, Jianguo Xu, Caihua Xu, Bowa Zhang, Zewei Wang, Jie Wang.
       INTRODUCTION: This study employs bibliometric methods to reveal research trends, hot topics, and development trajectories in the field of cow milk protein allergy (CMPA) in children.
    METHODS: We retrieved and downloaded literature on CMPA in children from the Web of Science Core Collection database on the basis of specific search strategies and screening criteria. Using VOSviewer software, we analyzed the collaboration networks among countries, institutions, and authors, as well as the co-occurrence of keywords. We utilized Biblioshiny software to analyze highly cited papers and research trend topics and to construct thematic maps.
    RESULTS: We included 1,128 articles related to pediatric CMPA for analysis. The results show that since 2014, the number of research papers on CMPA has increased. The United States, Italy, and China are the countries with the greatest number of publications, with the United States occupying a central position in the collaboration network. The Icahn School of Medicine at Mount Sinai ranks first in terms of research output. Professor Hugh A. Sampson is the most influential author in this field. The main research areas include clinical manifestations, molecular mechanisms, immune regulation, and immunotherapy for CMPA. Emerging research hotspots in recent years include the gut microbiome, the development of dairy substitutes, and the application of sandwich enzyme-linked immunosorbent assay (sELISA) technology in milk protein detection.
    CONCLUSION: Through bibliometric analysis, this study revealed the research trends and hotspots in the field of CMPA in children. Future research should further strengthen international cooperation to promote in-depth research and effective management of CMPA.
    DOI:  https://doi.org/10.1159/000545367
  18. Ren Fail. 2025 Dec;47(1): 2494049
    Global research trends and collaborations in acute kidney injury (AKI) and sepsis: a bibliometric analysis (2004-2024).
    Yuru Yang, Shuang Zhao, Shuai Liu.
       BACKGROUND: Acute kidney injury (AKI) and sepsis are critical clinical conditions associated with high morbidity and mortality. Despite growing research interest, there remains a need for a comprehensive analysis of global research trends in this field. Bibliometric analysis offers a quantitative approach to assessing the evolution of scientific knowledge, collaborative networks, and emerging research areas over time.
    OBJECTIVE: This study aims to map the global landscape of research on AKI and sepsis over the last two decades (2004-2024), identify major contributors, collaboration networks, key research trends, and highlight gaps in the literature.
    METHODS: We conducted a bibliometric analysis of research articles from leading databases. The study utilized network visualization techniques to assess co-authorship, citation patterns, and keyword co-occurrence, focusing on the most influential countries, institutions, and research collaborations.
    RESULTS: Results reveal China leads in publication volume, yet countries like the United States and Australia show higher international collaboration rates and citation impact. Additionally, thematic analyses highlight critical research areas, including biomarkers, bioenergetics, inflammation, and machine learning, marking significant advancements in the understanding and management of AKI.
    CONCLUSION: This bibliometric analysis offers valuable insights into the evolving landscape of AKI and sepsis research, emphasizing the importance of collaborative efforts to address knowledge gaps and ensure evidence-based care across diverse healthcare settings. Future research should prioritize the development of biomarkers and the integration of AI-driven technologies to enhance early diagnosis and personalize treatment strategies for AKI patients.
    Keywords:  Acute kidney injury (AKI); acute kidney failure (ARF); bibliometric analysis; sepsis
    DOI:  https://doi.org/10.1080/0886022X.2025.2494049
  19. Front Surg. 2025 ;12 1538339
    Bibliometric analysis of research trends and emerging insights of osteoarthritis and chondrocyte hypertrophy.
    Jiajin Fang, Shuai Wang.
       Background: This study aims to systematically analyze the intersection of OA and chondrocyte hypertrophy using bibliometric methods, providing an quantitative and comprehensive overview of the current research status and emerging trends in this field.
    Methods: Relevant publications were retrieved from the Web of Science Core Collection database using the search query TS = ("chondrocyte* hypertroph*" OR "hypertrophic chondrocyte*" OR "cartilage hypertroph*") AND ("osteoarthriti*" OR "OA" OR "degenerative arthritis"). Several bibliometric tools, including Vosviewer, CiteSpace, the R package (bibliometrix), and Excel 2021, were utilized to systematically analyze the publications on the intersection of chondrocyte hypertrophy and OA.
    Results: A total of 639 publications, published between 1995 and 2025, were identified. The findings indicate a steady global increase in research on OA and chondrocyte hypertrophy, with an increasing number of studies being published in high-impact journals, suggesting a promising developmental trajectory. China and the United States are leading in this field. OSTEOARTHRITIS AND CARTILAGE is identified as the core journal in this area, while ANNALS OF THE RHEUMATIC DISEASES has the highest impact factor among the top publishing journals. Keyword analysis reveals that research hotspots primarily focus on stem cells, tissue engineering, cartilage repair, inflammation, oxidative stress, autophagy, apoptosis, senescence, and related bioactive factors.
    Conclusion: This study elucidates the current research status and trends at the intersection of OA and chondrocyte hypertrophy, providing crucial references for future research. Future studies should continue to focus on these potential therapeutic approaches, key phenotypes, and regulatory mechanisms, enhance international cooperation to develop more effective strategies and treatments for OA.
    Keywords:  WoSCC; bibliometric; chondrocyte hypertrophy; hotspots; osteoarthritis
    DOI:  https://doi.org/10.3389/fsurg.2025.1538339
  20. Front Aging. 2025 ;6 1554186
    Global research trends in inflammaging from 2005 to 2024: a bibliometric analysis.
    Beier Jiang, Yi-Ni Dong, Yu Xiong, Chun-Xia Jiang, Jun Ping, Qi Wu, Liu-Jun Xu, Run-Zhe Shu, Dan-Dan Gao, Sheng-Mei Zhu, Wei-Dong Ye, Feng Zhang.
       Background: Inflammaging, defined as chronic low-grade inflammation associated with aging, is considered a key factor in many age-related diseases. Despite growing research, comprehensive assessments of trends and focuses on this field over the past 2 decades remain lacking.
    Objective: To comprehensively analyze literature development trends, scientific priorities, and their evolution in the field of inflammaging from 2005 to 2024 using bibliometric analysis.
    Methods: Academic literature on inflammaging was retrieved from the Web of Science Core Collection. CiteSpace software was used as the bibliometric tool to analyze annual publication trends, contributing countries/regions, leading research institutions, primary journals, and keyword co-occurrence, including clustering and burst analysis in this field.
    Results: The study included 1,800 eligible articles, demonstrating a consistent growth in research publications over the past 20 years. The United States and Italy were the principal contributors. The University of Bologna had the highest publication. Professor Claudio Franceschi has been a leading figure in this field. Journal analysis shows that research themes predominantly focus on molecular biology/immunology and medicine/clinical fields. Keyword analysis identifies major research hotspots as "inflammaging," "Crohn's disease," "periodontitis," "immunosenescence," "skeletal muscle," "gut microbiota," and "Parkinson's disease." Emerging term analysis indicates a shift from specific inflammatory diseases to broader aging and immune modulation studies.
    Conclusion: This first systematic assessment of literature trends in the field of inflammaging from 2005 to 2024 reveals sustained academic growth and an increasingly deep research focus.
    Keywords:  bibliometrics; immunosenescence; inflammaging; research hotspots; scientific trends
    DOI:  https://doi.org/10.3389/fragi.2025.1554186
  21. J Craniofac Surg. 2025 Apr 25.
    Exploring the Relationship Between Altmetric Attention Scores and Citations: A Study Based on Articles Published in the Journal of Craniofacial Surgery.
    Burak Erkmen, Yusuf Muhammed Durna, Şamil Şahin, Yaşar Kemal Duymaz, İlhan Bahşi.
       OBJECTIVE: This study investigates the relationship between Altmetric Attention Scores (AAS) and traditional citation metrics for articles published in the Journal of Craniofacial Surgery between 1990 and 2025. Bibliometric analyses are commonly used to assess the impact and productivity of scientific studies. However, the growing role of social media platforms in academic dissemination has led to the emergence of alternative metrics like AAS, which measure online engagement and attention.
    METHODS: A search conducted on the Dimensions website identified 17,232 articles published during the study period. Of these, 228 articles had an AAS of 5 or higher. The highest AAS values were predominantly associated with articles published in the last decade. Metrics such as the Field Citation Ratio (FCR) and Relative Citation Ratio (RCR) were analyzed alongside AAS values. The top 10 articles with the highest AAS showed that there was no statistical correlation between AAS and traditional citation metrics, including citation count, FCR, and RCR.
    RESULTS: The findings indicate that although altmetric analyses provide valuable insights into the online visibility of articles, they should be used in conjunction with traditional bibliometric methods for a comprehensive evaluation of scholarly impact. The study also underscores the need for further research to understand the interplay between social media engagement and academic citations.
    CONCLUSIONS: This research contributes to the ongoing discourse on the utility of altmetrics in complementing traditional metrics and provides insights for evaluating the multifaceted impact of scientific publications.
    Keywords:  Altmetric analyses; altmetric attention scores; altmetrics; bibliometrics; citations; research impact; social media
    DOI:  https://doi.org/10.1097/SCS.0000000000011420
  22. Rheumatol Int. 2025 Apr 25. 45(5): 119
    Publication activity trends in the field of social media in rheumatology: a Web of Science-based bibliometric analysis.
    Maidan Mukhamediyarov, Dana Bekaryssova.
      Social media (SoMe) is crucial in disseminating information and raising awareness about health conditions. In recent years, rheumatology specialists have increasingly utilized social networks to support and promote scientific research. This study presents a bibliometric analysis of global social media and rheumatology trends, identifying leading authors, citation patterns, and emerging research areas. The analysis used data exported from Web of Science (WoS) from 2015 to 2024. The search used MeSH-derived keywords, specifically "social media rheumatology," without applying filters, covering January 2015 to December 2024 timeframe. A comprehensive search resulted in retrieving 251 publications. After ranking these publications and applying inclusion and exclusion criteria, 152 articles were included in the final analysis. A total of 152 publications were analyzed, revealing a significant positive trend in the number of publications over time (p = 0.001). The leading countries in terms of publication activity were the US (35.53%), the United Kingdom (32.24%), Australia (11.18%), Germany (9.87%), and France (9.21%). The research originated from 66 countries, but only 18 demonstrated substantial activity. The US led in scientific contributions relative to population and Gross Domestic Product (GDP). Regarding publication types, 137 (90.13%) were original research articles, while the remainder were review articles. The median citation count for original articles was 5 (range: 0-116), while review articles had a higher median citation count of 28 (range: 0-156), indicating that reviews were cited more frequently than original studies (p = 0.001). The median citation count for publications indexed in SCIE, SSCI, and ESCI was 5.5 (range: 0-116) and 6 (range: 0-116), respectively. Most publications were published in the following journals: Clinical Rheumatology (n = 25), Rheumatology Advances in Practice (n = 25), Rheumatology International (n = 16), BMJ Open (n = 12) and Journal of Medical Internet Research (n = 8). High-income countries, such as the US, the United Kingdom, and Australia, have significantly contributed to the field of social medicine in rheumatology, underscoring disparities in scientific research capacity across different regions.
    Keywords:  Bibliometric analysis; Bibliometrics; Rheumatology; Social media
    DOI:  https://doi.org/10.1007/s00296-025-05867-7
  23. Int J Oral Maxillofac Implants. 2025 Apr 25. 0(0): 1-30
    Research Trends and Mapping Knowledge for Short Implants in Oral and Maxillofacial Surgery.
    Ozgun Yildirim.
       PURPOSE: Short implants have become an effective alternative to conventional implants, particularly in cases with insufficient bone volume where advanced surgery may increase costs and treatment duration. Although interest in short implants is growing, a comprehensive bibliometric analysis of research trends and influential studies in this area has not been done. This analysis aims to evaluate scientific publications on short implants, identify key trends, influential authors, journals, and articles, and visualize thematic areas to guide future research.
    MATERIAL AND METHODS: The Web of Science (WoS) database was searched using the keywords ["Short Implant" OR "Short Implants" OR "Short Dental Implant" OR "Short Dental Implants"]. After applying specific inclusion criteria, 626 articles published between 1994 and 2024 were included. Bibliometric and science mapping analyses were performed using the Bibliometrix R package. Performance analysis, keyword analysis, co-citation, and thematic mapping were conducted. The PRISMA guidelines were adapted to ensure transparency and reproducibility.
    RESULTS: The analysis showed a significant increase in scientific production on short implants, with an annual growth rate of 12.69%. The average citation per article was 33.9. Clinical Oral Implants Research and the International Journal of Oral & Maxillofacial Implants were identified as the most influential journals. Esposito M. and Felice P. were the most prolific and cited authors. The most cited article was "Bone Augmentation Procedures in Implant Dentistry" by Chiapasco M. Thematic analysis revealed four major research areas and highlighted evolving trends. Despite a peak in publications in 2019, a recent decline was observed. Co-citation networks illustrated collaborations and frequently cited clusters in the field.
    CONCLUSION: This bibliometric analysis provides a comprehensive overview of the scientific landscape on short implants. The study highlights increasing interest and identifies leading authors, journals, and articles shaping the field. The findings reveal knowledge gaps and emerging themes, offering valuable insights to guide future research priorities and enhance clinical applications of short implants.
    Keywords:  Short implants; bibliometric analysis; oral and maxillofacial surgery
    DOI:  https://doi.org/10.11607/jomi.11411
  24. Health Sci Rep. 2025 Apr;8(4): e70718
    Application of Artificial Intelligence in Retinopathy of Prematurity From 2010 to 2023: A Bibliometric Analysis.
    Jing Gao, Na Fang, Yao Xu.
       Background and Aims: Retinopathy of prematurity (ROP) remains a leading cause of childhood blindness worldwide. In recent years, artificial intelligence (AI) has emerged as a powerful tool for the screening and management of ROP. This study aimed to investigate the evolving and longitudinal publication patterns related to AI in ROP using bibliometric methodologies.
    Methods: We conducted a descriptive analysis of AI in ROP documents retrieved from the Web of Science database up to September 10, 2023. Data analysis and visualization were performed using Bibliometrix and VOSviewer, covering publications, journals, authors, institutions, countries, collaboration networks, keywords, and trending topics.
    Results: Our analysis of 188 publications on AI in ROP revealed an average of 7.62 authors per document and a notable increase in annual publications since 2017. The United States (98/188), Oregon Health & Science University (66/188), Investigative Ophthalmology & Visual Science (29/188) and author Michael F. Chiang (60/188) led contributions. A prominent 21-country network emerged as the largest in country-level coauthorship. Key technical terms included "artificial intelligence," "deep learning," "machine learning," and "telemedicine," with a recent shift from "feature selection" to "deep learning," "machine learning" and "fundus images" in trending topics.
    Conclusion: Our bibliometric analysis highlights advancements in AI research on ROP, focusing on key publication characteristics, major contributors, and emerging trends. The findings indicate that AI in ROP is a rapidly growing field. Future studies should focus on addressing the clinical implementation and ethical concerns of AI in ROP.
    Keywords:  artificial intelligence; bibliometric analysis; retinopathy of prematurity
    DOI:  https://doi.org/10.1002/hsr2.70718
  25. Xenotransplantation. 2025 Mar-Apr;32(2):32(2): e70046
    Xenotransplantation: A Bibliometric Analysis of Current Trends.
    Hamzeh Feras Alshahwan, Saif Yamin, Layan Ababneh, Abdullah Alhalbouni, Muna Rommaneh, Omar Ismail, Badi Rawashdeh.
      Xenotransplantation, the transplantation of organs or tissues between species, offers a promising solution to the organ donor shortage. This study examines the research landscape of the field, identifying key trends, influential studies, and leading contributors. A search of the Scopus database on June 24, 2024, focused on solid-organ xenotransplantation publications. Articles were analyzed using Vosviewer, Bibliometrix, and Microsoft Excel. The analysis included 1072 articles with 26 066 citations, reflecting substantial impact in transplantation research. The average citations per document were 24.32, with an annual publication growth rate of 7.63%. Key sources included Xenotransplantation, Transplantation, and Transplantation Proceedings. Cooper was the most influential author, and Harvard Medical School was the leading institution. The United States dominated in publication output and citations. The most cited article, by Hering et al. (2006), had 458 citations. The study highlights the significant growth and increasing attention to xenotransplantation, with ongoing trials emphasizing its potential. This analysis provides insights into the field's progress and serves as a guide for future translational research to advance xenotransplantation toward clinical application.
    Keywords:  bibliometric; organ transplant; transplant; trends; xenotransplant
    DOI:  https://doi.org/10.1111/xen.70046
  26. Discov Oncol. 2025 Apr 21. 16(1): 583
    Mapping the landscape of metabolic reprogramming research in lung cancer: a bibliometric and visualized analysis.
    Song Han, Jialu Li, Feng Jiang, Qingtong Shi.
       BACKGROUND: Lung cancer is the leading cause of cancer-related deaths worldwide, with a poor prognosis despite advancements in diagnosis and treatment. Metabolic reprogramming, a key feature of cancer, allows tumor cells to survive and grow under harsh conditions, making it a crucial area of study. This study provides a comprehensive analysis of global trends, influential studies, and key developments in this field.
    METHODS: We conducted a bibliometric analysis using the Web of Science Core Collection (WoSCC) database from 2004 to 2024. Publications related to metabolic reprogramming and lung cancer were retrieved and analyzed using VOSviewer and CiteSpace to examine publication trends, research collaborations, keyword co-occurrence, and citation networks.
    RESULTS: A total of 1078 publications were analyzed, with research output increasing significantly after 2015. China and the United States were the leading contributors, engaging in extensive international collaborations. Pioneering studies by researchers such as Ralph J. DeBerardinis and Otto Warburg underscored the importance of altered metabolism in lung cancer. Key emerging topics included the role of cancer stem cells, changes in tumor metabolism, and new treatment approaches targeting metabolic pathways. The integration of laboratory research with clinical applications, including novel drugs and immunotherapies, demonstrated promising directions for future treatments.
    CONCLUSIONS: This bibliometric analysis maps the research landscape of metabolic reprogramming in lung cancer, identifying influential contributors and emerging research themes. Future studies should explore advanced technologies like single-cell analysis and investigate how metabolic changes are regulated at the molecular level. A deeper understanding of these processes could lead to innovative treatment strategies and better patient outcomes.
    Keywords:  Bibliometric analysis; Lung cancer; Metabolic reprogramming; Research trends; Scientometrics
    DOI:  https://doi.org/10.1007/s12672-025-02327-3
  27. Front Pharmacol. 2025 ;16 1588968
    Global research trends in biomarkers, therapeutic targets, and drugs for amyotrophic lateral sclerosis: a bibliometric and visualization analysis.
    Na Guo, Weicheng Huang, Jianliang Huang, Ying Liu, Kai Zhu, Wei Gao.
       Background: Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive degeneration of motor neurons, marked by complex pathological mechanisms and a lack of effective treatments. Despite substantial global research efforts, no comprehensive bibliometric analysis has systematically mapped the evolution of ALS biomarkers, therapeutic targets, and pharmacological advancements.
    Methods: This study, based on 4,250 publications retrieved from the Web of Science Core Collection (2005-2025), employs bibliometric tools such as CiteSpace and VOSviewer to conduct the first multidimensional analysis of global trends in ALS biomarkers, therapeutic targets, and drug research.
    Results: The results revealed contributions from 20,168 authors across 92 countries, with annual publications growing at an average rate of 16.5%. The United States dominated research output, accounting for 34.07% (n=1,448, TLCS=7,100), while the United Kingdom achieved the highest research impact with an average of 68 citations per article. Leading institutions, including the University of Oxford and the University of Milan, consistently produced high-impact studies. Pioneering scholars such as Turner MR and Kiernan MC made significant contributions to advancing therapeutic targets and drug discovery. The interdisciplinary integration of molecular biology and genetics emerged as a core driver of progress in ALS research. Neurofilament light chain (NfL), antisense oligonucleotide (ASO) drugs, transcranial magnetic stimulation (TMS), oxygen free radicals (oxidative stress), and gene therapy have consistently remained central research focuses in the ALS therapeutic field. Looking ahead, stem cell therapy, blood-brain barrier (BBB) penetration technologies, and skeletal muscle targeting are poised to emerge as prominent research directions.
    Conclusion: The United States dominates ALS research productivity, whereas the United Kingdom demonstrates superior citation influence. Despite China's substantial publication volume, its limited citation impact underscores the necessity for enhanced methodological rigor and strategic international collaboration. Current research priorities encompass NfL, TMS, and ASO therapies, with emerging innovations in stem cell therapy, BBB penetration technologies and skeletal muscle targeting showing therapeutic promise. Future directions should prioritize biomarker standardization, optimization of drug delivery systems, and Clinical Translation.
    Keywords:  amyotrophic lateral sclerosis (ALS); bibliometric analysis; blood-brain barrier penetration; interdisciplinary neurology; neurodegenerative biomarkers; skeletal muscle targeting; stem cell therapy; translational therapeutics
    DOI:  https://doi.org/10.3389/fphar.2025.1588968
  28. Front Microbiol. 2025 ;16 1558490
    Gut microbiota and gastrointestinal tumors: insights from a bibliometric analysis.
    Chaofan Chen, Xiaolan Wang, Xu Han, Lifan Peng, Zhiyun Zhang.
       Introduction: Despite the growing number of studies on the role of gut microbiota in treating gastrointestinal tumors, the overall research trends in this field remain inadequately characterized.
    Methods: A bibliometric analysis was conducted using publications retrieved from the Web of Science Core Collection (up to September 30, 2024). Analytical tools including VOSviewer, CiteSpace, and an online bibliometric platform were employed to evaluate trends and hotspots.
    Results: Analysis of 1,421 publications revealed significant geographical disparities in research output, with China and the United States leading contributions. Institutionally, the University of Adelaide, Zhejiang University, and Shanghai Jiao Tong University were prominent contributors. Authorship analysis identified Hannah R. Wardill as the most prolific author, while the International Journal of Molecular Sciences emerged as a leading journal. Rapidly growing frontiers include "proliferation," "inhibition," "immunotherapy," "drug delivery," and "tumorigenesis."
    Discussion: This study provides a comprehensive overview of research trends and highlights emerging directions, aiming to advance scientific and clinical applications of gut microbiota in gastrointestinal tumor therapy.
    Keywords:  CiteSpace; VOSviewer; emerging research trends; gastrointestinal tumors; gut microbiota; immunotherapy
    DOI:  https://doi.org/10.3389/fmicb.2025.1558490
  29. Discov Oncol. 2025 Apr 24. 16(1): 600
    A global bibliometric map of Mendelian randomization in lung cancer research: trends, themes, and emerging risks.
    Chong-Qi Fan, Yao-Xuan Chen, Feng Guo, Hao-Han Rao, Chun-Jian Zuo, Peng-Yu Che, Cao Yu, Huan-Wen Chen.
       BACKGROUND: Although Mendelian randomization (MR) studies on lung cancer (LC) have grown significantly, a comprehensive bibliometric analysis remains lacking. This study addresses that gap by examining global research trends, leading contributors, and emerging themes in MR related to LC.
    METHODS: We conducted a bibliometric analysis of publications from 2005 to 2024, using data from the Web of Science Core Collection. Research trends, collaboration networks, and key themes were visualized with VOSviewer, CiteSpace, and the R package 'bibliometrix'.
    RESULTS: The analysis included 332 publications by 2,797 researchers across 50 countries. A notable increase in studies occurred after 2017, with China, the United States, and England as the top contributors. Key institutions included the University of Bristol and Nanjing Medical University. The most productive journals were Cancer Epidemiology, Biomarkers & Prevention and International Journal of Epidemiology, while Nature Genetics was the most cited. The research identified multiple causal pathways for LC linked to inflammation, genetics, lifestyle factors, lung diseases, and psychiatric conditions. Emerging themes include the roles of gut microbiota, schizophrenia, C-reactive protein, and asthma in LC development.
    CONCLUSION: This bibliometric analysis of MR studies on LC highlights global research trends and emerging areas, particularly the roles of gut microbiota, schizophrenia, and inflammation in LC risk. These insights lay a strong foundation for advancing personalized prevention and treatment in future MR studies.
    Keywords:  Bibliometric analysis; Lung cancer; Mendelian randomization; Research trend
    DOI:  https://doi.org/10.1007/s12672-025-02368-8
  30. Front Oncol. 2025 ;15 1587252
    Research status and frontiers in liver cancer immunotherapy: a bibliometric perspective on highly cited literature.
    Pan Su, Yeqiong Han, Jindong Yi, Yu Hou, Yao Xiao.
       Background: Liver cancer is one of the major causes of cancer-related death in the world. As a breakthrough therapy, immunotherapy had significantly improved the prognosis of patients. However, the current research status and research hotspots in the field of liver cancer immunotherapy still lack systematic review. Based on the bibliometric analysis of highly cited papers, this study intended to reveal the current research status, research hotspots and future research trends in this field.
    Objective: The purpose of this study was to analyze the national/regional contributions, authors and institutions cooperation network, keywords clustering and keywords burst analysis of highly cited papers on liver cancer immunotherapy through bibliometrics, so as to clarify the research frontier and development direction, and provide objective data support for future research direction and clinical practice.
    Methods: The highly cited papers on liver cancer immunotherapy from the Web of Science core collection up to February 23, 2025 were retrieved, and 232 studies were included. CiteSpace was used to build a knowledge map, analyze the distribution of years, countries, authors, institutions and cooperation networks, and identify research hotspots and emerging trends through keyword clustering and burst detection.
    Results: The number of highly cited papers continued to increase from 2014 and reached a peak in 2022. China and the United States had the highest number of publications and the centrality of cooperation networks. The author with the highest number of papers was Llovet, Josep M, whose research direction mainly focused on immune checkpoint inhibitor combination therapy and molecular typing. The author with the highest cooperation network centrality was Duda, Dan G, whose research team focused on tumor microenvironment regulation. Harvard University and the University of Barcelona played an important central role in the institutional collaboration. Keywords analysis showed that immune checkpoint inhibitors, tumor microenvironment and combination therapy were the core of liver cancer immunotherapy. Burst keywords such as cell lung cancer, pembrolizumab, advanced melanoma, blockade, lymphocytes, etc. had revealed the research frontier of liver cancer immunotherapy research.
    Conclusion: The research on liver cancer immunotherapy had made multi-dimensional progress, with China and the United States leading the global cooperation. The main research directions were the combination strategy of immunization, the regulation of tumor microenvironment and the exploration of novel targets. In the future, it is necessary to optimize treatment resistance solutions, integrate interdisciplinary resources, and promote the development of precision and personalized treatment.
    Keywords:  CiteSpace; bibliometrics; frontier; hotspot; immunotherapy; liver cancer (LC)
    DOI:  https://doi.org/10.3389/fonc.2025.1587252
  31. Sports (Basel). 2025 Mar 24. pii: 93. [Epub ahead of print]13(4):
    Mapping the Knowledge of Research Trends in Sports Performance Asymmetries from 2015 to 2024: A Bibliometric Study and Analysis of the Most-Cited Papers.
    Boryi A Becerra-Patiño, Juan David Paucar-Uribe, Jorge Olivares-Arancibia, Alex Ojeda-Aravena, Rodrigo Yáñez-Sepúlveda, José M Gamonales, José Francisco López-Gil, Víctor Hernández-Beltrán.
      In recent years, studies related to preventing injuries and improving sports performance have aroused academic interest. However, no bibliometric study has investigated asymmetry. The aim of this study was twofold: (i) to identify trends in research on asymmetries in sports performance through bibliometric analysis, and (ii) to determine the most-cited articles to establish the main lines of research on asymmetries. The final sample consisted of 471 documents. The results show that, during the publication period, there was a considerable increase (73%) in research between 2020 and 2021, with 2022-2023 being the year with the highest production and number of citations. Most of the publications consisted of research articles (93.41%), with a low percentage of review studies (4.24%). The Journal of Strength and Conditioning Research and Symmetry were the journals with the highest number of documents (n = 57) and citations (n = 1230). The journals that produced the most knowledge were those in the first quartile (Q1) and the second quartile (Q2). The most prolific author was Bishop, C. The countries with the highest number of published documents were England (140 documents and 3039 citations) and the United States (94 documents and 2099 citations). The most common words in the studies were performance (n = 162), strength (n = 167), reliability (n = 118), injury (n = 94), and asymmetry (n = 90). The study of asymmetries in sports performance has focused on two main approaches: one related to analyzing differences between limbs, and the other focused on assessing strength after postoperative processes. The analysis of the existing body of knowledge on asymmetries allows us to incorporate the latest scientific advancements. In turn, this helps us to establish best practices to enhance both sports performance and rehabilitation processes.
    Keywords:  asymmetry; dominance; interlimb strength; limb differences; muscular speed; performance
    DOI:  https://doi.org/10.3390/sports13040093
  32. Front Pharmacol. 2025 ;16 1520055
    A bibliometric and visual analysis based on immune checkpoint inhibitors for hepatocellular carcinoma: 2014 - 2024.
    Gao-Min Liu, Rui Guo, Ji-Wei Xu.
       Background: Immune checkpoint inhibitors (ICIs) have changed the treatment landscape of hepatocellular carcinoma (HCC), especially those with unresectable advanced stages. The field has progressed rapidly, and the research hotspots have significantly changed compared to previous years. The study aims to comprehensively review and analyze the development history, knowledge structure, current research focus, and emerging trends in ICIs for HCC.
    Materials and methods: Reviews and articles published in English from The Web of Science Core Collection (WoSCC) database from 2014 to 2024 were systemically retrieved. Citespace, VOSviewer, and Bibliometrix R package were used for further bibliometric analysis and visualization for countries, institutions, authors, references, and keywords.
    Results: 2,941 records were included for analysis. The literature on ICIs for HCC has continued to grow steadily over the past decade. Three major research centers have emerged: North America, Europe, and East Asia. The Chinese institution has the highest publication volume, but Kudo Masatoshi from Japan has the highest number of publications. At the same time, Richard S. Finn from the United States leads in citations and co-citations. The most prolific journal is "Cancers". The clustering and Timeline view of critical literature and keywords indicated that research on ICIs for HCC is rapidly advancing toward a more evidence-based, personalized, and multimodal approach. Immune evasion mechanisms, predictive biomarkers, and high-quality clinical trials focusing on Novel combination, conversion, and perioperative therapies, including ICIs, are emerging hotspots.
    Conclusion: This study highlights the groundbreaking advancements of ICIs in treating HCC and shows a trend rapidly advancing towards a more evidence-based, personalized, and multimodal approach. The study updated the current understanding of ICIs in hepatocellular carcinoma and identified vital future directions for research, such as the exploration of mechanisms of immune evasion, developing predictive biomarkers, and combining therapy strategies.
    Keywords:  HCC; R; VOSviewer; bibliometric; citespace; immune checkpoint inhibitors
    DOI:  https://doi.org/10.3389/fphar.2025.1520055
  33. Saudi Med J. 2025 Apr;46(4): 406-417
    A bibliometric analysis of disability research in Saudi Arabia: Evolving trends, thematic mapping, and gaps.
    Mahmoud Kandeel, Mohamed A Morsy, Khalid M Al Khodair, Sameer Alhojaily.
       OBJECTIVES: To identify key trends and influential authors and institutions, provide thematic mapping, and determine recent evolutions and gaps in the disability research in Saudi Arabia.
    METHODS: The study started in June 2024 and the data was analyzed during July 2024 in Al-Ahsa, Saudi Arabia. The analysis employed bibliometric techniques such as bibliometric coupling, and thematic mapping using VOSviewer and RStudio with the Bibliometrix package.
    RESULTS: The bibliometric analysis identified a total of 3080 publications and showed that the annual growth rate in the number of publications was 13.5%. Emerging themes included intellectual disabilities, quality of life, rehabilitation, and mental health. Additionally, there was a significant increase over the years in studies incorporating modern technologies such as machine learning and artificial intelligence. International collaborations were significant, at 59.2% of the publications. Density visualization highlighted central themes such as multiple sclerosis and quality of life. Emerging themes such as machine learning and virtual reality reflected recent trends that integrated advanced technologies into disability research. Several gaps were found, particularly in foundational themes and information on the practical applications of the emerging technologies for disabled people.
    CONCLUSION: The bibliometric analysis highlighted a diverse landscape of disability research in Saudi Arabia. Future research should explore the practical applications of advanced technologies in the Saudi context to improve the quality of life for individuals with disabilities.
    Keywords:  Saudi Arabia; bibliometric analysis; disability; research themes; research trends
    DOI:  https://doi.org/10.15537/smj.2025.46.4.20240591
  34. Front Aging Neurosci. 2025 ;17 1542607
    Alzheimer's disease and insomnia: a bibliometric study and visualization analysis.
    Zi-Yue Tian, Bing Jiang, Meng Jin, Xiao-Kun Yu, Qi-Lin Chen, Jia-Hui Wang.
       Background: Alzheimer's disease (AD) is the fastest-growing neurodegenerative disorder globally, with patient numbers expected to rise to 130 million by 2050. Insomnia, a prevalent comorbidity, exhibits a bidirectional relationship with AD: insomnia accelerates AD pathology, while AD worsens sleep disorders. This relationship has emerged as a key area of research. Current mechanisms involve oxidative stress, inflammatory responses, and glymphatic system dysfunction, yet a comprehensive review of these processes remains absent.
    Objective: To conduct a visual analysis of the relationship between Alzheimer's disease and insomnia using CiteSpace.
    Methods: Literature on "insomnia" and "Alzheimer's disease" published between January 1, 2000, and October 31, 2024, was retrieved from the Web of Science Core Collection. CiteSpace and VOSviewer software were used to analyze institutions, authors, and keywords.
    Results: A total of 1,907 articles were analyzed, revealing a consistent upward trend in publication volume. The United States and the Mayo Clinic were identified as leading contributors, producing 704 and 57 publications, respectively. Boeve Bradley F the most prolific author contributed 30 publications. Collaboration was actively observed among countries, institutions, and authors. High-frequency keywords identified were "Parkinson's disease," "cognitive impairment," and "sleep behavior disorder." Emerging research areas are likely to focus on "sleep quality" and the "glymphatic system."
    Conclusion: This study is the first to apply bibliometric analysis to identify three key trends in AD and insomnia research: the dominance of the United States and Mayo Clinic, strong international collaboration, and a focus on critical areas such as cognitive impairment, the glymphatic system, and sleep interventions. Insomnia may accelerate AD progression via multiple pathways, indicating that enhancing sleep quality could provide new strategies for early intervention. Future research should prioritize advancing the clinical translation of sleep interventions and investigating the mechanisms of the glymphatic system.
    Keywords:  Alzheimer's disease; CiteSpace; VOSviewer; bibliometrics; insomnia; visual analysis
    DOI:  https://doi.org/10.3389/fnagi.2025.1542607
  35. F1000Res. 2024 ;13 1320
    A global overview of the use of cone beam computed tomography in dentistry: a bibliometric review focusing on paediatric patients.
    Danielle Cristina Alves Rigo, Aurélio de Oliveira Rocha, Lucas Menezes Dos Anjos, Pablo Silveira Santos, Isabela Ramos, Michely Cristina Goebel, Julia Maldonado Garcia, Gabriela Beatriz Rigo Wietzkoski, Carla Miranda Santana, Mariane Cardoso.
       Background: Cone Beam Computed Tomography (CBCT) has improved diagnosis and treatment planning in paediatric dentistry, but no bibliometric studies have examined the research landscape. This study provides an overview regarding the role of CBCT in paediatric dentistry.
    Methods: A bibliometric review was conducted using articles from the Web of Science database. The search was performed on 22 February 2024, including publications up to that date. Conference papers and editorials were excluded. Data extracted included citation counts, publication dates, journals, impact factors, study designs, topics, geographical and institutional affiliations, authors, and keywords. Collaborative networks were visualised using VOSviewer, and Spearman's correlation assessed the relationship between citation counts and other variables.
    Results: The review analysed 517 articles, with the most cited receiving 557 citations. Publication dates ranged from 2005 to 2024, with a peak in 2023. Observational studies were the most common, particularly on maxillary expansion. The American Journal of Orthodontics and Dentofacial Orthopedics was the most cited journal, and the USA was a major contributor. Jacobs R authored the most articles (n=19), and the University of Alberta led in institutional output. Spearman's correlation showed a weak positive correlation between citation count and journal impact factor (rho=0.272, p<0.001) and a strong negative correlation with publication year (rho=-0.762, p<0.001).
    Conclusions: This bibliometric review provides an overview of the use of CBCT in paediatric dentistry, particularly in maxillary expansion. The findings suggest that more specific imaging protocols may improve safety and clinical outcomes, and that further investigation of long-term outcomes may provide valuable insights.
    Keywords:  Bibliometric Analysis; CBCT; Cone-Beam Computed Tomography; Dentistry; Paediatric
    DOI:  https://doi.org/10.12688/f1000research.157349.2
  36. Diagn Microbiol Infect Dis. 2025 Apr 20. pii: S0732-8893(25)00187-7. [Epub ahead of print]112(4): 116864
    A bibliometric and visual analysis of the research status and hotspots of Pulmonary Aspergillosis based on web of science.
    Jianye Li, Qingjun Zhu, Huixin Yan, Ting Ma, Yun An.
       BACKGROUND: Pulmonary Aspergillosis (PA) is a common fungal lung infection. Despite recent advancements, bibliometric studies on PA are scarce. This study uses bibliometric methods to analyze current research trends and key topics, offering insights into future directions in the field.
    METHODS: PA-related literature was retrieved from the Web of Science Core Collection (WOSCC) database, and detailed analysis was conducted using CiteSpace, VOSviewer, and Excel 2019 software. This analysis aimed to identify trends and hot topics in the field of PA.
    RESULTS: A total of 1,715 articles were analyzed from 1900 to 2024. The number of publications has shown steady growth, with a gradual increase from 1990 to 2019, followed by a sharp rise after 2019. The United States leads in this field. The main research hotspots and frontiers in PA include: the close association between PA and immunocompromised conditions, COVID-19 as a new risk factor for PA, and current clinical research focusing on antifungal treatments and enhancing host immunity.
    CONCLUSION: This study reveals trends in PA research, notably the sharp increase in publications post-2019. Novel findings include the identification of COVID-19 as a new risk factor for PA and the growing emphasis on antifungal treatments and host immunity enhancement. These insights provide a clearer direction for future clinical and research priorities in PA.
    Keywords:  Bibliometric; CiteSpace; Pulmonary Aspergillosis; VOSviewer; Visual analysis
    DOI:  https://doi.org/10.1016/j.diagmicrobio.2025.116864
  37. Ann Surg Oncol. 2025 Apr 23.
    Mapping Knowledge Landscapes and Themes Trends of Breast Cancer Stem Cells: A Comprehensive Data-Mining-Based Study.
    Kunming Cheng, Hui Di, Chunchun Wu, Hongjie Zhao, Wanqing Li.
       BACKGROUND: Breast cancer, one of the most prevalent malignancies affecting women, poses significant treatment challenges due to the presence of breast cancer stem cells (BCSCs), which may contribute to treatment resistance, recurrence, and metastasis. Targeting BCSCs is increasingly seen as a promising therapeutic approach and a series of BCSC-related studies have been published recently. Nevertheless, no study has yet employed bibliometric analysis to examine the overall landscape of BCSC research.
    MATERIALS AND METHODS: All BCSC-related papers published between 1998 and 2023 were extracted from Web of Science Core Collection database. Bibliometric analysis was conducted by using VOSviewer, CiteSpace, and two online platforms.
    RESULTS: A sum of 1771 papers including 1502 research articles and 269 review papers were ultimately included. The annual number of papers related to BCSCs has increased with the year, and the average annual growth rate during 1998 and 2023 was 18.4%. China and the USA undoubtedly dominate on a global scale, accounting for more than three-fifths of all publications. The University of Michigan System has published the most papers in this area. On the basis of the results from highly cited studies and high-frequency keywords, the research hotspots of BCSCs currently focus on domains including stemness and membrane biomarkers, key signaling pathways and molecules, therapeutic targeting and plasticity, therapeutic resistance, tumor characteristics, and microenvironment. In addition, the findings from keywords co-occurrence and burst analysis implied that research areas such as ferroptosis, GLI1, molecular docking, glycolysis, tumor microenvironment, copper, RUNX2, hyaluronic acid, cytokines, NANGO, long non-coding RNAs, triple-negative breast cancer, nanoparticles, Hippo pathway, and T cells warrant ongoing attention in the future. Additionally, TGFB1, STAT3, MYC, GAPDH, and INS were identified as the top five genes receiving the highest research focus within BCSC studies.
    CONCLUSIONS: This is the first study to comprehensively map the current state and global emerging trends in BCSC research through a bibliometric analysis. These findings provide a comprehensive overview of BCSC research and may serve as a useful reference for scholars and policymakers to identify emerging trends and prioritize future research directions in this field.
    Keywords:  Bibliometrics; Breast cancer; Cancer stem cells; CiteSpace; Hotspots; VOSviewer
    DOI:  https://doi.org/10.1245/s10434-025-17336-3
  38. Discov Oncol. 2025 Apr 24. 16(1): 609
    Knowledge map of programmed cell death in esophageal cancer: a bibliometric analysis.
    Rulin Li, Yanchun Yang, Yang Gao, Jing Lv, Chuanqiang Dai, Yuanwei Zhai, Chirong Mao, Jiudong Jiang, Jiangang Fan, Yang Yu, Liang Wu, Zhiwu Lin.
       OBJECTIVES: This study aimed to delineate the evolving knowledge structure of programmed cell death in esophageal cancer and identify key thematic trends, influential collaborations, and emerging areas for future research.
    METHODS: A bibliometric approach was applied to 2677 publications retrieved from the Web of Science Core Collection (2000-2024). Three complementary tools-CiteSpace, VOSviewer, and bibliometrix-were employed to visualize co-citation networks, detect citation bursts, and map collaborative patterns among authors, institutions, and countries. Inclusion criteria focused on articles and reviews that addressed esophageal cancer in conjunction with apoptosis, necroptosis, pyroptosis, ferroptosis, autophagy, or related pathways.
    RESULTS: Publication outputs grew markedly, reflecting a shift from early investigations of basic apoptotic mechanisms to broader explorations of necroptosis, pyroptosis, and ferroptosis. China led in publication volume and citations, driven by substantial governmental funding and large clinical cohorts. The United States and Japan also contributed significantly, forming international research networks that spanned Asia and Europe. Leading institutions, particularly Zhengzhou University, demonstrated extensive collaborations. Journals such as Oncology Letters and Oncology Reports were prominent outlets for new findings, while highly cited references highlighted hypoxia, immune checkpoint blockade, and emerging gene-editing strategies. Keyword analyses revealed the ascendance of immuno-oncology, network pharmacology, and translational applications targeting multiple regulated cell death pathways.
    CONCLUSION: Bibliometric evidence underscores a rapid expansion of multidisciplinary research that integrates diverse cell death pathways in esophageal cancer. Continued international collaborations, leveraging advanced genomics and immunologic strategies, are poised to accelerate translational breakthroughs and enable more personalized, effective therapies.
    Keywords:  Apoptosis; Autophagy; Esophageal cancer; Necroptosis; Programmed cell death
    DOI:  https://doi.org/10.1007/s12672-025-02376-8
  39. J Asthma. 2025 Apr 20. 1-17
    Bibliometric Perspectives on Inflammatory and Immunological Research in Pediatric Asthma.
    Danqing Hu, Ling Mei, Dongyang An, Zengyu Zhang, Yugen Sha, Wei Zhou.
       OBJECTIVE: Pediatric bronchial asthma, a prevalent chronic inflammatory respiratory disease, significantly affects children globally. However, bibliometric analyses focused on its inflammatory and immunological aspects are limited. This study aims to provide an overview of the field, identify key focus areas, and predict emerging trends.
    METHODS: We collected and analyzed relevant literature published from January 1, 2000, to May 31, 2024, from the Web of Science Core Collection. Collaborative network analysis was conducted using CiteSpace 5.8.R3, VOSviewer 1.6.20, and Bibliometrix.
    RESULTS: A total of 911 papers were retrieved, showing growth in research output since 2006, with the United States leading in publications. The University of Western Australia ranks first in publication count, while the University of Wisconsin-Madison has the highest average citations per paper. Among 5,059 authors, 146 core authors contributed to 592 articles, accounting for 64.98% of total publications, with Anne M. Fitzpatrick as the leading author. The journal "Allergy, Asthma & Immunology Reviews" is the most influential, and "asthma" is the most cited keyword. Co-citation analysis reveals 20 keyword clusters, with hotspots including "efficacy" and "allergic rhinitis." The most cited paper is by D. P. Strachan in the "British Medical Journal."
    CONCLUSION: This study reveals a significant increase in pediatric asthma research from 2000 to 2024, with the U.S. leading in scholarly contributions. Key findings highlight allergic airway inflammation and type 2 inflammation as primary mechanisms underlying the disease. Inhaled corticosteroids and biologics are identified as effective treatments. These insights emphasize the importance of global collaboration and ongoing research efforts to advance understanding of pathogenic mechanisms and clinical management in pediatric asthma patients.
    Keywords:  Hotspots；Bibliometric analysis；CiteSpace；VOSviewer; Inflammation and Immunology; Pediatric asthma
    DOI:  https://doi.org/10.1080/02770903.2025.2494231
  40. Bioimpacts. 2025 ;15 30401
    Bibliometric study of BioImpacts using a technological impact approach.
    Leila Mirzapour, Fatemeh Sheikhshoaei.
      
    Introduction: The number of citations received by articles is a key indicator of a journal's quality and effectiveness within its field. This, in turn, influences the ability to secure funding for ongoing publication, establishing a suitable policy for its promotion, and helping researchers selecting an appropriate journal to publish their findings or find information they require. Meanwhile, one way to measure a journal's technological impact is to examine the patent citations attached to its articles. This study aims to evaluate the technological impact of BioImpacts (BI) by examining the patents' citations to its articles.
    Methods: This descriptive study was conducted using the bibliometric method with a technological impact approach. The published BI belonged to the years 2011-2023. Data were extracted using the Lens and Espacenet databases. Descriptive statistics and Excel software were applied for data analysis.
    Results: The results revealed that BI had a 10% technological impact. Original research contributed to most of the cited articles (27). American patents were the most impacted by BI's articles. Moreover, human necessities (A) and chemistry and metallurgy (C) were two main technological sections influenced by BI's articles. The most active and influential country was Iran and the most active and influential organization was Tabriz University of Medical Sciences.
    Conclusion: Based on the present research findings, the technological impact of BI is considerable; so, it is important to present information about this issue on the journal's website and adopt appropriate policies for further development of BI in this field.
    Keywords:  Bibliometric study; BioImpacts; Patent citation; Technology impact
    DOI:  https://doi.org/10.34172/bi.30401
  41. Front Med (Lausanne). 2025 ;12 1527246
    Global trends and interdisciplinary insights in Tai Chi research: a bibliometric analysis (2004-2024).
    Bei Li, Xiwei Zhu, Haoli Zhang, Su Zhang, Yanwei Li, Shuxi Wu, Jie Han.
       Background: Tai Chi, as a traditional Chinese martial art, has received extensive attention in recent years due to its multiple health benefits. Research demonstrates that Tai Chi improves physical health, enhances flexibility and coordination, and alleviates psychological stress. With the increase in research, the health benefits of Tai Chi have been confirmed by many scientific studies. Therefore, a bibliometric analysis of Tai Chi literature can help us better understand the research status and development trends in this field.
    Methods: The article and commentary on Tai Chi from 2004 to 2024 were retrieved from the Web of Science Core Collection. We used the bibliometric.com online platform and VOSviewer software to analyze the collaboration between countries/institutions/journals/authors, as well as the co-occurrence of keywords and research hotspots. Disciplinary distribution was analyzed using Web of Science subject categories, and visualized through VOSviewer's clustering algorithm.
    Results: From 2004 to 2023, the number of research papers related to Tai Chi showed an overall upward trend, with a 12.3% average annual growth rate post-2012. China contributed 68.5% of publications (n = 645/941), followed by the United States (15.2%, n = 143). Key findings include a 40% reduction in fall risk (RR = 0.60, 95% CI: 0.52-0.69) and a 33% improvement in sleep quality (p < 0.001) among elderly practitioners. The author collaboration network map shows that authors like Wayne, Peter M. have significant influence in the field of Tai Chi research. Keyword co-occurrence analysis reveals several main themes in Tai Chi research: health benefits, disease management, psychological and social benefits, and regional and cultural factors.
    Conclusion: Tai Chi research is growing globally, and its potential health benefits are increasingly recognized. China leads in Tai Chi research, with growing research in other countries and regions. Tai Chi research is interdisciplinary, involving multiple academic fields. Tai Chi has potential value in improving the health of the elderly, preventing falls, enhancing cognitive function, and managing chronic diseases. Future research can further explore the long-term effects, mechanisms of action, and application in different populations.
    Keywords:  Tai Chi; VOSviewer; bibliometric; global trends; interdisciplinary
    DOI:  https://doi.org/10.3389/fmed.2025.1527246
  42. Vaccines (Basel). 2025 Feb 26. pii: 240. [Epub ahead of print]13(3):
    Respiratory Vaccines in Older Adults: A Bibliometric Analysis and Future Research Agenda.
    Jose F Parodi, Fernando Runzer-Colmenares, Carlos Cano-Gutiérrez, José Luis Dinamarca-Montecinos, Patricio Bendía-Gomez de La Torre, Paulo Fortes Villas Boas, Javier Flores-Cohaila, Diego Urrunaga-Pastor, Luis Miguel Gutiérrez-Robledo.
       BACKGROUND/OBJECTIVES: Respiratory infections impact older adults due to immunosenescence and comorbidities, resulting in increased healthcare costs and mortality. While vaccination is a critical preventive measure, research on respiratory vaccines in older adults in Latin America and the Caribbean (LAC) remains underexplored. This study aims to map the research landscape and identify emerging themes to guide future studies.
    METHODS: A bibliometric analysis was conducted using the Web of Science database, focusing on publications up to 2023 related to respiratory vaccines in LAC's older adult population. PRISMA-ScR guidelines were followed for data extraction and analysis, with performance metrics and scientometric mapping conducted using Biblioshiny 4.1 and VOSviewer.
    RESULTS: Ninety-nine studies spanning forty-one journals and 575 authors were included. Brazil contributed 70% of publications, followed by Mexico and Argentina. Influenza and pneumococcal vaccines were the most studied, focusing on coverage, acceptance, and cost-effectiveness. Emerging themes included COVID-19 vaccine effectiveness and vaccination-associated factors. Brazil was identified as the primary hub for collaboration across the region, while other countries made limited contributions.
    CONCLUSIONS: The findings highlight disparities in research output, with Brazil dominating and significant gaps in other LAC countries. Future research should prioritize genomic studies, vaccine efficacy in comorbid populations, and adaptive immunization strategies. Building research capacity and fostering international collaborations are essential for improving vaccination outcomes in older adults across LAC.
    Keywords:  COVID-19; Latin America; bibliometric analysis; influenza; older adults; pneumococcal; respiratory vaccines
    DOI:  https://doi.org/10.3390/vaccines13030240
  43. Interact J Med Res. 2025 Apr 23. 14 e65844
    Exploring 97 Years of Aedes aegypti as the Vector for Dengue, Yellow Fever, Zika, and Chikungunya (Diptera: Culicidae): Scientometric Analysis.
    Yoon Ling Cheong, Sumarni Mohd Ghazali, Mohd Hazilas Mat Hashim, Mohd Khairuddin Che Ibrahim, Afzufira Amran, Tsye Yih Tiunh, Hui Li Lim, Yong Kang Cheah, Balvinder Singh Gill, Kuang Hock Lim.
       BACKGROUND: Aedes aegypti is an important vector that transmits dengue, Zika, chikungunya, and yellow fever viruses. Although research on Aedes aegypti has been conducted for decades, scientometric studies on Aedes aegypti are scarce, are limited to regions, and cover short periods. Thus, there is still a knowledge gap in the current trend, research focuses and directions, leading authors and collaboration, journal and citation impacts, countries, and worldwide collaborations.
    OBJECTIVE: The objectives of the study are to investigate the research trend, focus and directions, citation impact, leading authors and collaboration, journals, and countries of the published works on Aedes aegypti to inform the current knowledge gaps and future direction of the control of the vector.
    METHODS: In this study, we searched the Scopus database for articles on Aedes aegypti published from the year 1927 until April 5th, 2024, and included articles, reviews, books, and book chapters that were written in English. A total of 16,247 articles in 160 journals with 481,479 citations were included. Inconsistencies in authors' names were checked and cleaned using OpenRefine. The data were grouped into 4 periods; years 1927-1999, 2000-2009, 2010-2019, and 2020-2023. The relative growth rate and doubling time of publications were calculated. The analysis was conducted using VOSviewer, R bibliometrics, and citeSpace.
    RESULTS: The overall RGR was 0.1. Doubling time increased from 9.3 in 1978-1998 to 12.1 in 2000-2009. The main research clusters were "using Wolbachia," "Dengue Zika," "worldwide diversity," "community support," "larvicidal activity," "mosquito genotype-dependent," and "sterile insect technique." Journal of Medical Entomology was the leading journal (758/16,247, 4.7%). The most cited articles were authored by Halstead SB and team in Science (N=1355) and Kraemer MU and team in eLife (N=1324). The United States (5806/23,538, 24.7%) and Brazil (2035/23,538, 8.6%) were the top countries. Gubler DJ was the top co-cited author (n=2892) from 2000 to 2019. The co-cited author cluster patterns informed the significant specialty research on Aedes aegypti across time. Authors from various specialized research fields tended to collaborate across countries, especially neighboring countries. Countries with more research funding on the study of Aedes aegypti published more papers.
    CONCLUSIONS: Researchers or entomologists could understand the current knowledge gap on Aedes aegypti and plan for future research pathways. This study contributed to the public health stakeholders in improving the vector control interventions and elucidated the extent of research subject areas.
    Keywords:  Aedes aegypti; Scopus; Zika; author; bibliometric; co-occurrence; collaboration index; dengue; relative growth rate; vector control
    DOI:  https://doi.org/10.2196/65844
  44. BJA Open. 2025 Jun;14 100397
    Trends in paediatric anaesthesia research publications and the impact of author sex, country of origin, topic, and external funding.
    Andy Jeon, Aine Sommerfield, Britta S von Ungern-Sternberg.
       Background: The current research landscape has become increasingly competitive with approximately 35% of submitted manuscripts accepted for publication by peer-review journals. It is known that studies with certain 'favourable characteristics' have an increased likelihood of acceptance for publication, such as prospective study design, multiple sites, and notable authors.We aimed to identify the characteristics of original research publications in paediatric anaesthesiology and the impact of these characteristics on citations. The characteristics selected were study design, topic choice, region of origin, sex of authors (as defined by first name), and presence of external funding.
    Methods: This bibliometric study reviewed all paediatric anaesthesiology original research articles published between 2012 and 2021 from five high-impact general anaesthesiology journals and from the subspecialty's top-ranking specialist journal, Pediatric Anaesthesia. Original research articles (n=1119) were independently assessed by two investigators for the following characteristics: primary research topic, study design, region of origin, number of sites involved, external funding status, sex of first and last author, and number of citations.
    Results: The principal findings in our study showed that highly cited articles in paediatric anaesthesiology were more likely to display publication characteristics such as prospective study design (66% vs 61%), multi-site (23%% vs 14%), and being externally funded (53% vs 46%).
    Conclusions: Our report highlights the need to consider consumer priorities for research, to encourage collaboration across institutions, and to generally improve access to funding for paediatric anaesthesiology research. In addition, the findings underline the already recognised need to reach better sex equality in academic paediatric anaesthesiology publications.
    Keywords:  bibliometric; paediatric anaesthesia; publication characteristics; research funding; research topic
    DOI:  https://doi.org/10.1016/j.bjao.2025.100397
  45. Hum Vaccin Immunother. 2025 Dec;21(1): 2493539
    Mapping the rapid growth of multi-omics in tumor immunotherapy: Bibliometric evidence of technology convergence and paradigm shifts.
    Huijing Dong, Xinmeng Wang, Yumin Zheng, Jia Li, Zhening Liu, Aolin Wang, Yulei Shen, Daixi Wu, Huijuan Cui.
      This study aims to fill the knowledge gap in systematically mapping the evolution of omics-driven tumor immunotherapy research through a bibliometric lens. While omics technologies (genomics, transcriptomics, proteomics, metabolomics)provide multidimensional molecular profiling, their synergistic potential with immunotherapy remains underexplored in large-scale trend analyses. A comprehensive search was conducted using the Web of Science Core Collection for literature related to omics in tumor immunotherapy, up to August 2024. Bibliometric analyses, conducted using R version 4.3.3, VOSviewer 1.6.20, and Citespace 6.2, examined publication trends, country and institutional contributions, journal distributions, keyword co-occurrence, and citation bursts. This analysis of 9,494 publications demonstrates rapid growth in omics-driven tumor immunotherapy research since 2019, with China leading in output (63% of articles) yet exhibiting limited multinational collaboration (7.9% vs. the UK's 61.8%). Keyword co-occurrence and citation burst analyses reveal evolving frontiers: early emphasis on "PD-1/CTLA-4 blockade" has transitioned toward "machine learning," "multi-omics," and "lncRNA," reflecting a shift to predictive modeling and biomarker discovery. Multi-omics integration has facilitated the development of immune infiltration-based prognostic models, such as TIME subtypes, which have been validated across multiple tumor types, which inform clinical trial design (e.g. NCT06833723). Additionally, proteomic analysis of melanoma patients suggests that metabolic biomarkers, particularly oxidative phosphorylation and lipid metabolism, may stratify responders to PD-1 blockade therapy. Moreover, spatial omics has confirmed ENPP1 as a potential novel therapeutic target in Ewing sarcoma. Citation trends underscore clinical translation, particularly mutation-guided therapies. Omics technologies are transforming tumor immunotherapy by enhancing biomarker discovery and improving therapeutic predictions. Future advancements will necessitate longitudinal omics monitoring, AI-driven multi-omics integration, and international collaboration to accelerate clinical translation. This study presents a systematic framework for exploring emerging research frontiers and offers insights for optimizing precision-driven immunotherapy.
    Keywords:  Omics; bibliometric analysis; tumor immunotherapy
    DOI:  https://doi.org/10.1080/21645515.2025.2493539
  46. Front Physiol. 2025 ;16 1516466
    Mapping the future: bibliometric insights into ferroptosis and diabetic nephropathy.
    Tangwen Wei, Yang Qin, Xiaohui Lin, Xiujuan Wang, Suyi Chen, Xia Chen, Nan Yan, Xinyi Wei, Zhichang Zhang, Bing Wei.
       Background: Diabetic nephropathy (DN), a leading cause of end-stage renal disease, exerts a substantial burden on healthcare systems globally. Emerging evidence highlights ferroptosis - an iron-dependent form of cell death driven by lipid peroxidation and glutathione depletion - as a critical contributor to DN progression via oxidative stress, tubular injury, and glomerular dysfunction. Despite increasing research interest, a comprehensive synthesis of research trends and mechanistic insights is lacking.
    Objective: This study integrated bibliometric analysis with a mechanistic review to map the evolving ferroptosis landscape in DN, identify research hotspots, and propose future directions for therapeutic development.
    Methods: In total, 86 publications (2018-2023) were retrieved from the Web of Science Core Collection and analyzed using CiteSpace and VOSviewer. Co-occurrence networks, citation trends, and keyword bursts were examined to delineate global contributions, collaborative networks, and emerging themes.
    Results: Annual publication numbers surged 12-fold after 2020, with China contributing the highest proportion (60.4%), and led by institutions such as Zhengzhou University. The United States of America and Germany showed high centrality in collaborative networks. Key research themes included glutathione peroxidase 4 (GPX4)-mediated antioxidant defenses, acyl-CoA synthetase long-chain family member 4 (ACSL4)-mediated lipid remodeling, and iron dysregulation. Frontiers in Endocrinology (nine articles) and Free Radical Biology and Medicine (highest citation count: 171) emerged as pivotal publication platforms. Mechanistic analyses identified three ferroptosis defense axes (GPX4, FSP1/CoQ10, and GCH1/BH4) and cell type-specific vulnerabilities in tubular, podocyte, and endothelial cells. Preclinical agents, including ginkgolide B (GB) and dapagliflozin, effectively restored iron homeostasis and attenuated oxidative damage.
    Conclusion: Ferroptosis is a promising therapeutic target for DN, yet its clinical translation remains in its infancy. Future efforts should prioritize large-scale clinical trials, single-cell mechanistic profiling, and interdisciplinary integration to bridge molecular insights with precision therapies. This study provides a roadmap for advancing ferroptosis-targeted interventions for DN, emphasizing global collaborations and biomarker-driven strategies.
    Keywords:  GPX4; bibliometric analysis; diabetic nephropathy; ferroptosis; visual analysis
    DOI:  https://doi.org/10.3389/fphys.2025.1516466
  47. Front Immunol. 2025 ;16 1571123
    Bibliometric analysis and knowledge mapping of diabetes mellitus combined with tuberculosis research: trends from 1995 to 2023.
    Yufeng Li, Ruizi Ni, Yajing An, Ling Yang, Zhaoyang Ye, Li Zhuang, Linsheng Li, Liang Wang, Wenping Gong.
       Background: The synergistic epidemic of diabetes mellitus and tuberculosis (DM-TB) has created a dual disease burden, challenging global health systems with complex pathophysiological interactions and suboptimal treatment outcomes. To decode the evolving research landscape, this study presents the latest comprehensive bibliometric analysis mapping the intellectual architecture of DM-TB research over three decades.
    Methods: We systematically analyzed 791 peer-reviewed articles from the Web of Science Core Collection (1995-2023) using CiteSpace, VOSviewer, and Bibliometrix. Advanced metrics including co-citation networks, keyword burst detection, and institutional collaboration patterns were employed to identify paradigm-shifting trends.
    Results: Three distinct growth phases were observed: initial stagnation (1995-2007, <10 annual publications), exponential growth (2008-2019), and research diversification (2020-2023). The United States dominated scientific output (27.3% of total publications), while the London School of Hygiene & Tropical Medicine emerged as the central hub for international collaborations (TLS=176). Keyword evolution revealed three transformative phases: (1) Pathomechanistic exploration (1995-2016): Focused on hyperglycemia-immunity interplay and epidemiological surveillance; (2) Translational innovation (2017-2020): Shifted to preclinical models, pharmacokinetic optimization, and multidrug resistance; (3) Precision medicine era (2021-2023): Emerging hotspots in latent TB screening (burst strength=6.82), metformin-mediated immunomodulation, and AI-driven diagnostic biomarkers.
    Conclusion: Beyond delineating historical trajectories, this study identifies critical knowledge gaps in inflammation-resolution mechanisms and insulin resistance pathways, proposing a roadmap for targeted biomarker discovery and global health policy formulation. The constructed knowledge framework empowers strategic resource allocation for combating the DM-TB syndemic.
    Keywords:  bibliometrics; diabetes mellitus; diabetes mellitus complicated with tuberculosis (DM-TB); research trends; tuberculosis
    DOI:  https://doi.org/10.3389/fimmu.2025.1571123
  48. J Multidiscip Healthc. 2025 ;18 2097-2109
    Bibliometric and Visual Analysis of Alzheimer's Disease and Herpes Simplex Virus Type 1 Infection Between 1990 and 2024.
    Hongling Ren, Ruiyao Song, Hairong Wang, Qingyan Zeng, Yu Fu, Yunchu Guo, Ying Xie, Yusong Ge.
       Background: Recently, some studies suggested that Herpes simplex virus type 1 (HSV-1) infection is an important environmental factor for Alzheimer's disease(AD). The literature on research about HSV-1 infection and AD is emerging. This study used the bibliometric method to investigate the relationship between HSV-1 infection and AD.
    Methods: We searched the Web of Science Core Collection for relevant literature on AD and HSV-1 from 1990 to 2024. Bibliometric and visualization analyses were performed using VOSviewer and CiteSpace.
    Results: From 1990 to 2024, the number of publications showed an increasing trend. The United States made the largest contributions in productivity. The University of Manchester was the most productive organization. Professor Ruth F. Itzhaki was the most influential researcher. The Journal of Alzheimer's Disease had published the most articles. Research on the mechanisms by which HSV infection contributes to AD remains a hotspot in the field, and future studies may further focus on antiviral therapeutic strategies targeting HSV-1 infection.
    Conclusion: Our analysis provides basic information about research in AD and HSV-1. The current research hotspots in this field mainly include the mechanism of AD caused by HSV-1, and antiviral drugs to treat or prevent AD.
    Keywords:  Alzheimer’s disease; Herpes simplex virus type 1; VOSviewer; bibliometric; citespace; visualized analysis
    DOI:  https://doi.org/10.2147/JMDH.S514397
  49. Eur J Orthop Surg Traumatol. 2025 Apr 25. 35(1): 168
    The top 50 most cited articles on minimally invasive Achilles tendon repair: a bibliometric analysis.
    Darcy Ottomanelli, Timothy Blajda, Kevin Posner, Wayne Berberian.
       PURPOSE: Achilles tendon rupture is an increasingly common injury seen in athletic and active populations which can be corrected through strategic operative techniques. The purpose of this study is to identify and review the top 50 most cited articles discussing minimally invasive Achilles tendon repair with regards to the operative technique, outcomes, and complications.
    METHODS: Scopus database was used to search for publications focusing on minimally invasive Achilles tendon repair. The top 50 most cited articles were screened for inclusion criteria and reviewed for year published, journal of publication, country of origin, study type, level of evidence, and citation density.
    RESULTS: The total number of citations from the top 50 most cited articles was 1,415 with a range of five to 168 citations per article. The year of publication ranged from 2004 to 2020, with the majority (n = 33) being published from 2010 to 2020. The most common level of evidence rating was III (25 articles), most of which were cohort studies. The next most common level of evidence rating was IV (11 articles), which were mostly case series. The articles were written across 18 countries, most commonly the United Kingdom (18%), and were published in 28 journals with Foot and Ankle International being the most prolific journal (n = 8).
    CONCLUSION: The results of this study highlighted the prevalence of cohort studies, case series, and technical notes for minimally invasive Achilles tendon repair research. This demonstrates the need for more research with higher level, controlled studies to examine minimally invasive Achilles tendon repair techniques, outcomes, and complications in the future.
    Keywords:  Achilles tendon; Bibliometric; Minimally invasive Achilles tendon repair; Most cited
    DOI:  https://doi.org/10.1007/s00590-025-04289-2
  50. J Multidiscip Healthc. 2025 ;18 2111-2129
    Research Hotspots and Trends in Workplace Violence Among Healthcare Professionals: A Bibliometric and Visualization Analysis Based on Web of Science.
    Qin Lin, Linfeng Liu, Mengxue Fu, Kanlun Chen, Ling Li, Minmin Jiang, Jijun Wu.
       Background: Workplace violence is a significant issue in healthcare settings, affecting the physical and psychological health of healthcare professionals and compromising patient care quality. Despite growing concerns, a comprehensive understanding of the research landscape remains limited.
    Objective: This study aims to analyze the research hotspots and trends in workplace violence among healthcare professionals through bibliometric and visualization analysis, providing insights into the current state of research and identifying future directions.
    Methods: We conducted a comprehensive search of the Web of Science database from inception to August 10, 2024, identifying relevant studies on workplace violence among healthcare professionals. A total of 937 publications were included for analysis. Bibliometric and visualization analysis software (CiteSpace, VOSviewer, BICOMB, and gCLUTO) were used to analyze authors, affiliations, and keywords, and to visualize research trends and hotspots.
    Results: Our analysis revealed 9 distinct clusters of research hotspots, including risk factors, affected departments, demographics, and impacts of workplace violence. Key findings indicate that emergency departments and nursing staff are particularly vulnerable, with significant impacts on mental health and job satisfaction. The study also highlights the increasing trend of publications over the years, reflecting growing research interest in this area.
    Conclusion: The findings reveal that workplace violence is a significant issue affecting the mental and physical health of healthcare professionals, with notable impacts on job satisfaction, patient care quality, and overall organizational climate. Future efforts should focus on strengthening collaborations and developing targeted interventions to mitigate workplace violence, thereby enhancing the safety and quality of healthcare services.
    Keywords:  bibliometric analysis; healthcare professionals; research hotspots; visualization analysis; workplace violence
    DOI:  https://doi.org/10.2147/JMDH.S508935
  51. J Contemp Dent Pract. 2025 Jan 01. 26(1): 110-116
    Trends and Collaborative Networks in the Use of Electrospun Nanofibers in Dentistry: A Bibliometric Study.
    Mabel Huaman-De la Cruz, Julia Medina, Arnaldo Munive-Degregori, Katia Medina-Calderon, Fran Espinoza-Carhuancho, Frank Mayta-Tovalino.
       BACKGROUND: To analyze trends and collaboration networks in the use of electrospun nanofibers in dentistry from 2019 to 2024.
    MATERIALS AND METHODS: A descriptive, observational study with a bibliometric approach was conducted. The inclusion criteria were documents that addressed the use of electrospun nanofibers in dentistry, published between 2019 and 2024. The search was performed in Scopus on December 30, 2024, using a specific keyword strategy. Forty-five relevant documents were identified. The selection, extraction, and analysis procedures were carried out using Bibliometrix, R Studio, and SciVal. Some metrics analysis such as the h-index, number of citations, and collaboration networks were evaluated.
    RESULTS: The results showed an annual decrease of 2.64% in publication growth, with an average of 11.69 citations per document. The University of Michigan, Ann Arbor, and the University of British Columbia stood out for their impact. The most relevant thematic clusters were "tissue scaffolds" and "nanofibers." Most authors had written only one paper. The most influential journals were found in Zone 1 according to Bradford's law.
    CONCLUSION: These findings underline the importance of fostering international collaboration and focusing on high-citation areas to advance the research and application of electrospun nanofibers in dentistry.
    CLINICAL SIGNIFICANCE: This study highlights the clinical importance of electrospun nanofibers in dentistry, showcasing their potential to transform dental treatments. The results stress the need for international collaboration and focusing on high-impact research areas. By analyzing trends and collaborative networks, dental professionals can utilize the advantages of electrospun nanofibers, resulting in improved patient outcomes, enhanced tissue regeneration, and more effective dental therapies. This research paves the way for innovative applications and future advancements in dental materials and techniques. How to cite this article: Huaman-De la Cruz M, Medina J, Munive-Degregori A, et al. Trends and Collaborative Networks in the Use of Electrospun Nanofibers in Dentistry: A Bibliometric Study. J Contemp Dent Pract 2025;26(1):110-116.
    Keywords:  Bibliometrics; Electrospun nanofibers Nanodentistry.
    DOI:  https://doi.org/10.5005/jp-journals-10024-3805
  52. Appl Psychol Health Well Being. 2025 May;17(2): e70033
    The rise of artificial intelligence for cognitive behavioral therapy: A bibliometric overview.
    Loïs Vanhée, Gerhard Andersson, Danilo Garcia, Sverker Sikström.
      Recent years have seen a sharply rising interest in the scientific area dedicated to the study of the use of Artificial Intelligence (AI) for Cognitive Behavioral Therapy (CBT) research and applications (AI4CBT for brevity). Yet, little is known about how this interest is realized and hence the overall status, prospects, and possible challenges of AI4CBT as a field (e.g. breadth of the field, key topics and methods, key producing countries/institutions/authors, interdisciplinary grounding). This paper addresses this gap by developing a broad-spectrum bibliometric analysis towards acquiring a comprehensive overview of the AI4CBT field. Four key dimensions are analyzed (productivity, producers, productions, and contents) along the array of bibliographic metrics, including production trends over time, leading contributors at various levels, co-authorship, citation, and keywords co-occurrence networks, publication formats, key venues, methodological trends, and disciplinary assessment. The paper concludes by framing the status of AI4CBT as a scientific field, allowing to tie it to scientific and applicative challenges and opportunities that AI4CBT may encounter and offer as it further develops.
    Keywords:  Interdisciplinarity analysis; artificial intelligence; bibliometric analysis; cognitive behavioral therapy; topic analysis
    DOI:  https://doi.org/10.1111/aphw.70033
  53. Environ Manage. 2025 Apr 23.
    Uncovering the Science-Policy Interface: Applying Bibliometric Approaches to the Wildfire Risk Management Domain.
    Juliane Schlierkamp, Claudia Berchtold, Isabelle Linde-Frech.
      The impact of research is gaining increasing importance, as science is increasingly seen as a means to address humanity's grand challenges. Consequently, interaction between science and policymakers is essential - a process formalized through Science-Policy Interfaces (SPIs). But who actually participates in these processes? This question is crucial, as scientific findings are not always consistent: they may be subject to interpretation, contradict each other, or be shaped by underlying normative frameworks. This paper explores the potential of bibliometric analysis to trace science-policy interactions, using the Wildfire Risk Management (WFRM) domain as a case study. Drawing on data from the Dimensions database, we examine publication and policy trends, disciplinary coverage, and the influence of Altmetrics on policy citations. Our key findings indicate that: There is a significant time lag (6-9 years) between scientific publication and policy adoption. The number of publications in a research field correlates with policy citations, but not all disciplines are equally represented in policy documents. Altmetrics, particularly social media attention, influence policy uptake, suggesting that visibility beyond academia plays a role in knowledge transfer. Data quality issues in linking scientific research to policy documents persist, limiting full traceability. Despite these limitations, the study highlights the potential of bibliometric approaches to support the development of more transparent and accountable SPIs. With improved data infrastructure, such methods could help policymakers better identify and integrate relevant scientific insights.
    DOI:  https://doi.org/10.1007/s00267-025-02161-x
  54. World Neurosurg. 2025 Apr 18. pii: S1878-8750(25)00345-6. [Epub ahead of print] 123989
    In Reply to the Letter to the Editor Regarding "A Bibliometric Analysis of Sitting Position and Air Embolism in Neurosurgery: Top 100 Most Cited Articles."
    Gökce Hatipoglu Majernik, Mustafa K Baskaya.
      
    DOI:  https://doi.org/10.1016/j.wneu.2025.123989
  55. Med Sci (Basel). 2025 Apr 19. pii: 44. [Epub ahead of print]13(2):
    Intelligent Care: A Scientometric Analysis of Artificial Intelligence in Precision Medicine.
    Khalid M Adam, Elshazali W Ali, Mohamed E Elangeeb, Hytham A Abuagla, Bahaeldin K Elamin, Elsadig M Ahmed, Ali M Edris, Abubakr A Elamin Mohamed Ahmed, Elmoiz I Eltieb.
      The integration of advanced computational methods into precision medicine represents a transformative advancement in healthcare, enabling highly personalized treatment strategies based on individual genetic, environmental, and lifestyle factors. These methodologies have significantly enhanced disease diagnostics, genomic analysis, and drug discovery. However, rapid expansion in this field has resulted in fragmented understandings of its evolution and persistent knowledge gaps. This study employs a scientometric approach to systematically map the research landscape, identify key contributors, and highlight emerging trends in precision medicine. Methods: A scientometric analysis was conducted using data retrieved from the Scopus database, covering publications from 2019 to 2024. Tools such as VOSviewer and R-bibliometrix package (version 4.3.0) were used to perform co-authorship analysis, co-citation mapping, and keyword evolution tracking. The study examined annual publication growth, citation impact, research productivity by country and institution, and thematic clustering to identify core research areas. Results: The analysis identified 4574 relevant publications, collectively amassing 70,474 citations. A rapid growth trajectory was observed, with a 34.3% increase in publications in 2024 alone. The United States, China, and Germany emerged as the top contributors, with Harvard Medical School, the Mayo Clinic, and Sichuan University leading in institutional productivity. Co-citation and keyword analysis revealed three primary research themes: diagnostics and medical imaging, genomic and multi-omics data integration, and personalized treatment strategies. Recent trends indicate a shift toward enhanced clinical decision support systems and precision drug discovery. Conclusions: Advanced computational methods are revolutionizing precision medicine, spurring increased global research collaboration and rapidly evolving methodologies. This study provides a comprehensive knowledge framework, highlighting key developments and future directions. The insights derived can inform policy decisions, funding allocations, and interdisciplinary collaborations, driving further advancements in healthcare solutions.
    Keywords:  artificial intelligence; machine learning; personalized healthcare; precision medicine; scientometric
    DOI:  https://doi.org/10.3390/medsci13020044
  56. Int J Surg. 2025 Apr 18.
    Peripheral nerve blocks for hip fracture surgeries: a bibliometric and visual analysis.
    Chunyang Zhang, Jie Su, Jun Yao, Miao Wang, Cheng Xu, Aizhong Wang.
       BACKGROUND: Hip fractures - encompassing femoral neck and intertrochanteric injuries - are widely recognized as having high morbidity, mortality, and financial burden, particularly among older adults. Despite the growing adoption of peripheral nerve block (PNB) for postoperative pain management, there is a lack of comprehensive bibliometric analyses that elucidate global research trends, collaborations, and advancements in PNB for hip fracture surgeries.
    METHODS: We employed the Web of Science Core Collection to identify 377 English-language original research articles (2004-2024) on PNB in hip fracture procedures. We then utilized VOSviewer and CiteSpace to map publication dynamics, detect prolific contributors, and reveal keyword clusters.
    RESULTS: Our analysis showed that the yearly publication rate rose by 31.81%, with the United States, China, and the United Kingdom leading in output and collaboration. Key techniques included the fascia iliaca, quadratus lumborum, triple nerve, and pericapsular nerve group blocks, each with unique advantages and limitations. The PENG block and adapted fascia iliaca approaches were frequently cited, highlighting their promise for improving analgesia and preserving postoperative mobility. However, high-end ultrasound equipment costs and knowledge gaps in resource-limited settings remain barriers to broader clinical implementation.
    CONCLUSION: These findings indicate a rapid expansion of PNB research in hip fracture care, reflecting its potential to enhance perioperative recovery and reduce complications. Nonetheless, questions persist regarding long-term outcomes, mortality, and cost-effectiveness - particularly in older, high-risk patients. Addressing these challenges through interdisciplinary research, expanded database inclusion, and standardized guidelines could strengthen the role of PNB in hip fracture management worldwide, ultimately improving patient outcomes and advancing the field of perioperative pain control.
    Keywords:  bibliometric analysis; citation analysis; hip arthroplasty; peripheral nerve block; regional anesthesia
    DOI:  https://doi.org/10.1097/JS9.0000000000002407
  57. Front Med (Lausanne). 2025 ;12 1586742
    Biomarkers used in the diagnosis and prognosis of gastric cancer in young patients: a scientometric analysis.
    Nurbek Kozhakhmetuly Azbergenov, Saule Zhumabaevna Akhmetova, Talshyn Amirkhanovna Nurulla, Abdiraman Rsalievich Kaliev, Aigul Bulatovna Ramankulova, Anar Balkashevna Tulyayeva, Nurgul Meirimovna Kereeva.
       Introduction: Gastric cancer in young people is a global health burden, although it is less common than in other age groups. The use of biomarkers is developing in the diagnosis, treatment selection and prognosis of gastric cancer in young patients. In this bibliometric analysis we aim to evaluate the progress of this knowledge, trend topic development and scientific teams and countries involvements in the topic of biomarkers role in gastric cancer in young patients.
    Methods: The data were obtained from Scopus (536 publications) for the period 1993-2024, all relevant metadata were analyzed using RStudio and Biblioshiny package to perform global trends and hotspots analysis.
    Results: Publication trends show a constant increase in interest in gastric cancer biomarkers used in the diagnosis and prognosis of gastric cancer in young patients (7.71% per year). The leading countries were China, USA, and Japan, between which there is strong and sustained collaborations. International co-authorship is relatively low (19.4%). The most prolific research centers were Sungkyunkwan University, Sun Yat-sen University, and Fudan University. The most productive researchers were Zhang X., Wang Y., and Li Y. Keywords analysis showed an increase in mentions of topics related to diagnostics (biomarkers, immunohistochemistry), personalized medicine and prognosis.
    Conclusion: Bibliometric analysis of more than three decades research articles on gastric cancer biomarkers in young patients showed a steady increase, with strong contributions from leading countries and institutions, highlighting the growing focus on diagnostics, personalized medicine, and prognosis.
    Keywords:  adults; biomarkers; immunohistochemistry; stomach cancer; young
    DOI:  https://doi.org/10.3389/fmed.2025.1586742
  58. Laryngoscope Investig Otolaryngol. 2025 Apr;10(2): e70139
    The Association Between Publication Record and Career Path for Facial Plastic and Reconstructive Surgery Fellowship Applicants.
    Khodayar Goshtasbi, Amir A Hakimi, Daniel Kim, Brian J F Wong.
       Introduction: It is unknown whether the publication productivity of facial plastic and reconstructive surgery (FPRS) fellowship applicants before fellowship can be a predictor of pursuing academics in the future. The objective of this study was to assess whether the publication productivity of a cohort of FPRS fellowship applicants was associated with their eventual career path of academic versus non-academic practice.
    Methods: This was a retrospective analysis of a cohort of FPRS fellowship applicants who applied to a single institution from 2012 to 2016. Their submitted publication records at the time of the application process, and their current career positions were queried.
    Results: Thirty-four (27%) of the 125 fellowship applicants are currently in academic positions with no difference in genders (p = 0.66). Academic FPRS clinicians had a significantly higher number of total publications (6.3 ± 5.1 vs. 4.4 ± 3.9, p = 0.03), first author publications (3.4 ± 3.2 vs. 2.1 ± 2.5, p = 0.01), and publications in otolaryngology or plastic/aesthetic surgery journals (4.5 ± 3.9 vs. 3.1 ± 3.3, p = 0.03). There was no difference in the number of plastics, aesthetic, or trauma-specific publications (p = 0.44).
    Conclusion: The number of publications and publications in otolaryngology or plastic/aesthetic surgery journals, but not necessarily articles with specific plastic/aesthetic/trauma topics, may be a predictor of pursuing academia for FPRS fellowship applicants.
    Level of Evidence: 4.
    Keywords:  academic career; facial plastic; fellowship; publication; scholarly
    DOI:  https://doi.org/10.1002/lio2.70139
  59. Proc Biol Sci. 2025 Apr;292(2045): 20250463
    Immediate and longer-term impact of the COVID-19 pandemic on scientific productivity in ecology and evolution.
    Stephanie Meirmans, Erik Postma, Maurine Neiman, Shalene Singh-Shepherd.
      While the subject of much speculation, most quantitative assessments of the effect of the COVID-19 pandemic on scientific productivity (i) are based on self-reported survey data, (ii) cover only a short period of time, (iii) may be biased by an increase in COVID-19-based research, (iv) cover a limited range of publishers or publishing outlets, and/or (v) cannot distinguish between changes in submission versus acceptance rates. Here we analyse submission and acceptance data from 2012 to 2023 for 25 journals in ecology and evolution, a field that has produced relatively few COVID-19-related articles. We show that although submission rates spiked when the pandemic began, they have been plummeting since. While there is variation in these patterns among countries and journals, the latter is unrelated to journal impact factor. The absence of a coinciding change in acceptance rates suggests that journals have not changed their quality standards to buffer these trends in productivity. Together, this demonstrates dynamic but long-term consequences of the COVID-19 pandemic on scientific productivity, suggestive of fundamental changes to scientific practice and communication. A profitable direction for future research would be to build upon our results by targeting topic-, method- and system-related variation in productivity within and across journals.
    Keywords:  acceptance; article; bibliometric; biology; impact factor; interrupted time series; journal; publication; scientific quality; submission
    DOI:  https://doi.org/10.1098/rspb.2025.0463
  60. Clin Nutr. 2025 Apr 17. pii: S0261-5614(25)00108-6. [Epub ahead of print]
    Letter to Editor-Determinants of journal impact factors in Nutrition and Dietetics.
    Chunxiao Dang, Pengfei Liu, Xiao Yu.
      
    Keywords:  Citation metrics; Journal impact factor; Open Access; Scholarly impact evaluation
    DOI:  https://doi.org/10.1016/j.clnu.2025.04.014
  61. Environ Geochem Health. 2025 Apr 22. 47(5): 179
    Ecological risk assessment of emerging contaminants on soil and terrestrial ecosystems (2005-2024): a bibliometric and scientometric review.
    Wen Ma, Qi Wang, Erastus Mak-Mensah, Xiaole Zhao, Wenjia Qi, Jinhui Zhu, Rizwan Azim, Xujiao Zhou, Dengkui Zhang, Bing Liu, Qinglin Liu, Xuchun Li.
      Growing awareness exists regarding the dangers posed by emerging contaminants (ECs) to terrestrial ecosystems and human health. This study reviewed ecological risk assessment studies on ECs, emphasizing their environmental presence, toxicological effects, behavior, and potential negative impacts on soil and terrestrial ecosystems. The work aims to identify key trends, research hotspots, and gaps to provide policy recommendations, inform regulatory frameworks, and suggest future research directions for the sustainable management of ECs in terrestrial environments. A systematic literature review was conducted using the Web of Science database, selecting studies from the past decade related to ECs, soil, terrestrial ecosystems, and ecological risk assessment. A total of 450 documents were analyzed using VOSviewer and CiteSpace to visualize key research patterns. Results indicate a 26.26% annual growth in publications, highlighting increasing scholarly interest. Citation analysis identifies China, the USA, and Italy as leading contributors, with Switzerland exhibiting the highest citation impact per article. Co-authorship network analysis reveals key researchers and collaboration clusters, though cross-group interactions remain limited. Institutional analysis underscores the dominance of the Chinese Academy of Sciences, with notable global partnerships from CSIC (Spain) and King Saud University. Journal analysis highlights Environmental Toxicology and Chemistry and Journal of Environmental Monitoring as highly influential sources. Temporal keyword trends indicate a shift toward ecological risk assessment and contaminant interactions. The study underscores the need for advanced monitoring techniques to manage ECs. Understanding broader ecological impacts, including ecosystem responses and bioaccumulation, is crucial for informed environmental management and policy-making. The findings have significant implications for environmental policy, management strategies, and mitigation measures to protect ecosystem and human health.
    Keywords:  Ecological risk assessment; Emerging contaminants; Environmental monitoring; Microplastics; Soil contamination
    DOI:  https://doi.org/10.1007/s10653-025-02486-w
  62. Ecancermedicalscience. 2025 ;19 1857
    Global trends in the management of cancer through obesity reduction: a bibliometric based systematic literature review.
    Muhammad Hassaan Wali, Hamza Javed, Nisar Ahmad, Ikram A Burney.
       Background: The escalating prevalence of obesity poses increased risk for public health, including an increasing incidence of cancer. The association between obesity and cancer has become an area of increasing concern and investigation. Literature on the treatment of obesity leading to a reduction in the incidence of cancer and as an adjunct to cancer-directed therapy is beginning to emerge. We conducted a bibliometric analysis to study the current trends in published literature.
    Objectives: The aims of the study were to explore the evolving landscape of obesity-related cancer management and identify the current areas of active research in the field.
    Methods: We searched the SCOPUS database on December 11, 2023, to identify the content and patterns of the literature published on the subject of 'treatment of obesity to prevent or treat cancers' using keywords, '(obesity OR overweight OR 'Body Mass Index' OR 'body weight') AND (cancer OR neoplasm) AND (prevention OR 'bariatric surgery' OR 'weight loss' OR 'weight reduction')' in the title, abstract or the author-supplied keywords. After removing non-English and non-journal articles, a manual search was carried out to ensure relevance to the research question. The 'bibliometric package' version R 4.3.2 binaries for macOS 11 (Big Sur) and higher, signed and notarised packages, were used to extract data.
    Results: Over the study period, a total of 724 documents were published, 624 were subjected to manual screening and 95 were identified for analysis. An increase in the number of articles was seen from 2017 onward. 'Bradford's law' was applied, and 5 core journals published 33/95 (34.7%) of all articles and received 1,808/4,399 citations (41.1%). The vast majority of articles, reported on the use of bariatric surgery for weight reduction as a method for cancer prevention and as an adjunct to cancer-directed treatment.
    Conclusion: The treatment of obesity seems to be emerging as a strategy for the prevention and treatment of cancer. The field is relatively new, publications have begun to emerge in the last 10 years, and there is a growing interest in bariatric surgery as a method to prevent obesity-related cancers.
    Keywords:  bariatric surgery; body mass index; body weight; cancer; neoplasm; obesity; overweight; prevention; weight loss; weight reduction
    DOI:  https://doi.org/10.3332/ecancer.2025.1857
  63. Aesthetic Plast Surg. 2025 Apr 21.
    Response to "A Bibliometric Analysis of the Integration of mHealth, Telemedicine, and OpenAI in Aesthetic Plastic Surgery: Advancements, Trends, and Future Directions".
    Bryan Lim, Ishith Seth, Warren M Rozen.
      
    DOI:  https://doi.org/10.1007/s00266-025-04902-z
  64. Front Hum Neurosci. 2025 ;19 1577585
    Artificial intelligence in ADHD: a global perspective on research hotspots, trends and clinical applications.
    Xiaofang Wang, Qianfang Jia, Lvyuan Liang, Weiwei Zhou, Weihua Yang, Jingfeng Mu.
       Background: Artificial Intelligence (AI), has garnered attention in research on attention deficit hyperactivity disorder (ADHD). In the future, AI may have clinical applications in ADHD, particularly in facilitating the objective diagnosis and classification of ADHD. This study aimed to comprehensively analyze the current status and research frontiers of AI applications in ADHD, identifying hotspots and trends to guide future research directions and promote clinical advancements in this field.
    Methods: Articles in the field of AI applications in ADHD were from the Web of Science Core Collection (WoSCC) database. Analysis was conducted using CiteSpace 6.3.R.1. Additionally, high-impact articles were analyzed.
    Results: A total of 342 articles from 50 countries and regions were included. The United States led with 103 articles, having the highest H-index of 21, followed by China with 69 articles, and England with 34 articles. The State University of New York System produced the most articles (11), and Frontiers in Psychiatry had the most articles (12). Burst keywords in 2022-2024 included "diagnosis," "network," "attention deficit hyperactivity disorder" and "artificial intelligence."
    Conclusion: AI technologies have become a prominent topic in ADHD research, with the United States, China, and England leading in articles and influence. The State University of New York System was the most influential institution, while Frontiers in Psychiatry stood out as the key journal. Utilizing networks and other AI technologies for diagnosing ADHD represents current hotspots and future trends, potentially offering objective indicators for ADHD.
    Keywords:  artificial intelligence; attention deficit hyperactivity disorder; diagnosis; hotspot; trend
    DOI:  https://doi.org/10.3389/fnhum.2025.1577585
  65. Laryngoscope. 2025 Apr 25.
    National Institutes of Health Funding and Patent Innovation in Academic Otolaryngology (2014-2024).
    Shiven Sharma, Ronit Sethi, Lawrence Jiang, Prabhjot Singh, Tony Chung, Mohammed Abduljalil, Torin Thielhelm, Alfred Marc Iloreta.
       BACKGROUND: Research productivity, measured through publication and citation indices, is frequently evaluated during the allocation of funding to hospitals, medical departments, or faculty. However, current publication metrics do not sufficiently capture "innovativeness," especially in the realm of health technologies. Patent data, which can serve as markers of tangible innovation, remain underutilized in resource decision-making in otolaryngology.
    STUDY DESIGN: Retrospective study.
    OBJECTIVES: The aim was to explore the relationship between NIH funding and patent production in academic otolaryngology.
    METHODS: The Lens Patent Database (lens.org) was used to obtain patent information for all U.S. A61 patents filed in the past decade, affiliated with otolaryngology faculty at 2023 NIH-funded institutions. Faculty data was algorithmically matched to patents and organized into departmental datasets, which included patent totals, citation statistics, and innovation indices. Departmental attributes were collected from publicly available sources. Univariate and multivariate regression analyses were conducted to identify factors correlated with patent activity.
    RESULTS: Analysis of data from 48 NIH-funded otolaryngology departments revealed an average NIH funding of $3.646 million, with a median of 16.5 patents and 51.5 patent citations per department over the past decade. The amount of NIH funding did not significantly correlate with the 10-year patent count but did show a significant, positive correlation with 10-year patent citations (p < 0.05). The number and proportion of PhD faculty, residency program size, and department rankings were also positively associated with patent output (p < 0.05).
    CONCLUSION: This research underscores the importance of institutional funding, educational background, and residency characteristics in promoting innovation within otolaryngology.
    LEVEL OF EVIDENCE: N/A.
    Keywords:  NIH funding; innovation; otolaryngology; patent; research
    DOI:  https://doi.org/10.1002/lary.32219
  66. Cardiology. 2025 Apr 24. 1-3
    Characterizing the Field of Mendelian Randomization Studies for Cardiovascular Disease.
    Ben Omega Petrazzini.
      
    Keywords:  Bibliometric analysis; Cardiovascular disease; Genetic epidemiology; Mendelian randomization
    DOI:  https://doi.org/10.1159/000545278
  67. Int Wound J. 2025 Apr;22(4): e70670
    RETRACTION: Visualization of the Relationship Between Macrophage and Wound Healing From the Perspective of Bibliometric Analysis.
       RETRACTION: Q. Guo, W. Li, R. Xie, Y. Wang, Y. Xie, K. Cheng, and Z. Sun, "Visualization of the Relationship Between Macrophage and Wound Healing From the Perspective of Bibliometric Analysis," International Wound Journal 21, no. 4 (2024): e14597, https://doi.org/10.1111/iwj.14597. The above article, published online on 20 December 2023, in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the journal Editor in Chief, Professor Keith Harding; and John Wiley & Sons Ltd. Following an investigation by the publisher, all parties have concluded that this article was accepted on the basis of a compromised peer review process. In addition, further investigation by the publisher found that this article is missing the underlying dataset, which contradicts the Data Availability Statement. The investigation found that the Methods and Results included irrelevant citations or otherwise lacked proper citations, which leaves large sections of the statements made unsubstantiated by the academic literature. Lastly, the investigation found that the statistical analysis was incomplete. The editors have therefore decided to retract the article. The authors did not respond to our notice regarding the retraction.
    DOI:  https://doi.org/10.1111/iwj.70670
  68. J Contemp Dent Pract. 2025 Jan 01. 26(1): 86-92
    Scientometric Analysis of Research on Oral and Gut Microbiota and Periodontitis: Collaborative Networks, Emerging Patterns, Thematic Evolution.
    Frank Mayta-Tovalino, Fran Espinoza-Carhuancho, Mabel Huaman-De la Cruz, Antonia Castro Rodríguez, Katia Luz Medina Calderon.
       AIM: To perform a scientometric analysis of scientific literature related to microbiota and periodontitis.
    MATERIALS AND METHODS: A search strategy was applied on 21 July 2024, identifying 1,069 papers from 408 different sources. However, nine articles could not be exported to SciVal due to incomplete metadata. The documents, including 722 articles, 282 reviews, 44 book chapters, among others, showed an annual growth rate of 7.53%. Bibliometrix and SciVal were used for data extraction and analysis.
    RESULTS: A total of 1,069 papers from 408 different sources, published between 2019 and 2024, were identified. The most frequent terms in the research were "periodontitis", "oral microbiome", "microbiome", "periodontal disease", and "dysbiosis". According to Lotka's Law, most authors in the field contributed a small number of papers. The most cited journals in this field were "Frontiers in Cellular and Infection Microbiology", "Journal of Oral Microbiology", and "Periodontology 2000". Analysis of the thematic evolution shows an increasing intersection of topics in recent research, reflecting the multifaceted nature of periodontitis and its interaction with a variety of other health factors.
    CONCLUSION: Research on periodontitis and microbiota is multifaceted, interacts with a variety of health factors, and shows a growing intersection of topics in recent research.
    CLINICAL SIGNIFICANCE: This study presents a detailed review of the literature on gut microbiota and periodontitis, notes on current developments, and gives hints regarding still emerging themes. Its findings may serve to continue with future guidelines or research and to understand the relationship of gut microbiota with periodontitis. How to cite this article: Mayta-Tovalino F, Espinoza-Carhuancho F, Huaman-De la Cruz M, et al. Scientometric Analysis of Research on Oral and Gut Microbiota and Periodontitis: Collaborative Networks, Emerging Patterns, Thematic Evolution. J Contemp Dent Pract 2025;26(1):86-92.
    Keywords:  Microbiota; Periodontitis Scientometrics.
    DOI:  https://doi.org/10.5005/jp-journals-10024-3814
  69. Clin Nutr. 2025 Apr 12. pii: S0261-5614(25)00106-2. [Epub ahead of print]
    Reply to Letter to the Editor: Determinants of journal impact factors in Nutrition and Dietetics.
    Dileep N Lobo, Keith R Neal.
      
    Keywords:  Bibliometrics; Clarivate™; Determinants; Journal citation Reports™; Journal impact factor; Nutrition and Dietetics
    DOI:  https://doi.org/10.1016/j.clnu.2025.04.012
  70. Front Med (Lausanne). 2025 ;12 1523902
    Opportunities and challenges with artificial intelligence in allergy and immunology: a bibliometric study.
    Ningkun Xiao, Xinlin Huang, Yujun Wu, Baoheng Li, Wanli Zang, Khyber Shinwari, Irina A Tuzankina, Valery A Chereshnev, Guojun Liu.
       Introduction: The fields of allergy and immunology are increasingly recognizing the transformative potential of artificial intelligence (AI). Its adoption is reshaping research directions, clinical practices, and healthcare systems. However, a systematic overview identifying current statuses, emerging trends, and future research hotspots is lacking.
    Methods: This study applied bibliometric analysis methods to systematically evaluate the global research landscape of AI applications in allergy and immunology. Data from 3,883 articles published by 21,552 authors across 1,247 journals were collected and analyzed to identify leading contributors, prevalent research themes, and collaboration patterns.
    Results: Analysis revealed that the USA and China are currently leading in research output and scientific impact in this domain. AI methodologies, especially machine learning (ML) and deep learning (DL), are predominantly applied in drug discovery and development, disease classification and prediction, immune response modeling, clinical decision support, diagnostics, healthcare system digitalization, and medical education. Emerging trends indicate significant movement toward personalized medical systems integration.
    Discussion: The findings demonstrate the dynamic evolution of AI in allergy and immunology, highlighting the broadening scope from basic diagnostics to comprehensive personalized healthcare systems. Despite advancements, critical challenges persist, including technological limitations, ethical concerns, and regulatory frameworks that could potentially hinder further implementation and integration.
    Conclusion: AI holds considerable promise for advancing allergy and immunology globally by enhancing healthcare precision, efficiency, and accessibility. Addressing existing technological, ethical, and regulatory challenges will be crucial to fully realizing its potential, ultimately improving global health outcomes and patient well-being.
    Keywords:  allergy and immunology; artificial intelligence; bibliometric study; deep learning; health management; immunology; machine learning
    DOI:  https://doi.org/10.3389/fmed.2025.1523902
  71. JMIR Res Protoc. 2025 Apr 22. 14 e58567
    Patient-Related Metadata Reported in Sequencing Studies of SARS-CoV-2: Protocol for a Scoping Review and Bibliometric Analysis.
    Karen O'Connor, Davy Weissenbacher, Amir Elyaderani, Ebbing Lautenbach, Matthew Scotch, Graciela Gonzalez-Hernandez.
       BACKGROUND: There has been an unprecedented effort to sequence the SARS-CoV-2 virus and examine its molecular evolution. This has been facilitated by the availability of publicly accessible databases, such as the GISAID (Global Initiative on Sharing All Influenza Data) and GenBank, which collectively hold millions of SARS-CoV-2 sequence records. Genomic epidemiology, however, seeks to go beyond phylogenetic (the study of evolutionary relationships among biological entities) analysis by linking genetic information to patient characteristics and disease outcomes, enabling a comprehensive understanding of transmission dynamics and disease impact. While these repositories include fields reflecting patient-related metadata for a given sequence, the inclusion of these demographic and clinical details is scarce. The current understanding of patient-related metadata in published sequencing studies and its quality remains unexplored.
    OBJECTIVE: Our review aims to quantitatively assess the extent and quality of patient-reported metadata in papers reporting original whole genome sequencing of the SARS-CoV-2 virus and analyze publication patterns using bibliometric analysis. Finally, we will evaluate the efficacy and reliability of a machine learning classifier in accurately identifying relevant papers for inclusion in the scoping review.
    METHODS: The National Institutes of Health's LitCovid collection will be used for the automated classification of papers reporting having deposited SARS-CoV-2 sequences in public repositories, while an independent search will be conducted in MEDLINE and PubMed Central for validation. Data extraction will be conducted using Covidence (Veritas Health Innovation Ltd). The extracted data will be synthesized and summarized to quantify the availability of patient metadata in the published literature of SARS-CoV-2 sequencing studies. For the bibliometric analysis, relevant data points, such as author affiliations, citation metrics, author keywords, and Medical Subject Headings terms will be extracted.
    RESULTS: This study is expected to be completed in early 2025. Our classification model has been developed and we have classified publications in LitCovid published through February 2023. As of September 2024, papers through August 2024 are being prepared for processing. Screening is underway for validated papers from the classifier. Direct literature searches and screening of the results began in October 2024. We will summarize and narratively describe our findings using tables, graphs, and charts where applicable.
    CONCLUSIONS: This scoping review will report findings on the extent and types of patient-related metadata reported in genomic viral sequencing studies of SARS-CoV-2, identify gaps in the reporting of patient metadata, and make recommendations for improving the quality and consistency of reporting in this area. The bibliometric analysis will uncover trends and patterns in the reporting of patient-related metadata, including differences in reporting based on study types or geographic regions. The insights gained from this study may help improve the quality and consistency of reporting patient metadata, enhancing the utility of sequence metadata and facilitating future research on infectious diseases.
    TRIAL REGISTRATION: OSF Registries osf.io/wrh95; https://doi.org/10.17605/OSF.IO/WRH95.
    INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/58567.
    Keywords:  COVID-19; GISAID; GenBank; SARS-CoV-2; genomic epidemiology; patient-related metadata; protocol; scoping review; sequence records
    DOI:  https://doi.org/10.2196/58567
  72. J Formos Med Assoc. 2025 Apr 23. pii: S0929-6646(25)00180-9. [Epub ahead of print]
    Response to the letter: Comment on 'A bibliometric analysis of primary health care publication trends in the Asia-Pacific region from 2011 to 2023'.
    Chun-Feng Huang, Shinn-Jang Hwang.
      
    DOI:  https://doi.org/10.1016/j.jfma.2025.04.011
  73. Front Genome Ed. 2025 ;7 1558432
    Mapping the therapeutic landscape of CRISPR-Cas9 for combating age-related diseases.
    Qiyu He, Yida Wang, Zhimin Tan, Xian Zhang, Chao Yu, Xiaoqin Jiang.
      CRISPR-Cas9 (clustered regularly interspaced short palindromic repeats-associated protein 9) has emerged as a transformative genome-editing tool with significant therapeutic potential for age-related diseases, including Alzheimer's disease, Parkinson's disease, cardiovascular disorders, and osteoporosis. This study presents a bibliometric analysis of CRISPR-Cas9 research in age-related diseases, identifying key contributors, major research hotspots, and critical technological advancements. While promising applications have been demonstrated in gene repair, functional regulation, and molecular interventions, significant barriers persist, including off-target effects, low delivery efficiency, and limited editing in non-dividing cells. Ethical concerns over germline editing and gaps in long-term safety data further complicate clinical translation. Future directions emphasize the development of high-precision Cas9 variants, homology-directed repair-independent tools, and efficient delivery systems, alongside the establishment of international regulatory frameworks and multicenter clinical trials. These efforts are essential to fully realize the potential of CRISPR-Cas9 in addressing the global health challenges of aging.
    Keywords:  CRISPR-Cas9; age-related diseases; bibliometric analysis; gene therapy; genome editing
    DOI:  https://doi.org/10.3389/fgeed.2025.1558432
  74. World Neurosurg. 2025 Apr 17. pii: S1878-8750(25)00352-3. [Epub ahead of print] 123996
    The Evolvement of the 100 Most Cited Articles in Spine Surgery In the Last Decade Compared to All-Time.
    Mark Miller, Matthew Meade, Ruchir Nanavati, William T DiCiurcio, Maneesha Palakurthi, Adam Kohring, Justin Le, Christopher Giuditta, Christopher Kepler, Barrett Woods.
       BACKGROUND CONTEXTS: Decision-making in spine surgery is continuously shaped by advancements in the field through evidence-based medicine. This is demonstrated through the evolution of the quality and impact of scientific research within the field of spine surgery. To date, there is limited literature investigating interval changes in methodological rigor of scientific investigation within the field of spine surgery.
    METHODS: The top 100 cited articles were recorded for manuscripts from January 1, 2013, to December 31, 2023, and the top 100 most cited manuscripts of all time for spine surgery, via the Scopus abstract and citation database. Data collected included year of publication, article type, LOE, MINORs/(Physiotherapy Evidence Database(PEDro) Scale.
    RESULTS: Most studies for all-time cohort (33.8%) were reported as level IV and over the last decade (41.1%) were level III. The average MINOR scores for comparative studies was 18.1 for the all-time cohort and 15.7 for the decade cohort (P<0.05). The average MINORs scores for noncomparative studies were 9.7 for the all-time cohort and 8.98 for the decade cohort (P=0.278). The average PEDro score was 0.72 for the all-time cohort and 0.61 for the decade cohort (P>0.05). The number of level IV studies decreased from 33.8% in the all-time cohort to 12.3% in the last decade with increases in level II studies from 0% all-time to 6.85% in the last decade (P<0.05).
    CONCLUSION: An overall increase in the level of evidence over time within the field of spine surgery was demonstrated with an associated decreased methodologic rigor within recent non-randomized investigations. A focus on enhancing the quality of investigation is prudent to guide evidence-based practice in spine surgery.
    Keywords:  Most-cited; level of evidence; spine surgery; study metrics
    DOI:  https://doi.org/10.1016/j.wneu.2025.123996
  75. Fam Med. 2025 Apr;57(4): 286-291
    Gender Parity in CERA Survey Submissions.
    Katherine M Wright, Heather L Paladine, Miranda A Moore, Grace Shih, Santina J G Wheat.
       BACKGROUND AND OBJECTIVES: The Council of Academic Family Medicine Educational Research Alliance (CERA) is a unique collaboration of academic family medicine organizations (Society of Teachers of Family Medicine [STFM], Association of Family Medicine Residency Directors, North American Primary Care Research Group, Association of Departments of Family Medicine) that facilitates and improves educational research in family medicine. CERA conducts approximately five surveys per year, including residency program directors, clerkship directors, department chairs, and general membership. Members of these organizations propose modules of 10 questions for these surveys. Proposals are peer-reviewed, and the top proposals are incorporated, along with standardized demographic questions, into an omnibus survey. We sought to determine the impact of self-reported gender of the primary submitter on survey module acceptance rates.
    METHODS: We conducted a bibliometric analysis to explore author characteristics and quantify dissemination efforts. We conducted ꭓ2 analyses to determine gender differences in proposal acceptance. We used the exact binomial test to compare proportions of women authors to the benchmark proportion of women in STFM.
    RESULTS: Overall, women submitted 66% (460/699) of CERA survey module proposals and authored 65% of accepted CERA modules (157/241) with the highest proportion concentrated among Clerkship Surveys (73%, 40/55). The acceptance rate did not differ significantly by gender (χ2=0.07, df=1, P=.80). A total of 73.4% (177/241) of module authors went on to present or publish their findings; we found no significant differences in scholarly output by gender (χ2=0.70, df=1, P=.41).
    CONCLUSIONS: These findings indicate that the CERA module submission process has been successful in achieving comparable acceptance rates for men and women submitters. Other specialties should consider a similar model as a means to support early career educational researchers, including women.
    DOI:  https://doi.org/10.22454/FamMed.2025.925429
  76. J Environ Manage. 2025 Apr 21. pii: S0301-4797(25)01378-7. [Epub ahead of print]383 125402
    Global trends and prospects in research on heavy metal pollution at contaminated sites.
    Jia'ao Yu, Zhen Chen, Wenhao Gao, Shuang He, Dan Xiao, Wei Fan, Mingxin Huo, Wahyunanto Agung Nugroho.
      Soil contamination by heavy metals is a global environmental challenge, poses a serious risk to plant life, human health, and global food supply. In recent years, advanced and effective remediation strategies for heavy metal-contaminated soils have developed rapidly, and a systematic summarization of this progress is important. Based on 2822 bibliographic data (2014-2023) acquired from the Web of Science Core Collection, the research status, hotspots and trends of heavy metal-contaminated sites worldwide had been synthetically analyzed in scientometrics. The results showed that China, India, and the USA were the most active countries in related research, and the main research subjects were the assessment of contaminated sites and remediation methods. The keywords showed 3 co-occurrence clusters, focusing on site characterization, phytoremediation and physical-chemical remediation. The time zone view shows a multidisciplinary amalgamation tendency particular in methods such as using artificial intelligence and remote sensing to predict spatial distribution and migration characteristics of heavy metals. Regarding the types of contaminated sites, the most frequently studied are mining sites and industrial waste sites. Among heavy metals, Cd, Pb, and Zn are the most commonly studied pollutants. The heavy metal contamination in soil, ranked by the geo-accumulation index, is as follows: Cd (5.91) > Pb (4.12) > Zn (3.73) > Cu (2.37) > Cr (1.85) > Ni (1.34). In terms of remediation technologies, the frequency of utilization is ranked as follows: phytoremediation > microbial remediation > soil washing > electrokinetic remediation > oxidation reduction > solidification/stabilization > thermal desorption > soil replacement. Additionally, phytoremediation and soil washing are the most effective technologies for removing Cd, Pb, and Zn. The insights derived from this study contribute to a deeper understanding of the state-of-the-art in this field and help to develop/select applicable methods for the effective remediation of heavy metal-contaminated sites.
    Keywords:  Bibliometric analysis; Contaminated site; Heavy metal pollution; Pollution assessment
    DOI:  https://doi.org/10.1016/j.jenvman.2025.125402
  77. Front Res Metr Anal. 2025 ;10 1603155
    Erratum: Bibliometrics effects of a new paper level classification.
    Frontiers Production Office
      [This corrects the article DOI: 10.3389/frma.2025.1531758.].
    Keywords:  ASJC; Scopus; classification systems; item-by-item classification; scientometrics
    DOI:  https://doi.org/10.3389/frma.2025.1603155
  78. Laryngoscope. 2025 Apr 25.
    An Evaluation of Current Trends in AI-Generated Text in Otolaryngology Publications.
    Rachel B Kutler, Sean A Setzen, Samantha Tsai, Anaïs Rameau.
       OBJECTIVES: Since the release of ChatGPT-4 in March 2023, large language models (LLMs) application in biomedical manuscript production has been widespread. GPT-modified text detectors, such as GPTzero, lack sensitivity and reliability and do not quantify the amount of AI-generated text. However, recent work has identified certain adjectives more frequently used by LLMs that can help identify and quantify LLM-modified text. The aim of this study is to utilize these adjectives to identify LLM-generated text in otolaryngology publications.
    STUDY DESIGN: Meta-research.
    METHODS: Twenty-five otolaryngology journals were studied between November 2022 and July 2024, encompassing 8751 published works. Articles from countries where ChatGPT-4 is not available were removed, yielding 7702 articles for study inclusion. These publications were analyzed using a Python script to determine the frequency of the top 100 adjectives disproportionately generated by ChatGPT-4.
    RESULTS: A significant increase in the frequency of adjectives associated with GPT use was observed from November 2023 to July 2024 across all journals (p < 0.001), with a significant difference before and after the release of ChatGPT in March 2023. Journals with higher impact factors had significantly lower usage of GPT-associated adjectives than those with lower impact factors (p < 0.001). There was no significant difference in GPT-associated adjective use by first authors with a doctoral degree versus those without. Publications by authors from English-speaking countries demonstrated a significantly more frequent use of LLM-associated adjectives (p < 0.001).
    CONCLUSIONS: This study suggests that ChatGPT use in otolaryngology manuscript production has significantly increased since the release of ChatGPT-4. Future research should be aimed at further characterizing the landscape of AI-generated text in otolaryngology and developing tools that encourage authors' transparency regarding the use of LLMs.
    LEVEL OF EVIDENCE: NA.
    Keywords:  artificial intelligence; large language models; otolaryngology
    DOI:  https://doi.org/10.1002/lary.32202
  79. Curr Pharm Des. 2025 Apr 21.
    Exploring the Multifaceted Metabolic Pathology and Mechanisms of NAFLD: A Bibliometric Analysis and an In-depth Review.
    Xinyi Jiao, Haitao Wang, Rongrong Li, Tekleab Teka, Zhifei Fu, Haiyang Yu, Jie Li, Rui Su, Lifeng Han.
      Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome, affecting about a quarter of the world's population. As the prevalence of obesity and metabolic syndrome rises, NAFLD is projected to become the leading cause of cirrhosis in the coming years. NAFLD is a complex disease whose pathophysiology mainly focuses on metabolic dysfunction and intestinal microecological dysregulation. Shifts between free fatty acid (FFA) metabolism and cell damage could be of major interest in finding new therapeutic targets. However, current public understanding of these diseases remains limited. Based on bibliometrics and extensive studies, this study explored the mechanisms by which FFAs regulate the occurrence of NAFLD. This review not only focuses on the role of the vicious cycle derived from FFA metabolic disorders, ecological disorders, and liver damage immunity concerning diabetes mellitus type 2 and NAFLD but also discusses the mechanisms involved in them.
    Keywords:  Free fatty acids; bibliometric analysis; gut microbiota; immune system; metabolism; non-alcoholic fatty liver disease.
    DOI:  https://doi.org/10.2174/0113816128350055250224055446
  80. Neurosurgery. 2025 Apr 21.
    Costs of Academic Engagement in Organized Neurosurgery in the United States.
    Michael M Covell, Stefan T Prvulovic, Immaculate Christie, Joanna M Roy, Javed Iqbal, Aryan Gajjar, Bhavya Pahwa, Charles Bowers, Cameron J Sabet, Marc D Moisi, Johnny Delashaw, Meic Schmidt, Christian A Bowers.
       BACKGROUND AND OBJECTIVES: Organized neurosurgery offers innumerable opportunities for scientific exchange, networking, and continuing medical education (CME). National, regional, and state societies and meetings have rapidly proliferated across neurosurgery, as have neurosurgical-associated publications and journals. This study sought to review individual costs incurred by neurosurgeons seeking engagement in organized neurosurgery to illustrate the costs associated with participation.
    METHODS: National, regional, and state neurosurgery societies were identified, and associated annual meetings were recorded. Leading neurosurgery journals, as determined by reputation and impact factor, were selected. Data unavailable online were acquired through direct communication with the respective organization. American Board of Neurological Surgeons board-certification costs were acquired and compared with board-certification costs in comparable specialties (orthopedic surgery (Ortho), plastic surgery (PS), general surgery (GS), neurology). Baseline academic engagement was defined as two general society memberships, two annual meeting registrations, and respective board certification. A CME credit-per-dollar value was created to measure the relative financial value of CME.
    RESULTS: A total of 31 societies, 23 meetings, and 18 journals were identified. Society membership costs included American Association of Neurological Surgeons ($1100), Congress of Neurological Surgeons ($990), Society of NeuroInterventional Surgery ($775), and Cervical Spine Research Society ($950). Meetings with the greatest registration fees included the Society of Neurological Surgeons ($1800) and the American Society of Pediatric Neurosurgeons ($1675) annual meetings. Individual journal subscription costs included Journal of Neurosurgery ($636), Neurosurgery ($643), Spine ($1188), and World Neurosurgery ($909). In our limited comparison, the specialty of neurosurgery had the greatest baseline academic engagement cost ($11,588; PS: $8105; Ortho: $7013; GS: $5570; neurology: $4640). Costs of nontraditional CME are significantly less compared with traditional, meeting-driven CME opportunities.
    CONCLUSION: Organized neurosurgery incurs major individual costs by way of society membership, meeting registration, and journal subscriptions. Rising costs for engagement are substantial and may not be sustainable when contrasted with unchanged CME reimbursement, prompting dialog to identify sources of subsidization.
    Keywords:  Academic neurosurgery; Conference; Costs; Organized neurosurgery; Society
    DOI:  https://doi.org/10.1227/neu.0000000000003452
  81. Nature. 2025 Apr;640(8060): S65
    China overtakes the United States in cancer research output.
      
    Keywords:  Cancer; Medical research; Publishing
    DOI:  https://doi.org/10.1038/d41586-025-01154-4
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