bims-evares Biomed News
on Evaluation of research
Issue of 2025–03–09
85 papers selected by
Thomas Krichel, Open Library Society
  1. Research hotspots and trends of plumbagin: A bibliometric perspective.
  2. Journals with "pain" in their titles: A web of science-based bibliometric analysis.
  3. Global Research Trends in Endoscopic and External Dacryocystorhinostomy: A Bibliometric Analysis.
  4. Female authorship in global research: a bibliometric study of high- and low-income country collaborations.
  5. The power of role play in nursing education: A bibliometric analysis and visualization.
  6. A Bibliometric and Visual Analysis of Oliceridine Research (2013-2024).
  7. Evaluating Growth in Dry Socket Publications: A Bibliometric Analysis.
  8. Application of artificial intelligence in Alzheimer's disease: a bibliometric analysis.
  9. Research trends of inflammation in autism spectrum disorders: a bibliometric analysis.
  10. Global research on NK cells in miscarriage: a bibliometric study.
  11. Bibliometric analysis of preoperative radiotherapy for locally advanced rectal cancer: evolution and future.
  12. Research trends and hot spots in obesity-induced pain: A bibliometric analysis of the last 20 years.
  13. Global research dynamics in urea cycle disorders: a bibliometric study highlighting key players and future directions.
  14. The Top 100 Most Cited Articles on Anterolateral Ligament: A Bibliometric Analysis and Review.
  15. Trends in Research on Hypertrophic Cardiomyopathy and Mitochondria From 2003 to 2023: A Bibliometric Analysis.
  16. A Bibliometric Review of the Top 100 Most Cited Articles in Hip Preservation, Not Counting Self-Citations.
  17. Global Trends in Neurosurgical Research: Insights from the Top 100 Most-Cited Articles.
  18. Research hotspots and trends of the SLC26A4 gene-related hearing loss from the perspective of knowledge graph.
  19. Research hotspots and development trends of Brucellar spondylitis in the past 30 years: a bibliometric analysis.
  20. Research trends and hotspots of Colles fracture: a bibliometric analysis from 1980 to 2023.
  21. Research trends and hotspots in the surgical treatment of peripheral nerve injuries of the upper limb from 2000 to 2024: a bibliometric visualization study.
  22. Global landscape of hepatic organoid research: A bibliometric and visual study.
  23. The application of artificial intelligence in stroke research: A bibliometric analysis.
  24. Bibliometric analysis of OCD prevalence in youth populations of developing countries.
  25. Global trends and emerging research in nanotechnology for esophageal cancer: a comprehensive bibliometric analysis.
  26. Bibliometric analysis of the Top 1000 most-cited articles in otolaryngology over the past decade: global research trends and hotspots.
  27. Harmful oral habits in childhood: a global bibliometric analysis.
  28. Artificial intelligence and perinatology: a study on accelerated academic production- a bibliometric analysis.
  29. Immunological landscape of hepatic alveolar echinococcosis: A bibliometric analysis.
  30. Global research prospects and trends in TFH cells and tumors: a bibliometric analysis.
  31. A bibliometric analysis of primary health care publication trends in the Asia-Pacific region from 2011 to 2023.
  32. Exploring Research Trends and Mechanisms: Maternal Diabetes and Neural Tube Defects (1991-2023).
  33. Global research trends in liquid biopsy for ovarian cancer from 1999 to 2023: A 25-year bibliometric analysis.
  34. Visual analysis of emerging topics and trends in contrast agent extravasation research in medical imaging: a bibliometric study using CiteSpace and VOSviewer.
  35. Comments on "worldwide research trends on tumor burden and immunotherapy: a bibliometric analysis".
  36. Quantitative analysis of literature on diagnostic biomarkers of Schizophrenia: revealing research hotspots and future prospects.
  37. Tandem mass spectrometry in screening for inborn errors of metabolism: comprehensive bibliometric analysis.
  38. Examining gender trends in PA authorship: A retrospective analysis of JAAPA and JPAE.
  39. Trends and Insights in Cognitive Impairment and Depression Research: A Comprehensive Bibliometric Analysis.
  40. Bibliometric analysis of global research on dialectical behavior therapy from 1987 to 2024.
  41. Prognostic factors and outcomes in pediatric acute myeloid leukemia: a comprehensive bibliometric analysis of global research trends.
  42. Laryngeal Dystonia: A Global Retrospective Study Through Bibliometric Analysis.
  43. A bibliometric analysis of a decade's research on metabolic dysfunction-associated steatotic liver disease in the Arab world.
  44. The application of artificial intelligence in insomnia, anxiety, and depression: A bibliometric analysis.
  45. Analysis of research status and trends on nano-agricultural application: a bibliometric study.
  46. Global research landscape and trends in Toxoplasma gondii from 2003 to 2022: A bibliometric analysis.
  47. Phosphate-solubilizing microorganisms for soil health and ecosystem sustainability: a forty-year scientometric analysis (1984-2024).
  48. The trend of publications in the Journal of Conservative Dentistry and Endodontics: A 6-year systematic survey of the journal.
  49. Global trends and research hotspots in nanodrug delivery systems for breast cancer therapy: a bibliometric analysis (2013-2023).
  50. Analysis of global trends and hotspots of skin microbiome in acne: a bibliometric perspective.
  51. A bibliometric analysis of studies on artificial intelligence in neuroscience.
  52. A systematic analysis of temporal trends, characteristics, and citations of retracted stem cell publications.
  53. Bibliometric and Bioinformatics Analysis of Renal Impairment in Multiple Myeloma: Trends and Research Hotspots, and Associated Genetic Pathways (2000-2023).
  54. A review on multi-objective optimization of building performance - Insights from bibliometric analysis.
  55. Worldwide research trends of pregnancy hypertension in epigenetics field.
  56. Emerging insights into thyroid cancer from immunotherapy perspective: A correspondence.
  57. Bibliometric analysis of global research on the clinical applications of aminoglycoside antibiotics: improving efficacy and decreasing risk.
  58. Rare disease publishing trends worldwide and in China: A CiteSpace-based bibliometric study.
  59. Imaging genomics of cancer: a bibliometric analysis and review.
  60. Comprehensive Analysis of the Biomechanical Research of Pelvic Organ Prolapse: A Scientometric Approach.
  61. Liver function linked to bone health: A bibliometric of the liver-bone axis.
  62. Scientific landscape and visualization analysis of the link between adenomyosis and infertility from 2000 to 2024.
  63. Librarian involvement on knowledge synthesis articles and its relationship to article citation count and Journal Impact Factor.
  64. Assessing the quality of studies funded by the Israel National Institute for Health Policy Research, 2010-2020.
  65. A bibliometric and visualization analysis of the role of traditional Chinese medicine in cancer immunotherapy.
  66. Effect of music intervention on dental anxiety and fear: A bibliometric analysis of RCTs from 2004 to 2024.
  67. A bibliometric analysis of perioperative medicine and artificial intelligence.
  68. Global landscape of liquid biopsy research: Regional contributions and disparities.
  69. Changes in urologic research from a new perspective: Text mining analysis of publication topics.
  70. The fate of manuscripts rejected by the Turkish Journal of Physical Medicine and Rehabilitation.
  71. A bibliometric study of rare diseases in English and Chinese databases from 1985 to 2024 based on CiteSpace.
  72. Use of Artificial Intelligence, Internet of Things, and Edge Intelligence in Long-Term Care for Older People: Comprehensive Analysis Through Bibliometric, Google Trends, and Content Analysis.
  73. Editors' Selections from Relevant Scientific Publications.
  74. Application of large language models in healthcare: A bibliometric analysis.
  75. Comparing academic productivity and Instagram presence in oral and maxillofacial surgery training programs.
  76. Towards eco-friendly pharmaceuticals: Regulatory and policy approaches for sustainable medicines use.
  77. The research focus of academicians in analyzing women entrepreneurship intentions: A 40-year scientometric review with thematic analysis and NGT.
  78. Citation penalties following sexual versus scientific misconduct allegations.
  79. Multifaceted Role of Probiotics in Enhancing Health and Growth of Aquatic Animals: Mechanisms, Benefits, and Applications in Sustainable Aquaculture-A Review and Bibliometric Analysis.
  80. Global systematic mapping of Vibrio species pathogenicity: A PRISMA-guided cluster-based analysis.
  81. Using network analysis and large-language models to obtain a landscape of the literature on dressing materials for wound healing: The predominance of chitosan and other biomacromolecules: A review.
  82. Significance, applications, and contributions of Gamma Knife radiosurgery in advancing neurosurgical care in lower-middle-income countries: a systematic review.
  83. Web references are not eternal: time-trend and qualitative impact of the loss of access to online resources cited in peer-reviewed medical journals.
  84. Increasing Research Productivity and Step 2 Score Among Matched Orthopaedic Surgery Residents: A Forecasting Analysis to 2040.
  85. Effect of Citation Numbers and Team Members on the Possibility of and Time Needed to Complete Screening for Systematic and Scoping Reviews.
  1. Medicine (Baltimore). 2025 Feb 28. 104(9): e41726
    Research hotspots and trends of plumbagin: A bibliometric perspective.
    Zichen Xu, Yuqi Xin, Xinjian Zhang, Jianwei Liu, Yang Liu, Runying Guo, Qingkun Jiang, Jiaxuan Qiu.
      Plumbagin is a biologically active naphthoquinone compound. Research related to plumbagin has gained popularity, evidenced by a gradual increase in publications. However, a bibliometric study in this field has yet to be conducted. Consequently, this study aims to evaluate the global scientific output of plumbagin research through bibliometric analysis, explore the status of research in this field over the past 15 years, and predict its future research hotspots. Visual analysis software, including CiteSpace, VOSviewer, and the R package 'bibliometrix', was employed to analyze all literature pertaining to plumbagin published between 2009 and 2024. Bibliometric records were sourced from the Web of Science Core Collection. This study analyzed a total of 2061 publications. China was found to have the largest number of publications, while the Council of Scientific & Industrial Research recorded the highest publication count in this field. Thomas and David D were identified as the authors with the most publications. The journal with the highest number of citations was J Biol Chem, and Padhye S was noted as the author with the highest citation count. In recent years, cancer treatment has emerged as the most closely related research topic concerning plumbagin, and keyword cluster analysis highlighted 'sarcoplasmic reticulum' as a prominent research keyword. Through quantitative and visual analysis of plumbagin, this study reveals that plumbagin research remains a valuable field. Anticancer treatment of plumbagin is identified as a future research direction.
    DOI:  https://doi.org/10.1097/MD.0000000000041726
  2. Medicine (Baltimore). 2025 Feb 28. 104(9): e41732
    Journals with "pain" in their titles: A web of science-based bibliometric analysis.
    Shao-Yu Chi, Wei-Ting Wu, Ke-Vin Chang, Levent Özçakar.
       BACKGROUND: Pain, a critical symptom prevalent in various diseases and syndromes, has garnered increased attention in recent scientific literature. Bibliometric analyses can offer valuable multi-disciplinary insights into pain. This bibliometric analysis focused on journals with "pain" in their titles.
    METHODS: Using the Master Journal List in the Web of Science (WoS) database (up to December 31, 2024), we searched all the journals indexed in Science Citation Index Expanded (SCIE) or Social Sciences Citation Index (SSCI) with "pain" in their titles. For further analyses, we extracted data about the journals including publisher, country, language, frequency, SCIE/SSCI categories, journal impact factor, and citation.
    RESULTS: We identified 19 journals with "pain" in their titles. All the included journals were indexed in SCIE, with Pain Management Nursing also indexed in SSCI. More than half of the journals were published in the United States of America or the United Kingdom, and all were in English. Regarding the SCIE categories, 13 journals were listed in "clinical neurology," 8 in "anesthesiology," and 5 in "neurosciences." From 2018 to 2022, either Pain or Journal of Headache and Pain maintained the highest impact factor. Furthermore, Pain held the record for the most citable articles and reviews and the most total citations in 2022.
    CONCLUSION: This study is the first bibliometric analysis of journals, rather than articles, in the field of pain. Pain is the most recognized journal in the field, with the highest number of citations and the highest average impact factor. In the future, bibliometric studies should explore other relevant journals without the word "pain" in their titles, in order to gain a more comprehensive understanding of the scientific literature on pain studies.
    DOI:  https://doi.org/10.1097/MD.0000000000041732
  3. Semin Ophthalmol. 2025 Mar 01. 1-13
    Global Research Trends in Endoscopic and External Dacryocystorhinostomy: A Bibliometric Analysis.
    Ahmet Ufuk Kılıçtaş, Furkan Ozer.
       AIM: To carry out an exhaustive bibliometric analysis of the existing literature on endoscopic dacryocystorhinostomy (DCR), with a view to comparing this with the trend in external DCR.
    METHODS: A total of 1,230 publications on endoscopic DCR and 1,036 on external DCR were retrieved from the Web of Science databases and analyzed. Data on publication types, indexing categories, journal and publisher contributions, temporal trends, authorship networks, frequently used keywords, and country-level contributions were evaluated. Co-authorship and keyword co-occurrence networks were visualized to identify collaboration patterns and thematic focuses. Citation metrics, including the top 100 most-cited publications, were also assessed.
    RESULTS: Original articles accounted for over 85% of the publications in both endoscopic and external DCR literature. The research is predominantly concentrated in ophthalmology (44.4%) and otorhinolaryngology (32.1%) for endoscopic DCR, with most publications indexed in the Science Citation Index Expanded (77.3%). The number of endoscopic DCR publications peaked in 2020, while external DCR peaked in 2015. Ali Mohammad Javed emerged as the most prolific author with 78 publications, and the co-authorship network revealed strong interdisciplinary collaborations. India led the publication output for both endoscopic (16.9%) and external (15.7%) DCR, followed by the United States and Turkey. Frequently used keywords such as "dacryocystorhinostomy" and "epiphora" highlighted the primary clinical focus.
    CONCLUSION: The bibliometric analysis highlights the increasing trend in publications over the last decade, indicating an escalating interest in minimally invasive methods, with endoscopic DCR being a prominent approach for the management of nasolacrimal duct obstruction. Key contributors, impactful journals, and strong collaborations drive innovation in the field. However, research gaps remain in patient-reported metrics, and contributions from underrepresented regions. Addressing these areas through international and multidisciplinary efforts will advance the field further.
    Keywords:  Bibliometric; endoscopic dacryocystorhinostomy; external dacryocystorhinostomy
    DOI:  https://doi.org/10.1080/08820538.2025.2474032
  4. Neurosurg Focus. 2025 03 01. 58(3): E14
    Female authorship in global research: a bibliometric study of high- and low-income country collaborations.
    Francesca Totis, Filippo Emanuele Colella, Adrian Safa, Roberto Stefini, Delia Cannizzaro.
       OBJECTIVE: The aim of this study was to examine female authorship in research from collaborations between high-income countries (HICs) and lower-middle-income and low-income countries (LMICs/LICs) across two time periods: 2018-2020 and 2021-2023.
    METHODS: A bibliometric analysis of neurosurgical research articles from the Scopus database, published between 2018 and 2023, was performed to investigate collaboration trends between HICs and LMICs/LICs. Only neurosurgical publications were included, and female authors were identified based on names traditionally associated with female gender identity, verified through online searches and tools such as Genderize.io. Articles with more than 25 authors, commentaries, letters, and news items were excluded to ensure a focus on original research. The selected articles spanned various neurosurgical specialties and were restricted to English-language journals with an impact factor greater than 1. The country affiliations of first, corresponding, and last authors were categorized using the 2018 World Bank classification to understand collaboration patterns across income levels.
    RESULTS: The analysis revealed a steady increase in neurosurgical publications from 2018 to 2023, with a notable rise in the second triennium (2021-2023). Authors from HICs consistently held the majority of first, corresponding, and last authorship positions. Concerning first authorship, authors with affiliations from HICs increased from 66% in the first triennium to 75% in the second. Similarly, corresponding authors from HICs increased from 75% to 82% over the same period. Male authors dominated all key authorship roles, with 127 male-led first authorships compared with 46 female-led first authorships in the second triennium. This male predominance persisted in corresponding and last author roles as well.
    CONCLUSIONS: Global neurosurgical research is growing but significant gender disparities persist, especially in LMICs/LICs, with female researchers underrepresented in key authorship roles, requiring targeted efforts to address systemic barriers and promote gender equity in academic leadership.
    Keywords:  academic neurosurgery; gender disparity; global neurosurgery; world health
    DOI:  https://doi.org/10.3171/2024.12.FOCUS24815
  5. Nurse Educ Today. 2025 Feb 15. pii: S0260-6917(25)00068-1. [Epub ahead of print]149 106633
    The power of role play in nursing education: A bibliometric analysis and visualization.
    Amine Terzi, Yasemin Yildirim, Ipek Deveci Kocakoc.
       AIM: This study aims to conduct a bibliometric analysis of research involving the role play method in nursing education by visualizing global research trends in this area, identifying the journals with the most publications, and examining author and country collaborations.
    METHODS: The study utilized data retrieved from the Web of Science (WOS) database and conducted analyses using Vosviewer, Bibliometrix, and custom-written Python scripts. 281 publications were included in the bibliometric analysis.
    RESULTS: Research on the role play method spans from 1993 to 2024. The top three research areas are; "Nursing," "Education & Educational Research" and "Health Care Sciences & Services". The dataset includes articles from 119 different journals, with minimal collaboration observed among authors, countries, and institutions.
    CONCLUSION: This study thoroughly explored global trends and key areas of role play in nursing research using bibliometric and visualization analyses. The analysis results showed that the role play method is gaining growing recognition in nursing education and the development of clinical skills. Future research is recommended to explore its effectiveness across diverse cultural and clinical contexts and encourage interdisciplinary collaborations to expand the knowledge base.
    Keywords:  Bibliometric analysis; Education; Nursing; Role playing
    DOI:  https://doi.org/10.1016/j.nedt.2025.106633
  6. Drug Des Devel Ther. 2025 ;19 1305-1321
    A Bibliometric and Visual Analysis of Oliceridine Research (2013-2024).
    Cheng Song, Xinxing Huang, Nianping Chen, Qiliang Song, Yuanli Qiu.
       Purpose: To explore and analyze the current research progress, hotspots, and future trends in oliceridine research using bibliometric methods.
    Patients and Methods: We searched the Web of Science (WOS) database utilizing the keywords TS = ("oliceridine*" OR "TRV 130*" OR "TRV-130*" OR "olinvyk*" OR "TRV130*" OR "C22H31CIN2O2S*") for relevant research literature on oliceridine from its inception to June 16, 2024. Bibliometric methods were applied, and analysis software such as VOSviewer and CiteSpace were used to visualize the publication timeline, authors, countries and regions, keywords, sources of literature, research hotspots, and co-cited documents related to oliceridine. Co-occurrence and aggregation analyses were conducted, and maps relevant to institutional cooperation were generated.
    Results: A total of 151 relevant articles were retrieved and included in the final analysis. Most articles were published between 2020 and 2021. The United States has the highest number of publications and citations in this field. Molecular structure development is a pivotal point in this field. Research hotspots were diverse, including acute pain, opioid receptors, β-arrestin, postoperative pain, therapeutic window, respiratory depression, clinical trials, and chronic pain.
    Conclusion: Oliceridine, a newly developed analgesic, has garnered global interest. The USA is a leading contributor to this field. Recent research has shifted from basic studies to clinical practice.
    Keywords:  bibliometrics; oliceridine; opioid drugs; research trends
    DOI:  https://doi.org/10.2147/DDDT.S497186
  7. Cureus. 2025 Jan;17(1): e78161
    Evaluating Growth in Dry Socket Publications: A Bibliometric Analysis.
    Manju Philip, Ikram Ui Haq, Bandar AlMutairi, Saad Bin Shabib, Muhannad A Alshehri, Ibrahim Almuhanna.
      Dry socket, a common postextraction complication, occurs when the blood clot in the tooth socket fails to form or is dislodged, leading to severe pain and delayed healing. This study aimed to analyze the publication trends and key features of dry socket research published from 1905 to 2024 worldwide. A quantitative bibliometric approach was employed to extract data from the Web of Science database. The search strategy included Topics = ("dry socket" OR "alveolar osteitis") and covered publications up to December 31, 2024. The search captured all types of documents to provide a comprehensive overview. The study analyzed and extracted several bibliometric parameters, including the classification of clinical versus nonclinical studies, level of evidence, trends in research, and citations over time, as well as information on the leading journals, countries, institutions, authors, and top keywords. Data analysis was conducted using Microsoft Excel (version 16, Microsoft Corporation, Redmond, WA) and VOSviewer (version 1.6.10, Centre for Science and Technology Studies, Leiden University, The Netherlands) software. Our search identified 713 documents, averaging 18.85 citations per publication. Most studies were clinical, and level 2 was the most frequently observed level of evidence. Approximately 82% of the publications were released in the past 24 years, from 2001 to 2024. Over one-third of the literature was published in the top 10 journals, with the Journal of Oral and Maxillofacial Surgery being the most preferred. The United States produced the most research and had the highest citation impact. The Saveetha Institute of Medical and Technical Sciences contributed the largest number of publications, while The University of Manchester had the highest citation impact. Majid Eshghpour was the most productive author. The most influential keywords identified were "dry socket", "alveolar osteitis", and "tooth extraction". This bibliometric study provides valuable insights into the evolving body of research on dry sockets, offering a clear picture of the leading topics, influential journals, and key contributors shaping this field. Future research efforts should continue to build on these findings, focusing on innovative clinical interventions, preventive measures, and further exploration of less studied areas.
    Keywords:  alveolar osteitis; bibliometric; dry socket; publication; research productivity
    DOI:  https://doi.org/10.7759/cureus.78161
  8. Front Neurosci. 2025 ;19 1511350
    Application of artificial intelligence in Alzheimer's disease: a bibliometric analysis.
    Sijia Song, Tong Li, Wei Lin, Ran Liu, Yujie Zhang.
       Background: Understanding how artificial intelligence (AI) is employed to predict, diagnose, and perform relevant analyses in Alzheimer's disease research is a rapidly evolving field. This study integrated and analyzed the relevant literature from the Science Citation Index (SCI) and Social Science Citation Index (SSCI) on the application of AI in Alzheimer's disease (AD), covering publications from 2004 to 2023.
    Objective: This study aims to identify the key research hotspots and trends of the application of AI in AD over the past 20 years through a bibliometric analysis.
    Methods: Using the Web of Science Core Collection database, we conducted a comprehensive visual analysis of literature on AI and AD published between January 1, 2004, and December 31, 2023. The study utilized Excel, Scimago Graphica, VOSviewer, and CiteSpace software to visualize trends in annual publications and the distribution of research by countries, institutions, journals, references, authors, and keywords related to this topic.
    Results: A total of 2,316 papers were obtained through the research process, with a significant increase in publications observed since 2018, signaling notable growth in this field. The United States, China, and the United Kingdom made notable contributions to this research area. The University of London led in institutional productivity with 80 publications, followed by the University of California System with 74 publications. Regarding total publications, the Journal of Alzheimer's Disease was the most prolific while Neuroimage ranked as the most cited journal. Shen Dinggang was the top author in both total publications and average citations. Analysis of reference and keyword highlighted research hotspots, including the identification of various stages of AD, early diagnostic screening, risk prediction, and prediction of disease progression. The "task analysis" keyword emerged as a research frontier from 2021 to 2023.
    Conclusion: Research on AI applications in AD holds significant potential for practical advancements, attracting increasing attention from scholars. Deep learning (DL) techniques have emerged as a key research focus for AD diagnosis. Future research will explore AI methods, particularly task analysis, emphasizing integrating multimodal data and utilizing deep neural networks. These approaches aim to identify emerging risk factors, such as environmental influences on AD onset, predict disease progression with high accuracy, and support the development of prevention strategies. Ultimately, AI-driven innovations will transform AD management from a progressive, incurable state to a more manageable and potentially reversible condition, thereby improving healthcare, rehabilitation, and long-term care solutions.
    Keywords:  Alzheimer’s disease; CiteSpace; VOSviewer; artificial intelligence; bibliometric analysis; machine learning
    DOI:  https://doi.org/10.3389/fnins.2025.1511350
  9. Front Immunol. 2025 ;16 1534660
    Research trends of inflammation in autism spectrum disorders: a bibliometric analysis.
    Yajing Chen, Xiaohuan Du, Xianming Zhang, Fang Li, Shuwei Yuan, Wenjing Wang, Zengyan Zhu, Mei Wang, Chao Gu.
       Background: Inflammation has been recognized as a significant factor in the pathophysiology of autism spectrum disorders (ASD), which have garnered increasing scholarly attention over the past few decades. This study aims to explore research trends related to inflammation and ASD through bibliometric analysis.
    Method: A comprehensive literature search was conducted in the Web of Science Core Collection (WoSCC) on August 28, 2024. This study was restricted to literature published in English. The bibliometric analysis utilized VOSviewer, CiteSpace, and the R package "bibliometrix" to visualize collaborations, keyword co-occurrences, and emerging research trends.
    Results: A total of 1,752 articles addressing inflammation and ASD were published, demonstrating a consistent upward trend in research output. The United States emerged as the country with the highest volume of publications. Saleh A. Bakheet was identified as the most prolific authors, significantly contributing to the literature with 54 publications. The University of California System was recognized as the most productive institution in this area of study. The journal of Brain Behavior and Immunity was noted as a prominent venue for publication in this field, exhibiting high citation metrics that reflect its considerable influence. The keyword "children" was the most frequently occurring term, with other significant terms including "oxidative stress" and "brain." The keyword burst analysis revealed notable periods of increased research focus on topics such as "inflammatory bowel disease," "cytokine production," "neurodevelopmental disorders," and "microbiota."
    Conclusion: This bibliometric analysis highlights the growing scholarly attention devoted to the relationship between inflammation and ASD. Significant contributions and emerging trends emphasize the pivotal role of neuroinflammation in ASD, indicating a necessity for further exploration in this domain.
    Keywords:  autism spectrum disorder; bibliometrics; citation analysis; inflammation; neuroinflammation
    DOI:  https://doi.org/10.3389/fimmu.2025.1534660
  10. Front Med (Lausanne). 2025 ;12 1513213
    Global research on NK cells in miscarriage: a bibliometric study.
    Yinan Wang, Xiaoqin He, Chaogang Yang, Jinli Ding.
       Background: This study aimed to assess the evolution, trends, and research hotspots of publications related to natural killer (NK) cells and miscarriage.
    Methods: The literature on NK cells and miscarriage was retrieved from the Web of Science Core Collection. VOSviewer and CiteSpace were used to analyze the publication years, countries, institutions, journals, highly cited authors, categories, and citation bursts of keywords.
    Results: A total of 1,275 articles were analyzed. The annual publication outputs showed steady growth, with the majority of publications in 2020 and citations in 2022. The number of publications in this field fluctuated from 1981 to 2023, with a slight downward trend observed. However, the number of citations increased steadily until 2023, followed by a minor decline. The United States contributed the highest number of publications and had the highest h-index. The American Journal of Reproductive Immunology ranked first in terms of number of publications and h-index. Reproductive biology, immunology, and obstetrics and gynecology were the most representative disciplines. Kwak-kim J, Chaouat G, and Croy BA were the top three most productive authors in the field. Keyword burst analysis demonstrated that the immune system and cytotoxicity receptors were current research hotspots.
    Conclusion: This is the first bibliometric study to comprehensively summarize trends and advances in the study of NK cells in miscarriage. This information highlights the recent research frontiers and emerging directions and provides a reference for subsequent research in the future.
    Keywords:  CiteSpace; NK cells; VOSviewer; bibliometric analysis; miscarriage
    DOI:  https://doi.org/10.3389/fmed.2025.1513213
  11. Front Med (Lausanne). 2025 ;12 1518640
    Bibliometric analysis of preoperative radiotherapy for locally advanced rectal cancer: evolution and future.
    Zhen-Hong Weng, Hao-Kai Hu, Zi-Shan Zhou, Li-Sheng Huang, Bin-Bin Chen, Jia-Rui Lin.
       Background: Preoperative radiotherapy of rectal cancer has been a hot topic of research in recent years with the introduction of total neoadjuvant therapies and immunotherapeutic agents. We utilized bibliometrics and visualization analysis to examine studies in this field, aiming to identify current hotspots and research trends.
    Method: We searched the Web of Science database for all publications related to preoperative radiotherapy of rectal cancer in the past 10 years. Using bibliometric analysis software, such as VOSviewer, CiteSpace and R-studio, we extracted and analyzed the data, summarizing the publication output of countries, institutions, authors, and journals in this field, and analyzing their relationships. We also summarized the keywords, burst words, and most cited articles, and analyzed the relationships among them.
    Results: We found 794 publications in the field, sourced from 217 journals or books, involving 5,805 authors from various organizations and countries. Through bibliometric analysis, we observed a growing trend in the number of publications in preoperative radiotherapy of rectal cancer over the past 10 years. China, United States and Italy were the top countries in terms of publication output. Sun Yat-sen University, Fujian University, and Fudan University were the top three medical centers in terms of publication output, while Leiden University from Netherlands led globally in terms of citation impact. Professor Zhen Zhang, Sanjun Cai, and Ji Zhu were the top three authors with the highest publication output. The most highly cited journals in this field includes "The Lancet Oncology," "J Clinical Oncology," and "Annals of Oncology." Journals such as "Radiotherapy and Oncology," "Frontiers in Oncology," and "BMC Cancer" have the highest number of articles published. Based on the analysis of keywords and burst words, we found that "preoperative chemoradiation" and "oral capecitabine" were the research hotspots before 2016, while the focus shifted to "short-course radiotherapy" and "long-term outcomes" after 2017. Currently, the most frequently cited publications mainly summarize multicenter clinical studies and total neoadjuvant treatment models and immunotherapy.
    Conclusion: Research on preoperative radiotherapy of rectal cancer is increasing year by year, and attracting attention from high-cited journals such as "The Lancet Oncology," "JCO," and "Annals of Oncology." Based on current data, the total neoadjuvant treatment models and radiation combined with immunotherapy are the research trends.
    Keywords:  bibliometrics; locally advanced; preoperative; radiotherapy; rectal cancer
    DOI:  https://doi.org/10.3389/fmed.2025.1518640
  12. IBRO Neurosci Rep. 2025 Jun;18 311-322
    Research trends and hot spots in obesity-induced pain: A bibliometric analysis of the last 20 years.
    Lei Gao, Yazhou Wen, Kunlin Guo, Renqi Li, Mao Mao, Shanwu Feng, Xian Wang.
       Background: Obesity can directly lead to allodynia, increase the incidence of chronic pain, and aggravate existing pain. However, the mechanisms underlying obesity-related or obesity-induced pain are still not understood. Herein, we performed a comprehensive bibliometric analysis of obesity-related or obesity-induced pain, aiming to analyze the current trends and hot spots as well as explore the underlying mechanisms.
    Methods: We searched reviews and articles on obesity-related or obesity-induced pain from 2005 to 2024 via the Web of Science Core Collection (WoSCC) database. We subsequently conducted bibliometric analysis employing WPS Office, a web-based bibliometric analysis platform (https://bibliometric.com), VOSviewer, Pajek, and CiteSpace.
    Results: In total, 347 papers were identified for bibliometric analysis. The country, institution, and journal with the greatest influence were the USA, Albert Einstein College of Medicine, and Headache, respectively. Dr. Lipton RB and Dr. Karppinen J were the top 2 influential authors on the basis of their significant number of publications and citations. The keywords for the latest burst were "inflammation," "risk," "neuropathic pain," "gene-related peptide," "knee osteoarthritis," and "validation." Notably, the article titled "The association between chronic obesity and pain" by Okifuji A received the highest number of citations as well as the strongest citation burst. He and colleagues noted a significant correlation between obesity and pain in terms of clinical manifestations, but this connection is indirect and is modulated by certain biomechanical and structural alterations linked to obesity, inflammatory agents, mood disorders, sleep disturbances, and lifestyles.
    Conclusion: There has been a notable surge in the number of articles published in the last two decades. The investigation into neuroendocrine and neuroimmune mechanisms underlying obesity-related or obesity-induced pain is expected to be a hot spot in the coming years. A potential strategy for treating chronic obesity and pain should pay attention to particular endocrine regulators, inflammatory cytokines, or immune cells that serve as central elements or crucial signaling pathways within this regulatory system.
    Keywords:  Bibliometric analysis; CiteSpace; Obesity; Pain; Research trends; VOSviewer
    DOI:  https://doi.org/10.1016/j.ibneur.2025.02.001
  13. Orphanet J Rare Dis. 2025 Mar 04. 20(1): 101
    Global research dynamics in urea cycle disorders: a bibliometric study highlighting key players and future directions.
    Yan Wang, Xueer Wang, Huiqin Zhang, Binhui Zhu.
       BACKGROUND: This study aims to explore the research hotspots and trends of urea cycle disorders through bibliometric analysis.
    METHODS: Using the Web of Science Core Collection as the database, we retrieved literature published from 2007 to 2024. We utilized CiteSpace, VOSviewer, and Bibliometrix R package to conduct a bibliometric visualization analysis, including the number of publications, citation frequency, publishing countries, institutions, journals, authors, references, and keywords.
    RESULTS: A total of 926 publications on UCDs were published in 318 journals by 4807 authors at 1494 institutions from 49 countries/regions. The USA had the highest number of publications and citation frequency. The Children's National Health System in the USA published the most literature. The most frequent collaboration was between the USA and Germany. The journal with the most publications was Molecular Genetics and Metabolism. The author with the most publications was Johannes Häberle. The most frequently cited reference was the 2019 publication of the revised guidelines for the diagnosis and management of UCDs. The identified future research hotspots are expected to focus on "gene therapy", "mutations" and "efficacy".
    CONCLUSION: This study is the first bibliometric analysis of publications in the field of UCDs. These findings suggest that European and American countries dominate UCD research, it is necessary to further strengthen global cooperation in the field of UCDs. Early detection of the disease and emerging therapies, including gene therapy, are likely to be future research hotspots.
    Keywords:  Bibliometric analysis; CiteSpace; Inborn errors of metabolism; Urea cycle disorder; VOSviewer
    DOI:  https://doi.org/10.1186/s13023-025-03625-3
  14. Rev Bras Ortop (Sao Paulo). 2025 Feb;60(1): 1-14
    The Top 100 Most Cited Articles on Anterolateral Ligament: A Bibliometric Analysis and Review.
    Camilo Partezani Helito, Valdiane Pereira de Araujo, Sergio Marinho de Gusmao Canuto, Pedro Baches Jorge, Vitor Barion Castro de Padua, Diego Ariel de Lima.
      Objectives  To conduct a bibliometric analysis aimed at evaluating the 100 most frequently cited articles concerning the anterolateral ligament (ALL). Methods  A thorough search was executed using the Scopus database with the keyword "Anterolateral Ligament." The analysis incorporated technical notes, systematic reviews focusing on clinical outcomes and/or complications, clinical studies, and foundational scientific articles (both cadaveric and biomechanical). Case reports or personal opinion articles were omitted from the review. The 100 articles with the highest citation counts were examined using the Bibliometrix R-package software, which evaluated total citations, study type, country of origin, journal of publication, affiliated institution, and most prolific authors. Results  The 100 articles accumulated 11,192 citations, ranging from 44 to 703 per article. Most articles (69) were published between 2015 and 2017, predominantly focusing on anatomical and biomechanical studies. The United States was the leading country of publication (29%), followed by the United Kingdom (15%), Brazil (14%), France (13%), and Belgium (8%). The top five journals were the American Journal of Sports Medicine (31%), Arthroscopy (17%), Knee Surgery, Sports Traumatology, Arthroscopy (17%), Arthroscopy Techniques (5%), and Skeletal Radiology (4%). The most prolific authors were Sonnery-Cottet (21), Helito (17), with Musahl, Saithna, and Thaunat each contributing 11 articles. Sonnery-Cottet had the highest citation count, with 2,421. Conclusion  The analysis reveals that research on the ALL is growing, with significant contributions in anatomy and biomechanics. However, further studies are needed to establish the best indications for reconstruction and optimal surgical techniques.
    Keywords:  bibliometric analysis; knee; ligaments, articular; publications
    DOI:  https://doi.org/10.1055/s-0044-1800939
  15. Health Sci Rep. 2025 Mar;8(3): e70314
    Trends in Research on Hypertrophic Cardiomyopathy and Mitochondria From 2003 to 2023: A Bibliometric Analysis.
    Lulu Yang, Heng Zhang, Zhiyang Zhu, Jianming Wang, Xiaojuan Liu, Lijie Lu, Jinliang Huang, Miaoran Wang, Zhengchuan Zhu.
       Background: Mitochondria have emerged as a significant and promising area of research in hypertrophic cardiomyopathy (HCM). However, there is a notable scarcity of bibliometric studies in this field. Our aim is to conduct a bibliometric analysis of mitochondrial research in HCM, delineating research hotspots and trends to aid in understanding the focal points and evolving trajectories of both basic and clinical research.
    Methods: Articles and reviews related to mitochondrial research in hypertrophic cardiomyopathy (HCM) from 2003 to 2023 were filtered from the Web of Science database. CiteSpace software was utilized to generate knowledge maps including keyword analysis, authorship networks, countries of origin, and journal distributions.
    Results: A total of 285 relevant articles on HCM and mitochondria were included, with publication output steadily increasing over the years. These publications originated from 47 countries and regions, with the United States and China contributing the most publications. Primary research institutions included UDICE-French Research Universities, Centro de Investigacion Biomedica en Red, and Institut National de la Sante et de la Recherche Medicale (Inserm). J BIOL CHEM and P NATL ACAD SCI USA emerged as prominent journals with substantial research output and authority. We identified 520 authors, with Rachid Boutoual and Scot C Leary having the highest publication outputs, while BJ Maron and D Ghezzi were cited most frequently. Through hotspot analysis, we identified frequently occurring keywords such as Hypertrophic cardiomyopathy, Oxidative stress, Heart failure, Lactic acidosis, Mutations, Disease, Dilated cardiomyopathy, Cardiomyopathy, Deficiency, and Cardiac hypertrophy. Mitochondrial diseases associated with HCM, including Leigh syndrome, Barth syndrome (BTHS), heart failure, arrhythmias, and cardiovascular diseases, represent current and evolving research areas.
    Conclusion: Through bibliometric methods, we have elucidated the research hotspots and trends concerning hypertrophic cardiomyopathy (HCM) and mitochondria. The investigation of mitochondria, particularly in the context of cardiovascular medicine and HCM, demonstrates an unstoppable momentum. Research on mitochondria in HCM predominantly focuses on mechanisms, cardiovascular diseases, and therapeutic approaches, which will serve as pivotal areas for future exploration.
    Keywords:  CiteSpace; bibliometric analysis; hypertrophic cardiomyopathy; mitochondria; visual analysis
    DOI:  https://doi.org/10.1002/hsr2.70314
  16. Arthrosc Sports Med Rehabil. 2025 Feb;7(1): 100958
    A Bibliometric Review of the Top 100 Most Cited Articles in Hip Preservation, Not Counting Self-Citations.
    Tyler R Dorobek, Max V Golden, Andrew K Kirchmeier, Jeanne G Moua, Andrea M Spiker.
       Purpose: To summarize the characteristics of the top 100 most-cited publications related to hip preservation, not counting self-citation.
    Methods: Databases accessible through ISI Web of Science were queried for articles related to hip preservation between 1965 and June 2022. Analysis included citation number, visual network mapping, publication year, geographic distribution, authorship, impact factor, citation density, and institution. Data analysis was performed excluding self-citations.
    Results: The top 100 most cited articles in hip preservation had citations ranging between 151 and 2,001, with publication years between 1965 and 2018. An increase in citation density over time was observed. Fifty-seven percent of articles were from the United States, 23% from Switzerland, and 8% from Canada; 57% of the articles were published in the 2000s, and a majority were Level IV Evidence (n = 62). Clinical Orthopaedics and Related Research led in number of publications (n = 32) and mean citations (n = 353) followed by Arthroscopy-The Journal of Arthroscopic and Related Surgery (n =23) and American Journal of Sports Medicine (n = 11). "Femoroacetabular impingement" (occurrences = 19) and "arthroscopy" (15) have been focal keywords since the turn of the 21st century, whereas in the 20th century, "acetabulum" (occurrences = 2) was the predominant keyword.
    Conclusions: The 100 most-cited articles in hip preservation, not counting self-citation, were published between 1965 and 2018. Citation density increased over time. The majority of articles were published in the United States and in Clinical Orthopaedics and Related Research. The focus in hip preservation has expanded from acetabulum pathology to extensive work across topics including femoroacetabular impingement, capsular biomechanics, and arthroscopy innovation.
    Level of Evidence: Level IV, descriptive epidemiology study using large database.
    DOI:  https://doi.org/10.1016/j.asmr.2024.100958
  17. Neurocirugia (Astur : Engl Ed). 2025 Mar 03. pii: S2529-8496(25)00012-7. [Epub ahead of print] 500656
    Global Trends in Neurosurgical Research: Insights from the Top 100 Most-Cited Articles.
    R Garcia-Armengol, S A Menéndez-Girón, C Hostalot, A C Pérez-Balaguero, C J Dominguez, A Rodriguez-Hernandez.
       OBJECTIVE: This study aimed to identify and analyze the 100 most-cited articles in neurosurgical journals over the past 20 years.
    METHODS: The Thomson Reuters Web of Science citation index was used to analyze articles from high-impact neurosurgical journals identified via Journal Citation Reports. Data extracted included citations, citations per year, title, authors, year, country, institution, journal, study type, and thematic area. Citation analysis identified the most impactful articles. A bibliometric analysis compared trends between 2012-2022 and 2001-2011. Descriptive statistics and Pearson correlation were applied to examine the relationship between publication year and citation count. Stata V14.2 was used for statistical analysis.
    RESULTS: Citations for the top 100 articles ranged from 194 to 1,501. "Journal of Neurosurgery" and "Neurosurgery" published the most-cited articles, with peak productivity in 2012 and 2013. The USA was the leading country in article contributions. Neuro-oncology, especially tumor studies, was the dominant thematic field.
    CONCLUSIONS: The bibliometric analysis highlighted a strong centralization in neurosurgical research, with most highly cited articles coming from two major journals, largely from the United States. This reveals the significant influence of a few key contributors in global neurosurgery.
    Keywords:  análisis bibliométrico; bibliometric analysis; citas; citations; neurosurgical journals; revistas neuroquirúrgicas; top 100
    DOI:  https://doi.org/10.1016/j.neucie.2025.500656
  18. Intractable Rare Dis Res. 2025 Feb 28. 14(1): 55-66
    Research hotspots and trends of the SLC26A4 gene-related hearing loss from the perspective of knowledge graph.
    Yue Li, Cheng Wen, Yiding Yu, Lin Deng, Shan Gao, Lihui Huang.
      This article aims to identify research hotspots and trends in research on SLC26A4 gene-related hearing loss through bibliometric and visual analyses, providing a reference and direction for future research. Publications on SLC26A4 gene research in hearing loss from 1994 to 2023 were retrieved from the Web of Science Core Collection database. Bibliometric analysis was conducted using the Bibliometrix 4.0.0 R package, CiteSpace 6.2.R6 software, and VOSviewer 1.6.20. The analysis encompassed journals, authors, keywords, institutions, countries, and references. Based on the analysis results, network maps were generated to evaluate collaborations among authors, countries, institutions, keyword co-occurrences, and co-citation references. This study identified 1,308 publications from 62 countries. Annual publication numbers have increased with fluctuations, showing rapid growth since 2011. The USA emerged as the leading contributor in this field based on scientific production, citations, and cooperation networks. International Journal of Pediatric Otorhinolaryngology had the highest number of publications, while Laryngoscope was the most cited journal. Harvard University was the most productive institution. Key researchers included Dai Pu, Griffith Andrew J., and Usami Shin-Ichi. There have been active collaborations between countries, authors, and institutions. The primary research topics focused on genotype-phenotype correlations, genetic screening, diagnostic advancements, and exploration of pathogenic mechanisms. Research on SLC26A4 gene-related hearing loss has notably increased since 2011, with ongoing clinical investigations and basic research efforts. Future studies may further explore disease mechanisms and potential therapeutic interventions related to the SLC26A4 gene.
    Keywords:  SLC26A4 gene; hearing loss; hotspots; research trends; visualization analysis
    DOI:  https://doi.org/10.5582/irdr.2024.01072
  19. Front Microbiol. 2025 ;16 1541792
    Research hotspots and development trends of Brucellar spondylitis in the past 30 years: a bibliometric analysis.
    Jinyu Wu, Hongxia Yuan, Hongchao Chen.
       Objective: With the growing emphasis on global health issues, Brucellar spondylitis, a serious complication of brucellosis, has received increasing attention from researchers. This study employed bibliometric analysis to visually illustrate the scientific advancements and research trends in the field of Brucellar spondylitis research, providing a scientific basis for public health prevention and control strategies.
    Method: The data were sourced from the Web of Science Core Collection database, covering the period from January 1, 1984, to December 31, 2023. Network analyses of countries, institutions, authors, and keyword collaborations, as well as co-citation analyses of journals and references, were conducted using CiteSpace software. VOSviewer software was used to analyze the co-occurrence and hotspots of keywords.
    Result: A total of 246 relevant documents were retrieved, comprising 221 articles and 25 review articles. From 1984 to 2023, the number of research publications exhibited a generally fluctuating upward trend. Turkey and China emerged as the primary contributing countries in this field, with Xinjiang Medical University identified as the most productive research institution. Additionally, Juan D. Colmenero is recognized as the author with the highest number of published articles and citations. "Clinical Infectious Diseases" is regarded as the most influential journal in this domain. Among the 404 keywords analyzed by CiteSpace, the top 10 high-frequency keywords included spondylitis, complication, melitensis, osteoarticular complication, diagnosis, infection, clinical characteristics, epidural abscess, arthritis, and feature. A total of 14 clusters were formed. In the burst analysis of the top 15 keywords, "instrumentation" exhibited the highest burst intensity, while "arthritis" demonstrated the longest burst duration. Emerging keywords include "experience," "ankylosing spondylitis," "China," and "instrumentation."
    Conclusion: This study is the first bibliometric analysis in the field of Brucellar spondylitis, which revealed that the research hotspots in this field included the clinical characteristics of the disease, the management of complications, and treatment strategies. The development trend may involve enhancements in early diagnostic methods and advancements in surgical instruments. This study serves as a valuable reference for future research directions.
    Keywords:  Brucella; Brucellar spondylitis; CiteSpace; VOSviewer; bibliometric analysis; infectious disease
    DOI:  https://doi.org/10.3389/fmicb.2025.1541792
  20. Front Surg. 2025 ;12 1509556
    Research trends and hotspots of Colles fracture: a bibliometric analysis from 1980 to 2023.
    Chaoxi Zhou, Guangrong Yu, Qinglei Wang.
       Background: Colles fractures, a common type of distal radius fracture, predominantly affect older adults and are often associated with osteoporosis. Understanding the epidemiology, treatment methods, and complications of Colles fractures is crucial for improving patient outcomes.
    Objective: This bibliometric analysis aims to assess the trends, influential research, and collaboration patterns in Colles fracture studies from 1980 to 2023, providing insights into emerging areas of research.
    Methods: Literature was retrieved from the Web of Science Core Collection (WoSCC), Science Citation Index Expanded (SCI-EXPANDED) using the search term "Colles fracture". A total of 948 relevant documents, including 901 articles and 47 reviews, were analyzed. VOSviewer, CiteSpace, and bibliometrix were utilized for visualization and data analysis, focusing on publication trends and hotspots.
    Results: The analysis revealed a steady increase in publications and citation counts, peaking around 2010, with a notable decline in publication output post-2010 while citations continued to rise. The USA led in both publication volume and citation impact, with significant contributions from England, Canada, Germany, and Japan. Key authors such as Cooney WP and Jupiter JB were identified as influential, while the Journal of Hand Surgery-American Volume emerged as the leading publication outlet. Keyword analysis indicated a growing emphasis on epidemiology and outcomes research, reflecting broader public health concerns.
    Conclusion: This bibliometric analysis highlights the evolving research on Colles fractures from 1980 to 2023. Despite a plateau in publication rates, citations continue to increase, indicating the lasting influence of earlier studies. Significant advancements have been made in treatment methods, particularly in external fixation (EF) and open reduction internal fixation (ORIF). The growing interdisciplinary focus on Colles fractures, osteoporosis, and rehabilitation underscores the need for continued research to enhance clinical outcomes and preventive measures.
    Keywords:  Colles fracture; bibliometric; external fixation; nonoperative; open reduction internal fixation; osteoporosis; rehabilitation
    DOI:  https://doi.org/10.3389/fsurg.2025.1509556
  21. Front Neurol. 2025 ;16 1463080
    Research trends and hotspots in the surgical treatment of peripheral nerve injuries of the upper limb from 2000 to 2024: a bibliometric visualization study.
    Jian Ruan, Hekun He, Xueyuan Li, Hong Chen.
       Purpose: Surgical treatment plays a crucial role in the management of peripheral nerve injuries of the upper limb, but little bibliometric analysis has been conducted on it. This study was aimed to examine the global trends and hotspots in the field of Peripheral nerve injuries of the upper limb.
    Methods: Publications on the surgical treatment of peripheral nerve injuries of the upper limb in the Web of Science database were collected between 2000 to 2024. CiteSpace and VOSviewer software was applied to visualize and analyze publications, countries, institutions, journals, authors, references, and keywords.
    Results: A total of 751 articles were collected, the most active countries in this field were the United States and China. The authors with the most publications were Mackinnon, Susan E from the United States, and Xu WD and Gu YD from China. JOURNAL OF HAND SURGERY AMERICAN VOLUME was the journal with the most published. Based on keywords, the current research hotspots primarily revolved around nerve transfer, brachial plexus and reconstruction.
    Conclusion: The results of this bibliometric study provide clinical trends and hotspots in the surgical treatment of peripheral nerve injuries of the upper limb over the past 24 years, which may help researchers to identify clinical trends and explore new treatment in the field of peripheral nerve injuries.
    Keywords:  CiteSpace; bibliometric analysis; peripheral nerve injuries; surgery; upper limb
    DOI:  https://doi.org/10.3389/fneur.2025.1463080
  22. World J Hepatol. 2025 Feb 27. 17(2): 95624
    Global landscape of hepatic organoid research: A bibliometric and visual study.
    Tao Li, Rong-Qiang Bo, Jun Yan, Nadia L Johnson, Meng-Ting Liao, Yuan Li, Yan Chen, Jie Lin, Jian Li, Fu-Hao Chu, Xia Ding.
       BACKGROUND: Hepatic organoid-based modelling, through the elucidation of a range of in vivo biological processes and the recreation of the intricate liver microenvironment, is yielding groundbreaking insights into the pathophysiology and personalized medicine approaches for liver diseases.
    AIM: This study was designed to analyse the global scientific output of hepatic organoid research and assess current achievements and future trends through bibliometric analysis.
    METHODS: Articles were retrieved from the Web of Science Core Collection, and CiteSpace 6.3.R1 was employed to analyse the literature, including outputs, journals, and countries, among others.
    RESULTS: Between 2010 and 2024, a total of 991 articles pertaining to hepatic organoid research were published. The journal Hepatology published the greatest number of papers, and journals with an impact factor greater than 10 constituted 60% of the top 10 journals. The United States and Utrecht University were identified as the most prolific country and institution, respectively. Clevers H emerged as the most prolific author, whereas Huch M had the highest number of cocitations, suggesting that both are ideal candidates for academic collaboration. Research on hepatic organoids has exhibited a progressive shift in focus, evolving from initial investigations into model building, differentiation research in stem cells, bile ducts, and progenitor cells, to a broader spectrum encompassing lipid metabolism, single-cell RNA sequencing, and therapeutic applications. The phrases exhibiting citation bursts from 2022 to 2024 include "drug resistance", "disease model", and "patient-derived tumor organoids".
    CONCLUSION: Research on hepatic organoids has increased over the past decade and is expected to continue to grow. Key research areas include applications for liver diseases and drug development. Future trends likely to gain focus include patient-derived tumour organoids, disease modelling, and personalized medicine.
    Keywords:  Bibliometric analysis; CiteSpace; Hepatic organoid; Three-dimensional culture; Web of Science Core Collection
    DOI:  https://doi.org/10.4254/wjh.v17.i2.95624
  23. Digit Health. 2025 Jan-Dec;11:11 20552076251323833
    The application of artificial intelligence in stroke research: A bibliometric analysis.
    Yun Peng, Zhen Zhao, Yutong Rao, Ke Sun, Jiayi Zou, Guanqing Liu.
       Background: Currently, artificial intelligence (AI) has been widely used for the prediction, diagnosis, evaluation and rehabilitation of stroke. However, the quantitative and qualitative description of this field is still lacking.
    Objective: This study aimed to summarize and elucidate the research status and changes in hotspots on the application of AI in stroke over the past 20 years through bibliometric analysis.
    Materials and Methods: Publications on the application of AI in stroke in the past two decades were retrieved from the Web of Science Core Collection. Microsoft Excel was used to analyze the annual publication volume. The cooperation network map among countries/regions was generated on an online platform (https://bibliometric.com/). CiteSpace was used to visualize the co-occurrence of institutions and analyze the timeline view of references and burst keywords. The network visualization map of keywords co-occurrence was generated by VOSviewer.
    Results: A total of 4437 publications were included. The annual number of published documents shows an upwards trend. The USA published the most documents and has the top 3 most productive institutions. Journal of Neuroengineering and Rehabilitation and Stroke are the journals with the most publications and citations, respectively. The keywords co-occurrence network classified the keywords into four themes, that is "rehabilitation," "machine learning," "recovery" and "upper limb function." The top 3 keywords with the strongest burst strength were "arm," "upper limb" and "therapy." The most recent keywords that burst after 2020 and last until 2023 included "scores," "machine learning," "natural language processing" and "atrial fibrillation."
    Conclusion: The USA shows a leading position in this field. At present and in the next few years, research in this field may focus on the prediction/rapid diagnosis of potential stroke patients by using machine learning, deep learning and natural language processing.
    Keywords:  Artificial intelligence; bibliometric; stroke
    DOI:  https://doi.org/10.1177/20552076251323833
  24. Glob Ment Health (Camb). 2025 ;12 e21
    Bibliometric analysis of OCD prevalence in youth populations of developing countries.
    Jacob Blaney, Sanjana Konda, Latha Ganti.
      This paper is a bibliometric analysis of research of adolescent obsessive-compulsive disorder (OCD) in developing nations. An analysis of 4,807 papers was conducted to show trends in these areas. The most significant research came from developed countries - with the United States and England having the most publications and the strongest citation strength. However, developing countries play an important role in the development of OCD research because of how they deliver different perspectives into the field given their more distant associations with developed nation's research. This study will use multiple indicators of bibliometrics, most notably bibliographic coupling and citation strength, to draw conclusions to show the various contributions of different nations to the field of adolescent OCD.
    Keywords:  Bibliometric analysis; Mental health; Obsessive Compulsive Disorder
    DOI:  https://doi.org/10.1017/gmh.2025.12
  25. Discov Oncol. 2025 Mar 03. 16(1): 262
    Global trends and emerging research in nanotechnology for esophageal cancer: a comprehensive bibliometric analysis.
    Chun-Jian Zuo, Jie Tian.
       BACKGROUND: Despite the growing body of research on nanotechnology for esophageal cancer (EC), a comprehensive bibliometric analysis in this field has yet to be conducted. This study aims to fill this gap by analyzing global research trends, key contributors, and emerging themes in nanotechnology for EC.
    METHODS: A bibliometric analysis was performed on publications from 1980 to 2024, using data from the Web of Science Core Collection. The analysis was conducted using VOSviewer, CiteSpace, and the R package 'bibliometrix' to visualize research trends, collaboration networks, and thematic areas.
    RESULTS: The analysis included 419 documents authored by 2952 researchers from 44 countries. A significant increase in publications was observed, particularly after 2011, with China, the United States, and Japan leading the contributions. Prominent institutions, including Zhengzhou University and the Chinese Academy of Sciences, were identified as key players. The research predominantly focused on drug delivery systems, nanomedicine, and cancer treatment mechanisms, with emerging trends in the development of advanced nanomaterials for personalized therapies.
    CONCLUSION: This comprehensive bibliometric analysis of nanotechnology applications in EC highlights global research trends, key contributors, and emerging research areas. The findings underscore the crucial role of nanotechnology in advancing treatment strategies for EC and identify areas for future research and interdisciplinary collaboration.
    Keywords:  Bibliometric analysis; Drug delivery systems; Emerging trends; Esophageal cancer; Nanotechnology
    DOI:  https://doi.org/10.1007/s12672-025-02018-z
  26. Front Surg. 2025 ;12 1552102
    Bibliometric analysis of the Top 1000 most-cited articles in otolaryngology over the past decade: global research trends and hotspots.
    Zhipeng Wang, Guodong Yu.
       Background: The field of otolaryngology has achieved remarkable progress over the past decade due to technological advancements and interdisciplinary integration. Understanding research trends and hotspots is essential to drive further innovation and development.
    Methods: A comprehensive search was conducted on Web of Science on November 22, 2024, to identify the top 1,000 most-cited otolaryngology publications from 2014 to 2024. Data were analyzed using GraphPad Prism v8.0.2, CiteSpace (6.2.4R), and VOSviewer (1.6.18) to visualize trends and research networks.
    Results: The annual publication volume in otolaryngology decreased after 2014, with the United States dominating in both publication count and citation frequency. Influential journals and prominent authors were identified, and research areas expanded beyond traditional clinical management to interdisciplinary fields. Chronic rhinosinusitis, olfactory dysfunction, and machine learning emerged as key research hotspots.
    Conclusion: Otolaryngology has made significant progress across multiple domains. Future research should focus on integrating artificial intelligence into clinical practice, fostering interdisciplinary collaborations, and advancing precision medicine and translational research. These efforts will be critical for addressing emerging challenges and capitalizing on new opportunities in the field.
    Keywords:  ENT; bibliometric analysis; discipline development; otolaryngology; review
    DOI:  https://doi.org/10.3389/fsurg.2025.1552102
  27. Eur Arch Paediatr Dent. 2025 Mar 05.
    Harmful oral habits in childhood: a global bibliometric analysis.
    K Cardoso, B B Souza, A O Rocha, C M Santana, M Bolan, M Cardoso.
       OBJECTIVE: Quantitative analysis of all articles on harmful oral habits through a bibliometric review.
    METHODOLOGY: The search was conducted on August 08, 2024 using the Web of Science database. All papers addressing the topic were included without language or date restrictions. Editorials, conferences, and meeting abstracts were excluded. From the selected articles, the following data were extracted: number of citations in Web of Science, year and journal of publication, impact factor (IF-2022), study design, type of deleterious habit and study objective, country, continent, institution, author, and keywords. Data analysis was performed using SSPS and VOSviewer software.
    RESULTS: 208 articles were included. Publications occurred between 1983 and 2024. The most cited article had 123 citations. The journals with the highest number of publications were the Journal of Clinical Pediatric Dentistry (n = 11) and the journal with the highest IF was the International Journal Oral Science (IF-14.9). There was observed a higher prevalence of observational study designs (n = 178), non-nutritive sucking habits (n = 151), and an association between harmful oral habits and malocclusion (n = 93). Most articles originated in the European continent (n = 77), the most prevalent country was Brazil (n = 61), with emphasis on the University of São Paulo (n = 8). The most frequent author was Paiva SM (n = 8).
    CONCLUSION: This global analysis reveals greater interest in occlusal damage and non-nutritive sucking habits. The participation of observational studies is more prevalent.
    Keywords:  Bibliometrics; Child; Habits; Sucking behaviour
    DOI:  https://doi.org/10.1007/s40368-024-00995-3
  28. Front Med (Lausanne). 2025 ;12 1505450
    Artificial intelligence and perinatology: a study on accelerated academic production- a bibliometric analysis.
    Ümran Kılınçdemir Turgut.
       Objective: The main purpose of this bibliometric study is to compile the rapidly increasing articles in the field of perinatology in recent years and to shed light on the research areas where studies are concentrated.
    Materials and methods: This bibliometric study was conducted using the Thomson ISI Web of Science Core Collection (WOSCC) system on May 4, 2024, with specific keywords. The abstracts of 1,124 articles that met the criteria were reviewed, and 382 articles related to perinatology were evaluated. Keyword co-occurrence, co-citation of authors, and co-citation of references analyses were conducted using VOSviewer (version 1.6.19). Out of these, 121 articles with 10 or more citations were analyzed in terms of their content and categorized under the headings "Purpose of Evaluation," "Medical Methods and Parameters Used," "Output To Be Evaluated," and "Fetal System or Region Being Evaluated."
    Results: In this bibliometric study, it was found that the most frequently published journal among the 382 examined articles was Medical Image Analysis, while the journals with the most publications in the field of perinatology were Prenatal Diagnosis and Ultrasound in Obstetrıcs & Gynecology. The most commonly used keyword was "deep learning" (115/382). Among the 121 highly cited articles, the most common purpose of evaluation was "Prenatal Screening." Artificial intelligence was most frequently used in ultrasound (59.8%) imaging, with MRI (20.5%) in second place. Among the evaluated outputs, "organ scanning" (35/121) was in first place, while "biometry" (34/121) was in second place. In terms of evaluated systems and organs, "growth screening" (35/121) was the most common, followed by the "neurological system" (33/121) and then the "cardiovascular system" (18/121).
    Conclusion: I has witnessed the increasing influence of artificial intelligence in the field of perinatology in recent years. This impact may mark the historic beginning of the transition to the AI era in perinatology. Milestones are being laid on the path from prenatal screening to prenatal treatment.
    Keywords:  artificial intelligence; bibliometric analysis; deep learning; fetal imaging techniques; machine learning; perinatology
    DOI:  https://doi.org/10.3389/fmed.2025.1505450
  29. World J Hepatol. 2025 Feb 27. 17(2): 102001
    Immunological landscape of hepatic alveolar echinococcosis: A bibliometric analysis.
    Aliya Tulading, Jing Wu, Yun-Fei Zhang, Alimujiang Mamuti, Yilizhati Azhati, Chun-Hui Lv, Abudusalamu Tuersunmaimaiti, Tuerhongjiang Tuxun.
       BACKGROUND: Hepatic alveolar echinococcosis (HAE) is a chronic parasitic disease caused by the larval stage of Echinococcus multilocularis. Although significant research has been conducted on the pathogenesis and immunological aspects of HAE, comprehensive bibliometric analyses in this area are still lacking. This study sought to fill this gap by systematically analyzing the immunological literature on HAE using bibliometric methods.
    AIM: To identify research trends, key contributors, and emerging developments and offer insights to guide future research in this field.
    METHODS: Research articles on HAE published between 1983 and 2023 were retrieved from the Web of Science Core Collection database. A total of 319 articles were selected for bibliometric analysis, which was conducted using the CiteSpace and VOSviewer software. The analysis focused on key variables such as publication volume, authors, journals, countries, references, and keywords.
    RESULTS: The analysis revealed a significant increase in research on HAE over the past four decades, particularly after 1995. China and Switzerland emerged as the leading countries in terms of publication volume, with Bruno Gottstein and Vuitton DA identified as the most influential authors in this field. Key research areas include the interaction between the pathogen and the host immune system, as well as advances in disease diagnosis and treatment strategies. The keyword co-occurrence analysis highlighted the primary themes and identified emerging trends within the research landscape.
    CONCLUSION: This study provides a comprehensive framework for understanding HAE immunology and highlights research hotspots, future directions, key contributors, and the importance of international cooperation.
    Keywords:  Bibliometrics; CiteSpace; Hepatic alveolar echinococcosis; Immune; Visualization; Vosviewer
    DOI:  https://doi.org/10.4254/wjh.v17.i2.102001
  30. Front Oncol. 2025 ;15 1443890
    Global research prospects and trends in TFH cells and tumors: a bibliometric analysis.
    Hao Lei, Jin Hu, Junpeng Zhu, Runze Li, Yu Zhao, Yaqi Zhao, Guisheng He, Tao Song, Chong Lu, Wuping Zheng, Lei Li, Chunping Liu, Hengyu Chen.
       Background: T follicular helper (TFH) cells, a subset of CD4+Th cells, play a critical role in B cell activation, proliferation, and differentiation primarily within B follicles in secondary lymphoid organs, essential processes for effective antibody responses. TFH cells are also implicated in various conditions, including autoimmune diseases, cancer, infectious diseases, allergies, and vaccine reactions. Despite their broad impact, a review of the literature on TFH cells and tumors has not been conducted. We aimed to fill this gap by providing a detailed analysis of the research landscape concerning TFH cells and tumors.
    Method: We conducted a bibliometric analysis of literature on TFH cells and tumors from 2012 to 2024 using the Web of Science Core Collection (WoSCC). For an analysis of the global research landscape, we employed VOSviewer (version 1.6.20), CiteSpace 6.2.R6 software, and the "bibliometric" package in R language (version 4.3.2) to evaluate data on countries/regions, authors and cited authors, institutions, journals, references, and keywords. We also conducted a systematic review to summarize the global research trends, prospects, and hotspots in this field.
    Results: Our analysis included contributions from 60 countries/regions, 7,864 authors, 35,853 cited authors, 1,756 institutions, 385 academic journals, 50883 references, 222 keywords, and 1,181published papers. Over the past decade, the volume of research on TFH cells and tumors had consistently increased. China published the most papers, more than double that of the United States. The top 2 authors ranked by publication volume were Gaulard, Philippe (14 articles, 379 citations), and De leval, Laurence (12 articles, 236 citations) Notably, 9 of the top 10 most published institutions were from China. Frontiers in Immunology and Immunity were the leading journals in publications and citations. A cluster analysis revealed a shift in research focus from "expression","B cells" and "survival" to "tumor microenvironment", "tumor infiltrating immune cells" and "immune infiltration" in recent years.
    Conclusion: This bibliometric analysis suggests that TFH cells hold significant research value and potential clinical applications in tumor immunotherapy. Moreover, the bibliometric analysis offers valuable references and guidance for related research endeavors. It also points out the prevailing issues and challenges in TFH cell research, and underscores the need for further basic and clinical research to advance the related fields.
    Keywords:  CD4+Th cells; Tfh cells; bibliometrics; immune; tumor
    DOI:  https://doi.org/10.3389/fonc.2025.1443890
  31. J Formos Med Assoc. 2025 Mar 02. pii: S0929-6646(25)00093-2. [Epub ahead of print]
    A bibliometric analysis of primary health care publication trends in the Asia-Pacific region from 2011 to 2023.
    Chun-Feng Huang, Brian Bih-Jeng Chang, I-Hsuan Hwang, Yu-Chun Chen, Shinn-Jang Hwang.
       BACKGROUND: Emphasis on primary health care (PHC) is the most efficient and economical approach to achieving universal health coverage, and should serve as its foundation. The aim of the study is to examine academic publications from 2011 to 2023 in the Asia-Pacific region (APR) using the Web of Science (WoS) subject category of PHC.
    METHODS: Academic papers in the WoS PHC category published in the APR from 2011 to 2023 were retrieved and analyzed, including papers published in the Science Citation Index-Expanded and the Social Science Citation Index.
    RESULTS: A total of 5172 papers were published in the WoS PHC category from APR onwards. The annual number of publications and their citations increased from 2011 to 2023. Australia led PHC publications in the APR with 3918 publications (75.75% of APR regional output). New Zealand had the highest number of citations per paper (14.54) and the highest mean impact factor (3.25 ± 1.70). Publications in the WoS PHC category also covered a wide range of topics, including Medicine General Internal (70.86%), Health Care Sciences Services (18.10%), Health Policy Services (17.67%), and Public Environmental Occupational Health (17.67%), demonstrating the breadth of PHC research.
    CONCLUSION: The annual number of publications and their citations in the WoS PHC category from the APR increased from 2011 to 2023. Australia and New Zealand have a significant presence in the PHC publications in the APR.
    Keywords:  Bibliography; Family medicine; General practitioners; Primary health care; Subject category; Web of science
    DOI:  https://doi.org/10.1016/j.jfma.2025.02.028
  32. J Multidiscip Healthc. 2025 ;18 1107-1121
    Exploring Research Trends and Mechanisms: Maternal Diabetes and Neural Tube Defects (1991-2023).
    Lijun Cao, Yujia Xi, Zhinan Jing, Zhuocheng Bao, Bo Bai, Xia Lian, Xiuping Zhang, Jingkai Di, Fan Liu.
       Background: Neural tube defect (NTD) is the second most common congenital neuropathy in the world. Maternal diabetes is an important factor leading to the occurrence of NTD in offspring. However, existing studies lack a systematic analysis of the correlation between maternal diabetes and NTDs, as well as an exploration of NTD pathogenesis and associated preventive strategies. Consequently, there is a need for a thorough examination of the literature pertaining to NTDs and maternal diabetes to elucidate a comprehensive understanding, identify research focal points, and anticipate future developmental trends.
    Methods: The literature related to NTDs and maternal diabetes from 1991 to 2023 was retrieved from the Web of Science Core Collection (WoSCC). Bibliometric software CiteSpace (version 6.2.6) was used for co-occurrence/citation network analysis and to draw a knowledge visualization map.
    Results: A total of 382 articles and reviews were included in the final analysis. Findings revealed an increasing trend in annual publication rates. The University of Maryland Baltimore emerged as the institution with the highest number of publications, while the American Journal of Obstetrics and Gynecology and Birth Defects Research Part A-Clinical and Molecular Teratology stood out as the most prolific research journals. EA Reece was identified as the leading contributor in this domain. The United States emerged as the global leader in this field, making the most significant contribution to research endeavors. The cluster analysis of keywords obtained eight clusters, and the research focus was on the pathogenesis of NTDs induced by maternal diabetes.
    Conclusion: This study employed bibliometric methods to visualize the research landscape of NTDs induced by maternal diabetes, aiming to comprehend trends and identify key areas of interest in this domain. By studying the relevant mechanisms, we will search for new key targets. Meanwhile, future research needs to further explore new treatment strategies.
    Keywords:  CiteSpace; VOSviewer; bibliometric analysis; cluster analyses; diabetes; neural tube defects; research hotspots; visualization
    DOI:  https://doi.org/10.2147/JMDH.S501402
  33. J Liq Biopsy. 2024 Sep;5 100158
    Global research trends in liquid biopsy for ovarian cancer from 1999 to 2023: A 25-year bibliometric analysis.
    Jixian Wan, Zechuan Rao, Huaichao Liu, Jipeng Wan.
       Background: Ovarian cancer (OC) is a major cause of gynecological cancer-related death in the world. Liquid biopsy has shown great potential in improving the ovarian cancer detection and treatment. The aim of this study is to explore the previous studies, current hotspots, and future trends of liquid biopsy for OC from a bibliometric perspective.
    Methods: Articles on liquid biopsy in the field of OC were collected from Web of Science (Clarivate Analytics). Subsequently, bibliometric and visual analyses was conducted using bibliometrix, VOSviewer, CiteSpace, and Microsoft Excel.
    Results: A total of 504 scientific papers were retrieved over a 25-year period, of which 285 papers were in the language of English. China has the highest number and other papers came from 41 countries or regions. The journal with the highest publication count was Cancers. There were 2013 authors in total, and Kasimir-Bauer S emerged as the most productive author. The key words that are still exploding are recurrence, predictive value and survival.
    Conclusion: Research on liquid biopsy is booming in the field of OC. This article comprehensively elucidates the subject matter over recent years, and points out emerging trends for in-depth exploration.
    Keywords:  Bibliometric analysis; Circulating tumor DNA; Circulating tumor cells; Exosomes; Liquid biopsy; Ovarian cancer
    DOI:  https://doi.org/10.1016/j.jlb.2024.100158
  34. Front Med (Lausanne). 2025 ;12 1472637
    Visual analysis of emerging topics and trends in contrast agent extravasation research in medical imaging: a bibliometric study using CiteSpace and VOSviewer.
    Yun Liu, Yonghai Dong, Wenfang Zhou, Juhong Yu.
       Purpose: This study presents a visualization of the global research dynamics on contrast agent extravasation in medical imaging using a knowledge map, revealing the research directions, emerging topics, trends, and frontiers in this field.
    Method: Using CiteSpace and VOSviewer software with the Web of Science Core Collection database as the data source, a bibliometric analysis was conducted on relevant studies of contrast agent extravasation in medical imaging examinations. Analysis was performed on aspects such as yearly publication volume, country/institution distribution, authorship, co-citation documents, and keywords, leading to the creation of visualizations.
    Results: A total of 4,635 articles were included in the study, with the first relevant research report appearing in 1950. The yearly publication and citation volumes have shown an overall increasing trend over the years. Research in this field was predominantly concentrated in the United States, accounting for approximately one-third of the global publication output. The University of California System was the top institution in terms of publication volume. The top five high-frequency keywords were "magnetic resonance imaging," "computed tomography," "management," "diagnosis," and "contrast agent." Cluster analysis of keywords revealed three main clusters: "contrast," "fluorescein angiography," and "focused ultrasound," showing good continuity over time. The keyword burst analysis identified that "gd dtpa" had the highest burst value of 20.51. The emergence of keywords shifted over time. At present, the keywords that are still emerging are "multimodal imaging," "case report," and "leakage."
    Conclusion: More scholars are dedicating efforts to research on contrast agent extravasation in medical imaging. "Multimodal imaging" will be a key research focus in the foreseeable future. Contrast agent extravasation remains a substantial challenge with high research value in medical imaging.
    Keywords:  CiteSpace; VOSviewer; contrast agent; extravasation; imaging; visual analysis
    DOI:  https://doi.org/10.3389/fmed.2025.1472637
  35. Int J Surg. 2025 Mar 06.
    Comments on "worldwide research trends on tumor burden and immunotherapy: a bibliometric analysis".
    Guangtao Han, Lijun Cai, Qin Wang, Shuo Sun, Pengde Kang.
      
    DOI:  https://doi.org/10.1097/JS9.0000000000001504
  36. BMC Psychiatry. 2025 Mar 01. 25(1): 186
    Quantitative analysis of literature on diagnostic biomarkers of Schizophrenia: revealing research hotspots and future prospects.
    Liuyin Jin, Linman Wu, Jing Zhang, Wenxin Jia, Han Zhou, Shulan Jiang, Pengju Jiang, Yingfang Li, Yang Li.
       BACKGROUND: Schizophrenia (SCZ) is a complex mental disorder characterized by a wide range of symptoms and cognitive impairments. The search for reliable biomarkers for SCZ has gained increasing attention in recent years, as they hold the potential to improve early diagnosis and intervention strategies. To understand the research trends and collaborations in this field, a comprehensive Bibliometric analysis of SCZ and biomarkers research was conducted.
    METHODS: A systematic search of the Web of Science Core Collection was performed to retrieve relevant articles published from January 2000 to July 2023. The search focused on SCZ and biomarkers. Bibliometric tools, including CiteSpace, VOSviewer, and R package Bibliometrix, were utilized to perform data extraction, quantitative analysis, and visualization.
    RESULTS: The search focused on SCZ and biomarkers, and a total of 2935 articles were included in the analysis. The analysis revealed a gradual increase in the number of publications related to SCZ and biomarkers over the years, indicating a growing research focus in this area. Collaboration and research activity were found to be concentrated in the United States and Western European countries. Among the top ten most active journals, "Schizophrenia Research" emerged as the journal with the highest number of publications and citations related to SCZ and biomarkers. Recent studies published in this journal have highlighted the potential use of facial expressions as a diagnostic biomarker for SCZ, suggesting that facial expression analysis using big data may hold promise for future diagnosis and interventions. Furthermore, the analysis of key research keywords identified inflammatory factors, DNA methylation changes, and glutamate alterations as potential biomarkers for SCZ diagnosis.
    CONCLUSION: This Bibliometric analysis provides valuable insights into the current state of research on SCZ and biomarkers. The identification of reliable biomarkers for SCZ could have significant implications for early diagnosis and interventions, potentially leading to improved outcomes for individuals affected by this challenging mental disorder. Further research and collaborations in this field are encouraged to advance our understanding of SCZ and enhance diagnostic and therapeutic approaches.
    Keywords:  Bibliometrics; Biomarkers; CiteSpace; SCZ; VOSviewer
    DOI:  https://doi.org/10.1186/s12888-025-06644-3
  37. Front Pediatr. 2025 ;13 1463294
    Tandem mass spectrometry in screening for inborn errors of metabolism: comprehensive bibliometric analysis.
    Victoria Kononets, Gulmira Zharmakhanova, Saule Balmagambetova, Lyazzat Syrlybayeva, Gulshara Berdesheva, Zhanna Zhussupova, Aidana Tautanova, Yergen Kurmambayev.
      Tandem mass spectrometry (MS/MS) for detection of inborn errors of metabolism (IEM) is recognized as an ethical, safe, simple, and reliable screening test. Presented bibliometric analysis aims to describe the network structure of the scientific community in the study area at the level of countries, institutions, authors, papers, keywords, and sources; scientific productivity, directions, and collaboration efforts in a considered period (1991-2024, May). Using the PRISMA method, we conducted a systematic search for articles reporting using MS/MS to screen for inherited metabolic disorders and inborn errors of metabolism collected from the Web of Science Core Collection (WoSCC). A total of 677 articles out of 826, by 3,714 authors, published in 245 journals, with 21,193 citations in 11,295 citing articles, with an average citation of 31.3 per article, and an H-index of 69 were retrieved from the WoSCC. The research status of MS/MS in IEM screening was identified. The most relevant current research directions and future areas of interest were revealed: "selective screening for IEM," "new treatments for IEM," "new disorders considered for MS/MS testing," "ethical issues associated with newborn screening," "new technologies that may be used for newborn screening," and "use of a combination of MS/MS and gene sequencing".
    Keywords:  bibliometric analysis; inborn errors of metabolism; newborn screening; scientometrics; selective screening; tandem mass spectrometry; visualization
    DOI:  https://doi.org/10.3389/fped.2025.1463294
  38. JAAPA. 2025 Mar 07.
    Examining gender trends in PA authorship: A retrospective analysis of JAAPA and JPAE.
    Sara Lolar, Robert R Ehrman, Anne M Messman, Alexandria Garino.
       OBJECTIVE: This study benchmarked gender trends in research authorship in the physician associate (PA) profession.
    METHODS: A bibliometric analysis was conducted of the Journal of Physician Assistant Education and the Journal of the American Academy of Physician Associates from January 2014 to September 2022. We collected data on instances of PA first, last, and solo authorship of clinical or research articles. Author gender was verified through professional websites. Simple proportions and the Mann-Kendall test are reported.
    RESULTS: Among 1,315 collected instances of PA authorship, women represented 65.6% (n = 863) of the population, comprising 67.8% of first authors and 60.7% of last authors. The proportion of authors categorized as women increased over time (P = .04). Women were more likely to have only one publication compared with men.
    CONCLUSIONS: Although positive signs of increased research authorship by women are evident, women still lag behind men in overall publication numbers and in senior authorship roles compared with their representation in the PA profession.
    DOI:  https://doi.org/10.1097/01.JAA.0000000000000095
  39. Ann Afr Med. 2025 Mar 03.
    Trends and Insights in Cognitive Impairment and Depression Research: A Comprehensive Bibliometric Analysis.
    Feras Alsulaiman, Majed Alabdali, Danah Aljaafari, Arwa A Alsulaiman, Safa I Alzahrani, Rawan M Alyahya, Mohammed Alshurem, Abdulla Alsulaiman, Omar Al Ghamdi.
       INTRODUCTION: Cognitive impairment and depression are widespread, debilitating conditions that significantly impact quality of life and present major public health challenges. This study aimed to explore the intersection of cognitive impairment and depression, identifying trends, major contributors, influential studies, and emerging research subjects.
    METHODS: We conducted a bibliometric analysis using the Scopus database on July 21, 2024, covering the literature from 2000 to 2024. Data were extracted and analyzed using R (version 4.3.3) with the bibliometrix package and "biblioshiny" web interface for visualization. The analysis included assessing publication trends, identifying the leading authors, evaluating major journals, and tracking institutional contributions. Keyword co-occurrence and thematic tracking were used to explore the research focus subjects and evolving trends.
    RESULTS: Two thousand and fifty-one articles were identified, with annual scientific production showing a 7.71% growth rate, from 18 articles in 2000 to 195 articles in 2022. The average number of citations per article fluctuated, previously increasing but declining in recent years. The leading journals included the Journal of Affective Disorders and the American Journal of Geriatric Psychiatry. The leading authors were Zhang Y and Li Y, with significant contributions from the University of Toronto and the University of California. The USA led in article production, followed by China and Canada, with extensive international collaboration. The most cited document was that of Rock etal.,with 1336 citations. The keyword analysis highlighted "depression" as the most frequent term, and thematic tracking revealed distinct clusters of nonhuman and human research.
    DISCUSSION: This study's results inform future research guidelines and underscore the importance of interdisciplinary collaboration to address these interrelated conditions. It contributes to the existing literature by tracking the evolution and current state of research and guiding future studies toward emerging themes and gaps in this faculty.
    DOI:  https://doi.org/10.4103/aam.aam_258_24
  40. Front Psychol. 2025 ;16 1450497
    Bibliometric analysis of global research on dialectical behavior therapy from 1987 to 2024.
    Kuo Shi, Li-Yi Zhang, Bing-Ling Gao, Ying Qian, Xue-Bing Huang, Jing-Li Yue.
       Objective: This study explores researches of dialectical behavior therapy (DBT) in mental health to provide an overview of current knowledge landscape and predict future development trends of DBT.
    Method: The bibliometric approach was used in the study. Articles on DBT-related research were retrieved from the Web of Science Core Collection (WoSCC) database up to December 31, 2024, and analyzed using VOSviewer and CiteSpace.
    Results: A total of 2,723 articles were analyzed. DBT research has grown significantly since the 1990s, with the United States leading in publication volume, citation impact, and academic collaboration. Research is primarily conducted in developed countries like the United States, the United Kingdom, and Germany, with limited contributions from emerging economies. Cognitive and Behavioral Practice is the most prolific journal in DBT research. Key topics include borderline personality disorder (BPD), suicide, adolescent interventions, forensic psychiatry, and family therapy. Recently, keywords such as "emotion dysregulation" and "mobile phone" have become research hotspots.
    Conclusion: DBT research has evolved from early focus areas like BPD and suicide to studies on emotion dysregulation mechanisms and digital interventions. While the United States dominates the field, expanding participation from emerging countries and strengthening global collaboration could advance DBT research and improve mental health accessibility. This bibliometric analysis provides a global perspective and long-term trend insights, highlighting future directions in neurobiological mechanisms, methodological innovation, and technological integration.
    Keywords:  Bibliometrics; DBT; behavior therapy; global; visualization
    DOI:  https://doi.org/10.3389/fpsyg.2025.1450497
  41. Front Oncol. 2025 ;15 1466818
    Prognostic factors and outcomes in pediatric acute myeloid leukemia: a comprehensive bibliometric analysis of global research trends.
    Mingliang Rao, Wenna Luo, Caiju Luo, Baojing Wu, Tiantian Xu, Ziqian Wei, Haolan Deng, Kejing Li, Dunhua Zhou.
       Background: Pediatric AML prognosis research has advanced significantly, yet gaps in understanding genetic and molecular interactions persist. Despite improved outcomes, relapse/refractory cases and personalized treatment integration remain critical clinical challenges.
    Objective: To analyze the global research landscape on pediatric AML prognosis, highlight influential components and collaborations, and identify major potential research trends.
    Methods: Publications on pediatric AML prognosis research from 1999 to 2023 were retrieved from the Clarivate Analytics Web of Science Core Collection (WoSCC) database. Bibliometric analysis was conducted using CiteSpace and VOSviewer to identify leading countries, prominent institutions, high-impact journals, key research categories, influential authors, and emerging research topics.
    Results: The bibliometric analysis encompassed 924 publications, with St. Jude Children's Research Hospital emerging as the most prolific institution. The United States leads globally in terms of countries, institutions, journals, and authors. Todd A. Alonzo ranks highest in publication volume, while U. Creutzig leads in citations. The top research categories were Oncology, Hematology, and Pediatrics. Key research topics included genomics, transcriptomics, epigenomics, targeted therapies, immune therapy, and integrative diagnostic approaches.
    Conclusion: This bibliometric analysis highlights significant advancements in pediatric AML prognosis over the past 25 years, driven by the integration of genetic markers, immunological insights, transcriptomics, and epigenomics, which have collectively transformed risk stratification and treatment strategies. Overcoming challenges, such as discovering new therapeutic targets and enhancing treatment combinations, will depend on global collaboration and advanced technologies to propel the field forward.
    Keywords:  bibliometric analysis; genetic markers; immune therapy; pediatric AML; prognosis
    DOI:  https://doi.org/10.3389/fonc.2025.1466818
  42. J Voice. 2025 Feb 28. pii: S0892-1997(25)00030-X. [Epub ahead of print]
    Laryngeal Dystonia: A Global Retrospective Study Through Bibliometric Analysis.
    Yuanjia Hu, Lu Xing, Peiyun Zhuang.
       OBJECTIVES: This study aims to comprehensively analyze global research trends and developments in laryngeal dystonia (LD), providing valuable insights into the current state of LD research and highlighting emerging areas for future investigation, with particular focus on the role of novel technologies and interdisciplinary collaborations.
    METHODS: We conducted a bibliometric analysis of 497 studies on LD retrieved from PubMed, CINAHL, Embase, Scopus, and Web of Science, spanning from 1971 to 2023. Utilizing R, VOSviewer, and Citespace, we examined the characteristics and trends of the accumulated scientific literature, aiming to offer comprehensive insights and directions for future research.
    RESULTS: The analysis revealed substantial growth in publications, with significant contributions from 1555 authors across 120 journals. The United States, Japan, and Canada were the leading contributors. Notably, 44.5% of the studies appeared in four core journals, including the Journal of Voice. Research was largely supported by 372 grants, predominantly from the National Institutes of Health (USA). Emerging research areas include treatments for LD, assessment tools, and innovative fields such as artificial intelligence (AI), cortical silent periods (CSP), and deep brain stimulation (DBS).
    CONCLUSIONS: Despite the growing research interest in LD, substantial breakthroughs remain scarce. Collaborative international efforts are essential to drive innovative advancements in LD research, particularly by leveraging new technologies such as AI, to sustain and accelerate development in this evolving field.
    Keywords:  Laryngeal dystonia—Bibliometric—Hotspots—Trends
    DOI:  https://doi.org/10.1016/j.jvoice.2025.01.029
  43. Saudi J Gastroenterol. 2025 Mar 03.
    A bibliometric analysis of a decade's research on metabolic dysfunction-associated steatotic liver disease in the Arab world.
    Waleed Alhazzani, Shadan AlMuhaidib, Haifa F Alotaibi, Waleed S Alomaim, Rawan Alqahtani, Faisal M Sanai, Faisal Abaalkhail, Saleh A Alqahtani.
       BACKGROUND: Metabolic dysfunction-associated steatotic liver disease (MASLD) presents a significant global health challenge, with the Arab region exhibiting a markedly higher prevalence. We aim to evaluate MASLD research output, collaboration patterns, and funding impact in the Arab region over the last decade.
    METHODS: We conducted a bibliometric analysis of MASLD research in 22 Arab countries (2014-2023) using Clarivate Analytics' InCites. Data on MASLD prevalence were extracted from the Global Burden of Disease, while population and economic data from the World Bank. We assessed MASLD-related publications, prevalence, collaboration patterns, and citation and funding impact.
    RESULTS: Between 2014 and 2023, Arab countries contributed 844 publications (3.3% of global MASLD research). We identified positive correlations between MASLD-related publications and gross domestic product (GDP) (rs = 0.825, P < 0.001), age-standardized prevalence (rs = 0.627, P = 0.002), and population size (rs = 0.509, P = 0.016). International collaborations accounted for 48.7% of these publications, with a citation impact of 15.7 compared to the global average of 23.7. Arab-funded MASLD-related publications constituted 19.4% of MASLD publications in the Arab world versus 42.3% globally funded. Citation impacts were similar between Arab-funded (30.6) and globally funded publications (30.3). Of the top 10 countries globally with the highest GDP, 47.8% of the MASLD publications received funding, yielding a citation impact of 33.5.
    CONCLUSION: Despite the high MASLD prevalence, Arab countries exhibit lower research output, impact, and funding compared to global levels. Increased regional collaboration and investment in MASLD research are critical to addressing this disparity.
    DOI:  https://doi.org/10.4103/sjg.sjg_431_24
  44. Digit Health. 2025 Jan-Dec;11:11 20552076251324456
    The application of artificial intelligence in insomnia, anxiety, and depression: A bibliometric analysis.
    Enshi Lu, Di Zhang, Mingguang Han, Shihua Wang, Liyun He.
       Background: Mental health issues like insomnia, anxiety, and depression have increased significantly. Artificial intelligence (AI) has shown promise in diagnosing and providing personalized treatment.
    Objective: This study aims to systematically review the application of AI in addressing insomnia, anxiety, and depression, identifying key research hotspots, and forecasting future trends through bibliometric analysis.
    Methods: We analyzed a total of 875 articles from the Web of Science Core Collection (2000-2024) using bibliometric tools such as VOSviewer and CiteSpace. These tools were used to map research trends, highlight international collaboration, and examine the contributions of leading countries, institutions, and authors in the field.
    Results: The United States and China lead the field in terms of research output and collaborations. Key research areas include "neural networks," "machine learning," "deep learning," and "human-robot interaction," particularly in relation to personalized treatment approaches. However, challenges around data privacy, ethical concerns, and the interpretability of AI models need to be addressed.
    Conclusions: This study highlights the growing role of AI in mental health research and identifies future priorities, such as improving data quality, addressing ethical challenges, and integrating AI more seamlessly into clinical practice. These advancements will be crucial in addressing the global mental health crisis.
    Keywords:  Artificial intelligence; anxiety; bibliometrics; depression; insomnia; mental health
    DOI:  https://doi.org/10.1177/20552076251324456
  45. Front Plant Sci. 2025 ;16 1530629
    Analysis of research status and trends on nano-agricultural application: a bibliometric study.
    Xing Luo, Jing Li, Song Guo, Hua Yu, Xiangzhong Zeng, Zijun Zhou, Yuxian Shangguan, Mingjiang He, Yiting Ouyang, Kun Chen, Zhimin Chen, Yusheng Qin.
       Introduction: The rapid global population growth and limitations of traditional agricultural practices have resulted in inadequate nutrient supply. Nano-agricultural technology presents significant potential for enhancing crop growth and resistance, reducing stresses, and providing economic benefits with lower environmental risks.
    Methods: In this study, a bibliometric analysis of nano-agricultural applications was conducted using the Web of Science Core Collection, and 2,626 publications from 2000 to 2023 were identified, with an exponential increase in both publications and citations.
    Results and discussion: European and Asian countries and institutions are more actively involved, although USA produces the highest-quality papers. Additionally, this field has evolved through two stages: the first stage (2000-2016) focused on the toxicology of nanomaterials (NMs), while the second stage (2017-present) emphasizes NMs as nanofertilizers to promote crop growth, and as nanoregulators or nanopesticides to enhance crop resistance against biotic stress and abiotic stress. Finally, future research perspectives were also proposed, including the optimalizations of NMs, the investigations of the behavior and bioavailability of NMs driven by rhizosphere and phyllosphere process, interdisciplinary collaboration across various fields, the application of NMs from laboratory to the field, and the long-term environmental behaviors and assessments of NMs in diverse ecosystems. Overall, this bibliometric study provides a valuable reference for understanding the development of this field and pinpointing research frontiers.
    Keywords:  bibliometric analysis; crops resistance; nanomaterials; phyllosphere process; sustainable agriculture
    DOI:  https://doi.org/10.3389/fpls.2025.1530629
  46. Vet Parasitol. 2025 Feb 27. pii: S0304-4017(25)00049-4. [Epub ahead of print]335 110438
    Global research landscape and trends in Toxoplasma gondii from 2003 to 2022: A bibliometric analysis.
    Shi-Jie Fan, Ming Pan, Chen-Yang Xia, Pin Yang, Si-Yang Huang.
      Toxoplasmosis is a globally prevalent zoonotic disease with significant public health impact, yet effective prevention and control measures remain lacking. This study analyzed 10,737 publications from 2003 to 2022 in the Web of Science and Scopus databases using bibliometric methods. Key metrics, including annual publication trends, journals, core authors, contributing countries, citations, and keywords, were examined. The findings indicate that publication output in toxoplasmosis research has remained stable, with core journals predominantly in the parasitology field. The United States leads in research capacity and contributions, followed by Brazil, Germany, the United Kingdom, and France, while China shows promising potential. Epidemiological research has been a longstanding hotspot in this field, encompassing areas such as diagnosis, prevention, treatment, virulence analysis, and genotyping. The field is expanding towards mechanistic research and translational applications, shifting its emphasis from basic science to practical public health applications and disease prevention strategies. Current research frontiers and emerging trends focus on host-pathogen interactions, innovative prevention and control methods, and the global public health implications of toxoplasmosis. This study provides a comprehensive overview of the past two decades of progress in toxoplasmosis research, offering valuable insights for future studies and academic development.
    Keywords:  Bibliometrics; CiteSpace; Hotpot; Scimago Graphica; Scopus; T. gondii; VOSviewer
    DOI:  https://doi.org/10.1016/j.vetpar.2025.110438
  47. Front Microbiol. 2025 ;16 1546852
    Phosphate-solubilizing microorganisms for soil health and ecosystem sustainability: a forty-year scientometric analysis (1984-2024).
    Yiming Lei, Yuhan Kuai, Mingyu Guo, Huan Zhang, Yuan Yuan, Hualong Hong.
      Phosphate-solubilizing microorganisms (PSM) play a crucial role in promoting crop growth by enhancing phosphorus supply and reducing phosphorus loss in soil. However, a comprehensive bibliometric overview of the research landscape on PSM in agricultural applications has been lacking. This study conducts a bibliometric analysis to explore global research trends, key contributors, and collaborative networks in the application of PSM in ecological restoration, providing valuable insights for future research. A total of 1,662 documents from the Web of Science Core Collection, spanning from 1984 to 2024, were extracted and analyzed using Bibliometrix and CiteSpace software. The findings reveal a period of rapid growth in this field since 2018. Initially, research focused on microbial soil nutrients, such as phosphate rock and Azospirillum brasilense. Current research hotspots have shifted towards topics like drought and salt stress, as well as productivity, reflecting an increasing emphasis on mitigating the impacts of global warming and environmental changes. China and India lead in research output, contributing 36.67% of the total articles. The Indian Council of Agricultural Research published the highest number of articles. Future research on PSM should emphasize their role in enhancing nutrient uptake, improving soil health, and mitigating environmental stresses, supporting sustainable agriculture and ecological restoration. This bibliometric analysis of 1,162 articles by 7,454 authors from 101 countries highlights critical advances at the intersection of soil microbiology, sustainable land management, and climate change adaptation. These findings provide a foundation for addressing global challenges like soil degradation, nutrient cycling, and food security, aligning with the Sustainable Development Goals.
    Keywords:  crop growth; ecological restoration; global research trends; microbial soil nutrients; phosphorus availability; sustainable agriculture
    DOI:  https://doi.org/10.3389/fmicb.2025.1546852
  48. J Conserv Dent Endod. 2025 Feb;28(2): 126-131
    The trend of publications in the Journal of Conservative Dentistry and Endodontics: A 6-year systematic survey of the journal.
    Muhammad Hamdan, Ganesh Ranganath Jadhav, Prerna Verma.
       Objectives: The Journal of Conservative Dentistry and Endodontics (JCDE) is an English-language journal published by the Indian Association of Conservative Dentistry and Endodontics. It was indexed in PubMed in 2010 in periodical publications. The purpose of this paper was to review and analyze the publications in JCDE over the 6 years from 2019 to 2024.
    Materials and Methods: This article evaluated the subject, number, and type of articles published, key topics addressed, authorship patterns, and article citations of the JCDE over the last 6-year period.
    Results: A total of 750 papers were found, and the publication output peaked in 2024 when 133 articles were published. On average, each volume had 1.5 times as many publications on endodontic topics compared to restorative topics. An average of eleven articles per volume addressed multidisciplinary or other dental disciplines. Original research articles followed by literature reviews and case reports/series accounted for the most articles per volume. The most of the authors were from India followed by the Middle East, America, and other Asian countries. With about 2802 citations, the 2019 issue had the most citations. Esthetic Dentistry was the main topic in the top 10 most cited articles. JCDE has the 7th-highest h5-index across both endodontic and operative dentistry journals.
    Conclusions: Many manuscripts in endodontics, dental materials, restorative dentistry, and a few other pertinent specializations have been published in JCDE over the past 6 years.
    Keywords:  Bibliometrics; Journal of Conservative Dentistry and Endodontics; citation; publications; research
    DOI:  https://doi.org/10.4103/JCDE.JCDE_809_24
  49. Discov Oncol. 2025 Mar 06. 16(1): 269
    Global trends and research hotspots in nanodrug delivery systems for breast cancer therapy: a bibliometric analysis (2013-2023).
    Yang Li, Pingping Liu, Bo Zhang, Juan Chen, Yuanyuan Yan.
       OBJECTIVE: Nanomedicine offers fresh approaches for breast cancer treatment, countering traditional limitations. The nanodrug delivery system's precision and biocompatibility hold promise, yet integration hurdles remain. This study reviews nano delivery systems in breast cancer therapy from 2013 to 2023, guiding future research directions.
    METHODS: In this study, we conducted a comprehensive search on Web of Science database (Guilin Medical University purchase edition) and downloaded literature related to the field published between 2013 and 2023. We analyzed these publications using R software, VOSviewer, and CiteSpace software.
    RESULTS: This study reviewed 2632 documents, showing a steady publication increase from 2013 to 2023, peaking at 408 in 2022. China, USA, India, and Iran were prominent in publishing. The Chinese Academy of Sciences and Tabriz University of Medical Science were key collaboration centers. Notably, the Journal of Controlled Release and Biomaterials ranked among the top 10 journals for publications and citations, establishing their field representation. Key terms like "breast cancer," "nanoparticles," "drug delivery," "in-vitro," and "delivery" were widely used. Research focused on optimizing drug targeting, utilizing the tumor microenvironment for drug delivery, and improving delivery efficiency.
    CONCLUSION: The nanodrug delivery system, as an innovative drug delivery approach, offers numerous advantages and has garnered global attention from researchers. This study provides an analysis of the status and hotspots in nano delivery systems within the realm of breast cancer therapy, offering valuable insights for future research in this domain.
    Keywords:  Bibliometrics; Breast cancer; Nanodrug delivery system; Target; Tumor microenvironment
    DOI:  https://doi.org/10.1007/s12672-025-02014-3
  50. BioData Min. 2025 Mar 03. 18(1): 19
    Analysis of global trends and hotspots of skin microbiome in acne: a bibliometric perspective.
    Lanfang Zhang, Yuan Cai, Lin Li, Jie Hu, Changsha Jia, Xu Kuang, Yi Zhou, Zhiai Lan, Chunyan Liu, Feng Jiang, Nana Sun, Ni Zeng.
       BACKGROUND: Acne is a chronic inflammatory condition affecting the hair follicles and sebaceous glands. Recent research has revealed significant advances in the study of the acne skin microbiome. Systematic analysis of research trends and hotspots in the acne skin microbiome is lacking. This study utilized bibliometric methods to conduct in-depth research on the recognition structure of the acne skin microbiome, identifying hot trends and emerging topics.
    METHODS: We performed a topic search to retrieve articles about skin microbiome in acne from the Web of Science Core Collection. Bibliometric research was conducted using CiteSpace, VOSviewer, and R language.
    RESULTS: This study analyzed 757 articles from 1362 institutions in 68 countries, the United States leading the research efforts. Notably, Brigitte Dréno from the University of Nantes emerged as the most prolific author in this field, with 19 papers and 334 co-citations. The research output on the skin microbiome of acne continues to increase, with Experimental Dermatology being the journal with the highest number of published articles. The primary focus is investigating the skin microbiome's mechanisms in acne development and exploring treatment strategies. These findings have important implications for developing microbiome-targeted therapies, which could provide new, personalized treatment options for patients with acne. Emerging research hotspots include skincare, gut microbiome, and treatment.
    CONCLUSION: The study's findings indicate a thriving research interest in the skin microbiome and its relationship to acne, focusing on acne treatment through the regulation of the skin microbiome balance. Currently, the development of skincare products targeting the regulation of the skin microbiome represents a research hotspot, reflecting the transition from basic scientific research to clinical practice.
    Keywords:  Acne; Bibliometrics; CiteSpace; Skin microbiome; VOSviewer
    DOI:  https://doi.org/10.1186/s13040-025-00433-0
  51. Front Neurol. 2025 ;16 1474484
    A bibliometric analysis of studies on artificial intelligence in neuroscience.
    Ugur Tekin, Murat Dener.
      The incorporation of artificial intelligence (AI) into neuroscience has the potential to significantly enhance our comprehension of brain function and facilitate more effective diagnosis and treatment of neurological disorders. Artificial intelligence (AI) techniques, particularly deep learning and machine learning, offer transformative solutions by improving the analysis of complex neural data, facilitating early diagnosis, and enabling personalized treatment approaches. A bibliometric analysis is a method that employs quantitative techniques for the examination of scientific literature, with the objective of identifying trends in research, evaluating the impact of influential studies, and mapping the networks of collaboration. In light of the accelerated growth and interdisciplinary scope of AI applications in neuroscience, a bibliometric analysis is vital for mapping the landscape, identifying pivotal contributions, and underscoring emerging areas of interest. This study aims to address this need by examining 1,208 studies published between 1983 and 2024 from the Web of Science database. The analysis reveals a notable surge in publications since the mid-2010s, with substantial advancements in neurological imaging, brain-computer interfaces (BCI), and the diagnosis and treatment of neurological diseases. The analysis underscores the pioneering role of countries such as the United States, China, and the United Kingdom in this field and highlights the prevalence of international collaboration. This study offers a comprehensive overview of the current state and future directions of AI applications in neuroscience, as well as an examination of the transformative potential of AI in advancing neurological research and healthcare. It is recommended that future research address the ethical issues, data privacy concerns, and interpretability of AI models in order to fully capitalize on the benefits of AI in neuroscience.
    Keywords:  artificial intelligence; bibliometric analysis; neuroscience; research trend; scientometric analysis
    DOI:  https://doi.org/10.3389/fneur.2025.1474484
  52. BMC Med. 2025 Feb 28. 23(1): 131
    A systematic analysis of temporal trends, characteristics, and citations of retracted stem cell publications.
    Fei Song, Binghuo Wu, Gang Wei, Songtao Cheng, Lichao Wei, Wei Xiong, De Luo.
       BACKGROUND: The increasing prevalence of retracted publications in stem cell research presents significant challenges to scientific integrity. Although retraction notices are issued, retracted studies continue to be cited, facilitating the dissemination of unreliable findings. This study aimed to systematically explore the characteristics of retracted stem cell publications and evaluate the impact of retractions on subsequent citations.
    METHODS: This study was conducted following the PRISMA guidelines. A comprehensive search of Web of Science, Retraction Watch Database, and PubMed was conducted from their inception through July 25, 2024, to identify retracted stem cell publications. Characteristics including publication details, retraction reasons, and citation counts were extracted. To assess the impact of retraction on subsequent citations, we compared citation patterns between a random sample of retracted papers and matched non-retracted controls from identical journals and issues. Further analysis was conducted to determine whether papers citing retracted articles had an elevated risk of subsequent retraction. Descriptive statistics, chi-squared tests, t-tests, and Mann-Kendall tests were used for data analysis.
    RESULTS: The systematic search identified 1421 records, with 517 publications meeting inclusion criteria. Temporal analysis revealed two significant trends: an increasing retraction rate that peaked at 0.84% in 2023 and a declining time-to-retraction (median: 30 months, interquartile range: 13-60; Mann-Kendall, tau = - 0.29; P < 0.001). Hospital-affiliated researchers from China contributed to 244 (47.2%) of retractions. Data and image flaws were identified in 360 (69.6%) of retractions. Among 472 Web of Science-indexed retracted publications, 366 (77.5%) accumulated 4884 post-retraction citations, with 114 (24.2%) receiving more citations post-retraction than pre-retraction. Analysis of a random subset of retracted articles (n = 53) demonstrated that only 14 (4.2%) out of 334 post-retraction citations referenced the retraction notice. Compared with 639 non-retracted control publications, retracted articles showed significantly lower post-retraction citation rates (mean rank: 291.32 vs. 351.08; P = 0.01). Moreover, papers citing retracted articles exhibited an 11-fold higher risk of subsequent retraction (odds ratio (OR): 11.09; 95% confidence interval (CI): 7.06-17.43).
    CONCLUSIONS: This analysis reveals substantial research integrity challenges within stem cell research. These findings suggest the necessity for enhanced surveillance mechanisms and standardized protocols to identify and curtail the dissemination of flawed research.
    Keywords:  Retracted publications; Stem cell; Systematic analysis
    DOI:  https://doi.org/10.1186/s12916-025-03965-8
  53. J Multidiscip Healthc. 2025 ;18 1147-1162
    Bibliometric and Bioinformatics Analysis of Renal Impairment in Multiple Myeloma: Trends and Research Hotspots, and Associated Genetic Pathways (2000-2023).
    Huinan Jiang, Xue Bai.
       Objective: This study aims to perform a bibliometric visual analysis and bioinformatics analysis to explore the research hotspots and trends of renal impairment in multiple myeloma, including the associated genes and signal pathways over the past two decades.
    Methods: The Web of Science Core Collection database was utilized as the data source to retrieve literature on renal impairment in multiple myeloma from 2000 to 2023. The selected literature was analyzed using bibliometric and bioinformatics software, including Bibliometrix, VOSviewer 1.6.16, Citespace 5.7R5 and Cytoscape 3.7.1 software.
    Results: This study encompassed 2152 articles that were published from 2000 to 2023, demonstrating an overall upward trend in annual publications and citations. Among the set of 27 core journals examined, the "CUREUS JOURNAL OF MEDICAL SCIENCE" exhibited the highest frequency of publications, while "BLOOD" emerged as the most frequently cited source. The global research on renal impairment in multiple myeloma research included contributions from 84 countries/regions, with the United States leading in terms of publication output and Mayo Clinic playing a central role in fostering inter-agency collaboration. Keywords such as "daratumumab", "carfilzomib", "diagnostic criteria" and "kidney biopsy" included recent research hotspots. We hypothesized that the TP53, AKT1, MYC, and CTNNB1 genes were involved in epithelial cell proliferation and the positive regulation of the MAPK cascade through signaling receptor activator activity, receptor-ligand interactions, and cytokine receptor binding. Simultaneously, they were implicated in renal impairment in multiple myeloma via the PI3K/Akt and MAPK signaling pathways.
    Conclusion: This research employed bibliometric visual analysis and bioinformatics analysis to identify the current focus and future directions of studying renal impairment in multiple myeloma, as well as to explore the associated genes and signaling pathways. The management of renal impairment in patients with multiple myeloma has a significant impact on medical costs. Clinical physicians need to consider how to allocate medical resources reasonably, ensure that patients can receive necessary diagnosis and treatment, and explore cost-effective treatment options. The management of these patients requires interdisciplinary medical services, which should integrate basic and clinical research, especially the development of new treatment plans, to improve patients' quality of life and guide future treatment choices.
    Keywords:  bibliometrics; bioinformatics; multiple myeloma; renal impairment
    DOI:  https://doi.org/10.2147/JMDH.S501551
  54. Heliyon. 2025 Feb 28. 11(4): e42480
    A review on multi-objective optimization of building performance - Insights from bibliometric analysis.
    Rong Li, Zalina Shari, Mohd Zainal Abidin Ab Kadir.
      The optimization of building performance has gained significant attention over the past two decades, driven by the need for energy efficiency, occupant comfort, and environmental sustainability. This paper conducts a comprehensive bibliometric analysis of multi-objective optimization (MOO) for building performance, spanning research publications from 2003 to 2023. Utilizing advanced bibliometric tools such as CiteSpace, VoSviewer, and Bibliometrix, we analyzed 1604 documents from the Web of Science Core Collection to map collaborative networks, research trends, and citation patterns. The study identifies notable advancements in the integration of sophisticated optimization algorithms, including genetic algorithms and particle swarm optimization (PSO), with simulation platforms like EnergyPlus and MATLAB, while utilizing Artificial Neural Networks (ANN) for enhanced predictive capabilities. These integrations have markedly enhanced the efficiency and accuracy of optimizing key building performance metrics, including energy efficiency, thermal comfort, indoor air quality (IAQ), and cost-effectiveness. China and the United States emerged as leading contributors, with higher education institutions playing a critical role in research outputs. Key research hotspots identified include energy consumption, thermal comfort, life cycle assessment, and simulation-based optimization. The effectiveness of genetic algorithms in managing complex multi-objective problems has led to their widespread adoption. Looking forward, future research is anticipated to focus on the development of more integrated and intelligent optimization algorithms that leverage real-time data and user behavior, thus improving the adaptability and sustainability of building performance optimization. This study provides a detailed insight into the evolution and current trends in MOO research, laying a strong foundation for future investigations aimed at advancing building performance in the context of energy efficiency and environmental sustainability.
    Keywords:  Bibliometric analysis; Building performance; Genetic algorithms; Multi-objective optimization (MOO); Research trending topics
    DOI:  https://doi.org/10.1016/j.heliyon.2025.e42480
  55. Front Public Health. 2025 ;13 1506992
    Worldwide research trends of pregnancy hypertension in epigenetics field.
    Didi Yuan, Yangqing Huang, Hanqi Liu, Haotian Tang, Junwen Liu.
       Introduction: Hypertension in pregnancy (HIP) poses significant health risks for both mothers and infants. Development of HIP is influenced by genetic and environmental factors, with epigenetic modifications partially explaining underlying mechanisms. Bibliometric tools aid researchers in quickly gaining insights into field dynamics and trends.
    Methods: In this investigation, we conducted a search for relevant publications in the Web of Science Core Collection database using specific keywords. We employed Citespace and WOSviewer software for analysis of interconnections and co-occurrence of information across publications, countries, authors, institutions, keywords and cited literature. Ultimately, we identified 4,316 research papers on hypertension in pregnancy within the epigenetics domain (HIPE).
    Results: Our analysis revealed that China had the highest number of publications (n = 1,353, 31.35%), while the University of Melbourne was the most prolific institution (n = 107, 2.48%). Among author analysis, Tong S emerged as highly productive (n = 41, 0.95%). Preeclampsia (PE) emerged as being extensively studied among various types of HIP. High-frequency keywords associated with HIP mechanisms included oxidative stress, proliferation, apoptosis and invasion. Regarding epigenetics-related terms, DNA methylation, mRNA and ncRNA exhibited distinct heat burst periods. The number of HIPE papers demonstrated an upward trend observed through three stages of growth.
    Discussion: Our bibliometric-based study provides novel insights into current research progress on HIP from an epigenetic perspective, serving as a source of new ideas and inspiration for future investigations of HIP diseases.
    Keywords:  Citespace; VOSviewer; epigenetic; hypertension in pregnancy (HIP); preeclampsia (PE)
    DOI:  https://doi.org/10.3389/fpubh.2025.1506992
  56. Hum Vaccin Immunother. 2025 Dec;21(1): 2472496
    Emerging insights into thyroid cancer from immunotherapy perspective: A correspondence.
    Zheng Zhang, Zhao-Nan Zhang, Zhen-Xi Xu, Wen-Yu Luan, Yan-Dong Miao.
      While recent studies, such as Wang et al. have explored immunotherapy trends in thyroid cancer, methodological limitations in data retrieval persist. To address this, we implemented a refined search strategy using the Web of Science Core Collection, targeting critical fields (title, abstract, author keywords) with enhanced terminology. This approach yielded 578 publications-41% more than prior studies (e.g. 409 in Wang et al.) - demonstrating the profound impact of search precision on bibliometric outcomes. Key findings revealed a surge in publications post-2017, global collaboration patterns, and high-impact research clusters. Our study uniquely integrates bibliometric analysis with machine learning to map the evolution of thyroid cancer immunotherapy, emphasizing predictive modeling of emerging therapies and clinical translation. We further provide an open-access analytics platform to streamline data reuse, enabling researchers to identify knowledge gaps and prioritize future investigations. By enhancing methodological rigor and fostering data-driven insights, this work accelerates the translation of immunotherapy advances into clinical practice.
    Keywords:  Thyroid; bibliometrics; comment; immunotherapy; malignant tumor
    DOI:  https://doi.org/10.1080/21645515.2025.2472496
  57. Front Microbiol. 2025 ;16 1532231
    Bibliometric analysis of global research on the clinical applications of aminoglycoside antibiotics: improving efficacy and decreasing risk.
    Tengxiang Zhao, Nan Chen, Mingyue Zhang, Likai Lin, Bin Lin, Yuan Fang, Zhihui Hua, Chenyu Liang.
       Background: Infections by drug-resistant bacteria are a significant threat to human health worldwide although many drug-resistant bacteria are sensitive to aminoglycosides (AGs), an older class of antibiotics. AGs have played a significant role in clinical practice in recent years.
    Methods: Publications from 1 January 2013 to 31 December 2023 that described clinical research of AGs were identified by searching the Web of Science Core Collection Database. Visual presentations of different bibliometric networks were prepared using VOSviewer and CiteSpace.
    Results: There were 915 eligible publications and the annual number of publications increased over time. The United States had the most publications and was at the core of the cooperative network. Italy and Belgium had the highest quality publications, and many of the institutions with high yield and high research quality were in Australia. JA Roberts (University of Queensland, Australia) was the most productive author and was the author of many high-quality studies in cooperation with various other researchers. The majority of publications were in journals that focused on antibacterials, chemotherapy, and pharmacokinetics. Analysis of the most highly cited publications, references, and keywords, indicated that this research mainly focused on infections by drug-resistant bacteria, drug administration in vulnerable populations, safety, pharmacokinetics, combination therapy, and new methods of administration.
    Conclusion: AGs have an increasingly important role in the treatment of infections by multidrug-resistant bacteria. Therapeutic drug monitoring should be performed in vulnerable populations, such as the elderly, children, and infants, to improve efficacy and reduce toxicity. Avoiding prolonged dosing cycles and refraining from using AGs in patients with the m.1555 A > G gene variant can significantly mitigate the risk of ototoxicity. Future studies should examine the pharmacokinetic and pharmacodynamic targets of AGs and assess the efficacy and safety of administration by inhalation to improve efficacy and decrease risk.
    Keywords:  aminoglycoside antibiotics; antibiotic resistance; bibliometric analysis; individualized administration; therapeutic drug monitoring
    DOI:  https://doi.org/10.3389/fmicb.2025.1532231
  58. Intractable Rare Dis Res. 2025 Feb 28. 14(1): 1-13
    Rare disease publishing trends worldwide and in China: A CiteSpace-based bibliometric study.
    Qi Kong, Chenxin Fan, Ying Zhang, Xinlei Yan, Liming Chen, Qi Kang, Peihao Yin.
      This study aimed to understand research trends, determine frontier topics, and explore the developments in and the differences between research conducted in China and the rest of the world. We analyzed the research status of rare diseases in China and globally over the past decade using bibliometric methods. We focused on rare disease literature indexed in the Web of Science (WoS) and China National Knowledge Infrastructure (CNKI) databases from January 2013 to December 2023. We selected studies based on inclusion and exclusion criteria. CiteSpace 6.1.R6 software were used to prepare knowledge graphs and perform comparative analyses of authors, institutions, content, and hot topics between both databases. A total of 10,754 articles from the WoS and 969 from the CNKI met the inclusion criteria. In the past 10 years, the diagnosis and treatment of rare diseases have been a common research focus in both China and the world. China has emphasized more on "orphan drugs". "Genes" and "management" were focused globally. The United States had the greatest number of publications. China ranks high in terms of publication volume and institutional ranking. Research interest in rare diseases has gradually increased worldwide, with European and American countries maintaining a leading position. China has made significant contributions. China's research is lagging compared to global trends, lacking collaboration with other countries. The diagnosis and treatment of rare diseases remain central themes, whereas genetic research, artificial intelligence, and sociological studies on rare disease populations are emerging as hot topics.
    Keywords:  CiteSpace; knowledge graph; orphan diseases; rare diseases; visualization
    DOI:  https://doi.org/10.5582/irdr.2024.01059
  59. Cancer Imaging. 2025 Mar 04. 25(1): 24
    Imaging genomics of cancer: a bibliometric analysis and review.
    Xinyi Gou, Aobo Feng, Caizhen Feng, Jin Cheng, Nan Hong.
       BACKGROUND: Imaging genomics is a burgeoning field that seeks to connections between medical imaging and genomic features. It has been widely applied to explore heterogeneity and predict responsiveness and disease progression in cancer. This review aims to assess current applications and advancements of imaging genomics in cancer.
    METHODS: Literature on imaging genomics in cancer was retrieved and selected from PubMed, Web of Science, and Embase before July 2024. Detail information of articles, such as systems and imaging features, were extracted and analyzed. Citation information was extracted from Web of Science and Scopus. Additionally, a bibliometric analysis of the included studies was conducted using the Bibliometrix R package and VOSviewer.
    RESULTS: A total of 370 articles were included in the study. The annual growth rate of articles on imaging genomics in cancer is 24.88%. China (133) and the USA (107) were the most productive countries. The top 2 keywords plus were "survival" and "classification". The current research mainly focuses on the central nervous system (121) and the genitourinary system (110, including 44 breast cancer articles). Despite different systems utilizing different imaging modalities, more than half of the studies in each system employed radiomics features.
    CONCLUSIONS: Publication databases provide data support for imaging genomics research. The development of artificial intelligence algorithms, especially in feature extraction and model construction, has significantly advanced this field. It is conducive to enhancing the related-models' interpretability. Nonetheless, challenges such as the sample size and the standardization of feature extraction and model construction must overcome. And the research trends revealed in this study will guide the development of imaging genomics in the future and contribute to more accurate cancer diagnosis and treatment in the clinic.
    Keywords:  Bibliometric analysis; Cancer; Imaging genomics; Review
    DOI:  https://doi.org/10.1186/s40644-025-00841-9
  60. J Multidiscip Healthc. 2025 ;18 1249-1268
    Comprehensive Analysis of the Biomechanical Research of Pelvic Organ Prolapse: A Scientometric Approach.
    Haolan Du, Miyang Yang, Xuge Qi, Lanlan Yang, Zhaochu Wang, Tao Yang, Shangwen Xu, Liyuan Fu.
       Background: Pelvic organ prolapse (POP) has become a significant public health issue, with its prevalence increasing proportionally with age. Despite the considerable number of biomechanical studies reported on POP, there remains a lack of a systematic approach to summarize and synthesize all existing research.
    Methods: The Web of Science Core Collection (WoSCC) database was used as the data source to select literature published from 2003 to 2023 related to biomechanical research of POP. We employed various visualization software to generate scientific knowledge maps, facilitating data analysis and visual representation.
    Results: This study included 292 publications, comprising 252 research articles (86.3%) and 40 review articles (13.7%). The United States has emerged as a leading nation in terms of productivity, with the University of Porto making significant contributions. Robust partnerships are maintained by all countries and institutions involved. Moali PA stands out as the most prolific author, while Deprest J exhibits exemplary levels of collaboration. Notably, the journal Int Urogynecol J has the highest publication rate and citation frequency, making a significant contribution and demonstrating considerable academic influence in the field. Keyword and cluster analysis reveal that key research areas include validating finite element (FE) models of pelvic floor structures, studying interactions among pelvic support systems, evaluating the impact of vaginal delivery, assessing the effects of various mesh or 3D-printed materials on POP repair, remodeling vaginal connective tissue in POP patients, and biomechanical performance evaluations of pelvic floor tissues. Future research will likely focus on the development of personalized and regenerative treatment strategies. Moreover, advancements in machine learning, various regenerative medicine approaches, and multimodal large-scale FE modeling offer promising insights for development.
    Conclusion: This study presents a comprehensive analysis of the knowledge system and research directions of the biomechanics of POP, providing valuable guidance for future research endeavors.
    Keywords:  bibliometric; biomechanics; pelvic organ prolapse; visualization analysis
    DOI:  https://doi.org/10.2147/JMDH.S473196
  61. World J Hepatol. 2025 Feb 27. 17(2): 103016
    Liver function linked to bone health: A bibliometric of the liver-bone axis.
    Wei-Jin Zhang, Xun-Pei Xu, Xin-Hua Song, Zhan-Rong Zhang, Xuan-Rui Zhang, Biao Yang, Zheng-Bo Tao, Zheng Zhang, Xu-Hui Zhou.
       BACKGROUND: The liver exerts profound influence on skeletal health, while osseous tissues reciprocally modulate hepatic function. This bidirectional metabolic axis between these two organ systems plays a pivotal role in both physiological homeostasis and pathological states.
    AIM: To investigate and analyze the literatures on liver-bone axis using bibliometrics.
    METHODS: A comprehensive literature search pertaining to the liver-bone axis was conducted using the Science Citation Index Expanded within the Web of Science Core Collection. Subsequently, visualization and bibliometric analyses were performed utilizing VOSviewer (version 1.6.20), Citespace (version 6.2.R4), and the R programming language.
    RESULTS: This comprehensive analysis encompasses 855 publications, comprising 694 articles and 161 reviews, authored by 4988 researchers from 425 institutions across 61 countries. The United States and China emerge as the leading nations in terms of publication volume. The University of California system stands out as the most influential institution in liver-bone axis research. Guanabens N is identified as the most prolific author in this field. The annual increase in publications related to the liver-bone axis underscores its growing prominence as a research focus. The study highlights key areas of investigation, including osteoporosis, bone metabolism, non-alcoholic fatty liver disease, and insulin-like growth factor-1, which represent both current and prospective hot topics within this domain.
    CONCLUSION: This investigation employs bibliometric methodologies to conduct a systematic analysis of liver-bone axis literature spanning from 2001 to 2024. The exponential growth in publications over the past two decades underscores the significance of synthesizing research outcomes in this domain. Through rigorous statistical analyses, we delineate fundamental contributions to the field while providing strategic direction for emerging scholars. Furthermore, we illuminate current research trajectories and identify promising future investigative directions. Investigation of the liver-bone axis enhances our comprehension of inter-organ communication networks. Conceptualizing these organs as an integrated system provides profound insights into pathophysiological mechanisms and disease management strategies. This paradigm not only facilitates the development of sophisticated diagnostic modalities but also catalyzes the discovery of novel therapeutic agents targeting these mechanistic pathways, thereby advancing our capacity to diagnose and treat hepatic and skeletal disorders.
    Keywords:  Bone metabolism; Citespace; Liver; Non-alcoholic fatty liver disease; Osteoporosis; VOSviewer
    DOI:  https://doi.org/10.4254/wjh.v17.i2.103016
  62. Front Med (Lausanne). 2025 ;12 1488866
    Scientific landscape and visualization analysis of the link between adenomyosis and infertility from 2000 to 2024.
    Qiaomei Yang, Xinye Zheng, Fuchun Zhong, Li Chen, Jingxuan Hong, Xianhua Liu, Junying Jiang.
       Objectives: Adenomyosis (AM) is a chronic disorder that significantly impacts women's health and quality of life worldwide, particularly by causing progressive impairment in fertility. This study aimed to summarize and visualize the literature concerning AM-associated infertility using scientometric analysis.
    Methods: We conducted a literature search in the Web of Science™ Core Collection (WoSCC) database for "adenomyosis" and "infertility" as topics from 2000 to 2024. The collected data were organized in Microsoft Office Excel for further analysis. Bibliometric analyses and visualizations were performed using Origin, CiteSpace, VOSviewer, and the Bibliometrix package.
    Results: A total of 456 articles were published across 153 journals, reflecting a growing trend in both published and cited articles. The scholars with the highest output were Petraglia F., Chapron C., and Pellicer A., while the Fertility and Sterility were the most publications' journal. China, the United States, and Italy ranked as the top three countries globally regarding relevant publications worldwide. The 190 keywords in the literature were divided into eight clusters primarily related to pathogenesis, adverse factors affecting pregnancy, treatment methods, diagnostic methods, disease progression, in vitro fertilization (IVF) management, infertility in women, and fertility management. Current hotspots in this field include investigating potential mechanisms of pathogenesis, diagnostic strategies, and improving pregnancy outcomes for patients with AM-associated infertility.
    Conclusion: This study highlights that infertility is the most significant and complex issue associated with AM. Although chronic disease management strategies, pharmacological treatments, and assisted reproductive technologies (ART) have improved fertility outcomes in women with AM, further clinical translational research is still warranted.
    Keywords:  CiteSpace; adenomyosis; association; bibliometric analysis; infertility; research trends
    DOI:  https://doi.org/10.3389/fmed.2025.1488866
  63. J Can Health Libr Assoc. 2024 Dec;45(3): 137-146
    Librarian involvement on knowledge synthesis articles and its relationship to article citation count and Journal Impact Factor.
    Krista Louise Alexander, Katharine Hall, Yuling Max Chen.
       Introduction: Our aim was to determine if there is a relationship between librarian involvement on a knowledge synthesis project and the synthesis's citation count or the Journal Impact Factor (JIF) of its publication venue.
    Methods: A total of 551 knowledge syntheses published during a one-year period (2020) from a single category, "Psychology, Clinical", in Clarivate's Journal Citation Reports were exported from Web of Science along with the citation counts for each synthesis and the JIF of its publication venue. The full-text of each article was examined in order to code each as either co-author, acknowledged, or unknown to reflect the level of librarian involvement in the synthesis. The Wilcoxon Rank Sum test on bootstrapped samples was used to determine the significance of the results.
    Results: Librarians were co-authors or acknowledged in 80 (15%) of the syntheses examined. Analyzing two levels of librarian involvement (involved, unknown) indicated no relationship between the level of librarian involvement and the JIF of the journal nor the citation count the synthesis received since publication.
    Discussion: There is no evidence of a relationship between librarian involvement in knowledge syntheses and the JIF of the publication or citation count of documents published in journals falling in the JCR category of "Psychology, Clinical" in the year 2020. Repeating this methodology in a different JCR category could help determine whether this lack of a relationship extends beyond the "Psychology, Clinical" category.
    DOI:  https://doi.org/10.29173/jchla29798
  64. Isr J Health Policy Res. 2025 Mar 05. 14(1): 10
    Assessing the quality of studies funded by the Israel National Institute for Health Policy Research, 2010-2020.
    Dan Even, Moshe Leshno, Avi Porath.
       BACKGROUND: Research is the basis of advancement in health and wellbeing in modern societies. Our study aims to examine the funding policy of the Israel National Institute for Health Policy Research (NIHP), a national foundation responsible for assessing the impact of the national Health Insurance Law on health services in Israel. The study aims to evaluate the studies funded from 2010 to 2020, considering their publication in scientific literature and other channels that may influence decision-makers. We compare findings to a previous internal examination of studies funded by the NIHP during 1996-2014. Our paper presents an approach for measuring the impact of health policy research.
    METHODS: All 378 studies funded by NIHP during the specified years were identified. Objective data were gathered by investigating scientific literature across three datasets: Web of Science (WOS), PubMed, and Google Scholar, including journal impact factor, quarterly index, and citation metrics. Concurrently, a questionnaire was developed to collect additional and subjective data from principal investigators of the funded research projects.
    RESULTS: In the final sample of 364 studies funded by NIHP from 2010 to 2020, after 11 were cancelled, and 3 were duplicates. 436 publications were retrieved in peer-reviewed journals. The average time elapsed from funding to scientific publication was 4.65 years. Metric parameters for the top publications of 231 funded studies with at least one publication in peer-reviewed journals revealed an average journal impact factor of 5.97 points and an average of 7.82 citations according to WOS and 14 citations according to Google Scholar. A comparison to 459 funded studies from 1996 to 2014 found a twofold increase in the impact factor. Nearly half of the principal investigators reported some influence on policy processes in the questionnaires, and the majority of the studies were also reported in popular media outlets.
    CONCLUSIONS: The study provides an overview of the quality and potential influence of studies funded by NIHP, dedicated to supporting research in the field of health policy in Israel. Some of the findings are supported by results from similar inquiries. Several recommendations are introduced to enhance the quality and impact of the funded studies.
    Keywords:  Health policy research; Publication metrics; Quality assessment; Societal impact
    DOI:  https://doi.org/10.1186/s13584-025-00672-w
  65. Front Immunol. 2025 ;16 1499026
    A bibliometric and visualization analysis of the role of traditional Chinese medicine in cancer immunotherapy.
    Yixiao Lian, Jie Sun, Lin Yang, Weidong Yu.
       Objective: Traditional Chinese medicine (TCM) is used as a complementary treatment for patients with cancer, especially in immunotherapy. Although extensive clinical and basic research has been conducted on TCM in cancer immunotherapy, a comprehensive bibliometric analysis of this field has not yet been performed. This study aimed to investigate the progress and status of TCM, and the research focused on cancer immunotherapy.
    Methods: We collected 1,657 articles on TCM in cancer immunotherapy from 1994 to 2024 from the Web of Science Core Collection database. VOSviewer, CiteSpace, and the Bibliometrix R package were used to analyze countries, institutions, journals, authors, references, and keywords to predict future trends in cancer immunotherapy with TCM.
    Results: The publication rate of TCM in cancer immunotherapy research steadily increased from 1994 to 2018, with a swift growth from 2018 to 2023. China and TCM universities have achieved the most research advancements in this field. The most studied types of cancer are liver, lung, and colorectal cancers. However, few studies exist on upper respiratory tract tumors, cervical cancer, and melanoma, which deserve more attention. The study trend has gradually shifted from in vivo and in vitro models to clinical efficacy. Simultaneously, the focus of research transitioned from compound TCM preparations or classes of ingredients to specific pharmacodynamic ingredients, and the corresponding targets transitioned from cytokines to immune checkpoints. In general, molecular docking combined with multi-omics analysis is a popular and trending research method in TCM for cancer immunotherapy, helping researchers understand the mechanisms of TCM in cancer immunotherapy more comprehensively and accurately. By analyzing the literature, it is evident that TCM-based immunotherapy should contribute to effective maintenance or adjuvant therapy throughout the entire course of cancer rather than only in the late stages.
    Conclusion: This study comprehensively summarized and identified research frontiers providing a reference for promoting the development of TCM immunotherapy preparations and guiding clinical practice. Consequently, more patients with cancer can benefit from immunotherapy.
    Keywords:  Bibliometrix; CiteSpace; VOSviewer; cancer; immunotherapy; traditional Chinese medicine
    DOI:  https://doi.org/10.3389/fimmu.2025.1499026
  66. Complement Ther Med. 2025 Feb 26. pii: S0965-2299(25)00023-8. [Epub ahead of print]89 103148
    Effect of music intervention on dental anxiety and fear: A bibliometric analysis of RCTs from 2004 to 2024.
    Yena Gan, Jinwei Huang, Sheng Han, He Xu, He Zhu, Duoduo Li, Zening Wei, Feng Sun, Zhigang Cai.
       BACKGROUND: Dental treatments, especially invasive procedures, often induce anxiety and fear, impacting future treatment adherence. Music intervention, a non-pharmacological approach, has shown promise in reducing anxiety and enhancing well-being, but further research is needed to explore its application in dental settings and the influence of factors like music type, duration, and volume.
    OBJECTIVE: To assess the effects of music interventions on dental anxiety and fear, analyze research trends, and identify knowledge gaps through a bibliometric analysis of randomized controlled trials.
    METHODS: Data from eligible studies were extracted through a comprehensive search. Descriptive bibliometrics, citation analysis, and keyword analysis were performed to assess research outputs, distribution, hotspots, and trends. Different human development indices (HDI) were used to analyze variations in publication year, sex distribution, and interventions across countries.
    RESULTS: This study included 46 randomized controlled trials (RCTs) from 2004 to 2024, with a mean annual growth rate of 5.95 %. India, Japan, and Turkey led the research output and citations. Approximately 4112 participants, with 45.68 % males were enrolled. Most RCTs focused on adults (65.22 %) and used passive music interventions (73.91 %). The most common treatment was dental extraction (39.13 %), with classical music being the predominant intervention (60.87 %). The control group were often blank (80.43 %). Various indicators of anxiety and fear have been reported. Significant differences were found in the sex distribution among the different HDI ranks (p < 0.001).
    CONCLUSIONS: This study outlined the research profile of music interventions for reducing anxiety and fear during dental treatments, with India, Japan, and Turkey leading in terms of output. The most frequently studied intervention is classical music, which is typically used preoperatively. Notable sex distribution differences were observed across HDI groups. Future research trends should include more extensive trials, personalized interventions, standardized guidelines, and enhanced collaboration to optimize patient engagement and emotional regulation.
    Keywords:  Bibliometrics; Dental anxiety; Dental fear; Music interventions; Randomized controlled trials
    DOI:  https://doi.org/10.1016/j.ctim.2025.103148
  67. J Perioper Pract. 2025 Mar 04. 17504589251320811
    A bibliometric analysis of perioperative medicine and artificial intelligence.
    Luke Kar Man Chan, Brooke Perrin Mao, Rebecca Zhu.
       BACKGROUND: Artificial intelligence holds the potential to transform perioperative medicine by leveraging complex datasets to predict risks and optimise patient management in response to rising surgical volumes and patient complexity.
    AIM: This bibliometric analysis aims to analyse trends, contributions, collaborations and research hotspots in artificial intelligence and perioperative medicine.
    METHODS: A Scopus search on 11 October 2024 identified articles on artificial intelligence in perioperative medicine. Relevant peer-reviewed studies were screened by two reviewers, with a third resolving discrepancies. Data were analysed using VOSviewer, Biblioshiny and Microsoft Excel.
    RESULTS: A total of 240 articles were included; 84% of articles were published after 2018, indicating rapid recent growth. The United States, China and Italy led contributions. Single-country publications comprised 76.6% of the dataset, reflecting limited international collaboration. Key research areas included perioperative risk prediction, intraoperative monitoring, blood management and echocardiography.
    CONCLUSION: Artificial intelligence in perioperative medicine is rapidly advancing but requires increased international collaboration to fully realise its potential.
    Keywords:  Anaesthesia; Artificial intelligence; Bibliometric; Intraoperative monitoring; Machine learning; Monitoring; Perioperative; Perioperative care; Perioperative medicine; Risk assessment; Risk prediction; Technology in medicine
    DOI:  https://doi.org/10.1177/17504589251320811
  68. J Liq Biopsy. 2024 Dec;6 100165
    Global landscape of liquid biopsy research: Regional contributions and disparities.
    Siddig Ibrahim Abdelwahab, Abdullah Farasani, Hassan Ahmad Alfaifi, Waseem Hassan.
       Objective: Liquid biopsy has revolutionized cancer research, diagnosis, and personalized treatment. This study aimed to explore regional contributions and disparities in this rapidly advancing field.
    Method: The Scopus database was utilized for data retrieval in June 2024. A total of 2761 documents, including 1605 articles and 1156 reviews, were analyzed. These documents received 70,837 citations with h-index of 105.
    Results: Europe was the most prolific region, contributing 1645 documents with 53,728 citations and an h-index of 94. Asia followed with 607 documents, receiving 17,116 citations and an h-index of 62. The Middle East, South America, and Africa had significantly fewer publications, with 44, 41, and 5 documents respectively. The Middle East's publications earned 840 citations and an h-index of 15, South America's documents garnered 725 citations and an h-index of 16, and Africa's modest contribution accumulated 61 citations and an h-index of 3.
    Conclusion: Despite the remarkable growth and applications of liquid biopsy, significant regional disparities in research contributions and impacts are evident. Addressing these disparities is crucial for ensuring more equitable advancements and access to liquid biopsy technologies worldwide.
    Keywords:  Bibliometrics; Liquid biopsy; Regions; Scopus
    DOI:  https://doi.org/10.1016/j.jlb.2024.100165
  69. Investig Clin Urol. 2025 Mar;66(2): 172-180
    Changes in urologic research from a new perspective: Text mining analysis of publication topics.
    Soohyung Joo, Kun Lu, Jihwan Park, Mi Jung Rho, Yong Hyun Park.
       PURPOSE: This study aimed to explore the trends in research keywords and topics in the field of urology based on text mining over the recent decades. The investigation looked into changes in frequent subject keywords and the trends in prevailing research topics, as reflected in representative urology journals over recent decades.
    MATERIALS AND METHODS: A total of 27,129 bibliographic documents were collected from four urology journals, including European Urology, Journal of Urology, BJU International, and World Journal of Urology. The study then examined the changes in the most frequent author keywords over the decades. Moreover, structured topic modeling was employed to identify twenty prevailing research topics in urology and to examine their trends across different periods.
    RESULTS: The study observed consistently increasing patterns in author keywords and topics related to the prostate and oncology. Conversely, research fields such as pediatrics, male infertility, voiding dysfunction, and cancer biology exhibited a downward trend in urology. Potential factors or reasons underlying these trends were further discussed in this study.
    CONCLUSIONS: This exploratory study uncovered major research topics in the discipline of urology. The findings of this study depict the domain of urology research in recent decades, providing insights for both researchers and clinicians seeking to better understand the research trends in the discipline.
    Keywords:  Research; Text mining; Topic modelling; Trend analysis; Urology
    DOI:  https://doi.org/10.4111/icu.20240388
  70. Turk J Phys Med Rehabil. 2024 Dec;70(4): 427-432
    The fate of manuscripts rejected by the Turkish Journal of Physical Medicine and Rehabilitation.
    Duygu Geler Külcü, Birkan Sonel Tur, Burcu Yanık, Şebnem Koldaş Doğan, Ayşe Nur Bardak, Coşkun Zateri, Deniz Evcik.
       Objectives: The aim of this study was to evaluate the fate of the articles after they were rejected from the Turkish Journal of Physical Medicine and Rehabilitation (Turk J Phys Med Rehab).
    Materials and methods: Between January 2016 and December 2021, rejected manuscripts by the Turk J Phys Med Rehab were retrospectively analyzed and whether these rejected articles were published in another journal was identified. For the manuscripts published elsewhere, article type, change in the article name, and the number and order of authors were noted. The index of the new journal, the impact factor for SCI-E journals and journal quartile were recorded. Whether the journal was a national journal/international journal, a specialty or non-specialty journal, and whether the impact factors were higher, lower, or the same as Turk J Phys Med Rehab were evaluated.
    Results: Totally, 76% of 1,051 rejected articles were accepted for publication in another journal, after an average of 13.73 months. The name of the article, the order of the authors, and the number of the authors remained unchanged in 71.4%, 79.3%, and 80.8% of the articles, respectively. A total of 69.9% of the journals were non-specialty journals and 61.8% were general international medical journals. In addition, 32.6% of the journals were included in the SCI-E, and 70.9% of the articles in SCI-E were included in the Q4 and Q3 scope. The impact factor with 51.9% were lower or the same with the Turk J Phys Med Rehab.
    Conclusion: Our study results showed that a high percentage of the articles rejected by the Turk J Phys Med Rehab found a place in another journal later, and that non-specialty journals that accept general articles were more prominent in the selection of journal. The fact that an article rejected from a journal can be corrected and amended in accordance with valuable reviewer comments by improving its academic quality and seeking success in other journals may be promising for researchers who submit their articles to journals.
    Keywords:  <em>Turk J Phys Med Rehab; Fate; Turkish Journal of Physical Medicine and Rehabilitation.</em>; manuscript; rehabilitation; rejection
    DOI:  https://doi.org/10.5606/tftrd.2024.15462
  71. Intractable Rare Dis Res. 2025 Feb 28. 14(1): 14-28
    A bibliometric study of rare diseases in English and Chinese databases from 1985 to 2024 based on CiteSpace.
    Mengru Tian, Shuyi Wang, Zhihui Meng, Xin Zhang, Jinxiang Han, Yanqin Lu.
      This study utilizes CiteSpace (version 6.2.R3) to visually analyze literature related to rare diseases, summarizing the current research status and hotspots in the field. The goal was to provide broader perspectives and references for researchers in rare diseases. A comprehensive search for relevant literature in the rare diseases domain was conducted through the China Knowledge Network (CNKI) and Web of Science (WOS), spanning the years 1985 to 2024. Then, CiteSpace software was utilized to create a visual map of the annual publication volume, authors, institutions, keywords, and other content. After screening, 2,293 Chinese and 2,262 English articles were included in the study. Over the last several decades, the diagnosis and treatment of rare diseases have been a common research focus in both China and foreign countries, but there is a significant research depth and breadth gap. In China, there is a shortage of core authors and high-quality literature, and the level of collaboration among research teams is significantly lower compared to the robust international cooperation between authors and institutions. High-frequency and central keywords in the field include "orphan drugs", "children", and "genetic mutations", reflecting research hotspots in this domain. Research on rare diseases has been increasing annually, with key directions focusing on orphan drug development, novel therapeutic agents, genetic therapies, and healthcare security. In the research field of rare diseases, emphasis should be placed on early detection, early prevention, and early treatment. The application of genetic diagnostic techniques in clinical practice will have a broader prospect. This will be one of the direction for future research in this area.
    Keywords:  CiteSpace; knowledge map; rare disease; visual analysis
    DOI:  https://doi.org/10.5582/irdr.2024.01062
  72. J Med Internet Res. 2025 Mar 04. 27 e56692
    Use of Artificial Intelligence, Internet of Things, and Edge Intelligence in Long-Term Care for Older People: Comprehensive Analysis Through Bibliometric, Google Trends, and Content Analysis.
    Shuo-Chen Chien, Chia-Ming Yen, Yu-Hung Chang, Ying-Erh Chen, Chia-Chun Liu, Yu-Ping Hsiao, Ping-Yen Yang, Hong-Ming Lin, Tsung-En Yang, Xing-Hua Lu, I-Chien Wu, Chih-Cheng Hsu, Hung-Yi Chiou, Ren-Hua Chung.
       BACKGROUND: The global aging population poses critical challenges for long-term care (LTC), including workforce shortages, escalating health care costs, and increasing demand for high-quality care. Integrating artificial intelligence (AI), the Internet of Things (IoT), and edge intelligence (EI) offers transformative potential to enhance care quality, improve safety, and streamline operations. However, existing research lacks a comprehensive analysis that synthesizes academic trends, public interest, and deeper insights regarding these technologies.
    OBJECTIVE: This study aims to provide a holistic overview of AI, IoT, and EI applications in LTC for older adults through a comprehensive bibliometric analysis, public interest insights from Google Trends, and content analysis of the top-cited research papers.
    METHODS: Bibliometric analysis was conducted using data from Web of Science, PubMed, and Scopus to identify key themes and trends in the field, while Google Trends was used to assess public interest. A content analysis of the top 1% of most-cited papers provided deeper insights into practical applications.
    RESULTS: A total of 6378 papers published between 2014 and 2023 were analyzed. The bibliometric analysis revealed that the United States, China, and Canada are leading contributors, with strong thematic overlaps in areas such as dementia care, machine learning, and wearable health monitoring technologies. High correlations were found between academic and public interest, in key topics such as "long-term care" (τ=0.89, P<.001) and "caregiver" (τ=0.72, P=.004). The content analysis demonstrated that social robots, particularly PARO, significantly improved mood and reduced agitation in patients with dementia. However, limitations, including small sample sizes, short study durations, and a narrow focus on dementia care, were noted.
    CONCLUSIONS: AI, IoT, and EI collectively form a powerful ecosystem in LTC settings, addressing different aspects of care for older adults. Our study suggests that increased international collaboration and the integration of emerging themes such as "rehabilitation," "stroke," and "mHealth" are necessary to meet the evolving care needs of this population. Additionally, incorporating high-interest keywords such as "machine learning," "smart home," and "caregiver" can enhance discoverability and relevance for both academic and public audiences. Future research should focus on expanding sample sizes, conducting long-term multicenter trials, and exploring broader health conditions beyond dementia, such as frailty and depression.
    Keywords:  Google Trends; Internet of Things; artificial intelligence; bibliometric analysis; content analysis; edge intelligence; long-term care; older adults
    DOI:  https://doi.org/10.2196/56692
  73. Cancer Prev Res (Phila). 2025 Mar 03. 18(3): 109
    Editors' Selections from Relevant Scientific Publications.
      
    DOI:  https://doi.org/10.1158/1940-6207.CAPR-18-3-HFL
  74. Digit Health. 2025 Jan-Dec;11:11 20552076251324444
    Application of large language models in healthcare: A bibliometric analysis.
    Lanping Zhang, Qing Zhao, Dandan Zhang, Meijuan Song, Yu Zhang, Xiufen Wang.
       Objective: The objective is to provide an overview of the application of large language models (LLMs) in healthcare by employing a bibliometric analysis methodology.
    Method: We performed a comprehensive search for peer-reviewed English-language articles using PubMed and Web of Science. The selected articles were subsequently clustered and analyzed textually, with a focus on lexical co-occurrences, country-level and inter-author collaborations, and other relevant factors. This textual analysis produced high-level concept maps that illustrate specific terms and their interconnections.
    Findings: Our final sample comprised 371 English-language journal articles. The study revealed a sharp rise in the number of publications related to the application of LLMs in healthcare. However, the development is geographically imbalanced, with a higher concentration of articles originating from developed countries like the United States, Italy, and Germany, which also exhibit strong inter-country collaboration. LLMs are applied across various specialties, with researchers investigating their use in medical education, diagnosis, treatment, administrative reporting, and enhancing doctor-patient communication. Nonetheless, significant concerns persist regarding the risks and ethical implications of LLMs, including the potential for gender and racial bias, as well as the lack of transparency in the training datasets, which can lead to inaccurate or misleading responses.
    Conclusion: While the application of LLMs in healthcare is promising, the widespread adoption of LLMs in practice requires further improvements in their standardization and accuracy. It is critical to establish clear accountability guidelines, develop a robust regulatory framework, and ensure that training datasets are based on evidence-based sources to minimize risk and ensure ethical and reliable use.
    Keywords:  ChatGPT; Large language models; bibliometric analysis; health care; literature analysis
    DOI:  https://doi.org/10.1177/20552076251324444
  75. Oral Maxillofac Surg. 2025 Mar 04. 29(1): 60
    Comparing academic productivity and Instagram presence in oral and maxillofacial surgery training programs.
    Jamie Rose, Boyu Ma, Edwin M Rojas, Jaime Castro-Núñez.
       BACKGROUND: Social media has become an increasingly important tool in how surgeons collaborate with one another, disseminate educational information, and communicate with patients.
    PURPOSE: The purpose of this study was to assess the relationship between academic productivity and social media (Instagram) presence amongst oral and maxillofacial surgery programs.
    STUDY DESIGN, SETTING, SAMPLE: A cross-sectional study was used to identify oral and maxillofacial surgery programs and their respective residency Instagram accounts. Information regarding number of followers, posts, and likes were recorded for each program. Academic productivity metrics for each faculty including H-index, number of publications, and number of citations were recorded.
    PREDICTOR/EXPOSURE/INDEPENDENT VARIABLE: The independent variable was the type of residency program: certificate, dual-degree, or combined track.
    MAIN OUTCOME VARIABLE(S): The main outcome variable was the academic influence quantified by h-index, citations, and publications of the programs and their social media influence quantified by number of followers/posts.
    COVARIATES: Instagram posts were categorized into departmental posts, educational, social, professional and miscellaneous. Engagement was further quantified by the number of likes.
    ANALYSES: Descriptive statistics, one-way ANOVA, Tukey's Multiple Comparisons tests, ROUT's outlier test (Q = 0.1%), and linear regression plots with a P value < 0.05.
    RESULTS: Instagram accounts were identified for 65 (73%) of the 89 programs. There was a statistically significant moderately positive correlation between the number of followers for a program's Instagram account compared with the number of publications (r = 0.5110, P  < 0.001). There was a statistically significant weakly positive correlation between the number of followers for a program's Instagram account compared with average faculty h-index(r = 0.4982, P  < 0.001), and number of citations (r = 0.4300, P  < 0.001). There was a statistically significant weakly positive correlation between the number of posts for a program's Instagram account compared with average faculty h-index (r = 0.3438, P < 0.001), number of publications (r = 0.3580, P = 0.001), and number of citations (r = 0.3973, P  < 0.001). Across all programs combined, educational posts garnered more likes compared to miscellaneous (P = 0.0129), social (P = 0.0018), departmental (P = 0.0005), and professional posts (P < 0.0001).
    CONCLUSION/RELEVANCE: There was a moderately positive correlation between average faculty H-index and number of followers for an oral and maxillofacial surgery program's Instagram account. There was a weak positive correlation between other measures of academic productivity and social media presence. Educational content garnered the most engagement from followers, despite surgery accounts mostly generating departmental focused posts.
    Keywords:  Education; Oral and maxillofacial surgery; Social media
    DOI:  https://doi.org/10.1007/s10006-025-01354-2
  76. Explor Res Clin Soc Pharm. 2025 Mar;17 100576
    Towards eco-friendly pharmaceuticals: Regulatory and policy approaches for sustainable medicines use.
    Ammar Abdulrahman Jairoun, Sabaa Saleh Al-Hemyari, Moyad Shahwan, Sahab Alkhoujah, Faris El-Dahiyat, Ammar Ali Saleh Jaber, Sa'ed H Zyoud.
       Objectives: The current study aimed to investigate how regulatory frameworks and policies are used to support the use of sustainable medicines within the pharmaceutical sector.
    Methods: The Scopus database was searched to retrieve papers. Advanced search tool of the Scopus online database was used focused on the papers that have the search query included in their titles. Data analysis incorporated bibliometric indicators like publication counts and trends, visualized through VOSviewer software version 1.6.20.
    Key findings: A total of 43 publications on Sustainable Medicines Use were found between 2000 and 2024. Leading countries in publication output on sustainable medicines use were United Kingdom, United States, India, Italy, Portugal, and Switzerland, indicating their collaborative relationships and publication volumes. A total of 92 institutions have been involved in research on Sustainable Medicines Use. Key institutions such as the Faculty of Engineering and the Laboratory for Process and Environmental Engineering, Lowell Center for Sustainable Production, Greiner Environmental Inc., and the University of Florence are prominently featured, indicating their significant contributions to research in this area. Key journals such as the "Journal of Cleaner Production," "Business Strategy and the Environment," "Chemical Engineering Transactions," "Benchmarking," and "Lecture Notes in Mechanical Engineering" are prominently featured. The retrieved articles have been cited an average count of 22.26. The overlay visualization created using VOSviewer suggest a shift towards exploring new drug categories, innovative approaches, and the commercial aspects of sustainability. Future research directions are likely to delve deeper into innovative methods and sustainable chemical practices (green chemistry), reflecting an emphasis on developing greener processes and products.
    Conclusion: This study offers a thorough analysis of the legislative and governmental strategies promoting the use of sustainable medicine. It offers important insights for promoting sustainability in the pharmaceutical industry by pointing out gaps, defining useful frameworks, and suggesting doable solutions. Achieving sustainable pharmaceutical practices that support worldwide environmental and public health objectives requires sustained research, policy development, and international cooperation. The area needs to keep developing and implementing sustainable methods like green chemistry to decrease environmental harm and improve sustainability. Furthermore, collaborations among academia, industry, and international organizations are essential to progress and interchange effective strategies.
    Keywords:  Environmental impact; Sustainability; Sustainable medicines; Sustainable pharmaceuticals
    DOI:  https://doi.org/10.1016/j.rcsop.2025.100576
  77. Acta Psychol (Amst). 2025 Feb 27. pii: S0001-6918(25)00111-8. [Epub ahead of print]254 104798
    The research focus of academicians in analyzing women entrepreneurship intentions: A 40-year scientometric review with thematic analysis and NGT.
    Bhairab Chandra Patra, Neha Kumari.
      This paper aims to present a robust view of the research focus of academic scholars on women entrepreneurship intentions over the last four decades by applying a scientometric approach that integrates thematic analysis and the Nominal Group Technique (NGT). The scientometric analysis of articles was conducted at three levels, i.e., micro, meso, and macro levels through article level, author level, and journal level analysis, respectively. Crucial themes in the field of entrepreneurial intentions of women were found through co-occurrence analysis. The consistency of themes was evaluated across the three levels. Themes consistent across all levels, i.e., Country/Place Centric, Gender Specific, Education Related, Tool Centric, Theory Centric, Motivation Centric, Self-efficacy, Entrepreneurialism, and Personal Factors, were considered to be more impactful because of their importance at all levels. The process of NGT was then carried out to identify the most impactful factors from the identified themes. The most impactful factors identified in the study were attitude, self-efficacy, motivation, role models, culture, politics, and entrepreneurial education. The findings of the study will help in shaping future policies by the government in order to meet the needs of potential women entrepreneurs. To the best of the authors' knowledge, no such study across the levels of research has been conducted in the domain of women entrepreneurship.
    Keywords:  Entrepreneurial intention; Nominal Group Technique; Women entrepreneurs
    DOI:  https://doi.org/10.1016/j.actpsy.2025.104798
  78. PLoS One. 2025 ;20(3): e0317736
    Citation penalties following sexual versus scientific misconduct allegations.
    Giulia Maimone, Gil Appel, Craig R M McKenzie, Ayelet Gneezy.
       BACKGROUND AND AIM: Citations in academia have long been regarded as a fundamental means of acknowledging the contribution of past work and promoting scientific advancement. The aim of this paper was to investigate the impact that misconduct allegations made against scholars have on the citations of their work, comparing allegations of sexual misconduct (unrelated to the research merit) and allegations of scientific misconduct (directly related to the research merit).
    METHODS: We collected citation data from the Web of Science (WoS) in 2021, encompassing 31,941 publications from 172 accused and control scholars across 18 disciplines. We also conducted two studies: one on non-academics (N = 231) and one on academics (N = 240).
    RESULTS: The WoS data shows that scholars accused of sexual misconduct incur a significant citation decrease in the three years after the accusations become public, while we do not detect a significant citation decrease for scholars accused of scientific misconduct. The study involving non-academics suggests that individuals are more averse to sexual than to scientific misconduct. Finally, contrary to the WoS data findings, a sample of academics indicates they are more likely to cite scholars accused of sexual misconduct than those accused of scientific misconduct.
    CONCLUSIONS: In the first three years after accusations became public, scholars accused of sexual misconduct incur a larger citation penalty than scholars accused of scientific misconduct. However, when asked to predict their citing behavior, scholars indicated the reverse pattern, suggesting they might mis-predict their behavior or be reluctant to disclose their preferences.
    DOI:  https://doi.org/10.1371/journal.pone.0317736
  79. Aquac Nutr. 2025 ;2025 5746972
    Multifaceted Role of Probiotics in Enhancing Health and Growth of Aquatic Animals: Mechanisms, Benefits, and Applications in Sustainable Aquaculture-A Review and Bibliometric Analysis.
    Madhulika, Soibam Ngasotter, Maibam Malemngamba Meitei, Tao Kara, Martina Meinam, Sanjeev Sharma, Sanjaykumar Karsanbhai Rathod, Sanjenbam Bidyasagar Singh, Soibam Khogen Singh, Raja Aadil Hussain Bhat.
      Probiotics play a pivotal role in enhancing the health and growth of aquatic animals in aquaculture. These beneficial microorganisms contribute to improved digestion and nutrient absorption by producing digestive enzymes such as amylases, proteases, and lipases, besides providing essential nutrients. By creating a favorable microbial balance in the gastrointestinal tract (GIT), probiotics reduce harmful microorganisms and promote the proliferation of beneficial bacteria like Lactobacillus spp. and Bifidobacterium spp. This modification of gut microflora leads to more efficient digestion and significantly enhances overall health and growth performance in fish. Additionally, probiotics produce antimicrobial substances, such as bacteriocins and organic acids, which inhibit pathogenic bacteria and bolster disease resistance. They also play a crucial role in improving water quality in aquaculture systems by aiding in the turnover of organic nutrients and reducing toxic substances. Incorporating probiotics into aquaculture practices has demonstrated considerable potential in boosting the productivity and health of aquatic animals, making them an essential component of sustainable aquaculture. This review delves into the multifaceted benefits of probiotics, including enhanced feed utilization, immune responses, and pathogen resistance, and elucidates the mechanisms underlying these effects. Furthermore, it includes a bibliometric analysis of the past 30 years, providing a comprehensive overview of research trends and advancements in this field.
    Keywords:  aquaculture; bibliometrics; gut health; nutrition; probiotics
    DOI:  https://doi.org/10.1155/anu/5746972
  80. Medicine (Baltimore). 2025 Feb 28. 104(9): e41664
    Global systematic mapping of Vibrio species pathogenicity: A PRISMA-guided cluster-based analysis.
    Hope Onohuean, Uchechukwu U Nwodo.
       BACKGROUND: A systematic global map on toxigenesis and genomic virulence of Vibrio spp. was analyzed for research progress to identify the emerging research patterns for establishing a database for designing future interventions.
    METHOD: The databases (Web of Science and Scopus) were analyzed with Voxviewer software to map the global scale of Vibrio spp. or virulence toxin/genes publications and standardized using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) strategies.
    RESULTS: The results identified 1162 (Web of Science n = 620, Scopus n = 542), while 314 studies qualified for inclusion and were significantly analyzed on virulence toxin/genes. By co-citation analysis, 4-thematic clusters were developed from 6420 citations and a total reference of 9062. Cluster #1 (pathogenesis & virulence factors) and cluster #4 (host response factors) generated the utmost publications and citations (n = 40, 643) and the least (n = 7, 85) interest by the researcher. Whereas 8-thematic clusters were developed by bibliographic coupling technique analysis, cluster#1 and cluster#8 generated the utmost (n = 78, 1684) and least (n = 7, 81) publications and citations interest by the researcher.
    CONCLUSIONS: Our findings suggest that Vibrio toxigenesis and virulence factors are a complex field requiring an interdisciplinary approach consisting of interconnected perspectives that have important consequences for academics and policymakers.
    DOI:  https://doi.org/10.1097/MD.0000000000041664
  81. Int J Biol Macromol. 2025 Feb 26. pii: S0141-8130(25)02116-6. [Epub ahead of print]306(Pt 2): 141565
    Using network analysis and large-language models to obtain a landscape of the literature on dressing materials for wound healing: The predominance of chitosan and other biomacromolecules: A review.
    Jaromir Klarak, Ana Caroline M Brito, Luan F Moreira, Filipi N Silva, Diego R Amancio, Robert Andok, Maria Cristina F Oliveira, Maria Bardosova, Osvaldo N Oliveira.
      We present an overview of the literature on dressing materials for wound healing, combining network analysis and natural language processing using large language models. Contributions to this field come from a variety of research areas and journals, so we employed multiple strategies for searching the OpenAlex database to ensure that the most relevant papers were covered, while also focusing on the specific topic of interest. Citation networks were created from the retrieved papers, identifying clusters that represent major topics. Starting with broad searches on 'wound' and 'wound healing' we refined the focus to dressing materials by incorporating expert knowledge into the analysis. This approach also allowed for a comparison with fully automated analyses. The resulting landscape shows significant growth in this area in recent years, with most contributions coming from the Northern Hemisphere, particularly China and the USA. The most commonly used materials include gauze, hydrocolloids, chitosan-based hydrogels, foams, alginates, hydrofibers (e.g., those containing nanomaterials such as silver nanoparticles), composites, biomaterials, and skin substitutes. Research primarily focuses on the antibacterial properties of these materials and their application in treating burn-related wounds, which, along with diabetes, are common causes of chronic wounds.
    Keywords:  Dressings; Large-language models; Natural language processing; Network analysis; Wound healing
    DOI:  https://doi.org/10.1016/j.ijbiomac.2025.141565
  82. Neurosurg Focus. 2025 03 01. 58(3): E9
    Significance, applications, and contributions of Gamma Knife radiosurgery in advancing neurosurgical care in lower-middle-income countries: a systematic review.
    Sudharman Sitaraman, Bhavya Pahwa, L Dade Lunsford, Varun Rao.
       OBJECTIVE: Gamma Knife radiosurgery (GKRS) is an important neurosurgical intervention most commonly used for pathologies such as meningiomas, acoustic neuromas, paragangliomas, arteriovenous malformations, and trigeminal neuralgia. While the widespread availability of GKRS in developed countries makes it ubiquitous in neurosurgical research, there is a huge disparity in research in lower-middle-income countries (LMICs). This study aimed to quantify research undertaken by authors in LMICs on GKRS.
    METHODS: The authors systematically reviewed PubMed for research articles that reported on GKRS from LMICs. Studies reporting on neurosurgically treated pathologies in which either the first or corresponding author was affiliated with an institution in an LMIC were included.
    RESULTS: A total of 190 papers from LMICs met the criteria; 142 articles were from Asia and 48 were from Africa. India had the highest number of papers, whereas no papers from LMICs in South America or Oceania met the criteria for inclusion. The most frequently published type of study was retrospective, tumors were the most common pathologies studied, and arteriovenous malformations were the single most studied individual pathology. There was no significant difference in the mean number of each article type or for neoplastic, vascular, or functional pathologies per country between Asia and Africa. Articles were most often published in Neurology India, and 24 studies had a female first author, whereas 22 had a female corresponding author.
    CONCLUSIONS: This study reveals the relatively low number of studies providing high-quality evidence from LMICs such as randomized controlled trials and meta-analyses, as well as gender inequities and very high disparities among LMICs in GKRS research.
    Keywords:  Gamma Knife radiosurgery; global neurosurgery; health equity; lower-middle-income countries; women in neurosurgery
    DOI:  https://doi.org/10.3171/2024.12.FOCUS24760
  83. Curr Med Res Opin. 2025 Mar 08. 1-6
    Web references are not eternal: time-trend and qualitative impact of the loss of access to online resources cited in peer-reviewed medical journals.
    Benjamin Lemaire, Fanélie Bauer, Elena Chaves Rodriguez, Jonathan Ghesquiere, Amandine Radziejwoski, Aurélie Roth, Maud Boyer.
       OBJECTIVE: Web resources can contain high-quality data relevant to peer-reviewed medical publications. However, their online location may change or disappear with time. As medical publication professionals, we are concerned with the ephemeral nature of web resources and the associated qualitative impact on publication integrity of referencing such resources.
    METHODS: Time-dependence of the phenomenon was probed using a dataset of reference lists from open and free access articles published in 2018. Each reference list was manually screened to tally the number of web pages no longer accessible. The analysis was repeated yearly from 2021 to 2023. Additionally, a set of proofs was analyzed to investigate the proportion of cited web references already inaccessible at publication. A third dataset, consisting of modeling articles published in 2018-2023, was used to quantify -at a single timepoint- the share of web resources cited as model inputs that were inaccessible.
    RESULTS: The proportion of inaccessible web resources increased on average from 27.2% to 41.9% three to five years post publication (n = 992 articles), respectively. One out of four analyzed proofs cited at least one inaccessible web resource (n = 50). Five years after publication, 26.1% of web resources used as model inputs were no longer accessible, with one in three modeling articles being impacted (n = 61).
    CONCLUSION: The issue of inaccessible web resources cited in peer-reviewed medical publications is of great concern due to the fast pace and potential impact on research reproducibility. These findings call for the definition of best practices involving all stakeholders and the deployment of robust archiving solutions.
    Keywords:  Best practices; digital preservation; medical communication; reference rot; web references
    DOI:  https://doi.org/10.1080/03007995.2025.2475091
  84. J Am Acad Orthop Surg. 2025 Mar 04.
    Increasing Research Productivity and Step 2 Score Among Matched Orthopaedic Surgery Residents: A Forecasting Analysis to 2040.
    Benjamin M Varieur, Ryan C White, Christopher M Bono.
       BACKGROUND: Orthopaedics has consistently been among the most competitive residency specialties in which to match. The purpose of this study was to evaluate trends in important data as provided by the National Resident Matching Program regarding orthopaedic surgery residency and to project future averages for successful applicants.
    METHODS: "Charting Outcomes in the Match" are biennial reports published by the National Resident Matching Program, listing applicant characteristics stratified by specialty. We collected data between 2014 and 2024 for allopathic medical school seniors from the United States that successfully matched into orthopaedic surgery residency. Regression analysis was performed to predict research productivity and United States Medical Licensing Examination Step 2 scores to the year 2040.
    RESULTS: Research productivity and Step 2 score have shown notable trends among matched orthopaedic surgery residency applicants, with research productivity following an exponential increase (R2 = 0.988, P < 0.001) and Step 2 scores following a linear trend (R2 = 0.925, P = 0.002). In accordance with these models, by the year 2040, matched applicants are projected to have an average of 165.6 (95% prediction interval, 107.8 to 254.5) publications, posters, abstracts, and presentations and an average Step 2 score of 266 (95% prediction interval, 261 to 271) points, outperforming the 87th percentile. Specifically, Step 2 score is projected to increase by 1.1 point every 2 years with the limitation that the upper limit score is 300.
    CONCLUSION: Research productivity and USMLE Step 2 scores among matched orthopaedic surgery residency applicants are projected to increase in the coming years. These findings can inform medical school administration, residency programs, and orthopaedic leadership to optimize their programs for student, resident, and organizational success. Moreover, it may be time to reconsider the importance of these metrics as a perpetual increase in scores and research activity is not sustainable nor equitable.
    DOI:  https://doi.org/10.5435/JAAOS-D-24-01106
  85. Med Ref Serv Q. 2025 Mar 03. 1-12
    Effect of Citation Numbers and Team Members on the Possibility of and Time Needed to Complete Screening for Systematic and Scoping Reviews.
    E Barrett-Catton, E P Jones, R B Carlson.
      Covidence is a tool that facilitates systematic review screening. Librarians obtained Covidence review data from a large research institution to identify the effect that the total number of citations, team members, and librarian collaboration has on the possibility of completion and time needed for screening. The fewer the citations and the fewer the citations per collaborator, the more likely the team is to complete title and abstract and full text screening, and the faster they will finish the screening process. This relationship was stronger for the number of citations per collaborator than the number of citations alone.
    Keywords:  Covidence; screening; systematic reviews; time
    DOI:  https://doi.org/10.1080/02763869.2025.2471879
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