bims-evares Biomed News
on Evaluation of research
Issue of 2025–02–09
sixty-four papers selected by
Thomas Krichel, Open Library Society
  1. The top 50 cited publications relating to femoral shaft fractures - A bibliometric analysis of the literature.
  2. Anxiety disorders and the gut microbiota: a bibliometric and visual analysis.
  3. Influential publications in sudden hearing loss: a bibliometric and visual synopsis of the top 100 cited articles.
  4. Exploring the Landscape of Salivary Gland Disorders: A Comprehensive Bibliometric Analysis.
  5. Research trends and network approach of critical thinking skills in English Language Teaching - A bibliometric analysis implementing R studio.
  6. Bibliometric analysis of pyroptosis in pathogenesis and treatment of acute lung injury.
  7. Trends of publications on primary sarcomas of bone: A bibliometric analysis.
  8. Recent trends in research on the role of cholesterol in leukemia: a bibliometric and visualization study.
  9. Global trends in proximal femoral trabecular research: A bibliometric and visualized analysis.
  10. Evolution in optical molecular imaging techniques guided nerve imaging from 2009 to 2023: a bibliometric and visualization analysis.
  11. Global trends in migraine and anxiety over the past 10 years: a bibliometric analysis.
  12. Mapping 60 Years of Psychophysiology: A Bibliometric Analysis of Journal Performance, Authorship Trends, and Thematic Evolution.
  13. Research hotspots and trends of acupoint and pain based on PubMed: a bibliometric analysis.
  14. Trends in camel research in South Asia: A bibliometric approach.
  15. Research Hotspots and Trends in Acupuncture for Cancer:A bibliometric analysis from 2004 to 2024.
  16. Advancements in Telemedicine for Surgical Practices: A Comprehensive Bibliometric Analysis.
  17. Global trends and emerging insights in BRAF and MEK inhibitor resistance in melanoma: a bibliometric analysis.
  18. Profile of Chlamydia vaccine research: A bibliometric analysis.
  19. From Night to Light: A Bibliometric Analysis of the Global Research Trajectory of Sleep Disorders in Parkinson's Disease.
  20. Global research trends in necrotizing pancreatitis: a bibliometric analysis from 2013 to 2024.
  21. Research Progress and Trends in Exercise Interventions for Mild Cognitive Impairment: A Bibliometric Visualization Analysis Using CiteSpace.
  22. Global research progress and trends in traditional Chinese medicine for chronic kidney disease since the 21st century: a bibliometric analysis.
  23. The association between periodontal disease and adverse pregnancy outcomes: a bibliometric analysis from 2000 to 2023.
  24. 50 years of methylprednisolone application in spinal cord injury: a bibliometric analysis.
  25. A Bibliometric Analysis of the Integration of mHealth, Telemedicine, and OpenAI in Aesthetic Plastic Surgery: Advancements, Trends, and Future Directions.
  26. Bibliometric analysis of literature on natural medicines against chronic kidney disease from 2001 to 2024.
  27. A Decadal Bibliometric Analysis on the Therapeutic Strategies in Oral Lichen Planus.
  28. A bibliometric analysis of exosomes in aging from 2007 to 2023.
  29. Global incidence and trends of ocular cancer: A bibliometric analysis.
  30. Research trends of neoadjuvant therapy for breast cancer: A bibliometric analysis.
  31. Artificial intelligence in kidney transplantation: a 30-year bibliometric analysis of research trends, innovations, and future directions.
  32. Association between chronic obstructive pulmonary disease and osteoporosis: Mendelian randomization combined with bibliometric analysis.
  33. Web of Science-Based Visualization of Metabolic Dysfunction-Associated Fatty Liver Disease in Pediatric and Adolescent Populations: A Bibliometric Study.
  34. Bibliometric study of plastics microfluidic chip from 1994 to 2022: A review.
  35. Determinants of journal impact factors in 'Nutrition and Dietetics'.
  36. Global bibliometric analysis of traditional Chinese medicine regulating gut microbiota in the treatment of diabetes from 2004 to 2024.
  37. Advancements and future directions in chronic rhinosinusitis: understanding inflammatory mechanisms (2000-2023).
  38. Artificial Intelligence and Finance: A bibliometric review on the Trends, Influences, and Research Directions.
  39. Publication trends and green cosmetics buying behaviour: A comprehensive bibliometric analysis.
  40. Foot osteoarthritis research: A bibliometric analysis.
  41. Research Status and Development Trend of Greenhouse Gas in Wetlands: A Bibliometric Visualization Analysis.
  42. Publication Trends in The Journal of Shoulder and Elbow Surgery.
  43. Visualization Analysis of Tau Protein in the Brain of Alzheimer's Disease: A Scoping Literature Review.
  44. Global insights into MRSA bacteremia: a bibliometric analysis and future outlook.
  45. Massive covidization and subsequent decovidization of the scientific literature involved 2 million authors.
  46. The Impact of National Orthopaedic Fracture Registries: A Systematic Review.
  47. Publication Counts in Context: Normalization Using Query and Reference Terms in PubMed.
  48. Investigating the research landscape of chlorinated paraffins over the past ten decades.
  49. Editors' Selections from Relevant Scientific Publications.
  50. Educational background, professional experience, and research productivity of Canada's academic ophthalmology leadership.
  51. Deciphering Epigenetic and Post-Translational Modifications in Ferroptosis: A Scientometric and Visualization Study.
  52. Reimagining policy visibility: Bibliometric analysis of core nursing journals.
  53. National institutes of health: Analysis of gender differences in anesthesiology research funding.
  54. Methodological framework for supporting phytochemical bioprospecting re-search: A case study on carrot (Daucus carota L.) crop by-products.
  55. Research Trends and Dynamics in Single-cell RNA Sequencing for Musculoskeletal Diseases: A Scientometric and Visualization Study.
  56. A bibliometric analysis of hydrogel research in various fields: the trends and evolution of hydrogel application.
  57. Should premenstrual syndrome and premenstrual dysphoric disorder coexist in diagnostic manuals: Exploring the answer through citation analysis.
  58. Characteristics of Abstracts Presented at the American Academy of Orthopaedic Surgery Annual Meeting and Their Impact on Publication Rates.
  59. Evolutionary Trends and Research Focal Points on Port Wine Stains: A Scientometric and Meta-Analysis.
  60. Discussions on Human Enhancement Meet Science: A Quantitative Analysis.
  61. Bibliometrics of the current state of application of teletechnology in the rehabilitation of patients with heart and large blood vessel disease.
  62. A systematic literature review on digital literacy, employability, and innovative work behavior: emphasizing the contextual approaches in HRM research.
  63. Thousands of highly cited scientists have at least one retraction.
  64. Gender Diversity in the Editorial Boards of Global Obstetrics and Gynecology Journals.
  1. J Orthop. 2025 Sep;67 88-93
    The top 50 cited publications relating to femoral shaft fractures - A bibliometric analysis of the literature.
    Conor Medlar, Conor J Kilkenny, Martin S Davey, Fahad Farooq, Brendan J O'Daly.
       Background: Femoral shaft fractures (FSF's) represent common orthopaedic injuries, traditionally resulting from high-energy trauma in younger patients. Effective treatment is crucial for functional recovery, with significant social and economic implications. Despite extensive literature relating to FSF's, the quality of evidence and research trends remain unclear.
    Methods: A bibliometric analysis was conducted using Web of Science (August 2024) to identify the top 50 most-cited publications related to FSF's. Publications were screened using specific inclusion and exclusion criteria, focusing on primary FSF-related research. Data including authorship, publishing institution, level of evidence (LOE), and study focus were analysed using VOSviewer software to explore bibliometric coupling, co-citation relationships and keyword co-occurrences.
    Results: The 50 most-cited publications collectively received 9796 citations, with the highest cited paper accumulating 508 citations. Treatment outcomes (50 %) and epidemiology (32 %) were the predominant study focuses, while only 4 % addressed surgical techniques. Retrospective cohort and case-control studies constituted 84 % of the included papers, predominantly of level III evidence. The mean patient age was 37.96 years, with a majority being female (65.2 %). Hannover Medical School emerged as the most prolific institution, and the Journal of Bone and Joint Surgery published the highest number of articles. Co-occurrence analyses highlighted trends in osteoporosis and bisphosphonate-related FSFs.
    Conclusions: FSF literature has expanded, focusing primarily on treatment outcomes and epidemiological risk factors. However, a significant proportion of studies are of low evidence, with limited prospective research and an underrepresentation of topics such as FSF complications and paediatric fractures. Future studies should aim to maximise research quality and address emerging themes, including gender-specific analyses and the management of atypical fractures in elderly male populations.
    Keywords:  Bibliometric analysis; Femoral shaft fractures; Femur; Trauma; Treatment outcomes
    DOI:  https://doi.org/10.1016/j.jor.2025.01.025
  2. Front Psychiatry. 2024 ;15 1517508
    Anxiety disorders and the gut microbiota: a bibliometric and visual analysis.
    Linli Guo, Qin Ding, Qing Li, Danping Zheng, Linglin Guo, Xiaotao Cao, Qianqian Mou.
       Introduction: Anxiety disorder is a common mental illness, yet its specific mechanisms remain unclear. Recent research has revealed a connection between gut microbiota and anxiety disorders. This study aims to assess the current global research landscape, highlight current topics of interest, and explore future research directions in the field of anxiety disorders and gut microbiota.
    Methods: We extracted research review articles related to anxiety and gut microbiota from the Web of Science, covering the period from 2004 to 2023. We used VOSviewer 1.6.18.0, Scimago Graphica, and CiteSpace 6.2. R2 to visualize the contributions of countries, institutions, journals, authors, citations, and keywords in this field.
    Result: A total of 1198 articles were included in this bibliometric analysis. Over the past two decades, both publications and citations have shown a steady increase. China, the United States, and Canada were the top three countries in terms of publication output. John Cryan from University College Cork had the highest number of publications and citation impact in this area of research. The journal Nutrients had the highest number of publications, while Brain Behavior and Immunity had the most citations. Key research themes in recent years have included anxiety, gut microbiota, depression, stress, gut-brain axis, and probiotics, all of which are likely to be important future research directions.
    Conclusion: This analysis has key research areas and emerging trends, including risk factors, stressors, inflammatory responses, the gut-brain axis, and probiotics. These insights can guide researchers towards a more comprehensive understanding of recent advancements in this field, help shape future research directions and facilitate the identification of new therapeutic targets for anxiety disorder, ultimately improving clinical outcomes.
    Keywords:  anxiety disorder; bibliometrics; gut microbe; gut-brain axis; immunity
    DOI:  https://doi.org/10.3389/fpsyt.2024.1517508
  3. Front Neurol. 2024 ;15 1494936
    Influential publications in sudden hearing loss: a bibliometric and visual synopsis of the top 100 cited articles.
    Xueshi Di, Junjie Liang, Xinru Wang, Xue Bai, Chongyang Zhang, Ting Pan, Tiantian He, Peng Bai.
       Background: Sudden hearing loss (SHL) is a prevalent emergency in otolaryngology. Despite its frequency, there is a lack of econometric analysis and visualisation of the most significant SHL research literature. This study aims to provide a comprehensive overview and explore the characteristics of the 100 most cited articles in SHL through bibliometric analysis.
    Materials and methods: The Web of Science Core Collection (WOSCC) was used to identify the 100 most cited SHL articles from 1999 to 2024. Tools such as CiteSpace and VOSviewer were employed to visualise data on countries, institutions, authors, co-cited authors, journals, co-cited journals, co-cited references, and keywords.
    Results: The citations of the 100 most cited articles ranged from 59 to 760, with publications spanning from 1999 to 2021 and peaking in 2005. The most cited article was authored by Schwartz SR. The majority of these articles originated from the United States. Key themes identified include treatment options for SHL, with prominent keywords such as deafness, therapy, and dexamethasone.
    Conclusion: This study identified the highly cited literature in SHL research, revealing a primary focus on treatment options. These findings provide crucial insights into the research hotspots and frontiers in the field of SHL.
    Keywords:  bibliometrics; most cited articles; sudden hearing loss; treatment options; visual analysis
    DOI:  https://doi.org/10.3389/fneur.2024.1494936
  4. J Maxillofac Oral Surg. 2025 Feb;24(1): 15-23
    Exploring the Landscape of Salivary Gland Disorders: A Comprehensive Bibliometric Analysis.
    Furkan Ozbey, Omer Uranbey, Omer Faruk Kaygisiz, Elif Sadik, Ferhat Ayranci.
       Objective: This study aims to conduct a major bibliometric analysis of salivary gland disorders, exploring publication characteristics, trends, and influential contributors. The primary objective is to improve understanding of the current state of research in this area and to identify potential directions for future investigation.
    Methods: A comprehensive study was conducted analysing 11,679 publications from 1980 to 2023 retrieved from the Web of Science Core Collection. The analysis included collaboration across countries, keyword co-occurrence, co-citation networks and clustering. CiteSpace and VOSviewer were used to explore relationships and create visualisations.
    Results: The analysis revealed a dynamic landscape of salivary gland research, with the United States leading in both the number of publications (n = 2998) and centrality (0.26). Network analysis unveiled nine clusters, including topics such as parotidectomy and immunohistochemistry. Co-occurrence analysis of keywords highlighted evolving trends, with recent emphasis on terms such as sialendoscopy, cytopathology, and gene fusion. The timeline view illustrated the changing significance of terms over the years, reflecting current areas of interest such as radiomics and mucoepidermoid carcinoma.
    Conclusion: This study provides a comprehensive overview of the field, offering insights into influential work, collaborative networks, and emerging trends. The outputs of the analysis can guide researchers and clinicians in shaping future investigations.
    Keywords:  Bibliometric analysis; Mapping analysis; Salivary gland
    DOI:  https://doi.org/10.1007/s12663-024-02211-7
  5. Heliyon. 2025 Jan 30. 11(2): e42080
    Research trends and network approach of critical thinking skills in English Language Teaching - A bibliometric analysis implementing R studio.
    M P Arthi, S N S Gandhimathi.
      Critical thinking is often regarded as one of the vital skills in the 21st century. In recent years, it has become important to combine this skill with other skills such as language learning, creativity, problem-solving, decision making, and reflective thinking. As language and thoughts are intertwined and influence each other, incorporating thinking skills into English Language Teaching (ELT) can enhance academic and professional success. The prime objective of the current study is to conduct a bibliometric analysis of research on Critical Thinking (CT) in ELT from 2012 to 2022 by focusing on publication and research trends such as influential authors, globally cited documents, pertinent journals, leading countries, and significant affiliations. The current study also sheds light on the co-occurrence of keywords and thematic evolution through bibliometric analysis, examining 238 articles from Scopus and Web of Science databases using R studio (Biblioshiny). This bibliometric analysis highlights Thinking Skills and Creativity as the most pertinent journal with high citation count and China being the most cited country in this field. It also accentuates the interconnection between higher-order thinking skills, self-regulation, critical thinking, and critical reading. The thematic evolution of CT shows a shift from collaborative learning and CT (2012-2019) to language teaching and CT (2020-2022). It emphasizes the importance and the rising prominence of CT skills in language teaching. Moreover, this review will guide scholars and academicians to identify future research directions in the field of CT.
    Keywords:  Bibliometric analysis; Biblioshiny; Critical thinking; English language teaching; R studio
    DOI:  https://doi.org/10.1016/j.heliyon.2025.e42080
  6. Front Med (Lausanne). 2024 ;11 1488796
    Bibliometric analysis of pyroptosis in pathogenesis and treatment of acute lung injury.
    Chun Wang, Na Liu.
       Objective: This study aims to conduct a bibliometric analysis to assess the present state, thematic focus, and emerging developments in the research literature on the involvement of pyroptosis in the pathogenesis and treatment of acute lung injury (PFALI), as well as other pertinent research areas.
    Methods: This bibliometric study examined PFALI research published from 1 January 2004 to 24 May 2024, utilizing the Web of Science database. The analysis was conducted using CiteSpace, VOSviewer, R, and GraphPad Prism 8.0, and encompassed metadata on the countries, institutions, authors, journals, and keywords represented in the literature.
    Results: This study analyzed 1,495 publications, comprising 1,194 articles and 301 reviews, to assess the publication output on PFALI. China exhibited the highest output with 964 (64.48%) articles. Central South University was the most prolific institution, contributing 54 (3.61%) publications. Zhou, Yong had the greatest individual publication record, with 15 (3.59%) articles. The journal International Immunopharmacology published the most PFALI-related articles at 76 (5.09%). The identified research frontiers for upcoming years include "iron," "sirt1," "repair," and "alveolar macrophage pyroptosis."
    Conclusion: This bibliometric analysis comprehensively examined research trends and advancements related to PFALI, including the contributions of key authors, institutions, and countries.
    Keywords:  Nrf2 signaling pathway; acute lung injury; inflammasome; pyroptosis; targeted therapy
    DOI:  https://doi.org/10.3389/fmed.2024.1488796
  7. J Clin Orthop Trauma. 2025 Apr;63 102917
    Trends of publications on primary sarcomas of bone: A bibliometric analysis.
    Vibhu Krishnan Viswanathan, Mohit Kumar Patralekh, Vijay Kumar Jain, Madhan Jeyaraman, Abdus Sami, Karthikeyan P Iyengar, Rajesh Botchu.
       Introduction: Sarcomas are a large group of malignant mesenchymal tumors. Despite being rare diseases, the disease burden of these malignant tumors on the existing healthcare infrastructure is substantial. Although previous bibliometric studies have analyzed the trends of publications on osteosarcoma and Ewing's sarcoma, no such major analyses encompassing all primary bone sarcomas have been reported hitherto.
    Materials and methods: A cross-sectional, bibliometric study of the published literature on bone sarcoma was performed on the Web of Science (WoS) database (Clarivate analytics) on the March 25, 2024. Only the manuscripts with a focus on primary sarcoma of bone published between 1945 and 2024 and articles in the English language were included. Diverse details regarding the publication trends (such as top authors, journals, countries, etc.) and citation profiles (mean annual citations, H-index, etc.) of the included studies were tabulated. Based on the bibliographic data, keyword, and co-authorship mappings were performed using the VOSviewer.
    Results: A total of 3541 articles were included in the bibliometric analysis. The top three most-published authors were Hornicek FJ (n = 58), Henery Mankin (n = 53), and Unni K Krishnan (n = 43). The top three institutions publishing research on primary bone sarcoma were Mayo Clinic Hospital, USA (n = 162), Harvard University, USA (n = 146), and Massachusetts General Hospital, USA(n = 116) . The top three countries contributing to research on primary bone sarcoma were the USA (n = 1129), China (n = 402), and Japan (n = 385). CORR (n = 578), Skeletal Radiology (n = 430), and JBJS-Am (n = 228) were the most common journals publishing research on this subject. Overall, there has been a progressive upsurge in global publication rates, especially since 2009 (with a mean publication rate of 100-120). The rate of citations of publications on bone sarcomas has also followed a similar pattern of consistent growth during the past years, with a mean annual citation rate ranging between 4000 and 5000.
    Conclusion: Based on our bibliometric study, there has been substantial growth in the published research on bone sarcomas over the past 2 decades. Concomitantly, the impact of these publications has also significantly increased across the globe over the past years. A majority of the contributions have originated from the USA, China, and Japan; with a high number of institutions and authors from these nations dominating in terms of the overall quantity of publications and citations on this subject. Our observations highlight the critical need for improved academic communications as well as a robust, international cooperative strategy to meliorate the research outputs on bone sarcoma.
    Keywords:  Bibliometrics; Bone; Malignant; Sarcoma
    DOI:  https://doi.org/10.1016/j.jcot.2025.102917
  8. Front Immunol. 2025 ;16 1511827
    Recent trends in research on the role of cholesterol in leukemia: a bibliometric and visualization study.
    Huijuan Lv, Ke Lu, Ximing Wang, Yanfang Zhang, Mengqi Zhuang, Jing Li, Keli Su, Wen Gao.
       Background: Cholesterol metabolism significantly impacts leukemia pathophysiology, affecting tumor cell survival, proliferation, and treatment resistance. This study employs bibliometric analysis and visualization techniques to investigate research trends regarding cholesterol in leukemia and identify key hotspots.
    Methods: A systematic search of the Web of Science Core Collection was performed for literature published from 1980 to 2024 using the keywords "cholesterol" and "leukemia," yielding 1,220 articles. Bibliometric tools like VOSviewer and CiteSpace were utilized for visualizing citation networks and thematic clusters.
    Results: The analysis comprised 1,220 publications produced by 6,771 researchers across 1,756 institutions in 68 countries, published in 576 journals with 5,903 unique keywords. Publication output demonstrated a significant rise from 1980 to 2024, peaking in 2022. The United States led in total publications (381) and citations (40,462), followed by China (137 articles) and Japan (102). Notably, U.S. publications had lower average citations than those from Germany and Brazil. Key institutions included the University of São Paulo, Medical College of Wisconsin, and National Cancer Institute, with prominent authors such as Maranhao Raul C. and Girotti Albert W. The journal Cancer Research was the most prolific, while Blood had the highest citation frequency. Major research areas encompassed molecular biology, immunology, and medicine, focusing on the cholesterol-leukemia link. Keyword co-occurrence and co-citation analyses reveal increasing interest in topics like STAT3, multidrug resistance, and treatment interactions. These insights suggest crucial areas for further research.
    Discussion: Our findings emphasize cholesterol's significance in leukemia, indicating its potential as a therapeutic target. Further exploration at the intersection of cholesterol metabolism and leukemia requires multidisciplinary collaboration.
    Conclusion: This bibliometric study delineates the evolving research landscape on cholesterol's role in leukemia, pinpointing emerging trends and future research directions to inform effective therapeutic strategies.
    Keywords:  Web of Science; bibliometric analysis; cholesterol; hot spots; leukemia; trend
    DOI:  https://doi.org/10.3389/fimmu.2025.1511827
  9. J Orthop. 2025 Aug;66 84-91
    Global trends in proximal femoral trabecular research: A bibliometric and visualized analysis.
    Peng Jia, Yi Yang, Xin Tang.
       Introduction: Hip disease is a global public health issue, associated with high morbidity, mortality, and healthcare costs. Although research on proximal femoral trabeculae has been conducted for over a century, no bibliometric analysis has been carried out. The purpose of this study is to evaluate the existing research landscape, identify emerging trends, and offer insights for future studies.
    Method: The scientific output related to the trabeculae within the human proximal femur from 2004 to 2023 was sourced from the Web of Science Core Collection. Moreover, both the annual publications and cumulative totals over this period were summarized in Excel. The VOS viewer was utilized to analyze co-authorship and co-citation relationship between authors, institutions, countries, references and journals. CiteSpace was used to cluster the keywords and research frontiers in this field.
    Results: A total of 365 publications were extracted, with the USA emerging as the primary contributor to this field, accounting for 133 publications with 5807 total citations, averaging 43.7 citations per publication. The Journal of Bone and Mineral Research has been identified as the most co-cited journal with a total of 1742 citations. The journals can be categorized into 5 distinct clusters, including medical imaging, orthopedic clinical research, research on endocrine and metabolic related diseases, human evolution and anatomy related research, biomechanics and modeling. The keyword with the highest co-occurrence frequency is "bone mineral density". The keywords were stratified into six clusters, including DXA, bone remodeling, diagnosis, titanium alloy bionic cannulated screws, individual trabecula segmentation, and QCT. More recently, the focus has expanded to three-dimensional modeling, falls, microarchitecture, and avascular necrosis.
    Conclusions: Evaluation of proximal femoral strength can be improved by combining structural parameters with bone mineral density by DXA or QCT. Three-dimensional analysis, microarchitecture, and bionic implants are emerging as significant areas of focus and trends for future research.
    Keywords:  Bibliometrics analysis; CiteSpace; Proximal femur; Trabecular bone; VOSviewer
    DOI:  https://doi.org/10.1016/j.jor.2025.01.009
  10. Front Neurol. 2024 ;15 1474353
    Evolution in optical molecular imaging techniques guided nerve imaging from 2009 to 2023: a bibliometric and visualization analysis.
    Wenkai Liang, Yan Liu, Erlong Jia, Xiaofeng Yang, Shufeng Han, Jinzheng Wei, Wei Zhao.
       Background: Recent years, the use of optical molecular imaging (OMI) techniques guided nerve imaging has made significant progress. However, a comprehensive bibliometric analysis in this field is currently lacking. In this study, we aim to shed light on the current status, identify the emerging hot topics, and provide valuable insights for researchers within this field.
    Methods: In this study, we collected 414 research via the Web of Science Core Collection (WoSCC) from 2009 to 2023. CiteSpace, VOSviewer and R package "bibliometrix" were used for analysis of countries, institutions, journals, etc., to evaluate the trends.
    Results: The amounts of publications in relation to OMI guided nerve imaging has been increasing. United States and China contributed to over 60% of the publications. The Shanghai Jiao Tong University contributed the highest number of publications. Investigative Ophthalmology and Visual Science is considered the most prestigious and prolific journal in the field. It is also widely regarded as the most cited journal. Among the top 10 authors in terms of output, Hehir CAT has the highest number of citations. The "neurosciences neurology," "science technology other topics," and "ophthalmology" are representative research areas. The main cluster of keywords in this field includes "axonal regeneration," "mouse," and "optical coherence tomography."
    Conclusion: This bibliometric investigation offers a comprehensive portrayal of the structure of knowledge and the progression patterns, presents an all-encompassing synthesis of findings, discerns and illustrates the forefront within OMI guided nerve imaging for the first time. It will provide a valuable reference for relevant scholars.
    Keywords:  bibliometric; fluorescence guided surgery; nerve imaging; optical molecular imaging techniques; web of science
    DOI:  https://doi.org/10.3389/fneur.2024.1474353
  11. Front Neurol. 2024 ;15 1448990
    Global trends in migraine and anxiety over the past 10 years: a bibliometric analysis.
    Biao Huang, Weining Chen, Chunmei Peng, Yu Wang, Xiuli Shen, Qi Zhang, Liu Yang, Jun Wu.
       Background: Recent studies have shown that migraine significantly increases the incidence of anxiety and is positively correlated with the severity and frequency of migraine. The relationship between migraine and anxiety has attracted extensive attention. This study focused on the association between migraine and anxiety, aiming to predict potential future research trends.
    Methods: A bibliometric analysis was conducted using publications from the Core Collection of Web of Science. We utilized CiteSpace.5.8.R3 and VOSviewer 1.6.17 to evaluate the value of articles over the past 10 years.
    Results: The number of publications has increased significantly over the past 10 years. The cooperative network analysis shows that the United States is the most collaborative country. Additionally, Harvard University is the institution and Richard B. Lipton the individual with the highest number of studies on migraine. The analysis of keyword outbreaks indicates that the strong citation burst words are closely related to sex differences, activation, allodynia, and preventive treatment, which represent emerging new research areas and potential hotspots for future research.
    Conclusion: An overall upward trend in the research of migraine and anxiety was observed. Sex differences, functional magnetic resonance imaging (fMRI), activation, allodynia, and preventive treatment are predicted to be hotspots in the future.
    Keywords:  anxiety; bibliometric analysis; global research trends; migraine; visualization
    DOI:  https://doi.org/10.3389/fneur.2024.1448990
  12. Psychophysiology. 2025 Feb;62(2): e70002
    Mapping 60 Years of Psychophysiology: A Bibliometric Analysis of Journal Performance, Authorship Trends, and Thematic Evolution.
    Christian Panitz, Carola Dell'Acqua.
      Psychophysiology, the flagship journal of psychophysiological research, has played a key role in the field for 60 years. For the present study, we conducted a bibliometric analysis assessing the journal's development in terms of performance, authorship trends, and thematic content for this time span. Over the years, Psychophysiology has experienced a consistent increase in manuscript submissions, published articles, and impact factor. Authorship trends showed larger, more diverse author teams, with a growing percentage of female first authors now representing about 50% of submissions and an increase in international collaborations. Thematic content has evolved, shifting from peripheral measures to central nervous system measures like EEG and ERPs while maintaining the journal's long-standing emphasis on methodological advancements. Research topics have expanded from basic stimulus processing to more complex investigations into emotion, cognition, and psychopathology, with growing interdisciplinary integration. This article provides a quantitative overview of Psychophysiology's contributions and development, aimed at offering insights into the journal's past, current state, and potential future directions in psychophysiological research.
    Keywords:  authorship; bibliometric review; bibliometrix; journal performance; psychophysiology; thematic development
    DOI:  https://doi.org/10.1111/psyp.70002
  13. Front Neurol. 2024 ;15 1498576
    Research hotspots and trends of acupoint and pain based on PubMed: a bibliometric analysis.
    Zhulin Wu, Wanjun Tan, Siyi Li, Weiqing Zhang, Mingbo Lai, Weijun Luo.
       Objective: Acupoint-related interventions are the widely utilized modalities in traditional Chinese medicine for the alleviation of pain. This study aims to identify research hotspots and trends by conducting a bibliometric analysis of the relevant literature on acupoint and pain, thereby elucidating future research directions in this field.
    Method: A comprehensive search was conducted on PubMed for literature pertaining to acupoint and pain from January 2010 to August 2024. Subsequent bibliometric analyses, encompassing statistical evaluation of bibliographic data, keyword cluster analysis, and co-occurrence analysis, were conducted utilizing the Medpulse database and the Bibliometrix R-package.
    Results: A total of 742 articles from 179 journals were included in the analysis, with the majority focusing on complementary and alternative medicine or comprehensive research. The number of publications in this field has shown a consistent annual increase, involving contributions from 19 different countries of corresponding authors. China had the greatest contribution with 407 articles followed by Korea with 25 articles. The leading institutions in terms of publication volume are Chengdu University of Traditional Chinese Medicine, China Medical University, and Kyung Hee University. The topics covered in these articles include acupuncture, transcutaneous electrical acupoint stimulation (TEAS), randomized controlled trials, analgesia, zusanli (st36), systematic review, and anxiety, among others. The main cluster themes are intervention methods for various acupoints and the assessment of their efficacy.
    Conclusion: The bibliometric analysis has identified the intervention methods of acupoints and the evaluation of their efficacy in pain management as emerging research focal points. Additionally, anxiety is anticipated to emerge as a future research direction within this domain.
    Keywords:  acupoints; acupuncture; bibliometrics; pain; transcutaneous electrical acupoint stimulation
    DOI:  https://doi.org/10.3389/fneur.2024.1498576
  14. Vet World. 2024 Dec;17(12): 2763-2773
    Trends in camel research in South Asia: A bibliometric approach.
    Mahmoud Kandeel.
       Background and Aim: Camels play a crucial role in South Asia's cultural, economic, and ecological landscape. This study aimed to conduct a systematic bibliometric analysis of camel research from South Asia. This study sought to provide an overview of the topic's development and current and evolving themes by examining publication patterns, citation metrics, authorship trends, and thematic evolutions.
    Materials and Methods: The data for this study were obtained from the Scopus database. Bibliometric analysis was conducted using VOSviewer and the Bibliometrix package in R Studio to analyze publication trends, author productivity, collaboration patterns, journal impacts, keyword analyses, institutional contributions, and research outputs from individual countries.
    Results: The bibliometric analysis of camel research in South Asia identified 1106 documents from 320 sources involving 2443 authors, with an international coauthorship rate of 16.91%. The primary clusters of research topics were camel biology and the veterinary sciences, focusing on the biological and health aspects of camels; camel milk and its products, emphasizing the role of camel milk in human nutrition and health; the genetics and molecular biology of camels; the pathogens and diseases of camels and their control; camel tissues and structures; and the effects of camel products on human health. India and Pakistan are the leading sources of such articles. Trending and evolving topics in camel research in South Asia continue to increase, forming a dynamic landscape. Key themes include growing interest in camel products' nutritional and therapeutic properties, particularly camel milk and bioactive compounds. The antioxidant and anti-inflammatory properties of camel products and their bioactive peptides have also gained research attention. The evolution from traditional studies of camel physiology and disease to molecular and genomic research underscores a shift toward a more detailed, mechanistic understanding of camel biology and health.
    Conclusions: This bibliometric study highlighted the significant growth and diversification of camel research in South Asia over the past decades. The study emphasized the need for continued support and collaboration to gain knowledge of the unique attributes of camels and their regional and global benefits.
    Keywords:  South Asia; bibliometric analysis; camel research; publication trends
    DOI:  https://doi.org/10.14202/vetworld.2024.2763-2773
  15. J Multidiscip Healthc. 2025 ;18 531-547
    Research Hotspots and Trends in Acupuncture for Cancer:A bibliometric analysis from 2004 to 2024.
    Zhe Ji, Heyuan Niu, Anqi He, Kaiyu Li, Jinyan Jia, Maorun Zhang, Gang Liu.
       Background: Acupuncture is increasingly recognized as a promising intervention modality in cancer treatment. Nevertheless, there has been a paucity of systematic analysis and visualisation of relevant publications through bibliometric methods. This paper conducts a bibliometric analysis of research on acupuncture within the realm of oncological applications, aiming to explore its prospects and emerging trends.
    Methods: In this study, we analyzed 2117 documents obtained from the Web of Science Core Collection (WOSCC) to examine the correlations among authors, journals, institutions, countries, and keywords. This analysis was conducted using the Bibliometric R package, CiteSpace, and VOSviewer software.
    Results: The evolution of acupuncture can be broadly divided into three time periods: 2004-2008, 2009-2017 and 2018-2024. The WOSCC retrieved 2117 publications on acupuncture for cancer over the past 20 years. Among the top 10 institutions, seven were from the United States, two from China, and one from Korea. Memorial Sloan Kettering Cancer Center had the highest number of publications. At the same time, the journal INTEGRATIVE CANCER THERAPIES published the most articles in this field. Keyword co-occurrence analysis revealed four distinct clusters: "Alternative and Complementary Medicine for Cancer", "Acupuncture for cancer-related fatigue and pain", "Acupressure for anxiety, depression, and insomnia", "Improving quality of life for breast cancer patients". The most recent keyword outbreaks included "sleep", "radiation induced xerostomia", "recovery", "insomnia", and "induced peripheral neuropathy." Breast cancer is the type of cancer for which acupuncture is most commonly used.
    Conclusion: The future research focus will be on acupuncture as a treatment for sleep disorders, the alleviation of radiotherapy complications and the improvement of postoperative quality of life. Research on acupuncture in the field of breast cancer is more extensive compared to other cancers. Therefore, it is necessary to strengthen research on acupuncture in different cancer types.
    Keywords:  VOSviewer; acupuncture; bibliometric analysis; cancer; citespace
    DOI:  https://doi.org/10.2147/JMDH.S494138
  16. Telemed J E Health. 2025 Feb 07.
    Advancements in Telemedicine for Surgical Practices: A Comprehensive Bibliometric Analysis.
    Runang Ding, Dongmei Zhuang, Xinyu Zuo, Wenzhuo Wei, Lijun Ma, He Du, Anran Jin, Xiaoming Li.
      Purposes: This study aims to use bibliometric analysis to explore the development, research hotspots, and trends in the field of telemedicine for surgical practices (TSPs). Methods: A bibliometric analysis of 3,235 documents from the Web of Science Core Collection was conducted, spanning from 2004 to 2022. Citespace (6.2.R5) was used to perform a bibliometric analysis. Results: The findings highlight a marked escalation in researches of TSPs, particularly between 2019 and 2022, aligning with the COVID-19 pandemic. The Telemedicine and e-Health Journal was the most productive journal with 118 publications, and Journal of Telemedicine and Telecare had the most citations (n = 700). Howard S. An and Mohammad El-sharkawi had the most papers (n = 8). Harvard University was the most prolific institution (n = 103). The United States, England, and Canada were identified as the predominant contributing countries with a total of 1,521 publications. There was a notable shift in research focus areas over time, with recent emphasis being placed on pediatric surgery, COVID-19-related studies, and orthopedics. Future trends may involve teleconsulting, ameliorating the quality and safety of telemedicine, and improving satisfaction levels of patients and caregivers when they are using telemedicine. Conclusions: The study reveals that the rapid and sustained advancement in TSPs, significantly driven by the COVID-19 pandemic, and huge gaps between developed countries and developing countries. This study also reflects the current hotspots and future directions for TSPs.
    Keywords:  COVID-19; bibliometric; surgery; telemedicine
    DOI:  https://doi.org/10.1089/tmj.2024.0455
  17. Front Mol Biosci. 2025 ;12 1538743
    Global trends and emerging insights in BRAF and MEK inhibitor resistance in melanoma: a bibliometric analysis.
    Jianhao Bai, Zhongqi Wan, Wanru Zhou, Lijun Wang, Wei Lou, Yao Zhang, Haiying Jin.
       Objective: This study aims to perform a comprehensive bibliometric analysis of global research on BRAF and MEK inhibitor resistance in melanoma, identifying key research trends, influential contributors, and emerging themes from 2003 to 2024.
    Methods: A systematic search was conducted in the Web of Science Core Collection (WoSCC) database to retrieve publications related to BRAF and MEK inhibitor resistance from 1 January 2003, to 1 September 2024. Bibliometric analyses, including publication trends, citation networks, and keyword co-occurrence patterns, were performed using VOSviewer and CiteSpace. Collaborative networks, co-cited references, and keyword burst analyses were mapped to uncover shifts in research focus and global cooperation.
    Results: A total of 3,503 documents, including 2,781 research articles and 722 review papers, were analyzed, highlighting significant growth in this field. The United States, China, and Italy led in publication volume and citation impact, with Harvard University and the University of California System among the top contributing institutions. Research output showed three phases of growth, peaking in 2020. Keyword and co-citation analyses revealed a transition from early focus on BRAF mutations and MAPK pathway activation to recent emphasis on immunotherapy, combination therapies, and non-apoptotic cell death mechanisms like ferroptosis and pyroptosis. These trends reflect the evolving priorities and innovative approaches shaping the field of resistance to BRAF and MEK inhibitors in melanoma.
    Conclusion: Research on BRAF and MEK inhibitor resistance has evolved significantly. This analysis provides a strategic framework for future investigations, guiding the development of innovative, multi-modal approaches to improve treatment outcomes for melanoma patients.
    Keywords:  BRAF mutations; MEK inhibitors; immunotherapy; melanoma; therapeutic resistance
    DOI:  https://doi.org/10.3389/fmolb.2025.1538743
  18. Hum Vaccin Immunother. 2025 Dec;21(1): 2459459
    Profile of Chlamydia vaccine research: A bibliometric analysis.
    Xuemei Wang, Qian Wang, Yidan Gao, Lijuan Jiang, Lingli Tang.
      Vaccination is the most effective measure to prevent Chlamydia infection. However, to date, no vaccine has successfully completed the rigorous clinical trial process and gained regulatory approval for use in clinical practice. Scholars have been working on a safe and effective Chlamydia vaccine. In order to better grasp, the global frontiers and development trends in this field, a comprehensive bibliometric analysis was carried out. A total of 234 publications closely regarding Chlamydia vaccines were culled from the Web of Science Core Collection database, and the bibliometric information was then extracted with CiteSpace and VOSviewer software. After measurement analysis, the most influential papers were identified in this area, including highly cited papers, references with strong citation burst, and high co-citated papers. Vaccine has published the most literature on Chlamydia vaccines. Only scholars from 39 countries/regions have been engaged in studying Chlamydia vaccines. The USA is the most prolific country and has the highest collaborative strength. The current research area has focused on protective immunity and immunopathological response. Major outer membrane protein (MOMP) is the most common target vaccine antigen. This study reveals the status of literature and highlights emerging trends in this field, which helps researchers seek insights into this area and serve as a reference guide for further investigations.
    Keywords:  Chlamydia; CiteSpace; MOMP; Vosviewer; bibliometric; vaccine
    DOI:  https://doi.org/10.1080/21645515.2025.2459459
  19. J Multidiscip Healthc. 2025 ;18 473-492
    From Night to Light: A Bibliometric Analysis of the Global Research Trajectory of Sleep Disorders in Parkinson's Disease.
    Luya Shi, Xinxin Zhao, Jing Wu, Caidi He.
       Purpose: Sleep disorders are prevalent non-motor symptoms in patients with Parkinson's disease (PD), significantly diminishing the overall quality of life for patients and potentially accelerating the deterioration of motor and cognitive functions, accelerating disease progression. Despite increasing research on sleep disorders in PD, a comprehensive analysis of the knowledge structure and key issues in this field are still lacking. This study aims to identify research hotspots and emerging trends related to sleep disorders in PD through a detailed bibliometric analysis.
    Patients and Methods: On October 1, 2024, an extensive search was conducted in the Web of Science Core Collection (WOSCC) database to gather relevant literature on sleep disorders in PD. Bibliometric and knowledge mapping analyses were performed using CiteSpace, VOSviewer, and bibliometrix.
    Results: Between January 1, 2004, and October 1, 2024, a total of 3,655 publications on sleep disorders in PD were published by 3,387 institutions across 87 countries. The volume of publications has shown a steady increase, a trend projected to continue. Current research is primarily centered on Neurosciences, Pharmacology, and Clinical Neurology. Emerging trends involve comprehensive evaluations of sleep, early diagnosis and prevention of various sleep disorder subtypes in PD, and advancing research through animal models to develop effective therapies. Emerging keywords include machine learning, sleep quality, biomarkers, covid-19, and mouse model.
    Conclusion: This bibliometric analysis sheds light on the global landscape of PD-related sleep disorder research over the past two decades, highlighting key countries, institutions, authors, and journals driving advancements in the field. Moreover, it uncovers pivotal research hotspots and emerging trends, offering valuable insights and guidance for scholars engaged in this area.
    Keywords:  CiteSpace; Parkinson’s disease; REM sleep behavior disorder; bibliometric analysis; restless leg syndrome; sleep disorder
    DOI:  https://doi.org/10.2147/JMDH.S503849
  20. Front Med (Lausanne). 2025 ;12 1515418
    Global research trends in necrotizing pancreatitis: a bibliometric analysis from 2013 to 2024.
    Gulnur G Gainollina, Murat K Jakanov, Bazylbek S Zhakiev, Uteugaly G Karsakbayev, Kairat R Taishibayev, Bulat A Kurmanbayev.
       Background: This study aims to analyzing scientific publications related to necrotizing pancreatitis and its mortality, identifying key areas and trends, and determining the leading research institutions, authors, countries, and journals actively working in this field.
    Methods: The Web of Science and Scopus databases were searched for articles on NP published between January 1, 2013, and April 22, 2024. Articles published before 2013, conference abstracts, and case reports were excluded. The articles were assessed based on various metrics, including the number of citations, publication dates, countries of origin, institutions, journals, and authors.
    Results: A total of 929 articles were identified, of which 251 were deemed suitable for analysis after duplicates were removed. China contributed the most articles, followed by the United States and India. The most frequent publications appeared in specialized journals such as "Pancreatology" and "Journal of Gastrointestinal Surgery." The primary research institutions were universities and medical centers. The highest-impact articles focused on minimally invasive treatment methods for NP. There has been a growing body of research in NP over the past decade, particularly in China and the United States.
    Conclusion: Despite advancements in medical science, the mortality rate associated with pancreatic necrosis remains high. This highlights the continued challenge in effectively addressing complications of acute pancreatitis. Researchers worldwide are actively exploring alternative therapeutic approaches to mitigate these complications and improve patient outcomes.
    Keywords:  acute pancreatitis; bibliometric analysis; mortality; necrotizing pancreatitis; pancreatic necrosis
    DOI:  https://doi.org/10.3389/fmed.2025.1515418
  21. J Multidiscip Healthc. 2025 ;18 505-529
    Research Progress and Trends in Exercise Interventions for Mild Cognitive Impairment: A Bibliometric Visualization Analysis Using CiteSpace.
    Qifeng Han, Sung Min Kim.
       Purpose: With the increasing global aging population, exercise interventions for mild cognitive impairment (MCI) have gained significant research attention. This study uses CiteSpace6.3R2 to systematically analyze the research progress and emerging trends in this field.
    Methods: A comprehensive literature search in the Web of Science Core Collection focused on exercise interventions for MCI. After screening, 420 relevant publications were imported into CiteSpace6.3R2 for bibliometric analysis, generating visual maps of keywords, authors, institutions, and other key indicators.
    Results: Publications on exercise interventions for MCI have shown steady growth, with Journal of Alzheimer's Disease leading in volume, and Geriatrics & Gerontology as the dominant subject area. The USA ranks highest in collaborative output, with the Chinese University of Hong Kong as the top institution. Among authors, Shimada Hiroyuki and three Japanese colleagues are key contributors, while Neurology is the most frequently co-cited journal. The most frequently co-cited author, Petersen, R.C. has his 2018 work as the top reference. High co-occurrence keywords include "mild cognitive impairment", "dementia", and "Alzheimer's disease". The primary keyword clusters are #0 Cognitive training, #1 Cognitive impairment, and #2 Mild Cognitive impairment, while newly burst keywords "systematic review", "recommendations", and "depression".
    Conclusion: Research on exercise interventions for MCI has been steadily gaining attention, becoming an interdisciplinary research area in fields such as geriatrics and neuroscience, with relevant findings concentrated in specific journals. In the collaboration network, developed countries dominate, showing systematic patterns of inter-institutional collaboration, while author collaborations are primarily focused within institutions. Current research is centered on the design and mechanisms of exercise intervention programs. Future studies will prioritize integrated intervention strategies, systematic evidence synthesis, and personalized interventions for specific populations.
    Keywords:  CiteSpace; bibliometric; cognitive dysfunction; exercise intervention; exercise therapy; mild cognitive impairment; visualization analysis
    DOI:  https://doi.org/10.2147/JMDH.S498190
  22. Front Med (Lausanne). 2024 ;11 1480832
    Global research progress and trends in traditional Chinese medicine for chronic kidney disease since the 21st century: a bibliometric analysis.
    Heyong Wang, Jun Wang, Yang Chen, Dianxing Yang, Lanyue Xiong.
       Objective: This study analyzed literature on traditional Chinese medicine (TCM) in treating chronic kidney disease (CKD) to identify research trends and provide guidance for future studies and clinical practice.
    Methods: The study used data from Web of Science from 2000 to 2024 to analyze English-language literature on CKD and TCM. Bibliometric analysis was done using R software and the bibliometric package, with scientific mapping and visualization analysis conducted using tools like Citespace, VOSviewer, and ScimagoGraphica to explore research trends and connections.
    Results: This study revealed that a total of 1,153 relevant documents were retrieved, and the number of published articles showed an increasing trend, reaching a peak in 2022. In terms of article publication, China ranked first with 760 articles, closely followed by the United States with 132 articles. Guangzhou University of Traditional Chinese Medicine published 60 papers, the most among academic institutions, followed by Shanghai University of Traditional Chinese Medicine with 54 papers. In terms of individual authors, Liu Xinhui holds the record for the highest number of published articles, totaling 17, followed by Li Ping and Li Shunmin. The prevalent keywords include "chronic kidney disease," "TCM," and "oxidative stress." Currently, the prominent areas of research interest include network pharmacology, gut microbiota, oxidative stress, and related topics. The current research trend in this field is towards the adoption of novel methodologies such as network pharmacology and the emphasis on exploring the relationship between gut microbiota and CKD.
    Conclusion: Global research on TCM in the treatment of CKD is showing a positive development trend, but further research on safety, efficacy evaluation, and international cooperation is still needed. The development trend is to adopt new scientific research methods and focus on exploring the mechanism of TCM in treating CKD.
    Keywords:  chronic kidney disease; gut microbiota; network pharmacology; oxidative stress; traditional Chinese medicine
    DOI:  https://doi.org/10.3389/fmed.2024.1480832
  23. Front Med (Lausanne). 2025 ;12 1526406
    The association between periodontal disease and adverse pregnancy outcomes: a bibliometric analysis from 2000 to 2023.
    Miaomiao Zhao, Haoxiang Chang, Yuxu Yue, Xinyue Zeng, Shaobang Wu, Xiuyun Ren.
       Background: Periodontal disease (PD) refers to a chronic inflammatory disorder affecting the supporting tissues of the teeth triggered by bacterial infection and is recognized to promote systemic inflammation, leading to dysfunction in specific organs. Adverse pregnancy outcomes (APOs), including preterm birth, small for gestational age infants, gestational diabetes and preeclampsia, are linked to pregnancy complications. Recently, the correlation between periodontal disease and adverse pregnancy outcomes has garnered global attention. However, bibliometric studies in this area remain limited. This study aimed to visualize knowledge framework and research trends concerning the relationship between periodontal disease and adverse pregnancy outcomes from 2000 to 2023 through bibliometric approaches.
    Methods: On September 22, 2024, articles and reviews on the connection between periodontal disease and adverse pregnancy outcomes were retrieved from the Web of Science Core Collection (WOSCC). CiteSpace [6.3.R1 (64-bit) Advanced] was used to perform knowledge mapping and bibliometric studies.
    Results: Over the past 23 years, 932 articles from 73 countries were collected, with the U.S. contributing over one-third (355), followed by Brazil (85) and India (59). The literature in this field has experienced multiple growth phases since 2000, with particularly rapid growth observed after 2019. The University of North Carolina (n = 34, 3.65%) is the leading institution in terms of publication output, primarily representing the U.S. Notably, the Journal of Periodontology and the American Journal of Obstetrics and Gynecology are the most frequently cited journals in the fields of periodontology and obstetrics, respectively. These publications are authored by 94 researchers, with Steven Offenbacher being both the most productive and most highly cited author, making significant contributions to the field. A visual analysis of keywords identifies "oral microbiota," "oral health," "adverse pregnancy outcomes," and "global burden" as emerging research hotspots in exploring the correlation between periodontal disease and adverse pregnancy outcomes.
    Conclusions: This first bibliometric and visual analysis of periodontal disease and adverse pregnancy outcomes offers a concise overview of the field and suggests future research should focus on risk factors, high-risk populations, oral microbiota, mechanisms, interventions, and international collaboration.
    Keywords:  adverse pregnancy outcomes; bibliometric analysis; bidirectional; periodontal disease; risk factors
    DOI:  https://doi.org/10.3389/fmed.2025.1526406
  24. Acta Neurochir (Wien). 2025 Feb 07. 167(1): 38
    50 years of methylprednisolone application in spinal cord injury: a bibliometric analysis.
    Mi Zhou, Zhengyu Xu, Lei Feng, Hao Zhong, Hongjiang Yang, Guangzhi Ning, Shiqing Feng.
       PURPOSE: Methylprednisolone (MP) is a synthetic glucocorticoid known for its anti-inflammatory and immunosuppressive effects, yet its application in global spinal cord injury (SCI) research has not been thoroughly summarized. This study aims to assess the current status and trends of methylprednisolone research in SCI, providing insights for future scholarly work.
    METHODS: Articles on methylprednisolone in SCI published from 1975 to 2023 were retrieved from the Web of Science database. Metrics such as publication counts, H-index values, and data on countries, institutions, authors, and journals were analyzed. Co-citation, collaboration, and co-occurrence analyses of keywords were performed using CiteSpace.
    RESULTS: A total of 1,651 articles were identified, and publication numbers showed a consistent annual increase. The United States and Canada led in publication counts, H-index values, and citations, with the University of Toronto and the Veterans Health Administration being significant contributors. Bracken M.B. was the leading author. The most frequent keywords included 'trauma,' 'lipid peroxidation,' 'dose response,' 'ischemia,' and 'methylprednisolone.' A co-occurrence analysis classified 225 keywords into three clusters, highlighting key research areas in SCI.
    CONCLUSIONS: These findings offer valuable insights into authors, countries, institutions, keywords, and research hotspots in SCI over the past 50 years, guiding future research directions in this field.
    Keywords:  Bibliometrics; Lipid peroxidation; Methylprednisolone; Spinal cord injury; Trauma
    DOI:  https://doi.org/10.1007/s00701-025-06443-5
  25. Aesthetic Plast Surg. 2025 Feb 07.
    A Bibliometric Analysis of the Integration of mHealth, Telemedicine, and OpenAI in Aesthetic Plastic Surgery: Advancements, Trends, and Future Directions.
    Sa'ed H Zyoud.
      OpenAI, telemedicine, and mHealth have great potential in aesthetic plastic surgery, but their full potential has yet to be realized. Trends and research in this field have not been comprehensively evaluated using bibliometric tools. Therefore, this study aims to address these gaps by conducting a bibliometric analysis of the integration of mHealth, telemedicine, and OpenAI in aesthetic plastic surgery. Relevant publications were obtained through a comprehensive and validated search query. The SciVerse Scopus database was utilized, with the study spanning from January 1, 2015, to December 31, 2024. This study examined 776 publications on the integration of OpenAI, telemedicine, and mobile health (mHealth) in aesthetic plastic surgery. Of these, 547 (70.49%) were original research articles, 123 (15.85%) were review papers, and 56 (7.22%) were letters. Over the years, the number of Scopus-indexed publications grew steadily until 2018, after which there was a noticeable increase in publication volume (R2 = 0.9344; P < 0.001). The USA was the largest contributor, with 305 publications (39.3%), followed by the UK with 78 (10.05%), China with 65 (8.38%), and Italy with 53 (6.83%). Additionally, the theme of "implications of intelligent chatbots in clinical practise for plastic and reconstructive surgery" has become increasingly prominent in recent years, especially after 2022, highlighting a growing interest and emphasis in this area. This study provides a quantifiable overview of knowledge in the field, offering valuable evidence and guidance for future research, clinical applications, and educational efforts.Level of Evidence V This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
    Keywords:  Artificial intelligence; Bibliometric; OpenAI; Telemedicine; Visualization; mHealth
    DOI:  https://doi.org/10.1007/s00266-025-04730-1
  26. Phytomedicine. 2025 Jan 26. pii: S0944-7113(25)00049-2. [Epub ahead of print]138 156410
    Bibliometric analysis of literature on natural medicines against chronic kidney disease from 2001 to 2024.
    Xiaoqing Shi, Hongmei Yin, Xiaodan Shi.
       BACKGROUND: Chronic kidney disease (CKD) is a globally common and progressive disease. There has been few bibliometric study to analyze the status, hot spots, and trends in the field of natural medicines (NMs) against CKD.
    PURPOSE: To comprehensively understand the status, hot spots, and trends in the field of NMs against CKD.
    METHODS: The documents concerning NMs against CKD are extracted from the Web of Science Core Collection database (WOSCC). The literature analysis was conducted using VOSviewer 1.6.20 and CiteSpace 6.3.R1 software.
    RESULTS: In total, 641 publications were encompassed, which were produced by 3 548 authors and 823 organizations, 241 journals, and 56 countries/regions. The most productive author, institution, country, and journal were Li, Ping, Nanjing University of Chinese Medicine, China, and Journal of Ethnopharmacology, respectively. The first high-cited article was published in Medicinal Research Reviews with 457 citations authored by Huang and colleagues in 2007. Oxidative stress, anti-inflammatory, renal fibrosis, and gut microbiota were the emerging keywords. Rhubarb, Astragalus, Angelica, and Cordyceps, which contain anthraquinones, cordycepin, adenosine, or various polysaccharides, are promising NMs to prevent or treat CKD.
    CONCLUSION: Currently, the main hot spot is the elucidation of cellular and molecular mechanisms using novel technologies such as network pharmacology, molecular docking, and experimental validation. Future studies are needed to focus on the inherent molecular mechanisms and clinical applications. In addition, potential side effects of the bioactive compounds cannot be ignored.
    Keywords:  Bibliometric analysis; Diabetic nephrology; Molecular docking; Molecular mechanisms; Natural medicines; Network pharmacology
    DOI:  https://doi.org/10.1016/j.phymed.2025.156410
  27. Health Sci Rep. 2025 Feb;8(2): e70403
    A Decadal Bibliometric Analysis on the Therapeutic Strategies in Oral Lichen Planus.
    Kumar Chandan Srivastava, Ravinder S Saini, Galvin Sim Siang Lin, Artak Heboyan, Deepti Shrivastava.
       Background and Aims: Oral Lichen Planus (OLP) is a common chronic inflammatory autoimmune illness that mostly affects the oral mucosa but may also affect other mucous membrane. It has higher prevalence in female patients of fourth to sixth decade of life with reticular being the commonest clinical variant. Clinical assessment, patient history, biopsy findings, and immunofluorescence were used to diagnose OLP. This study aimed to assess research publication trends in therapeutic strategies in the treatment of OLP, examining publication growth, country and institution contributions, and collaborative networks.
    Methods: Using the Dimensions and Lens.org databases with Boolean operators combined the keywords a total of 40,046 peer-reviewed international publications were initially assessed. The article was selected from 2014 to December 2023. Through rigorous application of inclusion and exclusion criteria using an advanced search, a subset of 134 papers emerged to meet the high relevance standards. This subset, constituting a representative sample, was selected for in-depth bibliometric analysis.
    Results and Conclusion: The result shows a clear upward trend in the number of publications, with a notable increase in 2018. After 2018, there is decrease in the number of publications, but it has an upward trend, reaching a peak of 215 in 2022. Chaitanya Nallan CSK leads the list of authors with four publications and a respectable total citation count of 12. Cairo University is the leading institution in this data set, with the 8 number of publications and 11 citations. The analysis revealed that at the top of the list is the "Egyptian Dental Journal" from Egypt, with six publications, four citations, and a link strength of two. In the second position is "BMC Oral Health" from the United Kingdom, with five publications, one citation, and a link strength of three. This study offers valuable insights for future research, clinical practice, and policy decisions.
    Keywords:  Wickham striae; autoimmune disorder corticosteroid malignant; oral lichen planus; transformation
    DOI:  https://doi.org/10.1002/hsr2.70403
  28. Front Med (Lausanne). 2024 ;11 1488536
    A bibliometric analysis of exosomes in aging from 2007 to 2023.
    Zenghui Niu, Meiyu Cui, Yingkun Fu, Lingfeng Zhou, Jiali Wang, Yan Lei, Xinrong Fan, Qiang Wang, Jing Yang.
       Background: Aging is the primary factor contributing to the development of aging-related diseases. As research on exosomes continues to advance, its relationship with aging and aging-related diseases has become a hot topic This article analyzes the research hotspots of exosomes in aging and aging-related diseases, aiming to fill the gap in bibliometric research in this field and help researchers better understand the current status and future trends of both fundamental and clinical research in this field.
    Methods: The articles were retrieved and exported from WoSCC on December 18, 2023. The visual analysis of countries and regions, institutions, authors, references, and keywords in exosomes of aging was conducted using VOSviewer 1.6.18, CiteSpace 6.2.R7, and Bibliometrix.
    Results: The bibliometric analysis included 1628 articles. China and the United States emerged as the top two leading countries in this field. A total of 2,321 research institutions from 78 countries and regions were primarily led by China and the United States. Both Kapogiannis D and Goetzl E were active authors in this field. Thery C, Valadi H, and Raposo G were the important promoters in this field. Thery C proposed the method of differential centrifugation and density gradient centrifugation to extract exosomes. Valadi H discovered cells could send RNA-messages to each other by loading them into exosome-vesicles. The journal with the highest number of articles was International Journal of Molecular Sciences, while PLoS One was the most frequently cited journal. The keyword analysis revealed that future research on exosomes in aging will possibly focus on "inflammation, cellular senescence, angiogenesis, insulin resistance, and Alzheimer's disease."
    Conclusion: We identified the research trends of exosomes in the field of aging through this bibliometric analysis. The present study provides valuable new perspectives on the history and current status of exosomes in the field of aging and aging-related diseases, and also offering guidance for future research directions.
    Keywords:  aging; aging-related diseases; bibliometric; exosomes; senescence
    DOI:  https://doi.org/10.3389/fmed.2024.1488536
  29. Adv Ophthalmol Pract Res. 2025 Feb-Mar;5(1):5(1): 22-31
    Global incidence and trends of ocular cancer: A bibliometric analysis.
    Hang Xu, Alexander C Rokohl, Xiaojun Ju, Yongwei Guo, Xincen Hou, Wanlin Fan, Ludwig M Heindl.
       Background: Ocular cancer represents a significant threat to vision and life among various eye diseases. Conjunctival melanoma is regarded as one of the most feared and unpredictable ocular tumors. Considering the global differences in the occurrence of ocular melanoma across different races and regions, this study provides a thorough examination of the current state of research pertaining to the epidemiology of ocular and conjunctival cancers.
    Methods: This bibliometrics analysis used the Web of Science Core Collection (WoSCC) to collect data from publications on the epidemiology of ocular cancer, including relevant literature from 1951 to 2024. We examined indicators including t publication counts, citation rates, and data on contributing countries, institutions, and journals. Use VOSviewer and CiteSpace for network visualization and Microsoft Excel for data management. Our analysis reveals key trends in the epidemiology of ocular cancer across countries and identifies prominent keywords.
    Results: A total of 406 articles on ocular cancer were identified, with significant contributions from the United States, the United Kingdom, and Germany. Denmark also plays a crucial role, particularly in conjunctival cancer research. Carol L. Shields is a leading figure widely recognized for her influential citations in ocular cancer epidemiology. The top publication platforms include the British Journal of Ophthalmology, Ophthalmic Epidemiology, and Ophthalmology. Key terms in ocular cancer research focus on prevalence, survival, and epidemiology, while conjunctival cancer studies emphasize malignant melanoma, conjunctiva, and epidemiology. Through keyword co-occurrence and burst analysis, trending topics include prevalence, risk factors, uveal melanoma, choroidal melanoma, malignant melanoma, squamous cell carcinoma, and conjunctiva. For conjunctival cancer, key research areas expected to remain prominent are cell carcinoma, management, recurrence, ocular surface squamous neoplasia, and pathology.
    Conclusions: This analysis represents the first comprehensive bibliometric review mapping the trends and the knowledge structure in ocular cancer research, specifically from an epidemiological viewpoint. The results meticulously explore and encapsulate the research frontiers for scholars dedicated to the epidemiology of conjunctival cancer.
    Keywords:  Bibliometric analysis; Conjunctival cancer; Epidemiology; Incidence rate; Ocular cancer
    DOI:  https://doi.org/10.1016/j.aopr.2024.10.004
  30. Hum Vaccin Immunother. 2025 Dec;21(1): 2460272
    Research trends of neoadjuvant therapy for breast cancer: A bibliometric analysis.
    Laiping Xie, Yuhang Wang, Andi Wan, Lin Huang, Qing Wang, Wanyan Tang, Xiaowei Qi, Xiaofei Hu.
      The approach of neoadjuvant therapy for breast cancer, which involves administering systemic treatment prior to primary surgery, has undergone substantial advancements in recent decades. This strategy is intended to reduce tumor size, thereby enabling less invasive surgical procedures and enhancing patient outcomes. This study presents a comprehensive bibliometric analysis of research trends in neoadjuvant therapy for breast cancer from 2009 to 2024. Using data extracted from the Web of Science Core Collection, a total of 3,674 articles were analyzed to map the research landscape in this field. The analysis reveals a steady increase in publication output, peaking in 2022, with the United States and China identified as the leading contributors. Key institutions, such as the University of Texas System and MD Anderson Cancer Center, have been instrumental in advancing the research on neoadjuvant therapy. The study also highlights the contributions of influential authors like Sibylle Loibl and Gunter von Minckwitz, as well as major journals such as the Journal of Clinical Oncology. Emerging research topics, including immunotherapy, liquid biopsy, and artificial intelligence, are gaining prominence and represent potential future directions for clinical applications. This bibliometric analysis provides critical insights into global research trends, key contributors, and future developments in the field of neoadjuvant therapy for breast cancer, offering a foundation for future research and clinical practice advancements.
    Keywords:  Neoadjuvant therapy; artificial intelligence; bibliometric analysis; breast cancer; immunotherapy; pathological complete response; research trends
    DOI:  https://doi.org/10.1080/21645515.2025.2460272
  31. Ren Fail. 2025 Dec;47(1): 2458754
    Artificial intelligence in kidney transplantation: a 30-year bibliometric analysis of research trends, innovations, and future directions.
    Ying Jia He, Pin Lin Liu, Tao Wei, Tao Liu, Yi Fei Li, Jing Yang, Wen Xing Fan.
      Kidney transplantation is the definitive treatment for end-stage renal disease (ESRD), yet challenges persist in optimizing donor-recipient matching, postoperative care, and immunosuppressive strategies. This study employs bibliometric analysis to evaluate 890 publications from 1993 to 2023, using tools such as CiteSpace and VOSviewer, to identify global trends, research hotspots, and future opportunities in applying artificial intelligence (AI) to kidney transplantation. Our analysis highlights the United States as the leading contributor to the field, with significant outputs from Mayo Clinic and leading authors like Cheungpasitporn W. Key research themes include AI-driven advancements in donor matching, deep learning for post-transplant monitoring, and machine learning algorithms for personalized immunosuppressive therapies. The findings underscore a rapid expansion in AI applications since 2017, with emerging trends in personalized medicine, multimodal data fusion, and telehealth. This bibliometric review provides a comprehensive resource for researchers and clinicians, offering insights into the evolution of AI in kidney transplantation and guiding future studies toward transformative applications in transplantation science.
    Keywords:  Bibliometric analysis; artificial intelligence; kidney transplantation; research hotspots; research trends
    DOI:  https://doi.org/10.1080/0886022X.2025.2458754
  32. Hereditas. 2025 Feb 01. 162(1): 14
    Association between chronic obstructive pulmonary disease and osteoporosis: Mendelian randomization combined with bibliometric analysis.
    Fangjun Yang, Huaming Wang, Miaomiao Liu, Shengtai Pei, Xiaoming Qiu.
       BACKGROUND: Previous observational studies have reported an association between chronic obstructive pulmonary disease (COPD) and osteoporosis (OP). The aim of this study is to investigate the causal relationship between COPD and OP by two-sample Mendelian randomization (MR) analysis. The current status of cross-sectional research between COPD and OP in the past decade was explored through bibliometrics.
    METHODS: Single nucleotide polymorphisms (SNPs) that have been found to be strongly associated with COPD were used as instrumental variables (IVs) in MR Analysis. The primary outcome of the study was BMD measurement at five specific anatomical sites, namely the whole body, femoral neck, lumbar spine, forearm, and heel. These BMD measurements were derived primarily from a genome-wide association study (GWAS) and summary statistics from the International Genetic Factors Consortium for Osteoporosis (GEFOS). The main analysis method was inverse variance weighting (IVW). Multiple sensitivity analyses were performed to assess the robustness and reliability of the current MR Results. Further confirmatory MR Analysis between COPD and OP was applied. In bibliometrics. Publications were extracted from the Web of Science core collection publications related to osteoporosis and sarcopenia published between January 2014 and October 2024; Bibliometrics and visualization were performed by Microsoft Office Excel, Citespace, and R (Bibliometrix).
    RESULTS: The MR Findings suggest that there is no causal relationship between COPD and BMD at five specific anatomical sites. The results of the primary IVW MR Analysis were generally supported by our sensitivity MR Analysis. We performed MR Analysis for the validation of COPD and OP (IVW OR: 1.019; 95%CI: 0.898-1.564; p = 0.768) also did not support a causal relationship between COPD and BMD. A total of 471 articles written by 1119 organizations from 42 countries/regions by 3331 authors and published in 238 journals were identified in the bibliometric analysis. China is the leading country in terms of the number of publications. China Medical University contributed the most publications. The International Journal of Chronic Obstructive Pulmonary Disease has the highest publication in this field.
    CONCLUSIONS: In conclusion, This MR Study found no causal relationship between COPD and OP, suggesting that the observed associations may be due to common genetic effects or environmental confounders. The global research trends in this field in the past decade were summarized through bibliometric analysis, and care became the focus of future research on the relationship between copd and OP.
    Keywords:  Bibliometric analysis; Chronic obstructive pulmonary disease; CiteSpace; Mendelian randomization; Osteoporosis; Relationship
    DOI:  https://doi.org/10.1186/s41065-025-00373-z
  33. Health Sci Rep. 2025 Feb;8(2): e70409
    Web of Science-Based Visualization of Metabolic Dysfunction-Associated Fatty Liver Disease in Pediatric and Adolescent Populations: A Bibliometric Study.
    Liangyu Hu, Huarong Du, QianQian Zhou, Chunlei Liu, Tiansong Zhang, Min Yuan.
       Background and Aims: The prevalence of metabolism-associated fatty liver disease (MAFLD) in children is on the rise. This study employs visualization and analysis to evaluate the research implications, current advancements, and emerging trends in pediatric MAFLD, with the aim of elucidating its pathogenesis and informing the development of clinical treatment strategies.
    Methods: Using visualization software, we conducted a visual analysis and mapping of the journal distribution, leading institutions, prominent authors, annual publication trends, and keyword frequencies among the 1179 scholarly articles retrieved from the Web of Science Core Collection for this study.
    Results: The overall publication volume demonstrated an upward trend, with a total of 200 journals, contributions from 63 countries, 882 research institutions, and 5605 authors involved, including 84 who were identified as core authors. The main research team is led by Nobili, Valerio. The main research institutions are concentrated in Italy, the United States, and China. A total of 473 keywords were included, and the keywords with high frequency and medium centricity are insulin resistance, metabolic syndrome, children, steatohepatitis, adolescents, hepatic steatosis, nash, obesity, diagnosis, and fibrosis, which resulted in six keyword clusters.
    Conclusion: MAFLD represents a significant public health concern. Research on children and adolescents with MAFLD continues to attract high interest. Noninvasive diagnostic methods, pathogenesis (intestinal microbiota research), disease prediction (gene research) are current research hotspots.
    Keywords:  MAFLD; adolescents; children; visual analysis
    DOI:  https://doi.org/10.1002/hsr2.70409
  34. Heliyon. 2025 Jan 30. 11(2): e42102
    Bibliometric study of plastics microfluidic chip from 1994 to 2022: A review.
    Rhesa Muhammad Faisal, Olusola Olaitan Ayeleru, Helen Uchenna Modekwe, Ishmael Matala Ramatsa.
      Microfluidic tools are widely used in research and manufacturing to manipulate fluids in micrometer channels. These tools are useful for detecting cell cultures, food pathogens, biomedical, energy, and disease. The affordability, versatility, biocompatibility, strength, and transparency of thermoplastics have contributed to its widespread use in the commercialization of microfluidic chips. A bibliometric study of plastic microfluidic chips was conducted using publications from the Scopus database between 1994 and 2022. The study analysed publications based on countries, journals, authorship, and keywords, while VOSviewer software was used for the visualization. Results showed that the United States and China were the most dominant article producers, accounting for almost 50 % of publications. Lab On a Chip was the most active journal, with 22.84 % of its publications involved in microfluidic chips. The network of keywords was coupled and concluded that Polydimethylsiloxane (PDMS), Polymethyl methacrylate (PMMA), Polystyrene (PS), and Cyclic olefin copolymer (COC) benefitted the researchers of microfluidic chips owing to their biocompatibility, durability, optically transparent, and inexpensiveness. By identifying global trends, key materials, and leading contributors in plastic microfluidic chip research, this study offers valuable insights into the most influential countries, leading journals, and primary materials. These insights are instrumental in guiding researchers, manufacturers, and academics in selecting future research directions and better material choices, particularly in the fields of biomedical diagnostics, food safety, and energy solutions.
    Keywords:  Authorship analysis; Bibliometric; Content analysis; Microfluidic chip; Thermoplastics
    DOI:  https://doi.org/10.1016/j.heliyon.2025.e42102
  35. Clin Nutr. 2025 Jan 21. pii: S0261-5614(25)00022-6. [Epub ahead of print]46 72-79
    Determinants of journal impact factors in 'Nutrition and Dietetics'.
    Dileep N Lobo, Keith R Neal.
       BACKGROUND AND AIM: The aim of this cross-sectional study was to analyse determinants of the 2023 impact factors (IFs) of journals within the field of 'Nutrition and Dietetics'.
    METHODS: The Clarivate™ Journal Citation Reports™ website (https://jcr.clarivate.com/jcr/home) was searched on 9 January 2025 for journals with a 2023 IF (published in June 2024) ≥ 6.0 in the field of 'Nutrition and Dietetics'. Analysis was performed using GraphPad Prism software.
    RESULTS: There were there were 84,040 citations in 2023 to 10,719 works published in 2021 and 2022 in the 12 journals with an IF ≥ 6.0. Median numbers of citations per output were lower than mean citations in all journals. This difference ranged from 0.55 to 3.97. Most outputs (47.5%-79.1 %) had 1-10 citations. The 1538 open access outputs were cited less frequently [mean (95 % CI) 6.98 (6.55-7.40)] than the 9181 subscription outputs [7.99 (7.81-8.16), P < 0.0001]. The 2063 reviews were cited more frequently [8.94 (8.45-9.43)] than the 8656 original articles [7.58 (7.42-7.74), P < 0.0001]. When the highest cited outputs from each journal were excluded, the fall in IFs ranged from 0 to 2.4. The was also the case when the two highest cited outputs were excluded (fall ranged from 0 to 2.7).
    CONCLUSION: This comprehensive analysis of journal IFs has shown that although review articles increase IFs of journals, open access outputs do not. IFs can be distorted by 1 or 2 highly cited outputs and may not reflect the impact of the majority of outputs.
    Keywords:  Bibliometrics; Clarivate™; Determinants; Journal Citation Reports™; Journal impact factor; Nutrition and Dietetics
    DOI:  https://doi.org/10.1016/j.clnu.2025.01.021
  36. Front Pharmacol. 2025 ;16 1533984
    Global bibliometric analysis of traditional Chinese medicine regulating gut microbiota in the treatment of diabetes from 2004 to 2024.
    Jieling Liang, Xiaojuan Lin, Xin Liao, Xi Chen, Ying Zhou, Lin Zhang, Yunyun Qin, Haoru Meng, Zhongwen Feng.
       Objectives: The therapeutic efficacy of Traditional Chinese Medicine (TCM) in modulating gut microbiota for diabetes treatment has garnered increasing scholarly attention. This study aims to meticulously examine current research trajectories and focal areas from 2004 to 2024, providing a foundational framework for future inquiries.
    Methods: A comprehensive search of documents published between 2004 and 2024 was conducted using the Web of Science database. The resulting data were analyzed and visualized using R software, VOSviewer, and CiteSpace.
    Results: The study included a total of 751 documents. From 2004 to 2022, the number of annual publications showed a continuous upward trend (2004: n = 1 to 2022: n = 159), and the number of publications in 2023 (n = 141) decreased slightly from the previous year. China emerged as the leading country in terms of article publications (n = 430). Additionally, the United States played a prominent role in international research collaborations. Frontiers in Pharmacology (n = 31) was the most frequently published journal, while Nature (n = 1,147) achieved the highest citation count. Key identified keywords included obesity, insulin resistance, inflammation, and oxidative stress.
    Conclusion: Three key research focuses in this domain include: the therapeutic effects of active constituents in TCM on diabetes via gut microbiota modulation, the underlying mechanisms through which TCM influences gut microbiota in diabetes management, and the targeted regulation of specific gut bacterial populations by TCM in the treatment of diabetes.
    Keywords:  active constituents; diabetes; gut microbiota; mechanism; traditional Chinese medicine
    DOI:  https://doi.org/10.3389/fphar.2025.1533984
  37. Eur Arch Otorhinolaryngol. 2025 Feb 06.
    Advancements and future directions in chronic rhinosinusitis: understanding inflammatory mechanisms (2000-2023).
    Sheng Long, Huan Wang, Wanpeng Li, Li Hu, Huapeng Yu, Zhuofu Liu, Kun Du, Xicai Sun, Dehui Wang, Han Li.
       OBJECTIVE: To characterize research on inflammation in CRS over the past 23 years, and analyze trends in hotspots, and collaboration networks.
    METHODS: We conducted a methodological, objective, and extensive analysis of inflammation in CRS to track research trends and hotspots. Original research literature published between 2000 and 2023 was obtained from The Web of Science Core Collection (WoSCC) database. Data on country/region, institution, author, journal, keywords, and references were extracted using VOSviewer and CiteSpace for analysis.
    RESULTS: The number of publications on inflammation in CRS has significantly increased over the past 23 years. The United States has been the most prolific contributor in terms of publications and collaborations. The top 10 high-frequency keywords were "chronic rhinosinusitis," "nasal polyps," "asthma," "inflammation," "sinusitis," "rhinosinusitis," "eosinophils," "nasal polyposis," "chronic rhinosinusitis with nasal polyps," and "allergic rhinitis." The timeline view revealed changes in keywords over time, with endotype and biologics emerging as recent hotspots.
    CONCLUSIONS: Substantial improvement has been made in the study of inflammation in CRS. The United States leads with the most published articles, productive institutions, and influential journals. Strengthening collaborations between institutions and countries is recommended. The current focus is primarily on immunotherapy, and inflammation in CRS is likely to continue being a prominent topic.
    Keywords:  Bibliometrics analysis; Chronic rhinosinusitis; CiteSpace; Inflammation; VOSviewer
    DOI:  https://doi.org/10.1007/s00405-025-09245-8
  38. F1000Res. 2025 ;14 122
    Artificial Intelligence and Finance: A bibliometric review on the Trends, Influences, and Research Directions.
    Prasenjit Roy, Biswajit Ghose, Premendra Kumar Singh, Pankaj Kumar Tyagi, Asokan Vasudevan.
       Background: This bibliometric study examines the intersection of artificial intelligence (AI) and finance, providing a comprehensive analysis of its evolution, central themes, and avenues for further exploration. The study aims to uncover the theoretical foundations, methodological approaches, and practical implications of AI in financial contexts.
    Methods: The research employs bibliometric techniques, using 607 Web of Science (WoS) indexed papers. The Theory-Context-Characteristics-Methodology (TCCM) framework guides the analysis, focusing on thematic mapping to explore key topics. Core areas such as risk management, market efficiency, and innovation are analyzed, alongside emerging themes like ethical AI, finance applications, and factors influencing AI-driven financial decision-making.
    Results: The findings reveal critical gaps in interdisciplinary methods, ethical considerations, and methodological advancements necessary to develop robust and transparent AI systems. Thematic mapping highlights the increasing importance of ethical AI practices and the influence of AI on financial decision-making processes. Emerging research areas emphasize the need for innovative frameworks and solutions to address current challenges.
    Conclusions: This study provides valuable insights for academics, industry practitioners, and policymakers to harness transformative potential of AI in finance. This research offers a foundation for future studies and practical applications by addressing key gaps and promoting interdisciplinary and ethical approaches in a rapidly evolving field.
    Keywords:  Artificial Intelligence; Bibliometric Analysis; Finance; TCCM; Thematic Mapping
    DOI:  https://doi.org/10.12688/f1000research.160959.1
  39. Heliyon. 2025 Jan 30. 11(2): e41513
    Publication trends and green cosmetics buying behaviour: A comprehensive bibliometric analysis.
    Mamta, Gyan Prakash.
      Green cosmetics have gained increasing attention in the research community. This study conducts a comprehensive review of 164 publications from the past decade (2011-2022) to provide an up-to-date analysis of consumer purchasing behaviour regarding green cosmetics. It examines consumers' purchasing decisions, performance, and intellectual frameworks and identifies the field's most influential journals, prolific authors, institutions, and nations. The study also sheds light on five critical themes related to green cosmetics buying behaviour: environmental concern, green marketing, sustainable consumption, green cosmetics, and green consumerism. By offering insights into these aspects, this research contributes to the knowledge base for future studies, aids policymakers, and assists marketing managers in promoting green cosmetics buying behaviour.
    Keywords:  Bibliometric analysis; Green buying behaviour; Green consumerism; Green cosmetics; Green products; Organic cosmetics; Sustainable cosmetics; Systematic literature review
    DOI:  https://doi.org/10.1016/j.heliyon.2024.e41513
  40. Osteoarthritis Cartilage. 2025 Jan 31. pii: S1063-4584(25)00021-4. [Epub ahead of print]
    Foot osteoarthritis research: A bibliometric analysis.
    International Foot and Ankle Osteoarthritis Consortium
       OBJECTIVE: To conduct a bibliographic analysis of English language, non-surgical research pertaining to foot osteoarthritis (OA).
    DESIGN: A Scopus® database search was conducted to identify all non-surgical foot OA articles published in English up until December 2023. Bibliometric analysis was performed using an open-source tool based on the R language. Citations, journals, authors, institutions, and countries were described. Publications were manually categorised according to research type and funding source.
    RESULTS: The search strategy yielded 121 eligible articles, which received a total of 4531 citations and were published by 372 authors in 55 journals. The highest publication output occurred in the past decade. The most frequent journals were Arthritis Care & Research, Osteoarthritis and Cartilage, Journal of the American Podiatric Medical Association, Annals of the Rheumatic Diseases, Foot & Ankle International and Journal of Foot and Ankle Research. The most published institutions were Keele University, La Trobe University, the University of Leeds, the University of Melbourne and the University of North Carolina. Of the 106 articles that could be classified, most were focused on aetiology (n=52, 49%), followed by evaluation of treatments and therapeutic interventions (n=28, 26%), detection, screening and diagnosis (n=17, 16%), health and social care services research (n=6, 6%) and underpinning research (3, 3%). Fifty-one articles (42%) reported no research funding.
    CONCLUSION: Foot OA research has increased significantly in the past decade. There is a need, however, to improve our understanding of the condition and to address the relatively small number of clinical trials that have been conducted.
    Keywords:  Bibliometrics; Foot; Osteoarthritis
    DOI:  https://doi.org/10.1016/j.joca.2024.12.009
  41. Ecol Evol. 2025 Feb;15(2): e70938
    Research Status and Development Trend of Greenhouse Gas in Wetlands: A Bibliometric Visualization Analysis.
    Gege Zhu, Yan Wang, Anshu Huang, Yingying Qin.
      With the intensification of global warming, wetland greenhouse gas (GHG) emissions have attracted worldwide attention. However, the scientific understanding of wetland GHGs is still limited. To gain a comprehensive and systematic understanding of the current research status and development trends in wetland GHGs. We selected 1627 papers related to wetland GHG research from the Web of Science Core Collection database and used the bibliometric visualization analysis method to reveal the annual publication, main core research forces, research hotspots, and trends in this field. The results showed that the research in this field shows a steady upward trend. United States research institutions and scholars play a key role in this field. The research on "climate change" based on three major wetland GHGs (carbon dioxide (CO2), methane (CH4), and nitrous oxide (N2O)) has been continuously gaining popularity. In recent years, "water" has become an emerging core topic. More and more studies have focused on enhancing wetland pollutant treatment capacity, improving wetland ecosystem productivity, maintaining water level stability, strengthening blue carbon sink function, exploring remote sensing applications in wetlands, and promoting wetland restoration to reduce GHG emissions. Furthermore, we discussed the influencing factors of the emission of CO2, CH4, and N2O in wetlands and summarized the potential methods to reduce GHG emissions. The findings provide scientific guidance and reference on wetland sustainable development and GHG emission reduction.
    Keywords:  CiteSpace; bibliometrics; emission reduction strategies; greenhouse gas; web of science; wetlands
    DOI:  https://doi.org/10.1002/ece3.70938
  42. J Shoulder Elbow Surg. 2025 Jan 29. pii: S1058-2746(25)00095-3. [Epub ahead of print]
    Publication Trends in The Journal of Shoulder and Elbow Surgery.
    Molly M Piper, Bhargavi Maheshwer, Casey Kuka, Lucas R Haase, Robert J Gillespie, Raymond E Chen.
       BACKGROUND: As the field of orthopedic surgery advances, the quality of research articles and characteristics of authors of these publications continue to change. Various orthopedic journals report that there has been an increased number of authors per publication over the years. However, there have not been any reported changes in publication trends in upper extremity orthopedic journals over the past decade. Thus, the purpose of this study is to evaluate trends in characteristics of articles published in the Journal of Shoulder and Elbow Surgery (JSES) from 2012 to 2022, including type of study, level of evidence, country of publication, and author information.
    METHODS: Articles published in JSES between 2012 and 2022 were retrieved from the JSES Archives. Title, level of evidence, description of the study as delineated in the abstract, first author degree, number of authors, and country of publication were recorded for each published article.
    RESULTS: A total of 3577 articles were published in JSES from 2012 to 2022. The average number of authors per article was 5.77 ± 2.6 with a significantly increasing trend over the study period. There was also a significant increase in non-MD or equivalent first authorship. The proportion of clinical studies with original data published per year significantly decreased while studies with non-original data including systematic reviews, meta-analyses, and narrative reviews significantly increased over the study period.
    CONCLUSION: There have been various publication trends in JSES over the last decade. These trends are important to acknowledge when evaluating the quality of recent publications.
    Keywords:  basic science; clinical studies; level of evidence; meta-analysis; publication trends; systematic review
    DOI:  https://doi.org/10.1016/j.jse.2024.12.022
  43. Curr Alzheimer Res. 2025 Feb 03.
    Visualization Analysis of Tau Protein in the Brain of Alzheimer's Disease: A Scoping Literature Review.
    Dan-Qi Zhang, Xu Yang, Han-Bin Niu, Xu-Chen Sun, Dan-Na Cao, Ang Li, Jin-Huan Yue, Xiao-Ling Li, Qin-Hong Zhang.
       INTRODUCTION: This study analyzed the current status, hotspots, and development trends of tau protein research in Alzheimer's disease (AD) and to provide a reference for future research in this field. CiteSpace software was used to scientifically measure and visualize the relevant articles in the field of tau protein in AD brain from the Web of Science Core Collection database from 1991 to 2022.
    METHODS: A total of 568 articles were included, with an exponential growth in the number of articles published from 1991 to 2022, with an average of 17.8 articles per year. The United States is the most productive country in this field, accounting for 46.83% of the total literature. The New York State Institute for Basic Research is the most productive organization, followed by MRC Laboratory Molecular Biology in the UK. The most influential are Kings College London, University of California, San Francisco, and others. Iqbal K is the most productive author.
    RESULTS: The most productive journal is the Journal of Biological Chemistry, and the journal with the highest impact factor is Acta Neuropathologica. The journal with the highest cumulative impact factor is Nature. The research hotspots mainly focus on the formation and degradation mechanisms of tau protein paired helical filaments and abnormal phosphorylation, AD neurofibrillary tangles and degenerative changes, and model research, mainly involving tau protein abnormal phosphorylation, phosphorylation sites, dephosphorylation, aggregate helical filaments, neurofibrillary tangles mouse models.
    CONCLUSION: The research frontier trends mainly focus on the study of pathological changes in tau protein, intervention mechanisms, and the development and practice of clinical therapeutic drugs.
    Keywords:  Alzheimer’s disease; CiteSpace; frontier trends; hotspots; phosphorylation sites; tangles mouse.; tau protein
    DOI:  https://doi.org/10.2174/0115672050351995241223065923
  44. Front Microbiol. 2024 ;15 1516584
    Global insights into MRSA bacteremia: a bibliometric analysis and future outlook.
    Jia-Yi Lin, Jia-Kai Lai, Jian-Yi Chen, Jia-Yu Cai, Zhan-Dong Yang, Liu-Qingqing Yang, Ze-Tao Zheng, Xu-Guang Guo.
       Background: Methicillin-resistant Staphylococcus aureus (MRSA) bloodstream infections (BSIs) pose a significant challenge to global public health, characterized by high morbidity and mortality rates, particularly in immunocompromised patients. Despite extensive research, the rapid development of MRSA antibiotic resistance has outpaced current treatment methods, increasing the difficulty of treatment. Therefore, reviewing research on MRSA BSIs is crucial.
    Methods: This study conducted a bibliometric analysis, retrieving and analyzing 1,621 publications related to MRSA BSIs from 2006 to 2024. The literature was sourced from the Web of Science Core Collection (WoSCC), and data visualization and trend analysis were performed using VOSviewer, CiteSpace, and Bibliometrix software packages.
    Results: The bibliometric analysis showed that research on MRSA BSIs was primarily concentrated in the United States, China, and Japan. The United States leads in research output and influence, with significant contributions from institutions such as the University of California system and the University of Texas system. The journal with the most publications is Antimicrobial Agents and Chemotherapy, while the most cited global publication is Vincent JL's article "Sepsis in European Intensive Care Units: Results of the SOAP Study" published in Critical Care Medicine in 2006. Cosgrove SE's article "Comparison of Mortality Associated with Methicillin-Resistant and Methicillin-Susceptible Staphylococcus aureus Bacteremia: A Meta-analysis" had the most co-citations. Key trends in the research include MRSA's antibiotic resistance mechanisms, the application of new diagnostic technologies, and the impact of COVID-19 on MRSA studies. Additionally, artificial intelligence (AI) and machine learning are increasingly applied in MRSA diagnosis and treatment, and phage therapy and vaccine development have become future research hotspots.
    Conclusion: Methicillin-resistant Staphylococcus aureus BSIs remain a major global public health challenge, especially with the increasing severity of antibiotic resistance. Although progress has been made in new treatments and diagnostic technologies, further validation is required. Future research will rely on integrating genomics, AI, and machine learning to drive personalized treatment. Strengthening global cooperation, particularly in resource-limited countries, will be key to effectively addressing MRSA BSIs.
    Keywords:  MRSA; antibiotic resistance; artificial intelligence in diagnosis; bloodstream infection; personalized medicine
    DOI:  https://doi.org/10.3389/fmicb.2024.1516584
  45. J Clin Epidemiol. 2025 Jan 30. pii: S0895-4356(25)00038-1. [Epub ahead of print] 111705
    Massive covidization and subsequent decovidization of the scientific literature involved 2 million authors.
    John P A Ioannidis, Thomas A Collins, Eran Bendavid, Jeroen Baas.
       OBJECTIVE: We aimed to examine the growth trajectory and impact of COVID-19-related papers in the scientific literature and how the scientific workforce engaged in this work.
    STUDY DESIGN AND SETTING: We used Scopus data to August 1, 2024 and a search string for COVID-19-related publications. Authors of COVID-19 work were mapped against databases of top-cited authors.
    RESULTS: Scopus indexed 718,660 COVID-19-related publications. As proportion of all indexed scientific publications, COVID-19-related publications peaked in September 2021 (4.7%) remained at 4.3-4.6% for another year and then gradually declined, but was still 1.9% in July 2024. COVID-19-related publications included 1,978,612 unique authors: 1,127,215 authors had ≥5 full papers in their career and 53,418 authors were in the top-2% of their scientific subfield. Authors with >10%, >30% and >50% of their total career citations be to COVID-19-related publications were 376,942, 201,702, and 125,523, respectively. As of August 1, 2024, 65 of the top-100 most-cited papers published in 2020 were COVID-19-related, declining to 24/100, 19/100, 7/100, and 5/100 for the most-cited papers published in 2021, 2022, 2023, and 2024, respectively. Across 174 scientific subfields, 132 had ≥10% of their active influential (top-2% by composite citation indicator) authors publish something on COVID-19 during 2020-2024. Among the 300 authors with highest composite citation indicator specifically for their COVID-19-related publications, 41 were editors or journalists/columnists.
    CONCLUSIONS: COVID-19 massively engaged the scientific workforce in unprecedented ways. As the pandemic ended, there has been a sharp decline in the overall volume and high impact of newly published COVID-19-related publications.
    Keywords:  COVID-19; authorship; bibliometrics; citations
    DOI:  https://doi.org/10.1016/j.jclinepi.2025.111705
  46. OTA Int. 2025 Mar;8(1): e361
    The Impact of National Orthopaedic Fracture Registries: A Systematic Review.
    Nicolas Jozefowski, Carlo Eikani, Nithya Lingampalli, Patrick Lawler, Athena Barrett, Aaron Hoyt, Andrew Pickles, Elizabeth Huggins, Julie Agel, Rachel Seymour, Mai Nguyen, Meir Marmor, Ashley E Levack.
       Purpose: Large-scale registry data efforts are common in orthopaedic surgery; however, there is wide variation between registries and little known about registry impact. The purpose of this study was to assess the publication or "scholarly" impact of current national trauma/fracture registries.
    Methods: A search was executed to identify potential national and international trauma/fracture registries and create a comprehensive list of registries. Thirty-four relevant national registries were identified. Searches were executed to identify any published articles published by or affiliated with the selected registries. Over 13,000 abstracts were screened by at least 2 reviewers. The full text of 650 articles were screened by at least 2 reviewers, and data were extracted from 383 articles. Citations were excluded if they were reviews and meta-analyses; referencing non-trauma-specific, insurance, institutional, or state-wide databases; describing facial, spine, or rib trauma; reporting nonregistry data; and did not report on fracture patients. Data were collected at the article level and registry level.
    Results: The median number of articles per registry was 3.5 (range: 1-66) with a median impact factor of 3.2 (range per registry: 1.4-11.0). The National Hip Fracture Database (United Kingdom) had the highest publication rate per year of any registry (3.9). Twenty-four percent of registries had a publication rate of greater than 1 article per year, whereas only 8.8% had a publication rate over 2 per year. Only 8 registries had 10 or more publications in total. The National Trauma Data Bank (United States) had the highest number of fracture-specific publications overall (66) and an average citation rate of 29 per publication. The National Hip Fracture Database had the second highest number of article (62) with an average citation per article of 23.6.
    Conclusion: With the exception of a few registries, most national trauma/fracture registries have low yearly publication and citation rates. Researchers must consider the utility of resources needed to sustain registry efforts in the context of the impact of registry data. Future studies will seek to identify salient features of the highest impact registries.
    Keywords:  fracture registry; trauma registry
    DOI:  https://doi.org/10.1097/OI9.0000000000000361
  47. J Med Internet Res. 2025 Feb 03. 27 e60616
    Publication Counts in Context: Normalization Using Query and Reference Terms in PubMed.
    Julian Varghese, Lucas Bickmann, Timo Strünker, Nina Neuhaus, Frank Tüttelmann, Sarah Sandmann.
      This article discusses the extensive use of publication counts as indicators of trends in the scientific activities of individual researchers, research groups, and entire disciplines. However, with the growing number of articles in general, these counts might produce false impressions among scientists. We propose a straightforward yet effective normalization method, which enables further context of publication counts by using a query and a reference term. Additionally, an open access implementation is readily available on the PubMed Normalization website.
    Keywords:  H-index; citation; normalization; publication; publication database; scholarly; science communication; scientometrics; trend
    DOI:  https://doi.org/10.2196/60616
  48. Front Toxicol. 2024 ;6 1533722
    Investigating the research landscape of chlorinated paraffins over the past ten decades.
    Chinemerem Ruth Ohoro, Chijioke Olisah, Victor Wepener.
      Chlorinated paraffins (CPs) are classified as emerging persistent organic pollutants (POPs). Due to their associated environmental and health impacts, these groups of chemicals have been a subject of interest among researchers in the past decades. Here we used a scientometric approach to understand the research landscape of CPs using literature published in the Web of Science and Scopus database. RStudio and VOSviewer programs were employed as scientometric tools to analyze the publication trends in global CP-related research from 1916 to 2024. A total of 1,452 articles were published over this period, with a publication/author and co-author/publication ratio of 0.43 and 5.49, respectively. China ranked first in publication output (n = 556, 43.3%), and the highest total citations (n = 12,007), followed by Sweden (n = 90), Canada (n = 77), and Germany (n = 75). Publications from developing countries were limited, with most contributions from Africa originating from Egypt (n = 7), South Africa (n = 5), and Nigeria (n = 3), primarily through international collaborations. The average annual growth rate of 4.3% suggests a significant future article output. This scientometric analysis allowed us to infer global trends in CPs, identify tendencies and gaps, and contribute to future research. Despite having similar toxicity to short-chain chlorinated paraffin (SCCP), long-chain chlorinated paraffin (LCCP) has received less attention. Therefore, future research should prioritize studying LCCP bioaccumulation and toxicity in diverse food webs, focusing on aquatic species vulnerable to CPs and effective toxicological models. Additionally, collaborative research with developing countries should be encouraged to enhance meeting the Stockholm Convention's demand.
    Keywords:  chlorinated paraffin; long-chain chlorinated paraffins; medium-chain chlorinated paraffin; persistent organic pollutants (POPs); scientometric analysis; short-chain chlorinated paraffin
    DOI:  https://doi.org/10.3389/ftox.2024.1533722
  49. Cancer Prev Res (Phila). 2025 Feb 03. 18(2): 55
    Editors' Selections from Relevant Scientific Publications.
      
    DOI:  https://doi.org/10.1158/1940-6207.CAPR-18-2-HFL
  50. Can J Ophthalmol. 2025 Jan 29. pii: S0008-4182(25)00005-5. [Epub ahead of print]
    Educational background, professional experience, and research productivity of Canada's academic ophthalmology leadership.
    Waleed K Alsarhani, Ahmed Abdelaal, Cynthia L Larche, Amandeep S Rai, Peter J Kertes.
       OBJECTIVE: The aim of the study was to assess the educational background, professional experience, and research productivity of the Canada's academic ophthalmology leadership.
    METHODS: This cross-sectional study focused on leaders from ophthalmology departments at 15 Canadian universities, as well as the Canadian Journal of Ophthalmology (CJO) editorial board and the Canadian Ophthalmological Society (COS) board of directors.
    RESULTS: Ninety-one academic leaders were identified, which included 15 chairs, 9 vice chairs, 17 hospital chiefs, and 15 program directors. Additionally, the 10 members of the COS board of directors and the 31 members of the editorial board of the CJO were included. The duration of professional experience was the longest for hospital chiefs (26.63 ± 7.08 years) followed by chairs (23.86 ± 6.11 years) (p < 0.001). Chairs had the largest mean number of publications (87.13 ± 73.17), followed by vice chairs (70.89 ± 78.29) (p = 0.012). The most common residency programs attended by position holders were offered by the University of Toronto, followed by McGill University. Forty-three academic ophthalmology leaders graduated from U.S. fellowship training programs (48.3%). CJO editors were most likely to have a professor appointment (p = 0.002), fellowship training (p = 0.042), U.S. fellowship training (p = 0.007), a larger number of publications (p = 0.006), and a greater h-index (p = 0.001).
    CONCLUSION: Chairs followed by vice chairs demonstrated the highest mean number of publications and h-index. More than half of the academic leaders had fellowship training either in the U.S. or Toronto. Prospective ophthalmologists interested in academic leadership may leverage these data to strategically guide their professional careers.
    DOI:  https://doi.org/10.1016/j.jcjo.2025.01.007
  51. Int J Med Sci. 2025 ;22(3): 508-527
    Deciphering Epigenetic and Post-Translational Modifications in Ferroptosis: A Scientometric and Visualization Study.
    Siyang Cao, Yihao Wei, Yaohang Yue, Deli Wang, Ao Xiong, Hui Zeng.
      Background: Recent research emphasizes the significant regulatory functions of epigenetic alterations and post-translational modifications (PTMs) in the ferroptosis process. Despite the existing volume of literature, there is a remarkable shortage of comprehensive analyses that systematically trace the evolution of research, map key investigative routes, evaluate the current situation of the field, determine central themes, and predict future directions. This study intends to offer a comprehensive summary of the progress achieved during the past 12 years in comprehending how epigenetic modifications and PTMs regulate ferroptosis. Methods: The dataset originated from the Web of Science, covering the period from January 1, 2012, to May 21, 2024. By employing advanced analytical tools, we carried out an extensive scientometric assessment in combination with detailed visual data analysis. Results: The results emphasize the crucial role of China, which contributes 69.59% of the global research output, thereby demonstrating its significant influence on the research trajectory in this domain. Remarkable productivity is manifested at institutions such as Central South University, Shanghai Jiao Tong University, and Zhejiang University. Liu Shuang and Tang Daolin stand out as the most productive authors in this field. The journal Cell Death & Disease leads in terms of publication volume, having published the greatest number of articles related to this area. This study identified hepatocellular carcinoma, mitochondrial diseases, and iron overload as the most prominent diseases explored in this research domain. Conclusion: This meticulous scientometric assessment is beneficial to both experienced researchers and newcomers by providing essential information and facilitating the derivation of innovative concepts in this field.
    Keywords:  epigenetics; ferroptosis; post-translational modifications; scientometrics; visualization analysis
    DOI:  https://doi.org/10.7150/ijms.104222
  52. Nurs Outlook. 2025 Feb 05. pii: S0029-6554(25)00013-2. [Epub ahead of print]73(2): 102360
    Reimagining policy visibility: Bibliometric analysis of core nursing journals.
    Ruth Ludwick, Margarete L Zalon, Rebecca M Patton, Micaela McSpadden, Anita J Slack, Kristin Baughman.
       BACKGROUND: Providing nurses with knowledge about policy enhances their involvement in policymaking. Policy inclusion in editorial guidelines has yet to be examined.
    PURPOSE: Describe how peer-reviewed nurse journals' editorial information communicates policy expectations to readers and authors and then to describe policy in articles published in those journals.
    METHODS: Using a list of nursing journals indexed in CINAHL, we analyzed each journal's author guidelines and key attributes. Journals that addressed policy guidelines were examined for articles that denoted policy as the subject focus, and the research team descriptively analyzed those articles.
    FINDINGS: Only half the journals included policy as a focus (aim, scope, or description), author guidelines, or column. Within this subset of journals, only 267 articles published in 2022 out of 4,085 (5.6%) had policy as a subject focus.
    DISCUSSION: Consistently and regularly addressing policy in nursing journals may facilitate nurse authors' dissemination and reader awareness about policy.
    Keywords:  Advocacy; Author guidelines; Bibliometric; Editorial policies; Health policy; Nursing
    DOI:  https://doi.org/10.1016/j.outlook.2025.102360
  53. Women Health. 2025 Feb;65(2): 208-218
    National institutes of health: Analysis of gender differences in anesthesiology research funding.
    Mah I Kan Changez, Amolpreet S Toor, Maida Tiwana, Sarmad Masud, Denise J Wooding, Faisal Khosa.
      Although studies have shown an increase in the representation of women in academic anesthesiology, it remains one of the medical specialties most dominated by men. While gender disparities have been identified in academic anesthesiology, literature on discrepancies in funding allocated by the National Institutes of Health (NIH) is scarce. The objective of the present study was to explore these discrepancies from 2017 to 2020 and assess potential changes in funding trends over time. Publicly available funding data was retrospectively obtained from the NIH Research Portfolio Online Reporting Tools Expenditure and Results (RePORTER) database for fiscal years 2017 to 2020. Information regarding each principal investigator (PI) was obtained from the Scopus database and institutional websites. For statistical comparison of continuous variables, Mann-Whitney U tests were performed. Simple linear regression analyses assessed the relationship between fiscal year and number of NIH grants awarded to PIs. Median NIH amount per grant [interquartile range (IQR)] was determined to be $359,038 ($233,947-$476,933) for PIs that were men, greater than that of $330,865 ($164,268-$458,785) for PIs that were women (p < .05). Similarly, men received a greater median NIH grant amount per PI, with a value of $348,751 ($222,043-$442,075), compared to women who received $268,634 ($161,159-$414,384) (p < .05). When stratified by terminal degree, significantly higher median grant amounts (p < .05) were awarded to MD and PhD holders who were men versus their women counterparts. Lastly, an increasing trend in obtaining NIH grants between 2017 and 2020 was observed for PIs that were men overall, including PIs holding MD/PhD degrees (p < .05). No such trend was observed for PIs who were women. This study demonstrates a significantly greater number of NIH grants and higher award values allocated to researchers who were men than researchers who were women in academic anesthesiology over the past four years. Moreover, an increase in the number of grants secured by PIs who were women from 2017-2020 was not observed. In the future, longitudinal trends in NIH funding for principal investigators (PIs) of both genders in anesthesiology should be investigated.
    Keywords:  ANesthesiology; NIH; equity; funding; gender; inclusion; representation
    DOI:  https://doi.org/10.1080/03630242.2025.2460664
  54. Heliyon. 2025 Feb 15. 11(3): e41822
    Methodological framework for supporting phytochemical bioprospecting re-search: A case study on carrot (Daucus carota L.) crop by-products.
    Jaison Martínez-Saldarriaga, Juan Camilo Henao-Rojas, Diego Hernando Flórez-Martínez, Edith Marley Cadena-Chamorro, Diana Paola Yepes-Betancur.
      Carrots are among the most crucial and globally preferred vegetables, widely recognized for their importance as a source of phytonutrients, including phenolic compounds, carotenoids, polyacetylenes, and ascorbic acid. However, its production phase incurs substantial losses, estimated at 30 %; these discarded carrots typically find application in animal feed, composting material or organic waste. Therefore, this study aims to develop a methodological framework focusing on the application of a phytochemical bioprospecting process based on scientific surveillance; using carrot crop by-products as a foundational example. Advanced methodologies, such as bibliometric, scientometric, and patent analyses, supported by technological tools such as VOSviewer and Patent Inspiration, were employed. This involved the creation of scientific landscapes, trend maps and co-occurrence networks, intending to explore the potential of carrot crop by-products, their applicability in generating new knowledge, and their utilization in the industry. This approach facilitated the identification of emerging trends in scientific research, providing a comprehensive view of commercial and industrial areas of interest, with a focus on circular economic principles. Furthermore, the study emphasized the importance of bioprospecting, supported by these methodologies and technological tools, as a key factor in the research process on the potential uses of carrot crop by-products, which could extend to other matrices.
    Keywords:  Bibliometric analysis; Bioprospecting; By-product; Carrot; Circular economy; Patent analysis; Scientific surveillance; Scientometric analysis
    DOI:  https://doi.org/10.1016/j.heliyon.2025.e41822
  55. Int J Med Sci. 2025 ;22(3): 528-550
    Research Trends and Dynamics in Single-cell RNA Sequencing for Musculoskeletal Diseases: A Scientometric and Visualization Study.
    Siyang Cao, Yihao Wei, Yaohang Yue, Deli Wang, Ao Xiong, Jun Yang, Hui Zeng.
      Background: Worldwide, approximately 1.7 billion people are afflicted with musculoskeletal (MSK) diseases, posing significant health challenges. The introduction of single-cell RNA sequencing (scRNA-seq) technology provides novel insights and approaches to comprehend the onset, progression, and treatment of MSK diseases. Nevertheless, there is a remarkable lack of analytical and descriptive studies regarding the trajectory, essential research directions, current research situation, pivotal research focuses, and upcoming perspectives. Therefore, the aim of this research is to present a comprehensive overview of the advancements made in scRNA-seq for MSK disorders over the past 15 years. Methods: It utilizes a robust dataset derived from the Web of Science Core Collection, encompassing January 1, 2009, through September 6, 2024. To achieve this, advanced analytical methodologies were applied to conduct thorough scientometric and visual analyses. Results: The findings underscore the preeminent role of China, which contributes 63.49% of the total publications, thereby exerting a substantial impact within this research domain. Notable contributions came from institutions such as Shanghai Jiao Tong University, Sun Yat-sen University, and Harvard Medical School, with Liu Yun being the leading contributor. Frontiers in Immunology published the greatest number of research papers in this field. This study identified joint diseases, bone neoplasms, bone fractures, and intervertebral disc degeneration as the main research focuses. Conclusion: This extensive scientometric analysis provides substantial benefits to both experienced and novice researchers by facilitating immediate access to critical data, thereby fostering innovation within this field.
    Keywords:  current frontiers; knowledge mapping; musculoskeletal diseases; publication hotspots; scRNA-seq; scientometrics
    DOI:  https://doi.org/10.7150/ijms.104697
  56. J Nanobiotechnology. 2025 Jan 31. 23(1): 70
    A bibliometric analysis of hydrogel research in various fields: the trends and evolution of hydrogel application.
    Zhong-Zhu Yuan, Yu-Zhou Fan, Shao-Jun Cheng, Feng-Jie Wei, Jing Gao, Chen-Xi Wang, Bo-Shuang Song, Si-Lu Tan, Si-Lian Gao, Juan-Juan Kang, Yan Liu, Sheng-Hong Li.
      Hydrogel, a polymer material with a three-dimensional structure, has considerably expanded in research across multiple fields lately. However, the lack of a comprehensive review integrating the research status of hydrogel across diverse fields has hindered the development of hydrogel. This bibliometric analysis reviewed the hydrogel-related research over the past decades, emphasizing the evolution, status, and future directions within a multitude of fields, such as materials science, chemistry, polymer science, engineering, physics, biochemistry molecular biology, pharmacology pharmacy, cell biology, biotechnology applied microbiology, etc. We encapsulated applications and the potential of hydrogel in wound healing, drug delivery, cell encapsulation, bioprinting, tissue engineering, electronic products, environment applications, and disease treatment. This study integrated the current matrix system and characteristics of hydrogels, aiming to offer a cross-field reference for hydrogel researchers and promote the advancement of hydrogel research. Furthermore, we proposed a novel and reproducible bibliometric research paradigm, which can provide a more comprehensive analysis of the trends and trajectory of a research field.
    Keywords:  Application; Bibliometric; Characteristics; Hydrogel; Matrix system
    DOI:  https://doi.org/10.1186/s12951-025-03090-x
  57. Ind Psychiatry J. 2024 Jul-Dec;33(2):33(2): 234-238
    Should premenstrual syndrome and premenstrual dysphoric disorder coexist in diagnostic manuals: Exploring the answer through citation analysis.
    Sayanti Paul, Arghya Pal.
       Background: Premenstrual syndrome (PMS) and premenstrual dysphoric disorders (PMDDs) both represent the most studied premenstrual disorders. Most studies have substantial prevalence of both PMS and PMDD, though the current understanding of the disorders reflects that PMDD is the more severe disorder of the two. However, there is substantial overlap in the etiopathogenesis and treatment approach of both these disorders.
    Aim: The current study thus explored trends of the use of PMS and PMDD as diagnostic entities.
    Materials and Methods: The study was conducted using Harzing's Publish or Perish for identifying top 50 cited articles on PMS and PMDD, published between 2013 and 2023. The search and the citation metrics were obtained from Google Scholar through the mentioned software. The citation metrics of the two groups of studies were compared, and appropriate statistical maneuvers were used.
    Results: The PMS studies had a higher mean number of citations than PMDD studies. The PMDD studies tended to have a higher number of authors from Psychiatry or related background. The PMDD studies also had higher representation of institutions from the United States of America.
    Conclusion: Using citation analysis to study the utilization trends of diagnostic label is a novel approach. This study shows that there is a need for a unique diagnostic entity to represent the premenstrual disorders, and the coexistence of PMS and PMDD is redundant.
    Keywords:  Citation analysis; nosology; premenstrual disorder; premenstrual dysphoric disorder; premenstrual syndrome
    DOI:  https://doi.org/10.4103/ipj.ipj_4_24
  58. J Am Acad Orthop Surg. 2025 Feb 04.
    Characteristics of Abstracts Presented at the American Academy of Orthopaedic Surgery Annual Meeting and Their Impact on Publication Rates.
    Jose I Acosta Julbe, Marcos R Gonzalez, Kishore Konar, Ava Macchia, Alexandra Santos, Jinjaemin Yoon, Josue Layme, Antonia F Chen.
       INTRODUCTION: The publication rate of abstracts presented at the American Academy of Orthopaedic Surgeons (AAOS) Annual Meetings has increased over the past 15 years. The purpose of this study was to (1) analyze and describe the characteristics of abstracts presented at the 2022 and 2023 AAOS Annual Meetings and (2) evaluate whether certain factors were associated with a higher likelihood of publication.
    METHODS: A retrospective analysis of all abstracts presented at the 2022 and 2023 AAOS Annual Meeting was done based on the AAOS ePosters archive. PubMed and Google Scholar databases were searched to determine whether the abstract had been followed by publication in a peer-reviewed journal within 1 year of presentation.
    RESULTS: A total of 1,987 abstracts were presented at the AAOS Annual Meeting; most were in adult reconstruction (30.1%), and 44% were published. Most studies had a level of evidence of III (71%), and the use of large databases increased between years (9.4% to 13%). Foot and ankle exhibited the highest publication rates among AAOS subspecialties (61%). Abstracts that were published had a markedly higher sample size and a higher rate of men as first authors (P < 0.001). Hand and wrist (30%) and practice management and rehabilitation (25.8%) had the highest rates of women as first and senior authors, respectively.
    CONCLUSION: We found that 44% of the abstracts presented at the 2022 and 2023 AAOS Annual Meetings resulted in publication. Although most abstracts were in adult reconstruction, foot and ankle had the highest publication rate.
    LEVEL OF EVIDENCE: III.
    DOI:  https://doi.org/10.5435/JAAOS-D-24-00487
  59. J Cosmet Dermatol. 2025 Feb;24(2): e16770
    Evolutionary Trends and Research Focal Points on Port Wine Stains: A Scientometric and Meta-Analysis.
    Zheren Su, Xuanfeng Chen, Rui Zhang, Jing Li, Zifu Zhou, Jianhai Bi, Ran Huo.
       BACKGROUND: Despite numerous studies over the past two decades, clinical treatment for port wine stains (PWS) has shown limited progress. Analyzing evolutionary trends and research focal points can illuminate current deficiencies and guide future investigations. We aim to conduct a scientometric analysis and meta-analysis to uncover the historical trajectory, research hotspots, and future directions of PWS.
    METHODS: We conducted a scientometric analysis of articles related to PWS published between 2000 and 2023. Data were retrieved from the Web of Science Core Collection (WoSCC) and analyzed using R software, VOSviewer, and CiteSpace. Furthermore, we retrieved articles reporting therapeutic clearance rates for PWS from PubMed, Embase, Web of Science, and Cochrane search engines. A meta-analysis was performed using Stata/MP to assess whether treatment outcomes for PWS have improved in the 21st century.
    RESULTS: The annual scientific output was stable from 2000 to 2023. The top three countries in terms of document production were the United States, China, and the United Kingdom. Pulsed dye laser (PDL) and photodynamic therapy (PDT) were the two primary modalities used in the treatment of PWS. A notable difference exists in the preference for these treatment modalities between China and Western countries. The meta-analysis shows improvement in treatment outcomes for PWS from 2000 to 2023.
    CONCLUSIONS: Although limited, treatment outcomes for PWS have shown improvement in the 21st century. However, there is a critical need for research directions that could revolutionize current treatment practices. Genetic discoveries have suggested promising therapeutic targets for potential breakthroughs in the future.
    Keywords:  bibliometrics; meta‐analysis; port wine birthmarks; vascular anomalies
    DOI:  https://doi.org/10.1111/jocd.16770
  60. Sci Eng Ethics. 2025 Feb 05. 31(1): 6
    Discussions on Human Enhancement Meet Science: A Quantitative Analysis.
    Tomasz Żuradzki, Piotr Bystranowski, Vilius Dranseika.
      The analysis of citation flow from a collection of scholarly articles might provide valuable insights into their thematic focus and the genealogy of their main concepts. In this study, we employ a topic model to delineate a subcorpus of 1,360 papers representative of bioethical discussions on enhancing human life. We subsequently conduct an analysis of almost 11,000 references cited in that subcorpus to examine quantitatively, from a bird's-eye view, the degree of openness of this part of scholarship to the specialized knowledge produced in biosciences. Although almost half of the analyzed references point to journals classified as Natural Science and Engineering (NSE), we do not find strong evidence of the intellectual influence of recent discoveries in biosciences on discussions on human enhancement. We conclude that a large part of the discourse surrounding human enhancement is inflected with "science-fictional habits of mind." Our findings point to the need for a more science-informed approach in discussions on enhancing human life.
    Keywords:  Biosciences; Citation analysis; Enhancement; Topic modeling
    DOI:  https://doi.org/10.1007/s11948-025-00531-6
  61. Front Med Technol. 2024 ;6 1382316
    Bibliometrics of the current state of application of teletechnology in the rehabilitation of patients with heart and large blood vessel disease.
    Sican Wang, Ping Yu, Xuemei Zhou, Yuan Yuan, Jian Chen, Dongmei Chen, Jingyan Liang, Li Xu.
      The first publication on the use of teletechnology in heart and large blood vessels dates back to 1961. Since then, the study of teletechnology in heart and large blood vessels has become popular, and the number of publications has drastically increased. Hence, it is imperative to establish a comprehensive research framework that enables researchers and other stakeholders to understand the use of remote technologies in heart and large blood vessels. To bridge this gap, bibliometrics was used, a novel approach to determine the most prolific countries, institutions, journals, authors, source topics, funding agencies, and the most popular category of remote technologies and solutions for disease rehabilitation. The corpus was extracted from the WOS core database and analyzed using CiteSpace 6.2R7 and VOS Viewer 1.6.18 versions. The number of publications has grown since the start of the 21st century, with the United States, the United Kingdom, and Italy being the most productive nations. The most commonly used remote technology was a 24 h dynamic electrocardiogram (ECG) and ambulatory blood pressure monitoring. The most researched objective indicators were heart rate, blood pressure, and cardiac output. The primary research focused on daily life, physical activity, exercise endurance, and quality of life. Moreover, heart failure and coronary artery disease were the most extensively researched diseases.
    Keywords:  bibliometrics; cardiac rehabilitation; cardiac surgery; heart disease; rehabilitation; telemetry; teletechnology
    DOI:  https://doi.org/10.3389/fmedt.2024.1382316
  62. Front Psychol. 2024 ;15 1448555
    A systematic literature review on digital literacy, employability, and innovative work behavior: emphasizing the contextual approaches in HRM research.
    Angela Caroline, Martine J H Coun, Agus Gunawan, Jol Stoffers.
      Knowledge Society 5.0 and Industry 5.0 require workers with adaptable employability skills and who engage in innovative work behavior that help companies to create innovative products and processes that are difficult for competitors to imitate. Extant research examines employability, and innovative work behavior, but there are still few articles that include digital literacy in their study. In fact, digital literacy is closely related to human resources in the new workforce whose daily activities are closely related to digital technology. Through bibliometric analysis and a systematic literature review of the interplay among digital literacy, employability, and innovative work behavior we synthesize research trends, measurements, theoretical frameworks, and conceptual models on these topics. In addition, some contextual considerations will be utilized to ensure accurate data interpretation. Findings suggest that there is no generic measure of digital literacy, especially in business contexts, that links this concept to either employability or innovative work behavior. Digital literacy is particularly important to increase employability and stimulate both innovative behavior and performance. Future research should explore these topics using various methodologies and theoretical frameworks, combining them with multiple perceptions across workers and countries, especially considering the pace of technological development.
    Keywords:  bibliometric analysis; contextual approaches; digital literacy; employability; innovative work behavior; systematic literature review
    DOI:  https://doi.org/10.3389/fpsyg.2024.1448555
  63. Nature. 2025 Jan 31.
    Thousands of highly cited scientists have at least one retraction.
    Jackson Ryan.
      
    Keywords:  Authorship; Publishing; Scientific community
    DOI:  https://doi.org/10.1038/d41586-025-00257-2
  64. Asian Bioeth Rev. 2025 Jan;17(1): 43-57
    Gender Diversity in the Editorial Boards of Global Obstetrics and Gynecology Journals.
    Seema Rawat, Pratyush Kumar, Lovish Wadhwa.
      Gender representation in academic and professional settings is crucial for diversity and inclusivity. Editorial boards of scholarly journals shape research priorities, influencing global knowledge flow. In obstetrics and gynecology, with a focus on women's health, board composition is of particular significance. This paper explores gender representation in international obstetrics and gynecology journal editorial boards, addressing potential disparities. The study adopts a cross-sectional design, analyzing the gender composition of editorial boards in global obstetrics and gynecology journals. A comprehensive search strategy identified relevant journals, using databases and manual searches. Inclusion criteria ensured journals' language of use and disciplinary scope within obstetrics and gynecology. Ethical considerations prioritized privacy and confidentiality, with data extracted systematically. Genderize.io aided in gender determination of the board members. At the time of writing, among 1175 editorial members from 20 journals, 44.8% are females. Representation varies across roles: editor-in-chief (27.27% female), deputy/executive positions (43.33% female), senior/specialized positions (50.66% female), wider/general positions (45.89% female), nonacademic positions (36% female), external academic positions (19.56% female), honorary/founding positions (33.33% female), and administrative positions (31.03% female). This study contributes a comprehensive analysis of gender representation in obstetrics and gynecology journal editorial boards. Persistent disparities across roles underscore the need for targeted interventions to foster diversity and equity. Ethical considerations emphasize the importance of addressing these disparities for social justice and research integrity. Recommendations to guide journals in fostering inclusive editorial practices, contributing to a more equitable landscape in obstetrics and gynecology research.
    Keywords:  Editorial boards; Ethics; Gender diversity; Gynecology; Obstetrics; Professionalism
    DOI:  https://doi.org/10.1007/s41649-024-00298-1
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