bims-evares Biomed News
on Evaluation of research
Issue of 2024–11–03
79 papers selected by
Thomas Krichel, Open Library Society



  1. Aesthetic Plast Surg. 2024 Oct 25.
       BACKGROUND: Despite the important role of the Aesthetic Plastic Surgery (APS) journal in the field of aesthetic plastic surgery, there is a notable absence of literature that focuses exclusively on the bibliometric analysis of this journal. In recognition of APS's 48 years of publishing, this study aims to perform a bibliometric analysis of the articles published in the APS (1976-2023).
    METHODS: Articles published in the APS were extracted from the Web of Science Core Collection database. VOSviewer was employed to perform bibliometric analyses. Microsoft Excel was utilized to analyse the publication and citation trends.
    RESULTS: From 1976 to 2023, 5134 articles were published in the APS. These articles were contributed by 12,963 researchers from 3354 institutions across 91 countries. The USA and China were the leading contributors. The most prolific author is Luan Jie from China. The co-citation networks highlighted the influence of the journal Plastic and Reconstructive Surgery. We categorized the articles into four groups, and the results show that articles with the highest publications and citations in the APS are related to facial cosmetic surgery. In terms of specific surgical procedures, breast augmentation surgery has garnered consistent attention from researchers over the past 48 years, ranking first in both the number of publications and citations.
    CONCLUSION: The findings of this study indicate that the APS is a significant scientific journal, is widely utilized by global researchers in the field of aesthetic plastic surgery, and spans diverse knowledge domains.
    LEVEL OF EVIDENCE V: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
    Keywords:  Aesthetic Plastic Surgery journal; Bibliometric analysis; VOSviewer
    DOI:  https://doi.org/10.1007/s00266-024-04456-6
  2. Turk J Ophthalmol. 2024 Oct 25. 54(5): 282-290
       Objectives: To conduct the first bibliometric analysis of retinoblastoma research in Türkiye and identify leading institutions, authors, collaboration patterns, and potential growth areas.
    Materials and Methods: We conducted a search on international databases (Web of Science [WoS] and Scopus), a national database (TR Dizin), and gray literature sources (thesis/Scientific and Technological Research Council of Türkiye project reports). Data were cleaned and analyzed using bibliometric tools, including Open Refine and VOSviewer. Bibliometric indicators such as number of publications, journals, h-index, collaboration patterns, and co-occurrence of keywords were examined.
    Results: A search of WoS and Scopus entries published between 1966 and 2024 yielded 122 relevant publications, with articles (n=78, 63.9%) being the most common document type. More than two-thirds of the publications were from 4 institutions: İstanbul University (n=48, 23.8%), Hacettepe University (n=34, 16.8%), Ankara University (n=33, 16.3%), and İstanbul University-Cerrahpaşa (n=22, 10.9%). The total number of citations was 1,148, with an average of 10.16 per publication and an h-index of 16. Excluding 8 internationally collaborated articles, the citations and h-index decreased to 661 and 14, respectively. Pediatric Blood & Cancer was the most preferred journal, with 22 publications (19.5%). The national database search yielded 18 publications with 0 citations. Of 29 relevant theses, only 4 (13.8%) were published. The estimated publication growth predicted an increase in publication numbers per year until 2030.
    Conclusion: This study represents the first bibliometric analysis of retinoblastoma research conducted in Türkiye. Our findings underscore the concentration of research in a few institutions, the importance of international collaborations, and the potential for growth in particular areas. Addressing these areas strategically can empower Turkish researchers to enhance their contributions to the field and improve patient care.
    Keywords:  Bibliometrics; Türkiye; retinoblastoma
    DOI:  https://doi.org/10.4274/tjo.galenos.2024.43247
  3. Clin Ophthalmol. 2024 ;18 2985-2997
       Objective: To explore the research hotspots in acupuncture treatment for myopia from 2014 to 2023.
    Methods: A comprehensive search was conducted in the Science Citation Index-Expanded (SCI-E) within the Web of Science Core Collection (WOSCC). We used CiteSpace 6.2.R6 to perform an in-depth analysis of the annual publication trends, prolific authors, institutions, keyword co-occurrences, and citation bursts. The study followed the PICO framework: the population (P) includes studies on patients with myopia, the intervention (I) is acupuncture treatment, no direct comparison (C) is applied, and the primary outcome (O) focuses on the identification of research trends and hotspots. Major outcome assessments included the analysis of publication trends over time, author productivity, influential journals, and the detection of emerging research topics through citation burst analysis. This bibliometric analysis was conducted on November 15, 2023.
    Results: A total of 281 articles were included in the analysis. The trend line of annual publications over the past decade showed a modest increase, with a significant decline in 2019 and a surge in 2021. China and its affiliated academic institutions led globally in publication volume, with Ma Xiaopeng being the most prolific author and Fudan University the most influential institution. Ophthalmology emerged as the journal with the highest citation frequency. The most frequently occurring keywords were related to adolescent myopia and its complications. The developmental trajectory of the field is distinct, characterized by the integration of a single discipline.
    Conclusion: Acupuncture shows promise as a complementary and alternative therapy for treating myopia, with growing interest in its clinical efficacy and mechanisms of action. Future research is likely to focus on optimizing treatment protocols and understanding the underlying biological mechanisms of acupuncture in myopia management.
    Keywords:  acupuncture; bibliometric analysis; myopia
    DOI:  https://doi.org/10.2147/OPTH.S483740
  4. Front Genet. 2024 ;15 1461386
       Purpose: To highlight the trends and frontiers of RNA methylation in cancer over the past 10 years.
    Methods: Research publications on RNA methylation in cancer were retrieved from the Web of Science Core Collection database. VOSviewer, CiteSpace, and Bibliometrix were used to conduct bibliometric and visualization analysis of countries, institutions, authors, journals, and keywords relevant to this field.
    Results: From 2014 to 2023, research on RNA methylation in cancer has developed rapidly, with an overall increase in the number of publications and citations. China (4320 papers, 115056citations), Sun Yat Sen University (274 papers, 15698 citations), and Zhang, Wei (48 papers, 893 citations) are respectively the countries, institutions, and authors with the highest number of published papers and citations. Frontiers in Oncology (182 papers, 2524 citations) and Molecular Cancer (69 papers, 9224 citations) are the journals with the highest number of published papers and citations in this field, respectively. Co-occurrence analysis of keywords indicates that the research topics can be divided into five clusters: Cluster one: The Role of RNA Methylation in Tumor Heterogeneity, Therapeutic Response, and Prognosis; Cluster two: The Role of Noncoding RNA in RNA Methylation and Tumors; Cluster three: Potential Therapeutic Targets of RNA Methylation in Tumors; Cluster four: The role of RNA methylation in tumor progression and metastasis: A case study of hepatocellular carcinoma and gastric cancer; Cluster five: Regulation mechanisms of m6A methylation in leukemia cell differentiation and tumorigenesis.
    Conclusion: This is the first comprehensive study using bibliometrics to analyze the trends and frontiers of RNA methylation in cancer over the past 10 years, pointing out promising research directions for the future and providing valuable references for researchers in this field.
    Keywords:  RNA methylation; bibliometric analysis; cancer; m6A; noncoding RNA
    DOI:  https://doi.org/10.3389/fgene.2024.1461386
  5. Dent Med Probl. 2024 Sep-Oct;61(5):61(5): 783-795
      Over the last few years, considerable attention has been devoted to glass fiber-reinforced composites (GFRCs) in the field of dentistry. Glass fiber-reinforced composites are useful in prosthodontics, endodontics, restorative dentistry, orthodontics, and periodontics. This study considered various aspects related to GFRCs to assess the publications and citations on the subject from 1998 to 2022.A bibliometric method of analysis was adopted to conduct the study. The relevant papers published within the established time frame were identified. A document-type filter was applied to retrieve only those results that were peer-reviewed. The most influential authors, journals, institutions, and countries were identified, as indicated by the number of citations, as well as the most frequently used keywords.The findings of the bibliometric analysis revealed that the first article on GFRCs in the context of dentistry was published in 1998. The greatest number of papers on this subject was published in 2011 (n = 51), while the number of citations reached its peak in 2008 (n = 1,546). The University of Turku in Finland published the greatest number of articles, whereas Brazil was the most prolific country, producing the highest number of publications on dental fiber. Researchers from Brazil, Italy and Germany mainly collaborated with researchers from other countries, including the USA and Finland. The analysis revealed that publications of multiple authors were more likely to be cited.Significant advancements have been made in the field of GFRCs, as demonstrated by an increased collaboration amongst different countries, organizations and investigators, which enhanced the development and progression of research related to GFRCs.
    Keywords:  bibliometric analysis; biocompatible materials; dentistry; glass fiber; glass fiber-reinforced polymers
    DOI:  https://doi.org/10.17219/dmp/171803
  6. EJNMMI Rep. 2024 Nov 01. 8(1): 36
       BACKGROUND: Positron emission tomography-magnetic resonance imaging (PET/MR) is a cutting-edge hybrid imaging technology with the potential to revolutionize medical diagnosis. This bibliometric study aims to map the research landscape of PET/MR by analyzing a curated set of Web of Science Core Collection documents from 2011 to 2023.
    METHODS: We conducted a bibliometric analysis to map the research landscape of PET/MR, leveraging a curated dataset of 3,600 documents retrieved from the Web of Science Core Collection spanning the period from 2011 to 2023. We employed quantitative methods to assess the quantity and distribution of PET/MR studies, including patterns of change, research status, and directions. Additionally, we utilized VOSviewer software to conduct keyword co-occurrence analysis, explore collaborative networks among authors and institutions, and identify influential journals in the field.
    RESULTS: Results: The analysis reveals several key insights: (1) a significant increase in the number of PET/MR publications over the past 12 years, highlighting the growing interest and activity in this field; (2) the United States and Germany as the leading countries in terms of research output and collaboration, with a growing presence of other countries such as China; (3) the Journal of Nuclear Medicine and the European Journal of Nuclear Medicine and Molecular Imaging as the most influential journals in the field; (4) a shift in research focus from imaging techniques to clinical applications, with an increasing emphasis on prostate cancer, PSMA, and FDG imaging.
    CONCLUSIONS: This study provides a comprehensive overview of PET/MR research, identifying prominent trends, key researchers, and influential works. Based on these findings, we propose recommendations for future research directions in this rapidly evolving field.
    Keywords:  Bibliometrics; Magnetic resonance imaging; Positron emission tomography
    DOI:  https://doi.org/10.1186/s41824-024-00224-6
  7. Inform Health Soc Care. 2024 Oct 27. 1-19
      Health-seeking behavior represents the actions taken to prevent the disease and promote health. It emphasizes both the illness response and the healthcare utilization driven by perceived threat and effectiveness of the preventive behavior. This study aims to scrutinize the progression of research conducted on health-seeking behavior in high-risk period such as COVID-19 using bibliometric analysis. The bibliometric analysis is performed on Scopus and Web of Science databases. Research articles in the English language were extracted using keywords, such as health-seeking behavior and COVID. Eight hundred twenty-five research articles at the final and early publication stage in the English language were extracted from Scopus and 623 from WoS using the keywords Health Seeking Behavior and COVID. Of these, 259 in Scopus and 109 in WoS were selected for the final study following the authors' eligibility criteria. It analyses the research directions, countries of publications, core journals, leading authors and institutions and important publications followed by research trends in this field. It summarizes the academic interest of the researchers in health-seeking behavior in low- and middle-income countries. The paper informs and directs researchers and policymakers on the state of research in health-seeking behavior during high-health risk periods.
    Keywords:  Bibliometric analysis; COVID-19; health seeking behavior; systematic literature review
    DOI:  https://doi.org/10.1080/17538157.2024.2412563
  8. Immun Inflamm Dis. 2024 Oct;12(10): e70048
       BACKGROUND: Despite numerous studies confirming the association between insulin resistance (IR) and macrophage polarization, there is a lack of bibliometric analysis in this area. Therefore, our objective is to conduct a comprehensive analysis of published literature and identify potential future research trends using bibliometrics.
    METHOD: Publications on the topic of macrophage polarization in IR were gathered from the Web of Science Core Collection database (WoSCC) spanning the years 1999-2023. Bibliometric analysis and visualization were conducted using VOSviewers, CiteSpace, the R package "bibliometrix" and Tableau Public.
    RESULT: A total of 3435 articles published between 1999 and 2023 were included in the analysis. These articles originated from 75 countries, with the United States and China leading in contributions. The top five research institutions are the University of California, San Diego, Harvard University, the University of Michigan, Shanghai Jiao Tong University, and Huazhong University of Science and Technology. In this research domain, Diabetes is the most frequently published journal, and the Journal of Clinical Investigation is the most co-cited. Among the 19,398 authors contributing to these publications, Lumeng CN. not only authored the most papers but also received the highest number of co-citations. "Insulin resistance" emerges as a primary keyword in the analysis of emerging research hotspots.
    CONCLUSION: For the first time, bibliometric methods have been employed to conduct a comprehensive summary of papers relevant to macrophage polarization in IR. This study aims to identify the current research direction and future research hotspots, offering valuable guidance and insights for scholars in the field.
    Keywords:  CiteSpace; bibliometric analysis; insulin resistance; macrophage polarize; research hotspots
    DOI:  https://doi.org/10.1002/iid3.70048
  9. Medicine (Baltimore). 2024 Oct 25. 103(43): e40274
       BACKGROUND: Macrophages are key regulators of the inflammatory and innate immune responses. Researchers have shown that aberrant expression of macrophages contributes to the development of abdominal aortic aneurysms (AAA). However, a comprehensive bibliometric analysis exploring the research status and knowledge mapping of this area is lacking. This study aimed to explore the research status, knowledge mapping and hotspots of macrophages in AAA research from a bibliometric perspective.
    METHODS: In this study, we retrieved articles published between 2000 and 2022 on macrophages associated with AAA research from the Web of Science Core Collection (WoSCC) database. The retrieved literature data were further analyzed using Citespace and VOSviewer software.
    RESULTS: A total of 918 qualified publications related to AAA-associated macrophages were retrieved. The number of publications in this field has been increasing annually. China and the United States were the 2 main drivers in this field, contributing to more than 64% of the publications. In addition, the US had the most publications, top institutions, and expert researchers, dominating in research on macrophages in AAA. The Harvard University was the most productive institution, with 60 publications. The journal with the most publications was Arteriosclerosis, Thrombosis, and Vascular Biology (86). Daugherty Alan was the most prolific author (28 publications) and he was also the most cited co- author. Furthermore, the exploration of established animal models, macrophage-related inflammatory-microenvironment, macrophage-related immune mechanism, clinical translation and molecular imaging research remained future research directions in this field.
    CONCLUSIONS: Our findings offered new insights for scholars in this field. They will help researchers explore new directions for their work.
    DOI:  https://doi.org/10.1097/MD.0000000000040274
  10. Int Urol Nephrol. 2024 Oct 30.
       BACKGROUND: The kidney, an essential organ of the human body, can suffer pathological damage that can potentially have serious adverse consequences on the human body and even affect life. Furthermore, the majority of kidney-induced illnesses are frequently not readily identifiable in their early stages. Once they have progressed to a more advanced stage, they impact the individual's quality of life and burden the family and broader society. In recent years, to solve this challenge well, the application of machine learning techniques in renal medicine has received much attention from researchers, and many results have been achieved in disease diagnosis and prediction. Nevertheless, studies that have conducted a comprehensive bibliometric analysis of the field have yet to be identified.
    OBJECTIVES: This study employs bibliometric and visualization analyses to assess the progress of the application of machine learning in the renal field and to explore research trends and hotspots in the field.
    METHODS: A search was conducted using the Web of Science Core Collection database, which yielded articles and review articles published from the database's inception to May 12, 2024. The data extracted from these articles and review articles were then analyzed. A bibliometric and visualization analysis was conducted using the VOSviewer, CiteSpace, and Bibliometric (R-Tool of R-Studio) software.
    RESULTS: 2,358 papers were retrieved and analyzed for this topic. From 2013 to 2024, the number of publications and the frequency of citations in the relevant research areas have exhibited a consistent and notable increase annually. The data set comprises 3734 institutions in 91 countries and territories, with 799 journals publishing the results. The total number of authors contributing to the data set is 14,396. China and the United States have the highest number of published papers, with 721 and 525 papers, respectively. Harvard University and the University of California System exert the most significant influence at the institutional level. Regarding authors, Cheungpasitporn, Wisit, and Thongprayoon Charat of the Mayo Clinic organization were the most prolific researchers, with 23 publications each. It is noteworthy that researcher Breiman I had the highest co-citation frequency. The journal with the most published papers was "Scientific Reports," while "PLoS One" had the highest co-citation frequency. In this field of machine learning applied to renal medicine, the article "A Clinically Applicable Approach to Continuous Prediction of Future Acute Kidney Injury" by Tomasev N et al., published in NATURE in 2019, emerged as the most influential article with the highest co-citation frequency. A keyword and reference co-occurrence analysis reveals that current research trends and frontiers in nephrology are the management of patients with renal disease, prediction and diagnosis of renal disease, imaging of renal disease, and development of personalized treatment plans for patients with renal disease. "Acute kidney injury," "chronic kidney disease," and "kidney tumors" are the most discussed diseases in medical research.
    CONCLUSIONS: The field of renal medicine is witnessing a surge in the application of machine learning. On one hand, this study offers a novel perspective on applying machine learning techniques to kidney-related diseases based on bibliometric analysis. This analysis provides a comprehensive overview of the current status and emerging research areas in the field, as well as future trends and frontiers. Conversely, this study furnishes data on collaboration and exchange between countries, regions, institutions, journals, authors, keywords, and reference co-citations. This information can facilitate the advancement of future research endeavors, which aim to enhance interdisciplinary collaboration, optimize data sharing and quality, and further advance the application of machine learning in the renal field.
    Keywords:  Artificial intelligence; Bibliometrics; Machine learning; Renal medicine
    DOI:  https://doi.org/10.1007/s11255-024-04259-3
  11. World J Orthop. 2024 Oct 18. 15(10): 950-964
       BACKGROUND: Postmenopausal osteoporosis (PMOP) is the most common form of primary osteoporosis among women, and the associated pain often drives patients to seek clinical intervention. Numerous studies have highlighted the unique clinical benefits of exercise therapy (ET) in alleviating PMOP-related pain. However, bibliometric analyses examining collaboration, development trends, and research frontiers in the field of ET for PMOP pain remain scarce.
    AIM: To explore the research trends in ET for pain treatment in PMOP patients over the past decade.
    METHODS: All scholarly works were meticulously sourced from the Science Citation Index-Expanded within the prominent Web of Science Core Collection. Utilizing the capabilities of CiteSpace 6.2.R5, we conducted a thorough analysis of publications, authors, frequently cited scholars, contributing nations, institutions, journals of significant citation, comprehensive references, and pivotal keywords. Additionally, our examination explored keyword cooccurrences, detailed timelines, and periods of heightened citation activity. This comprehensive search, from 2014 through 2023, was completed within a single day, on October 11, 2023.
    RESULTS: In total, 2914 articles were ultimately included in the analysis. There was a rapid increase in annual publication output in 2015, followed by stable growth in subsequent years. Boninger, Michael L, is the most prolific author, whereas Ware JE has the most citations. The United States' global influence is significant, surpassing all other nations. The University of California System and Harvard University are the most influential academic institutions. J Bone Joint Surg Am is the most influential journal in this field. "Spinal cord injury" is the keyword that has garnered the most attention from researchers. The developmental pattern in this field is characterized by interdisciplinary fusion, with different disciplines converging to drive progress.
    CONCLUSION: The academic development of the field of ET for pain in PMOP has matured and stabilized. Clinical management and rehabilitation strategies, along with the mechanisms underlying the relationship between ET and bone resorption analgesia, continue to be the current and future focal points of research in this field.
    Keywords:  Bibliometric analysis; CiteSpace; Exercise therapy; Pain; Postmenopausal osteoporosis; Web of Science
    DOI:  https://doi.org/10.5312/wjo.v15.i10.950
  12. Front Cell Infect Microbiol. 2024 ;14 1460570
       Background: This article employs bibliometric methods and visual maps to delineate the research background, collaborative relationships, hotspots, and trends in the study of gut fungi in human diseases and health.
    Methods: Publications related to human gut fungi were retrieved from the Web of Science Core Collection. VOSviewer, CiteSpace, R software and Microsoft Excel were employed to generate visual representations illustrating the contributions made by countries/regions, authors, organizations, and journals. Employing VOSviewer and CiteSpace, we conducted a comprehensive analysis of the retrieved publications, revealing underlying tendencies, research hotspots, and intricate knowledge networks.
    Results: This study analyzed a total of 3,954 publications. The United States ranks first in the number of published papers and has the highest number of citations and h-index. Mostafa S Elshahed is the most prolific author. The University of California System is the institution that published the most papers. Frontiers In Microbiology is the journal with the largest number of publications. Three frequently co-cited references have experienced a citation burst lasting until 2024.
    Conclusion: Advancements in sequencing technologies have intensified research into human gut fungi and their health implications, shifting the research focus from gut fungal infections towards microbiome science. Inflammatory bowel diseases and Candida albicans have emerged as pivotal areas of interest in this endeavor. Through this study, we have gained a deeper insight into global trends and frontier hotspots within this field, thereby enhancing our understanding of the intricate relationship between gut fungi and human health.
    Keywords:  CiteSpace; VOSviewer; bibliometric; fungal microbiota; inflammatory bowel disease
    DOI:  https://doi.org/10.3389/fcimb.2024.1460570
  13. J Parasitol Res. 2024 ;2024 8201097
      Aim: Malaria vaccine is one of the critical areas in tropical health research, considering the success recorded in other vaccine-preventable diseases. This study is aimed at reviewing recent trends in global malaria vaccine research from 2005 to 2022. Method: A validated search strategy was undertaken to identify scientific literature on the malaria vaccine in the Scopus database. Bibliometric indicators identified include a pattern of publication growth and citations over the study period; top authors, countries, funding organizations, and journals; keywords, including different malarial parasite species, and the overall research themes. Result: A total of 6457 documents were found from 2005 to 2022, published in 160 journals/sources in 189 countries/territories. Malaria Journal published the highest number of research outputs (478, 7.4%) within the study period, and the highest number of documents (468, 7.3%) were published in 2021. There were 214,323 total citations, with 33.2 average citations per document and 167 documents' h-index. The United States, United Kingdom, and Australia combined produced more than 60% of the publication output, with most collaboration with African countries such as Kenya. Plasmodium falciparum is the most occurring parasite species keyword (754, 11.7%), with a growing interest in Plasmodium knowlesi (30, 0.5%). Merozoite surface protein, characterization, trials, infant/children, traveler, and research/review were the six themes that emerged from the studies. Conclusion: The last one and half decades have seen a significant increase in malaria vaccine research and citations, mainly targeting vaccine development, safety, and efficacy in Africa. This necessitates more international efforts to improve the vaccines' effectiveness considering different Plasmodium species.
    Keywords:  Plasmodium; bibliometric analysis; citations; malaria vaccine
    DOI:  https://doi.org/10.1155/2024/8201097
  14. Front Nutr. 2024 ;11 1489222
       Background: Over the past 23 years, there has been a thorough analysis of literature concerning nutritional interventions, nutrients, and feeding approaches related to stroke. Furthermore, a scientific knowledge map was established, elucidating the current state of research, examining its development and trends, and offering new research viewpoints for the future. This study aimed to investigate global and emerging research trends in nutritional interventions for stroke from 2000 to 2023 through bibliometric analysis.
    Methods: A bibliometric analysis of literature from the Core Collection of Scientific Networks for the years 2000-2022 was conducted. CiteSpace, VOSviewer, and bibliometric graphical software were used to identify major contributors to publications, including authors, countries, institutions, journals, references, and keywords.
    Results: The bibliometric analysis yielded a total of 464 publications. This is a gradually increasing number in terms of the number of publications during the study period. China had the highest number of publications. Clinical Nutrition" was the journal with the highest number of relevant publications, and the most commonly used keywords were "stroke," "nutrition" and "malnutrition."
    Conclusion: These analyses reveal research trends in nutritional therapy for stroke from 2000 to 2023 and point to prospective research frontiers. This study provides a deeper understanding of what nutritional treatment of stroke entails and provides guidance and support for future research in this area.
    Keywords:  analysis of references; bibliometry; global trends; nutrition; stroke
    DOI:  https://doi.org/10.3389/fnut.2024.1489222
  15. Adv Ophthalmol Pract Res. 2024 Nov-Dec;4(4):4(4): 209-215
       Objective: This study aims to identify research trends and hot spots in the treatment of Squamous Cell Carcinoma (SCC) over the past decade using bibliometric analysis.
    Methods: Data were extracted from the Web of Science Core Collection, including Science Citation Index Expanded (SCI-Expanded), Social Sciences Citation Index (SSCI), and Emerging Sources Citation Index (ESCI). The data underwent manual cleaning to remove inaccuracies and irrelevancies, followed by transformation into an analyzable format via the VOSviewer software. This tool facilitated the visualization of co-occurrence networks and keyword maps, highlighting the relationships and the prominence of research themes.
    Results: A total of 46448 authors from 7374 institutions across 108 countries contributed to the literature, reflecting a broad international effort. The study documented a consistent increase in SCC-related publications up to 2020, with some variability in subsequent years. Notably, the United States, Germany, China, the United Kingdom, and France were predominant in this research area. The University of Texas MD Anderson Cancer Center and the University of Pittsburgh were leading contributors in terms of publication volume and citation impact. Key journals included 'Oral Oncology' and 'Clinical Cancer Research', which were central to the dissemination of high-impact research. Our keyword analysis identified three major research clusters focused on molecular mechanisms, clinical treatment strategies, and emerging interests in immunotherapeutic approaches.
    Conclusions: The extensive collaboration and the increasing publication trend underscore the growing global commitment to advancing SCC treatment. The high level of engagement from top institutions and the concentration of research in influential journals reflect the field's dynamic evolution towards innovative and effective treatment modalities. This study provides a valuable overview for researchers, guiding future studies towards areas of high impact and emerging trends in SCC treatment. The findings advocate for enhanced focus on personalized medicine and combination therapies, which are poised to improve outcomes for SCC patients.
    Keywords:  Bibliometric analysis; Squamous cell carcinoma; Treatment
    DOI:  https://doi.org/10.1016/j.aopr.2024.08.001
  16. Front Oncol. 2024 ;14 1424044
       Background: An increasing number of studies have turned their lens to the application of Artificial Intelligence (AI) in the diagnosis and treatment of colorectal cancer (CRC).
    Objective: To clarify and visualize the basic situation, research hotspots, and development trends of AI in the diagnosis and treatment of CRC, and provide clues for research in the future.
    Methods: On January 31, 2024, the Web of Science Core Collection (WoSCC) database was searched to screen and export the relevant research published during 2004-2023, and Cite Space, VoSviewer, Bibliometrix were used to visualize the number of publications, countries (regions), institutions, journals, authors, citations, keywords, etc.
    Results: A total of 2715 pieces of literature were included. The number of publications grew slowly until the end of 2016, but rapidly after 2017, till to the peak of 798 in 2023. A total of 92 countries, 3997 organizations, and 15,667 authors were involved in this research. Chinese scholars released the highest number of publications, and the U.S. contributed the highest number of total citations. As to authors, MORI, YUICHI had the highest number of publications, and WANG, PU had the highest number of total citations. According to the analysis of citations and keywords, the current research hotspots are mainly related to "Colonoscopy", "Polyp Segmentation", "Digital Pathology", "Radiomics", "prognosis".
    Conclusion: Research on the application of AI in the diagnosis and treatment of CRC has made significant progress and is flourishing across the world. Current research hotspots include AI-assisted early screening and diagnosis, pathology, and staging, and prognosis assessment, and future research is predicted to put weight on multimodal data fusion, personalized treatment, and drug development.
    Keywords:  Artificial Intelligence; Bibliometrix; CiteSpace; VOSviewer; bibliometrics; colorectal cancer
    DOI:  https://doi.org/10.3389/fonc.2024.1424044
  17. Hum Genomics. 2024 Oct 29. 18(1): 117
       BACKGROUND: Substantial evidence indicates that measuring leukocyte telomere length (LTL) is a useful tool that may be considered as a valuable biomarker of individual biological age, correlating with numerous chronic disorders. However, to date, there has been a lack of in-depth understanding regarding the current landscape and forthcoming developments in the LTL field. Therefore, this study aimed to utilize bibliometric methods to summarize the knowledge structure, current focus, and emerging directions in this field.
    METHOD: Scientific publications on LTL spanning the period from 2000 to 2022 were acquired from the Web of Science Core Collection database. Several bibliometric tools including CiteSpace, VOSviewer, and an online website were utilized for bibliometric analysis. The primary evaluations encompassed investigating the major contributors and their collaborative relationships among countries/regions, institutions, and authors, conducting co-citation analyses of authors, journals, as well as reference, examining reference bursts, as well as performing co-occurrence analyses of keywords.
    RESULTS: There are 1818 papers with 66,668 citations identified. Both the annual publication and citation counts on LTL exhibited significant upward trends. The United States emerged as the most prominent contributor, as evidenced by the greatest volume of papers and the highest H-index value. University of California San Francisco and Aviv A were identified as the most productive institution and author in this domain, respectively. Reference analysis revealed that longitudinal study and mendelian randomization study are the most concerned research method in this field recently. Keywords analysis showed that the most concerned diseases in LTL fields were aging, inflammation, cardiovascular diseases, endocrine diseases, neurological and psychiatric diseases, and cancers. In addition, the following research directions such as "COPD", "mendelian randomization", "adiposity", "colorectal cancer", "National Health and Nutrition Examination Survey (NHNES)", "telomerase reverse transcriptase", "pregnancy" have garnered increasing attention in recent times and hold the potential to evolve into research foci in the foreseeable future.
    CONCLUSION: This is the first bibliometric study that provides comprehensive overview of LTL research. The findings of this study could become valuable references for investigators to explore and address the current and emerging challenges in LTL research.
    Keywords:  Bibliometrics; CiteSpace; Emerging trends; Knowledge landscapes; Leukocyte telomere length; VOSviewer
    DOI:  https://doi.org/10.1186/s40246-024-00687-5
  18. Endocr Metab Immune Disord Drug Targets. 2024 Oct 28.
       BACKGROUND: The ketogenic diet, known for its high-fat, low-carbohydrate composition, has been extensively studied in endocrine and metabolic diseases. This study carried out bibliometric analysis to examine the research trends in this field over the past 20 years, aiming to provide insights for future studies.
    METHODS: We searched the Web of Science Core Collection for all relevant papers. VOSviewer was used for network visualization, the bibliometrix package of R software (version 4.3.0) was utilized for data analysis, and CiteSpace was employed for mapping and trend analysis.
    RESULTS: This study encompassed 508 relevant articles spanning from 2003 to 2023, authored by 2827 researchers from 887 institutions across 57 countries/regions. The total number of publications increased from 3 in 2003 to 508 in 2023, showing a steady growth trend. The United States emerged as the predominant contributor in this field, followed by Italy and China. Notably, SAJOUX I consistently exhibited high activity in this field, according to the analysis, with an h-index of 13. The journal Nutrients has consistently made substantial contributions to this field, accounting for 19% of all publications. The keywords "obesity," "ketogenic diet," and "weight loss" appeared most frequently, with "obesity" occurring 163 times.
    CONCLUSION: This study used a bibliometric method to analyze the impact of the ketogenic diet on the endocrine metabolic system. The research identifies recent frontiers and trending directions, providing valuable references for scholars in this field.
    Keywords:  3-β-hydroxybutyrate; CiteSpace; Ketogenic diet; VOSviewer; bibliometric; endocrine and metabolic diseases
    DOI:  https://doi.org/10.2174/0118715303317289240820114329
  19. Medicine (Baltimore). 2024 Oct 25. 103(43): e39710
       BACKGROUND: Recently, magnetic resonance imaging (MRI) has emerged as a leading technique for investigating schizophrenia (SZ) pathological mechanisms, prompting an increase in related studies. This study aims to examine the field's research status and trends via bibliometric analysis.
    METHOD: The publications on SZ and MRI over the past decade were retrieved from the Web of Science Core Collection (WOSCC) On October 15, 2023. CiteSpace and VOSviewer were used to conduct scientometric and visualized analysis, covering countries, institutions, authors, journals, co-cited literature, and keywords.
    RESULTS: A total of 4840 publications were retrieved from 2014 to 2023. The United States leads with 1863 articles, followed by China with 1127 articles. King's College London had the highest number of publications, with 332 articles. Schizophrenia Research ranks first in the journal that published the research on schizophrenia and MRI, the most published journal, Neuroimage is the most cited journal. Calhoun is the most prolific author with 145 articles, and Fischl is the most cited author, receiving 1188 citations. The literature co-citation network (2014 to 2023) revealed 16 clusters with robust structure (Q = 0.8719) and high confidence (S = 0.9421) involving MRI studies of SZ, genetic imaging and treatment of schizophrenia. Keywords include MRI, psychosis and functional magnetic resonance imaging (fMRI), MRI and neuroimaging, MRI and neuroimaging and white matter and diffusion tensor imaging.
    CONCLUSION: This study offers an overview of the research status and trends of publications on SZ and MRI, aiming to inspire future research directions.
    DOI:  https://doi.org/10.1097/MD.0000000000039710
  20. Front Aging Neurosci. 2024 ;16 1413074
       Background: Deep Brain Stimulation (DBS) has been widely applied and accepted in the treatment of neurological and psychiatric disorders. Despite numerous studies exploring the effects of DBS on the progression of neurodegenerative diseases and the treatment of advanced Parkinson's disease (PD), there is a limited number of articles summarizing this research. The purpose of this study is to investigate the current trends, hot topics, and potential in research surrounding DBS therapy for PD, as well as to anticipate the challenges of such research.
    Methods: We searched the Web of Science Core Collection database (WoSCC) for DBS research literature related to PD published from January 2014 to January 2024, utilized CiteSpace, VOS viewer, the bibliometric online analysis platform, Scimago Graphica, Microsoft Excel 2021, and R software version 4.2.3 for data analysis. And we conducted quantitative research on publications, citations, journals, authors, countries, institutions, keywords, and references, visualized the results in network graphs.
    Results: From 2014 to 2024, papers from 39 journals from 11 countries were among the top 100 cited. Most papers were published in Neurology, with the highest average citations per paper in Nature Neuroscience. The United States (US) contributed the most publications, followed by the United Kingdom (UK) and Germany. In terms of total publications, University College London (UCL) contributed the most papers. The primary classifications of articles were Clinical Neurology, Neurosciences, and Surgery. The top five keywords were subthalamic nucleus, DBS, PD, medical therapy, and basal ganglia. Cluster analysis indicates that DBS research focus on improving quality of life and applying computational models.
    Conclusion: Through bibliometric analysis, researchers could quickly and clearly understand the hotspots and boundaries of their research field, thus guiding their research direction and scope to improve research efficiency and the quality of outcomes. Although studies indicate that DBS is currently a crucial method for treating advanced PD, in the long run, creating a personalized, low-cost treatment regimen with precise targeting and long-term efficacy poses a challenge.
    Keywords:  Parkinson’s disease; bibliometrics; deep brain stimulation; research trends; top-cited; visualized study
    DOI:  https://doi.org/10.3389/fnagi.2024.1413074
  21. World Neurosurg. 2024 Oct 29. pii: S1878-8750(24)01787-X. [Epub ahead of print]
       OBJECTIVE: The aim of this study is to evaluate the 100 most highly cited articles assessing posterior communicating artery aneurysms (PComAA).
    METHODS: In May 2024, a comprehensive search was conducted in the Scopus database using the keyword "posterior communicating artery aneurysm". The top 100 most impactful articles were ranked by citation count and analyzed for relevant factors. Citations per year (CY) was calculated to minimize the risk of bias. Google Scholar (GS) and Web of Science (WOS) citations were also included.
    RESULTS: The top 100 articles were published between 1978 and 2022, with a total of 2935 citations in Scopus, 3988 in GS and 2508 in WOS. The mean number of citations was 29.4 (range 12-158) on scopus, 40.7 (range 10-216) on GS and 26.9 (range 9-120) on WOS. The most contributing country was the United States, while the leading institution was the Second Military Medical University in China. The most productive journal was World Neurosurgery, producing 15 articles. The most prolific author was Liu J.-M with 10 published articles. The funding body with the most funded publication was the National Natural Science Foundation of China. Subcategory analysis revealed that the majority of articles focused on treatment options and post-surgical outcomes, oculomotor nerve palsy, and clinical features.
    CONCLUSION: This study offers a detailed overview of the most cited articles on PComAAs. It demonstrates key contributions made by different countries, institutions, journals, and authors, providing a valuable framework for understanding the evidence supporting the management of these aneurysms.
    Keywords:  Bibliometric; Citation Analysis; oculomotor nerve palsy; posterior communicating artery aneurysm
    DOI:  https://doi.org/10.1016/j.wneu.2024.10.083
  22. Nutrients. 2024 Oct 15. pii: 3493. [Epub ahead of print]16(20):
       BACKGROUND: Non-communicable diseases (NCDs) represent a global health challenge, accounting for 74% of deaths worldwide. One of the recommended interventions to reduce the risk of NCDs is the implementation of warning labels (WLs) on food products to alert consumers about high levels of undesirable nutrients, such as sugar or saturated fats. We aimed to conduct a bibliometric analysis of scientific literature related to WL policies in food and beverages to evaluate global trends and collaborations.
    METHODS: A bibliometric analysis was performed using the Web of Science Core Collection (WoSCC). Articles published between 1998 and 2023 were retrieved using the search terms "warning labels" AND "food" OR "beverage". Bibliometric indicators, including publication counts, citations, collaborations, and thematic trends, were analyzed using the Bibliometrix package in R and VOSviewer.
    RESULTS: We included 255 articles on WLs. Scientific production increased markedly from 2018 onwards, with over 30 articles published annually from 2018 to 2023. The most cited article, by Taillie et al., focused on the impact of Chile's WL policies. The United States had the largest scientific production, followed by Brazil and Chile. Nutrients was the journal with the most publications on this topic.
    CONCLUSIONS: The growth in WL-related research, particularly in Latin America, reflects the increasing implementation of these policies. These results underscore key collaborations and evolving research themes, from food labeling to broader public health impacts, emphasizing the need for continued evaluation of WL effectiveness.
    Keywords:  bibliometrics; food labeling; noncommunicable diseases; nutrition policy; public health
    DOI:  https://doi.org/10.3390/nu16203493
  23. Digit Health. 2024 Jan-Dec;10:10 20552076241288647
       Objective: In the digital age, eHealth is vital in modern healthcare, impacting medical services and public health. Despite its potential in disease management, a comprehensive bibliometric analysis is lacking. This study utilizes bibliometric methods to explore the evolution of eHealth in disease management from 1999 to 2023, aiming to discern the research status and trends.
    Methods: A literature search was conducted using the Web of Science Core Collection (WOSCC) database. Publications and journals were quantitatively analyzed using Microsoft Office Excel 2023. Country/institution/author collaborations and keyword co-occurrences were analyzed using VOSviewer. CiteSpace was employed to analyze the citation bursts of reference. A global distribution network of publications was constructed and thematic trends were analyzed using R package "bibliometrix."
    Results: The study identified 1763 articles on eHealth in disease management. Since 2011, there has been a notable increase in publications, with the United States (n = 391, 22.08%) and the University of Sydney (n = 60, 3.40%) as leading contributors. High-quality journals primarily publish this research. Globally, 9631 authors contributed, with Chavannes, Niels H being the most prolific (n = 23). Author co-citation analysis indicated Eysenbach, G as the most cited (n = 336). Research currently focuses on developing a comprehensive eHealth framework, optimizing mHealth for chronic diseases, improving eHealth intervention trial reporting, assessing social factors in eHealth literacy, and examining telemedicine's role during the Covid-19 pandemic.
    Conclusion: This study offers a comprehensive overview of eHealth research in disease management. eHealth's potential in disease prevention and treatment is significant. To enhance eHealth's impact, international collaboration, technological innovation, tailored intervention trials, addressing the digital divide, and solving legal and ethical issues are crucial. This study will guide future research endeavors, with the goal of enhancing eHealth's benefits and expanding its accessibility to a wider patient base.
    Keywords:  bibliometric analysis; chronic disease management; disease; eHealth; mHealth
    DOI:  https://doi.org/10.1177/20552076241288647
  24. J Multidiscip Healthc. 2024 ;17 4839-4850
       Objective: To analyze research trends, frontiers, and hot topics in specialty nurse training over the past 20 years, and provide a reference for researchers to understand the current research landscape in this field.
    Methods: Studies from the core collection of Web of Science were used. Furthermore, CiteSpace 6.3 R3 was utilized to analyze information on country, institution, authors, keywords and burst words.
    Results: A total of 296 articles were included in the analysis. The United States had the highest number of articles, and there was limited cooperation between authors and institutions. The research hotspots in this field included "clinical education models for specialist nurses", "APN role training", and "interprofessional education".
    Conclusion: The future research trend is to explore the effective integration of training models suitable for different regions and cultural backgrounds and cross-professional education models. It is suggested that researchers pay attention to the innovation and development of specialized nursing clinical practice under different cultural backgrounds, and strengthen international exchanges and cooperation.
    Keywords:  CiteSpace; bibliometric analysis; data visualization; specialty nurse; train
    DOI:  https://doi.org/10.2147/JMDH.S490597
  25. Front Pharmacol. 2024 ;15 1475244
       Background: Research on placental oxidative stress is pivotal for comprehending pregnancy-related physiological changes and disease mechanisms. Despite recent advancements, a comprehensive review of current status, hotspots, and trends remains challenging. This bibliometric study systematically analyzes the evolution of placental oxidative stress research, offering a reference for future studies.
    Objective: To conduct a comprehensive bibliometric analysis of the literature on placental oxidative stress to identify research hotspots, trends, and key contributors, thereby providing guidance for future research.
    Methods: Relevant data were retrieved from the Web of Science Core Collection database and analyzed using VOSviewer, CiteSpace, and the bibliometrix package. An in-depth analysis of 4,796 publications was conducted, focusing on publication year, country/region, institution, author, journal, references, and keywords. Data collection concluded on 29 April 2024.
    Results: A total of 4,796 papers were retrieved from 1,173 journals, authored by 18,835 researchers from 4,257 institutions across 103 countries/regions. From 1991 to 2023, annual publications on placental oxidative stress increased from 7 to 359. The United States (1,222 publications, 64,158 citations), the University of Cambridge (125 publications, 13,562 citations), and Graham J. Burton (73 publications, 11,182 citations) were the most productive country, institution, and author, respectively. The journal Placenta had the highest number of publications (329) and citations (17,152), followed by the International Journal of Molecular Sciences (122 publications). The most frequent keywords were "oxidative stress," "expression," "pregnancy," "preeclampsia," and "lipid peroxidation." Emerging high-frequency keywords included "gestational diabetes mellitus," "health," "autophagy," "pathophysiology," "infection," "preterm birth," "stem cell," and "inflammation."
    Conclusion: Over the past 3 decades, research has concentrated on oxidative stress processes, antioxidant mechanisms, pregnancy-related diseases, and gene expression regulation. Current research frontiers involve exploring pathophysiology and mechanisms, assessing emerging risk factors and environmental impacts, advancing cell biology and stem cell research, and understanding the complex interactions of inflammation and immune regulation. These studies elucidate the mechanisms of placental oxidative stress, offering essential scientific evidence for future intervention strategies, therapeutic approaches, and public health policies.
    Keywords:  VOSviewer; bibliometrics; citespace; emerging topics; oxidative stress; placenta; research focus
    DOI:  https://doi.org/10.3389/fphar.2024.1475244
  26. Drug Des Devel Ther. 2024 ;18 4681-4692
       Purpose: The adverse effects and drug abuse issues associated with opioid drugs have made finding a safe and effective alternative a focus of research. Oliceridine has attracted attention for its lower adverse reactions, such as respiratory depression and gastrointestinal issues, compared to traditional opioids, and is considered a promising candidate for addressing the current limitations in opioid therapy. This article explored the knowledge structure of oliceridine through bibliometric analysis, highlighting its clinical applications in managing acute pain and its mechanisms that may reduce addiction risk. Our bibliometric analysis highlighted hotspots and trends in oliceridine research, guiding future studies on its safety and efficacy in pain management.
    Methods: This study utilized the Web of Science Core Collection database to search for articles related to oliceridine from 2013 to 2024. Systematic analysis was conducted on publication, country, institution, author, journal, references, and keywords. The software Citespace, Vosviewer, and Bibliometrix were employed to visualize bibliometric analysis.
    Results: From 2013 to 2024, 159 articles on oliceridine were published in 98 journals by 158 institutions from 28 countries. The United States has rapidly developed in this field, providing significant momentum. Keyword clustering analysis revealed that research on oliceridine primarily focused on exploring its molecular and pharmacological mechanisms and conducting clinical studies to evaluate its efficacy and safety in pain management. Analyses of the strongest citation bursts with references and keywords indicated that protein-biased ligands and oliceridine were hotspots. The emergence of divergent views regarding oliceridine's biased agonism will lead to future hotspots focusing on the underlying mechanisms of biased signaling by G protein-coupled receptors and drug design.
    Conclusion: Bibliometric analysis provides insights into the current hotspots and emerging areas of oliceridine, which can guide future research. The widespread attention and clinical application of oliceridine lay a solid foundation for further drug development and clinical trials.
    Keywords:  biased agonism; bibliometrics; oliceridine; opioid receptors
    DOI:  https://doi.org/10.2147/DDDT.S475205
  27. Urolithiasis. 2024 Oct 29. 52(1): 153
      Urolithiasis is the most prevalent benign urological condition, imposing a significant burden on morbidity, disability, and healthcare costs globally. Despite its impact, comprehensive bibliometric analyses of randomized clinical trials (RCTs) related to urolithiasis, which are essential for advancing evidence-based medical practices, are lacking. This study aimed to examine the global research landscape and trends in RCTs focused on urolithiasis. This study used bibliometric techniques to analyze a selection of RCTs on urolithiasis published between 1979 and 2023. VOSviewer software version 1.6.20 was used to visualize international collaborations and perform a keyword analysis of the included articles. The main objective was to identify key research areas and focal points within the field of urolithiasis RCTs. Between 1979 and 2023, a comprehensive search identified 16,716 research articles on urolithiasis. A total of 693 relevant RCTs were found in the Scopus database. The number of publications has significantly increased over time, indicating a strong positive correlation (R² = 0.9303; P < 0.001). China was the top contributor, with 166 publications (23.95%), followed by the United States, with 130 publications (18.76%). Turkey and Iran contributed 44 (6.35%) and 62 (8.95%) publications, respectively. Citation analysis revealed an average of 28.13 citations per article, an h-index of 70, and a total of 19,493 citations. The co-occurrence analysis highlighted current research trends and key topics in urolithiasis RCTs, including 'comparative effectiveness of surgical and laser techniques and patient outcomes', 'medical expulsive therapy (MET) for ureteral calculi and clinical outcomes', 'systematic reviews and meta-analyses of RCTs investigating urolithiasis', and 'dietary interventions and correlations between stone composition and the risk of recurrence.' The bibliometric analysis provides an overview of research on urolithiasis RCTs. It examines global research trends and identifies new developments in the field. Our review identified key research themes, including systematic reviews and meta-analyses, dietary interventions, medical therapy for the expulsion of ureteral stones, and comparisons of surgical techniques-areas that will remain focal points in future research. This bibliometric analysis is an invaluable resource for researchers, clinicians, and policymakers, providing a complete overview of past and present research trends. Informed decision making can be promoted and guided in future research, ultimately improving management and understanding.
    Keywords:  Bibliometric; Randomized clinical trials; Renal calculi; Scopus; Urolithiasis; Visualization
    DOI:  https://doi.org/10.1007/s00240-024-01649-1
  28. Medicine (Baltimore). 2024 Oct 25. 103(43): e40256
       BACKGROUND: This paper aims to perform a bibliometric analysis of research pertaining to the nursing care of infected wounds. It also aims to examine the current focal points and trends in research development. The paper offers research references that may be useful for practitioners interested in related areas.
    METHODS: The Web of Science Core Collection database was queried for publications pertaining to infected wound care. Publication trends and proportions were analyzed using Graphpad Prism v8.0.2. CiteSpace (6.2.4R [64-bit]) and VOSviewer (version 1.6.18) were employed to assess the literature and conduct mapping.
    RESULTS: The Web of Science Core Collection database contains 3868 literature related to wound infection care, including 3327 articles and 541 reviews. The literature concerned 117 countries and territories, 4673 institutions, and 20,161 authors. The growth rate of literature was relatively slow before 2015 and markedly accelerated after 2016. Among them, the United States occupies the absolute dominance in research in this field, publishing 37.25% of the papers, and the United States occupies 8 of the top 10 scientific institutions that publish papers. The University of Harvard has published the largest number of papers. Keyword analysis shows a total of 1125 keywords, and through reference literature and time clustering analysis shows that wound healing, sepsis, spine surgery, postoperative infection, nanocrystalline silver, beta lactamase are the current research hotspots.
    CONCLUSION: The escalating rate of literary expansion since 2016 suggests that this domain is garnering an increasingly significant amount of interest. Minimizing the risk of patient wound infection is crucial in reducing patients' discomfort and facilitating their prompt recovery. The literature analysis presented in this study serves as a valuable resource for comprehending the current state of the subject and identifying the current areas of focus.
    DOI:  https://doi.org/10.1097/MD.0000000000040256
  29. Medicine (Baltimore). 2024 Oct 25. 103(43): e40289
      Bladder cancer (BC) is a significant global health issue with high incidence and mortality rates. MicroRNAs (miRNAs) play a crucial role in regulating gene expression and have been found to be dysregulated in BC. Understanding the role of miRNAs in BC development could lead to targeted therapies and improved patient management. Our study presents a thorough examination of the correlation between BC and miRNA research from 2008 to 2022. With the help of 3 powerful methods, including VOSviewer, Biblioshiny, and CiteSpace software, we analyzed the retrieved documents from "Core Collection databases online" on the Web of Science. In total, 798 articles were extracted from the Web of Science, and the number of published papers showed an upward trend from 2008 to 2019. The total number of citations was 21,233, of which the highest paper was a review article written by Chan Jiajia et al in 2018 with 752 citations. Based on the result of the coauthor analysis, Seki Naohiko was the most productive writer and China had the highest volume of published articles. Co-citation analysis was used to reveal the knowledge structure of the research field. In addition to the keywords "Bladder cancer" and "miRNA," "Proliferation," "Biomarkers," and "Apoptosis" were the high-frequency used keywords. Recently, increasingly researchers have paid more attention to the field about BC and miRNA around the worldwide. Through in-depth communication and close collaboration, the veil of miRNA in BC has gradually been unveiled. Bibliometric analysis helps to identify hotspots in research and areas for future investigation.
    DOI:  https://doi.org/10.1097/MD.0000000000040289
  30. Medicine (Baltimore). 2024 Oct 25. 103(43): e40216
      Research on the use of optical coherence tomography (OCT) in acute coronary syndrome (ACS) has increased in recent years. However, a comprehensive analysis of the trends and hotspots in OCT research is currently lacking. The objective of this study was to identify global trends in research on OCT in ACS from a bibliometric perspective and to provide researchers with new research hotspots. Relevant literature from 1998 to 2023 was retrieved from the Web of Science Core Collection. CiteSpace and VOSviewer software were used to collect and analyze publication trends in related fields. A total of 965 publications from 58 countries and 1389 institutions were included in the present study. We found that Japan produced the most publications (20.83%, 201), followed by the United States (19.90%, 192), and China (14.09%, 136). However, the United States has the highest total number of citations in this field. Harvard Medical School and Harbin Medical University had the highest numbers of publications and citations. The journal with the most publications was the International Journal of Cardiology. Plaque erosion, calcified nodules, and intracoronary imaging are the most recent research hotspots and frontiers. Our work summarizes 25 years of OCT research in the ACS, highlighting hotspots, key themes, and emerging frontiers to help guide future research.
    DOI:  https://doi.org/10.1097/MD.0000000000040216
  31. Medicine (Baltimore). 2024 Oct 25. 103(43): e40261
      Genetic factors play a significant role in the development of congenital heart disease (CHD). Many studies on the genetics of CHD have been published worldwide; however, no research has assessed and mapped the global research landscape of these studies. This bibliometric and visualized study aimed to delineate research hotspots and trends in the field of CHD genetics. Scientific papers on the genetics of CHD from January 1, 1950, to December 31, 2023, were obtained by searching the Web of Science Core Collection. The bibliometric metadata of each chosen research paper were extracted, analyzed, and visualized using tools such as Microsoft Excel 2021, VOSviewer, and CiteSpace. The final analysis included 5317 papers discussing the genetics of CHD. The countries and journals that published the highest number of papers were the United States (n = 2118), and American Journal of Medical Genetics Part A (n = 332), respectively. In addition to CHD and genetics, keywords such as tetralogy of Fallot, ventricular septal defect, and atrial septal defect appeared most frequently among 8365 keywords. Eight clusters were formed to categorize the keywords. Keywords such as case-control study, whole genome sequencing, and whole exome sequencing in clusters 6, 7, and 8, respectively, had the latest average publication year among all clusters. To the best of our knowledge, this is the first bibliometric analysis of CHD genetics studies. Tetralogy of Fallot, ventricular septal defect, and atrial septal defect are global research topics. The interactions between environmental and genetic factors in the pathogenesis of CHD, genetic etiology of CHD-associated pulmonary arterial hypertension, and molecular genetics of CHD via high-throughput genomic technology are possible areas of future research on the genetics of CHD.
    DOI:  https://doi.org/10.1097/MD.0000000000040261
  32. J Robot Surg. 2024 Oct 26. 18(1): 384
       BACKGROUND:  Robotic metabolic and bariatric surgery (RMBS) has emerged as an innovative approach in the treatment of severe obesity by combining the ergonomic precision of robotic technology and instrumentation with the established benefits of weight loss surgery. This study employs a bibliometric approach to identify local research trends and worldwide patterns in RMBS.
    MATERIALS & METHODS:  The research methodology used "robotic" and "metabolic" or "bariatric surgery" to search Web of Science. Articles that were published prior to December 31st, 2023, were included. The analyses were developed using the Rayyan and Bibliometric, in R Studio.
    RESULTS:  265 articles from 51 different journals were included. Scientific production of RMBS experienced a significant annual growth rate of 21.96% from 2003 to 2023, resulting in an average of 12.6 papers published per year. A high correlation (R2 = 0.94) was found between the year and number of articles. The mean number of citations per document was 13.25. Approximately 90% of the journals were classified as zone 3, according to the Bradford categorization. International collaboration was identified in 10.57% of cases, with the University of California and the University of Illinois being the most common organizations. The countries with the highest number of corresponding authors, in descending order, were the United States of America, China, and Switzerland.
    CONCLUSION:  Scientific production in RMBS has experienced sustained growth since the first original publications in 2003. While it has not yet reached the volume, impact, and international collaboration seen in studies related to non-robotic metabolic and bariatric surgery, RBMS holds potential that remains to be explored.
    Keywords:  Bariatric surgery; Bibliometric analysis; Metabolic surgery; Robotic surgery
    DOI:  https://doi.org/10.1007/s11701-024-02135-x
  33. J Neurooncol. 2024 Oct 30.
       PURPOSE: The Journal of Neuro-Oncology (JNO), established in 1983, plays a key role in publishing research on brain and spinal cord tumors. This study examines JNO's publication trends, focusing on country and gender representation to highlight its global impact.
    METHODS: Statistical analyses were conducted using R. Gender of the first authors was predicted using a gender-guesser, and author affiliations were used to determine publication countries. We introduced a novel Country-Related Diversity (CRD) index to assess the JNO's representativeness, comparing a country's JNO publications to its overall neurosurgical output. An index value of 1 indicates proportional representation.
    RESULTS: The JNO corpus, spanning from 1983 to 2024, comprises 8,154 documents with an average document age of 14.4 years. The average citation count per document is 28.71, with a rate of 2.16 citations per document per year. JNO's scientific output has grown significantly, peaking at 397 articles in 2011, with a long-term annual growth rate of 3.7%. The keyword analysis highlights "glioblastoma" as the most frequent term, reflecting the journal's neuro-oncological focus. Geographically, the U.S. led with 2,535 articles (40.1%), followed by China and Germany. International collaboration rose steadily, with multi-country publications increasing from 4.76% in 1983 to 20.98% in 2024. Analyzing contributions from different countries showed a converging CRD index toward 1 (P < 0.01), with U.S. and non-U.S. countries trending similarly. Upper-middle-income countries displayed fluctuating CRD patterns, whereas lower-middle-income countries lagged behind. Authorship analysis showed an increasing trend in co-authorship (P < 0.01), with the average number of authors per paper reaching 10.4 by 2024. Gender representation revealed a growing number of female first and senior authors, although males still dominate. By 2024, 32.9% of first authors and 21.6% of senior authors were female, signaling a gradual trend toward gender parity (P < 0.01).
    CONCLUSIONS: The CRD index offers a standardized measure of country-specific research representation in the JNO. The convergence towards 1 reflects balanced international representation. JNO publication also reflects a trend toward gender equity, with a notable rise in female first authors, enhancing global research inclusivity.
    Keywords:  Country-based representativeness; Gender equity; Journal of neuro-oncology; Publication trend
    DOI:  https://doi.org/10.1007/s11060-024-04869-y
  34. Medicine (Baltimore). 2024 Oct 25. 103(43): e40049
       BACKGROUND: Food addiction is a chronic psychological disorder resulting from repeated consumption of highly palatable foods, leading to physical and mental harm. It involves individuals who struggle to control their intake of high-energy, high-fat, and high-sugar foods, often experiencing withdrawal reactions and intense cravings that trigger binge eating during stress. Recent research has focused on the impact of food addiction on physical health, nutrition, and mental well-being. This study aims to review and analyze current evidence on food addiction to advance research in China.
    METHODS: A total of 941 articles on food addiction published between January 2013 and April 2023 were analyzed using the Web of Science Core Collection. CiteSpace software was utilized to identify research trends, collaborations among disciplines, authors, and institutions, as well as key topics and emerging keywords.
    RESULTS: The number of publications on food addiction has steadily increased over the past decade, with the United States leading in research output (393 articles). The University of Michigan and author Gearhardt AN were prominent contributors. Key research topics included obesity, eating disorders, addiction, and overeating. Emerging themes encompassed obesity psychology, food composition, brain function, and behavioral addiction.
    CONCLUSION: Global research on food addiction primarily focuses on understanding the psychological and neurological underpinnings, metabolic implications, addictive behaviors, and treatment modalities such as sleeve gastrectomy. Future research aims to develop personalized prevention and intervention strategies for food addiction.
    DOI:  https://doi.org/10.1097/MD.0000000000040049
  35. Front Immunol. 2024 ;15 1437570
       Background: Regulated cell death (RCD) is a genetically controlled form of cell death that plays an important role in organogenesis, tissue remodeling, and pathogenesis of cancers. Transforming growth factor-beta-activation kinase 1 (TAK1) is a member of the serine/threonine protein kinase family, which can respond to internal and external stimuli and participate in inflammatory responses through multiple signaling pathways and cellular processes. In the last two decades, the regulatory roles of TAK1 at the crossroads of multiple RCD pathways, including apoptosis, necroptosis, pyroptosis, and PANoptosis were revealed by 801 articles retrieved from the Web of Science Core Collection database. To analyze global research trends and hotspots concerning the role of TAK1 in RCD, the bibliometric and visualized analysis were applied in the current study.
    Methods: The data for this bibliometrics study were retrieved from the Web of Science Core Collection database. The search formula was (TS=(Apoptosis) OR TS=(pyroptosis) OR TS=(Necroptosis) OR TS=(PANoptosis) OR TS=(Autophagy) OR TS=(Ferroptosis) OR TS=(cuproptosis)) AND ((TS=(TAK1)) OR TS=(MAP3K7)). The co-occurrence and co-cited analysis on basic bibliometric parameters were conducted by VOSviewer. The dual-map overlay of journals, citation bursts, keyword timelines, and keyword bursts were analyzed by CiteSpace.
    Results: A total of 801 articles from 46 countries have been included in the analysis. The number of publications demonstrates a consistent increase from 1999 to 2024. The primary research institutions driving this field are Osaka University Notably, the Journal of Biological Chemistry stands out as the most popular journal in this domain. These publications collectively involve contributions from 4663 authors, with Jun Tsuji emerging as a prolific author. Jun Tsuji also gains the highest co-citation frequency. Emerging research hotspots are encapsulated by keywords, including apoptosis, NF-κB, inflammation, autophagy, and TNFα.
    Conclusion: This is the first bibliometric and visualized study to analyze the global trends and hotspots of TAK1 in RCD. Based on the analysis of 801 articles, the results provide a retrospective and comprehensive visualized view of the research hotspots and frontiers of TAK1 at the crossroads of multiple RCD signaling pathways and propose ideas for guiding their future investigations in molecular mechanisms and therapeutic strategies in this field.
    Keywords:  CiteSpace; PANoptosis; TAK1; VOSviewer; bibliometric analysis; cancer; necroptosis; regulated cell death
    DOI:  https://doi.org/10.3389/fimmu.2024.1437570
  36. Autoimmun Rev. 2024 Oct 29. pii: S1568-9972(24)00167-8. [Epub ahead of print] 103676
       INTRODUCTION: Autoimmune/Inflammatory Syndrome Induced by Adjuvants (ASIA) encompasses a spectrum of autoimmune and inflammatory conditions triggered by various adjuvants, leading to significant health challenges. This study aims to understand the research landscape and future directions of ASIA through a comprehensive bibliometric analysis.
    METHODS: Relevant original articles were retrieved from the Scopus database, focusing on publications from 2011 to July 2024. The analysis included evaluating countries/regions, institutions, authors, co-cited references, and keywords using VOSviewer and Biblioshiny software.
    RESULTS: The final analysis incorporated 346 documents contributed by numerous researchers from multiple institutions worldwide. Israel emerged as the leading contributor to ASIA research. The study found that while there are significant international collaborations, certain countries like Israel and Italy play central roles in these networks. Key research areas identified include autoimmunity, adjuvants, vaccines, and silicone. Notable keywords include "ASIA syndrome," "Autoimmunity," "Adjuvants," and "Silicone." The citation analysis highlighted the impactful nature of research from Israel, Italy, and Mexico. In addition, the analysis highlights the growing body of evidence that supports the role of adjuvants in triggering autoimmune responses. Over the years, there has been a significant increase in publications investigating the mechanisms by which adjuvants (such as those used in vaccines, silicone implants, and other medical applications) can activate immune responses, leading to conditions associated with ASIA syndrome.
    CONCLUSION: The field of ASIA research is experiencing rapid growth, characterized by increasing publication activity and robust international collaborations. Future research is likely to focus on the mechanisms underlying ASIA syndrome and improving patient outcomes.
    Keywords:  ASIA syndrome (Autoimmune/inflammatory syndrome induced by adjuvants); Adjuvants; Autoimmunity; Bibliometric analysis; Silicone; Vaccines
    DOI:  https://doi.org/10.1016/j.autrev.2024.103676
  37. Front Oncol. 2024 ;14 1423924
       Background: Breast cancer, particularly triple-negative (TNBC), is a leading malignancy with aggressive traits and high metastasis rates. Clinical trial is an important tool for optimizing therapeutic strategies in the evaluation of the safety and efficacy for TNBC. Our bibliometric study of TNBC clinical trials aims to assess therapeutic strategies, identify trends, and explore advancements in treatment. We focus on mapping knowledge development, including key research entities and topics, and analyzing research trends and emerging methods. This analysis intends to inform future research, especially in personalized and precision medicine for TNBC.
    Methods: We selected publications on clinical trials for the treatment of TNBC from 1997 to 2024 in the Web of Science Core Collection (WoSCC). After an initial screening, we downloaded key data including titles, publication years, authors, countries, institutional affiliations, journals, keywords, and abstracts, and saved them in BibTex format. We then conducted a bibliometric analysis using Bibliometrix in R and VOSviewer to illustrate the prospects, highlights, and trends of TNBC treatment options. Furthermore, to emphasize the hot topics in TNBC treatment strategies, we performed a bibliometric analysis of immunotherapy using the same approach.
    Results: 1907 publications were included, most of which were from China, Italy, and the United States. The number of annual publications has increased dramatically since 2010. The focus of TNBC clinical trial research has shifted from understanding the biology, such as breast cancer subtyping and genotyping, to novel therapeutic approaches. The major advancement in clinical trials is the switch from late-stage palliative treatment to early preoperative neoadjuvant therapy, as more TNBC cases are discovered at an early stage. Immunotherapy is also highlighted with additional alternatives for advanced or metastasized TNBC, such as targeted inhibitors with unusual mutation rates and antibody drug conjugates (ADC).
    Conclusions: This investigation made it apparent how immunotherapy has recently made major advancements in TNBC treatment plans and how ADCs, or targeted therapies, are currently popular for TNBC. By identifying significant papers, comprehending trending topics, and collaborating across multiple disciplines, this study may accelerate research on TNBC therapy options.
    Keywords:  TNBC; antibody drug conjugates; bibliometric analysis; clinical trial; immunotherapy; neoadjuvant therapy
    DOI:  https://doi.org/10.3389/fonc.2024.1423924
  38. Medicine (Baltimore). 2024 Oct 04. 103(40): e40000
       BACKGROUND: Apoptosis, a form of programmed cell death, plays a significant role in osteoarthritis; however, bibliometric studies in this field remain scarce. Bibliometrics provides a visual representation of research outcomes and trends, guiding future investigations.
    METHOD: Journal data from January 1, 2013, to December 31, 2023, in this field were obtained from the Web of Science (WOS) core database. Analysis was conducted using VOSviewer and CiteSpace.
    RESULTS: Analysis revealed that over the past decade, 794 articles were published in 299 journals by 4447 authors from 49 countries and 877 institutions. The top contributors were China, the United States, and the United Kingdom. Zhuang Chao emerged as the most prolific author, and "osteoarthritis and cartilage" ranked as the most frequently cited journal. Keyword clustering focused on mechanisms, inflammation, and cartilage. The most-cited article was "chondrocyte apoptosis in the pathogenesis of osteoarthritis" in the "International Journal of Molecular Sciences." Burst word analysis highlighted extracellular matrix, circular RNA, micro RNA, indicating current research hotspots.
    CONCLUSION: Utilizing bibliometrics and visual analysis, we explored the hotspots and trends in the field of chondrocyte apoptosis in osteoarthritis. Extracellular matrix, Circular RNA, Micro RNA, among others, are likely to become future research focal points and frontiers.
    DOI:  https://doi.org/10.1097/MD.0000000000040000
  39. World J Psychiatry. 2024 Oct 19. 14(10): 1592-1604
       BACKGROUND: Cognitive impairment, which manifests as a limited deterioration of specific functions associated with a particular disease, can lead to a general deterioration of the patient's standard of living. Transcranial magnetic stimulation, a non-invasive neuromodulation technique, is frequently employed to treat cognitive impairment in neuropsychiatric disorders.
    AIM: To analyzed the state of international research on neuromodulation methods for treating cognitive impairment between 2014 and 2023, with the aim of exploring the state of research worldwide and the most recent developments in this particular area.
    METHODS: Articles and reviews pertaining to neuromodulation methods for cognitive impairment were examined using the web of science database between January 2014 and December 2023. Publications, nations, organizations, writers, journals, citations, and keywords data from the identified studies were systematically analyzed using the CiteSpace 6.3. R1 software.
    RESULTS: A total of 2371 documents with 11750 authors and 9461 institutions, with some co-occurrences, were retrieved. The quantity of yearly publications is showing an increasing trend. The United States and China have emerged as important contributors. Among the institutes, Harvard University had the highest number of publications, while Rossi S an author who is frequently cited. Initially, the primary keywords included human motor cortex, placebo-controlled trials, and serotonin reuptake inhibitors. However, the emphasis gradually moved to substance use disorders, supplementary motor areas, neural mechanisms, and exercise.
    CONCLUSION: The use of neuromodulation techniques to treat cognitive impairment has drawn interest from academics all around the world. This study revealed hotspots and new trends in the research of transcranial magnetic stimulation as a cognitive impairment rehabilitation treatment. These findings are hold significant potential to guide further research and thus promote transcranial magnetic stimulation as a treatment method for cognitive impairment.
    Keywords:  Bibliometric analysis; Cognitive impairment; Hotspots; Research trends; Transcranial magnetic stimulation
    DOI:  https://doi.org/10.5498/wjp.v14.i10.1592
  40. Medicine (Baltimore). 2024 Oct 04. 103(40): e39831
       BACKGROUND: Acquired immunodeficiency syndrome is a malignant infectious disease caused by the human immunodeficiency virus (HIV). HIV gradually destroys the body's immune system and weakens the body's ability to resist diseases. People living with HIV may have a higher incidence of coronary heart disease than people without HIV.
    METHOD: A literature retrieval from January 1, 1993 to October 1, 2023 based on the Web of Science Core Collection database. CiteSpace6.2.R4, VOSviewer v1.6.19, and Microsoft Excel 2019 were utilized for analyzing the following terms: countries, institutions, authors, journals, references, and keywords.
    RESULTS: There were 1144 articles. The highest number of articles is in the USA, followed by Italy. University of California System, Harvard University, and Johns Hopkins University were the top 3 most productive institutions with publications in this field of research. Journal of Infectious Diseases ranked first with the highest publications (532 records), followed by Immunology (362 records), and Cardiac Cardiovascular Systems (242 records). Keyword co-occurrence analysis showed antiretroviral therapy, myocardial infarction, and protease inhibitors, etc. Keyword cluster analysis obtained 13 categories, which were roughly divided into 3 themes: (1) cardiovascular disease that has occurred or may occur; (2) HIV acquisitions that have occurred; (3) risk factors for cardiovascular disease.
    CONCLUSION: The article obtained the hotspots and trends and provided references for subsequent research. Based on the keyword citation burst detection analysis, we speculated that heart failure, risk, subclinical atherosclerosis, infection, and association were the research hotspots in recent years, which had a certain predictive effect on the future research direction.
    DOI:  https://doi.org/10.1097/MD.0000000000039831
  41. World J Microbiol Biotechnol. 2024 Oct 26. 40(11): 365
      Macrofungi (or mushrooms) are essential for agriculture, food, and ecology. Although research on the growth and development of macrofungi (GDM) can provide insights into their biological characteristics and metabolite synthesis mechanisms, further exploration is needed for a systematic and visual analysis of the current research progress on GDM. To comprehensively understand the research status and development trend of GDM, a total of 545 scientific literature related to GDM in the Web of Science Core Collection database from 2008 to 2024 were searched and selected as research objects. The general information (publication year, country, institution, and cited journal) and the specific information (co-authorship, keyword co-occurrence, and references with strong citation bursts) were mined and visualized in detail based on CiteSpace software. These analyses demonstrated that related research is still fashionable, and China is dominant and influential in this field. More frequent and in-depth cooperation among authors, institutions and regions is conducive to promoting the research on GDM. Additionally, the quantity and cluster analyses of keywords and references demonstrated that medicinal/edible macrofungi and sustainable development (e.g. mushroom substrate reuse) may be research hotspots and will remain popular in the coming years. This research aims to supply researchers with up-to-date knowledge and cutting-edge issues related to GDM by providing a visually appealing representations on quantitative GDM studies.
    Keywords:  CiteSpace; Development; Mushrooms; Visual analysis; Web of science core collection
    DOI:  https://doi.org/10.1007/s11274-024-04168-8
  42. J Family Med Prim Care. 2024 Sep;13(9): 3608-3613
       Introduction: The Siddha system of medicine (SSM) is one of the Indian Systems of Medicine (ISM). In recent times, it has received adequate support from the Indian Ministry of Ayush. Like many such indigenous systems of medicine globally, the SSM is based on its own theoretical principles, philosophy, and methods of practice. Nevertheless, SSM conducts and needs basic and applied research using scientific methods. Such research is evidenced by research publications. In the absence of a review, we did a bibliometric analysis of research publications from SSM for the period of 1972-2019.
    Materials and Methods: We used the term "Siddha" to retrieve the data from the PubMed database. We retrieved data from the National AYUSH research portal and homepages of institutions mandated to do research in SSM. We abstracted bibliometric information and used Epi info (Version 7.2) for analysis. We described the trends and key characteristics.
    Results: Of a total of 2009 retrieved articles, we included 1457 (73%) for analysis. Between 1972 and 2001, the median number of publications per year was three (range: 0-13). Beyond 2012, the publications increased exponentially with an annual growth of 23%. The maximum number of publications (n = 224) was in 2019. Among 43 countries that produced the papers, India topped it (88%). Of 1457, 1.7% (n = 25) of publications from Siddha institutions were indexed in PubMed.
    Conclusion: A bibliometric review of research output from SSM suggests that the publications have increased in the last two decades. The review recommends improving research output from SSM in terms of quantity and quality.
    Keywords:  Alternative medicine; Ayush; Siddha; scientometrics; traditional medicine
    DOI:  https://doi.org/10.4103/jfmpc.jfmpc_1623_23
  43. Medicine (Baltimore). 2024 Oct 04. 103(40): e39916
      The triglyceride-glucose (TyG) index is a crucial marker of insulin resistance, as evidenced by numerous studies related to metabolic diseases. This bibliometric analysis investigates research trends associated with the TyG index over the past 24 years. We collected data on TyG index publications from January 1, 2000, to January 7, 2024, using the Web of Science database. Analysis was conducted utilizing VOSviewer, Scimago Graphica, and CiteSpace to evaluate publication metrics, citations, countries, institutions, authors, journals, and keywords. A total of 1163 publications from 354 journals authored by 6149 researchers across 60 countries were analyzed. China emerged as the leading contributor, with 654 publications (56.23%). Capital Medical University was the most productive institution, and Wu Shouling was the top author. Cardiovascular Diabetology was identified as the most influential journal. Key emerging research directions include the role of the TyG index as a representative marker for insulin resistance, particularly concerning insulin sensitivity; its association with body mass index and hyperuricemia; and its diagnostic and prognostic value in nonalcoholic fatty liver disease and cardiovascular conditions such as acute coronary syndrome, carotid plaque, and hypertension. Current trends favor cohort studies predominantly involving adult populations. Overall, China leads TyG index research, focusing on its connections to insulin sensitivity, body mass index, and hyperuricemia, while the index's diagnostic and prognostic significance for nonalcoholic fatty liver disease and cardiovascular diseases represents an expanding research frontier.
    DOI:  https://doi.org/10.1097/MD.0000000000039916
  44. Medicine (Baltimore). 2024 Oct 25. 103(43): e40213
       BACKGROUND: Orexin is an excitatory neuropeptide produced in the lateral hypothalamus, playing a role in various physiological functions in humans. There is a growing body of literature on orexins. This paper utilizes CiteSpace software to organize and analyze a significant number of articles on orexin, providing readers with an intuitive overview of research trends and emerging hot topics in this field.
    METHODS: The electronic database, Web of Science Core Collection (WoSCC), was searched for publications related to orexins. Annual publications, countries/regions, institutions, authors and keywords were analyzed, and the results were visualized via CiteSpace software.
    RESULTS: A total of 5486 publications were included, with articles making up 85.30% and reviews 14.70%. The top 3 countries publishing the most papers on orexins were the United States (2057 papers), Japan (778), and China (556). The leading institutions included Research Libraries UK (278), Harvard University (250), and Stanford University (221). The most prolific authors in the field were Yves Dauvilliers (69), Abbas Haghparast (67), and Takeshi Sakurai (66). The most frequently used keywords were "neurons" (981), followed by "sleep" (824), "food intake" (612), "receptors" (547), and "neuropathology" (535). Recent research hotspots include melanin-concentrating hormone neurons, Alzheimer disease, gamma-aminobutyric acid neurons, oxidative stress, suvorexant, the orexin system, prevalence, and stress. Based on keyword clustering analysis, the top 5 research hotspots from 2003 to 2022 were: the effects of orexins on sleep and metabolism, potential pathways of orexin signaling, the relationship between orexin and immunity, new findings on depression and hypertension related to orexin, and possible targets for neurodegenerative diseases.
    CONCLUSION: Orexin, a neuropeptide linked to various physiological and pathological processes, plays a crucial role in sleep/wakefulness, reward mechanisms, stress responses, and neurodegenerative diseases. Its significant research value and potential medical applications are underscored by the rapid expansion of studies, particularly in the USA and Japan. However, the lack of collaboration among researchers highlights the need for enhanced academic exchange and cooperation to further advance the field of orexin research.
    DOI:  https://doi.org/10.1097/MD.0000000000040213
  45. Cureus. 2024 Sep;16(9): e70132
      Quantum dots (QDs) are semiconductor nanoparticles with immense potential accompanied by unique optoelectronic properties for revolutionizing several biomedical applications related to imaging, diagnostics, drug delivery, and therapy. A detailed bibliometric analysis has been performed in this article with regard to research relating to QDs in the health sector during 2004-2024. In spite of their promising applications, assessment of the toxicity of QDs, especially highly toxic heavy metal-based QDs like cadmium, is still the most important apprehension. This analysis identifies from Scopus data key trends, influential authors, leading sources, and significant collaborative networks in the field. On VOSviewer and Biblioshiny, visualization tools are used to show research trends and networks that help in the discovery of critical knowledge about the entire global landscape of research. The increasing scientific interest has been realized in a stable trend with peaks of notable and emerging topics attesting to its dynamism. The study epitomizes how international collaboration can advance the QD applications boundary for healthcare.
    Keywords:  bibliometric analysis; biblioshiny; health; quantum dots; vosviewer
    DOI:  https://doi.org/10.7759/cureus.70132
  46. J Pediatr Nurs. 2024 Oct 30. pii: S0882-5963(24)00385-3. [Epub ahead of print]
       BACKGROUND: Parents of technology-dependent children constitute a different population in society and face diverse problems during caregiving.
    METHODS: This study aimed to identify and visualize studies conducted from 1990 to 2024 on technology-dependent children, home care, and parental discharge education and determine global trends. A descriptive and bibliometric study design was employed. Data were obtained from the Web of Science Core Collection database, and bibliometric analyses were performed with performance analysis, visualization, and mapping using the Biblioshiny interface in the R software. Screening yielded a total of 157 publications. A total of 138 publications were included.
    FINDINGS: The keywords frequently used by the authors included "home care," "technology-dependent children," "palliative care," "home mechanical ventilation," "child," "family," and "pediatric." Co-author keywords with moderate centrality and density are "home mechanical ventilation" (Betw = 106.47), "technology-dependent" (Betw = 106.47), "home mechanical ventilation" (Betw = 106.47). Each article had 4.41 co-authorships, with an international co-authorship rate of 6.52 %.
    CONCLUSIONS: This study provided important data on studies focusing on technology-dependent children, home care, and parental discharge education.
    APPLICATION TO PRACTICE: Since the number of studies in the field is small, the findings of this study are essential in guiding researchers about gaps in the literature.
    Keywords:  Bibliometrics; Home care; Nursing; Parental education; Technology-dependent child
    DOI:  https://doi.org/10.1016/j.pedn.2024.10.024
  47. Semin Ophthalmol. 2024 Oct 26. 1-13
       PURPOSE: The burst of modern information has significantly promoted the development of global medicine into a new era of big data healthcare. Ophthalmology is one of the most prominent medical specialties driven by big data analytics. This study aimed to describe the development status and research hotspots of big data in ophthalmology.
    METHODS: English articles and reviews related to big data in ophthalmology published from January 1, 1999, to April 30, 2024, were retrieved from the Web of Science Core Collection. The relevant information was analyzed and visualized using VOSviewer and CiteSpace software.
    RESULTS: A total of 406 qualified documents were included in the analysis. The annual number of publications on big data in ophthalmology reached a rapidly increasing stage since 2019. The United States (n = 147) led in the number of publications, followed by India (n = 77) and China (n = 69). The L.V. Prasad Eye Institute in India was the most productive institution (n = 50), and Anthony Vipin Das was the most influential author with the most relevant literature (n = 45). The electronic medical records were the primary source of ophthalmic big data, and artificial intelligence served as the principal analytics tool. Diabetic retinopathy, glaucoma, and myopia are currently the main topics of interest in this field.
    CONCLUSIONS: The application of big data in ophthalmology has experienced rapid growth in recent years. Big data is expected to play an increasingly significant role in shaping the future of research and clinical practice in ophthalmology.
    Keywords:  Artificial intelligence; bibliometric analysis; big data; diabetic retinopathy; ophthalmology
    DOI:  https://doi.org/10.1080/08820538.2024.2421478
  48. Front Oncol. 2024 ;14 1450475
       Objectives: The objective of this study was to evaluate global longitudinal publication trends in oncology in the Cochrane Database of Systematic Reviews (CDSR) from 2001-2020.
    Design: Retrospective bibliometric analysis.
    Primary and secondary outcome measures: The primary outcome measures were the numbers and percentages of women as first, last, and corresponding author across all CDSR oncology publications. Additional outcomes included authorship differences between countries and percentages of women authors over time compared using the Cochran-Armitage trend test.
    Results: In total, 548 articles were analyzed. Women were first authors in 52.26% (n=277) and corresponding authors in 50.75% (n=272), respectively. Women represented only 39.4% (n=210) of last authors, significantly less frequent than male counterparts (p < 0.001). The percentage of women last and corresponding authors has increased significantly in the past 20 years (p < 0.05). Countries such as the Netherlands and Australia consistently showed equitable representation in first, corresponding, and last authorship, while other countries such as Italy and China had uniformly low rates of female authorship.
    Coclusions: Our results highlight patterns of gender inequity in oncology publication authorship in the CDSR from 2001-2020 at a global level. Notably, women were less likely to serve in the last author position which, independent of assigned corresponding authorship, is generally assumed in academic oncology to designate the leader of a published study. Substantive efforts to correct this disparity are needed to achieve gender parity in publicly perceived leadership in oncology publications.
    Keywords:  Cochrane database of systematic reviews; academic medicine; authorship; gender inequity; oncology; women in medicine
    DOI:  https://doi.org/10.3389/fonc.2024.1450475
  49. Medicine (Baltimore). 2024 Oct 11. 103(41): e40102
       BACKGROUND: The interest on short chain fatty acids (SCFAs) regulating the progress of neurological diseases has gained significant attention in recent years. This bibliometric analysis aimed to provide insights into the current state and future trends of global research on SCFAs in neurological research.
    METHODS: To analysis the general trend of publications, the scientific output in this field from 1995 to 2024 was first retrieved from the Web of Science Core Collection, Scopus, and PubMed with SCFAs-related and neurological diseases related terms as the subjects. Based on above publication analysis, rapid development stage was marked as 2016 to 2024 and 878 relevant original articles in rapid development stage was retrieved with the time limit from 2016 to 2024. Key bibliometric indicators were calculated and evaluated using CiteSpace with these 878 articles.
    RESULTS: SCFAs are related to the occurrence and development of neurological diseases. China and the USA have contributed in a significant way to foster a better understanding on SCFAs in neurological diseases. The hot theme of research have gradually shifted from neurodegenerative diseases to psychical diseases. In the aspect of mechanism research, the current hotspot is inflammation. SCFAs are able to modulate oxidative stress and microglia maturation, morphology and function to intervene in the development of neurological diseases and thus SCFAs interventions are promising to treat neurological diseases. 2016 to 2024 is the fast-developing stage in this field. In this stage the publications dramatically increased and were of high quality.
    CONCLUSION: SCFAs in neurological research will continue to be an active area in the near future. Future trends might be correlation analysis and neurotherapeutics of SCFAs on patients with psychical diseases and deeper mechanism research is still needed.
    DOI:  https://doi.org/10.1097/MD.0000000000040102
  50. Front Nutr. 2024 ;11 1485642
       Objective: The ketogenic diet (KD) has been explored for diabetes management; however, a quantitative synthesis of its specific effects on diabetes has not yet been conducted. This study aims to examine the current status and research hotspots of KD in diabetes management from 2005 to 2024, providing a reference for future research.
    Methods: We retrieved articles published between 2005 and 2024 from the Web of Science database and analyzed them using R software, VOSviewer, and CiteSpace.
    Results: This study includes 432 relevant publications. From 2005 to 2024, the volume of literature in this field has shown a steady upward trend, with a notable increase from 2017 to 2021, and a slight decline observed from 2021 to 2023. The United States is the leading country in terms of the number of publications, followed by China, Australia, and Canada. The United States not only leads in publication volume but also maintains a broader international collaboration network. Nutrients and the American Journal of Clinical Nutrition are the most frequently published and cited journals. Current research hotspots primarily focus on the impact of KD on blood glucose control, insulin resistance, and lipid metabolism in diabetic patients. Mechanistic studies on KD in diabetes management concentrate on aspects such as the "regulation of genes by β-hydroxybutyrate," "anti-inflammatory effects," and "oxidative stress." The role of the gut microbiome is also emerging as an important research area. Currently, exploring the application of KD in managing different age groups and types of diabetes has become a significant research trend.
    Conclusion: As an emerging dietary intervention, KD is gradually attracting widespread attention from researchers around the world and is expected to become a major research focus in the future for diabetes management and control. This paper provides a systematic review and analysis of the current research status and hotspots of KD in diabetes management, offering important references and insights for future research in related fields.
    Keywords:  bibliometrics; diabetes; gut microbiome; insulin resistance; ketogenic diet
    DOI:  https://doi.org/10.3389/fnut.2024.1485642
  51. Forensic Sci Med Pathol. 2024 Oct 30.
      Utilizing a visual analysis of the literature on postmortem interval (PMI) estimation indexed by Web of Science (WOS), this study investigates developmental trends and research hot points across each 5-year period from 2006 to 2020. Additionally, collaborative efforts among authors, countries, and institutions were examined. Research hot points, high-frequency keywords, authors, countries and institutions in relevant papers were analyzed using CiteSpace.5.7.R2 information visualization analysis software over the past 15 years. The literature related to PMI estimation has witnessed consistent growth over time. In the keyword co-occurrence network, several impactful terms stand out, including blowfly, mitochondrial DNA, and emerging concepts like virtual autopsy. Technological advancements, such as RNA stability analysis and virtual autopsy tools, have played a pivotal role in shaping the direction of PMI research. Scientific research institutions dominate the high-frequency affiliations within the institutional cooperative network. Additionally, the country cooperative network exhibits a trend of co-occurrence and multi-clustering. As science and technology continue to advance, traditional PMI estimation methods mature while novel interdisciplinary approaches drive innovation. By identifying emerging trends and research hotspots, this study provides a roadmap for future investigations, guiding researchers toward new opportunities in PMI estimation.
    Keywords:  CiteSpace; Forensic medicine; Postmortem interval estimation; Visual analysis
    DOI:  https://doi.org/10.1007/s12024-024-00908-2
  52. Medicine (Baltimore). 2024 Oct 04. 103(40): e39951
       BACKGROUND: Spinal cord injury has a significant impact on patients' physical and mental health, with cell death playing a key role in the pathology.
    METHODS: The Web of Science Core Collection database was searched and screened according to inclusion criteria for publications between January 1, 2000 and December 31, 2023. Bibliometric analysis was conducted using bibliomatrix R-package, CiteSpace, and VOSviewer software.
    RESULTS: A total of 2309 publications were identified, with a stable growth in the first 13 years and accelerated growth in the past decade, indicating an increasing trend in this field. These publications on cell death after spinal cord injury originated from 251 countries/regions. China contributed the most publications, with funding support primarily from China, and Wenzhou Medical University in China being the leading institution with the highest number of publications. Salvatore Cuzzocrea was the most influential author. The research direction in this field after 2000 mainly focused on topics such as apoptosis, autophagy, mesenchymal stem cells, mammalian target of rapamycin pathway, ferroptosis, functional recovery, neuronal regeneration, and NOD-like receptor protein 3.Current hot topics and future research trends revolve around extracellular vesicles including exosomes, extracellular vesicle-mediated mesenchymal stem cells, microRNA, autophagy, NOD-like receptor protein 3 inflammasome-mediated cell pyroptosis, and mechanisms of glial scar formation.
    CONCLUSION: Publications in this field have grown rapidly in the past 2 decades and are expected to keep increasing. Current hot topics include mesenchymal stem cells, apoptosis, autophagy, and ferroptosis. Future research will focus on extracellular vesicle-mediated mesenchymal stem cells, autophagy, inflammasome-mediated cell pyroptosis, and glial scar formation.
    DOI:  https://doi.org/10.1097/MD.0000000000039951
  53. Environ Sci Pollut Res Int. 2024 Oct 30.
      Transitioning to a circular economy is indispensable for the construction industry to achieve sustainable development goals. Understanding trends, gaps, and opportunities in life cycle assessment (LCA) for adopting a circular economy is critical. This study investigates the development of publications, identifies the most effective documents, authors, and countries, and highlights critical issues, knowledge axes, active research areas, and knowledge gaps. The study screened 196 out of 280 articles from the Scopus database and conducted a bibliometric analysis using CiteSpace and VOSviewer. Document clustering analysis identified the main research domains, and thematic classifications of knowledge areas and axes were provided. Additionally, development opportunities and knowledge gaps were identified through a full-text analysis of selected articles. The results show an increase in publications post-2017, with key research clusters including "Critical consideration," "Circular building component," "Building material," "Design for disassembly," "Integrated load match analysis," "Adaptive reuse project," "Data bank," "Prospective life cycle assessment," "Investment decision," and "Environmental comparison." Over 60% of the documents propose circular design solutions, end-of-life strategies, and alternative materials, while more than 80% focus solely on the environmental aspect. Only 4.6% develop integrated indicators, 2.5% automate LCA, 2.1% compile life cycle inventory databases, and 2% consider the social dimension. The findings emphasize the need to develop integrated indicators, methods, life cycle inventory databases, and automation tools based on integrated platforms and emerging technologies like building information modeling. This research identifies current knowledge gaps, suggests future research directions, and enhances understanding of how to make LCA more compatible with the circular economy.
    Keywords:  Built environment; Environmental impacts; Life cycle assessment; Literature review; Scientometric analysis; Sustainability
    DOI:  https://doi.org/10.1007/s11356-024-35399-9
  54. Neurosurgery. 2024 Oct 28.
       BACKGROUND AND OBJECTIVES: Women represent ∼20% of the national neurosurgical resident cohort but only ∼10% of academic neurosurgeons in the United States. Recognizing that the publication of scientific literature contributes to academic advancement, we measured authorship trends of academic neurosurgeons to query publication differences as an explanation for the discrepancy of female representation in academic positions.
    METHODS: Physician data were obtained from program and individual physician webpages. Annual total, first author, and senior author publications were recorded for each neurosurgeon from 1980 to 2020. Mean publication number as a function of the year relative to residency graduation was calculated for all, first author, and senior author publications for all timepoints with >50 individuals. The mean first years of publication were compared using unpaired 2-tailed t-tests. The slope of publication for the senior author and all publications was calculated using individual best-fit lines from years 0 to 10 relative to residency graduation.
    RESULTS: Overall, 1601 faculty members were evaluated (female = 167 [10.4%], male = 1434 [89.6%]). First-author publication for female members peaked at 0.60 publications/year, and for male members at 0.80 publications/year, both at -1 year from graduation (P = .038). Female first publication occurred earlier (-2.4 vs 1.45 years; P < .00001). The mean increase in all publications/year from years 0 to 10 was 0.25 for women and 0.28 for men (P = .68). The increase in senior publications/year was 0.11 for women and 0.13 for men (P = .39). The ratio of total publications to the Scopus h-index was 3.08 for women and 3.62 for men (P = .07).
    CONCLUSION: These data suggest that women publish earlier but have fewer first-author publications at -1 year, the timepoint of peak publication for both genders. There was no significant gender difference in rates of the first author and all publications over the years 0 to 10. The ratio of publications to the h-index did not differ significantly but showed a trend suggesting that women produce higher-impact articles and may need fewer publications to achieve the same change in the h-index.
    DOI:  https://doi.org/10.1227/neu.0000000000003252
  55. J Neurol Surg B Skull Base. 2024 Dec;85(6): 563-568
      Background  The membership of the North American Skull Base Society (NASBS) has grown considerably in recent years with diversity in subspecialty training, gender, and geography. The academic relationships and contributions of its membership have not been studied. Objectives  This study aimed to (1) measure academic contributions of NASBS membership; (2) identify influential nodes of academic collaboration; (3) identify opportunities for future collaboration and mentorship. Methods  Peer-reviewed publications of members of NASBS (2019 NASBS website) were identified using Scopus author name search. Network structures were constructed and analyzed using the graph-tool python library to produce a weighted coauthorship network and compute centrality measures. Visual network maps were then produced using Gephi network visualization software. Results  The coauthor network contained 952 members with found publications and 4,996 connections. A total of 846 (88.9%) members were contained in a single connected giant component; 102 members were unconnected, and 64 members had a single connection. Girvan-Newman clustering identified 267 communities, where 13 contained at least 1% of the total membership each. The three largest communities contained 23.3, 8.4, and 6.9% of members. There were 111 published members identified as women; 5.4% of women were unconnected versus 11.4% of men. Average publication count for women was 32.3 (standard deviation [SD] 38.5) versus 70.5 (SD 106) for men. Average citation count for women was 543 (SD 1,012) versus 1,389 (SD 2,893) for men. Conclusion  Network mapping of membership of the NASBS helps to visualize the academic activities and relationships of the NASBS and reveals areas of concentration and influence within the specialty.
    Keywords:  gender; network; publications; society
    DOI:  https://doi.org/10.1055/a-2297-9338
  56. Arq Bras Oftalmol. 2024 ;pii: S0004-27492024000600100. [Epub ahead of print]87(6): e20241012
      
    DOI:  https://doi.org/10.5935/0004-2749.2024-1012
  57. Arch Public Health. 2024 Oct 28. 82(1): 193
      Total Quality Management (TQM) is instrumental in augmenting the quality and efficacy of healthcare service delivery, but a comprehensive evaluation of present and evolving TQM research trends within healthcare research articles is notably absent. This study provides an insightful view into the prevailing international scenarios and upcoming research frontiers in healthcare TQM research field, utilizing bibliometric mapping through VOSviewer. Drawing data from 360 publications in the Web of Science core citation database, it delineates a steady growth in the field over the last 30 years. Research outputs span 51 countries and regions, with notable contributions from the United States, United Kingdom, Netherlands, and Italy. The top five research institutions and numerous authors predominantly hail from the United States. Key keywords in near years encompass healthcare safety, healthcare quality assurance, quality indicators, and the application of Six Sigma management principles. This exploration serves as a pivotal reference for understanding the global research landscape and future trends in healthcare TQM, particularly in guaranteeing quality and safety. Future scientific endeavors will build upon these focus areas, exploring and connecting research gaps in more specialized fields.
    Keywords:  Bibliometric study; Big data; Healthcare management; Total quality management
    DOI:  https://doi.org/10.1186/s13690-024-01420-3
  58. J Surg Res. 2024 Oct 24. pii: S0022-4804(24)00595-X. [Epub ahead of print]303 731-743
       INTRODUCTION: No investigation of each nation's contribution to knowledge production and human capital in surgery currently exists. Previous studies explored country-level research productivity only in few surgical subspecialties. To identify current and future leaders in surgery research, we conduct a retrospective observational study of each country's human capital and research productivity.
    METHODS: A web-scraping algorithm was deployed on PubMed to retrieve information on the first and senior author of every publication in all PubMed-indexed surgery outlets-a total of 388 journals-between 2010 and 2022, according to the SCImago classification. Each country's human capital is proxied by the number of first and senior authors.
    RESULTS: A total of 665,668 publications from 110 countries were reviewed. The number of publications rises over time. The United States represents 30.78% and 31.32% of global publications based on first and senior authors, respectively. Other leading contributors include the United Kingdom (5.57% and 5.69% of global first and senior author publications, respectively), China (8.84% and 8.74%), Japan (7.14% and 7.10%), and Italy (4.54% and 4.46%). The number of publications per 100K people ranges between 0.04 and 86.01, suggesting widely varying levels of research productivity relative to the population.
    CONCLUSIONS: Our findings underscore the US dominance in surgery research. Countries with a higher share of first or senior authors may have greater capacity to expand their future research output. As big data research expands, we expect studies deploying artificial intelligence methodologies, such as web scraping, on data repositories to guide healthcare provision and health policy decisions to become mainstream.
    Keywords:  First authors; Human capital; Publications; Research productivity; Senior authors; Surgery; Web scraping
    DOI:  https://doi.org/10.1016/j.jss.2024.09.047
  59. J Transl Med. 2024 Oct 30. 22(1): 982
       BACKGROUND: Osteonecrosis of the femoral head (ONFH) significantly impacts young and middle-aged adults, with steroid use implicated in many cases. Traditional treatments have limited efficacy, prompting a shift towards innovative approaches, such as stem cell therapy, offering less invasive regenerative solutions.
    METHODS: Using bibliometric analysis from 1997 to 2023, we identified 392 articles on stem cell therapy for ONFH from the Web of Science Core Collection and analysed them using VOSviewer and CiteSpace to identify key trends and research directions.
    RESULTS: From 1997 to 2023, stem cell therapy for ONFH research expanded significantly, with 392 articles evidencing global collaboration, particularly from China, the United States and South Korea. The field is characterised by 158 core authors across 26 clusters and contributions from 417 institutions in 104 research clusters, with Shanghai Jiao Tong University as a notable leader. This research is disseminated through 23 journal clusters, emphasising interdisciplinary work, with Clinical Orthopaedics and Related Research among the most influential journals. Key findings include the identification of the most influential papers, highlighting advances, such as use of autologous mesenchymal stem cells (MSCs) and innovative delivery mechanisms. High-frequency keyword analysis further mapped the evolution of the field, from basic mechanisms to advanced therapies, underscoring a trend towards more targeted stem cell treatments for ONFH.
    CONCLUSION: Stem cell therapy for ONFH has advanced significantly, showcasing a successful transition from basic research to clinical practice, particularly highlighted by developments in use of autologous MSCs and delivery methods. Future research will focus on refining therapies through exosome technology, targeted modulation of stress and inflammation and integration with surgical techniques, with the aim of tailored patient care and improved ONFH outcomes.
    Keywords:  Basic research; Bibliometric; Clinical practice; Osteonecrosis of the femoral head; Stem cell therapy
    DOI:  https://doi.org/10.1186/s12967-024-05784-6
  60. PLoS One. 2024 ;19(10): e0311493
      Calls to make scientific research more open have gained traction with a range of societal stakeholders. Open Science practices include but are not limited to the early sharing of results via preprints and openly sharing outputs such as data and code to make research more reproducible and extensible. Existing evidence shows that adopting Open Science practices has effects in several domains. In this study, we investigate whether adopting one or more Open Science practices leads to significantly higher citations for an associated publication, which is one form of academic impact. We use a novel dataset known as Open Science Indicators, produced by PLOS and DataSeer, which includes all PLOS publications from 2018 to 2023 as well as a comparison group sampled from the PMC Open Access Subset. In total, we analyze circa 122'000 publications. We calculate publication and author-level citation indicators and use a broad set of control variables to isolate the effect of Open Science Indicators on received citations. We show that Open Science practices are adopted to different degrees across scientific disciplines. We find that the early release of a publication as a preprint correlates with a significant positive citation advantage of about 20.2% (±.7) on average. We also find that sharing data in an online repository correlates with a smaller yet still positive citation advantage of 4.3% (±.8) on average. However, we do not find a significant citation advantage for sharing code. Further research is needed on additional or alternative measures of impact beyond citations. Our results are likely to be of interest to researchers, as well as publishers, research funders, and policymakers.
    DOI:  https://doi.org/10.1371/journal.pone.0311493
  61. J Environ Manage. 2024 Oct 28. pii: S0301-4797(24)03004-4. [Epub ahead of print]371 123018
      In recent decades, research on treatment and recycling of construction and demolition waste (CDW) has rapidly increased due to its substantial environmental, social, and economic impacts. Despite the growing interest in this field, there is a noticeable lack of comprehensive and systematic analysis offering a clear overview of the development context and quantitative trends. To address this gap, this study conducted a systematic bibliometric overview that covers publishing trends, collaborative networks among countries, institutions and research teams, co-citation analysis of literatures, and keyword co-occurrence analysis using literature data-driven visualization. Research trends and future perspectives were identified based on the results and comprehensive review as well as the keywords clusters visualized by literature data. These perspectives highlight several research opportunities. (1) Advanced technologies for CDW treatment are underutilized, which necessitates government involvement and a national disposal charging system. (2) There is a lack of interdisciplinary integration in CDW research. (3) A universally applicable life cycle assessment system for CDW recycling needs to be developed. (4) Research on heavy metal migration and long-term stability in recycled CDW is limited. (5) More studies on CDW reduction in the design stage are warranted, with emphasis on urban planning, building quality, design optimization, and resource estimation. These findings not only enhance understanding of the research trends in treatment and recycling of CDW but also for provide insights for practitioners and researchers at the evolving frontiers of the field.
    Keywords:  Bibliometric analysis; Construction and demolition waste; Literature data-driven visualization; Treatment and recycling; Waste management
    DOI:  https://doi.org/10.1016/j.jenvman.2024.123018
  62. J Palliat Care. 2024 Oct 29. 8258597241291631
      Objective: Although the representation of women in palliative care has improved in recent years, gender inequality still exists in editorial leadership. This study aimed to characterize gender distribution in leadership positions on the editorial boards of palliative care journals. Methods: This cross-sectional study analyzed the gender composition of editorial boards for palliative care journals indexed in the Web of Science (WoS) and the factors that affect this composition. Information on the gender of editorial board members was obtained from each journal's website. Results: A total of 1388 editorial board members from 28 palliative care journals were included in the analysis. The data analysis showed that 540 (38.9%) of the editorial board members were women, while 848 (61.1%) were men. Of the 31 editors-in-chief, only 11 (35.5%) were women. Editorial boards of journals classified as social work (OR, 5.92, 95% CI, 2.29-15.30, p < 0.001) and nursing (OR, 4.20, 95% CI, 1.73-10.17, p = 0.001) in WoS coverage were independently associated with gender diversity. There were differences in gender representation between the editorial boards of palliative care journals published in New Zealand (OR, 0.49, 95% CI, 0.29-0.80, p = 0.005), Japan (OR, 0.17, 95% CI, 0.08-0.32, p < 0.001), and those categorized under oncology in WoS coverage (OR, 0.64, 95% CI, 0.05-0.89, p = 0.009). Conclusions: Our findings demonstrated that women are underrepresented among editorial board members of palliative care journals. Additional efforts are required to broaden diversity policies in palliative care.
    Keywords:  Gender equity; female; leadership; male; palliative care; women leadership
    DOI:  https://doi.org/10.1177/08258597241291631
  63. J Multidiscip Healthc. 2024 ;17 4877-4892
       Objective: To explore the research trends and hotspots of health economics evaluations of patients with chronic fatigue syndrome.
    Methods: To explore the research trends and hotspots of health economics evaluations of chronic fatigue syndrome, 180 articles published between 1991 and 2024 were visualized and analyzed via CiteSpace 6.3 software. R3 and VOSviewer1.6.20 and R4.3.3. The content includes annual publication volume, journal distribution, author country, publishing organization, author collaboration, citation analysis, and keyword analysis in 7 aspects.
    Results: Fewer studies have evaluated the health economics of individuals with chronic fatigue syndrome in China and abroad, Chinese studies are especially rare, and research results in the UK are mostly found in other countries. Moreover, cooperation and linkages between institutions, as well as between authors, are not yet strong.
    Conclusion: The hotspot of health economics evaluation methods in this field is cost-effectiveness analysis, and the hotspot of diagnosis and treatment methods is cognitive‒behavioral therapy. We also found that chronic fatigue syndrome may also have a strong potential association with depression from the perspective of health economics. Health economic evaluations of multiple treatments should be conducted simultaneously to increase attention to this field and provide a reference basis for low-cost and high-quality diagnostic and treatment programs.
    Keywords:  CiteSpace; bibliometrics; chronic fatigue syndrome; health economics; myalgic encephalomyelitis; visual analysis
    DOI:  https://doi.org/10.2147/JMDH.S482100
  64. Nurs Outlook. 2024 Oct 29. pii: S0029-6554(24)00196-9. [Epub ahead of print]72(6): 102303
       BACKGROUND: It is not currently known how often nursing theory is cited in non-nursing publications.
    PURPOSE: The purpose of this study was to document citations of five nursing theories in non-nursing publications, including author discipline, type of publication, and publication discipline.
    METHODS: Over 75 non-nursing disciplines cited nursing theories and were consolidated for reporting purposes.
    DISCUSSION: Leininger, Pender, Parse, and Orem were most often cited in research articles, and Watson was cited more frequently in books.
    CONCLUSION: Nurse scholars can use these findings to improve interprofessional education and practice and further develop and disseminate nursing knowledge.
    Keywords:  Citation search; Nursing influence; Nursing knowledge; Nursing research; Nursing theory
    DOI:  https://doi.org/10.1016/j.outlook.2024.102303
  65. Plants (Basel). 2024 Oct 10. pii: 2836. [Epub ahead of print]13(20):
      Worldwide, cancer ranks among the foremost contributors to mortality despite recent medical progress. Alternative approaches in controlling various forms of cancer are being highly explored by researchers. This study provides the global research trends in the utilization of medicinal plant-synthesized nanoparticles for cancer treatment over the span of 18 years using scientometric analysis. Recent research advances on medicinal plant-derived nanoparticles for cancer treatment and their possible mechanisms of action were described. Relevant articles published between 2005 and 2023 were retrieved from Scopus and Web of Science and analyzed using RStudio and VOSViewer. Scientometric indicators were employed to analyze the results. The initial search returned 5695 articles, with a publication growth rate of 3.71% annually. Countries from Asia contributed the most (61.37%) to the total number of publications. The therapeutic effects of nanoparticles derived from medicinal plants can be attributed to various mechanistic pathways, including induced apoptosis from reactive oxygen species generation, as well as mitochondrial and cell membrane disruption, amongst others. Although some reported studies demonstrated promising safety and efficacy against certain cancer cells in vivo and in vitro, the little to no clinical data on medicinal plant-synthesized nanoparticles hinder the ability to make informed decisions about their clinical potential in cancer treatment.
    Keywords:  anticancer activity; apoptosis; bibliometric analysis; drug delivery; medicinal plants; nanomedicine
    DOI:  https://doi.org/10.3390/plants13202836
  66. Braz Dent J. 2024 ;pii: S0103-64402024000100309. [Epub ahead of print]35 e246110
      Nonsurgical therapies have been recommended and employed as a less invasive and cost-effective modality in managing periodontitis. In this context, different therapeutic protocols have been tested in the last decades. Therefore, mapping the scientific trends and patterns provides critical insights into the state of research in the field, which has not been explored for overall nonsurgical periodontitis treatment studies. Articles from 2001 to 2020 were retrieved from the Web of Science database using appropriate terms and keywords. Article selection and data extraction were performed by calibrated examiners. All articles focusing on nonsurgical periodontitis treatment were included. Descriptive, bivariate, and multivariate logistic regression analyses were conducted. 1,519 articles were included. Randomized clinical trials (RCTs) were the most used design (44.1%), and professional biofilm control was the topic most studied (35.6%). Europe published the most significant number of articles (41.1%). The USA was the country that collaborated more with other countries. Asia (p<0.001), South America (p=0.004), and Oceania/Africa (p=0.016) showed a lower chance to have international collaboration. Studies from North America were more likely to be RCTs than studies from Europe (p=0.050); studies focusing on professional biofilm control (p<0.001) and other topics (p<0.001) were less likely to be evaluated by RCTs. The nonsurgical periodontitis treatment field mainly conducted RCTs, and the topic most explored by all studies was professional biofilm control. International collaboration and conduct of RCTs in this field occurred mainly among high-income countries. Decentralizing scientific resources, making integrative connections globally, and evaluating new topics may improve evidence-based periodontology.
    DOI:  https://doi.org/10.1590/0103-6440202406110
  67. Microorganisms. 2024 Oct 03. pii: 2010. [Epub ahead of print]12(10):
      The skin plays a crucial role in maintaining homeostasis and protecting against external aggressors. Recent research has highlighted the potential of probiotics and postbiotics in dermatological treatments and skincare. These beneficial microorganisms interact with the skin microbiota, modulate the immune response, and enhance the skin barrier, offering a promising therapeutic avenue for various skin conditions, such as acne, dermatitis, eczema, and psoriasis. This bibliometric study aims to analyze the global trends and scientific impact of topical probiotics in dermatology. By reviewing 106 articles published between 2013 and 2023, the study categorizes the applications of probiotics in wound healing, inflammatory skin diseases, and general skincare. The findings indicate a significant increase in publications from 2021 onwards, attributed to the heightened focus on medical research during the COVID-19 pandemic. This study also identifies the most productive countries, institutions, and authors in this field, highlighting the importance of international collaborations. The results underscore the efficacy of probiotic-based topical formulations in improving skin health, reducing inflammation, and enhancing wound healing. This comprehensive analysis supports the development of new therapeutic strategies based on topical probiotics and encourages high-quality research in this promising area.
    Keywords:  inflammatory skin diseases; skin care; skin microbiome; topical probiotics; wound healing
    DOI:  https://doi.org/10.3390/microorganisms12102010
  68. J Neurol Surg B Skull Base. 2024 Dec;85(6): 555-562
      Objectives  Our objective was to elucidate the demographic, academic, and career attributes of North American Skull Base Society (NASBS) presidents and determine how leadership of this society has changed over time. Design  Thirty-one NASBS presidents have served between 1990 and 2021. Demographic and scholarly variables were recorded from publicly available sources. To determine how trends in NASBS presidents have changed over time, linear and logistic regressions were conducted on continuous and categorical variables, respectively. Setting  Virtual setting was used for this study. Participants  There were no active participants in the study. Main Outcome Measures  Academic metrics of NASBS presidents were the main outcome measure. Results  NASBS presidents had a mean age of 53.3 ± 6.1 years at election and were all male. The most common institution at which former presidents trained ( n  = 4) and practiced ( n  = 3) was the University of Pittsburgh. Otolaryngologists comprised 41.9% ( n  = 13) of the cohort, neurosurgeons made up 38.8% ( n  = 12), and the remaining 19.3% ( n  = 6) were from other specialties. NASBS presidents from neurosurgery ( p  = 0.033) and other specialties ( p  = 0.014) were more likely to hold the rank of chair compared with those from otolaryngology. Over time, there has been a linear increase in years of research experience at the time of election ( p  = 0.048). There remains a lack of diversity of gender and race. Conclusion  NASBS presidents have demonstrated increased research activity over time, favoring long-term academic careers. Knowledge of these trends and attributes, which demonstrate an increase in skull base literature, growth of the NASBS, and a need for increased diversity in the field, is important for stewarding the future of the NASBS and promoting equity.
    Keywords:  h-index; leadership; neurosurgery; otolaryngology; skull base
    DOI:  https://doi.org/10.1055/a-2215-0870
  69. Front Immunol. 2024 ;15 1489276
      [This corrects the article DOI: 10.3389/fimmu.2024.1451742.].
    Keywords:  CiteSpace; VOSviewer; bibliometrics; gut microbiota; multiple sclerosis; scientometric
    DOI:  https://doi.org/10.3389/fimmu.2024.1489276
  70. Bone Jt Open. 2024 Nov 01. 5(11): 953-961
       Aims: The evidence base within trauma and orthopaedics has traditionally favoured quantitative research methodologies. Qualitative research can provide unique insights which illuminate patient experiences and perceptions of care. Qualitative methods reveal the subjective narratives of patients that are not captured by quantitative data, providing a more comprehensive understanding of patient-centred care. The aim of this study is to quantify the level of qualitative research within the orthopaedic literature.
    Methods: A bibliometric search of journals' online archives and multiple databases was undertaken in March 2024, to identify articles using qualitative research methods in the top 12 trauma and orthopaedic journals based on the 2023 impact factor and SCImago rating. The bibliometric search was conducted and reported in accordance with the preliminary guideline for reporting bibliometric reviews of the biomedical literature (BIBLIO).
    Results: Of the 7,201 papers reviewed, 136 included qualitative methods (0.1%). There was no significant difference between the journals, apart from Bone & Joint Open, which included 21 studies using qualitative methods, equalling 4% of its published articles.
    Conclusion: This study demonstrates that there is a very low number of qualitative research papers published within trauma and orthopaedic journals. Given the increasing focus on patient outcomes and improving the patient experience, it may be argued that there is a requirement to support both quantitative and qualitative approaches to orthopaedic research. Combining qualitative and quantitative methods may effectively address the complex and personal aspects of patients' care, ensuring that outcomes align with patient values and enhance overall care quality.
    DOI:  https://doi.org/10.1302/2633-1462.511.BJO-2024-0145.R1
  71. Medicine (Baltimore). 2024 Oct 11. 103(41): e39893
      To systematically present an overview of randomized controlled trials on transcutaneous electrical acupoint stimulation (TEAS) using bibliometric methods, and describe the role and mechanisms of TEAS in most prevalent diseases. Relevant literature was searched in China National Knowledge Infrastructure, Wanfang Data, VIP, SinoMed, PubMed, and Web of Science. The literature was imported and screened into NoteExpress, screened according to inclusion and exclusion criteria, and analyzed using Excel and CiteSpace 6.3R1 software. A total of 1296 documents were included. The number of publications increased annually after 2012. Junlu Wang was the most prolific author. The main research institutions were Peking University, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Shuguang Hospital, and Tongde Hospital of Zhejiang Province. The research hotspots in this field include perioperative care, cancer, pain management, and stroke, primarily focusing on analgesia, immune enhancement, antihypertension, and reduction of gastrointestinal disorders. The main regulatory mechanisms of TEAS include the control of inflammation, oxidative stress, and regulation of the autonomic nervous system. TEAS is most widely used in the elderly, with PC6, ST36, and LI4 being the most frequently studied acupoints in clinical randomized controlled trials. The concept of accelerated rehabilitation is gradually being applied to TEAS, representing an emerging trend for future development. Clinical research on TEAS is rapidly developing, with a focus on applications in cancer and perioperative care. Future research should expand collaboration and conduct high-level clinical and mechanistic studies, which will contribute to the development of standardized protocols and clinical practice.
    DOI:  https://doi.org/10.1097/MD.0000000000039893
  72. Front Pediatr. 2024 ;12 1460954
       Objective: By analyzing high readership articles from the Chinese Journal of Contemporary Pediatrics (CJCP) in the PubMed Central (PMC) database, this study aims to identify research hotspots and trends in the field of pediatrics.
    Methods: Articles from the CJCP ranked by annual readership in PMC from 2021 to 2023 were collected. Using word frequency analysis and co-word analysis, the thematic characteristics of these articles were explored.
    Results: The word frequency analysis and co-word analysis revealed four thematic directions that were of significant interest to researchers: (1) current public health or medical events such as COVID-19 and influenza; (2) mental health issues in children and adolescents; (3) pediatric neurological diseases and neurodevelopment; (4) diseases in preterm infants and newborns.
    Conclusions: This study provides pediatric researchers with a valuable perspective to understand and grasp the development dynamics and future directions in the field of pediatrics.
    Keywords:  PubMed Central; co-word analysis; pediatrics; research hotspots; word frequency analysis
    DOI:  https://doi.org/10.3389/fped.2024.1460954
  73. J Neurol Surg B Skull Base. 2024 Dec;85(6): 569-574
      Background  Little is known about the relative contributions and interactions of the past presidents of the North American Skull Base Society (NASBS) and skull base centers. Objectives  (1) Measure academic contributions of past presidents; (2) identify influential nodes of academic collaboration; (3) identify opportunities for future collaboration. Methods  Peer-reviewed publications of past presidents of NASBS from 1964 to July 2019 were identified using Scopus author name search. Network structures were constructed and analyzed using the graph-tool python library to produce a weighted co-authorship network base and compute centrality measures. Girvan-Newman clustering was applied to identify community structure. Network maps were then produced using Gephi network visualization software with force-directed layout algorithms. Results  The coauthor network of 29 presidents was fully connected, with a maximum shortest-path distance between presidents of 5. The mean number of connections from each node without respect to weighting was 5.31 (standard deviation [SD]: 3.53), and the mean number of connections with weighting was 8.40 (SD: 7.28). The number of unweighted connections ranged from 1 to 14 and weighted connections ranged from 0.25 to 24.7. Girvan-Newman clustering identified three communities with two that covered 93% of the network. The largest communities contained 14 and 13 presidents. The number of connections was correlated with h-index, both unweighted ( r 2  = 0.34) and weighted ( r 2  = 0.26). Conclusion  Network mapping of past presidents of the NASBS helps to capture the history of the NASBS and reveals areas of concentration and influence within the specialty.
    Keywords:  history; network; presidents; skull base
    DOI:  https://doi.org/10.1055/a-2297-9267
  74. J Hazard Mater. 2024 Oct 28. pii: S0304-3894(24)02877-2. [Epub ahead of print]480 136298
      Since polybrominated diphenyl ethers (PBDEs) are on the list of regulated chemicals, novel brominated flame retardants (NBFRs) have been produced as alternatives and extensively used since the end of the 19th century. A comprehensive assessment of the environmental burden of NBFRs, which are emerging contaminants with bio-toxic and carcinogenic properties, is urgently needed. Given that soil is a major sink for organic pollutants, this study systematically reviewed global data on NBFRs in soil for the period of 1990-2024 via a bibliometric analysis of 70 publications from the Web of Science Core Collection, reaching the following achievements. (1) NBFRs in soils have been reported in 17 countries or regions worldwide, ranging from not detected to 8.46 × 104 ng/g dw, showing an increasing trend over time, with severe contamination in Asia and Australia. (2) NBFR concentrations varied significantly across land use types: manufacturing land > electronic waste disposal areas > urban soil > farmland > forest > remote areas. (3) NBFRs with log KOA > 10 tend to settle from the air into the soil, where they may be absorbed by plant roots and bioaccumulate in the food chain. (4) Organism dietary habits and metabolism, along with the hydrophobicity and molecular weight of NBFRs, contribute to bioaccumulation differences. (5) Successive reductive debromination is the primary degradation pathway for NBFRs, and microorganisms such as the white-rot fungus P. ostreatus show potential for remediating NBFR-contaminated soil. This review clarifies the pollution status of soil NBFRs and provides a solid reference to develop management policies. Future research should focus on studying the transport mechanisms of NBFRs between soil and other media, and assessing the cumulative effects of high trophic level organisms on NBFRs.
    Keywords:  Bibliometric analysis; Novel brominated flame retardants (NBFRs); Phase transfer; Potential source; Soil contamination
    DOI:  https://doi.org/10.1016/j.jhazmat.2024.136298
  75. Neuroepidemiology. 2024 Oct 28. 1-15
       BACKGROUND: Cerebrovascular accident (CVA) is an outdated term for describing stroke as it implies stroke is an accident. We conducted an integrative review to determine use of CVA in terms of 1) frequency in major medical journals over time; 2) associated publication characteristics (e.g., number of authors, senior author country, topic); and 3) frequency in medical records.
    METHODS: We searched Google Scholar for publications in leading neurology and vascular journals (Quartile 1) across two 5-year periods (1998-2002 and 2018-2022) using the terms "cerebrovascular accident" or "CVA." Two reviewers independently reviewed full-text publications and recorded the frequency of CVA use. Rates of use (per 1,000 articles/year) were calculated for each journal and time period. Associations of publication characteristics with CVA use were determined using multivariable logistic regression models. In addition, admission and discharge forms in the Auckland Regional Community Stroke Study (ARCOS V) were audited for frequency of use of the term CVA.
    RESULTS: Of the 1,643 publications retrieved, 1,539 were reviewed in full. Of these, CVA was used ≥1 time in 676 publications, and ≥2 times in 276 publications (129 in 1998-2002; 147 in 2018-2022). The terms CVA and stroke both appeared in 57% of publications where CVA was used ≥2 times in 1998-2002, compared to 65% in 2018-2022. Majority of publications were on the topic of stroke (22% in 1998-2002; 20% in 2018-2022). There were no associations between publication characteristics and the use of CVA. The highest rate of CVA use in 2018-2022 was in Circulation, and increased over time from 1.3 uses per 1,000 publications in 1998-2002 to 1.8 uses per 1,000 publications in 2018-2022. The largest reduction the use of CVA was in Neuroepidemiology (2.0 uses per 1,000 publications in 1998-2002 to 0 uses in 2018-2022). The term CVA was identified in 0.2% of stroke admission and discharge forms audited (17/7808).
    CONCLUSION: We found evidence of changes in the use of CVA in the scientific literature over the past two decades. Editors, authors and clinicians should avoid the use of the term CVA as it perpetuates the use of a non-specific, non-diagnostic, and non-scientific term.
    DOI:  https://doi.org/10.1159/000542301
  76. PLoS One. 2024 ;19(11): e0305970
       BACKGROUND: Limitation declarations are commonly deemed essential to uphold intellectual humility for scientific research, but little has been reported about the limitation statements in published original research articles. This meta-research study aims to investigate the trends of limitation statements among three leading general medical journals in the US.
    METHODS: This cross-sectional study will compile a data set of full-length original research articles published in the New England Journal of Medicine, Journal of the American Medical Association, and Annals of Internal Medicine between 2002 and 2022. Limitation statement will be recognized by two investigators, and a predefined set of sensitive keywords is used for sensitivity analysis. Frequency of limitation statements within the main text of research articles and trends for different study designs, including their association with the corresponding reporting guidelines, are the main measurements. We employ the Cochran-Armitage test for trend analysis.
    CONCLUSION: The findings of this study will provide an overview of the limitation statements in leading general medical journals in the US. The results may contribute to future research to identify factors that are associated with the presence of limitation statements.
    DOI:  https://doi.org/10.1371/journal.pone.0305970