bims-evares Biomed News
on Evaluation of research
Issue of 2024–11–17
120 papers selected by
Thomas Krichel, Open Library Society



  1. Curr Probl Cardiol. 2024 Nov 05. pii: S0146-2806(24)00558-9. [Epub ahead of print]50(1): 102923
      The primary objective of this study was to conduct a bibliometric analysis of the most influential papers on ST-Elevation Myocardial Infarction (STEMI). Using the Scopus database (October 2024), a targeted search was performed to identify relevant publications. Three retrieval options were considered based on the appearance of search terms. Precisely those documents were analyzed where the search terms appeared only in the title, allowing for a focused analysis of the most directly relevant studies. Next, from this search, the top 100 most cited papers, spanning from 1981 to 2018, were selected for detailed examination. Data analysis was conducted using VOSviewer and R Studio to provide insights into publication trends, author productivity, and the thematic focus of STEMI research. Author performance was evaluated through various bibliometric indicators, including total publications (TP), total citations (TC), h-index, g-index, m-index, HG composite, and Q2 index. Key metrics such as mean total citations per article (MeanTCperArt) and mean annual citation rate (MeanTCperYear) were also calculated. Thematic analysis of research topics was conducted using unigrams, bigrams, and trigrams, highlighting primary areas of focus across the most impactful STEMI studies. The results underscore significant trends in STEMI research, with highly cited papers shaping the field's evolution. This bibliometric approach provides valuable insights into research patterns, major contributors, and prevalent themes within STEMI literature.
    Keywords:  Author performance: Co-words analysis; Bibliometric analysis; Citation analysis; ST-elevation myocardial infarction (STEMI)
    DOI:  https://doi.org/10.1016/j.cpcardiol.2024.102923
  2. World Neurosurg. 2024 Nov 08. pii: S1878-8750(24)01840-0. [Epub ahead of print]
       BACKGROUND: Middle meningeal artery embolization (MMAE) is an endovascular technique that has been rapidly adopted in the management of chronic subdural hematoma (cSDH), with numerous positive results across the literature. This study aimed to summarize the body of original research published on MMAE for the treatment of cSDH through bibliometric methods.
    METHODS: The Web of Science, Science Citation Index Expanded database was queried on October 1, 2024 for articles related to MMAE for cSDH. The title, abstract, authors, publication year, journal, keywords, institution of first author, author keywords, and citations of studies were extracted for bibliometric analysis. Bibliometric visualizations were performed using VOSviewer version 1.6.20 and other visualizations were made in Graphpad Prism version 9.4.0. Overlay visualizations depicting average year of article output were selectively constructed to further elucidate trends in authorship.
    RESULTS: The study retrieved 198 publications on MMAE to be included in analysis. There was an exponential increase in both the number of published studies and the number of citations over the timeframe. The author, country, institution, and journal that contributed the most to the field were Christopher S. Ogilvy, the United States of America, Harvard Medical School, World Neurosurgery respectively. The most recent groupings on keyword analysis as of 2023 includes "subdural", "liquid embolic material", "embolic", and "hemorrhage".
    CONCLUSION: As the popularity of MMAE and power of studies related to the technique continues to rise, we hope that this analysis can continue to guide clinicians and researchers on growing areas of interest and academic hotspots of collaboration.
    Keywords:  bibliometric analysis; chronic subdural hematoma; middle meningeal artery embolization
    DOI:  https://doi.org/10.1016/j.wneu.2024.10.136
  3. Heliyon. 2024 Nov 15. 10(21): e39806
      This bibliometric analysis reviews 8521 articles related to the digitalization of higher education, spanning from 1968 and 2023, sourced from the Web of Science Core Collection (WoSCC), PubMed, and Scopus databases. Employing this analytical framework, we identify key authors, leading institutions, and influential countries while highlighting high-impact literature and intricate collaborative networks within this field. Through an examination of high-frequency keywords and topics, this study maps the knowledge structure of the field, suggesting emerging hotspots and setting the trajectories for future research directions. Notably, the study by Crawford et al., in 2020 has received the highest number of citations, marking a significant impact. Furthermore, Spain has been particularly active, emerging as a leader in the volume of contributions to digital research in higher education. Keywords such as "co-creation", "competency", "hybrid teaching", and "digital writing" are identified to drive future research trends, reflecting a growing interest in these areas. Meanwhile, themes like "e-learning" and "blended learning" are expected to remain central in upcoming research work.
    Keywords:  Bibliometrics; Biblioshiny; Digitalization; Higher education; Research hotspots
    DOI:  https://doi.org/10.1016/j.heliyon.2024.e39806
  4. Front Oncol. 2024 ;14 1484074
       Background: Gynecological cancers (GC) pose a severe threat to the health and safety of women's lives, and organoids, as in-vitro research models, have demonstrated significant advantages in simulating tissue characteristics and drug screening. In recent years, there has been a rapid increase in research outcomes related to organoids in GC. However, there has been no bibliometric study concerning.
    Methods: Publications related to GC and organoids from 2010-2023 were retrieved from the Web of Science Core Collection (WoSCC). We conducted a bibliometric analysis and visualization using CiteSpace, VOSviewer, and the Bibliometrix R Package. This analysis included the spatiotemporal distribution, author, sources, references, and keywords.
    Results: A total of 333 publications were included. The number of annual publications indicated an explosive phase of development since 2019. The USA was the most important country in terms of cooperation, publication output, citation and centrality. University of California system ranked first in productivity among institutions, and HIPPO Y is the most relevant author in the research field. CANCERS published the most documents, and NATURE is the most cited sources. Analysis of Keywords and References, it is possible to establish the trend, and find the hotspots in the research field.
    Conclusion: This bibliometric analysis delineated global landscapes and progress trends in GC organoids research. This study emphasized that organoids can effectively replicate the original tissue or tumors, providing a good in-vitro model for research on tumor-related mechanisms and showing significant advantages in drug screening and efficacy clinical prediction. Additionally, as preclinical models, they provide compelling evidence for personalized therapy and prediction of patient drug responses.
    Keywords:  bibliometric analysis; cervical cancer (CC); endometrial cancer (EC); gynecological cancers (GC); organoids; ovarian cancer (OC)
    DOI:  https://doi.org/10.3389/fonc.2024.1484074
  5. Hematology. 2024 Dec;29(1): 2427896
       BACKGROUND: The application of traditional Chinese medicine (TCM) therapy to acute leukemia has been intensively investigated. However, the bibliometric analysis in this field has not been performed. This bibliometric study aimed to comprehensively analyze the research trends and active areas of TCM therapy for acute leukemia from 2000 to 2023.
    METHODS: We searched articles and reviews published between 2000 and 2023 that discussed TCM in acute leukemia from the Web of Science Core Collection (WoSCC). Knowledge mapping and bibliometric analysis were conducted using VOSviewer, CiteSpace software, and R-bibliometrix.
    RESULTS: A total of 1,099 articles were included, with China, the United States, and Korea contributing the most papers. Most papers were published in the Journal of Ethnopharmacology. Meanwhile, China saw a steady increase in the number of publications. The three leading institutions that made outstanding contributions were the China Medical University, the Chinese Academy of Sciences, and the China Academy of Chinese Medical Sciences. Efferth Thomas, Liu Wei, and Liu Jie were the top three productive authors, with Efferth T receiving the most co-citations. The most frequently cited reference was Shen ZX (1997). In the analysis of keywords co-occurrence, 'survival,' 'risk factors,' 'nanoparticles,' and 'metabolism' are the active research topics.
    CONCLUSION: This bibliometric study provides researchers with a comprehensive overview and significant value in understanding the development of TCM in acute leukemia treatment.
    Keywords:  Traditional Chinese medicine; VOSviewer; acute leukemia; bibliometrics; research trends
    DOI:  https://doi.org/10.1080/16078454.2024.2427896
  6. Front Hum Neurosci. 2024 ;18 1486167
       Background: Although the application of brain-computer interface (BCI) technology in rehabilitation has been extensively studied, a systematic and comprehensive bibliometric analysis of this area remains lacking. Thus, this study aims to analyze the research progress of BCI technology in rehabilitation through bibliometric methods.
    Methods: The study retrieved relevant publications on BCI technology in rehabilitation from the Web of Science Core Collection (WoSCC) between January 1, 2004, and June 30, 2024. The search was conducted using thematic queries, and the document types included "original articles" and "review articles." Bibliometric analysis and knowledge mapping were performed using the Bibliometrix package in R software and CiteSpace software.
    Results: During the study period, a total of 1,431 publications on BCI technology in rehabilitation were published by 4,932 authors from 1,281 institutions across 79 countries in 386 academic journals. The volume of research literature in this field has shown a steady upward trend. The United States of America (USA) and China are the primary contributors, with Eberhard Karls University of Tübingen being the most active research institution. The journal Frontiers in Neuroscience published the most articles, while the Journal of Neural Engineering was the most cited. Niels Birbaumer not only authored the most articles but also received the highest number of citations. The main research areas include neurology, sports medicine, and ophthalmology. The diverse applications of BCI technology in stroke and spinal cord injury rehabilitation, as well as the evaluation of BCI performance, are current research hotspots. Moreover, deep learning has demonstrated significant potential in BCI technology rehabilitation applications.
    Conclusion: This bibliometric study provides an overview of the research landscape and developmental trends of BCI technology in rehabilitation, offering valuable reference points for researchers in formulating future research strategies.
    Keywords:  CiteSpace; bibliometric analysis; brain-computer interface; hotspots and trends; rehabilitation
    DOI:  https://doi.org/10.3389/fnhum.2024.1486167
  7. Front Neurol. 2024 ;15 1464048
       Background: Extensive research has been conducted worldwide on non-specific low back pain (NSLBP), some researchers published a bibliometric analysis of NSLBP in 2020, but there have been no supplements or updates since then. Therefore, this study aimed to analyze the research hotspots and frontiers in NSLBP over the last decade.
    Methods: Primary sources on NSLBP were obtained from the Web of Science Core Collection database from 2014 to 2023. CiteSpace V6.2. R7 (64-bit) and VOSviewer 1.6.19 software were used to analyze the number and centrality of journals, countries, institutions, authors, references, and keywords, and the functions of co-occurrence and clustering were applied to draw a visual knowledge map.
    Results: In the past decade, the annual publication volume of studies on NSLBP has shown an overall upward trend year by year, with obvious temporal stages and great development potential. In total, 2,103 articles contained six types of literature, with the highest proportion being original research articles (1,633 articles, 77.65%), published in 200 journals. BMC Musculoskeletal Discourses (90 articles, 4.28%) had the highest number of publications, and the British Medical Journal had the highest impact factor (105.7). Furthermore, the United States of America (329 articles, 15.64%) had the highest publication volume, the University of Sydney (139 articles, 6.61%) was the research institution with the highest production, Maher, Chris G (36 articles, 1.71%) was the author with the most published articles, and Hoy, D (571 articles, 27.15%) was the most frequently cited author. The most cited of articles is "Non-specific low back pain" published in the LANCET, with 1,256 citations.
    Conclusion: This article summarizes the current research status of NSLBP and predicts future research hotspots and frontiers. In recent years, adolescents have become a high-risk group for NSLBP. Pain neuroscience education, motor control, spinal manipulative therapy, and acupuncture are effective means to treat NSLBP. Biomechanics and trunk muscles as entry points are effective ideas for the treatment of NSLBP pain. Furthermore, anxiety, neck pain, non-specific musculoskeletal pain, fibromyalgia, and musculoskeletal disorders are diseases that are closely related to NSLBP. In the future, attention should be paid to the design of research plans, increasing the research intensity of randomized controlled trials, strengthening follow-up, and the timely updating of guidelines, which will result in higher quality and high-level scientific evidence for research on NSLBP.
    Keywords:  CiteSpace; bibliometrics; frontiers; hotspots; non-specific low back pain
    DOI:  https://doi.org/10.3389/fneur.2024.1464048
  8. Oral Oncol. 2024 Nov 13. pii: S1368-8375(24)00412-3. [Epub ahead of print]159 107094
       OBJECTIVE: Oral cancer refers to a group of malignancies. The disease's complexity requires a multidisciplinary approach, encompassing oncology, dentistry, epidemiology, molecular biology, and other fields. Given this multifaceted nature, bibliometrics has emerged as a crucial tool to navigate the vast array of academic literature surrounding oral cancer.
    METHOD: 82 highly cited publications on oral cancer were collected based on the Web of Science Core Collection. For bibliometric visualization and analysis, VOSviewer and R software (4.3.0 version) were used to explore publication trends, collaboration networks, core journals, research hotspots and authors in the field of oral cancer.
    RESULTS: This study analyzed 82 publications published over the past 11 years, including 46 published in the United States, 17 in China, 17 in UK, 12 in Canada and 10 in India. Quynh-Thu Le had the most publications (4 publications). Burtness B was the most cited author with 1,926 citations. University of Texas MD Anderson Cancer Center was the most active institution by contributing 7 publications. The most productive journal was journal of clinical oncology. Cluster Analysis of Co-occurrence Keywords revealed that top 10 highest number of core words were squamous-cell carcinoma, cancer, human-papillomavirus, survival, united-states, oropharyngeal cancer, risk, epidemiology, head and risk-factors.
    CONCLUSION: Over the past 11 years, studies of oral cancer are increasingly. This bibliometric study may aid researchers in the understanding of the knowledge base and research frontiers associated with oral cancer. Emerging hotspots for research can be used as the subjects of future studies.
    Keywords:  Bibliometric; Highly cited publication; Oral cancer; R software; VOSviewer
    DOI:  https://doi.org/10.1016/j.oraloncology.2024.107094
  9. J Cosmet Dermatol. 2024 Nov 11.
       BACKGROUND: Acne vulgaris is a chronic inflammatory skin condition, commonly resulting in acne scars. Treating acne scars remains a significant challenge in dermatology. With advancements in laser technology, its clinical use for treating acne scars has been increasing annually. However, bibliometric analysis on laser treatment for acne scars is lacking. This study aims to use bibliometrics to comprehensively understand the development trends and research hotspots in laser treatment for acne scars.
    METHODS: Using "acne scar" and "laser" as search terms, literature on laser treatment of acne scars from 2014 to 2024 was retrieved from the Web of Science Core Collection (WoSCC) database. The literature data were visualized using VOSviewers, CiteSpace, and R software, generating maps of countries, research institutions, authors, journals, references, and keywords.
    RESULTS: The analysis included 536 articles from 46 countries, with the United States and China leading in publications. Publications focusing on laser treatment of acne scars exhibit a consistent growth trend annually. Key research institutions include Mahidol University in Thailand, Cairo University in Egypt, and Hallym University in South Korea. The "Journal of Cosmetic Dermatology" had the highest number of articles in this field, while "Dermatologic Surgery" was the most cited publication. These publications involved contributions from 2135 authors, with Professor Manuskiatti Woraphong from Mahidol University in Thailand being the most prolific author in this field. Research on the efficacy of laser treatment for acne scars is a major focus in this field. Among the different types of lasers, CO2 lasers are the most commonly used. Emerging research focuses include therapies such as platelet-rich plasma, picosecond laser, trichloroacetic acid, and burn scar.
    CONCLUSIONS: Treatment efficacy is the primary focus of research in the field of laser treatment for acne scars. Platelet-rich plasma, and novel picosecond lasers, have emerged as hot topics and trends in this research field. However, it is important to note that the impact factors of journals publishing in this field are currently low. Therefore, clinicians must consider and explore strategies for publishing high-quality clinical research in the future.
    Keywords:  VOSviewer; acne scar; bibliometrics; citespace; laser
    DOI:  https://doi.org/10.1111/jocd.16663
  10. Hum Vaccin Immunother. 2024 Dec 31. 20(1): 2426869
      Cellular immunotherapy has shown considerable potential for the treatment of primary liver cancer (PLC), particularly hepatocellular carcinoma (HCC), although it is in the early stages of development. This study used bibliometric methods to delineate the evolution of research on cellular immunotherapy for PLC. Data were sourced from the Web of Science Core Collection (WoSCC) on April 22, 2024. Using the "Bibliometrix" R package, we examined primary bibliometric features, collaboration frequency between countries, and article output of the journals. Furthermore, we employed VOSviewer for coauthorship analysis and visualization and CiteSpace to assess keyword co-occurrence, as well as to spotlight keywords and references with the strongest citation bursts. Our analysis encompassed 492 publications focused on PLC and cellular immunotherapy, and we pinpointed China, Japan, and the USA as the foremost contributing nations and identified "Cancer Immunology Immunotherapy" as the journal with the most contributions in this area. Sun Yat-sen University emerged as the institution with the most significant output, and Li Zonghai authored the greatest number of leading articles. Prominent keywords that displayed a notable citation burst in the later years included "chimeric antigen receptor," "combination therapy", "CAR-T cells," "TCR-T cells," and "liver transplantation." This bibliometric study outlined a foundational knowledge framework, surveyed over three decades of research on cellular immunotherapy for PLC, and revealed the key players and trends, thereby offering a thorough understanding of the field, especially in relation to HCC.
    Keywords:  Bibliometric; cellular immunotherapy; hotspot; primary liver cancer; trends
    DOI:  https://doi.org/10.1080/21645515.2024.2426869
  11. Front Med (Lausanne). 2024 ;11 1465893
       Background: In recent years, extensive research has been conducted on endometrial receptivity (ER), with rapidly evolving research hotspots and trends. Our study aimed to explore the development of ER research from 2000 to the present and provide insights for future endeavors.
    Materials and methods: Relevant research publications on ER from 2000 to 2024 were retrieved from the Web of Science Core Collection (WOSCC) database. CiteSpace, VOSviewer and Excel tools were employed to conduct the bibliometric analysis.
    Results: A total of 3,354 articles were analyzed, revealing an overall upward trend in annual publication numbers, signifying the increasing attractiveness and research value of this field. Globally, China led with a notable advantage of 1,030 publications, followed by the United States (650) and Spain (251), constituting the first tier of international research. Valencia University topped the list of institutions with 108 publications, closely followed by Shanghai Jiao Tong University with 87. Fertility and Sterility (IF6.6, Q1) is the one with the largest number of publications, accounting for 7.96% of the total publications. The three most co-cited journals were Fertility and Sterility, Biology of Reproduction, and Human Reproduction. A co-citation reference analysis revealed that ER research can be categorized into ten major subfields, including embryo implantation, frozen embryo transfer, integrins, recurrent implantation failure, intrauterine adhesions, etc. Since 2020, the keywords with the strongest citation bursts include repeated implantation failure and frozen.
    Conclusion: This study employs bibliometric analysis to offer researchers in the field of ER a comprehensive perspective. Since 2000, there has been a remarkable surge in the number of publications in the ER research field. These studies primarily concentrate on delving into the pathophysiological mechanisms of ER, with the primary objective of enhancing clinical pregnancy rates and live birth rates, benefiting more infertile patients. Currently, addressing the ER issues in patients with recurrent implantation failure represents the forefront of research. The primary treatment approaches currently in use involve optimizing embryo transfer timing and employing innovative strategies such as immunotherapy. These cutting-edge analyses not only provide new insights into the treatment of ER but also offer researchers fresh research directions, and staying abreast of the latest trends and advancements in the field.
    Keywords:  VOSviewer; bibliometric analysis; citespace; endometrial receptivity; research hotspots
    DOI:  https://doi.org/10.3389/fmed.2024.1465893
  12. Hum Vaccin Immunother. 2024 Dec 31. 20(1): 2426321
      Although IL-22 has been extensively studied, a comprehensive and systematic bibliometric analysis has not yet been conducted on it. This article reviews the research progress of IL-22 using bibliometric methods. On May 20, 2024, publications related to IL-22 were identified and selected from the Web of Science Core Collection (WoSCC) database. CiteSpace and VOSviewer are beneficial for IL-22 bibliometric and knowledge graph analysis. From January 1, 2014 to December 31, 2023, 25134 authors from 4206 institutions in 106 countries published 3943 articles on IL-22 research in 940 academic journals. During this period, the number of articles steadily increased. The United States and China are the main contributors to this research field, with the most active institutions being the Medical Research Institute (INSERM) led by De la Sante et al. and the University of California system. The most prolific journal is Frontiers of Immunology, and it is also the journal with the most citations. Guttman Yassky, E. has published the most articles, and Guttman Yassky, E. is also the most frequently cited. The main areas of these publications are immunology and cell biology. After analysis, the high-frequency keywords of IL-22 research involve molecular biology (IL-17) and immune response (T cells) Th17 cells and diseases (autoimmune diseases, cancer). Among them, the involvement of interleukin-22 in microbial populations and cancer cell spread has strong research potential and is currently a hot research topic. Since 2014, IL-22 has received significant attention in scientific research as a key immune regulatory factor. China is at the forefront of research in this field, followed closely by the United States. At present, breakthrough progress is being made in the research of immunotherapy, and in-depth study of IL-22 and its signal transduction mechanisms is crucial for understanding its biological functions. Meanwhile, exploring new possibilities for IL-22 as a therapeutic target will help develop more effective treatment strategies. This study can provide scholars with research directions related to IL-22.
    Keywords:  CiteSpace; IL-22; immunity; visualization
    DOI:  https://doi.org/10.1080/21645515.2024.2426321
  13. Complement Ther Med. 2024 Nov 12. pii: S0965-2299(24)00099-2. [Epub ahead of print] 103111
       BACKGROUND: Parkinson's disease non-motor symptoms (PD-NMS) significantly affect patients' quality of life. Acupuncture has emerged as a potential complementary therapy for PD-NMS. This study aims to investigate general research status, hotspots and trends of acupuncture as a treatment for PD-NMS.
    METHODS: Literature on Web of Science Core Collection (WoSCC) from 2003 to 2023 was retrieved, and bibliometric analysis was conducted using VOSviewer and CiteSpace software.
    RESULTS: 159 publications by 894 authors from 37 countries, 300 institutions, and 96 journals were retrieved and analyzed. The number of publications in this field is generally on the rise yearly. China was the leading contributor with 57 publications, and the United States followed with 36 publications and had the highest total citation count of 1,562. Guangzhou University of Chinese Medicine ranked the highest with a total of 12 publications, while Harvard University had the highest average citation rate of 70 citations per publication. Evidence-Based Complementary and Alternative Medicine was the most prolific journal with 11 articles that had accumulated 122 citations. Park Hi-Joon was the leading contributor with seven articles and 314 citations. The keyword analysis highlighted emerging areas of interest like "deep brain stimulation" and "alpha-synuclein".
    CONCLUSION: Different countries, institutions, and authors should enhance cooperations, and the underlying mechanisms of acupuncture for PD-NMS should be demonstrated. This study will be helpful for better understanding the current knowledge and gaps in the areas of acupuncture as a treatment of PD-NMS.
    Keywords:  Acouncture; Bibliometrics; CiteSpace; Non-motor symptoms; Parkinson's disease; VOSviewer
    DOI:  https://doi.org/10.1016/j.ctim.2024.103111
  14. J Clin Exp Dent. 2024 Oct;16(10): e1170-e1182
       Background: Many studies have analysed the bibliometric characteristics of highly cited articles in dentistry, and orthodontics. However, scant attention has been paid to articles with low citation rates. The aim of this study is to identify author- and article-specific factors that may be associated with a low citation rate at least 6 years after publication.
    Material and Methods: In June 2023, a cross-sectional study was conducted on articles published between 2009 and 2018 in eight orthodontic journals indexed in the Journal Citation Report. The study recorded author- and article-specific variables for articles that received zero citations and those that received between one and three citations. Descriptive statistics were used to describe the articles and journals included in the study. Pearson's correlation analysis was used to test the correlation between a journal's impact factor and the number of low-cited articles for the individual journals. The articles' related topics were further analysed using VOSviewer 1.6.6 software.
    Results: The electronic search identified 11,257 published items. After applying the inclusion and exclusion criteria, 216 uncited and 683 poorly cited articles were included in the final assessment. The Australasian Orthodontic Journal had the highest number of uncited and poorly cited articles, followed by Seminars in Orthodontics. A high negative correlation was found between the journal impact factor and the normalized number of uncited and poorly cited articles. The majority of uncited articles were expert opinions (28.24%), case reports (21.76%), and narrative reviews (21.30%). The most frequent topics were legislation, litigation, and ethics, followed by marketing and management. Most of the poorly cited articles were observational (29.43%) or translational studies (26.21%), and case reports (22.55%). The most prevalent topic in this cohort was eruption problems.
    Conclusions: The impact factor of a journal is linked to the number of published articles that receive a low citation rate. Orthodontics has a higher prevalence of such articles compared to other branches of medicine. Topics such as litigation, legislation, ethics, and marketing tend to receive low citation rates. Uncited articles often consist of expert opinions or narrative reviews. Case reports are a common study design in both uncited and poorly cited articles. Key words:Bibliometric, Orthodontics, citations, Uncited.
    DOI:  https://doi.org/10.4317/jced.61962
  15. Front Oncol. 2024 ;14 1429194
       Background: Lung cancer has the highest fatality rate among all malignancies worldwide. Within this disease, bone metastasis (BM) emerges as a particularly deleterious site of metastatic dissemination, marked by a dismal prognosis. The objective of this investigation is to shed light on the current international research efforts and the development trajectory on lung cancer BM through a bibliometric analysis (performance and visualization analysis).
    Method: Data were obtained from the Web of Science Core Collection repository on lung cancer BM from 1 January 2012 to 1 January 2022. Subsequently, the collected data underwent scrutiny using the VOSviewer software to reveal patterns of co-authorship, co-citation, and keyword analysis, while the CiteSpace software facilitated the generation of keyword cluster maps and performed burst analyses.
    Results: The study included 327 papers of 2,154 authors, 587 organizations, and 41 countries, and explored the cooperation between them and the relationships between citations. Over the past decade, published papers showed a steady growth trend. China had the highest production with 189 papers, and USA had the highest collaboration with other countries, with 43 total link strength. Lung Cancer exhibited the highest frequency of co-cited journals, with a co-citation time of 412 and an IF/JCR partition of 6.081/Q1 in 2021. The most frequently co-cited article, authored by Tsuya A and published in Lung Cancer in 2007, amassed 70 co-citations. High-frequency keywords were categorized into four clusters: pathogenesis, treatment and clinical manifestations, prognosis, and diagnosis. In recent years, there has been a significant increase in the strong citation burst strength of keywords such as "predictor," "skeletal-related events," "efficacy," "migration," "docetaxel," and "impact." Lung adenocarcinoma is the most common type of tumor.
    Conclusion: This bibliometric study provides a comprehensive analysis of lung cancer BM in the recent 10 years. The field of early diagnosis, pathogenesis, and new treatments is entering a phase of rapid development and remains valuable for future research.
    Keywords:  bibliometrics; bone metastasis; hotspot; lung cancer; pathogenic mechanism
    DOI:  https://doi.org/10.3389/fonc.2024.1429194
  16. Animals (Basel). 2024 Oct 31. pii: 3132. [Epub ahead of print]14(21):
      The present study is an evaluation of published papers in the field of scientometrics-bibliometrics in veterinary or animal studies. The objective was the quantitative evaluation of the scientific content and the bibliometric details of papers that had used scientometrics as a methodological approach to assess various topics within the broad field of veterinary or animal studies. For the search of published papers, the Web of Science database was used; the search string {ALL FIELDS = [scientometric* OR bibliometric*]} AND {ALL FIELDS = [veterinary OR animal*]} was employed. In all, 163 papers were evaluated individually. There was a progressive increase in the number of papers published annually (slope 0.314 ± 0.063) which originated from 58 countries, mostly from the United States of America (n = 24) and 306 organizations. The databases employed most frequently for record search were the Web of Science, Scopus and PubMed (in 105, 60 and 21 papers, respectively); the median timespan of the searches was 25 years (interquartile range (IQR): 31) and the median number of records was 1082.5 (IQR: 4708) (min.: 14, max.: 207,894). The papers were published in 106 journals (Animals (n = 21), Scientometrics (n = 8)), classified into 56 Web of Science categories ('veterinary sciences' (n = 26 journals)). Searches related to 88 different topics. There were 517 unique keywords in the papers, among which 'bibliometric(s)' (n = 45) occurred most often. The median number of co-authors per paper was 4 (IQR: 3) (min.: 1, max.: 17), with a total of 689 individual authors. Most papers (n = 110 (67.5%)) were published under open access. The median number of citations received per paper was 4 (IQR: 9) (max.: 68) and the h-index was 21. In multivariable analysis, the higher number of cited references in papers and the inclusion of specific animal species in the record search emerged as significant for the number of citations received per paper yearly.
    Keywords:  One Health; animal science; bibliometric; bibliometric analysis; health sciences; life sciences; meta-analysis; review; scientometric; veterinary science
    DOI:  https://doi.org/10.3390/ani14213132
  17. Drug Des Devel Ther. 2024 ;18 4961-4974
       Background: Many studies have been conducted on the use of selective serotonin reuptake inhibitors (SSRIs) for the treatment of depression. However, the overall trends in research publications in this field remain elusive. There is still little quantitative analysis of the literature in this field. Therefore, we conducted a bibliometric analysis to explore the research patterns surrounding SSRIs for depression, aiming to gain a deeper understanding of their development and impact.
    Methods: Publications about the use of SSRIs for the treatment of depression were identified in the Web of Science Core Collection. Visualization analysis was performed with Bibliometrix, VOSviewer, and CiteSpace.
    Results: A total of 1149 publications published from 1990 to 2024 were included in the bibliometric analysis. Since 1990, the annual number of published papers has increased annually, reaching the maximum value of output in 2004. Fitted curve showed that after 2004, the number of publications per year was essentially stable The United States dominates the field. Among these institutions, University of Pittsburgh excels in this field. Fava M has the highest scientific productivity and extensive academic influence. European Neuropsychopharmacology is the most active journal in this field. The three most relevant keywords were "fluoxetine", "double-blind", and "major depression". The trend topics in recent years were "connectivity", "c-reactive protein", and "anhedonia".
    Conclusion: Research on the use of SSRIs for the treatment of depression continues to receive increased attention but still requiraes further exploration and innovation. We further analyze the current research hotspots and frontiers in this field.
    Keywords:  bibliometrics; depression; double-blind; fluoxetine; major depression; selective serotonin reuptake inhibitors
    DOI:  https://doi.org/10.2147/DDDT.S476680
  18. Syst Rev. 2024 Nov 13. 13(1): 279
       BACKGROUND: Fibrosis is the ultimate, common pathological ending of most chronic inflammatory diseases and increases the chances of developing life-threatening illnesses. Pyroptosis, a newfound form of lytic programmed cell death initiated by the inflammasome, has received more and more attention because of its association with fibrotic diseases. Therefore, this study visualizes the connection between pyroptosis and fibrosis research through bibliometric methods, aimed at providing global research hits and tendencies in the field.
    METHODS: We collected and analyzed the articles on pyroptosis and fibrosis from 2010 to 2024 via Web of Science. Visual data analysis was performed for countries, institutions, authors, references, and keywords in the field using VOSviewer, CiteSpace software, the "Bibliometrix" R package, the bibliometric website ( https://bibliometric.com/ ), and Excel software. We analyzed the data by utilizing the bibliometric review method.
    RESULTS: A total of 566 articles and reviews relating to pyroptosis and fibrosis were identified in the Web of Science. The number of publications in the domain has continued to grow since 2010. These scientific outputs were mainly from 129 countries/regions and 1919 institutions, particularly China (n = 423) and the USA (n = 83). More importantly, although China publishes a vast majority of articles, its centrality is lower than that of the USA (0.59 vs 0.61). Among the 3833 authors involved in this field, Feldstein, A. E. is the most prolific author. Shi, J. J. is the world's most-cited author among the 12,143 authors in these academic journals. Frontiers in Immunology was a prolific contributor, and Nature was the most frequently cited journal. After analysis, Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death were the top-cited articles. The analysis of keywords displayed that pyroptosis, fibrosis, and pathways were the main research hotspots and frontier directions in recent years.
    CONCLUSION: We analyzed the characteristics of published articles and drew a fundamental knowledge structure on pyroptosis and fibrosis research via bibliometric analysis. The potential mechanism between fibrosis and pyroptosis is deeply tied to the current moment. Our findings can help researchers make clear the research status and value of fibrosis and pyroptosis and provide new directions for future research as soon as possible.
    DOI:  https://doi.org/10.1186/s13643-024-02703-0
  19. Front Aging Neurosci. 2024 ;16 1456824
       Objective: The diagnosis and treatment of biomarkers in Alzheimer's disease has emerged as a prominent topic within Alzheimer's disease research. In this paper, we conducted a bibliometric analysis of data from a wide range of literature in this field to enhance the in-depth understanding of this area.
    Method: The core collection of the Science Citation Index database (web of science) was used to search for relevant literature in the above fields from 1 January 2006 to 14 November 2022 and Citespace software was used to visualize and analyze the literature data.
    Results: A total of 1,138 papers were included, of which the United States ranked first with 607 papers and China ranked 6th in the world with 84 papers. The value of mediational centrality is 0.49 in the United States and 0.05 in China. In terms of the number of articles published by the research authors, the Swedish scholar Blennow Kaj ranks first with 82 articles published, and the scholars who rank second and third are Zetterberg Henrik (78 articles) and Morris John C (64 articles), respectively; in terms of the mediational centrality, the American scholar Trojanowski John Q ranked first in the world with 0.1, and the second and third ranked scholars were Blennow Kaj (0.09) and Zetterberg Henrik (0.06) respectively. Scholar JACK CR ranked first with 377 citation frequency. The journal NEUROLOGY is ranked first with 943 citations.
    Conclusion: In recent years, global research in the field of biomarkers related to Alzheimer's disease has shown signs of softening, and the momentum of research has slightly diminished. However, this trend does not imply a decline in the quality of research. It is essential to enhance collaboration among countries, major research institutions, and scholars, with a particular emphasis on fostering international partnerships in the future.
    Keywords:  Alzheimer’s disease; bibliometrics; biomarkers; growing trend; research status; visual analysis
    DOI:  https://doi.org/10.3389/fnagi.2024.1456824
  20. Aesthetic Plast Surg. 2024 Nov 14.
       BACKGROUND: Significant advancements have been made in the field of clinically relevant fat research over the past decade. A systematic analysis of publications in this domain is essential. This study aims to identify research hotspots and evolving trends in clinically relevant adipose tissue research through bibliometric analysis.
    METHODS: Publications related to fat clinical research from 2014 to 2023 were extracted and analyzed from the Web of Science (WOS) Core Collection database. The data from this 10-year period were divided into two 5-year intervals (2014-2018 and 2019-2023) for analysis. Various aspects such as author keywords, countries, institutions, authors, and journal co-occurrence were studied. The data were analyzed and visualized using VOSviewer.
    RESULTS: After selecting the retrieval strategy, a total of 892 publications were extracted for the period 2014-2018 and 1622 publications for 2019-2023. Comparing the two intervals, the United States was the country with the highest number of publications (354 publications vs. 546 publications). The institution with the highest output was Peking Union Medical College (26 publications vs. 87 publications). The most prolific author was Klinger M (4 publications) vs. Hua Zuguang (18 publications). The most active journal was Plastic and Reconstructive Surgery (178 publications) vs. Aesthetic Surgery Journal (244 publications). The most active research areas were focused on "fat grafting," "liposuction," and "body contouring," with a rapid increase in research related to "facial rejuvenation" using fat grafting, suggesting it may be the next research hotspot.
    CONCLUSION: Clinical research related to fat is rapidly evolving. This study provides a visual network and trend analysis of fat research over the past decade.
    LEVEL OF EVIDENCE III: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine Ratings, please refer to Table of Contents or online Instructions to Authors www.springer.com/00266 .
    Keywords:  Bibliometric analysis; Body contouring; Facial rejuvenation; Fat filling; Fat grafting; Liposuction
    DOI:  https://doi.org/10.1007/s00266-024-04510-3
  21. Exp Cell Res. 2024 Nov 13. pii: S0014-4827(24)00409-9. [Epub ahead of print] 114318
      Extrachromosomal circular DNA (eccDNA),a type of circular DNA that has a nucleosomal structure, is widely distributed in eukaryotic chromosomes and has been found to modulate genome instability and plasticity, playing a role in regulating gene expression and genome evolution. To comprehensively outline the stages of eccDNA research development, including author collaborations, research topics and hotspots, and their temporal evolution trends, we conducted a bibliometric analysis of 242 publications related to eccDNA research published from 2008-2023 in the Web of Science Core Collection. The bibliometric analysis was performed using CiteSpace, the R package Bibliometrix, and VOSviewer. The USA, the University of California system, and Turner Km were found to be the most influential nation, organization, and author in this field, respectively. The exploration of Characterization and Diagnosis, Heterochromatin,Circ-Seq and Cancer Drug Resistance on eccDNA are the most concerned hotspots. EccDNA research has become a rapidly growing hotspot, receiving extensive attention from scholars in recent years. This study is the first to investigate the development and current challenges of eccDNA research through bibliometric analysis.The research on eccDNA has advanced from disorder to more intricate molecular functions. At present, the rapid growth of eccDNA studies in cancer has not been accompanied by an intuitive analysis of its evolutionary patterns. This review provides an overview of eccDNA's biological characteristics and functions, with a focus on its role in cancer research.
    Keywords:  Bibliometrics analysis; Biogenesis; Molecular marker; Research hotspots; eccDNA
    DOI:  https://doi.org/10.1016/j.yexcr.2024.114318
  22. Front Psychiatry. 2024 ;15 1468568
       Objective: Sleep disorder is a common non-motor symptom (NMS) of Parkinson's disease. However, the global research focus on Parkinson's sleep-related disorders (PDSDs) and future trends remains unclear. Currently, there is no bibliometric analysis of PDSDs. We aim to fill this gap, determine the status of current research, and predict future research hotspots.
    Methods: We selected 1490 publications from the Web of Science Core Collection (WoSCC) database from 2008 to 2023. Based on CiteSpace and VOSviewer, the analysis was performed from the perspectives of the trend in the number of annual publications, countries, institutions, authors, journals, and co-citations.
    Results: A total of 1490 publications from 590 authors from 409 institutions in 77 countries are included. The United States, China, and the United Kingdom are the leading countries. University College London (UCL) is the most prolific institution. Harvard University is the key for cooperation among institutions. Chaudhuri Kallol Ray is a leader in this field. "Movement Disorders" is the most influential journal. "A systematic review of the literature on disorders of sleep and wakefulness in Parkinson's disease from 2005 to 2015" is the publication with the highest co-citation intensity.
    Conclusion: The total volume of publications on PDSDs is on the rise, entering a relatively high-yield stage in 2020. The COVID-19 pandemic and the emergence of new keywords may be the reasons behind this phenomenon. "quality of life" and "circadian rhythm" are the mainstream topics of PDSD research. Daytime sleepiness is the PDSD subtype that has received the most attention. Sleep quality, biomarkers, and neurodegeneration are likely to become future research hotspots.
    Keywords:  CiteSpace; Parkinson’s disease; VOSviewer; bibliometrics; sleep disorders; visual analysis
    DOI:  https://doi.org/10.3389/fpsyt.2024.1468568
  23. Front Cell Dev Biol. 2024 ;12 1412363
       Introduction: Our study aims to provide a comprehensive overview of mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) in drug delivery research, focusing on the period between 2013 and 2023. Given the increasing global interest in this field, we utilized bibliometric tools to explore publication trends, key contributors, and thematic research clusters.
    Methods: Data was collected from the Web of Science (WoS) database, and an in-depth bibliometric analysis was conducted using VOSviewer. The analysis encompassed bibliographic coupling, co-citation, co-authorship, and co-occurrence trends, offering a structured insight into global research activity. We also employed Citespace to further analyze thematic clusters in this domain.
    Results: Our analysis revealed a total of 1,045 publications related to MSC-EVs in drug delivery over the past decade, showing a steady increase in research output. China led in publication count, H-index, prolific authors, and research funding, while the United States ranked highest in total citations, average citation counts, and H-index performance. Pharmaceutics emerged as the leading journal by publication volume, with the Journal of Controlled Release having the strongest total link strength. Top institutions driving research included Shanghai Jiao Tong University, Zhejiang University, and Harvard University. VOSviewer analysis identified four major research clusters: tissue engineering, cancer, neurological diseases, and targeted delivery. Citespace analysis refined this further into ten thematic areas, including differentiation, tissue regeneration, and drug resistance.
    Discussion: This bibliometric assessment provides a holistic visualization of the research landscape for MSC-EVs in drug delivery, underlining the significant contributions of China and the United States. Our findings underscore the increasing global importance of MSC-EV research and highlight emerging themes that will likely guide future research directions. The insights from this study offer a foundational framework for identifying nascent frontiers in MSC-EV-based drug delivery.
    Keywords:  bibliometric; extracellular vesicles; mesenchymal stem cell; research hotspots and trends; visualization
    DOI:  https://doi.org/10.3389/fcell.2024.1412363
  24. J Pediatr Nurs. 2024 Nov 07. pii: S0882-5963(24)00398-1. [Epub ahead of print]
       OBJECTIVE: This study aims to reveal the general, social, and intellectual structure of breastfeeding studies published in the field of nursing between 2014 and 2023 by using the bibliometric method.
    METHODS: A total of 2304 articles published in the last ten years were reached by searching the Web of Science database using the keywords "breastfeeding" and "breast feeding." Study data were analyzed on the open source R Studio software and the "biblioshiny for bibliometrix" package, an R software tool. Descriptive, cluster, and network analyses were performed.
    RESULTS: Of the articles, 10.46 % were single-author studies, the mean collaboration index was three, and the author footprint index was 0.22. The most cited article in the intellectual field had been published by Henshaw et al. in 2014. The word tree mapping yielded four basic concepts as a result of the evaluation of the word frequencies. The theme analysis indicated that advanced hotspots and the main topics discussed by the authors mainly included breastfeeding, lactation, breastfeeding support, and exclusive breastfeeding. The United States was the country with the highest number of publications and was effective in collaboration.
    CONCLUSIONS: Breastfeeding studies in the field of nursing conducted in the last decade maintain their importance in the field.
    PRACTICAL IMPLICATIONS: Breastfeeding continues to be important in the field of nursing as well as maternal and infant health. The results of the study are expected to guide researchers, policy makers and program managers interested in the subject.
    Keywords:  Bibliometrics; Breastfeeding; Human milk; Nursing
    DOI:  https://doi.org/10.1016/j.pedn.2024.10.036
  25. J Craniofac Surg. 2024 Nov 11.
      Lymph node metastasis (LNM) is a significant prognostic factor in head and neck cancer (HNC) patients. To obtain a better understanding of the worldwide prevalence and current research status, the authors conducted a comprehensive bibliometric analysis of literature published from 2000 to 2022. The contributions of institutions, journals, countries or regions, cited literature, keywords, and authors in global publications were concisely summarized using the COOC and VosViewer software tools. The data were extracted from the expansive Web of Science database. A total of 5478 papers were collected for analysis, and the number of publications has exhibited exponential growth over the last 22 years. The United States emerged as the most productive country, closely followed by China. Noteworthy institutions for their high productivity include the Sloan-Kettering Cancer Center, Sun Yat-Sen University, and the University of Texas MD Anderson Cancer Center. The Head & Neck and Oral Oncology journals lead in terms of publication volume. The main areas of research in this field were prognostication, radiotherapy, survival rates, sentinel lymph node biopsy, and the human papillomavirus. In addition, the analysis of author collaboration networks yielded valuable insights into the collaborative relationships within this research domain. Our research has identified the primary characteristics of highly impactful studies on LNM in HNC, providing significant insights into the advancements made in this area of research.
    DOI:  https://doi.org/10.1097/SCS.0000000000010873
  26. Medicine (Baltimore). 2024 Nov 08. 103(45): e40437
      Surface ablation laser surgery has resurged in popularity recently because of its safety in correcting myopia and favorable postoperative corneal biomechanical properties. This study aimed to investigate the current focal points and future trends in surface ablation laser surgery over the last 2 decades. The Web of Science Core Collection was used as the primary data source to retrieve literature related to surface ablation laser surgery. All records, including full records and reference details, were exported in plain text format. VOSvivewer, CiteSpace, and Pajek were used to perform the bibliometric and visual analyses of the countries/regions, institutions, authors, journals, and keywords of relevant publications. A total of 3415 articles on surface ablation laser surgery were published in 253 journals. These articles were authored by 9681 individuals from 2751 institutions across 79 countries. The United States leads in terms of productivity and influence in this field. The Tehran University of Medical Sciences and Kymion GD were the most productive institutions and authors, whereas the University of Crete and Randleman JB were the most influential. The Journal of Cataract and Refractive Surgery was the most productive and influential in this area, and citation analysis revealed that the top 10 most-cited references focused primarily on postoperative wound healing and wavefront aberration. The keywords were grouped into the following 5 clusters: clinical effects and complications, special indications, iatrogenic corneal ectasia, haze, and pain management. High-frequency keywords in recent years included transepithelial photorefractive keratectomy, retreatment, transepithelial phototherapeutic keratectomy, and biomechanical properties. This bibliometric analysis examined the development trends, global cooperation, research hotspots, and future directions of surface ablation over the past 20 years.
    DOI:  https://doi.org/10.1097/MD.0000000000040437
  27. Front Med (Lausanne). 2024 ;11 1395641
       Background: Peripartum respiratory complications are a major reason for pregnant women's admission to the ICU, even endangers the maternal life. This bibliometric analysis was designed to elucidate the spectrum of diseases and risk factors for various respiratory complications during the peripartum period, as well as the future research directions in this field.
    Methods: Relevant publications were downloaded from the Web of Science Core Collection on November 1, 2023. CiteSpace was utilized for conducting the scientometric study.
    Results: A total of 2,331 articles and reviews on respiratory complications during pregnancy published between 2004 and 2023 were retrieved, comprising 87,244 co-cited references, originating from 568 institutions across 104 countries/regions. The United States emerged as the leading country in this domain, with Harvard University standing out as the most actively engaged institution. Bibliometric analysis reveals that the current research hotspots include "COVID-19 pandemic," "venous thromboembolism," "respiratory distress syndrome" and "cardiovascular diseases." Meanwhile, "venous thromboembolism," cytokine storm" and supportive management such as "extracorporeal membrane oxygenation" might represent potential future research directions.
    Conclusion: Over the past two decades, research on respiratory system complications in pregnancy has continually evolved. This study contributes to enabling researchers in the related field to understand future research hotspots and trends, providing information on potential collaborators, institutions, countries, and citation references.
    Keywords:  CiteSpace; bibliometrics; peripartum respiratory complications; risk factors; visualization analysis
    DOI:  https://doi.org/10.3389/fmed.2024.1395641
  28. Front Psychol. 2024 ;15 1457625
      Depression is a common psychological complication in osteoarthritis (OA) patients, and its incidence gets more and more attention year by year worldwide. This study investigates the association between OA and depression through a bibliometric analysis of published studies. It aims to identify leading authors, institutions, and countries to highlight research hotspots and suggest potential future directions. We collected publications on OA and depression from 1994 to 2024 using the Web of Science Core Collection (WOSCC) database. Bibliographic information, including authorship, country of origin, citation frequency, and visualizations, was generated using VOSviewer, R software, and CiteSpace. A total of 2,342 articles were identified. The United States led in publications with 906 articles, Boston University was the most prolific institution with 56 publications, BMC Musculoskeletal Disorders was the top journal with 71 publications, and Stefania Maggi was the most productive author with 19 publications. The primary research hotspots identified were: "The relationship between depression and OA," "Disability and prevalence," and "Characteristics of older people suffering depression after OA." Predicted future research frontiers include: "Treating depression in OA patients with multimorbidity," "Psychometric properties of instruments for assessing depression and anxiety in OA patients," "Depression or anxiety in patients with surgical intervention," and "Other mental diseases in OA patients." This bibliometric analysis underscores the importance of understanding the link between OA and depressive disorders, potentially guiding new research directions.
    Keywords:  CiteSpace; bibliometric analysis; depression; evolving trends; osteoarthritis
    DOI:  https://doi.org/10.3389/fpsyg.2024.1457625
  29. Brain Circ. 2024 Jul-Sep;10(3):10(3): 229-239
       BACKGROUND AND AIMS: Neuroprotection plays an important role in the treatment of brain disorders. In recent years, studies using rat models and clinical trials have demonstrated the positive effects of hydrogen treatment on neurological disorders and brain injuries. Hence, it is of great significance to shed light on this issue. In this article, CiteSpace is employed for visualization and bibliometric analysis of the research frontiers and evolving trends related to the neuroprotective effect of hydrogen.
    METHODS: All articles published from 2009 to 2023 that discussed the neuroprotective effects of hydrogen in cerebrovascular diseases were retrieved from the Web of Science. Using CiteSpace, a visualization analysis was conducted on aspects such as countries, institutions, authors, keywords, and Co cited references, which enables an intuitive observation of current research hotspots.
    RESULTS: After manual screening, a total of 106 articles were retrieved. Over time, The number of publications has increased annually. Regarding national contributions, the top three countries with the highest number of publications include China, the United States, and Japan. The Second Military Medical University is the institution that publishes the most articles and has significant influence in the field of hydrogen neuroprotection. Sun, Xuejun and Domoki, Ferenc were the most productive. The most common keywords include hydrogen, oxidative stress, inflammation, and apoptosis. Potential areas of focus for future research consist of early brain injury, hydrogen, ischemia-reperfusion injury and hypothermia treatment.
    CONCLUSION: The bibliometric study presented herein offers insights into the current status and trends of research on hydrogen in the field of cerebrovascular diseases. Future research trends suggest that hydrogen contributes significantly to the cerebrovascular domain through its anti-inflammatory, antioxidative, and anti-apoptotic mechanisms. This study can aid researchers in identifying hot topics and exploring new research directions.
    Keywords:  Apoptosis; CiteSpace; hydrogen; hypothermia treatment; inflammation; neurological diseases; neuroprotection; oxidative stress
    DOI:  https://doi.org/10.4103/bc.bc_111_23
  30. Medicine (Baltimore). 2024 Nov 08. 103(45): e40403
      Chondrosarcoma is 1 of the most common malignant bone tumors, with dedicated research being conducted by scientists worldwide. The purpose of this study was to guide researchers in identifying valuable scholars, institutions, and countries, provide recommendations for journal submissions, and explore research trends and hotspots in chondrosarcoma studies through literature analysis. Data for this study were collected from the Web of Science Core Collection website. The R package bibliometrix was utilized for citation metrics analysis, VOSviewer for network analysis, and CiteSpace for generating keywords citation burst maps. The analysis focused on publications from 2000 to 2023, identifying trends, authorship patterns, and collaboration networks. A total of 2085 articles were initially identified, but after excluding non-English articles and those outside the study's time range, 2022 articles were included. The field comprised 9954 author records, with an average of 6.37 coauthors per document and 13.9% international co-authorships. Publications in chondrosarcoma research have shown an average annual growth rate of 3.9%. The most influential author identified was Tang Chih-Hsin from China Medical University. Significant contributions came from China Medical University and Leiden University, with China showing a dramatic increase in publications while the United States maintained a leading position in the field. The study highlights an increasing trend in chondrosarcoma research publications and identifies key contributors and institutions. Cancer emerged as 1 of the most influential journals in the field. Future research is likely to focus on targeted therapy for refractory chondrosarcomas, indicating a potential new hotspot in the ongoing efforts to understand and treat this malignancy.
    DOI:  https://doi.org/10.1097/MD.0000000000040403
  31. Medicine (Baltimore). 2024 Nov 08. 103(45): e40297
       BACKGROUND: Congenital adrenal hyperplasia (CAH) is increasingly prevalent, leading to a surge in related research. To pinpoint emerging trends and recommend future directions, a bibliometric analysis of relevant CAH literature was performed.
    METHODS: From January 1, 2000, to October 1, 2023, we searched the Web of Science Core Collection for CAH literature. For the bibliometric analysis, tools such as VOSviewer, CiteSpace, and the R package "bibliometrix" were employed.
    RESULTS: The United States and England are at the forefront among 113 countries, contributing 5034 papers to CAH research. However, there is a need for more extensive global collaboration across institutions in this field. The number of publications on CAH is increasing annually. Leading research institutions include the University of Michigan, University of California, San Francisco, Karolinska Institutet, and Karolinska University Hospital. The Journal of Clinical Endocrinology & Metabolism is the most cited in this area. The most prolific author is Falhammar H, with 88 publications, 2568 co-citations, and a significant overall contribution. Key research areas include diagnostic methods and therapeutic strategies for CAH. Emerging research hotspots are identified by keywords such as "disorders of sex development," "21-hydroxylase deficiency," "ambiguous genitalia," "testosterone" and "adrenal insufficiency."
    CONCLUSIONS: Research on CAH is expected to expand globally. Future studies will primarily focus on exploring CAH's diagnostic aspects and developing new therapies. This paper will help scholars better understand the dynamic evolution of the CAH and point out the direction for future research.
    DOI:  https://doi.org/10.1097/MD.0000000000040297
  32. Heliyon. 2024 Oct 30. 10(20): e38762
       Objective: This study determined the development trends, analyzed collaboration networks, and identified research hotspots in the field of wearable sensors for wound care from 2007 to 2024 using a rigorous bibliometric analysis approach.
    Methods: Bibliometric and scientometric analyses were performed utilizing data sourced from the Web of Science Core Collection database. This study examined publication trends, contributions from various countries and institutions, author productivity, keyword prevalence, and citation patterns to discern research hotspots and potential future avenues in the application of wearable sensors for wound care.
    Results: This study included 1177 articles, which demonstrated a marked increase in publications since 2016 and underscores the burgeoning interest in wearable sensors for wound care. China and the United States have emerged as prominent contributors to the research field, exhibiting numerous international collaborations. An analysis of keywords and citation bursts highlighted wound healing, hydrogels, and sensors as the key research foci with recent trends shifting towards the integration of wearable technology with advanced materials and artificial intelligence for advanced wound management. The research landscape is characterized by a diverse network of international collaborations and an emphasis on interdisciplinary approaches that integrate materials science, sensor technology, and clinical applications.
    Conclusion: The utilization of wearable sensors in wound care constitutes a rapidly progressing area of research, garnering significant interest and promising avenues for future advances. The integration of wearable sensors with advanced materials and AI technologies presents a frontier of opportunity for innovating wound care methodologies, enhancing patient outcomes, and optimizing the allocation of healthcare resources.
    Keywords:  Bibliometrics analysis; Biomaterials; Sensor; Wearable sensor; Wound care
    DOI:  https://doi.org/10.1016/j.heliyon.2024.e38762
  33. Asian J Surg. 2024 Nov 15. pii: S1015-9584(24)02509-0. [Epub ahead of print]
      
    Keywords:  Bibliometric analysis; Cardiovascular diseases; Immunotherapy
    DOI:  https://doi.org/10.1016/j.asjsur.2024.10.176
  34. Front Psychiatry. 2024 ;15 1338455
       Background: Limitations of conventional treatment methods for sleep disorders have driven the use and development of complementary and alternative therapies such as acupuncture. However, despite the surge in related studies, there is still a lack of visual analysis and detailed elaboration regarding the current status, international collaborations, and research hotspots of acupuncture for sleep disorders.
    Methods: We conducted a bibliometric analysis of publications on acupuncture for sleep disorders using the Web of Science Core Collection database from 2004 to 2023. We utilized the R package "bibliometrix" to count publications and citations, VOSviewer to create an inter-institutional referencing network, and CiteSpace to identify references and keywords with the highest citation bursts. Additionally, we employed a bibliometric online analysis platform designed for analyzing national partnerships.
    Results: A total of 432 pertinent papers were retrieved, with China being the most prolific contributor, accounting for 61.6% of the publications, followed by the United States and South Korea. Despite China's high output, its average article citation rate and proportion of international collaborations were notably lower than those of the United States. Key research institutions such as the University of Hong Kong, Shanghai University of Traditional Chinese Medicine, Memorial Sloan Kettering Cancer Center, and Guangzhou University of Chinese Medicine have played significant roles in this field. Among authors, Ka-Fai Chung from the University of Hong Kong stood out as the most productive. In terms of journals, MEDICINE was the most active, while SLEEP was considered the most authoritative. The clinical effects of acupuncture for insomnia have garnered significant attention in recent years, with electroacupuncture emerging as the prevailing technique for addressing sleep disorders.
    Conclusion: This bibliometric study effectively outlines the basic framework of knowledge surrounding acupuncture for sleep disorders over the past two decades, covering publications, countries, institutions, authors, and sources. It highlights promising clinical effects and underlying mechanisms of acupuncture, particularly for secondary insomnia and specific sleep disorders like restless legs syndrome. Moving forward, the focus and challenge for future research lie in the development of standardized study protocols and harmonization of efficacy assessment metrics.
    Keywords:  acupuncture; bibliometrics; electroacupuncture; insomnia; sleep disorders; visualization
    DOI:  https://doi.org/10.3389/fpsyt.2024.1338455
  35. Dermatol Surg. 2024 Nov 12.
       BACKGROUND: Solid organ transplant recipients are at high risk for developing skin malignancies due to prolonged immunosuppression. The field of transplant dermatology (TD) has experienced a surge in research and clinical advancements, yet there is no quantitative evaluation estimating the impact of TD literature.
    OBJECTIVE: Identify and characterize the most frequently cited TD articles.
    METHODS: Institute For Scientific Information Web of Science was used to identify the 50 most cited research articles in TD. Results were reviewed by 3 independent authors. A network analysis was performed to assess collaboration patterns among coauthors.
    RESULTS: Top articles held a combined total of 12,114 citations. The top-cited article was "Cancer incidence before and after kidney transplantation," by Vajdic and colleagues in the Journal of the American Medical Association (2006) with 872 citations. A total of 22 countries and 221 institutions were represented.
    CONCLUSION: This bibliometric analysis offers a detailed overview of the most cited manuscripts in TD and illustrates the discoveries steering TD research and practice.
    DOI:  https://doi.org/10.1097/DSS.0000000000004486
  36. RSC Adv. 2024 Nov 04. 14(48): 36040-36062
      Green diesel as a second-generation biofuel has received enormous attention owing to the huge demand for renewable fuel for addressing the net zero target in 2050. This study examines the development of green diesel research through a bibliometric analysis. The state-of-the-art green diesel research is studied based upon 1285 documents (1153 articles and 132 reviews) retrieved from the Scopus database related to the used keywords. The analysis focused on three categories: publication outcomes, most cited papers, and research area identification. The VOSviewer and RStudio (bibliometrix) were applied to analyse the data, rationalized within the framework of author, affiliation, country, citation analysis, cross-dimensional keyword analysis, research streams, and research gaps. The general result of the study highlighted a continuous incline in article numbers classified into three stages: initiation, exploration, and elevation. Those articles were mainly published in bioenergy-themed journals, including Fuel, Energy & Fuels, and Renewable and Sustainable Energy Reviews. Taufiq-Yap Yun Hin is the highest contributor with 41 articles, and Fuel published 110 articles. The rapid growth of green diesel was also inferred by the extensive spread of research maps worldwide. Amid those swift developments, the state of the art on green diesel through bibliometric analysis is not available to the best of our knowledge as far. Subsequently, this review aims to display the state of the art, research gap, and future forecast of green diesel research.
    DOI:  https://doi.org/10.1039/d4ra06262k
  37. Asian J Surg. 2024 Nov 11. pii: S1015-9584(24)02498-9. [Epub ahead of print]
      
    Keywords:  Alzheimer's disease; Apitherapy; Bibliometric analysis; Mechanism
    DOI:  https://doi.org/10.1016/j.asjsur.2024.10.165
  38. J Intellect Disabil. 2024 Nov 13. 17446295241299160
      Down syndrome (DS), characterised by compromised brain development and intellectual challenges, often manifests Alzheimer's disease (AD) -like symptoms. Utilising the Web of Science Core Collection (WOSCC) database from January 1, 2000, to July 31, 2023, we conducted a comprehensive bibliometric analysis using VOSviewer, CiteSpace, and the R package "bibliometrix." Analyses included co-authorship, co-citation, co-occurrence, cooperative network, reference, and keyword burst citation. Analysing 5,082 papers, the U.S. demonstrated prominence with the highest number of research organisations and citations. Keyword analysis revealed promising research areas, including "Alzheimer's disease," "development," "inflammation," and "neurogenesis". This 22-year survey of the brain with trisomy 21 research unveils key trends, contributors, and focal areas in DS neuropathogenesis. Notably, Alzheimer 's-related genes and proteins play a pervasive role in DS neuropathological processes across patients' lifespans. The study contributes foundational knowledge for advancing research and care in the DS neuropathogenesis domain.
    Keywords:  Alzheimer's; Down syndrome; neurogenesis; neuropathogenesis; reactive astrocyte
    DOI:  https://doi.org/10.1177/17446295241299160
  39. Asian J Surg. 2024 Nov 06. pii: S1015-9584(24)02407-2. [Epub ahead of print]
      
    Keywords:  Bibliometric analysis; Diabetic peripheral neuropathy; Emotional distress
    DOI:  https://doi.org/10.1016/j.asjsur.2024.10.097
  40. Front Neurol. 2024 ;15 1430138
       Background: Migraine is a widespread, recurrent primary headache disorder primarily characterized by severe pulsatile headache, typically on one or both sides. It is often accompanied by nausea, vomiting, and hypersensitivity to sound and light. Despite the availability of multiple drugs for migraine management, the condition often becomes chronic due to untimely or irrational drug use, significantly distressing patients and increasing the burden on families and society. Over the past two decades, numerous clinical studies on migraine have been published. This study aimed to provide a comprehensive summary of the current status and trends of migraine clinical trials through bibliometric analysis.
    Methods: We used visual network tools such as CiteSpace and VOSviewer to perform a knowledge graph analysis of publications related to migraine clinical trials extracted from the WoSCC.
    Results: This study analyzed 1,129 articles published in 389 journals from 61 countries. The number of publications on migraine clinical trials has steadily increased from 2004 to 2023. The United States and Albert Einstein College of Medicine are the leading countries and institutions in this field, respectively. Richard B. Lipton is the most prolific author, making significant contributions to the research. The journal Headache has the highest number of publications and citations in this area. Keywords such as "efficacy," "RCT," "CGRP," "prophylaxis," "disability," "depression," "questionnaire," and "real-world effectiveness" received significant attention.
    Conclusion: This study identified reliable research hotspots and provided directions for clinicians. The treatment of migraine continues to be challenging. Future trends may include continued growth in migraine classification, risk factor analysis, and comorbidity studies. Research on CGRP and epigenetics will advance the progress of precision medicine in the migraine field.
    Keywords:  CGRP; CiteSpace; VOSviewer; bibliometric analysis; clinical trials; migraine; precision medicine
    DOI:  https://doi.org/10.3389/fneur.2024.1430138
  41. Ann Med Surg (Lond). 2024 Nov;86(11): 6602-6618
       Background: In recent years, glucagon-like peptide-1 (GLP-1) agonists have garnered increasing attention for their potential cardiovascular benefits beyond glycemic control in patients with diabetes. Understanding the research landscape surrounding GLP-1 agonists and cardiovascular diseases (CVDs) is crucial for informing clinical practice and guiding future research endeavors. This bibliometric analysis aimed to comprehensively assess the scholarly output and trends in this field, shedding light on the evolving landscape of GLP-1 agonists' role in cardiovascular health.
    Methods: The publications concerning GLP-1 agonists in CVDs were gathered from the Web of Science Core Collection, and visualizations were created utilizing Excel 2019, Cite Space, and VOS viewer software.
    Results and Conclusion: Using bibliometric and visual methods, the research hotspots and trends regarding GLP-1 agonists in cardiovascular diseases were pinpointed. Additionally, a thriving interest in GLP-1 agonists research within cardiovascular medicine was observed, with a notable surge in publications from 2016 onwards. The analysis revealed that the United States and China are the leading contributors, accounting for over 50% of the total publications. The University of Copenhagen and the University of Toronto emerged as the most prolific institutions in this field. Co-citation analysis highlighted the influential role of landmark clinical trials, such as the LEADER, ELIXA, and EXSCEL. Keyword trend analysis identified the emergence of newer GLP-1 agonists, such as tirzepatide and semaglutide, as well as a growing focus on topics like 'healthy obesity' and chronic kidney disease. These findings suggest that the research landscape is evolving, with a focus on expanding the therapeutic applications of GLP-1 agonists beyond glycemic control. Overall, this bibliometric analysis provided insights into the current state and future directions of research on GLP-1 agonists and their impact on cardiovascular health, guiding future research endeavors, and informing clinical practice.
    Keywords:  bibliometric analysis; cardiovascular diseases; diabetes mellitus; glucagon-like peptide-1; trend
    DOI:  https://doi.org/10.1097/MS9.0000000000002592
  42. Pain Manag Nurs. 2024 Nov 07. pii: S1524-9042(24)00268-6. [Epub ahead of print]
       PURPOSE: The aim of the study was to examine the hotspots and global trends of massage in nursing research.
    METHODS: Based on 241 articles published between 1993 and 2023 obtained from the Web of Science database, methods such as trend analysis and keyword frequency analysis were employed to analyze the evolution of research over time and identify key topics. Additionally, topic clustering of abstracts was conducted to examine thematic areas and connections within massage research.
    RESULTS: The analysis shows that the use of massage is prominent in specific fields such as oncology, pediatrics, gynecology, and obstetrics. An analysis of the most cited articles revealed that topics such as the effects of massage on cancer pain and anxiety and the use of complementary therapies in newborns were important. It was determined that the leading authors of massage research generally work in the fields of "massage," "nursing," "pain," "aromatherapy," "anxiety" and "complementary therapies." Collaboration between authors and countries, which is important in terms of global knowledge sharing, is almost nonexistent.
    CONCLUSIONS: The results of the study show that massage research is particularly prominent in certain medical fields such as cancer and that studies on the effects of massage in these fields are important. Furthermore, the fact that the leading authors of massage research are often specialized in specific fields and that there is limited collaboration between authors plays an important role in determining the future directions of massage research and highlights the need to encourage interdisciplinary collaboration.
    Keywords:  Bibliometric analysis; Data visualization; Massage; Nursing; Oncology; Pain
    DOI:  https://doi.org/10.1016/j.pmn.2024.10.003
  43. Front Pharmacol. 2024 ;15 1437760
       Background: Cardiovascular diseases (CVD) pose a significant threat to human health due to their high mortality and morbidity rates. Despite advances in treatments, the prevalence and impact of cardiovascular disease continue to increase. Sodium-glucose transporter 2 inhibitors (SGLT2i), initially approved for the treatment of type 2 diabetes, have important research value and promising applications in reducing CVD risk, especially in heart failure (HF) and atherosclerosis patients with cardiovascular disease (ASCVD). This study aims to comprehensively review the latest progress, research trends, cutting-edge hot spots, and future development directions of SGLT2i in the field of CVD through bibliometric analysis.
    Methods: Articles related to MSCs in cardiovascular diseases were sourced from the Web of Science. The bibliometric analysis was conducted using CiteSpace and VOSviewer, and a knowledge map was created based on the data obtained from the retrieved articles.
    Results: In this article, we screened 3,476 relevant studies, including 2,293 articles and 1,183 reviews. The analysis found that the number of papers related to the application of SGLT2i in CVD has generally increased, peaking in 2022. The United States and China contributed the largest number of papers, with the United States accounting for 36.97% of the total and also ranking first in terms of the number of citations. However, China's high-quality papers are slightly lacking and need further improvement. Keyword analysis showed that empagliflozin, dapagliflozin, diabetes, and heart failure were the most common terms, reflecting the main research interests in currently published papers in this field.
    Conclusion: Bibliometric analysis showed a robust and growing interest in the application of SGLT2i for treating CVD. By summarizing the latest progress of SGLT2i in the field of CVD, exploring research hotspots, and looking forward to future research development trends, this article provides valuable insights for thinking about research prospects.
    Keywords:  Citespace; VOSviewer; bibliometric study; cardiovascular disease; sodium-glucose transporter 2 inhibitor
    DOI:  https://doi.org/10.3389/fphar.2024.1437760
  44. Asian J Surg. 2024 Nov 11. pii: S1015-9584(24)02501-6. [Epub ahead of print]
      
    Keywords:  Anesthesia; Bibliometric analysis; Ciprofol; Pharmacological research; Safety
    DOI:  https://doi.org/10.1016/j.asjsur.2024.10.168
  45. Front Immunol. 2024 ;15 1478773
       Background: Colorectal cancer (CRC) is a malignant tumor that poses a significant threat to human health due to rising incidence and mortality rates. In recent years, immune checkpoint blockade (ICB) therapy, represented by Programmed death receptor 1 (PD-1), T-lymphocyte-associated protein 4 (CTLA-4), and others, has been widely applied in CRC and has achieved encouraging results in some patients and has become a hot topic in both clinical and basic research.
    Objective: This study undertakes a comprehensive bibliometric analysis of ICB research in CRC, aiming to evaluate the current status, identify future trends, and provide scientific insights for researchers and decision-makers.
    Methods: Utilizing the Web of Science Core Collection (WoSCC), articles focusing on ICB in CRC from 2000 to 2022 were retrieved. Knowledge mapping and bibliometric analysis were conducted using tools such as CiteSpace, VOSviewer, SCImago Graphicay, and the R package bibliometrix.
    Results: 6,718 publications were analyzed from 24,846 institutions across 639 regions. Temporally, ICB research in CRC is rapidly advancing, led by the USA and China with extensive global collaborations. Sun Yat-sen University from China stands out as the institution with the highest number of publications. Professor Thierry Andre from Sorbonne University in France is identified as a prolific author in this field, engaging in extensive collaboration for clinical trials on a global scale. Publications related to this research topic were published in 1,142 academic journals, demonstrating a positive co-citation relationship. Key clustering and burst terms analysis indicate that current research on ICB in CRC has shifted from basic experiments to clinical trials and from universal healthcare to precision medicine.
    Conclusion: ICB therapies have shown substantial progress in CRC, highlighting their therapeutic potential. Research trends emphasize deeper drug mechanisms, treatment efficacy prediction, managing immune-related adverse events, and exploring novel drug delivery methods. Collaboration across borders remains crucial for further advancements.
    Keywords:  R-bibliometrix; bibliometric analysis; colorectal cancer; immune checkpoint blockade; research trends
    DOI:  https://doi.org/10.3389/fimmu.2024.1478773
  46. Cureus. 2024 Oct;16(10): e71337
      The integration of digital health technologies with innovative business models became a crucial driver in the transformation of healthcare service delivery and management worldwide. As the adoption of electronic health (eHealth) solutions grows, there is increasing scholarly interest in understanding and optimizing these models. This paper reviewed the literature on eHealth business models from 1991 to 2024 through a bibliometric analysis of 1,118 documents published across 711 sources. The analysis primarily focused on journal articles and conference papers, utilizing VOSviewer (Centre for Science and Technology Studies, Leiden University, NLD) and Biblioshiny (Bibliometrix, Naples, ITA) to explore emerging trends, influential authors, and prominent sources. The results revealed a significant rise in research output, especially post-2007, with a peak during the COVID-19 pandemic. Key emerging themes included telemedicine, digital health, and information management, with a strong emphasis on international collaborations, particularly among countries in Europe, North America, and Asia. This study provided valuable insights into the evolution of eHealth business models, highlighting the importance of international and multidisciplinary approaches in this rapidly evolving field.
    Keywords:  bibliometric analysis; biblioshiny; business; digital health; e-health; vosviewer
    DOI:  https://doi.org/10.7759/cureus.71337
  47. Heliyon. 2024 Nov 15. 10(21): e39329
       Objective: To understand the current status, research hotspots, and trends of automatic segmentation of fundus lesion images worldwide, providing a reference for subsequent related studies.
    Methods: The electronic database Web of Science Core Collection was searched for research in the field of automatic segmentation of fundus lesion images from 2007 to 2023. Visualization maps of countries, authors, institutions, journals, references, and keywords were generated and analyzed using the CiteSpace and VOSviewer software.
    Results: After deduplication, 707 publications were sorted out, showing an overall increasing trend in publication volume. The countries with the highest publication counts were China, followed by India, the USA, the UK, Spain, Pakistan, and Singapore. A high degree of collaboration was observed among authors, and they cooperated widely. The keywords included "diabetic retinopathy," "deep learning," "vessel segmentation," "retinal images," "optic disc localization," and so forth, with keyword bursts starting in 2018 for "retinal images," "machine learning," "biomedical imaging," "deep learning," "convolutional neural networks," and "transfer learning." The most prolific author was U Rajendra Acharya from the University of Southern Queensland, and the journal with the most publications was Computer Methods and Programs in Biomedicine.
    Conclusions: Compared with manual segmentation of fundus lesion images, the use of deep learning models for segmentation is more efficient and accurate, which is crucial for patients with eye diseases. Although the number of related publications globally is relatively small, a growing trend is still witnessed, with broad connections between countries and authors, mainly concentrated in East Asia and Europe. Research institutions in this field are limited, and hence, the research on diabetic retinopathy and retinal vessel segmentation should be strengthened to promote the development of this area.
    Keywords:  Automatic segmentation; CiteSpace; Frontier; Fundus lesions; Hotspots; VOSviewer; Visual analysis
    DOI:  https://doi.org/10.1016/j.heliyon.2024.e39329
  48. Front Oncol. 2024 ;14 1424100
       Objective: In 2007, entosis was proposed as a form of programmed cell death, distinct from apoptosis. This process involves a living cell (internalized cell) actively invading a neighboring live cell of the same type (host cell), forming a cell-in-cell structure. Recently, entosis has been increasingly associated with cancer, leading to significant advancements in research. Despite this progress, a comprehensive and unbiased review of the current state of entosis research is lacking. This study aims to evaluate the developments in the field of entosis over the past decade and highlight emerging research trends.
    Materials and methods: We performed a literature search for studies published since the introduction of the entosis concept, using the Web of Science Core Collection database. The bibliometric analysis was conducted using VOSviewer, CiteSpace, Microsoft Excel, and the Bibliometrix R package.
    Results: A total of 196 articles from 39 countries and 346 institutions were included. Between 2007 and 2024, research on entosis has seen rapid growth, with most publications originating from China and the United States. The United States also leads in total citations, with Memorial Sloan Kettering Cancer Center emerging as the top research institution. Sun Qiang is the most prolific author in this field, while Overholtzer M has the highest number of citations. Current Molecular Medicine has published the most articles related to entosis. Frequently occurring keywords include "entosis," "cannibalism," "autophagy," and "apoptosis." In recent years, keywords such as "phagocytosis," "drug resistance," and "human cancers" have surged, indicating a growing focus on understanding the role of entosis in tumor progression and exploring its potential as a therapeutic target for cancer treatment.
    Conclusions: This study provides the first bibliometric analysis of entosis, detailing its evolution over the last decade. It highlights critical areas of interest, including the development of inhibitors targeting entosis and their potential clinical applications. This research aims to guide future investigations and serve as a valuable resource for scholars exploring entosis in cancer biology.
    Keywords:  CiteSpace; R package “bibliometrix”; VOSviewer; cell-in-cell; entosis
    DOI:  https://doi.org/10.3389/fonc.2024.1424100
  49. World J Gastroenterol. 2024 Nov 07. 30(41): 4461-4480
       BACKGROUND: With the increasing of the global aging population, healthy aging and prevention of age-related diseases have become increasingly important. The liver, a vital organ involved in metabolism, detoxification, digestion, and immunity, holds a pivotal role in the aging process of organisms. Although extensive research on liver aging has been carried out, no bibliometric analysis has been conducted to evaluate the scientific progress in this area.
    AIM: To analyze basic knowledge, development trends, and current research frontiers in the field via bibliometric methods.
    METHODS: We conducted bibliometric analyses via a range of analytical tools including Python, the bibliometrix package in R, CiteSpace, and VOSviewer. We retrieved publication data on liver aging research from the Web of Science Core Collection Database. A scientific knowledge map was constructed to display the contributions from different authors, journals, countries, institutions, as well as patterns of co-occurrence keywords and co-cited references. Additionally, gene regulation pathways associated with liver aging were analyzed via the STRING database.
    RESULTS: We identified 4288 articles on liver aging, authored by 24034 contributors from 4092 institutions across 85 countries. Notably, the years 1991 and 2020 presented significant bursts in publication output. The United States led in terms of publications (n = 1008, 25.1%), citations (n = 55205), and international collaborations (multiple country publications = 214). Keywords such as "lipid metabolism", "fatty liver disease", "inflammation", "liver fibrosis" and "target" were prominent, highlighting the current research hotspots. Notably, the top 64 genes, each of which appeared in at least 8 articles, were involved in pathways essential for cell survival and aging, including the phosphatidylinositol 3-kinase/protein kinase B, Forkhead box O and p53 signaling pathways.
    CONCLUSION: This study highlights key areas of liver aging and offers a comprehensive overview of research trends, as well as insights into potential value for collaborative pursuits and clinical implementations.
    Keywords:  Aging; Bibliometric; CiteSpace; Gene regulation; Liver; R language; VOSviewer
    DOI:  https://doi.org/10.3748/wjg.v30.i41.4461
  50. Hum Vaccin Immunother. 2024 Dec 31. 20(1): 2427464
      This study analyzed the growth, collaboration, citation trends, and emerging topics in nanoparticle-based vaccine and adjuvant research (NVAR) from 1977 to 2023, using data from the Scopus database. The field showed a steady growth rate of 7.53% per year. Leading researchers Jaafari, M.R. and Alving, C.R. contributed significantly to the field, with 24.22% of publications and 38.92% of total citations coming from the United States. International collaboration was very strong, particularly between the US, UK, Germany, China, and France. Key research topics include nanoparticles, immunotherapy, COVID-19, and vaccines with a focus on SARS-CoV-2 and malaria. Emerging topics include vaccine adjuvants, mRNA, and neutralizing antibodies. This study emphasizes the importance of ongoing collaboration and interdisciplinary efforts to advance the field of NVAR.
    Keywords:  COVID-19; Nanoparticle-based vaccine; adjuvant research; collaboration; immunotherapy
    DOI:  https://doi.org/10.1080/21645515.2024.2427464
  51. Asian J Surg. 2024 Nov 09. pii: S1015-9584(24)02459-X. [Epub ahead of print]
      
    Keywords:  Bibliometric analysis; Osteoarthritis; Sarcopenia
    DOI:  https://doi.org/10.1016/j.asjsur.2024.10.134
  52. J Emerg Nurs. 2024 Nov 14. pii: S0099-1767(24)00290-3. [Epub ahead of print]
       INTRODUCTION: New technologies developed for triage systems can have positive effects on health care professionals. The research was conducted to identify and visualize the studies conducted between 2001 and 2024 on triage and digital triage systems in emergency departments and reveals global trends on this subject.
    METHODS: The data were obtained from the "Web of Science Core Collection" database on February 8th, 2024. Performance analysis, scientific mapping, and bibliometric analyses were performed using the VOSviewer (1.6.15) software program. Data from 236 publications were analyzed in the study.
    RESULTS: The most publications were by Alcock J (n = 3), the most publications by country were published in the USA (n = 114), Harvard University (n = 19) was the institution that published the most, the United States Department of Health Human Services (n = 25) supported publications among the funding institutions, and the most publications were published in the Emergency Medicinal Journal (n = 8).
    DISCUSSION: The results obtained from the study reveal the triage and digital triage systems used in emergency services, provide a general perspective on the subject, and guide future research on this subject.
    Keywords:  Bibliometrics; Digital triage; Electronic triage system; Emergency department; Nursing; Triage
    DOI:  https://doi.org/10.1016/j.jen.2024.10.009
  53. Asian J Surg. 2024 Nov 11. pii: S1015-9584(24)02438-2. [Epub ahead of print]
      
    Keywords:  Bibliometric analysis; Low-level laser therapy; Spinal cord injury
    DOI:  https://doi.org/10.1016/j.asjsur.2024.10.114
  54. Arthrosc Sports Med Rehabil. 2024 Oct;6(5): 100974
       Purpose: To compare the characteristics of the top-20 studies about anterior shoulder instability according to the Altmetric Attention Score (AAS) with total citation counts.
    Methods: Two separate searches were performed for articles related to anterior shoulder instability. The Altmetric search identified the top-20 articles according to AAS. A bibliometric search using Web of Science identified the top-20 most-cited articles. Altmetric criteria were applied to the bibliometric list and vice versa.
    Results: The AAS from the Altmetric list ranged from 44 to 432. The highest AAS from the bibliometric search was 70. One study appeared in both lists. Most online mentions were from X (formerly Twitter). The geographical breakdown of X mentions saw 71 countries appearing in the Altmetric search versus 21 in the bibliometric search. The total citations in the bibliometric list ranged from 91 to 358 versus 0 to 121 for the Altmetric list. The Altmetric top-20 list contained 8 studies that were Level II or higher versus 3 in the bibliometric list.
    Conclusions: The top-20 studies according to AAS or citation count are not the same. The top-20 studies by AAS are composed of studies at higher levels of evidence versus the top-20 studies when listed by citation count.
    Clinical Relevance: Electronic searches are an important way to access information in the modern world. Different search options generate results according to different parameters and may generate different results for the same query. It is important to understand these differences so that users have a better understanding of where the most clinically useful information can be found, especially regarding medical conditions.
    DOI:  https://doi.org/10.1016/j.asmr.2024.100974
  55. Front Endocrinol (Lausanne). 2024 ;15 1505505
      [This corrects the article DOI: 10.3389/fendo.2022.845776.].
    Keywords:  FNA (fine needle aspiration); bibliometric; management; thyroid cancer; thyroid nodules
    DOI:  https://doi.org/10.3389/fendo.2024.1505505
  56. Front Genet. 2024 ;15 1402140
      Animal breeding became a difficult science when numerous genes influenced economically significant features. The major source of genetic improvement is selection, and as such, the large generation intervals in these strategies lead to reduced rates of improvement. Therefore, breeding control, genetic improvement research, and selection processes are accelerated by genomic selection. This article regarding global research interest trends in genomic selection in animal breeding themes was examined using bibliometric analysis, which employed papers from 1993 to 2024 from the SCI-Expanded, SSCI, AHCI, and E-SCI indexes. Over the period of 31 years, the first 3,181 published articles on genomic selection in animal breeding were gathered. Additionally, the study displays trends in co-authorships according to nations and academic institutions as well as co-occurrences of author keywords. There have been more articles since 2010 about the use of genomic selection in animal breeding, building up a sizable library of work that will last until 2024. Among the top academics in the field are Calus MPL, Li J, and Wang Y. The most productive institutions were The United Kingdom's University of Edinburgh, Aarhus University (Denmark) and China Agricultural University. The current hotspots in this field of study include "selection," and "association," according to keyword co-occurrence and frequency analysis. China, the United States, Brazil, Canada, and United Kingdom are the top five countries that produced the most papers with the highest levels of international collaboration and networking. The main topics of current study include prediction, accuracy, association, traits, and selection. New techniques for selection, prediction, accuracy, traits, and association were developed as the discipline matured. Research collaborations across countries, institutions, and writers promote knowledge sharing, effective issue resolution, and superior outcomes.
    Keywords:  bibliometric analysis; genomic selection; literature review; research on evaluation; trend
    DOI:  https://doi.org/10.3389/fgene.2024.1402140
  57. Int J Biochem Cell Biol. 2024 Nov 08. pii: S1357-2725(24)00180-8. [Epub ahead of print]177 106687
       BACKGROUND: Radiotherapy serves as a crucial modality in cancer treatment, frequently synergizing with other therapies to enhance patient outcomes. Unfortunately, radiotherapy is often accompanied by nutritional impairments, including dysphagia and malnutrition, which hinder patient recovery and treatment efficacy. Moreover, nutritional abnormalities accompanied by metabolic reprogramming may lead to alterations across multiple omics domains. Consequently, big data analysis on radiotherapy and nutrition is imperative.
    OBJECTIVE: This study employs bibliometric analysis to visually showcase the current research landscape and trending hotspots in the intersection of nutrition and radiotherapy.
    METHODS: Leveraging the Web of Science Core Collection, we screened and analyzed 4379 publications related to nutrition and radiotherapy published between 2004 and 2023. Utilizing VOSviewer, Bibliometrix, and Citespace software, we conducted bibliometric analysis and visualization of countries, institutions, authors, and keywords.
    RESULTS: Our analysis reveals a substantial increase in publications concerning nutrition and radiotherapy, with the United States and China leading in both publication volume and citation impact. The research focus has gradually shifted from phenomenological studies to mechanistic investigations, as evidenced by changes in keyword usage. While confirming the influence of nutritional status on radiotherapy outcomes, we also identified potential links to genomics, proteomics, metabolomics, and other omics disciplines.
    CONCLUSION: This study emphasizes the growing attention to the interplay between nutrition and radiotherapy in cancer treatment. Our findings suggest that further integration of multi-omics analysis can enhance understanding of the mechanisms underlying these interactions, providing a foundation for advancing cancer diagnosis and treatment strategies in the future.
    Keywords:  Citespace; Nutrition; Radiotherapy; Web of Science
    DOI:  https://doi.org/10.1016/j.biocel.2024.106687
  58. Heliyon. 2024 Nov 15. 10(21): e38927
       Background: Rectal cancer (RC) is one of the most common types of cancer worldwide. With the development of artificial intelligence (AI), the application of AI in preoperative evaluation and follow-up treatment of RC based on magnetic resonance imaging (MRI) has been the focus of research in this field. This review was conducted to develop comprehensive insight into the current research progress, hotspots, and future trends in AI based on MRI in RC, which remains to be studied.
    Methods: Literature related to AI based on MRI and RC, as of November 2023, was obtained from the Web of Science Core Collection database. Visualization and bibliometric analyses of publication quantity and content were conducted to explore temporal trends, spatial distribution, collaborative networks, influential articles, keyword co-occurrence, and research directions.
    Results: A total of 177 papers (152 original articles and 25 reviews) were identified from 24 countries/regions, 351 institutions, and 81 journals. Since 2019, the number of studies on this topic has rapidly increased. China and the United States have contributed the highest number of publications and institutions, cultivating the most intimate collaborative relationship. The highest number of articles derive from Sun Yat-sen University, while Frontiers in Oncology has published the highest number of relevant articles. Research on MRI-based AI in this field has mainly focused on preoperative diagnosis and prediction of treatment efficacy and prognosis.
    Conclusions: This study provides an objective and comprehensive overview of the publications on MRI-based AI in RC and identifies the present research landscape, hotspots, and prospective trends in this field, which can provide valuable guidance for scholars worldwide.
    Keywords:  Artificial intelligence; Bibliometry; Magnetic resonance imaging; Rectal cancer; machine learning
    DOI:  https://doi.org/10.1016/j.heliyon.2024.e38927
  59. Radiat Oncol. 2024 Nov 11. 19(1): 157
       BACKGROUND: Recent research has demonstrated that the use of artificial intelligence (AI) in radiotherapy (RT) has significantly streamlined the process for physicians to treat patients with tumors; however, bibliometric studies examining the correlation between AI and RT are not available. Providing a thorough overview of the knowledge structure and research hotspots between AI and RT was the main goal of the current study.
    METHOD: A search was conducted on the Web of Science Core Collection (WoSCC) database for publications pertaining to AI and RT between 2003 and 2023. VOSviewers, CiteSpace, and the R program "bibliometrix" were used to do the bibliometric analysis.
    RESULTS: The analysis comprised 615 publications from 64 countries, with USA and China leading the pack. Since 2017, there have been more and more publications about RT and AI every year. The research center that made the biggest contribution to this topic was Maastricht University. The most articles published journal in this field was Frontiers in Oncology, while Medical Physics received the greatest number of citations. Dekker Andre is the author with the greatest number of published articles, while Philippe Lambin was the most often co-cited author. In the newly identified research hotspots, "autocontouring algorithm", "deep learning", and "machine learning" stand out as the main terms.
    CONCLUSION: In fact, our bibliometric analysis offers insightful information on current research directions and advancements pertaining to the use of AI in RT. For academics looking to understand the connection between AI and RT, this study is a great resource because it highlights current research frontiers and hot trends.
    Keywords:  Artificial intelligence; Bibliometrics; Radiotherapy
    DOI:  https://doi.org/10.1186/s13014-024-02551-1
  60. Complement Ther Med. 2024 Nov 12. pii: S0965-2299(24)00098-0. [Epub ahead of print] 103110
       BACKGROUND: Acupuncture, a therapy created by the ancient Chinese, has been gaining increasing popularity and acceptance worldwid. The surge in the number of publications on acupuncture therapy has posed significant challenges for researchers in effectively managing the vast amount of information. This study aimed to analyze the themes and topics of the scientific publications related to acupuncture therapy in the past two decades by machine learning.
    METHODS: The MeSH term "Acupuncture Therapy" was used for searching publications from 1st January, 2004 to 31st December, 2023 on the PubMed database, while the R platform was adopted to obtain associated data. A topic network was constructed by latent Dirichlet allocation (LDA) and the Louvain algorithm.
    RESULTS: A total of 17,584 publications were finally recruited in this article. The publications were derived from 57 countries, with China, The United States and England being the top three countries. "Acupuncture Points", "Treatment outcome", "Electroacupuncture" were the most concerned MeSH terms. Four clusters and 50 branched topics were recognized by LDA and network analyses. "Comparative Efficacy", "Biochemical Analysis", "Symptomatic Treatment", "Professional Practice" and "Clinical Trials" are hotspots identified by LDA. "Neurotransmitter", "Meta-Analysis" and "Literature Review" have presented as new research hotspots.
    CONCLUSIONS: Acupuncture therapy has obtained increasing attention over the past two decades. Most of the studies focus on the mechanisms especially the analgesic and anti-inflammatory mechanisms, more researches such as "Neurotransmitter" will continue to advance. Besides, "meta-analysis" and "literature reviews" are increasingly common, providing more comprehensive and credible evidence for acupuncture therapy.
    Keywords:  LDA analysis; MeSH term; acupuncture therapy; bibliometric; machine learning; visualization analysis
    DOI:  https://doi.org/10.1016/j.ctim.2024.103110
  61. Autoimmun Rev. 2024 Nov 13. pii: S1568-9972(24)00182-4. [Epub ahead of print] 103691
       BACKGROUND: This study investigates global research on autoimmune/inflammatory syndrome induced by adjuvants (ASIA) to address gaps in disciplinary trends, research directions, and emerging topics, aiming to enhance understanding of ASIA's role in immune dysregulation and multi-system diseases.
    METHODS: This study uses bibliometric methods, based on data from the Web of Science (WOS) database, to analyze 203 ASIA-related publications from 2011 to 2024. Analytical tools, including VOSviewer, CiteSpace, and the bibliometrix R package, were employed to identify key research directions and frontier topics.
    RESULTS: Contributions from 40 countries, 318 institutions, and 824 researchers were analyzed, providing a global perspective on ASIA research. Israel contributed the highest publication volume, with Tel Aviv University being the most prolific contributor. Analysis showed that Immunologic Research published the most ASIA-related articles, whereas the Journal of Autoimmunity had the highest citation count. Keyword analysis identified six main research themes, including vaccine and adjuvant components, silicone implant-associated diseases, and connections between specific vaccines and autoimmune conditions. Thematic mapping highlighted key yet under-explored areas, such as immune responses to COVID-19 and HPV vaccines, and responses to specific adjuvants, offering insights into ASIA's complexity.
    CONCLUSION: This study provides a comprehensive analysis of ASIA's core themes and trends, highlighting key areas for future research, especially on the immune effects of vaccine adjuvants and implants. Although relying on a single data source, WOS's extensive coverage and citation tracking support the validity of these findings, laying a foundation for future ASIA research and clinical applications.
    Keywords:  ASIA syndrome; Adjuvants; Bibliometrics analysis; Frontier topics; Research directions
    DOI:  https://doi.org/10.1016/j.autrev.2024.103691
  62. Front Cardiovasc Med. 2024 ;11 1444466
       Background: Severe tricuspid regurgitation is a progressive disease with an unfavourable prognosis. In recent years there have been extraordinary gains in knowledge through both clinical and basic scientific work. We performed a bibliometric analysis on tricuspid regurgitation with a focus on imaging techniques and treatment approaches and to identify scientific milestones and emerging research trends.
    Methods: Publications, published between 2015 and 2023 were identified. Study characteristics, impact factors and countries of origin studies were recorded. Heat maps were created to visualise data and to identify leading centers. Most frequently cited publications were recognised as milestones.
    Results: We screened 3,519 studies. 368 studies were included, of which 326 were clinical studies. Clinical studies were further subdivided into interventional (n = 138), surgical (n = 115) or studies on imaging modalities (n = 74). We detected an enormous increase in scientific output worldwide, especially in imaging and interventional studies. The United States, Germany and Poland were identified as leading countries in imaging, interventions and preclinical studies respectively.
    Conclusions: Our study reflects the global gain in knowledge over the last 9 years. We were able to identify an annually rising number of interventional studies. Imaging studies have also seen a rapid increase, especially since 2020. In recent years, we monitored a decline in surgical studies.
    Keywords:  bibliometric analysis; edge-to-edge-treatment; heat maps; tricuspid regurgitation; tricuspid valve
    DOI:  https://doi.org/10.3389/fcvm.2024.1444466
  63. Asian J Surg. 2024 Nov 14. pii: S1015-9584(24)02508-9. [Epub ahead of print]
      
    Keywords:  Bibliometric analysis; Cardiovascular diseases; Environmental risk factors
    DOI:  https://doi.org/10.1016/j.asjsur.2024.10.175
  64. Medicine (Baltimore). 2024 Nov 08. 103(45): e39387
      To analyze the research status, hotspots, and trends of patient safety in the context of international telemedicine, and to provide reference for future research in various countries. The literature pertaining to patient safety within the realm of telemedicine was systematically retrieved from the Web of Science core collection database, encompassing the period from January 2010 to December 2023. Visual analysis of publication quantity, primary authorship, and keyword trends was conducted using CiteSpace (6.2R6) software. The geographical distribution of research focus was visualized through VOSviewer software and SCImago Graphica software, while research institutions were depicted using VOSviewer software and Highcharts software. Data organization was facilitated by Excel 2019 software. A total of 5356 related articles were included, and the number of published papers showed an overall upward trend, and the countries and institutions with the largest number of papers were the United States and Harvard University, respectively, and a stable core author research population had not yet been formed in this research field. Through keyword analysis, it can be seen that the research hotspots mainly focus on the research on the influencing factors of patient safety in the context of telemedicine, the research on the application value of telemedicine, and the research on coping strategies that affect patient safety. The research on patient safety in the context of telemedicine in foreign countries has a certain depth and breadth, which has important reference significance for improving the medical quality and patient safety of Internet hospitals in various countries.
    DOI:  https://doi.org/10.1097/MD.0000000000039387
  65. Front Oncol. 2024 ;14 1431636
       Introduction: Glioma represents the most prevalent primary malignant tumor in the central nervous system, a deeper understanding of the underlying molecular mechanisms driving glioma is imperative for guiding future treatment strategies. Emerging evidence has implicated a close relationship between glioma development and epigenetic regulation. However, there remains a significant lack of comprehensive summaries in this domain. This study aims to analyze epigenetic publications pertaining to gliomas from 2009 to 2024 using bibliometric methods, consolidate the extant research, and delineate future prospects for investigation in this critical area.
    Methods: For the purpose of this study, publications spanning the years 2009 to 2024 were extracted from the esteemed Web of Science Core Collection (WoSCC) database. Utilizing advanced visualization tools such as CiteSpace and VOSviewer, comprehensive data pertaining to various aspects including countries, authors, author co-citations, countries/regions, institutions, journals, cited literature, and keywords were systematically visualized and analyzed.
    Results: A thorough analysis was conducted on a comprehensive dataset consisting of 858 publications, which unveiled a discernible trend of steady annual growth in research output within this specific field. The nations of the United States, China, and Germany emerged as the foremost contributors to this research domain. It is noteworthy that von Deimling A and the Helmholtz Association were distinguished as prominent authors and institutions, respectively, in this corpus of literature. A rigorous keyword search and subsequent co-occurrence analysis were executed, ultimately leading to the identification of seven distinct clusters: "epigenetic regulation", "DNA repair", "DNA methylation", "brain tumors", "diffuse midline glioma (DMG)", "U-87 MG" and "epigenomics". Furthermore, an intricate cluster analysis revealed that the primary foci of research within this field were centered around the exploration of glioma pathogenesis and the development of corresponding treatment strategies.
    Conclusion: This article underscores the prevailing trends and hotspots in glioma epigenetics, offering invaluable insights that can guide future research endeavors. The investigation of epigenetic mechanisms primarily centers on DNA modification, non-coding RNAs (ncRNAs), and histone modification. Furthermore, the pursuit of overcoming temozolomide (TMZ) resistance and the exploration of diverse emerging therapeutic strategies have emerged as pivotal avenues for future research within the field of glioma epigenetics.
    Keywords:  CiteSpace; DNA methylation; TMZ; VOSviewer; epigenetics; glioma; therapeutic strategies
    DOI:  https://doi.org/10.3389/fonc.2024.1431636
  66. Environ Geochem Health. 2024 Nov 07. 46(12): 486
      The prevalence of microplastics (MPs) in agricultural ecosystems poses a notable threat to dynamics of soil ecosystems, crop productivity, and global food security. MPs enter agricultural ecosystems from various sources and have considerable impacts on the physiochemical properties soil, soil organisms and microbial communities, and plants. However, the intensity of these impacts can vary with the size, shape, types, and the concentrations of MPs in the soil. Besides, MPs can enter food chain through consummation of crops grown on MPs polluted soils. In this study, we conducted a bibliometric analysis of 1636 publications on the effects of MPs on agricultural ecosystems from 2012 to May 2024. The results revealed a substantial increase in publications over the years, and China, the USA, Germany, and India have emerged as leading countries in this field of research. Social network analysis identified emerging trends and research hotspots. The latest burst keywords were contaminants, biochar, polyethylene microplastics, biodegradable microplastics, antibiotic resistance genes, and quantification. Furthermore, we have summarized the effects of MPs on various components of agricultural ecosystems. By integrating findings from diverse disciplinary perspectives, this study provides a valuable insight into the current knowledge landscape, identifies research gaps, and proposes future research directions to effectively tackle the intricate challenges associated with MPs pollution in agricultural environments.
    Keywords:  Bibliometrics analysis; Microplastics; Remediation; Soil fauna; Soil properties
    DOI:  https://doi.org/10.1007/s10653-024-02274-y
  67. Cureus. 2024 Oct;16(10): e71213
      Mathematical neuroscience is the branch of interdisciplinarity between mathematical modeling and neuroscience through computational techniques to study the structure, function, and dynamics of the brain. The objective of this paper is to undertake a comprehensive review of research trends in mathematical neuroscience and important developments in the period from 1973 to 2024. From this source of bibliographic data, Scopus alone returns 727 retrieved documents, consisting of journals, book chapters, and conference papers. The analysis showed an annual growth rate of 6.51% in this field and significant contributions from authors of 1957 sources. Specific tools were used in this review for in-depth analysis of publication patterns, co-authorship networks, keyword co-occurrences, and thematic evolution within this discipline. The most influential authors, dominant publication sources, and most active countries in the field were identified. The survey also underlines various other emerging trends, of which the highly increasing approach to the integration of machine learning and artificial intelligence (AI) with mathematical neuroscience is certainly the most interesting. Results highlight the dynamic and collaborative features of research in this area and provide insight into the intellectual landscape for research in this field, along with its future directions.
    Keywords:  bibliometric analysis; biblioshiny; mathematical neuroscience; mathematics; neuroscience; vosviewer
    DOI:  https://doi.org/10.7759/cureus.71213
  68. Medicine (Baltimore). 2024 Nov 08. 103(45): e40457
       BACKGROUND: Buyang huanwu decoction (BYHWD) has shown significant clinical efficacy in the treatment of several diseases, particularly stroke. However, bibliometric research has not been comprehensive.
    METHODS: BYHWD articles were collected from literature databases published from January 1, 1915, to March 31, 2024, including the China National Knowledge Infrastructure, Weipu, Wanfang, Pubmed, Scopus, and Web of Science Core Collection. Knowledge network graphs of annual publication volume, authors, institutions, countries, keywords, and references were constructed.
    RESULTS: Nine thousand two hundred thirty-eight Chinese literature and 559 English articles published between 1915 and 2024 showed an overall upward trend. The countries, institutions, journals, and authors with the highest output were China, Hunan University of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangxian Cai, and Changqing Deng, respectively. Research teams outside China were located at Daejeon University, Gachon University, Aga Khan University, Yale University, etc. The results of keyword co-occurrence and burst analysis included clinical applications, animal experiments, action mechanisms, clinical efficacy, and safety evaluations based on systematic reviews and meta-analyses. Literature co-citation analysis revealed that BYHWD was highly correlated with neuroprotection and reduction of cerebral ischemia/reperfusion injury.
    CONCLUSION: Both Chinese and English literature have shown overall growth trend since 1984 and 1989, respectively. Clinical applications, pharmacological effects, mechanisms, active ingredients, evaluation of clinical efficacy and safety, modified BYHWD, methods, and biological techniques may be hotspots and focus of future research on BYHWD. Hotspot analytical methods and biological techniques include systematic reviews, meta-analyses, data mining, network pharmacology, and molecular docking. Future valuable research fields may include studies on neuroprotection, anti-inflammatory activity, ischemic stroke, bioactive compounds, and their underlying mechanisms.
    DOI:  https://doi.org/10.1097/MD.0000000000040457
  69. Autoimmun Rev. 2024 Nov 13. pii: S1568-9972(24)00179-4. [Epub ahead of print]23(12): 103688
      This study focuses on the search strategies used in bibliometric analyses within the field of autoimmune ear diseases, critically examining ways to improve search accuracy and relevance. Using the study by Liu et al. as an example, we found that the extensive search terms employed resulted in the inclusion of numerous irrelevant studies, weakening the specificity of the research findings. To address this issue, we propose a more precise search strategy using a combination of specific terms and wildcard symbols to ensure the search scope focuses on literature related to autoimmune ear diseases. Additionally, we recommend limiting search terms to titles, abstracts, and author keywords to reduce interference from unrelated literature. Moreover, we identify potential errors in keyword analysis caused by unmerged synonyms and suggest optimizing the accuracy of keyword co-occurrence analysis through synonym merging. This study aims to provide a more reliable methodological guide for future bibliometric analyses, thereby improving the quality and scientific rigor of research on autoimmune ear diseases.
    Keywords:  Autoimmune ear disease; Bibliometric analysis; Keyword consolidation; Precision research; Search strategy optimization
    DOI:  https://doi.org/10.1016/j.autrev.2024.103688
  70. J Dent. 2024 Nov 13. pii: S0300-5712(24)00634-1. [Epub ahead of print] 105464
       OBJECTIVES: To examine the frequency and features of presumed predatory orthodontic publications. We also aimed to assess the presence of these types of publications in established scientific databases.
    METHODS: Six electronic databases were searched to identify orthodontic articles published in 2022 in English. Equal numbers of articles from legitimate (n = 159) and suspect or predatory journals (n = 159) were considered. Data regarding journal, article and author characteristics were obtained. The indexing status of the publications in PubMed, Ovid, Embase, Web of Science, Scopus and EBSCOhost was evaluated. The total number of databases that the article was indexed in, level of evidence, origin of first author and research funding were recorded. Univariable ordinal regression analyses were performed to explore potential association between article legitimacy and indexing status.
    RESULTS: The majority of studies in predatory journals were found in non-specialized journals (79.6%). Scopus was the most porous database, indexing over half of predatory and suspect articles (56%). In Web of Science (Core collection), the distribution of articles across different indexing categories varied (SCIE; 16.4%, ESCI; 30.2%). In contrast, only 8.2% of these articles appeared in Medline. Articles in legitimate journals tended to have higher level of evidence and were indexed in more databases in comparison to predatory/suspect publications (OR=1.5; 95% CI: 1.37-1.64; p<0.01). The origin of the first author was a significant predictor for journal legitimacy (p<0.001).
    CONCLUSION: A high proportion of orthodontic publications appear in presumed predatory and suspect journals which are in turn often indexed in trustworthy databases. Medline was the least susceptible to predatory publications, while Web of Science and Scopus were more prone.
    CLINICAL SIGNIFICANCE: Predatory and suspect journals are increasingly prevalent with the penetration of these journals into recognized databases. We were able to identify associated trends.
    Keywords:  database indexing; ethics in publication; predatory publishing
    DOI:  https://doi.org/10.1016/j.jdent.2024.105464
  71. J Craniofac Surg. 2024 Nov 11.
       OBJECTIVE: This study aimed to compare the citation rates of open access (OA), and toll access (TA) articles published in the Journal of Craniofacial Surgery between 2019 and 2023, and to examine whether OA articles received more citations.
    METHODS: Using the Web of Science database, articles published in the Journal of Craniofacial Surgery between 2019 and 2023 were listed, excluding those with corrections or retractions. Articles were divided into 2 groups: OA and TA. The number of articles and citation counts for each group were analyzed by year. Citation rates were compared using the independent sample t test, with a p-value of <0.05 considered statistically significant.
    RESULTS: A total of 4691 articles were analyzed, of which 7.14% were OA and 92.86% were TA. Published in 2021, 2020, and 2019, OA articles had statistically significantly higher citation counts than TA articles. OA articles were found to be funded at a higher rate than TA articles.
    CONCLUSION: This study demonstrated that OA articles received more citations over time and were more likely to be funded. Although it is not definitively clear whether the citation advantage stems from the quality of the articles or their open-access status, the citation advantage of OA articles is striking.
    DOI:  https://doi.org/10.1097/SCS.0000000000010868
  72. Prosthet Orthot Int. 2024 Nov 08.
       BACKGROUND: Bone-anchored protheses (BAPs) by means of osseointegrated implants are increasingly being used in amputees with socket-related issues. Clinical advancements are being published by more and more centers worldwide. Although the number of publications and interest in BAP is growing, a systematic evaluation of scholarly output is lacking.
    OBJECTIVE: To identify scholarly output, understand research trends and make research recommendations in the clinical field of BAP.
    METHODS: Systematic searches in Medline All, Embase, Web of Science Core Collection, Cochrane Library, and Google Scholar were completed in February 2023. The results were deduplicated, screened, and assessed for quality by independent reviewers. Inclusion criteria were as follows: clinical studies and BAP in the extremities. Articles were excluded if they were animal or fundamental studies, nonclinical reports, had a study population less than 10 patients, or BAP was performed in areas other than extremities.
    RESULTS: One hundred twelve articles were included and published between 1993 and 2023. An annual growth rate of 10.3% was found and research was published in 62 different journals. Prosthetics and Orthotics International, Clinical Orthopaedics and Related Research and The Bone & Joint Journal were the most prolific journals. Hagberg K, Aschoff HH, and Branemark R were major contributors to BAP research. Collaborations are predominantly among high-income countries. Main research trends were on rehabilitation, questionnaires, complication managements, and implant treatment.
    CONCLUSIONS: Research on BAP shows an increasing global trend, highlighting key research areas and authors. A unified global research agenda, stakeholders' collaborations, and consensus are essential for addressing knowledge gaps and development future direction of BAP.
    DOI:  https://doi.org/10.1097/PXR.0000000000000410
  73. J Med Internet Res. 2024 Nov 15. 26 e60057
       BACKGROUND: As the digital health landscape continues to evolve, analyzing the progress and direction of the field can yield valuable insights. The Journal of Medical Internet Research (JMIR) has been at the forefront of disseminating digital health research since 1999. A comprehensive network analysis of JMIR publications can help illuminate the evolution and trends in digital medicine over the past 25 years.
    OBJECTIVE: This study aims to conduct a detailed network analysis of JMIR's publications to uncover the growth patterns, dominant themes, and potential future trajectories in digital health research.
    METHODS: We retrieved 8068 JMIR papers from PubMed using the Biopython library. Keyword metrics were assessed using accuracy, recall, and F1-scores to evaluate the effectiveness of keyword identification from Claude 3 Opus and Gemini 1.5 Pro in addition to 2 conventional natural language processing methods using key bidirectional encoder representations from transformers. Future trends for 2024-2026 were predicted using Claude 3 Opus, Google's Time Series Foundation Model, autoregressive integrated moving average, exponential smoothing, and Prophet. Network visualization techniques were used to represent and analyze the complex relationships between collaborating countries, paper types, and keyword co-occurrence.
    RESULTS: JMIR's publication volume showed consistent growth, with a peak in 2020. The United States dominated country contributions, with China showing a notable increase in recent years. Keyword analysis from 1999 to 2023 showed significant thematic shifts, from an early internet and digital health focus to the dominance of COVID-19 and advanced technologies such as machine learning. Predictions for 2024-2026 suggest an increased focus on artificial intelligence, digital health, and mental health.
    CONCLUSIONS: Network analysis of JMIR publications provides a macroscopic view of the evolution of the digital health field. The journal's trajectory reflects broader technological advances and shifting research priorities, including the impact of the COVID-19 pandemic. The predicted trends underscore the growing importance of computational technology in future health care research and practice. The findings from JMIR provide a glimpse into the future of digital medicine, suggesting a robust integration of artificial intelligence and continued emphasis on mental health in the postpandemic era.
    Keywords:  AI; Claude 3 Opus; JMIR publication analysis; NLP; algorithm; analytics; artificial intelligence; deep learning; digital; digital health; digital intervention; digital technology; eHealth; large language models; machine learning; mobile phone; model; natural language processing; network analysis; pandemic; postpandemic era; practical model
    DOI:  https://doi.org/10.2196/60057
  74. Plast Reconstr Surg Glob Open. 2024 Aug;12(8): e6023
       Background: Few dedicated, funded clinical research fellowship positions exist in plastic surgery. This study provides insights from an established clinical research fellowship, highlighting its educational impact and confirming the impact of positive institutional support and a collaborative-first approach.
    Methods: All research fellows within the program from 2008 to 2020 were examined during their year of employment and subsequent 2 years. Internal and external collaboration trends were assessed using PubMed affiliations. Correlation between external collaborations and research impact were examined. Research impact was characterized by publication count, journal impact factor, and journal diversity.
    Results: Thirty-one research fellows were identified, with a 100% match rate. Four phases of development were identified, and a three-period cycle of productivity was noted to occur every 3 years. A shift toward more external collaborations occurred after 2016 (P = 0.008). A positive correlation was observed between external collaborations and academic output (r = 0.72, P = 0.004), journal diversity (r = 0.74, P = 0.004), and journal impact (r = 0.63, P < 0.05). Significant growth was observed in the collaborative networks (P = 0.002), publications (P = 0.003), journal diversity (P < 0.001), and research personnel (P = 0.002).
    Conclusions: As a result of our strategic decision to engage collaborators across multiple disciplines, there is discernible improvement in measurable impact, contributing to the growth of our program. Dedicating resources to foster deeper collaborations can enrich the field of plastic surgery research, recognizing that this investment fuels the cycle of productivity, offering promising returns to the future.
    DOI:  https://doi.org/10.1097/GOX.0000000000006023
  75. East Mediterr Health J. 2024 Jul 17. 30(6): 430-439
       Background: Health systems research and publication are vital for improving healthcare at all levels of care. They provide evidence for policy and for better service outcomes.
    Aims: To assess published health systems research in Pakistan from 2011 to 2020 and to model and forecast the publication trend.
    Methods: This cross-sectional study searched health systems research publications database for Pakistan in Scopus using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. Tables and graphs were created using Microsoft Excel, visualization was produced on VoS Viewer, and SPSS version 29.1.0 was used for analysis, while R software was used to plot the time series data.
    Results: A total of 697 articles with an average of 16.6 citations were published between 2011 and 2020. The highest number of publications (240) per single institution was from Aga Khan University (including Aga Khan University Hospital), Karachi. There was a significant difference between the number of publications before and after the midpoint (2015) of the bibliometric analysis (t = -3.08, P = 0.015, 95% CI -87.78--12.61). We observed a strong relationship between publications and citations over the same period (Correlation coefficient 0.809, P = 0.002, CI 0.46-0.98) but there was no significant difference between the number of citations before and after the midpoint.
    Conclusion: There was an acute dearth of health systems research publication at the beginning of the study period. A few medical institutes are now taking the lead in conducting and publishing health systems research. Technical and financial support is needed to strengthen the capacity of Pakistani medical institutions and researchers to contribute more to knowledge generation within the country.
    Keywords:  Pakistan; health systems; healthcare; publication; research
    DOI:  https://doi.org/10.26719/2024.30.6.430
  76. Autoimmun Rev. 2024 Nov 08. pii: S1568-9972(24)00170-8. [Epub ahead of print]23(12): 103679
       BACKGROUND: In recent years, Autoimmune diseases (ADs) and hearing loss are both significant public health burdens worldwide. An increasing number of studies are focusing on the potential link between these two diseases and exploring how hearing loss can be prevented and treated in the context of autoimmune diseases. In response to this focus, it is very necessary to conduct bibliometric analysis and molecular mechanism exploration to provide guidance for the exploration of basic mechanisms and clinical management.
    METHOD: Studies focusing on hearing loss and autoimmune disease were extracted from the Web of Science Core Collection database from 2000 to 2024. Bibliometric and visual analysis of the collected publications was conducted using VOSviewer and CiteSpace. The investigation of molecular pathways associated with diseases was carried out in the GeneCards and STRING databases.
    RESULTS: A total of 696 papers met the inclusion and exclusion criteria and were chosen for further research. The number of papers on hearing loss and autoimmune diseases is increasing every year. These papers were mainly from 65 countries, led by the United States, China and Italy. These investigations included 3505 authors in total, with Greco A contributing the most publications. Harvard Medical School and Sapienza University Rome were the two institutions with the highest number of publications. Otology & Neurotology was the journal with the highest number of publications. The most common keywords include " sensorineural hearing loss", "endolymphatic hydrops", "management" and "autoimmune", which represent current and prospective future research trends and target topics in the field. Among them, the highest proportion of hearing loss in autoimmune ear diseases is sensorineural hearing loss, and the highest proportion of primary autoimmune ear diseases is Autoimmune inner ear disease. In addition, A total of 295 potential targets common to both diseases were also identified. Their pathogenesis involves cancer pathways, infectious disease pathways, cell senescence, epithelial and myocyte proliferation, hypoxia response, and inflammatory response.
    CONCLUSION: This bibliometric analysis reveals global research trends on hearing loss in the context of autoimmune diseases. Based on this, combined with preliminary bioinformatics analysis, a potential yet close link between the autoimmune diseases and hearing loss has been demonstrated. The current study highlights the need to fully consider the common genetic and pathophysiological mechanisms of these two types of diseases to promote interdisciplinary research and the development of personalized treatments for this clinical focus, with particular attention to the elderly population with comorbidity diseases. A deeper understanding of disease mechanisms has also led to advances in the clinical management of autoimmune ear diseases, including diagnosis and treatment.
    Keywords:  Autoimmune diseases; Bibliometric analysis; CiteSpace; Hearing loss; Mechanisms of co-morbidity; VOSviewer
    DOI:  https://doi.org/10.1016/j.autrev.2024.103679
  77. Front Cell Neurosci. 2024 ;18 1490607
       Background: Following ischemic stroke, non-neuronal cells within the nervous system play a crucial role in maintaining neurovascular unit functions, regulating metabolic and inflammatory processes of the nervous system. Investigating the functions and regulation of these cells, particularly immune cells, deepens our understanding of the complex mechanisms of neuroinflammation and immune modulation after ischemic stroke and provides new perspectives and methods for immune-related therapy.
    Methods: The annual distribution, journals, authors, countries, institutions, and keywords of articles published between 2015 and 2024 were visualized and analyzed using CiteSpace and other bibliometric tools.
    Results: A total of 1,089 relevant articles or reviews were included, demonstrating an overall upward trend; The terms "cerebral ischemia," "immune response," "brain ischemia," "cerebral inflammation," "neurovascular unit," and "immune infiltration," etc. are hot keywords in this field.
    Conclusion: In recent years, research on immune-related therapy for ischemic stroke has focused on mechanisms of occurrence, protection and repair of the blood-brain barrier (BBB) by non-neuronal cells, and regulation of immunosuppression and inflammation. Among these, reducing BBB disruption to minimize secondary brain damage has become a hotspot. At the same time, the complex roles of immune responses have attracted attention, particularly the balance between regulatory T cells and Th17 cells in regulating neuroinflammation and promoting neurological function recovery, which is crucial to reduce secondary neuronal damage and improve prognosis, potentially establishing a pivotal frontier in this domain of investigation.
    Keywords:  CiteSpace; bibliometrics; immune response; immune-related therapy; ischemic stroke; non-neuronal cells
    DOI:  https://doi.org/10.3389/fncel.2024.1490607
  78. J Eval Clin Pract. 2024 Nov 11.
       BACKGROUND: Medical humanities education is an integral component of medical education. However, the current landscape of research on medical humanities education remains incomplete. The purpose of this study is to identify the trends in research on medical humanities education and provide a global overview of the field by analysing various aspects such as sources, authors, literature, and keywords. The aim is to offer insights and recommendations for the future development of medical humanities education.
    METHODS: This research utilised bibliometric tools such as VOSviewer, CiteSpace, SciMAT, and the R software package biblioshiny to analyse literature sources, authors, documents, and keywords. This systematic review methodology allowed for a comprehensive examination of the field. Additionally, the study investigated international collaborations and scientific outputs, shedding light on the global landscape of medical humanities education research.
    RESULTS: The study included a total of 403 articles published between January 1980 and December 2023 from the Web of Science (WoS) database. The field of medical humanities education experienced an annual growth rate of 9.08% in literature output from 1980 to 2023, indicating its increasing prominence and scholarly interest over time. The research topics within this field have evolved in response to societal and medical developments. Core research themes that have consistently garnered attention from researchers include empathy, ethics, and narrative medicine, reflecting their significance and ongoing relevance in the field.
    CONCLUSION: These shifts in research hotspots signify the dynamic nature of the field, adapting to evolving contexts and emerging research domains. By embracing cross-cultural perspectives and fostering interdisciplinary collaborations, stakeholders in medical humanities education can collectively enrich the field, promote inclusivity, and enhance the overall educational experience for healthcare professionals.
    Keywords:  bibliometrics; medical education; medical humanities
    DOI:  https://doi.org/10.1111/jep.14239
  79. Asian J Surg. 2024 Nov 11. pii: S1015-9584(24)02421-7. [Epub ahead of print]
      Frozen shoulder (FS), characterized by pain and restricted mobility, remains a challenging condition with unclear optimal treatment. This study aims to investigate the development of FS research, identify hotspot treatments, and verify their efficacy. Analyzing 3139 FS-related publications from the Web of Science Core Collection revealed a significant rise in publications (R2 = 0.9478), with the United States as a leader in this research area. Our keyword analysis pinpointed suprascapular nerve block (SSNB) as a notable research focus since 2021. To assess the effectiveness of SSNB, we conducted a meta-analysis of eight randomized controlled trials including 435 patients. The results at the 6-8 weeks follow-up showed SSNB significantly reduced pain and improved active shoulder function compared to intra-articular corticosteroid injections (IACI). Specifically, SSNB led to considerable enhancements in abduction (SMD: 12.88; 95 % CI: 4.13, 21.64; p = 0.004; I2 = 54 %), flexion (SMD: 9.16; 95 % CI: 6.50, 11.82; p < 0.00001; I2 = 0 %), and external rotation (SMD: 18.03; 95 % CI: 6.59, 29.48; p = 0.008; I2 = 59 %). Additionally, there was a significant reduction in Shoulder Pain and Disability Index (SPADI) scores (SMD: 4.46; 95 % CIs: 7.75, -1.17; p = 0.008; I2 = 59 %). Despite these findings, no differences were observed in the improvement of passive activities between the SSNB and IACI groups at any follow-up. This study supports the short-term benefits of SSNB for FS, prompting further investigation into its long-term efficacy and comparison with other treatments.
    Keywords:  Bibliometrics; Frozen shoulder; Meta-analysis; Suprascapular nerve block
    DOI:  https://doi.org/10.1016/j.asjsur.2024.10.148
  80. J Nanobiotechnology. 2024 Nov 13. 22(1): 704
      As novel multifunctional materials that merge enzyme-like capabilities with the distinctive traits of nanomaterials, nanozymes have made significant strides in interdisciplinary research areas spanning materials science, bioscience, and beyond. This article, for the first time, employed bibliometric methods to conduct an in-depth statistical analysis of the global nanozymes research and demonstrate research progress, hotspots and trends. Drawing on data from the Web of Science Core Collection database, we comprehensively retrieved the publications from 2004 to 2024. The burgeoning interest in nanozymes research across various nations indicated a growing and widespread trend. This article further systematically elaborated the enzyme-like activities, matrix, multifunctional properties, catalytic mechanisms and various applications of nanozymes, and the field encounters challenges. Despite notable progress, and requires deeper exploration guide the future research directions. This field harbors broad potential for future developments, promising to impact various aspects of technology and society.
    Keywords:  Applications; Bibliometrics; Catalytic mechanism; Enzyme-like activity; Matrix; Multifunctional properties; Nanozymes; Research trend
    DOI:  https://doi.org/10.1186/s12951-024-02907-5
  81. Nutrients. 2024 Oct 30. pii: 3692. [Epub ahead of print]16(21):
       BACKGROUND: Caffeine is widely recognized as an ergogenic aid to enhance athletic performance, yet its effects in hot environments remain relatively underexplored.
    AIMS: To provide a comprehensive overview of the research landscape and identify research themes in this field.
    METHODS: We systematically searched the Web of Science (WoS) and SCOPUS databases using keywords related to caffeine (e.g., caffe*), hot environments (e.g., heat, hot, or therm*), and athletic performance (e.g., cardio, endurance, or strength). The Bibliometrix package in R was used for bibliometric analysis and result visualization, while a narrative review was subsequently performed to identify research themes.
    RESULTS: We found that studies examining the impact of caffeine on exercise in hot conditions are relatively sparse and have progressed slowly in recent years. Research in this domain has predominantly been concentrated within an academic network led by Professor Lawrence Armstrong. Recent contributions have been sporadically made by emerging scholars, with collaborations largely confined to a few research groups and countries. Key research themes identified include exercise performance, thermoregulation, fluid balance, physiological responses, immune responses, synergistic effects with other compounds, and the influence of individual differences. Of these, the first three themes-exercise performance, thermoregulation, and fluid balance-have received the most attention.
    CONCLUSIONS: Caffeine's effects on exercise performance in hot environments have not been thoroughly studied. The existing research themes are varied, and the conclusions show considerable inconsistencies. Our study highlights the need for further research into the effects of caffeine dosage, administration methods, and population-specific variables. We also call for increased collaboration among research groups to advance scientific understanding and address the gaps in this field.
    Keywords:  athlete; coffee; competition; exercise; health; nutrients; physical activity; sport
    DOI:  https://doi.org/10.3390/nu16213692
  82. Urology. 2024 Nov 13. pii: S0090-4295(24)01054-9. [Epub ahead of print]
       OBJECTIVES: To analyze the research productivity of 2024 urology residency applicants and its impact on match outcomes following the transition of the Step 1 exam to a Pass/Fail scoring system.
    METHODS: We conducted a retrospective review of PubMed-indexed publications for 98 applicants matched to the top 25 urology residency programs, as ranked by Doximity. Metrics such as the number of publications, citations, journal impact factors, and authorship rank were analyzed. Statistical comparisons of publication rates between top-ranked and lower-ranked programs were made using independent samples t-tests.
    RESULTS: The average number of publications per applicant was 5.95, with those entering top-ranked programs exhibiting higher research outputs. Most publications were found in journals like "Urology" and "Urology Practice." A significant portion of the research was published in the final year of medical school, indicating a push for paper acceptances prior to the urology application deadline date.
    DISCUSSION: The increase in research output among applicants reflects the shifting weights of factors important for residency competitiveness following the Step 1 Pass/Fail scoring changes. Early engagement and mentorship in research have been shown to increase the research output of students. The findings of this study clarify the research expectations of matching successfully into a top urology program and can be used by both medical students and program directors in the current and upcoming cycles.
    DOI:  https://doi.org/10.1016/j.urology.2024.11.011
  83. Heliyon. 2024 Nov 15. 10(21): e39352
      This study investigates the ephemeral and common features of public administration, reviews the development of public administration, identifies current research concerns, and explores future research directions. We gathered 89,905 documents from the SSCI database from the 1920s to 2020 and used co-word analysis to assess the evolution of the discipline of public administration over the past century. The popular concerns in the field of public administration are increasingly evident, particularly as they relate to performance evaluation, sector development, governance reform, governance equity, and strategic management. The future development of public administration will likely be more closely integrated with political science, and the related research will have a stronger preference for democratization.
    Keywords:  Co-words network; Power law; Public administration
    DOI:  https://doi.org/10.1016/j.heliyon.2024.e39352
  84. BMJ Lead. 2024 Nov 12. pii: leader-2023-000893. [Epub ahead of print]
       BACKGROUND: Despite efforts to advance equity, diversity and inclusion, women face gender-based barriers in research, including in neurology. Compared with men, women are less likely to hold leadership positions and be senior authors. Gender disparities in grant funding within neurology have yet to be investigated. We examine gender disparities in Canadian Institutes of Health Research (CIHR) funding for Canadian neurology divisions and departments.
    METHODS: Data on CIHR grant recipients and metrics (grant contribution, duration and quantity) within Canadian neurology divisions and departments between 2008 and 2022 were acquired from the CIHR Funding Decisions Database. Gender identity was determined by a validated application programming interface. Gender-based differences in CIHR grant contribution amount, duration and prevalence within neurology were calculated. Subgroup analysis was conducted for Canadian-licensed neurologists and Project Grant awards.
    RESULTS: 1604 grants were awarded to Canadian neurology divisions and departments between 2008 and 2022. Compared with men, women received less funding (p<0.0001), shorter grant durations (p<0.0001) and fewer grants (41.5%) annually. Women comprised the minority of recipients (45.5%) and were less likely to be awarded grants (p<0.001) annually relative to men. Differences were consistent in subgroup analyses, except for equal grant durations observed across genders in Project Grant awards.
    CONCLUSION: We report gender disparities in CIHR grant funding to Canadian neurology divisions and departments. Women receive lower contribution amounts, shorter grant durations and fewer grants than men. Future recommendations include addressing gender differences and continuing to evaluate CIHR funding to provide equal opportunities for women in research and funding.
    Keywords:  career development; clinical leadership; medical leadership; research; trainees
    DOI:  https://doi.org/10.1136/leader-2023-000893
  85. Saudi Pharm J. 2024 Nov;32(11): 102188
      Captagon is a synthetic stimulant combining amphetamine and theophylline. Initially introduced in 1961 as a treatment for hyperactivity, depression, and narcolepsy, Captagon was later classified as a Schedule 1 controlled substance due to its addictive and hallucinogenic properties. Despite its global prohibition in 1986, the trade of counterfeit products is widespread, especially in south-east Europe and far-east Asia, with its production being on the rise in Middle Eastern regions. This paper presents a quantitative data-driven bibliometric analysis of the existing literature on Captagon up to July 2024. It aims to delineate the structure and development of knowledge surrounding the substance, including key contributing countries, authors, prominent sources, and recurring thematic keywords. The quantitative and data-driven results were then used to guide the narrative discussion on Captagon. Findings indicate that current research predominantly focuses on Captagon's use and impact in conflict zones, often exploring its interaction with other substances used by civilians and militias. Results also show a growing trend in Captagon research, with Saudi Arabia, Jordan, and Iraq emerging as main contributors to the literature. Despite the attention in specific regions, a considerable gap remains in understanding the mechanisms of action of Captagon (particularly regarding its metabolism, toxicology, mortality risk), and in developing protocols for its discontinuation. Additionally, the drug's inconsistent composition requires further analyses to better predict risks and establish effective management strategies. Addressing these gaps will be crucial for the development of novel interventions and policies to mitigate the adverse effects of Captagon and improve public health systems worldwide.
    Keywords:  Addiction science; Bibliometrics; Captagon; Fenethylline; Narrative review
    DOI:  https://doi.org/10.1016/j.jsps.2024.102188
  86. Digit Health. 2024 Jan-Dec;10:10 20552076241297729
       Objective: Australia is committed to establishing a digitally enabled healthcare system that fosters innovation, strengthens data capabilities, and establishes a foundation for future digital health reform. This study provides a comprehensive overview of digital health implementation research in Australia, employing scientometric analysis and data visualization. We assess the existing knowledge base, identify key research areas and frontier trends, and explore their implications for healthcare delivery in rural and remote settings.
    Methods: A systematic search of the Web of Science Core Collection database was conducted for relevant documents up to December 31, 2023. Analysis of annual growth patterns, journals, institutional and authorship contributions, reference co-citation patterns, and keyword co-occurrence was conducted using scientometrics to create outputs in the form of graphs and tables. Evolutionary analyses were undertaken to delineate the current knowledge base, predominant research themes, and frontier trends in the field.
    Results: A total of 196 documents related to digital health implementation in Australia were identified, demonstrating sustained growth since 2019. The evolution of the field is characterized by four distinct phases, with a pronounced focus on telehealth, particularly in the context of the COVID-19 pandemic. 'Remote health' emerged as a significant area of contemporary interest.
    Conclusions: This scientometric study contributes to our understanding of digital health implementation research in Australia. Despite a considerable body of research, there remains a relative paucity of studies focused on implementation in underserved rural and remote areas which arguably stand to benefit the most from digital health advancements. Continued research in this field is crucial to ensure equitable access to the benefits offered by digital health innovations.
    Keywords:  Australia; Digital health; healthcare delivery; implementation science; knowledge discovery
    DOI:  https://doi.org/10.1177/20552076241297729
  87. Heart Rhythm. 2024 Nov 08. pii: S1547-5271(24)03549-5. [Epub ahead of print]
      
    Keywords:  Bibliometrics(4); Cardiac Resynchronization Therapy(5); Conduction system pacing(3); His-bundle pacing(1); Traditional pacing (2)
    DOI:  https://doi.org/10.1016/j.hrthm.2024.11.007
  88. F1000Res. 2022 ;11 107
       Background: The EMPIRE (EMpirical Publication Impact and Reach Evaluation) Index is a value-based, multi-component metric framework to assess the impact of medical publications in terms of relevance to different stakeholders. It comprises three component scores (social, scholarly and societal impact), each incorporating related altmetrics that indicate a different aspect of engagement with the publication. Here, we present an exploratory investigation of whether publication types or disease indications influence EMPIRE Index scores.
    Methods: Article-level metrics were extracted and EMPIRE Index scores were calculated for 5825 journal articles published from 1 May 2017 to 1 May 2018, representing 12 disease indications (chosen to reflect a wide variety of common and rare diseases with a variety of aetiologies) and five publication types.
    Results: There were significant differences in scores between article types and disease indications. Median (95% CI) social and scholarly impact scores ranged from 1.2 (0.3-1.6) to 4.8 (3.1-6.6), respectively, for phase 3 clinical trials, and from 0.3 (0.3-0.4) to 2.3 (1.9-2.6), respectively, for observational studies. Social and scholarly impact scores were highest for multiple sclerosis publications and lowest for non-small cell lung cancer publications. Systematic reviews achieved greater impact than regular reviews. Median trends in the social impact of different disease areas matched the level of public interest as assessed through Google search interest. Although most articles did not register societal impact, mean societal impact scores were highest for migraine publications.
    Conclusions: The EMPIRE Index successfully identified differences in impact by disease area and publication type, which supports the notion that the impact of each publication needs to be evaluated in the context of these factors, and potentially others. These findings should be considered when using the EMPIRE Index to assess publication impact.
    Keywords:  Altmetrics; bibliometrics; publication impact
    DOI:  https://doi.org/10.12688/f1000research.75805.5
  89. Dent Mater. 2024 Nov 06. pii: S0109-5641(24)00305-1. [Epub ahead of print]
       OBJECTIVES: The review assess the potential of hydrogel-based drug delivery systems in treating periodontitis. Hydrogels are classified based on source, composition, configuration, crosslinking methods, ionic charge, and response to stimuli.
    METHODS: The methodology comprised of comprehensive data collection from WoS, Scopus and PubMed databases covering the period of 2004-2024 of 626 documents. A bibliometric analysis was conducted using VOS Viewer to identify research trends, key contributors, prominent topics, and leading journals. A comparative analysis was performed to examine the benefits of hydrogels over conventional periodontitis treatments. Current research and innovations in hydrogel formulations were reviewed, including ongoing clinical trials and commercial products.
    RESULTS: China was found to be the leading contributor to hydrogel research in periodontitis, with key topics including "hydrogels," "nanoparticles," and "drug delivery." A detailed classification system for hydrogels was established, aiding in their application for targeted drug delivery and tissue regeneration. Hydrogels were found to offer controlled drug release, support for tissue regeneration, and improved clinical outcomes compared to traditional treatments. Innovations highlighted including the use of various polymers like nano-hydroxyapatite/collagen composites, PLGA-based materials, and chitosan gels in clinical trials, demonstrating enhanced cell proliferation and tissue regeneration.
    SIGNIFICANCE: This review underscores the significant potential of hydrogel-based therapies in advancing the treatment of periodontitis. By providing a comprehensive bibliometric analysis and highlighting key research and innovations, it emphasizes the advantages of hydrogels in terms of targeted drug delivery, minimal invasiveness, and support for tissue regeneration. The findings suggest that with further clinical trials and regulatory approvals, hydrogels could become a mainstream, effective treatment option for periodontitis, offering improved patient outcomes and potentially transforming periodontal therapy.
    Keywords:  Bibliometric analysis; Drug delivery; Hydrogels; Nanoparticles; Periodontitis; VOS viewer
    DOI:  https://doi.org/10.1016/j.dental.2024.10.017
  90. Neurosurgery. 2024 Nov 11.
       BACKGROUND AND OBJECTIVES: Scholarship has been critical to neurosurgery. As grades and board examinations become pass-fail, finding metrics to distinguish applicants coupled with an emphasis on research has led to growth of reported academic output among neurosurgery applicants. We aimed to evaluate applicant factors that associate with an academically productive neurosurgery resident.
    METHODS: Applicant characteristics were extracted from Electronic Residency Application Service archives from 2 geographically distinct neurosurgical programs for the 2014 to 2015 match cycle. Publications during residency were quantified, and residency careers were examined. Factors associated with residency publications were examined using univariate and multivariate regressions.
    RESULTS: A total of 228 United States (US) applicants to neurosurgery were assessed (89% of US neurosurgery applicants), with 173 matching across 93 programs. The average publication number of matched applicants was higher at 6.6 (median: 4, range: 0-43) that of than unmatched applicants (mean: 2.9, median: 1, range: 0-51). A total of 93.1% of publications were substantiated on PubMed review. Matched candidates published 19.3 manuscripts (median: 13, range: 0-120) on average during residency. On univariate analysis, factors associated with higher residency publications included taking a non-degree-granting extra year for research in medical school, consistently high clerkship grades, depth of preresidency research involvement, number of coresidents, program R25 status, and academic output of neurosurgery department leadership. After multivariate correction, the training environment played an outsized role in predicting resident academic output, with program R25 status significantly associated with resident academic output (odds ratio: 1.25, P = .012). Taking an extra research year in medical school approached but was not significant (odds ratio: 1.19, P = .099). Twelve matched international medical school graduates (IMGs) were also assessed (75% of matched IMG neurosurgery applicants). IMGs exhibited higher total publications and conference abstracts than US matched applicants and also published more during residency.
    CONCLUSION: Cultivating an environment that promotes research endeavors is critical for neurosurgical resident academic growth. Preresidency publication number does not predict publication potential during residency.
    DOI:  https://doi.org/10.1227/neu.0000000000003251
  91. Geohealth. 2024 Nov;8(11): e2024GH001028
      Planetary Health (PH) is a relatively new field that studies the sciences behind the interaction between the environment, living organisms, and human health. The number of publications in this field has increased exponentially in the past few years. This study analyzed the trend of using the term "PH" in literature. We searched PubMed for all publications (APP) and those mentioning Planetary Health (APmPH) without limitations on text availability, dates, or species. The publication trend was estimated using the average annual percent change (AAPC). Joinpoint Regression Program 4.9.1.0 identified periods with statistically distinct log-linear trends in publication numbers over time. Bonferroni adjustment determined significant trend shifts. The time frame of the retrieved APP and APmPH results ranged from 2002 to 2022 with a publication boom since 2017. The most common study designs were reviews, followed by comments and editorials. The APP, APmPH, and the proportion of APmPH to APP steadily increased from 2002 to 2022, with an AAPC of 6.0% (95% CI: 4.4%-7.6%, p < 0.001), 35.7 (95% CI: 21.3%-51.9%, p < 0.001), and 28.1% (95% CI: 15.2-42.5, p < 0.001), respectively. The term "PH" is increasingly prominent in academic literature, underscoring the need for interdisciplinary efforts. Its growing usage also highlights the need for recognition in Medical Subject Headings by the National Library of Medicine.
    Keywords:  joint‐point analysis; planetary health; publication trend
    DOI:  https://doi.org/10.1029/2024GH001028
  92. Plast Reconstr Surg Glob Open. 2024 Nov;12(11): e6303
       Background: Timely distribution of research is crucial for improving treatments and patient care; however, the publication process is historically unhurried. The primary goal of this study was to analyze the time to publication in hand surgery for 5 years and to examine potential factors affecting publication speed.
    Methods: A 5-year review (2017-2021) was performed on 4 major hand surgery journals. The Journal of Hand Surgery American Volume, Journal of Hand Surgery European Volume, Journal of Plastic Surgery and Hand Surgery, and Plastic and Reconstructive Surgery were included in the review. Differences were assessed using analysis of variance or 2-sided independent t tests for continuous variables.
    Results: There was a significant difference in submission-to-publication time between journals (P < 0.001). This differed by year (P < 0.001), with a significant increase in time from submission to publication after 2019, during the COVID-19 pandemic (447 ± 198 versus 406 ± 169 d, P < 0.001). Geographic region of the primary institution did affect submission-to-publication time (P < 0.001). No significant difference was seen in submission-to-publication time based on the number of institutions contributing, article type, or first author or corresponding author surgical specialty (P > 0.05).
    Conclusions: Time to publication in hand surgery varies by hand surgery journal and significantly increased during the COVID-19 pandemic. New research reflects work done over a year ago at least. Participation in the peer-review process should be encouraged and bolstered within the hand surgery community to improve research dissemination times within the field.
    DOI:  https://doi.org/10.1097/GOX.0000000000006303
  93. Animals (Basel). 2024 Nov 04. pii: 3158. [Epub ahead of print]14(21):
      Methane (CH4) from livestock, particularly enteric CH4 emission (EME), is one contributor to greenhouse gas emissions and climate change. This review analyzed 1294 scientific abstracts on EME in ruminants from 1986 to May 2024, using Scopus® data. Descriptive statistics, text mining, and topic analysis were performed. Publications on EME have risen significantly since 2005, with the Journal of Dairy Science being the most frequent publisher. Most studies (82.1%) were original research, with Northern Hemisphere countries leading in publication numbers. The most frequent terms were "milk", "cow", and "diet", while key research topics included greenhouse gas emissions from livestock, diet composition, and prediction models. Despite progress, some areas like CH4 emission from animals need further investigation.
    Keywords:  enteric methane; machine learning; ruminants; text mining; topic analysis
    DOI:  https://doi.org/10.3390/ani14213158
  94. Am J Ophthalmol. 2024 Nov 06. pii: S0002-9394(24)00518-X. [Epub ahead of print]
       PURPOSE: To assess the prevalence of Artificial Intelligence (AI) usage policies in manuscript writing in PubMed-indexed ophthalmology journals and examine the relationship between adoption of these policies and journal characteristics.
    DESIGN: Cross-sectional study SUBJECTS: PubMed-indexed ophthalmology journals MAIN OUTCOME MEASURES: Prevalence of policies in journal guidelines regarding the use of AI in manuscript writing.
    METHODS: We reviewed the guidelines of 84 ophthalmology journals indexed in PubMed to determine the presence of AI-use policies for manuscript generation. We further compared journal metrics, such as CiteScore, Journal Impact Factor (JIF), Journal Citation Indicator (JCI), Source Normalized Impact per Paper (SNIP), and SCImago Journal Rank (SJR), between journals with and without AI policies. Additionally, we analyzed the association between AI policy adoption and journal characteristics, such as MEDLINE indexing and society affiliation.
    RESULTS: Among the 84 journals, 53 (63.1%) had AI policies for manuscript generation, with no significant changes observed during the study period. Journals indexed in MEDLINE were significantly more likely to have AI policies (68.8%) than non-MEDLINE-indexed journals, where no AI policies were found (0%) (p = 0.0008). There was no significant difference in AI policy adoption between society-affiliated (62.7%) and unaffiliated journals (64.7%) (p = 0.8443). Journals with AI policies had significantly higher metrics, including CiteScore, SNIP, SJR, JIF, and JCI (p < 0.05).
    CONCLUSIONS: While many ophthalmology journals have adopted AI policies, the lack of guidelines in over one-third of journals highlights a critical need for consistent and comprehensive AI policies, particularly as the AI landscape rapidly advances.
    Keywords:  AI; AI Disclosure; AI Ethics; AI Policies; AI and Healthcare; AI in Research; AI-assisted Research; Artificial Intelligence; Ethical Standards; Journal Guidelines; MEDLINE Indexing; Medical Journals; Ophthalmology; PubMed Indexed Journals; Research Integrity; Scientific Publishing
    DOI:  https://doi.org/10.1016/j.ajo.2024.11.003
  95. JB JS Open Access. 2024 Oct-Dec;9(4):pii: e24.00075. [Epub ahead of print]9(4):
       Introduction: Although clinical research has traditionally been a part of orthopaedic residency, there are now certain core requirements created by the Accreditation Council for Graduate Medical Education (ACGME), which outline the type of research activities to be completed during residency. However, there are no specific details included in the ACGME guidelines regarding how these milestones are to be met. Nor is there specificity regarding expectations of scholarly activity to be completed by the time of graduation. There is a paucity of literature demonstrating the effectiveness of implementing a dedicated research block in an orthopaedic surgical residency, especially in the community setting where limited research-related resources are available.
    Methods: We implemented a dedicated research rotation along with a set of research milestones and guidelines at our single orthopaedic surgery community residency program. A search was performed through PubMed using residents' and faculty members' names to find publications included a 7-year period from 2015 to 2022 to determine number of publications by residents and faculty. Scholarly activity of faculty was analyzed and quantified using self-reported annual surveys.
    Results: The average annual number of resident publications (by all 25 residents) increased from 2 to 26 after implementation of a dedicated research rotation. Faculty's scholarly activity, as measured by the following criteria, increased as well: number of publications (from 22 to 55), conference presentations (from 51 to 83), and other presentations (from 43 to 72).
    Conclusion: Implementation of a dedicated research rotation in a community orthopaedic residency program is associated with an increased publication rate in major academic journals among residents and faculty. There is also an observed association with implementation of a dedicated resident research rotation and an increase in faculty scholarly activity satisfying ACGME faculty requirements.
    DOI:  https://doi.org/10.2106/JBJS.OA.24.00075
  96. Plast Reconstr Surg Glob Open. 2024 Aug;12(8): e6013
       Background: It is increasingly apparent that plastic surgery residency applications with lengthy research publications are the new standard in applicant competitiveness. This study aims to evaluate the research history of plastic surgery program faculty leadership to understand the trends and evolution of research expectations.
    Methods: The curriculum vitaes of faculty involved in residency admissions among all US Accreditation Council for Graduate Medical Education-accredited integrated and independent plastic surgery programs were reviewed. Doximity, program websites, and Scopus were used to gather information. H-index and publication count at the time of medical school and residency graduations were collected. Student t test and Pearson product-moment correlation were used for analysis.
    Results: Of the 236 plastic surgeons considered, faculty averaged one publication by medical school graduation, two by general surgery residency graduation, and six by plastic surgery residency graduation. Integrated residents held more publications after medical school (1.67 versus 0.56; P = 0.09) and plastic surgery residency (8.48 versus 4.89; P = 0.01) compared with independent residents. Later plastic surgery residency graduation year correlated with more publications (P < 0.001). Chairs had higher h-indices compared with program directors and associate positions (chair: 23.7, program director: 14.7, associate: 12.2; P < 0.001).
    Conclusions: The majority of faculty leaders' research was published after residency. The emerging trend of increased research volume among plastic surgeons-in-training may be a consequence of competitive research requirements to matriculate into residency. Longer-term career follow-up of newer graduates will need to be assessed to determine whether this predicts future postgraduate productivity or if it is just the price of admission to train as a plastic surgeon.
    DOI:  https://doi.org/10.1097/GOX.0000000000006013
  97. Eur Arch Otorhinolaryngol. 2024 Nov 11.
      
    Keywords:  Career; Gender disparity; Leadership; Otolaryngology; Publications
    DOI:  https://doi.org/10.1007/s00405-024-09064-3
  98. West Afr J Med. 2024 Nov 10. pii: West Afr J Med.. [Epub ahead of print]41(11 Suppl 1): S10
       Background: Continuous evidence-based research is crucial in medical education, guiding clinical practice and informing healthcare policy. It is a core pillar of postgraduate academia. Despite the need to generate and disseminate quality scientific evidence, there is a significant disparity in research engagement and publication rates, with a small fraction of scholars contributing the majority of publications. This imbalance is particularly evident in regions like Nigeria, where health research output and its translation into policy fall short of expectations.
    Aim: This study aimed to assess research engagement, and productivity, and to identify associated factors and challenges influencing publication among postgraduate doctors at the University of Nigeria Teaching Hospital (UNTH), Enugu, Nigeria.
    Methodology: A cross-sectional descriptive study involving 241 postgraduate doctors affiliated with UNTH was conducted. Data were collected using a quantitative electronic self-administered survey tool, which gathered information on participants' sociodemographic profiles, research activities, factors enabling publication success, and encountered challenges. Data analysis was performed using SPSS Version 23.0, with Pearson correlation employed to examine associations between research productivity and variables such as age, years of academic experience, and professional level.
    Results: The findings revealed that 88.4% of respondents had engaged in research, but only 54.9% had successfully published their work. Significant barriers to research productivity included time constraints, poor mentorship, inadequate funding, and insufficient research writing skills, poor institutional support and infrastructures. Positive correlations were observed between research output and factors like age, professional experience, and years in academia, indicating that seniority positively influences research productivity.
    Conclusion: This study highlights the need for improved mentorship, grant-writing support, and institutional resources to enhance research productivity among postgraduate doctors in Nigeria.
    Keywords:  Academic experience; Barriers; Healthcare policy; Mentorship; Nigeria; Postgraduate doctors; Productivity; Research engagement
  99. Arthroscopy. 2024 Nov 13. pii: S0749-8063(24)00956-3. [Epub ahead of print]
      With sincere appreciation to the Arthroscopy Association of North America Education Foundation for their support, we present Arthroscopy's 2025 Annual Awards for the best Clinical Research, Basic Science Research, Resident/Fellow Research, Systematic Review, and Podcast published in 2024, as well as the Most Downloaded and Most Cited papers published 5 years ago in Arthroscopy, and the Most Downloaded Arthroscopy Techniques article. In addition, as of January 1, 2025, we have updated our Editor-in-chief, Assistant Editor, and Deputy and Associate Editors disclosures of potential conflicts of interest as well as our journal masthead.
    DOI:  https://doi.org/10.1016/j.arthro.2024.11.052
  100. Clin Exp Dent Res. 2024 Dec;10(6): e70040
       OBJECTIVES: Modified Dental Anxiety Scale (MDAS) is a frequently used psychometric tool to evaluate the dental anxiety level of dental patients or the general population. However, it was largely unclear if MDAS was consistently administered in the original format in the academic literature. This work aimed to survey the literature published in the last 10 years to reveal the current usage of MDAS.
    METHODS: Web of Science and Scopus were queried to identify papers that mentioned the use of MDAS.
    RESULTS: Among a total of 260 analyzed papers, 101 papers included comprehensive information regarding both the questions posed and the response format employed. Two papers only used an explicitly renamed MDAS with modified contents. Among the 258 papers that used MDAS that were supposed to be standardized, many discrepancies from the original version were discovered. There were only 39 papers that strictly followed the recommended scoring scheme: if a participant had a score of ≥ 19, he or she might be highly dentally anxious. Notable modifications included the use of a cut-off score different from the original recommendation, the use of multiple cut-off scores, modifications of the response format or descriptors, and modifications to the question items especially adding extra questions.
    CONCLUSIONS: These modifications would create confusion when researchers and clinicians tried to compare data across studies. Researchers are recommended to administer MDAS in its original format.
    Keywords:  Bibliometric analysis; Dental anxiety; Ethics; Modified Dental Anxiety Scale; Public Health; Research; Responsible research
    DOI:  https://doi.org/10.1002/cre2.70040
  101. Int J Mol Sci. 2024 Oct 24. pii: 11421. [Epub ahead of print]25(21):
      Cyclic dipeptides (CDPs), known for their diverse biological activities, have potential therapeutic applications in mental and behavioral disorders (MBDs), particularly schizophrenia. This study explores the CDPs' therapeutic potential using bibliometric analysis, network pharmacology, molecular docking, and experimental verification, focusing on the interactions with the SIGMA1 receptor. A literature review over three decades utilizing the Web of Science Core Collection (WOSCC) was conducted to identify the emerging trends in CDPs research. A compound library was constructed from the PubChem database, and target prediction using SwissTargetPrediction revealed 800 potential protein targets. A compound-target network highlighted the key interactions with kinases, G protein-coupled receptors, and chromatin-modifying enzymes. Enrichment analysis revealed significant associations with schizophrenia and other MBDs. Schizophrenia-related targets among the potential protein targets were identified using the GEO database. Molecular docking results showed interactions of MC4R, OPRK1, SIGMA1, and CDK5R1 with various CDPs compounds, with SIGMA1 being especially noteworthy. Most CDPs exhibited lower binding energies than the control compounds NE-100 and duloxetine. Experimental validation demonstrated that CDPs such as Cyclo(Ala-Gln), Cyclo(Ala-His), and Cyclo(Val-Gly) exhibited IC50 values of 13.4, 19.4, and 11.5 μM, respectively, against SIGMA1, indicating biological activity. Our findings underscore their potential as therapeutic agents for schizophrenia, highlighting the need for further modifications to enhance specificity and efficacy. This work paves the way for future investigations into CDPs, contributing to developing targeted treatments for schizophrenia and related mental health disorders.
    Keywords:  SIGMA1 binding assay; bibliometric analysis; cyclic dipeptides; molecular docking; network pharmacology; pharmacological activities; schizophrenia
    DOI:  https://doi.org/10.3390/ijms252111421
  102. Nefrologia (Engl Ed). 2024 Sep-Oct;44(5):pii: S2013-2514(24)00195-0. [Epub ahead of print]44(5): 764-766
      
    DOI:  https://doi.org/10.1016/j.nefroe.2024.11.002
  103. Foods. 2024 Oct 31. pii: 3496. [Epub ahead of print]13(21):
      In recent years, the worldwide plant-based meat sector has undergone substantial and rapid expansion. The swift advancement of plant-based meat products in the Chinese market is ascribed to changes in customer dietary preferences. To accelerate the rapid expansion of China's plant-based meat sector, it is essential to conduct research on consumer demand trends. Citespace was utilized in this study to conduct a bibliometric analysis of research pertaining to plant-based meat. A study model was then created to analyze the primary elements affecting the consumption behavior of plant-based meat products. This study employs Zhengzhou as a case study to construct a research model to examine consumers' inclination to purchase plant-based meat products. The model is derived from survey data obtained from 570 consumers. The findings indicate that the characteristics of plant-based meat products significantly influence consumers' purchase intentions and consumption behaviors by shaping their perceptual activity. Price rationality, technical security, and flavor richness are three principal factors influencing customer purchasing of plant-based meat products. The perceived value and trust of consumers can somewhat mediate the influence of plant-based meat consumption behavior. This study offers significant insights into purchasing intentions and consumer behavior in first-tier cities in China. The outcomes of this study can provide a beneficial framework for imitation meat producers to improve product development and stimulate customer interest in the plant-based meat market.
    Keywords:  bibliometric analysis; consuming behavior; plant-based meat; structural equation modeling
    DOI:  https://doi.org/10.3390/foods13213496
  104. J Am Board Fam Med. 2024 Nov 15. pii: jabfm.2024.240085R1. [Epub ahead of print]
      Evaluating research activity in research departments and education programs is conventionally accomplished through measurement of research funding or bibliometrics. This limited perspective of research activity restricts a more comprehensive evaluation of a program's actual research capacity, ultimately hindering efforts to enhance and expand it. The objective of this study was to conduct a scoping review of the existing literature pertaining to the measurement of research productivity in research institutions. Using these findings, the study aimed to create a standardized research measurement tool, the Productivity And Capacity Evaluation in Research (PACER) Tool. The evidence review identified 726 relevant articles in a literature search of PubMed, Web of Science, Embase, ERIC, CINAHL, and Google Scholar with the keywords "research capacity" and "research productivity." Thirty-nine English-language studies applicable to research measurement were assessed in full and 20 were included in the data extraction. Capacity/productivity metrics were identified, and the relevance of each metric was data-charted according to 3 criteria: the metric was objective, organizational in scale, and applicable to varied research domains. This produced 42 research capacity/productivity metrics that fell into 7 relevant categories: bibliometrics, impact, ongoing research, collaboration activities, funding, personnel, and education/academics. With the expertise of a Delphi panel of researchers, research leaders, and organizational leadership, 31 of these 42 metrics were included in the final PACER Tool. This multifaceted tool enables research departments to benchmark research capacity and research productivity against other programs, monitor capacity development over time, and provide valuable strategic insights for decisions such as resource allocation.
    Keywords:  ADFM/NAPCRG Research Summitt 2023; Benchmarking; Bibliometrics; Capacity Building; Efficiency; Health Care Quality Indicators; Health Personnel; Leadership; Research Personnel; Resource Allocation; Systematic Review
    DOI:  https://doi.org/10.3122/jabfm.2024.240085R1
  105. East Mediterr Health J. 2024 Jul 17. 30(6): 414-423
       Background: Several bibliometric analyses have been conducted in the Eastern Mediterranean Region (EMR), however, there is limited data from such analyses for the establishment of national or regional health research agenda.
    Aim: To assess the biomedical and health research outputs in EMR countries for 2004-2018 and their alignment with the regional strategic health priority areas identified by the WHO Regional Office for the Eastern Mediterranean.
    Methods: We searched and reviewed health-related articles indexed in PubMed and originating from EMR countries from 2004 to 2018 and used these as indicators of the country's total biomedical research publication level. Data from a very large collection of over 300 000 articles were weighted to EMR's contribution to the global research output. We used the mean and standard deviation to summarise the continuous variables and used frequencies and percentages to summarise the categorical variables.
    Results: Biomedical research publication in the EMR increased between 2004 and 2018. Five countries - Islamic Republic of Iran (43%), Egypt (14%), Saudi Arabia (11%), Pakistan (8%), and Tunisia (6%) - contributed 82% of all the publications, while the other countries contributed less than 4%. On average, EMR contributed 2.0% of the global biomedical research publications and 3.12 publications per 100 000 population for 2004-2018.
    Conclusion: Biomedical and health research publication increased unevenly across the EMR countries during the study period. Considering the complexity of the public health challenges in the region, there is a need for multidisciplinary and holistic approaches to health research to generate evidence for policy and to improve clinical and public health outcomes.
    Keywords:  Eastern Mediterranean Region; PubMed; biomedical research; global research output; health research; publications
    DOI:  https://doi.org/10.26719/2024.30.6.414
  106. J Med Imaging Radiat Oncol. 2024 Nov 11.
       INTRODUCTION: The purpose of this work was to determine the current publication output of Royal Australian and New Zealand College of Radiologists radiation oncologists (ROs) to serve as a baseline contributing to future assessment of the effectiveness of the College's Research Action Plan 2024-26.
    METHODS: An online survey was sent to all ROs in the College's member database in March-April 2024 requesting a list of publications between 2022 and 2023. A PubMed search was performed to cross-check the self-reported publications. Given the low response rate (8%), an additional PubMed search was performed for the non-responders. The primary outcomes were publication proportions and rates, and the secondary outcomes were demographic correlates (gender, country, seniority).
    RESULTS: There were 536 eligible ROs (56% males; 80% practicing in Australia; median 12.4 years post-Fellowship) with 1,012 unique publications identified. The proportions of ROs with at least one publication in any-, first- and last-author positions averaged 45%, 15% and 17% per year, respectively. On multivariable analysis, there were statistically significant differences in publications by seniority (higher proportions of last-authorships but lower proportions of first-authorships, for those ≥5 years post-Fellowship) and by country (lower any-, and last-authorships for New Zealand [NZ] than Australia or Singapore). The mean numbers of any-, first- and last-authorships were 1.6, 0.18 and 0.29 per RO per year, respectively. On multivariable analysis, there were statistically significant differences by gender (males had more any-, and first-authorships), seniority (senior ROs had more last-authorships but less first-authorships) and country (lower numbers of any-, and last-authorships for New Zealand).
    CONCLUSION: This organization-wide study provides comprehensive baseline RO publication data and identifies opportunities for the College to further address correlated disparities.
    Keywords:  PubMed search; RANZCR; publication output; radiation oncology; survey
    DOI:  https://doi.org/10.1111/1754-9485.13807
  107. Pediatr Blood Cancer. 2024 Nov 07. e31413
       BACKGROUND: Research expands knowledge and improves outcomes. Research is needed in all settings, but most often occurs in high-income countries (HIC) compared to low- and middle-income countries (LMICs). Publication in scientific peer-reviewed journals and authorship position are important for academic/clinical advancement. We explored the current state of global authorship and data source distribution for publications in the Pediatric Blood and Cancer (PBC) journal.
    PROCEDURE: LMIC-affiliated author inclusion and position in selected article categories of the PBC (2011-2021) were recorded. Articles with at least one LMIC-affiliated author (first-listed affiliation) and 5% of exclusively HIC-authored articles were verified. Descriptive statistical analysis was performed.
    RESULTS: Of 4504 articles reviewed, 593 (13%) included at least one LMIC-affiliated author (517/593 [87%] as first author and 488/593 [82%]) as senior author. In a subset of articles with LMIC-sourced data, 148/675 (22%) included exclusively HIC authors. Within the LMIC-sourced data subset, 81/675 (12%) articles were mixed HIC/LMIC affiliation and 446/675 (66%) were exclusively LMIC-affiliated. The frequency of LMIC-affiliated authors as first or senior author within HIC/LMIC-affiliated collaborations was 31/81 (38%) and 9/81 (11%), respectively.
    CONCLUSION: As more than 80% of children live in LMICs and the WHO Global Initiative for Childhood Cancer is increasingly engaged across LMICs, all researchers/clinicians must justly be given an opportunity to conduct, write, publish, and be recognized for their research. PBC is uniquely poised to promote equitable publishing practices and opportunities for professional recognition by drawing on emerging best practices for equitable authorship, including potentially restructuring authorship guidelines and requirements.
    Keywords:  authorship; authorship guidelines; childhood cancer; equity; low‐ and middle‐income countries; pediatric oncology
    DOI:  https://doi.org/10.1002/pbc.31413
  108. Transl Pediatr. 2024 Oct 01. 13(10): 1858-1869
       Background: Respiratory syncytial virus (RSV) puts children and elderly individuals worldwide at risk for severe health issues and financial difficulties. Prevention is the main treatment for RSV infection, as there is currently no particular therapy. By using bibliometrics analysis, this study attempted to map the increasing tendency in the prevention of RSV infection from January 1991 to August 2024 and to examine the frontiers and hotspots of related research.
    Methods: We extracted pertinent articles through the Web of Science Core Collection (WoSCC) on August 26, 2024, covering the period between January 1991 and August 2024. Then, an online bibliometrix interface (https://bibliometrics.com), R software (version 4.3.2), CiteSpace V6.1R6 (64-bit) software, and the Online Analysis Platform of Literature Metrology were used to analyze the data.
    Results: A total of 709 eligible data points pertaining to the prevention of RSV were included. The United States, England, and the Netherlands were the three major contributors to this field. The most productive journal was Vaccine. Centers for Disease Control and Prevention ranked first, with 22 publications in this field. The fusion (F) protein, nonstructural (NS) protein and glycoprotein (G) protein are the target proteins of RSV prevention drugs.
    Conclusions: In the past 30 years, the research on RSV prevention has entered a stage of rapid development, and many vaccines and monoclonal antibodies have entered the clinical research stage, and some have been marketed.
    Keywords:  Respiratory syncytial virus (RSV); monoclonal antibody; prevention; vaccine
    DOI:  https://doi.org/10.21037/tp-24-271
  109. Arthrosc Sports Med Rehabil. 2024 Oct;6(5): 100969
       Purpose: To determine the prevalence of spin in systematic reviews (SRs) and meta-analyses of clinical studies of the remplissage procedure.
    Methods: Two reviewers independently performed a literature search of the PubMed, Scopus, and Embase databases using the search term "remplissage" in accordance with Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. The full article of each included SR was assessed for the presence of the 15 most common types of spin. Methodologic quality was assessed using the second version of A Measurement Tool to Assess Systematic Reviews (AMSTAR 2).
    Results: A total of 15 SRs (8 accompanied by meta-analyses; 6 Level III and 9 Level IV) were included. Overall, 13 SRs (86.7%) contained at least 1 form of spin, with 33 unique instances of spin recorded; the mean frequency was 2.2 ± 1.3 (range, 0-4). The most prevalent form of spin, present in 11 studies (73%), was type 9 ("conclusion claims the beneficial effect of the experimental treatment despite reporting bias"). There were 14 uses of spin classified as misleading reporting, 16 classified as misleading interpretation, and 3 classified as inappropriate extrapolation. The mean 5-year impact factor of the publishing journals was 4.4 ± 0.9 (range, 0-6.1), the mean number of citations per SR was 33.3 ± 24.9 (range, 0-55), and the mean number of citations per month since publication was 0.68 ± 0.44 (range, 0-1.48). According to the AMSTAR 2 assessment, confidence in the results of the SRs was rated as critically low for 20% of reviews, low for 33.3%, and moderate for 46.7%.
    Conclusions: Most SRs of the remplissage procedure are affected by the presence of spin. Favorable reporting was observed in the absence of definite findings, as was minimization of drawbacks for certain populations.
    Level of Evidence: Level IV, systematic review of Level III and IV studies.
    DOI:  https://doi.org/10.1016/j.asmr.2024.100969