bims-evares Biomed News
on Evaluation of research
Issue of 2024–01–28
74 papers selected by
Thomas Krichel, Open Library Society
  1. Bibliometric Evaluation of the 100 Top-Cited Articles on Anesthesiology.
  2. A bibliometric analysis of the research hotspots and frontiers related to cell death in spinal cord injury.
  3. Knowledge mapping of immunotherapy in cervical carcinoma: a bibliometric analysis (2000-2023).
  4. Traumatic spinal cord and spinal column injuries: A bibliometric analysis of the 200 most cited articles.
  5. Bibliometric analysis of mucosal immunity in IgA nephropathy from 1990 to 2022.
  6. Current perspectives and trends in the treatment of brain arteriovenous malformations: a review and bibliometric analysis.
  7. Contributions of Machine Learning in the Management of Stroke: A Bibliometric analysis of the 50 most cited articles.
  8. The scholarly footprint of ChatGPT: a bibliometric analysis of the early outbreak phase.
  9. A Bibliometric Analysis of Uveitis in the Past 20 Years.
  10. Top 50 Most-Cited Studies about Osteochondritis Dissecans.
  11. Hotspots and trends of microglia in Alzheimer's disease: a bibliometric analysis during 2000-2022.
  12. Global research status of localised scleroderma reported over the period 1993-2022: A 30-year bibliometric analysis.
  13. The relationship between kidney disease and mitochondria: a bibliometric study.
  14. Unveiling the landscape of cytokine research in glioma immunotherapy: a scientometrics analysis.
  15. Research hotspots and frontiers of neuromodulation techniques in disorders of consciousness: a bibliometric analysis.
  16. Global research trends in cutaneous neurofibromas: A bibliometric analysis from 2003 to 2022.
  17. Bibliometric and visual analysis of single-cell sequencing from 2010 to 2022.
  18. Bridging knowledge gaps: a bibliometric analysis of non-invasive ventilation in palliative care studies.
  19. Repercussions of the Emergency neurological life support on scientific literature: a bibliometric study.
  20. Current global status of Candida auris an emerging multidrug-resistant fungal pathogen: bibliometric analysis and network visualization.
  21. Research landscape and trends of cerebral amyloid angiopathy: a 25-year scientometric analysis.
  22. Visual Knowledge Domain of Artificial Intelligence in Computed Tomography: A Review Based on Bibliometric Analysis.
  23. Research trend of epigenetics and depression: adolescents' research needs to strengthen.
  24. Bibliometric and visual analysis of intestinal flora and immunity.
  25. Bibliometric review of carbon peak with CiteSpace: evolution, trends, and framework.
  26. Congenital heart disease research landscape in the Arab world: a 25-year bibliometric review.
  27. Bibliometric and visualized analysis of randomized controlled trials in orthodontics between 1991 and 2022.
  28. Global research trends and hotspots on tendon-derived stem cell: a bibliometric visualization study.
  29. Worldwide productivity and research trend on fruit quality: a bibliometric study.
  30. Knowledge map of thrombopoietin receptor agonists: A bibliometric analysis.
  31. The gender role in the publishing of Authorships in high-impact orthopedic journals.
  32. Global landscape of COVID-19 research: a visualization analysis of randomized clinical trials.
  33. Scientific Publications and Subject Clusters in the Field of Glaucoma: A Scientometric Analysis.
  34. A bibliometric and visual analysis of the use of ustekinumab in Crohn's disease using CiteSpace.
  35. Bibliometric Analysis of Cannabis sativa Research: Trends, Challenges, and Future Directions.
  36. Bibliometric and visual analysis in the field of tea in cancer from 2013 to 2023.
  37. Research trends in contemporary health economics: a scientometric analysis on collective content of specialty journals.
  38. Effects of Physical Activity on Body Composition, Muscle Strength, and Physical Function in Old Age: Bibliometric and Meta-Analyses.
  39. Medical education research study quality instrument: an objective instrument susceptible to subjectivity.
  40. Food Retail Resilience Pre-, during, and Post-COVID-19: A Bibliometric Analysis and Research Agenda.
  41. Graphene Oxide (GO) for the Treatment of Bone Cancer: A Systematic Review and Bibliometric Analysis.
  42. Artificial Intelligence in Drug Discovery: A Bibliometric Analysis and Literature Review.
  43. Sex Disparities in Academic Productivity and Rank Among Abdominal Transplant Faculty in the United States.
  44. Global trends in bufalin application research for cancer from 2003 to 2022: A bibliometric and visualised analysis.
  45. Analyzing the Spread of Informatics with PubMed.
  46. General practice-related MeSH terms in main journals: a bibliometric analysis from 2011 to 2021.
  47. Global Research Output of Lutetium-177 PSMA in Prostate Cancer: Bibliometric and Altmetric Analyses.
  48. Research trends on maxillary sinus septa in 2019-2021: a scoping review with scientometric analysis.
  49. Quantitative analysis and visualization of literature on acupuncture and related TCM therapies for the treatment of colorectal cancer based on CiteSpace.
  50. An Emerging Foodborne Pathogen Spotlight: A Bibliometric Analysis and Scholarly Review of Escherichia coli O157 Research.
  51. Assessment of Medical Student Research Mentorship in Radiation Oncology.
  52. Trends and Future Research in Skeletal Muscle Tissue Engineering in the Past Decade (2012-2022).
  53. Gender mainstreaming at 25 years: Toward an inclusive, collaborative, and structured research agenda.
  54. Characteristics of retracted research papers before and during the COVID-19 pandemic.
  55. A Decade of Global Skull Base Researchers: Authorship Trends from 3,295 Abstracts in the Journal of Neurological Surgery Part B: Skull Base.
  56. A Decade of Global Skull Base Researchers: Gender Data from over 2,700 Abstract Authors in the Journal of Neurological Surgery Part B: Skull Base.
  57. A critical review on the ecotoxicity of heavy metal on multispecies in global context: A bibliometric analysis.
  58. Energy retrofitting strategies for existing buildings in Malaysia: A systematic review and bibliometric analysis.
  59. A text mining and network analysis of topics and trends in major nursing research journals.
  60. Are We Where We Want to Be in Undergraduate Pathology Education?
  61. Digital Health for Myocardial Infarction: Research Topics and Trends.
  62. Cereal-legume intercropping: a smart review using topic modelling.
  63. Global research hotspots and trends in non-surgical treatment of adolescent idiopathic scoliosis over the past three decades: a bibliometric and visualization study.
  64. Fostering Motivation: Exploring the Impact of ICTs on the Learning of Students with Autism.
  65. Multi-Algorithm Analysis Reveals Pyroptosis-Linked Genes as Pancreatic Cancer Biomarkers.
  66. I forgot that you existed: Role of memory accessibility in the gender citation gap.
  67. Regional Agriculture and Food Systems Amid the COVID-19 Pandemic: The Case of the Near East and North Africa Region.
  68. Digital technologies (DTs) for safety education and training in construction.
  69. Visualization analysis of research progress for walkability.
  70. National Institutes of Health Funding for Surgeon-Scientists in the US-An Update and an Expanded Landscape.
  71. State of the art, trends, hotspots, and prospects of injection materials for controlling bleeding.
  72. Trends in Female Authorship over 5-year Publication History in Neurovascular surgery.
  73. Investigating the citing communities around three leading health-system frameworks.
  74. Corrigendum to "Bibliometric and visual analyses of trends in the field of T cell exhaustion research: Findings from 2000 to 2022".
  1. Cureus. 2023 Dec;15(12): e50959
    Bibliometric Evaluation of the 100 Top-Cited Articles on Anesthesiology.
    Rakan Khalid Alfouzan, Pillai Arun Gopinathan, Ikram Ui Haq, Kiran Iyer, Azzam Abdullaziz Nawab, Abdullah Alhumaidan.
      This review is a bibliometric analysis based on anesthesiology, which is a medical specialty that deals with a patient's complete preoperative, intraoperative, and postoperative care. The objective of the review attempts to analyze the bibliometric characteristics of the 100 most top-cited articles on anesthesiology. The meta-data of the study were collected from the Core Collection of Web of Science database. A title search option was employed, and "Anesthesia" and "Anesthesiology" were typed in two different search boxes separated with the Boolean operator ''OR''. Further, the data were sorted by highest citation order; later, "article" was selected from the filter of document type, and all other types of documents were excluded. Finally, downloaded the bibliographic details of the 100 top-cited articles. VOSviewer Software (version 1.6.10 by van Eck and Waltman) was used for bibliometric network analysis for co-authors and keywords. Pearson chi-square test was used for statistical analysis. The 100 top-cited articles were published between the years of 1971 and 2018. These articles gained a maximum of 1006 to a minimum of 276 citations with an average of 384.57 cites/article. Open accessed articles gained a slightly higher ratio of citations, while more than half of the articles were published in the two leading journals of "Anesthesiology" and "Anesthesia and Analgesia". There was no statistically significant difference in both citation analysis among open and closed access journals and Anesthesia vs Non-Anesthesia journals. Thirty-six articles were published in journals not specifically related to Anesthesia. Most of the top-cited articles were contributed by the United States, whereas Surgery and General Anesthesia were the two most occurred keywords.  We conclude that all the top-cited articles in anesthesiology were contributed by authors who belonged to the developed nations and the United States outclassed the rest of the world. This bibliometric analysis would be valuable to practitioners, academics, researchers, and students to understand the dynamics of progress in the field of anesthesiology.
    Keywords:  anesthesia; bibliometric analysis; citations; research productivity; vosviewer
    DOI:  https://doi.org/10.7759/cureus.50959
  2. Front Neurol. 2023 ;14 1280908
    A bibliometric analysis of the research hotspots and frontiers related to cell death in spinal cord injury.
    Kelin He, Han Yu, Jieqi Zhang, Lei Wu, Dexiong Han, Ruijie Ma.
       Background: Spinal cord injury (SCI) is a severe central nervous trauma that can cause serious consequences. Cell death is emerging as a common pathogenesis after SCI. In the last two decades, numerous studies have been published in the field of cell death after SCI. However, it is still rare to find relevant bibliometric analyses. This bibliometric study aims to visually represent global research trends in the field of cell death after SCI.
    Methods: Bibliometric data were sourced from the Web of Science Core Collection (WoSCC) database. VOSviewer, CiteSpace, and R software ("bibliometrix" package) were used to analyze and visualize bibliometric data. Annual scientific production, countries/regions, institutions, authors, journals, highly cited papers, keywords, and literature co-citation were evaluated to determine research performance.
    Results: An analysis of 5,078 publications extracted from the WoSCC database revealed a fluctuating yet persistent growth in the field of cell death after SCI over the past 23 years. China and the United States, contributing 69% of the total publications, were the main driving force in this field. The Wenzhou Medical University from China contributed to the most papers. In terms of authors, Salvatore Cuzzocrea from the University of Messina had the highest number of publications. The "Journal of Neurotrauma" was the top journal in terms of the number of publications, however, the "Journal of Neuroscience" was the top journal in terms of the number of citations. The theme of the highly cited articles mainly focused on the mechanism of cell death after SCI. The keyword and literature co-citation analysis mainly focused on the mode of cell death, mechanism research of cell death, and functional recovery after SCI.
    Conclusion: This study analyzes the research hotspots, frontiers, and development trends in the field of cell death after SCI, which is important for future studies.
    Keywords:  apoptosis; bibliometric analysis; cell death; research hotspots; spinal cord injury
    DOI:  https://doi.org/10.3389/fneur.2023.1280908
  3. Front Immunol. 2023 ;14 1328103
    Knowledge mapping of immunotherapy in cervical carcinoma: a bibliometric analysis (2000-2023).
    Ling Song, Xinmei Liang, Min Zhu, Qiang Su, Fengzhou Li.
       Background: Cervical carcinoma is a type of malignant tumor that primarily develops in the cervix, the lower part of the uterus. In recent years, Despite the considerable progress made in immunotherapy research for cervical carcinoma, an important aspect has been largely overlooked - the absence of a comprehensive bibliometric analysis in this field. By employing bibliometric techniques, this study aims to fill this gap and provide a comprehensive overview of the knowledge structure and research hotspots within the realm of immunotherapy in cervical carcinoma.
    Method: A comprehensive search was conducted on the web of science core collection(WoSCC) database to identify publications related to immunotherapy specifically for the treatment of cervical carcinoma. The search spanned the period from the year 2000 to 2023. Several analytical tools were employed. These included VOSviewers, CiteSpace, and the R package "bibliometrix".
    Results: A total of 654 research articles from 66 different countries have been included in the analysis. The United States and China have emerged as the leading countries in publishing research on immunotherapy in cervical carcinoma. Leiden University and Memorial Sloan-Kettering Cancer Center from the Netherlands and the United States respectively have a close cooperation. Fudan University from China and the German Cancer Research Center are also among the key institutions leading research in this area. Frontiers in Oncology has emerged as the most popular and widely recognized publication in the field of immunotherapy in cervical carcinoma. Journal of Clinical Oncology is frequently cited by researchers in this area. Van Der Burg, Sjoerd H has published the highest number of papers. Tewari, Krishnansu S has been the most co-cited author. Keywords such as PD-L1, chemotherapy, and immune checkpoint inhibitors have gained significant attention in recent years.
    Conclusion: This is the first bibliometric study that comprehensively summarizes the research trends and developments of immunotherapy in cervical carcinoma. This groundbreaking study not only summarizes the current research trends and developments in immunotherapy for cervical carcinoma but also provides a reference for scholars studying the treatment of cervical cancer.
    Keywords:  CiteSpace; VOSviewers; bibliometric analysis; cervical carcinoma; immunotherapy
    DOI:  https://doi.org/10.3389/fimmu.2023.1328103
  4. J Craniovertebr Junction Spine. 2023 Oct-Dec;14(4):14(4): 346-364
    Traumatic spinal cord and spinal column injuries: A bibliometric analysis of the 200 most cited articles.
    Georgios Mavrovounis, Marios Makris, Andreas K Demetriades.
       Study Design: Bibliometric analysis.
    Objectives: This study aimed to highlight the 200 most influential articles related to traumatic spinal cord and spinal column injuries and provide an insight of past and current global trends in spinal trauma research.
    Methods: The Web of Science database was used to identify the top 200 most cited articles on the topic of traumatic spinal cord injury (SCI) and spinal column injuries between using a prespecified algorithm. The articles were manually reviewed; bibliometrics were collected on title, first and corresponding authors' country, institution, journal, publication year, and citation data.
    Results: The search string yielded 30,551 articles during 1977-2019. The average time from the publication was 19.5 years. A total of 1356 authors contributed to 67 different journals, the top 200 most cited articles amassing a total of 88,115 citations and an average 440.6 citations. The United States of America (USA) contributed the most with 110 articles; the top institution was the University of Toronto with 34 publications. Most studies focused on basic science research on SCI. Keyword analysis revealed the most commonly used keywords: SCI, inflammation, apoptosis, incidence/prevalence, and regeneration; four word-clusters were identified. Institutions from the USA and Canada collaborated the most and two major and two minor institutional collaboration subnetworks were identified. Co-citation analysis detected three main clusters of authors.
    Conclusion: This overview of the most cited articles on traumatic spinal cord and spinal column injuries provides insight into the international spinal trauma community and the terrain in this field, potentially acting as a springboard for further collaboration development.
    Keywords:  Bibliometric; spinal column injury; spinal cord injury; spinal injury; spinal trauma
    DOI:  https://doi.org/10.4103/jcvjs.jcvjs_97_23
  5. Immun Inflamm Dis. 2024 Jan;12(1): e1156
    Bibliometric analysis of mucosal immunity in IgA nephropathy from 1990 to 2022.
    Xian Chen, Zhe Yan, Qing Pan, Chunxia Zhang, Yakun Chen, Xuzhi Liang, Shaomei Li, Gang Wu.
       OBJECTIVE: The study aimed to conduct a bibliometric analysis of mucosal immunity in IgA nephropathy (IgAN) and indicate its current status, hot sopts, and direction of future studies.
    METHODS: The literature data was collected from the Web of Science Core Collection. CiteSpace 6.1.R3 was employed to conduct a visualization bibliometric analysis of mucosal immunity in IgA nephropathy, including authors, countries, journals, keywords, organizations, references, the bursts of keywords and references, and the timeline of keyword clusters and reference clusters.
    RESULTS: A total of 315 publications from 1990 to 2022 were included. The number of articles in this field has increased in recent years. Suzuki H, Coppo R, and Feehally J took the first place parallelly with 18 articles. Japan contributes the most articles, accounting for 27.3% of all the publications. The institutions with the most publications were Juntendo University and University of Alabama Birmingham. 453 keywords were concluded in the analysis, which mainly focus on the mucosal pathogenesis and therapy of the IgAN. The top five co-cited reference cluster are "aberrantly glycosylated IgA," "corticosteroids," "animal models," "o-glycosylationm" and "microRNA-630." The most recently burst of keyword is "tonsillectomy" and "gut."
    CONCLUSION: This was the first bibliometric analysis to systematically analyze the mucosal immunity in IgAN, which obtained the current status and indicated the future research hotspots and development trends. The gut microbiota and the related therapy-targeted mucosal immunity might be the future research hotspot.
    Keywords:  CiteSpace; IgA nephropathy; bibliometric analysis; gut microbiota; mucosal immunity
    DOI:  https://doi.org/10.1002/iid3.1156
  6. Front Neurol. 2023 ;14 1327915
    Current perspectives and trends in the treatment of brain arteriovenous malformations: a review and bibliometric analysis.
    Weixia Tang, Yang Chen, Li Ma, Yu Chen, Biao Yang, Ren Li, Ziao Li, Yongqiang Wu, Xiaogang Wang, Xiaolong Guo, Wenju Zhang, Xiaolin Chen, Ming Lv, Yuanli Zhao, Geng Guo.
       Background: Currently, there is a lack of intuitive analysis regarding the development trend, main authors, and research hotspots in the field of cerebral arteriovenous malformation treatment, as well as a detailed elaboration of possible research hotspots.
    Methods: A bibliometric analysis was conducted on data retrieved from the Web of Science core collection database between 2000 and 2022. The analysis was performed using R, VOSviewer, CiteSpace software, and an online bibliometric platform.
    Results: A total of 1,356 articles were collected, and the number of publications has increased over time. The United States and the University of Pittsburgh are the most prolific countries and institutions in the field. The top three cited authors are Kondziolka D, Sheehan JP, and Lunsford LD. The Journal of Neurosurgery and Neurosurgery are two of the most influential journals in the field of brain arteriovenous malformation treatment research, with higher H-index, total citations, and number of publications. Furthermore, the analysis of keywords indicates that "aruba trial," "randomised trial," "microsurgery," "onyx embolization," and "Spetzler-Martin grade" may become research focal points. Additionally, this paper discusses the current research status, existing issues, and potential future research directions for the treatment of brain arteriovenous malformations.
    Conclusion: This bibliometric study comprehensively analyses the publication trend of cerebral arteriovenous malformation treatment in the past 20 years. It covers the trend of international cooperation, publications, and research hotspots. This information provides an important reference for scholars to further study cerebral arteriovenous malformation.
    Keywords:  arteriovenous malformations; bibliometrics; embolization; microsurgery; radiosurgery; therapeutic
    DOI:  https://doi.org/10.3389/fneur.2023.1327915
  7. World Neurosurg. 2024 Jan 18. pii: S1878-8750(24)00071-8. [Epub ahead of print]
    Contributions of Machine Learning in the Management of Stroke: A Bibliometric analysis of the 50 most cited articles.
    Bhavya Pahwa, Anish Tayal, Kanwaljeet Garg.
       BACKGROUND: Though currently considered a 'black box,' machine learning (ML) has a promising future to ameliorate the healthcare burden of stroke which is the second leading cause of mortality worldwide. Through this study, we sought to review the most influential articles on the applications of ML in stroke.
    METHOD: ology: Web of Sciences database was searched, and a list of the top 50 most cited articles, assessing the application of ML in stroke, was prepared by two authors, independently. Subsequently, a detailed analysis was performed to characterize the most impactful studies.
    RESULTS: The total number of citations to the top 50 articles were 2959 (range 35 to 243 citations) with a median of 47 citations. Highest number of articles were published in the journal Stroke and the USA was the major contributing country. The majority of the studies focused on the utilization of ML to improve stroke risk prediction, diagnosis, and outcome prediction. Statistical analysis revealed an insignificant association between the total and mean number of citations and the impact factor of the journal (p = 0.516 and 0.987, respectively).
    CONCLUSION: Recent years have witnessed a surge in the application of ML in stroke, with an enhancement in interest and funding over the years. ML has revolutionized the management of stroke and continues to aid in the neurosurgical decision-making and care in stroke patients.
    Keywords:  Bibliometric analysis; machine learning; outcome prediction; risk prediction; stroke
    DOI:  https://doi.org/10.1016/j.wneu.2024.01.059
  8. Front Artif Intell. 2023 ;6 1270749
    The scholarly footprint of ChatGPT: a bibliometric analysis of the early outbreak phase.
    Faiza Farhat, Emmanuel Sirimal Silva, Hossein Hassani, Dag Øivind Madsen, Shahab Saquib Sohail, Yassine Himeur, M Afshar Alam, Aasim Zafar.
      This paper presents a comprehensive analysis of the scholarly footprint of ChatGPT, an AI language model, using bibliometric and scientometric methods. The study zooms in on the early outbreak phase from when ChatGPT was launched in November 2022 to early June 2023. It aims to understand the evolution of research output, citation patterns, collaborative networks, application domains, and future research directions related to ChatGPT. By retrieving data from the Scopus database, 533 relevant articles were identified for analysis. The findings reveal the prominent publication venues, influential authors, and countries contributing to ChatGPT research. Collaborative networks among researchers and institutions are visualized, highlighting patterns of co-authorship. The application domains of ChatGPT, such as customer support and content generation, are examined. Moreover, the study identifies emerging keywords and potential research areas for future exploration. The methodology employed includes data extraction, bibliometric analysis using various indicators, and visualization techniques such as Sankey diagrams. The analysis provides valuable insights into ChatGPT's early footprint in academia and offers researchers guidance for further advancements. This study stimulates discussions, collaborations, and innovations to enhance ChatGPT's capabilities and impact across domains.
    Keywords:  ChatGPT; application domains; bibliometric analysis; citation analysis; collaborative networks; future directions; research trends; scientometric methods
    DOI:  https://doi.org/10.3389/frai.2023.1270749
  9. Ocul Immunol Inflamm. 2024 Jan 22. 1-10
    A Bibliometric Analysis of Uveitis in the Past 20 Years.
    Yuhong Chen, Yimin Wang, Xiaohuan Zhao, Huimin Zhong, Ke Shi, Xiaoxu Huang, Feng Lin, Minyue Xie, Hong Wang, Xiaodong Sun.
       PURPOSE: To assess the quantity and quality of global research on uveitis, visualize the research hotspots, and reveal the study trends in uveitis.
    METHODS: This bibliometric analysis was performed with the data obtained from the Web of Science core collection (WoSCC) database and Scopus. Bibliometrix and VOSviewer were used to analyze and visualize study trends and hotspots. Citespace was used to conduct the cooperation and co-citation network analysis.
    RESULTS: A total of 5837 and 7195 documents were exported for further analysis in WoSCC and Scopus, respectively. The USA has published the most articles related to uveitis (1627, 27.87%, WoS; 1979, 27.51%, Scopus) and accounted for the most frequency of total citations (42345 times total citations 35 900 times without self-citations in WoSCC database). Most of the papers focusing on uveitis were published in Ocular Immunology and Inflammation (761, 13.04% within WoS; 793, 11.02% within Scopus). Additionally, novel biotherapy is the hotspot of uveitis research which also may be a sustained research interest in the future.
    CONCLUSIONS: An increasing trend of publications was found in uveitis research. The USA was the leading contributor in this field, and it was the center of cooperation network. Our study provided an overview of uveitis research, which may serve as a valuable reference and guide for stakeholders interested in uveitis.
    Keywords:  Bibliometric analysis; Citespace; Scopus; uveitis; web of science
    DOI:  https://doi.org/10.1080/09273948.2023.2295545
  10. Arthrosc Sports Med Rehabil. 2024 Feb;6(1): 100859
    Top 50 Most-Cited Studies about Osteochondritis Dissecans.
    Nicholas D Thomas, Raegan Mahler, Kylie Krombholz, Brendan Williams, Ted Ganley, Jeffrey J Nepple, Kevin Shea.
       Purpose: To determine the 50 most frequently cited studies on osteochondritis dissecans (OCD) and to conduct a bibliometric analysis of these studies.
    Methods: We performed a search within the Clarivate Web of Science database, identifying articles published before December 2022 that encompass topics related to OCD. The search was conducted using the keywords "Osteochondritis Dissecans OR Osteochondritis OR Dissecans."Search results were then filtered using predetermined guidelines and criteria, and the 50 most-cited articles were selected for analysis. Extracted data included title, journal, design, main topic, joint, citations, year, country of origin, and level of evidence.
    Results: The search yielded 3,865 articles. The 50 most-cited articles were published between 1957 and 2018, with the greatest proportion published from 2000 to 2009 (60%). The most frequently studied topic was treatment (68%), followed by etiology (14%) and imaging (8%). The majority of articles had Level IV evidence (36%) and the largest proportion focused on the knee joint (36%), followed by the ankle (32%), and elbow (6%). The mean citation count per article was 287 (range: 157-1,050), with the most-cited articles primarily published from 2000 to 2003. The leading country of origin was the United States, accounting for 19 publications.
    Conclusions: Most of the top 50 most-cited articles regarding OCD are about treatment, and the knee is the most-studied joint. The majority of the articles were Level IV evidence and were published in the United States between 2000 and 2009.
    Clinical Relevance: The top 50 most-cited studies list will provide researchers, medical students, residents, and fellows with a foundational list of the most important and influential academic contributions regarding osteochondritis dissecans (OCD).
    DOI:  https://doi.org/10.1016/j.asmr.2023.100859
  11. Eur J Med Res. 2024 Jan 24. 29(1): 75
    Hotspots and trends of microglia in Alzheimer's disease: a bibliometric analysis during 2000-2022.
    Lijie Zhang, Qiuru Yao, Jinjing Hu, Baizhi Qiu, Yupeng Xiao, Qi Zhang, Yuting Zeng, Shuqi Zheng, Youao Zhang, Yantong Wan, Xiaoyan Zheng, Qing Zeng.
       BACKGROUND: Alzheimer's disease is one common type of dementia. Numerous studies have suggested a correlation between Alzheimer's disease and inflammation. Microglia mainly participate in the inflammatory response in the brain. Currently, ample evidence has shown that microglia are closely related to the occurrence and development of Alzheimer's disease.
    OBJECTIVE: We opted for bibliometric analysis to comprehensively summarize the advancements in the study of microglia in Alzheimer's disease, aiming to provide researchers with current trends and future research directions.
    METHODS: All articles and reviews pertaining to microglia in Alzheimer's disease from 2000 to 2022 were downloaded through Web of Science Core Collection. The results were subjected to bibliometric analysis using VOSviewer 1.6.18 and CiteSpace 6.1 R2.
    RESULTS: Overall, 7449 publications were included. The number of publications was increasing yearly. The United States has published the most publications. Harvard Medical School has published the most papers of all institutions. Journal of Alzheimer's Disease and Journal of Neuroscience were the journals with the most studies and the most commonly cited, respectively. Mt Heneka is the author with the highest productivity and co-citation. After analysis, the most common keywords are neuroinflammation, amyloid-beta, inflammation, neurodegeneration. Gut microbiota, extracellular vesicle, dysfunction and meta-analysis are the hotspots of research at the present stage and are likely to continue.
    CONCLUSION: NLRP3 inflammasome, TREM2, gut microbiota, mitochondrial dysfunction, exosomes are research hotspots. The relationship between microglia-mediated neuroinflammation and Alzheimer's disease have been the focus of current research and the development trend of future research.
    Keywords:  Alzheimer’s disease; Bibliometrics; CiteSpace; Microglia; VOSviewer
    DOI:  https://doi.org/10.1186/s40001-023-01602-9
  12. Int Wound J. 2024 Jan;21(1): e14559
    Global research status of localised scleroderma reported over the period 1993-2022: A 30-year bibliometric analysis.
    Zi-Ming Li, Tian-Hao Li, Zhu-Jun Li, Li-Quan Wang, Xiao Long, Jiu-Zuo Huang.
      Localised scleroderma predominantly affects the skin with an unknown aetiology. Despite its clinical importance, no comprehensive bibliometric analysis has been conducted to assess the existing research landscape and future prospects for localised scleroderma. The articles related to localised scleroderma were retrieved from the WoSCC database and analysed by VOSviewer 1.6.10.0 (Leiden University, Netherlands), CiteSpace 6.1.R1 (Dreiser University, USA), and HistCite 2.1 (New York, United States). 2049 research papers pertaining to localised scleroderma spanning the years from 1993 to 2022 were extracted from the WoSCC database. The United States exhibited the highest productivity with 644 papers, accounting for 31.43% of the total output, followed by Germany with 206 papers (10.05%) and Italy with 200 papers (9.76%). Regarding academic institutions and journals, the University of Texas System and Dermatology published the most significant number of papers, and Professor Ihn, H emerged as the most prolific contributor among scholars. The top 10 cited references primarily concentrated on the diagnosis and treatment of localised scleroderma. "Phototherapy" and "methotrexate (MTX)" surfaced as the most recent and noteworthy keywords, representing the research hotspots in the domain of localised scleroderma. This bibliometric analysis furnishes valuable insights into the contemporary research landscape of localised scleroderma.
    Keywords:  CiteSpace; VOSviewer; bibliometric analysis; localised scleroderma; research hotspots
    DOI:  https://doi.org/10.1111/iwj.14559
  13. Ren Fail. 2024 Dec;46(1): 2302963
    The relationship between kidney disease and mitochondria: a bibliometric study.
    Jueyi Mao, Cuifang Li, Feifeng Wu, Yang Wang, Junquan Zhu, Chuan Wen.
       BACKGROUND: Due to its highly reabsorptive function, the kidney is a mitochondria-dependent organ. Research on the association between mitochondria and kidney disease has always been a serious focus of researchers, with many publications. Bibliometrics is a secondary analysis of published literature that extracts relevant information to gain insights into hotspots and trends in the field. Through bibliometric analysis, we aimed to understand the development trends and hotspots in the field of research on the association between kidney disease and mitochondria.
    METHOD: Three bibliometric mapping tools (Biblimetrix R Package, VOS Viewer, CiteSpace) were used to provide an overview of the literature and analyze the co-occurrence of keywords and reference citations.
    RESULTS: A total of 2672 relevant research articles were included. The co-occurrence network identified three clusters related to the association between mitochondria and kidney disease, including experimental methods, research mechanisms, and disease phenotypes. We found that research in this field has shifted from disease-level studies to mechanism-based studies, with the most prominent disease being diabetic nephropathy and the most prominent pathogenic mechanism being related to mitochondrial ROS production.
    CONCLUSION: The bibliometric analysis provided a comprehensive understanding of the progress of research on the role of mitochondria in kidney disease, enriching the review literature in this field.
    Keywords:  Mitochondria; bibliometrics; kidney diseases
    DOI:  https://doi.org/10.1080/0886022X.2024.2302963
  14. Front Pharmacol. 2023 ;14 1333124
    Unveiling the landscape of cytokine research in glioma immunotherapy: a scientometrics analysis.
    Hongyu Zhang, Ying Chen, Xinzhan Jiang, Qiang Gu, Jiahao Yao, Xuefeng Wang, Jianghua Wu.
      Background: Cytokines modulate the glioma tumor microenvironment, influencing occurrence, progression, and treatment response. Strategic cytokine application may improve glioma immunotherapy outcomes. Gliomas remain refractory to standard therapeutic modalities, but immunotherapy shows promise given the integral immunomodulatory roles of cytokines. However, systematic evaluation of cytokine glioma immunotherapy research is absent. Bibliometric mapping of the research landscape, recognition of impactful contributions, and elucidation of evolutive trajectories and hot topics has yet to occur, potentially guiding future efforts. Here, we analyzed the structure, evolution, trends, and hotspots of the cytokine glioma immunotherapy research field, subsequently focusing on avenues for future investigation. Methods: This investigation conducted comprehensive bibliometric analyses on a corpus of 1529 English-language publications, from 1 January 2000, to 4 October 2023, extracted from the Web of Science database. The study employed tools including Microsoft Excel, Origin, VOSviewer, CiteSpace, and the Bibliometrix R package, to systematically assess trends in publication, contributions from various countries, institutions, authors, and journals, as well as to examine literature co-citation and keyword distributions within the domain of cytokines for glioma immunotherapy. The application of these methodologies facilitated a detailed exploration of the hotspots, the underlying knowledge structure, and the developments in the field of cytokines for glioma immunotherapy. Results: This bibliometric analysis revealed an exponential growth in annual publications, with the United States, China, and Germany as top contributors. Reviews constituted 17% and research articles 83% of total publications. Analysis of keywords like "interleukin-13," "TGF-beta," and "dendritic cells" indicated progression from foundational cytokine therapies to sophisticated understanding of the tumor microenvironment and immune dynamics. Key research avenues encompassed the tumor microenvironment, epidermal growth factor receptor, clinical trials, and interleukin pathways. This comprehensive quantitative mapping of the glioma immunotherapy cytokine literature provides valuable insights to advance future research and therapeutic development. Conclusion: This study has identified remaining knowledge gaps regarding the role of cytokines in glioma immunotherapy. Future research will likely focus on the tumor microenvironment, cancer vaccines, epidermal growth factor receptor, and interleukin-13 receptor alpha 2. Glioma immunotherapy development will continue through investigations into resistance mechanisms, microglia and macrophage biology, and interactions within the complex tumor microenvironment.
    Keywords:  VOSviewer; citespace; cytokine; glioma; immune microenvironment; immunotherapy; scientometrics
    DOI:  https://doi.org/10.3389/fphar.2023.1333124
  15. Front Neurosci. 2023 ;17 1343471
    Research hotspots and frontiers of neuromodulation techniques in disorders of consciousness: a bibliometric analysis.
    Bilian Guo, Qiong Han, Jun Ni, Zhipeng Yan.
       Background: The characteristics of disorders of consciousness (DOC) are changes in arousal and/or awareness caused by severe brain injuries. To date, the management of DOC patients remains a complex and challenging task, and neuromodulation techniques offer a promising solution. However, a bibliometric analysis focusing on neuromodulation techniques in DOC is currently absent. The aim of this study is to provide a bibliometric visualization analysis to investigate the research hotspots and frontiers in the field of neuromodulation techniques in DOC from 2012 to 2022.
    Methods: The publications were collected and retrieved from the Web of Science (WoS) from 2012 to 2022. CiteSpace and Microsoft Excel were utilized perform the first global bibliographic analysis of the literature related to neuromodulation techniques for DOC.
    Results: The analysis included a total of 338 publications. From 2012 to 2022, a consistent yet irregular increase in the number of articles published on neuromodulation techniques in DOC was observed. Frontiers in Neurology published the highest number of papers (n = 16). Neurosciences represented the main research hotspot category (n = 170). The most prolific country, institution, and author were the USA (n = 105), the University of Liege (n = 41), and Laureys Steven (n = 38), respectively. An analysis of keywords revealed that UWS/VS, MCS, and TMS constituted the primary research trends and focal points within this domain.
    Conclusion: This bibliometric study sheds light on the current progress and emerging trends of neuromodulation techniques in DOC from 2012 to 2022. The focal topics in this domain encompass the precise diagnosis of consciousness levels in patients suffering from DOC and the pursuit of efficacious neuromodulation-based evaluation and treatment protocols for such patients.
    Keywords:  CiteSpace; Web of Science; bibliometrics; disorders of consciousness; neuromodulation techniques
    DOI:  https://doi.org/10.3389/fnins.2023.1343471
  16. Skin Res Technol. 2024 Feb;30(2): e13595
    Global research trends in cutaneous neurofibromas: A bibliometric analysis from 2003 to 2022.
    Jiani Wang, Jie Fu, Yu Zhou, Dongmei Gao, Jihong Qing, Guoke Yang.
       BACKGROUND: Neurofibromatosis type 1 (NF1) is a common inherited disorder characterized by cutaneous neurofibromas and other features. It is still a challenge in managing inoperable patients and the complex nature of the disease. Bibliometric analyses for cutaneous neurofibromas (cNF) could offer insights into impactful research and collaborations, guiding future efforts to improve patient care and outcomes.
    METHODS: We conducted a comprehensive literature search of the Web of Science Core Collection database for the period 2003-2022. Data processing and analysis were performed using bibliometric tools including VOSviewer, CiteSpace, and "Bibliometrix" package. Our analysis assessed the publication or collaboration of countries, institutions, authors, and journals, as well as the co-citation and burst of references and keywords.
    RESULTS: The analysis included 927 articles from 465 journals and 1402 institutions in 67 countries. Research on cNF has been increasing in recent years. The United States leads the field. Pierre Wolkenstein was the top author, while The University of Hamburg was the most productive institution. The American Journal of Medical Genetics Part A published the most articles in cNF. Co-citation analysis revealed major research topics and trends over time, showing growing interest in evaluating quality of life and genotype-phenotype correlation for cNF patients. Emerging topical MEK inhibitors show potential as a promising therapy.
    CONCLUSION: In conclusion, our bibliometric analysis of cNF research over the past two decades highlights the growing interest in this complex genetic disorder. Leading countries, authors, institutions, and journals have played significant roles in shaping the field. Notably, recent trends emphasize the importance of evaluating quality of life and genotype-phenotype correlations in cNF patients. Furthermore, the emergence of promising topical therapy marks an exciting development in the quest to improve patient care and outcomes for those affected by cNF, paving the way for future research and collaboration.
    Keywords:  bibliometircs; citespace; cutaneous neurofibroma; skin benign tumor; vosviewer
    DOI:  https://doi.org/10.1111/srt.13595
  17. Front Genet. 2023 ;14 1285599
    Bibliometric and visual analysis of single-cell sequencing from 2010 to 2022.
    Ling Chen, Yantong Wan, Tingting Yang, Qi Zhang, Yuting Zeng, Shuqi Zheng, Zhishan Ling, Yupeng Xiao, Qingyi Wan, Ruili Liu, Chun Yang, Guozhi Huang, Qing Zeng.
      Background: Single-cell sequencing (SCS) is a technique used to analyze the genome, transcriptome, epigenome, and other genetic data at the level of a single cell. The procedure is commonly utilized in multiple fields, including neurobiology, immunology, and microbiology, and has emerged as a key focus of life science research. However, a thorough and impartial analysis of the existing state and trends of SCS-related research is lacking. The current study aimed to map the development trends of studies on SCS during the years 2010-2022 through bibliometric software. Methods: Pertinent papers on SCS from 2010 to 2022 were obtained using the Web of Science Core Collection. Research categories, nations/institutions, authors/co-cited authors, journals/co-cited journals, co-cited references, and keywords were analyzed using VOSviewer, the R package "bibliometric", and CiteSpace. Results: The bibliometric analysis included 9,929 papers published between 2010 and 2022, and showed a consistent increase in the quantity of papers each year. The United States was the source of the highest quantity of articles and citations in this field. The majority of articles were published in the periodical Nature Communications. Butler A was the most frequently quoted author on this topic, and his article "Integrating single-cell transcriptome data across diverse conditions, technologies, and species" has received numerous citations to date. The literature and keyword analysis showed that studies involving single-cell RNA sequencing (scRNA-seq) were prominent in this discipline during the study period. Conclusion: This study utilized bibliometric techniques to visualize research in SCS-related domains, which facilitated the identification of emerging patterns and future directions in the field. Current hot topics in SCS research include COVID-19, tumor microenvironment, scRNA-seq, and neuroscience. Our results are significant for scholars seeking to identify key issues and generate new research ideas.
    Keywords:  CiteSpace; VOSviewer; bibliometric; single-cell sequencing; visual analysis
    DOI:  https://doi.org/10.3389/fgene.2023.1285599
  18. J Anesth Analg Crit Care. 2024 Jan 24. 4(1): 5
    Bridging knowledge gaps: a bibliometric analysis of non-invasive ventilation in palliative care studies.
    Marco Cascella, Federica Monaco, Alessandro Vittori, Mostafa Elshazly, Annalisa Carlucci, Ornella Piazza.
       BACKGROUND: Despite being a useful strategy for providing respiratory support to patients with advanced or terminal illnesses, non-invasive ventilation (NIV) requires in-depth investigation in several key aspects.
    OBJECTIVES: This bibliometric analysis seeks to comprehensively examine the existing research on the subject. Its goal is to uncover valuable insights that can inform the prediction trajectory of studies, guide the implementation of corrective measures, and contribute to the improvement of research networks.
    METHODS: A comprehensive review of literature on NIV in the context of palliative care was conducted using the Web of Science core collection online database. The search utilized the key terms "non-invasive ventilation" and "palliative care" to identify the most relevant articles. All data were gathered on November 7, 2023. Relevant information from documents meeting the specified criteria was extracted, and Journal Citation Reports™ 2022 (Clarivate Analytics) served as the data source. The analysis employed literature analysis and knowledge visualization tools, specifically CiteScope (version 6.2.R4) and VOSviewer (version 1.6.20).
    RESULTS: A dataset with bibliometric findings from 192 items was analyzed. We found a consistent upward of the scientific output trend over time. Guidelines on amyotrophic lateral sclerosis management received the highest number of citations. Most documents were published in top-ranked journals. Less than one-third of the documents pertain to clinical studies, especially retrospective analyses (25%). Key topics such as "decision making", and "communication" were less addressed.
    CONCLUSIONS: Given the substantial clinical implications, further high-quality studies on this subject are recommended. Encouraging international collaborations is needed. Despite the growing volume of documents in the field, this bibliometric analysis indicates a decline in collaborative networks.
    Keywords:  Amyotrophic lateral sclerosis; Bibliometrics; Cancer; CiteSpace; Non-invasive ventilation; Palliative care; Specialized palliative care; VOSviewer
    DOI:  https://doi.org/10.1186/s44158-024-00140-y
  19. Arq Neuropsiquiatr. 2024 Jan;82(1): 1-10
    Repercussions of the Emergency neurological life support on scientific literature: a bibliometric study.
    Miguel Bertelli Ramos, Matheus Machado Rech, João Paulo Mota Telles, Willian Medeiros Moraes, Manoel Jacobsen Teixeira, Eberval Gadelha Figueiredo.
       BACKGROUND:  In 2012, the Neurocritical Care Society launched a compilation of protocols regarding the core issues that should be addressed within the first hours of neurological emergencies - the Emergency neurological life support (ENLS).
    OBJECTIVE:  We aim to evaluate this repercussion through a bibliometric analysis.
    METHODS:  We searched Scopus on October 2022 for articles mentioning ENLS. The following variables were obtained: number of citations; number of citations per year; number of publications per year; year of publication; research type; research subtype; country of corresponding author and its income category and world region; journal of publication and its 5-year impact factor (IF); and section where ENLS appeared.
    RESULTS:  After applying eligibility criteria, we retrieved 421 articles, published from 2012 to 2022. The mean number of citations per article was 17.46 (95% Confidence Interval (CI) = 8.20-26.72), while the mean number of citations per year per article was 4.05 (95% CI = 2.50-5.61). The mean destiny journal 5-year IF was 5.141 (95% CI = 4.189-6.093). The majority of articles were secondary research (57.48%; n = 242/421) of which most were narrative reviews (71.90%; n = 174/242). High-Income countries were the most prominent (80.05%; n = 337/421 articles). There were no papers from low-income countries. There were no trials or systematic reviews from middle-income countries.
    CONCLUSION:  Although still low, the number of publications mentioning ENLS is increasing. Articles were mainly published in journals of intensive care medicine, neurology, neurosurgery, and emergency medicine. Most articles were published by authors from high-income countries. The majority of papers were secondary research, with narrative review as the most frequent subtype.
    DOI:  https://doi.org/10.1055/s-0043-1777110
  20. Braz J Microbiol. 2024 Jan 23.
    Current global status of Candida auris an emerging multidrug-resistant fungal pathogen: bibliometric analysis and network visualization.
    Hamza Ettadili, Caner Vural.
       BACKGROUND: Candida auris is an emerging multidrug-resistant fungal pathogen associated with nosocomial infections and hospital outbreaks worldwide, presenting a serious global health threat. There has been a rapid emergence of scientific research publications focusing on therapeutic compounds, diagnostic techniques, control strategies, prevention, and understanding the epidemiology related to C. auris.
    OBJECTIVE: This study aims to provide the most up-to-date comprehensive and integrated examination of C. auris research subject and demonstrate that C. auris is indeed a topic of increasing interest.
    METHODS: The search query "candida-auris" was used as a topic term to find and retrieve relevant data published between 2009 and 15 June 2023, from the Web of Science Core Collection (WoSCC) database. In this work, the bibliometric analysis and network visualization were conducted using VOSviewer software, and Biblioshiny interface accessible through the Bibliometrix R-package on RStudio software.
    RESULTS: The yearly growth rate percentage (37.91%), along with the strong positive correlations between publications and citations (r = 0.981; p < 0.001), suggests heightened scholarly engagement in this topic. The USA, India, China, and the UK have emerged as pivotal contributors, with the Centers for Disease Control and Prevention (CDC) in the USA being the most productive institution. Current research hotspots in this field mainly focused on identifying and limiting transmission of the clonal strains, epidemiology, antifungal resistance, and in vitro antifungal susceptibility testing.
    CONCLUSION: This detailed bibliometric analysis in C. auris topic shows that this fungal pathogen has garnered growing attention and attracted progressively more scholars. This paper will help researchers to find without difficulty the relevant articles, research hotspots, influential authors, institutions, and countries related to the topic.
    Keywords:  Bibliometrics; Candida auris; Candidiasis; Fungal pathogen; R-bibliometrix; Responsible Editor: Rosana Puccia; VOSviewer
    DOI:  https://doi.org/10.1007/s42770-023-01239-0
  21. Front Neurol. 2023 ;14 1334360
    Research landscape and trends of cerebral amyloid angiopathy: a 25-year scientometric analysis.
    Kunyu Wang, Beilin Zhang, Heqian Du, Hanying Duan, Zhuoya Jiang, Shaokuan Fang.
       Background: Cerebral amyloid angiopathy (CAA), a cerebral small vessel disease affecting leptomeningeal and cortical small blood vessels, is a common cause of spontaneous lobar intracerebral hemorrhage and cognitive impairment, particularly in elderly patients. This study aims to investigate the field of CAA research from a scientometric perspective.
    Methods: Publications related to CAA from January 1st, 1999 to September 29th, 2023 were retrieved from the Web of Science Core Collection database. The scientometric software VOSviewer and CiteSpace were used to analyze and visualize the publication trends, countries/regions, institutions, authors, journals, cited references, and keywords of CAA.
    Results: A total of 2,798 publications related to CAA from 73 countries/regions, led by the United States, were included. The number of publications showed an increasing trend over time. Massachusetts General Hospital was the most productive institution, and authors Greenberg and Charidimou published the most papers and were most frequently co-cited. Journal of Alzheimer's Disease was the most prolific journal in this field, and Neurology was the most co-cited journal. Apart from "cerebral amyloid angiopathy", the most frequently used keywords were "Alzheimer's disease", "amyloid beta", "intracerebral hemorrhage", and "dementia". The burst keywords in recent years included "cortical superficial siderosis" and "dysfunction".
    Conclusions: This scientometric analysis provides a comprehensive overview of CAA research over the past 25 years, and offers important insights for future research directions and scientific decision-making in this field.
    Keywords:  CiteSpace; VOSviewer; cerebral amyloid angiopathy; scientometric analysis; trends
    DOI:  https://doi.org/10.3389/fneur.2023.1334360
  22. J Comput Assist Tomogr. 2024 Jan 16.
    Visual Knowledge Domain of Artificial Intelligence in Computed Tomography: A Review Based on Bibliometric Analysis.
    Kunshu Zhu, Zefang Shen, Min Wang, Lufang Jiang, Ye Zhang, Tiantong Yang, Haidong Zhang, Mengzhou Zhang.
       ABSTRACT: Artificial intelligence (AI)-assisted medical imaging technology is a new research area of great interest that has developed rapidly over the last decade. However, there has been no bibliometric analysis of published studies in this field. The present review focuses on AI-related studies on computed tomography imaging in the Web of Science database and uses CiteSpace and VOSviewer to generate a knowledge map and conduct the basic information analysis, co-word analysis, and co-citation analysis. A total of 7265 documents were included and the number of documents published had an overall upward trend. Scholars from the United States and China have made outstanding achievements, and there is a general lack of extensive cooperation in this field. In recent years, the research areas of great interest and difficulty have been the optimization and upgrading of algorithms, and the application of theoretical models to practical clinical applications. This review will help researchers understand the developments, research areas of great interest, and research frontiers in this field and provide reference and guidance for future studies.
    DOI:  https://doi.org/10.1097/RCT.0000000000001585
  23. Front Neurosci. 2023 ;17 1289019
    Research trend of epigenetics and depression: adolescents' research needs to strengthen.
    Dongfeng Yuan, Yitong Meng, Zhongzhu Ai, Shiquan Zhou.
       Objective: With its high prevalence, depression's pathogenesis remains unclear. Recent attention has turned to the interplay between depression and epigenetic modifications. However, quantitative bibliometric analyses are lacking. This study aims to visually analyze depression epigenetics trends, utilizing bibliometric tools, while comprehensively reviewing its epigenetic mechanisms.
    Methods: Utilizing the Web of Science core dataset, we collected depression and epigenetics-related studies. Employing VOSViewer software, we visualized data on authors, countries, journals, and keywords. A ranking table highlighted field leaders.
    Results: Analysis encompassed 3,469 depression epigenetics studies published from January 2002 to June 2023. Key findings include: (1) Gradual publication growth, peaking in 2021; (2) The United States and its research institutions leading contributions; (3) Need for enhanced collaborations, spanning international and interdisciplinary efforts; (4) Keyword clustering revealed five main themes-early-life stress, microRNA, genetics, DNA methylation, and histone acetylation-highlighting research hotspots; (5) Limited focus on adolescent depression epigenetics, warranting increased attention.
    Conclusion: Taken together, this study revealed trends and hotspots in depression epigenetics research, underscoring global collaboration, interdisciplinary fusion, and multi-omics data's importance. It discussed in detail the potential of epigenetic mechanisms in depression diagnosis and treatment, advocating increased focus on adolescent research in this field. Insights aid researchers in shaping their investigative paths toward understanding depression's epigenetic mechanisms and antidepressant interventions.
    Keywords:  VOSViewer; adolescents; bibliometrics; depression; epigenetics; research hotspots
    DOI:  https://doi.org/10.3389/fnins.2023.1289019
  24. Medicine (Baltimore). 2024 Jan 26. 103(4): e36575
    Bibliometric and visual analysis of intestinal flora and immunity.
    Kaidi Nie, Tingting Deng, Jie Wang, Luming Qi, Nannan Liu, Zhixuan Chen, Lina Xia.
       BACKGROUND: The gut microbiota and its stability have important relationships with immunity. However, bibliometric analysis in this field is underdeveloped. This study aims to visualize publications related to the gut microbiota and immunity to identify research frontiers and hotspots, providing references and guidance for further research.
    METHODS: Gut microbiota and immunity data were retrieved from the Web of Science Core Collection database, and Microsoft Excel, Scimago Graphica and VOSviewer software were used to analyze publication output trends, the most productive countries/regions, journals, authors, co-cited references, and keywords.
    RESULTS: This study analyzed 16,611 publications, including 10,865 articles and 5746 reviews, and found a continuous increase in publications related to gut microbiota and immunity since 2013. We identified 62,872 authors contributing to this field from 2144 journals and 9965 organizations/institutions in 145 countries/regions. The top publisher with the highest output is University of California System with 525 papers. Among these journals, the top 3 most prolific journals are Frontiers in Immunology, Frontiers in Microbiology, and PLOS ONE. The literature with the highest citation frequency is published in Science and has been cited 3006 times by Patrick M. Smith and others.Gut microbiota research hotspots include gut microbiota inflammation, immune response, inflammatory bowel diseases (IBDs), and microbiota tumors. The gut microbiota and its microbial homeostasis play critical roles in immune reactions, inflammation, and even tumors and IBDs.Current research on gut microbiota and immunity is a popular field. Previous studies have shown that the gut microbiota and its microbial species have important effects on maintaining human health, immune function, inflammation, tumorigenesis, and IBDs. Understanding the roles of microbial communities and specific bacterial species as well as their interactions with humans has led to numerous discoveries that provide unique opportunities for exploring human health and future research.
    CONCLUSION: This study used bibliometric and visualization analysis to identify the development trends and hotspots of publications related to the gut microbiota and immunity. The findings of this study provide valuable insights into the emerging trends and future directions in this field.
    DOI:  https://doi.org/10.1097/MD.0000000000036575
  25. Environ Sci Pollut Res Int. 2024 Jan 23.
    Bibliometric review of carbon peak with CiteSpace: evolution, trends, and framework.
    Qing Guo, Peijian Yao.
      In the context of global climate change, countries around the world are actively implementing carbon peak and carbon neutrality goals. In-depth research on carbon peak can help improve environmental conditions and achieve a harmonious coexistence between economic development and environmental protection. However, a comprehensive review of the current status of research in this area is scarce. Therefore, this article explores the current research evolution and hotspots of "carbon peak" with the help of CiteSpace visualization software, predicts the future development trends, and builds a knowledge network framework. A comprehensive analysis of the research on carbon peak from multiple perspectives is presented. The results show that the number of papers published on carbon peak is increasing every year, and that carbon peak has become a widely participated research area. Publications from various institutions and journals have also attracted widespread attention. The research hotspots of carbon peak have constantly changed with time, resulting in many theoretical and technological innovations. The knowledge framework of the field is constructed on this basis, which gives readers a clearer understanding of the development and trends in the field and provides some reference and help for future researchers.
    Keywords:  Bibliometric analysis; Carbon peak; CiteSpace; Framework; Visualization
    DOI:  https://doi.org/10.1007/s11356-024-32008-7
  26. Front Cardiovasc Med. 2023 ;10 1332291
    Congenital heart disease research landscape in the Arab world: a 25-year bibliometric review.
    Fouad Bitar, Mariam Arabi, Ziad Bulbul, Georges Nemer, Yehya Jassar, Fadi F Bitar, Zahi Abdul Sater.
       Background: While research on congenital heart disease has been extensively conducted worldwide, comprehensive studies from developing countries and the Arab world remain scarce.
    Aim: This study aims to perform a bibliometric review of research on congenital heart disease in the Arab world from 1997 to 2022.
    Methods: We analyzed data from the Web of Science, encompassing various aspects such as topics, countries, research output, citations, authors, collaborations, and affiliations. This comprehensive science mapping analysis was done using the R statistical software's Bibliometrix Package.
    Results: The research output from Arab countries over the 25 years showed an average annual growth rate of 11.5%. However, Arab countries exhibited lower research productivity than the United States and Europe, with a 24-fold difference. There was substantial variation in research output among 22 Arab countries, with five countries contributing to 78% of the total publications. Most of the published research was clinical, with limited innovative contributions and a preference for regional journals. High-income Arab countries displayed higher research productivity and citation rates than their low-income developing counterparts. Despite being categorized as upper-middle-income, post-conflict countries exhibited low research productivity. About one-quarter of the published articles (26%) resulted from collaborative efforts among multiple countries, with the United States being the most frequent collaborator. Enhanced research productivity and impact output were strongly associated with increased international cooperation.
    Conclusion: Research productivity in the Arab region closely correlates with a country's GDP. Success hinges on governmental support, funding, international collaboration, and a clear research vision. These findings offer valuable insights for policymakers, educational institutions, and governments to strengthen research programs and nurture a research culture.
    Keywords:  Arab countries; children; congenital heart disease; developing and developed countries; limited resource countries; pediatric cardiology; research
    DOI:  https://doi.org/10.3389/fcvm.2023.1332291
  27. Am J Orthod Dentofacial Orthop. 2024 Jan 25. pii: S0889-5406(23)00650-9. [Epub ahead of print]
    Bibliometric and visualized analysis of randomized controlled trials in orthodontics between 1991 and 2022.
    Shuhua Wang, Di Fu, Ling Zou, Zhihe Zhao, Jun Liu.
       INTRODUCTION: In many evidence-based approaches to orthodontic research, randomized controlled trials (RCTs) represent authoritative evidence to identify rational therapeutics. This study aimed to perform mappings of bibliometric networks on orthodontic RCTs and summarize visual characteristics between 1991 and 2022.
    METHODS: The articles were retrieved from the Web of Science Core Collection in October 2022 without an initial time limit. Only orthodontic RCTs were eligible. Some bibliometric tools (HistCite, VOSviewer, SCImago Graphica, and CiteSpace) were applied for visualized analysis. Data such as geography, productive institutions, hot articles, journals, authors, references, and keywords were extracted and summarized for analysis.
    RESULTS: A total of 1122 orthodontic RCTs were searched. A total of 4125 authors from 1157 institutions in 65 countries published orthodontic RCTs. The United States (149) was the most prolific country, and the University of Sao Paulo (35) was the most productive institution. The American Journal of Orthodontics and Dentofacial Orthopedics (206) was the most popular journal for scholars. The visualization results of keyword co-occurrence identified 5 clusters: (1) tooth movement and auxiliary measures, (2) appliances and oral health, (3) orthodontic discomfort and symptomatic therapy, (4) periodontal disease in orthodontics and health maintenance, and (5) retention and relapse.
    CONCLUSIONS: Over the past 31 years, publications and citations on orthodontic RCTs from the Web of Science Core Collection have increased notably across many countries, authors, and institutions. Recently, there has been a significant increase in the attention to orthodontic RCTs that focus on accelerating tooth movement.
    DOI:  https://doi.org/10.1016/j.ajodo.2023.11.007
  28. Front Bioeng Biotechnol. 2023 ;11 1327027
    Global research trends and hotspots on tendon-derived stem cell: a bibliometric visualization study.
    Songou Zhang, Jinxiang Shang, Zhiqian Gu, Xiaopeng Gu, Fei Wang, Xujun Hu, Guoliang Wu, Huan Zou, Jian Ruan, Xinkun He, Chenzhou Bao, ZhenYu Zhang, Xin Li, Hong Chen.
      Purpose: This study was aimed to examine the global research status and current research hotspots in the field of tendon stem cells. Methods: Bibliometric methods were employed to retrieve relevant data from the Web of Science Core Collection (WOSCC) database. Additionally, Citespace, Vosviewer, SCImago, and Graphad Prism were utilized to analyze the publication status in this field, identify the current research hotspots, and present a mini-review. Results: The most active countries in this field were China and the United States. Notable authors contributing significantly to this research included Lui Pauline Po Yee, Tang Kanglai, Zhang Jianying, Yin Zi, and Chen Xiao, predominantly affiliated with institutions such as the Hong Kong Hospital Authority, Third Military Medical University, University of Pittsburgh, and Zhejiang University. The most commonly published journals in this field were Stem Cells International, Journal of Orthopedic Research, and Stem Cell Research and Therapy. Moreover, the current research hotspots primarily revolved around scaffolds, molecular mechanisms, and inflammation regulation. Conclusion: Tendon stem cells hold significant potential as seed cells for tendon tissue engineering and offer promising avenues for further research Scaffolds, molecular mechanisms and inflammation regulation are currently research hotspots in this field.
    Keywords:  bibliometric analysis; inflammation; mechanism; scaffolds; tendon injury; tendon-derived stem cell
    DOI:  https://doi.org/10.3389/fbioe.2023.1327027
  29. Front Plant Sci. 2023 ;14 1294989
    Worldwide productivity and research trend on fruit quality: a bibliometric study.
    Fei Ni, Ziwei Li, Jianzi Huang.
       Introduction: As one of the important sources of food for human beings, fruits have been extensively studied. To better guide basic and applied research, it is urgent to conduct a systematic analysis of these studies based on extensive literature collection.
    Methods: Based on the Web of Science Core Collection database, this study uses R language and CiteSpace to conduct bibliometric analysis and data mining on the literatures related to fruit quality from January 2013 to June 2023.
    Results: The results indicated that among various fruits, tomatoes have been most frequently studied with special interests in photosynthesis, fruit development, and molecular breeding. The research direction primarily focused on fruit resistance and storage characteristics. Among the indicators related to fruit quality, antioxidant activity has the highest co-occurrence with other indicators of fruit quality, especially with nutrients such as anthocyanins, phenolic substances, sugars, and fruit firmness.
    Discussion: Currently, adaptation to stress and antioxidant activity are recognized as prominent research focal points in this field. Fruit morphology, particularly fruit size, irrigation methods, application of molecular technology, and infection prevention, represent potential areas of interests in future research on fruit quality.
    Keywords:  antioxidant; bibliometric analysis; fruit quality; hot topic; research trend
    DOI:  https://doi.org/10.3389/fpls.2023.1294989
  30. Heliyon. 2024 Jan 15. 10(1): e24051
    Knowledge map of thrombopoietin receptor agonists: A bibliometric analysis.
    Rong Hu, Songbin Guo, Min Liu.
      Thrombopoietin receptor agonists (TPO-RAs) have been widely used to treat thrombocytopenia, however, a scientometric profile of TPO-RAs research is lacking. Methods: This study uses VOSviewer, CiteSpace, and R software to provide an overview of current research, highlight study hotspots, and predict future research directions of TPO-RAs. Results: One thousand seven hundred and nineteen relevant studies from 1993 to 2022 with 43962 citations were identified from the Web of Science Core Collection. Over three decades, the USA has been leading TPO-RAs publications. Industries and academic institutions have been actively involved in TPO-RAs research, with funding provided by pharmaceutical companies and public funding bodies. The most productive and cited journals are British Journal of Hematology and Blood, respectively. When author keywords were categorised into three clusters, i.e., cluster 1 (immune thrombocytopenic purpura (ITP)), cluster 2 (avatrombopag, lusutrombopag, and thrombocytopenia), and cluster 3 (TPO-RAs for ITP and off-label drug use), ITP was found to be the current research hotspot, while oral TPO-RAs and licensed or unlicensed drug indications of thrombocytopenic diseases require further investigation. Conclusion: This study has generated the knowledge map of TPO-RAs, which provides a dynamic roadmap for future research in this field.
    Keywords:  Bibliometrics; ITP; Off-label drug use; Thrombocytopenia; Thrombopoietin receptor agonist
    DOI:  https://doi.org/10.1016/j.heliyon.2024.e24051
  31. Musculoskelet Surg. 2024 Jan 24.
    The gender role in the publishing of Authorships in high-impact orthopedic journals.
    E Vitale, D Bizzoca, F Di Dio, A Moretti, B Moretti.
      To evidence the existence of a gender gap in the orthopedic scientific literature by including also differences between some specific orthopedic surgery specialities, such as hands and feet. Then, we also considered gender role in the Authorship linked with the economic wealth of each country belonging to each Author. The gender of the first Authors of journals on orthopedics and sports medicine indexing in the Scopus database with the highest impact factor (IF) related to the year 2019, for the period from January 1, 2015, to December 31, 2020, were considered. A total of 11 journals were considered, including a total of 5474 articles, 1087 (19.86%) had a woman as the first Author and 4387 (80.14%) a man. During the studied period, the trend seems to be the same (p = 0.906): Men were significantly more producing than women in the orthopedic field both by considering the topic of the journal (p = .003), all the most impacted orthopedic journals (p < 0.001) and economies (p < 0.001). There was therefore a strong significance: In the orthopedic field, there were significantly more male researchers who presented their first name in scientific publications compared to females in all orthopedic subspecialties. The economically poorer countries published less and the role of women became almost absent.
    Keywords:  Authorship; Female; Gender role; Male; Orthopedics trend; Publishing trends
    DOI:  https://doi.org/10.1007/s12306-023-00810-0
  32. Clin Exp Med. 2024 Jan 22. 24(1): 14
    Global landscape of COVID-19 research: a visualization analysis of randomized clinical trials.
    Sa'ed H Zyoud.
      The emergence of COVID-19 in 2019 has resulted in a significant global health crisis. Consequently, extensive research was published to understand and mitigate the disease. In particular, randomized controlled trials (RCTs) have been considered the benchmark for assessing the efficacy and safety of interventions. Hence, the present study strives to present a comprehensive overview of the global research landscape pertaining to RCTs and COVID-19. A bibliometric analysis was performed using the Scopus database. The search parameters included articles published from 2020 to 2022 using keywords specifically related to COVID-19 and RCTs. The data were analyzed using various bibliometric indicators. The volume of publications, contributions of countries and institutions, funding agencies, active journals, citation analysis, co-occurrence analysis, and future research direction analysis were specifically analyzed. A total of 223,480 research articles concerning COVID-19 were published, with 3,727 of them related to RCTs and COVID-19. The ten most productive countries collectively produced 75.8% of the documents, with the United States leading the way by contributing 31.77%, followed by the UK with 14.03% (n = 523), China with 12.96% (n = 483) and Canada with 7.16% (n = 267). Trials (n = 173, 4.64%), BMJ Open (n = 81, 2.17%), PLOS One (n = 73, 1.96%) and JAMA Network Open (n = 53, 1.42%) were the most active journals in publishing articles related to COVID-19 RCTs. The co-occurrence analysis identified four clusters of research areas: the safety and effectiveness of COVID-19 vaccines, mental health strategies to cope with the impact of the pandemic, the use of monoclonal antibodies to treat patients with COVID-19, and systematic reviews and meta-analyses of COVID-19 research. This paper offers a detailed examination of the global research environment pertaining to RCTs and their use in the context of the COVID-19 pandemic. The comprehensive body of research findings was found to have been generated by the collaborative efforts of multiple countries, institutions, and funding organizations. The predominant research areas encompassed COVID-19 vaccines, strategies for mental health, monoclonal antibodies, and systematic reviews. This information has the potential to aid researchers, policymakers, and funders in discerning areas of weakness and establishing areas of priority.
    Keywords:  Bibliometric; COVID-19; Randomized controlled trials; Scopus; VOSviewer; Visualization
    DOI:  https://doi.org/10.1007/s10238-023-01254-3
  33. J Curr Ophthalmol. 2023 Apr-Jun;35(2):35(2): 145-152
    Scientific Publications and Subject Clusters in the Field of Glaucoma: A Scientometric Analysis.
    Azadeh Haseli-Mofrad, Arefeh Kalavani, Maryam Shekofteh, Zhale Rajavi, Hamideh Sabbaghi, Sare Safi, Hamed Esfandiari.
       Purpose: To analyze the glaucoma research in the Web of Science (WoS) and Scopus to determine the top features, trends, and subject clusters.
    Methods: In this scientometric study, all glaucoma publications in Scopus and WoS were analyzed based on various characteristics such as authors, journals, and co-word analysis. Data analysis was conducted using both Excel and VOSviewer.
    Results: A gradual increase in the publication rate was found for articles in the field of glaucoma in both Scopus and WoS databases. In this regard, most publications were conducted in the USA and the University of California System. The co-word network was constituted of five clusters, including glaucoma, intraocular pressure, open-angle glaucoma, visual acuity, and optic disc. It showed that the top 10 highly cited articles were more addressed by epidemiologic studies.
    Conclusions: The findings of this study had a more precise vision of the previous research on the field of glaucoma. It also provided the possibility to discover hidden patterns and emerging events of a subject by explaining the most essential aspects of research and identifying the areas that need more research. The findings could be useful for authors and health policymakers in academia and countries.
    Keywords:  Glaucoma; Intraocular pressure; Scientific publications; Scientometrics; Scopus; Web of Science
    DOI:  https://doi.org/10.4103/joco.joco_78_23
  34. Front Pharmacol. 2023 ;14 1322319
    A bibliometric and visual analysis of the use of ustekinumab in Crohn's disease using CiteSpace.
    Yi Chen, Jiaqi Zhang, Junling Wu, Hanwen Zhang, Zhe Luan, Zhizhuang Zhao, Congyong Li, Yiming Zhao, Hu Zhang, Shufang Wang, Gang Sun.
      Background: The novel biologic agent ustekinumab (UST), a monoclonal antibody against the p40 subunit of interleukin-12 and interleukin-23, has been applied in the treatment of Crohn's disease (CD). With the development of relevant research, the clinical treatment and favorable prognosis of UST in CD have garnered considerable attention. However, there is a lack of reports that present the current status of UST-related studies in a comprehensive and objective manner. Consequently, this study aims to visually analyze the current status and clinical trends of UST-related research, identify leading researchers, and recognize deficiencies using bibliometrics and knowledge mapping, which might assist in understanding future research priorities in that specific field. Methods: Published articles containing the use of UST in CD were retrieved from the Web of Science core collection database between 2008 and 2022. Then, the bibliometric analysis was performed, and a knowledge map was generated and visualized using the CiteSpace software. Results: A total of 479 articles published between 2008 and 2022 were included in the bibliometric analysis. These publications were authored by 185 scholars from 51 countries or regions, among which the United States (38.3%), Canada (16.9%) and England (10.0%) were predominant in publishing. The keyword analysis indicated that UST has long been a popular biologic agent, and its clinical efficacy, safety, and indication for vulnerable populations in CD are popular research topics. The phrase "fecal calprotectin," a biomarker reflecting the degree of disease activity and monitoring the therapeutic response, began to gain traction in 2020 and has continued to this day. Looking for UST-related biomarkers was gaining clinical attention. Conclusion: The number of clinical studies involving the outcome of UST treatment in CD patients has increased, with the current research focusing on efficacy, safety, indications for vulnerable populations, therapeutic drug monitoring, and biomarkers. As an alternative drug after the failure of traditional immunosuppressive therapies or TNF-α antagonist therapy, UST is an effective and safe therapy in real-world refractory CD patients. UST will remain an active candidate for research in the treatment of CD.
    Keywords:  Crohn’s disease; bibliometric analysis; biomarker; safety; ustekinumab
    DOI:  https://doi.org/10.3389/fphar.2023.1322319
  35. Cannabis Cannabinoid Res. 2024 Jan 19.
    Bibliometric Analysis of Cannabis sativa Research: Trends, Challenges, and Future Directions.
    Brayan Jonas Mano-Sousa, Lucas Antônio Ribeiro Lisboa, Bruna Cristina Alves, Ana Clara Anacleto Gonçalves, Luiza Martins Silva, Joaquim Maurício Duarte-Almeida.
      Introduction: The use of medical Cannabis remains unregulated in several countries due to the scarcity of clinical studies with high scientific evidence that establish safety and efficacy of Cannabis products. This study aimed to comprehensively analyze how knowledge has been created in this field, as well as perform a bibliographic mapping to identify knowledge gaps, and investigate key authors and journals that have significantly contributed to advancing our understanding of Cannabis. Method: The study protocol was registered in the International Prospective Register of Systematic Review (CRD42020223084). A systematic search was conducted in the Cochrane Central Register of Controlled Trials, Lilacs, Google Scholar, PubMed, SciELO, Scopus, and Web of Science databases. The bibliographic analysis and mapping were registered using the VOSviewer, Sci2tool, CiteSpace, and PoP software. Results: The systematic search identified 27,597 records, with 17,020 duplicates, resulting in a total of 10,577 articles included. The authors who published the most were Marilyn Ann Huestis (n=108) and Sagnik Bhattacharyya (n=71), while Elisaldo A. Carlini and Raphael Mechoulam published 8 and 22 articles, respectively. The journals Drug and Alcohol Dependence (n=297), Psychopharmacology (n=159) and Addictive Behaviors (n=150) were the ones that published the most on Cannabis. The journals suggest that the articles are correlated with the adverse and toxicological effects of recreational Cannabis use; however, most articles focus on medical Cannabis. The peak of publications was in 2021 (n=1,481). The countries that published the most were the United States (n=9,735), while Brazil occupied the 11th position (n=422). Most publications were carried out in "Pharmacology and Pharmacy" (11.31%), followed by "Psychiatry" (7.66%) and "Medicine" (5.80%). The areas of "Neurosciences" (1.59%), "Biochemistry," "Genetics," and "Molecular Biology" (0.79%) were little explored. Conclusion: This study captured the characteristics of publications about Cannabis and clinical studies in the scientific literature, yielding >10,000 articles, representing a large literature review, to date. Therefore, the most productive countries included the United States, the United Kingdom, and Canada, while the most productive authors were Marilyn Ann Huestis and Sagnik Bhattacharyya, with a peak of publications in 2021. Finally, the most chosen journals were Drug and Alcohol Dependence and Psychopharmacology.
    Keywords:  Cannabis; Scientometrics; bibliometric analysis; research trends; systematic review
    DOI:  https://doi.org/10.1089/can.2023.0200
  36. Front Oncol. 2023 ;13 1296511
    Bibliometric and visual analysis in the field of tea in cancer from 2013 to 2023.
    Yuanchu Lian, Xiating Li, Ying Lan, Zonghuai Li, Xiaoxin Lin, Jing'an Huang, Bo Zhang, Zhongwen Feng.
       Objective: Tea has been utilized in cancer research and is progressively gaining wider recognition, with its roles in cancer prevention and treatment being increasingly affirmed. The objective of this study is to investigate the current state and research hotspots in the field of tea's involvement in cancer research from 2013 to 2023, aiming to offer reference and direction for future studies.
    Methods: We analyzed 4,789 articles published between 2013 and 2022 from the Web of Science database using VOSviewer, R software, and CiteSpace software.
    Result: Tea-related cancer research showed an overall upward trend, with China leading in publications, followed by the United States, India, Japan, and Italy. China also had significant international collaborations, notably with Harvard University and the Egyptian Knowledge Bank. The 'Journal of Agricultural and Food Chemistry' was the most cited journal. Key topics included 'green tea,' 'cancer,' 'in vitro,' 'oxidative stress,' and 'apoptosis.' Research focused on tea's pharmacological effects, anticancer properties, mechanisms of natural compounds (e.g., polyphenols and EGCG), antioxidant and antimicrobial properties, and molecular mechanisms in cancer treatment.
    Conclusion: Tea's potential as an anti-cancer medication is gaining global recognition. Our study provides a comprehensive analysis of tea-related cancer research from 2013 to 2023, guiding future investigations in this field.
    Keywords:  bibliometric; cancer; molecular mechanisms; polyphenols; tea
    DOI:  https://doi.org/10.3389/fonc.2023.1296511
  37. Health Econ Rev. 2024 Jan 25. 14(1): 6
    Research trends in contemporary health economics: a scientometric analysis on collective content of specialty journals.
    Clara C Zwack, Milad Haghani, Esther W de Bekker-Grob.
       INTRODUCTION: Health economics is a thriving sub-discipline of economics. Applied health economics research is considered essential in the health care sector and is used extensively by public policy makers. For scholars, it is important to understand the history and status of health economics-when it emerged, the rate of research output, trending topics, and its temporal evolution-to ensure clarity and direction when formulating research questions.
    METHODS: Nearly 13,000 articles were analysed, which were found in the collective publications of the ten most specialised health economic journals. We explored this literature using patterns of term co-occurrence and document co-citation.
    RESULTS: The research output in this field is growing exponentially. Five main research divisions were identified: (i) macroeconomic evaluation, (ii) microeconomic evaluation, (iii) measurement and valuation of outcomes, (iv) monitoring mechanisms (evaluation), and (v) guidance and appraisal. Document co-citation analysis revealed eighteen major research streams and identified variation in the magnitude of activities in each of the streams. A recent emergence of research activities in health economics was seen in the Medicaid Expansion stream. Established research streams that continue to show high levels of activity include Child Health, Health-related Quality of Life (HRQoL) and Cost-effectiveness. Conversely, Patient Preference, Health Care Expenditure and Economic Evaluation are now past their peak of activity in specialised health economic journals. Analysis also identified several streams that emerged in the past but are no longer active.
    CONCLUSIONS: Health economics is a growing field, yet there is minimal evidence of creation of new research trends. Over the past 10 years, the average rate of annual increase in internationally collaborated publications is almost double that of domestic collaborations (8.4% vs 4.9%), but most of the top scholarly collaborations remain between six countries only.
    Keywords:  Cost-effectiveness; Health economics; Macroeconomics; Microeconomics; Scientometric analysis
    DOI:  https://doi.org/10.1186/s13561-023-00471-6
  38. Healthcare (Basel). 2024 Jan 13. pii: 197. [Epub ahead of print]12(2):
    Effects of Physical Activity on Body Composition, Muscle Strength, and Physical Function in Old Age: Bibliometric and Meta-Analyses.
    Yerim Choi, Daekyoo Kim, Seung Kyum Kim.
       OBJECTIVES: Accumulating evidence suggests that physical activity (PA) is an efficient intervention to maintain functional capabilities and mitigate physiological changes in the older population. However, an attempt has yet to be made to comprehensively investigate the published landscape on the subject.
    METHODS: This study had two aims. The first aim was to perform a bibliometric analysis for two keywords, "aging" and "PA", to analyze the research trend. Since "frailty" was the most noticeable co-occurring keyword with the two keywords, the second aim was to investigate the effects of PA, particularly, resistance training (RT), on frailty using a meta-analysis to provide a summary of the current evidence base.
    RESULTS: The bibliometric analysis revealed that the number of publications on this research topic has gradually increased, highlighting the importance of understanding the role of PA in aging. The meta-analysis found that RT had significant beneficial effects on physical frailty factors, including handgrip strength, lower limb strength, balance, gait speed, and stair-climbing ability.
    CONCLUSION: These findings demonstrate that RT is an effective intervention for improving physical function in frail populations; thus, it has important implications for the development of PA programs for older adults with frailty. Future research is warranted to explore the optimal dose, frequency, and duration of RT programs for older adults, as well as the potential benefits of combining RT with other forms of PA, such as aerobic or balance exercises.
    Keywords:  aging; bibliometric analysis; frailty; meta-analysis; physical activity; resistance training
    DOI:  https://doi.org/10.3390/healthcare12020197
  39. Med Educ Online. 2024 Dec 31. 29(1): 2308359
    Medical education research study quality instrument: an objective instrument susceptible to subjectivity.
    Scott Jaros, Gary Beck Dallaghan.
       BACKGROUND: The medical education research study quality instrument (MERSQI) was designed to appraise medical education research quality based on study design criteria. As with many such tools, application of the results may have unintended consequences. This study applied the MERSQI to published medical education research identified in a bibliometric analysis.
    METHODS: A bibliometric analysis identified highly cited articles in medical education that two authors independently evaluated using the MERSQI. After screening duplicate or non-research articles, the authors reviewed 21 articles with the quality instrument. Initially, five articles were reviewed independently and results were compared to ensure agreed upon understanding of the instrument items. The remainder of the articles were independently reviewed. Overall scores for the articles were analyzed with a paired samples t-test and individual item ratings were analyzed for inter-rater reliability.
    RESULTS: There was a significant difference in mean MERSQI score between reviewers. Inter-rater reliability for MERSQI items labeled response rate, validity and outcomes were considered unacceptable.
    CONCLUSIONS: Based on these results there is evidence that MERSQI items can be significantly influenced by interpretation, which lead to a difference in scoring. The MERSQI is a useful guide for identifying research methodologies. However, it should not be used to make judgments on the overall quality of medical education research methodology in its current format. The authors make specific recommendations for how the instrument could be revised for greater clarity and accuracy.
    Keywords:  MERSQI; Medical education; bibliometric analysis; quality; research
    DOI:  https://doi.org/10.1080/10872981.2024.2308359
  40. Foods. 2024 Jan 13. pii: 257. [Epub ahead of print]13(2):
    Food Retail Resilience Pre-, during, and Post-COVID-19: A Bibliometric Analysis and Research Agenda.
    Rebeka-Anna Pop, Dan-Cristian Dabija, Cristina Bianca Pocol.
      This paper aims to conduct a bibliometric mapping and systematic review of the food retail industry's resilience strategy in the context of COVID-19. Specifically, we aim to identify relevant research gaps in the industry during the pre-, during, and post-pandemic periods and highlight the differences between B2B and B2C sectors. We analyzed articles in the Scopus database from 2019 to 2022 using the PRISMA method for article selection, resulting in a total of 69 articles. We employed a VOS viewer for bibliometric mapping. Our analysis revealed that most studies focused on the impact of COVID-19, with only a few examining the pre- and post-pandemic periods critically. In the B2C context, we identified two major topics: changes in purchasing and consumption behavior, and food waste and safety. In the B2B sector, the two most recurrent subjects were retailers' strategies and supply chain management. This study provides valuable insights for policymakers by exploring industry trends and for scholars by highlighting future research agendas based on the identified topics.
    Keywords:  B2B; B2C; COVID-19; bibliometric analysis; food retail; resilience; strategy
    DOI:  https://doi.org/10.3390/foods13020257
  41. Nanomaterials (Basel). 2024 Jan 13. pii: 186. [Epub ahead of print]14(2):
    Graphene Oxide (GO) for the Treatment of Bone Cancer: A Systematic Review and Bibliometric Analysis.
    Lemy Vanessa Barba-Rosado, Domingo César Carrascal-Hernández, Daniel Insuasty, Carlos David Grande-Tovar.
      Cancer is a severe disease that, in 2022, caused more than 9.89 million deaths worldwide. One worrisome type of cancer is bone cancer, such as osteosarcoma and Ewing tumors, which occur more frequently in infants. This study shows an active interest in the use of graphene oxide and its derivatives in therapy against bone cancer. We present a systematic review analyzing the current state of the art related to the use of GO in treating osteosarcoma, through evaluating the existing literature. In this sense, studies focused on GO-based nanomaterials for potential applications against osteosarcoma were reviewed, which has revealed that there is an excellent trend toward the use of GO-based nanomaterials, based on their thermal and anti-cancer activities, for the treatment of osteosarcoma through various therapeutic approaches. However, more research is needed to develop highly efficient localized therapies. It is suggested, therefore, that photodynamic therapy, photothermal therapy, and the use of nanocarriers should be considered as non-invasive, more specific, and efficient alternatives in the treatment of osteosarcoma. These options present promising approaches to enhance the effectiveness of therapy while also seeking to reduce side effects and minimize the damage to surrounding healthy tissues. The bibliometric analysis of photothermal and photochemical treatments of graphene oxide and reduced graphene oxide from January 2004 to December 2022 extracted 948 documents with its search strategy, mainly related to research papers, review papers, and conference papers, demonstrating a high-impact field supported by the need for more selective and efficient bone cancer therapies. The central countries leading the research are the United States, Iran, Italy, Germany, China, South Korea, and Australia, with strong collaborations worldwide. At the same time, the most-cited papers were published in journals with impact factors of more than 6.0 (2021), with more than 290 citations. Additionally, the journals that published the most on the topic are high impact factor journals, according to the analysis performed, demonstrating the high impact of the research field.
    Keywords:  bibliometric analysis; bone cancer; graphene oxide; osteosarcoma; reduced graphene oxide
    DOI:  https://doi.org/10.3390/nano14020186
  42. Mini Rev Med Chem. 2024 Jan 12.
    Artificial Intelligence in Drug Discovery: A Bibliometric Analysis and Literature Review.
    Baoyu He, Jingjing Guo, Henry H Y Tong, Wai Ming To.
      Drug discovery is a complex and iterative process, making it ideal for using artificial intelligence (AI). This paper uses a bibliometric approach to reveal AI's trend and underlying structure in drug discovery (AIDD). A total of 4310 journal articles and reviews indexed in Scopus were analyzed, revealing that AIDD has been rapidly growing over the past two decades, with a significant increase after 2017. The United States, China, and the United Kingdom were the leading countries in research output, with academic institutions, particularly the Chinese Academy of Sciences and the University of Cambridge, being the most productive. In addition, industrial companies, including both pharmaceutical and high-tech ones, also made significant contributions. Additionally, this paper thoroughly discussed the evolution and research frontiers of AIDD, which were uncovered through co-occurrence analyses of keywords using VOSviewer. Our findings highlight that AIDD is an interdisciplinary and promising research field that has the potential to revolutionize drug discovery. The comprehensive overview provided here will be of significant interest to researchers, practitioners, and policy-makers in related fields. The results emphasize the need for continued investment and collaboration in AIDD to accelerate drug discovery, reduce costs, and improve patient outcomes.
    Keywords:  AI; Scopus; VOSviewer; artificial intelligence; bibliometric; drug discovery
    DOI:  https://doi.org/10.2174/0113895575271267231123160503
  43. Transplant Proc. 2024 Jan 23. pii: S0041-1345(23)00763-7. [Epub ahead of print]
    Sex Disparities in Academic Productivity and Rank Among Abdominal Transplant Faculty in the United States.
    Damilola R Fakunle, Allison M Ammann, Stephanie Sisak, Aaron M Delman, Dennis M Vaysburg, Kristina Lemon, Latifa Silski, Tammy Holm, Shimul A Shah, Ralph C Quillin.
       BACKGROUND: The aim of this study was to examine sex differences in academic rank and productivity among members of the American Society of Transplant Surgeons in the United States.
    METHODS: Cross-sectional, focusing on current board-certified abdominal transplant surgeons in the United States. Demographic factors such as sex, region, and faculty rank were collected from institutional websites. Academic metrics, including H-index, total publications, and relative citation ratio, were collected from Scopus and iCite.
    RESULTS: We identified 536 surgeon members of the American Society of Transplant Surgeons with an academic institution. The majority were men (83%). Men were in practice longer than women (17.9 ± 11 vs 11.7 ± 9 years, P < .0001) and had higher academic metrics, including H-index (25.6 ± 20 vs16.4 ± 14, P < .0001) and total publications (110 ± 145 vs 58.8 ± 69, P < .0001). There was a significant difference in faculty appointments by sex (P < .05), with men showing evidence of increased academic advancement. After adjusting for academic rank, PhD status, and location of medical school and residency, women remained associated with a lower H-index on multivariate analysis (P < .01).
    CONCLUSION: Sex disparities in academic rank and achievement are present among transplant surgical faculty in the United States, and future efforts are needed to promote sex equity in transplant surgery academia.
    DOI:  https://doi.org/10.1016/j.transproceed.2023.11.008
  44. Heliyon. 2024 Jan 30. 10(2): e24395
    Global trends in bufalin application research for cancer from 2003 to 2022: A bibliometric and visualised analysis.
    Donghao Tang, Yuejiao Feng, Jiahao Lu, Linlin Jia, Dongxiao Shen, Jing Shang, Teng Chen, Peihao Yin, Jinbao Chen, Jie Wang.
       Background: Bufalin, the main active ingredient of the traditional Chinese medicine huachansu, is used in the clinical treatment of colorectal cancer and has multiple effects, including the inhibition of migratory invasion, reversal of multi-drug resistance, induction of apoptosis and differentiation, and inhibition of angiogenesis.
    Methods: We collected relevant articles on bufalin from 2003 to 2022 using the Web Science platform, and analysed the information using VOSviewer, CiteSpace, and Microsoft Excel to categorise and summarise the publications over the past 20 years.
    Results: We collected 371 papers, with a steady increase in the number of articles published globally. China has the highest number of published articles, whereas Japan has the highest number of citations. Currently, there is considerable enthusiasm for investigating the anti-tumour mechanism of bufalin and optimising drug delivery systems for its administration.
    Conclusion: For the first time, we present a comprehensive overview of papers published worldwide on bufalin over the past two decades and the progress of its application in tumour therapy. We summarised the key authors, institutions, and countries that have contributed to the field and the potential of bufalin for the treatment of cancer. This will help other researchers obtain an overview of progress in the field, enhance collaboration and knowledge sharing, and promote future research on bufalin.
    Keywords:  Bibliometric approach; Bufalin; Cancer
    DOI:  https://doi.org/10.1016/j.heliyon.2024.e24395
  45. Stud Health Technol Inform. 2024 Jan 25. 310 289-293
    Analyzing the Spread of Informatics with PubMed.
    Brian E Chapman, Wendy W Chapman, Jeremiah Chapman.
      We analyzed PubMed citations since 1988 to explore the dissemination of medical/health informatics concepts between countries and across medical domains. We extracted countries from the PubMed author affiliation field to identify and analyze the top 10 informatics publishing countries. We found that the informatics publications are becoming more similar over time and that the rate of exchange across countries has increased with the introduction of e-publishing. Nonetheless, with the exception of machine learning, the impact of core informatics concepts on mainstream medicine and radiology publications remains small.
    Keywords:  MeSH; bibliometrics; medical informatics
    DOI:  https://doi.org/10.3233/SHTI230973
  46. Br J Gen Pract. 2024 Feb;74(739): e120-e125
    General practice-related MeSH terms in main journals: a bibliometric analysis from 2011 to 2021.
    Théo Duguet, Gladys Ibanez, Matthieu Schuers, Jean-Pierre Lebeau, Kristell Roser, Cécilia Saldanha Gomes, Jean-Sébastien Cadwallader.
       BACKGROUND: There are various Medical Subject Headings (MeSH) terms used to index general practice research, without consistency.
    AIM: To understand how general practice-related research is indexed in the main general practice journals between 2011 and 2021, and to analyse the factors that influenced the choice of the general practice-related MeSH.
    DESIGN AND SETTING: This was a quantitative bibliometric study conducted on MEDLINE.
    METHOD: MeSH were selected according to the international definition of General Practice/Family Medicine: 'General Practice', 'Primary Health Care', 'Family Practice', 'General Practitioners', 'Physicians, Primary Care', and 'Physicians, Family'. Their use was studied from 2011 to 2021 on MEDLINE, reviewing the 20 general practice journals with the highest impact factors. A descriptive and analytical approach was used; the association of the country, journal, and year with the choice of general practice-related MeSH terms was analysed.
    RESULTS: A total of 8514 of 150 286 articles (5.7%) were using one of the general practice-related MeSH terms. The most used were 'Primary Health Care' (4648/9984, 46.6%) and 'General Practice' (2841/9984, 28.5%). A total of 80.0% (6172/7723) of the articles were related to the UK or US and 71.0% (6055/8514) of the articles came from four journals (BJGP, BMJ, Journal of General Internal Medicine, and Annals of Family Medicine). Two main country clusters emerged from the use of general practice-related MeSH: a British cluster mainly using 'General Practice' and an American cluster using 'Primary Health Care'. The journals also mainly differed in their used of these two MeSH terms.
    CONCLUSION: Important variations in the indexation of general practice research were found. Researchers should consider combining 'Primary Health Care' and 'General Practice' in their PubMed searches to access all the general practice research, regardless of their country of origin.
    Keywords:  bibliometrics; family physicians, primary care; family practice; general practice; general practitioners; physicians, primary health care
    DOI:  https://doi.org/10.3399/BJGP.2023.0060
  47. Nuklearmedizin. 2024 Jan 23.
    Global Research Output of Lutetium-177 PSMA in Prostate Cancer: Bibliometric and Altmetric Analyses.
    Rakan Al-Rashdan, Haneen Al-Abdallat, Mike Machaba Sathekge, Siroos Mirzaei, Mohammed Shahait, Khaled Al-Khawaldeh, Ahmed Saad Abdlkadir, Szeting Lee, Akram Al-Ibraheem.
       AIM: The integration of innovative radio-pharmaceutical agents targeting prostate-specific membrane antigen (PSMA) within nuclear medicine has transformed prostate cancer detection and management. This study aims to investigate the present landscape of [177Lu]Lu-PSMA in prostate cancer, elucidating trends, global contributions, scholarly outlets, institutions, and thematic concentrations with an aim to inform forthcoming research endeavors.
    METHODS: We systematically probed the Scopus repository for relevant [177Lu]Lu-PSMA literature. An assessment of bibliometric and altmetric data was carried out. Finally, we assessed the correlation between the altmetric attention scores and the number of citations for the retrieved data.
    RESULTS: Spanning January 2015 to July 2023, the study encompassed 466 articles concerning [177Lu]Lu-PSMA therapy for prostate cancer. Predominant citation accolades gravitated towards metastatic castration-resistant prostate cancer investigations and assessments of [177Lu]Lu-PSMA therapy's safety and efficacy. Further research encompassed adverse effects linked to [177Lu]Lu-PSMA intervention, including xerostomia, thrombocytopenia, anemia, and fatigue. Germany emerged as the primary academic contributor, with The Journal of Nuclear Medicine dominating publications (n = 55). A moderate significant correlation was detected between the number of citations and altmetric attention scores .
    CONCLUSION: The findings highlight the growing interest and advancements in the utilization of [177Lu]Lu-PSMA therapy in prostate cancer and offer a comprehensive global perspective on future research directions.
    DOI:  https://doi.org/10.1055/a-2221-3036
  48. Surg Radiol Anat. 2024 Jan 25.
    Research trends on maxillary sinus septa in 2019-2021: a scoping review with scientometric analysis.
    Irika Miyao, Shigeo Osato, Yukari Nakajima, Tadakazu Miyao.
       PURPOSE: This study aimed to conduct a bibliometric analysis of trends in the description items within the literature published from 2019 to 2021 with "maxillary sinus septum" in the title or subtitle.
    METHODS: Electronic data from PubMed (MEDLINE), Google Scholar, and ScienceDirect were searched from 2019 to 2021. We used the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) to select 21 of 243 articles and examined their studies. Statistical calculations from data recorded by the authors were performed using the Chi-square, Mann-Whitney, and independent tests. Significance was set at P < 0.05.
    RESULTS: The number of articles decreased annually. The highest number of publications was from Asia (64.3%), accounting for 71.4% of publications. The features of the septum were described for eight items, with one septum (70.14%) mentioned significantly more frequently, followed by on one side (65.89%) or the right side (62.22%). Location was mentioned significantly more frequently in the middle (55.22%) and for those aged 45 years and older (50.38%). No significant differences were observed in prevalence, age, height, or width between sexes; the patients' ages ranged from 18 to 90 years. Septa were significantly more prevalent in dentulous (45.38%) and partially edentulous (48.58%) patients, with significantly more patients exhibiting buccopalatal orientation (82.39%).
    CONCLUSIONS: This study focused primarily on anatomical features using CBCT examination, and analyses of male-female differences and the origin of the sinus septum are necessary for the future.
    Keywords:  Location; Maxillary sinus septum; Orientation; Origin; Prevalence
    DOI:  https://doi.org/10.1007/s00276-023-03272-y
  49. Front Oncol. 2023 ;13 1290588
    Quantitative analysis and visualization of literature on acupuncture and related TCM therapies for the treatment of colorectal cancer based on CiteSpace.
    Zeli Li, Qianwen Xiong, Shuwen Li, Wenxiang Chen, Nenggui Xu, Fanghua Qiu.
       Objective: We analyzed the literature describing the results of treatment of colorectal cancer (CRC) using acupuncture in the past three decades from the Web of Science (WoS) and Chinese databases (including CNKI, WANGFANG and VIP), and summarized the current development of CRC treatment as well as future research directions through the presentation of maps and visualization analysis.
    Methods: We searched the WoS and Chinese databases. Relevant articles were exported, and the data were organized using Excel software and was visualized and analyzed using CiteSpace software.
    Results: A total of 355 articles from the WoS and 95 articles from Chinese databases were selected for inclusion in the analysis. The articles in WoS were sourced from 174 journals, 1274 institutions, and 66 countries, and covered 299 keywords. The articles in the Chinese databases were sourced from 43 journals, 111 institutions, and 3 countries, and included 126 keywords. The article with the most citations in the WoS was cited 128 times and in the Chinese databases, the article with the most citations was cited 120 times. Acupuncture, CRC, rectal cancer, apoptosis, warm acupuncture, traditional Chinese medicine (TCM) and gastrointestinal function were mentioned most frequently in the WoS. CRC, electroacupuncture, gastrointestinal function, rectal cancer, acupuncture and moxibustion, acupuncture, and colon cancer were mentioned most frequently in the Chinese databases.
    Conclusion: Both the WoS and Chinese databases showed a gradual increase in the number of articles related to acupuncture treatment for CRC, indicating a growing interest in this area. Acupuncture treatments are diverse, including warm acupuncture, auricular acupuncture, acupuncture injection, and electroacupuncture. They are often used in combination with drugs to treat symptoms such as depression, nausea and vomiting, pain, diarrhea, and urinary and fecal incontinence, which are commonly associated with CRC.
    Keywords:  Citespace; acupuncture; colorectal cancer; literature measurement; visualization analysis
    DOI:  https://doi.org/10.3389/fonc.2023.1290588
  50. Antibiotics (Basel). 2024 Jan 08. pii: 60. [Epub ahead of print]13(1):
    An Emerging Foodborne Pathogen Spotlight: A Bibliometric Analysis and Scholarly Review of Escherichia coli O157 Research.
    Himanshu Jangid, Deepak Kumar, Gaurav Kumar, Raj Kumar, Narsimha Mamidi.
      Foodborne infections pose a substantial global threat, causing an estimated 600 million illnesses and resulting in approximately 420,000 deaths annually. Among the diverse array of pathogens implicated in these infections, Escherichia coli (E. coli), specifically the O157 strain (E. coli O157), emerges as a prominent pathogen associated with severe outbreaks. This study employs a comprehensive bibliometric analysis and scholarly review focused on E. coli O157 research. The bibliometric analysis highlights the significant role played by the United States in the E. coli O157 research domain. Further exploration underscores the noteworthy contributions of the researcher Doyle MP, whose body of work, consisting of 84 documents and an impressive H-Index of 49, reflects their substantial impact in the field. Recent research trends indicate a discernible shift towards innovative detection methods, exemplified by the adoption of CRISPR-CAS and Loop-Mediated Isothermal Amplification. Moreover, high-throughput whole-genome sequencing techniques are gaining prominence for the expeditious analysis of pathogenic E. coli strains. Scientists are increasingly exploring antimicrobial agents, including phage therapy, to address the challenges posed by antibiotic-resistant E. coli strains, thereby addressing critical concerns related to multi-drug resistance. This comprehensive analysis provides vital insights into the dynamic landscape of E. coli O157 research. It serves as a valuable resource for researchers, policymakers, and healthcare professionals dedicated to mitigating E. coli O157 outbreaks and advancing global public health strategies.
    Keywords:  Escherichia coli O157; bibliometric analysis; emerging pathogens; food safety; foodborne pathogens
    DOI:  https://doi.org/10.3390/antibiotics13010060
  51. Adv Radiat Oncol. 2024 Jan;9(1): 101323
    Assessment of Medical Student Research Mentorship in Radiation Oncology.
    Kristy Bono, Marisa Palmeri, Austin Huang, Jillian R Gunther, Malcolm D Mattes.
       Purpose: Mentored medical student (MS) research opportunities in radiation oncology (RO) provide in-depth exposure to the specialty and may promote greater interest in a career in RO. Many radiation oncologists conduct research; however, the extent to which they directly engage MSs in their research is unknown. The purpose of this study was to characterize MS authorship in American Society for Radiation Oncology (ASTRO) journals.
    Methods and Materials: The byline and abstract of all scientific articles (ie, clinical, basic science, training/education) and case reports published from 2019 to 2021 in the International Journal of Radiation Oncology, Biology, and Physics; Practical Radiation Oncology; and Advances in Radiation Oncology were reviewed. Characteristics of MSs and senior authors are reported.
    Results: A total of 105 of 1785 articles (5.8%) included an MS author, among which 72 (68.6%) were clinical, 13 training/education (12.4%), 12 case reports (11.4%), and 8 basic science (7.6%). MS authors were more common for publications in Advances in Radiation Oncology (9.0%) than Practical Radiation Oncology (6.4%) or the International Journal of Radiation Oncology, Biology, and Physics (4.2%; P = .002). There were 125 unique MS authors from 72 institutions, among which 40 were first author (32.0%), 28 second author (22.4%), and 57 third (or higher) author (45.6%). There were 88 unique senior authors from 55 institutions, among which 10 (11.3%) were on 2 or more MS publications, and 57 (64.7%) shared the same institution as the MS. The median number of articles per mentor institution was 1 (interquartile range, 1-2), and the mentor institutions in the upper quartile in terms of number of MS publications accounted for 53 (50.5%) of all MS publications.
    Conclusions: Few publications in American Society for Radiation Oncology journals include MS authors with mentorship disproportionately from a small number of academic faculty at select institutions. These findings suggest that there is great potential for radiation oncologists to proactively engage more students in their work.
    DOI:  https://doi.org/10.1016/j.adro.2023.101323
  52. Tissue Eng Part C Methods. 2024 Jan 24.
    Trends and Future Research in Skeletal Muscle Tissue Engineering in the Past Decade (2012-2022).
    Yichun Dou, Ling Zhang, Jiaqi Wang, Yun Xue, You Zhou, Yajun Liu, Liqun Zhang, Rui Shi.
      To learn about advances in skeletal muscle tissue engineering (SMTE) in recent years, we used VOSviewer and Citespace software to quantitatively analyze and visualize relevant literature in the Web of Science (WoS) database during the period 2012-2022. By mapping high-frequency keyword relationship networks, keyword time zones, and journal article co-citations, we clarified the areas of great interest, evolutionary paths, and developmental trends in research on SMTE. We conducted an in-depth analysis of highly cited and representative articles at various stages to summarize the mainstream research areas of great interest in SMTE and discussed the future development and challenges in this field, intending to provide a reference for the clinical treatment of skeletal muscle injury repair. We found that a collaborative network of authors has formed in this field; the journals publishing SMTE articles belong to the fields of biomaterials and tissue engineering, and open-access journals have played a key role in the promotion of the development of SMTE，and in the past decade, there has been rapid progress in SMTE research in terms of both depth and breadth.
    DOI:  https://doi.org/10.1089/ten.TEC.2023.0216
  53. J Glob Health. 2024 Jan 26. 14 04011
    Gender mainstreaming at 25 years: Toward an inclusive, collaborative, and structured research agenda.
    Kelsi Caywood, Gary L Darmstadt.
       Background: Gender mainstreaming has been central to the development agenda for advancing gender equality globally for nearly three decades. We examined key learning across gender mainstreaming models and experiences and assess key successes and challenges in actualising gender mainstreaming's transformative potential, in order to inform future research agendas.
    Methods: We reviewed 27 years of peer-reviewed literature on gender mainstreaming (1995-2022) and described scholarly publishing trends on the topic based on a set of 528 articles and bibliographic data retrieved from the Scopus database and supplemental coding. The review provides a thematic synthesis of the extant literature, assessing the evidence base to identify gaps and opportunities for future research and collaboration with practitioners. We also contextualise recent research by tracing common threads of scholarly and practitioner discussions over the last two decades.
    Results: Publications on gender mainstreaming have increased, primarily from authors with European and USA academic affiliations and funding. Gender mainstreaming in the health and law and policy sectors has been researched most frequently. Trends in co-authorship suggest increasing collaboration among academics, yet limited collaboration among researchers and practitioners. Widespread low citation counts raise concerns about engagement with the literature. Key challenges in gender mainstreaming identified include conceptual clarity, academic-practitioner disjunctures, politics, leadership and organisational culture, men's roles, intersectionality, monitoring and evaluation, and public health sectoral concerns.
    Conclusions: The gender mainstreaming literature has expanded considerably over the last 25 years, yet there remain critical knowledge gaps, theoretical inconsistencies, weak research methods and evaluation processes, and implementation challenges. Funders, researchers, and practitioners have failed to prioritise bridging north-south and academic-practitioner divides in gender mainstreaming policy, programmes, and research. Integration of intersectionality also remains nascent. A more inclusive, collaborative, and structured research agenda on gender mainstreaming is needed to effect greater change in the face of persistent and new challenges. Engaging and empowering regional women's organisations, collaborative learning and research programmes, and joint research and advocacy groups; implementing gender-attuned editorial policies; and incorporating gender mainstreaming in educational curricula are recommended.
    DOI:  https://doi.org/10.7189/jogh.14.04011
  54. Front Med (Lausanne). 2023 ;10 1288014
    Characteristics of retracted research papers before and during the COVID-19 pandemic.
    Yuki Furuse.
       Objectives: During the COVID-19 pandemic, a large number of research papers were published, and some of them were retracted. The present study aims to reveal the characteristics of retracted papers before and during the pandemic.
    Methods: The study investigated 24,542,394 publications from 1999 to 2022 and analyzed the profiles of retracted papers from the perspectives of year, disease category, country, and journal.
    Results: Retraction rates were generally increasing at least until 2019, and were the highest for "Neoplasms." The number of publications for "Infections" and "Respiratory Tract Diseases" dramatically rose during the COVID-19 pandemic; however, the retraction rates in the two categories or of COVID-19-related papers were not especially high compared to other diseases. The association with retraction was strongest for China in most disease categories, whereas for COVID-19 papers, other countries showed higher retraction rates than China. In recent years, retracted papers have become less likely to be published in high-impact journals.
    Conclusion: The COVID-19 pandemic does not seem to affect the retractions of research papers much. We should keep monitoring retractions and analyze the effects of pandemics for better science.
    Keywords:  COVID-19; SARS-CoV-2; publication; research integrity; retraction
    DOI:  https://doi.org/10.3389/fmed.2023.1288014
  55. J Neurol Surg B Skull Base. 2024 Feb;85(1): 44-56
    A Decade of Global Skull Base Researchers: Authorship Trends from 3,295 Abstracts in the Journal of Neurological Surgery Part B: Skull Base.
    Rosemary T Behmer Hansen, Samantha D Palma, William A Blocher Iii, Ryan A Behmer Hansen, Justin L Gold, Stephen J Susman, Sai Batchu, Nicole A Silva, Angela M Richardson.
      Objective  The North American Skull Base Society (NASBS) multidisciplinary annual conference hosts skull base researchers from across the globe. We hypothesized that the work presented at the NASBS annual conference would reveal diverse authorship teams in terms of specialty and geography. Methods  In this retrospective review, abstracts presented at the NASBS annual meeting and subsequently published in the Journal of Neurological Surgery Part B: Skull Base between 01/01/2011 and 12/31/2020 were collected. Variables extracted included year, type of presentation, and author names and affiliations. Statistical analyses were performed with SPSS V23.0 with p -values less than 0.05 considered significant. Geographic heat maps were created to assess author distribution, and a network analysis was performed to display authorship collaboration between geographic regions. Results  Of 3,312 published abstracts, 731 (22.1%) had an author with an affiliation outside of the United States. Fifty-seven distinct countries were represented. Three-hundred twenty-four abstracts (9.8%) had authorship teams representing at least 2 different countries. The top five US states by abstract representation were Pennsylvania, California, New York, Ohio, and Minnesota. A majority of authors reported neurosurgery affiliations (56.7% first authors, 53.2% last authors), closely followed by otolaryngology (39.1% first authors, 41.5% last authors). No solo authors and very few (3.3%) of the first authors reported a departmental affiliation outside of otolaryngology or neurosurgery. Conclusions  Authors from many countries disseminate their work through poster and oral presentations at the NASBS annual meeting. Ten percent of abstracts were the product of international collaboration. Most authors were affiliated with a neurosurgery or otolaryngology department.
    Keywords:  abstract; authorship; conference; diversity; global neurosurgery; global surgery; presentation; skull base
    DOI:  https://doi.org/10.1055/a-2008-2884
  56. J Neurol Surg B Skull Base. 2024 Feb;85(1): 57-66
    A Decade of Global Skull Base Researchers: Gender Data from over 2,700 Abstract Authors in the Journal of Neurological Surgery Part B: Skull Base.
    Rosemary T Behmer Hansen, Ryan A Behmer Hansen, Justin L Gold, William A Blocher Iii, Samantha D Palma, Stephen J Susman, Sai Batchu, Nicole A Silva, Angela M Richardson.
      Objective  The North American Skull Base Society (NASBS) annual conference brings together skull base researchers from surgical and nonsurgical fields. Our objective was to quantify the contributions of the authors by gender, who presented their work at NASBS and were subsequently published in the Journal of Neurological Surgery Part B: Skull Base . Methods  Oral and poster abstracts presented at the NASBS annual meeting from January 1, 2011 to December 31, 2020 were extracted from the Journal of Neurological Surgery Part B: Skull Base. The genderize.io Web application programming interface was utilized to determine authorship gender. A minority of first and last authors had departmental affiliations listed; a subgroup analysis was performed of these authors. Results  Female gender was assigned to 498 (17.8%) of the 2,798 first authors and 269 (9.7%) of the 2,762 last authors. Female authorship has consistently increased over the last decade. Representation was higher in otolaryngology (23.3% of first authors, 12.1% of last authors; p  = 0.018) than neurosurgery (13.5% of first authors, 4.3% of last authors; p  = 0.004). Female researchers were not less likely than their male counterparts to receive prestigious oral presentations. Of the 52 total countries represented, 20 (38.5%) had at least one female first author. Representation varied dramatically between countries. Conclusion  The NASBS' efforts have undoubtedly contributed to these impressive strides toward gender parity. More work is needed to ensure that the best and the brightest, regardless of background, continue to contribute to skull base surgery research.
    Keywords:  abstract; authorship; gender; otolaryngology; skull base
    DOI:  https://doi.org/10.1055/a-1978-9487
  57. Environ Res. 2024 Jan 23. pii: S0013-9351(24)00184-1. [Epub ahead of print] 118280
    A critical review on the ecotoxicity of heavy metal on multispecies in global context: A bibliometric analysis.
    Bhagyudoy Gogoi, Shiva Aley Acharjee, Pranjal Bharali, Viphrezolie Sorhie, Bendangtula Walling, Alemtoshi.
      Heavy metals (HMs) have become a significant concern in the current era, with deleterious effects on diverse living organisms when exposed beyond threshold concentrations. Both nature and human beings have been constantly casting out HMs into environmental matrices through various activities. Innumerable cases of threatened diseases such as cancer, respiratory ailments, reproductive defects, skin diseases, and several others have been a cause of significant concern for humans as the number of instances has been increasing with each decade. HMs migrates via several pathways to infiltrate biological organisms and amass within them. Even though numerous treatment approaches are available for remediating HM pollution, however, they are expensive, along with other setbacks. Due to such constraints, combating HM contamination requires environmentally conscious strategies like bioremediation, which employs an array of biological systems to remove HMs from the environment. Nonetheless, to address the current global HM pollution situation, it is critical to comprehend not only how these hazardous HMs cause toxicity in various living organisms but also the knowledge gaps that currently exist concerning the subject of HM ecotoxicity. In the present investigation, data was extracted from Google Scholar using software program called Harzing's Publish or Perish. The collected information has been subsequently displayed as a network file using the VOSViewer software tool. Thus, the current review presents a significant insight with the inclusion of a readily accessible bibliometric analysis to comprehend the present status of HMs research, global research trends, existing knowledge discrepancies, and research challenges. Further, it also provides an in-depth review of HMs ecotoxicity, with a focus on arsenic (As), cadmium (Cd), and lead (Pb). Thus, as indicated by the bibliometric study, the present review will assist future investigators studying HMs ecotoxicity by providing baseline data concerning a wide range of living organisms and by addressing research gaps.
    Keywords:  Bibliometrics; Heavy metals (HMs); Oxidative stress; Technology; Toxicity
    DOI:  https://doi.org/10.1016/j.envres.2024.118280
  58. Environ Sci Pollut Res Int. 2024 Jan 25.
    Energy retrofitting strategies for existing buildings in Malaysia: A systematic review and bibliometric analysis.
    Muhammad Tarique Lakhiar, Shalini Sanmargaraja, AbdulLateef Olanrewaju, Chong Hooi Lim, Vignes Ponniah, Anselm Dass Mathalamuthu.
      This paper comprehensively examines passive and active energy retrofit strategies as a highly effective approach for reducing building energy consumption and mitigating CO2 emissions while enhancing comfort and sustainability. The paper further examines energy simulation software and assesses the integration of renewable energy systems in building to improve energy efficiency. The review used the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) methodology, ensuring a rigorous and comprehensive analysis. In addition, the study utilized bibliometric analysis with VOSviewer to provide valuable insights into the research trends and influential publications in building energy retrofits. Bibliometric analysis reveals strong collaboration among 17 authors, emphasizing their significant contributions. Keywords like energy retrofitting and efficiency are prominent, indicating their importance in academic literature. Findings show passive strategies are more effective in reducing energy consumption, though a combined approach with active strategies can yield optimal results. Retrofitting presents challenges, such as substantial initial costs and regulatory barriers. User acceptance is crucial, considering potential disruptions. The review highlights the importance of energy simulation software, with tools like EnergyPlus, eQUEST, and IES VE identified for evaluating and identifying cost-effective retrofit measures in building performance. By providing comprehensive insights into the various strategies and tools available for retrofitting buildings to achieve energy efficiency and sustainability goals, this review serves as an authoritative resource for building owners, managers, and professionals in the building industry. It offers invaluable guidance for informed decision-making and facilitates implementing effective, energy-efficient, and sustainable building retrofitting practices.
    Keywords:  Commercial and residential sectors; Energy efficiency; Energy saving; Greenhouse gases; Passive and active strategies; Renewable energy systems
    DOI:  https://doi.org/10.1007/s11356-024-32020-x
  59. Nurs Open. 2024 Jan;11(1): e2050
    A text mining and network analysis of topics and trends in major nursing research journals.
    Beratiye Oner, Orhan Hakli, Ferhat D Zengul.
       AIM: This study is set to determine the main topics of the nursing field and to show the changing perspectives over time by analysing the abstracts of several major nursing research journals using text mining methodology.
    DESIGN: Text mining and network analysis.
    METHODS: Text analysis combines automatic and manual operations to identify patterns in unstructured data. Detailed searches covering 1998-2021 were conducted in PubMed archives to collect articles from six nursing journals: Journal of Advanced Nursing, International Journal of Nursing Studies, Western Journal of Nursing Research, Nursing Research, Journal of Nursing Scholarship and Research in Nursing and Health. This study uses a four-phase text mining and network approach, gathering text data and cleaning, preprocessing, text analysis and advanced analyses. Analyses and data visualization were performed using Endnote, JMP, Microsoft Excel, Tableau and VOSviewer versions. From six journals, 17,581 references in PubMed were combined into one EndNote file. Due to missing abstract information, 2496 references were excluded from the study. The remaining references (n = 15,085) were used for the text mining analyses.
    RESULTS: Eighteen subjects were determined into two main groups; research method topics and nursing research topics. The most striking topics are qualitative research, concept analysis, advanced practice in the downtrend, and literature search, statistical analysis, randomized control trials, quantitative research, nurse practice environment, risk assessment and nursing science. According to the network analysis results, nursing satisfaction and burnout and nursing practice environment are highly correlated and represent 10% of the total corpus. This study contributes in various ways to the field of nursing research enhanced by text mining. The study findings shed light on researchers becoming more aware of the latest research status, sub-fields and trends over the years, identifying gaps and planning future research agendas. No patient or public contribution.
    Keywords:  network analysis; nursing; research; text mining; topics; trends
    DOI:  https://doi.org/10.1002/nop2.2050
  60. Turk Patoloji Derg. 2024 Jan 24.
    Are We Where We Want to Be in Undergraduate Pathology Education?
    Sibel Sensu, Nusret Erdogan.
       OBJECTIVE: This review which aims to examine the recent and current status of pathology education in medical schools, and covers the publications related to undergraduate pathology education published between 2010 January and June 2023.
    MATERIAL AND METHOD: A search was performed through PubMed, Google Scholar, Semantic Scholar, and Ulakbim search engines for the Science Citation Index, Science Citation Index Expanded, Emerging Sources Citation Index, Directory of Open Access Journals, Scopus, PubMed as well as TR Dizin indexed articles. The findings are categorized into two periods as 2010 January - 2020 April (pre-COVID-19 pandemic) and May 2020 - 2023 June. A total of 24 reviews/editorials/letters to the editor and 63 research articles in the pre-pandemic period and 11 reviews/ editorials/ letters to the editor and 35 research articles between 2020 May and 2023 June are included in the analysis.
    RESULTS: Currently, medical education generally depends on core education programs with defined learning objectives and outcomes. Moreover, problem-based, case-based, and team-based interactive learning are being used along with traditional didactic courses. Additionally, digital/ web-based/remote education methods have gained prominence after the COVID-19 pandemic. The virtual or augmented reality and 3D drawing applications are offered as a solution for the autopsy and macroscopy courses. A scarce number of publications are found on measuring and evaluating the effectiveness of learning.
    CONCLUSION: Artificial intelligence in pathology education is a topic that looks likely to become important in the near future. National and international comprehensive standardization is a necessity. A joint effort and collective intelligence are needed to achieve the desired goals in undergraduate pathology education.
    DOI:  https://doi.org/10.5146/tjpath.2023.13048
  61. Stud Health Technol Inform. 2024 Jan 25. 310 429-433
    Digital Health for Myocardial Infarction: Research Topics and Trends.
    Melissa Pelly, Farhad Fatehi, Mahnaz Samadbeik, Danny Liew, Antonio Verdejo-Garcia.
      We aimed to map the topics and trends of research on digital health for myocardial infarction over the past ten years. This can inform future research directions and newly emerging topics for myocardial infarction care, diagnosis and monitoring. The Web of Science database was searched for papers related to digital health for myocardial infarction. 1,344 retrieved records were used for visualisation through bibliometrics and co-occurrence network analysis of keywords. Our mapping revealed several emerging topics in recent years, including artificial intelligence and deep learning. Higher emphasis on automated and artificially intelligent digital health systems in recent years can inform future clinical practice and research directions for myocardial infarction.
    Keywords:  Artificial intelligence; chronic care management; data visualisation; digital health
    DOI:  https://doi.org/10.3233/SHTI231001
  62. Front Plant Sci. 2023 ;14 1228850
    Cereal-legume intercropping: a smart review using topic modelling.
    Sofie Landschoot, Riccardo Zustovi, Kevin Dewitte, Nicola P Randall, Steven Maenhout, Geert Haesaert.
       Introduction: Over the last decade, there has been a growing interest in cereal-legume intercropping for sustainable agriculture. As a result numerous papers, including reviews, focus on this topic. Screening this large amount of papers, to identify knowledge gaps and future research opportunities, manually, would be a complex and time consuming task.
    Materials and methods: Bibliometric analysis combined with text mining and topic modelling, to automatically find topics and to derive a representation of intercropping papers as a potential solution to reduce the workload was tested. Both common (e.g. wheat and soybean) as well as underutilized crops (e.g. buckwheat, lupin, triticale) were the focus of this study. The corpus used for the analysis was retrieved from Web of Science and Scopus on 5th September 2022 and consisted of 4,732 papers.
    Results: The number of papers on cereal-legume intercropping increased in recent years, with most studies being located in China. Literature mainly dealt with the cereals maize and wheat and the legume soybean whereas buckwheat and lupin received little attention from academic researchers. These underutilized crops are certainly interesting to be used as intercropping partners, however, additional research on optimization of management and cultivar's choice is important. Yield and nitrogen fixation are the most commonly studied traits in cereal-legume intercropping. Last decade, there is an increasing interest in climate resilience, sustainability and biodiversity. Also the term "ecosystem services" came into play, but still with a low frequency. The regulating services and provisioning services seem to be the most studied, in contrast terms related to potential cultural services were not encountered.
    Discussion: In conclusion, based on this review several research opportunities were identified. Minor crops like lupin and buckwheat need to be evaluated for their role as intercropping partners. The interaction between species based on e.g. root exudates needs to be further unraveled. Also diseases, pests and weeds in relation to intercropping deserve more attention and finally more in-depth research on the additional benefits/ecosystem services associated with intercropping systems is necessary.
    Keywords:  cereal; intercrop; legume; text mining; topic model
    DOI:  https://doi.org/10.3389/fpls.2023.1228850
  63. Front Pediatr. 2023 ;11 1308889
    Global research hotspots and trends in non-surgical treatment of adolescent idiopathic scoliosis over the past three decades: a bibliometric and visualization study.
    Jie Xu, Meng Chen, Xin Wang, Lin Xu, Xiaobing Luo.
       Background: In recent years, research on the non-surgical treatment of AIS has been increasingly conducted. To the best of our knowledge, this field doesn't yet have a comprehensive and structured pulse combing analysis. In order to provide inspiration and resources for subsequent researchers, we thus reviewed the literature studies on the non-surgical treatment of AIS from the previous thirty years and highlighted the hotspots and frontiers of research in this field.
    Methods: Main using Citespace 6.1 software, the data from the core dataset of the WOS database pertaining to the non-surgical management of AIS from 1990 to 2022 was gathered, displayed, and analyzed.
    Results: 839 papers in all were included in the literature. With 215 papers, the USA came in first place. Chinese Univ Hong Kong ranked first with 32 papers. Research hotspots are adolescent idiopathic spondylitis, Schroth-based physiotherapy-specific exercise efficacy, curve development, Cobb angle, TLSO brace-based clinical efficacy, quality of life, reliability, health-related quality of life questionnaires, finite element biomechanical models, follow-up, and clinical guidelines.
    Conclusion: There aren't many studies that compare the clinical effectiveness of various non-surgical treatments, and because of variations in inclusion eligibility standards and outcome measures, these studies cannot be directly compared. In addition, the inconsistency of existing growth potential and progression risk assessment systems further affects comparative studies of clinical efficacy; it is recommended to establish primary assessment indicators centered on patient treatment outcomes (including appearance, disability, pain, and quality of life), as well as standardized scoliosis progression risk assessment criteria.
    Keywords:  Sports/Rehabilitation/Sport; adolescent idiopathic scoliosis; bibliometric analysis; brace; physiotherapy scoliosis-specific exercise; rehabilitation studies published in Psychology/Education/Social
    DOI:  https://doi.org/10.3389/fped.2023.1308889
  64. Children (Basel). 2024 Jan 18. pii: 119. [Epub ahead of print]11(1):
    Fostering Motivation: Exploring the Impact of ICTs on the Learning of Students with Autism.
    José María Fernández-Batanero, Marta Montenegro-Rueda, José Fernández-Cerero, Eloy López-Meneses.
      Currently, the use of digital tools has led to significant changes in the educational system, favouring equity and the inclusion of students with educational needs. In this context, students with autism spectrum disorder (ASD) benefit from using these electronic devices to improve their learning experience. This study focuses on conducting a bibliometric analysis of the impact of information and communication technologies on the learning of students with ASD, with the aim of addressing two research questions. Through the analysis of three databases (Scopus, Dialnet, and Web of Science), a total of 24 articles related to the subject were collected. The results show that the use of different technological devices has numerous benefits for these students. Among the most prominent are the use of augmented reality and educational robotics, mainly providing improvements in academic performance, motivation and improved retention of knowledge acquired in the classroom. In conclusion, the clear need to train teachers in digital competencies and to intensify efforts in this line of research in order to improve the education of students, as well as to enrich the knowledge available to the scientific community, is highlighted.
    Keywords:  ASD; ICT; motivation; student
    DOI:  https://doi.org/10.3390/children11010119
  65. Cancers (Basel). 2024 Jan 15. pii: 372. [Epub ahead of print]16(2):
    Multi-Algorithm Analysis Reveals Pyroptosis-Linked Genes as Pancreatic Cancer Biomarkers.
    Kangtao Wang, Shanshan Han, Li Liu, Lian Zhao, Ingrid Herr.
      Pancreatic ductal adenocarcinoma (PDAC) is often diagnosed at late stages, limiting treatment options and survival rates. Pyroptosis-related gene signatures hold promise as PDAC prognostic markers, but limited gene pools and small sample sizes hinder their utility. We aimed to enhance PDAC prognosis with a comprehensive multi-algorithm analysis. Using R, we employed natural language processing and latent Dirichlet allocation on PubMed publications to identify pyroptosis-related genes. We collected PDAC transcriptome data (n = 1273) from various databases, conducted a meta-analysis, and performed differential gene expression analysis on tumour and non-cancerous tissues. Cox and LASSO algorithms were used for survival modelling, resulting in a pyroptosis-related gene expression-based prognostic index. Laboratory and external validations were conducted. Bibliometric analysis revealed that pyroptosis publications focus on signalling pathways, disease correlation, and prognosis. We identified 357 pyroptosis-related genes, validating the significance of BHLHE40, IL18, BIRC3, and APOL1. Elevated expression of these genes strongly correlated with poor PDAC prognosis and guided treatment strategies. Our accessible nomogram model aids in PDAC prognosis and treatment decisions. We established an improved gene signature for pyroptosis-related genes, offering a novel model and nomogram for enhanced PDAC prognosis.
    Keywords:  LDA analyses; bibliometric analysis; machine learning; pancreatic cancer; pyroptosis
    DOI:  https://doi.org/10.3390/cancers16020372
  66. Am Psychol. 2024 Jan 25.
    I forgot that you existed: Role of memory accessibility in the gender citation gap.
    Veronica X Yan, Katherine Muenks, Marlone D Henderson.
      Recent studies have found a citation gap in psychology favoring men. This citation gap is subsequently reflected in differences in h-index scores, a crude measure but important one for impact on career advancement. We examine a potential reason for the gap: that male researchers are more likely to come to mind than female researchers (i.e., a difference in memory accessibility). In a survey, faculty from psychology departments in R1 institutions in the United States listed up to five names they considered experts in their field and up to five names they considered rising stars (defined as pretenure) in their field. Results revealed that the proportion of female experts recalled by women generally matched the percentage of more senior female faculty at R1 institutions, whereas the proportion recalled by men was much lower as compared to this baseline. With rising stars, we observed both underrepresentation of women from male participants and, unexpectedly, overrepresentation of women from female participants, as compared to the percentage of more junior female faculty at R1 institutions. For both experts and rising stars, male names were also more likely to be generated earlier in lists by male respondents, but women did not vary in the order in which they listed women versus men. Despite the differences in recall observed in our data, there was no such gap in name recognition, suggesting that the gap is one of accessibility-who comes to mind. Implications and recommendations for psychology researchers are discussed. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
    DOI:  https://doi.org/10.1037/amp0001299
  67. Foods. 2024 Jan 17. pii: 297. [Epub ahead of print]13(2):
    Regional Agriculture and Food Systems Amid the COVID-19 Pandemic: The Case of the Near East and North Africa Region.
    Hamid El Bilali, Tarek Ben Hassen.
      The COVID-19 pandemic affected agri-food systems worldwide. However, while the impacts differed from one country/region to another, the scholarly literature seems to focus on developed countries in the Global North. Consequently, this review scrutinizes the literature on the pandemic's impacts in the Near East and North Africa (NENA) region. A search on the Web of Science in March 2023 generated 334 documents, of which 151 were eligible for inclusion in the systematic review. According to the bibliometric analysis, the most active nations are Saudi Arabia, Egypt, Jordan, the United Arab Emirates, and Lebanon. In general, the coverage of studies is better in the Gulf region than in the less developed countries of North Africa and those suffering from wars (cf. Libya, Syria, and Yemen). Studies generally focus on crop production and the downstream food chain (cf. distribution and consumption). While the pandemic influenced every pillar of food security, this research concentrates on access and utilization. Meanwhile, the lion's share of the literature deals with the pandemic's socio-economic effects, especially those linked to food (in)security and health. The pandemic, which laid bare the agri-food system vulnerabilities, should be seized to foster the transition towards more resilient agri-food systems in the NENA region.
    Keywords:  Arab; MENA; Maghreb; NENA; bibliometrics; coronavirus; food security; resilience; sustainable agriculture; sustainable food system
    DOI:  https://doi.org/10.3390/foods13020297
  68. Work. 2024 Jan 18.
    Digital technologies (DTs) for safety education and training in construction.
    Vigneshkumar Chellappa, Peter Mésároš, Marcela Spišáková, Pavol Kaleja, Matej Špak.
       BACKGROUND: Digital technologies (DTs) have gained recognition for educating and training individuals, covering multiple areas in construction sector to enhance safety performance.
    OBJECTIVE: The objective of this study was to conduct a systematic literature review (SLR) focusing on DTs utilized for safety education and training in the construction sector since 2000 and explore their various application areas.
    METHODS: Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed to conduct SLR and fifty-nine articles were identified. This study describes the research trends through bibliometric analysis, encompassing aspects such as annual publication counts, document sources, influential authors and documents, countries of origin, and prevalent research areas.
    RESULTS: The results revealed that immersive virtual reality (VR) technology has seen extensive utilization in educating and training individuals. In the context of application areas, most DTs concentrated on augmenting individuals' proficiency in recognizing hazards.
    CONCLUSION: The findings summarized the primary research domains, deliberated upon prevailing research gaps, and proposed forthcoming directions for applying DTs in safety training. The suggested future directions can potentially enhance safety training effectiveness within the construction firm.
    Keywords:  Safety education; construction firm; digital technologies; extended reality; workplace safety
    DOI:  https://doi.org/10.3233/WOR-220698
  69. Sci Rep. 2024 01 23. 14(1): 1989
    Visualization analysis of research progress for walkability.
    Xuan Li, Dan Xie, Zhiyu Zhou, Xin Zhang, Rui Li, Jiayi Li, Zeyu Chen, Jiayu Zhang.
      The study of walkability is of great significance to the construction of healthy cities. In this paper, taking 1283 articles of walkability, which were included in Web of Science, as the research object. This paper adopts to analysis the research progress by using the method of scientometrics and knowledge networks analysis. Objectively and systematically analyze the research progress of walkability abroad from the aspects of publication overview, knowledge foundation, research direction and hot spots, etc. It is found that foreign researches on walkability mainly include three core directions: walkability and physical activity, walkability evaluation, walkability and urban design. Among them, walkability and physical activity orientation have been studied from various perspectives, such as various groups, various environmental types, different behavioral patterns and various chronic diseases. With the increasingly prominent urbanization problems and the rapid development of new technologies, multiple data, new methods and interdisciplinary cooperation will actively promote the vigorous development of walking suitability research.
    DOI:  https://doi.org/10.1038/s41598-024-52227-9
  70. JAMA Surg. 2024 Jan 24.
    National Institutes of Health Funding for Surgeon-Scientists in the US-An Update and an Expanded Landscape.
    Lindsay A Demblowski, Seth M Steinberg, Rebecca A Meseroll, George M Santangelo, Martha A Zeiger.
       Importance: Current reports suggest that the surgeon-scientist phenotype is significantly threatened. However, a significant increase in the proportion of surgeons in the workforce funded by the National Institutes of Health (NIH) from 2010 (0.5%) to 2020 (0.7%) was recently reported and showed that surgeons primarily performed basic science research (78% in 2010; 73% in 2020) rather than clinical research.
    Objective: To provide an update on the status of surgeons funded by the NIH for fiscal year (FY) 2022.
    Evidence Review: NIH-funded surgeons were identified in FY2012 and FY2022, including those who were awarded grants with more than 1 principal investigator (PI) by querying the internal database at the NIH. The main outcome for this study was the total number of NIH-funded surgeons in FY2012 and FY2022, including total grant costs and number of grants. The secondary analysis included self-reported demographic characteristics of the surgeons in FY2022. The research type (basic science vs clinical) of R01 grants was also examined.
    Findings: Including multiple PI grants, 1324 surgeon-scientists were awarded $1.3 billion in FY2022. Women surgeons increased to 31.3% (339 of 1084) of the population of surgeon PIs in FY2022 compared with 21.0% (184 of 876) in FY2012. Among surgeon PIs awarded grants, a total of 200 (22.8%) were Asian, 35 (4.0%) were Black or African American, 18 (2.1%) were another race (including American Indian or Alaska Native, Native Hawaiian or Other Pacific Islander, and more than 1 race), and 623 (71.1%) were White. A total of 513 of 689 R01 grants (74.5%) were for basic science, 131 (19.0%) were for clinical trials, and 45 (6.5%) were for outcomes research.
    Conclusions and Relevance: NIH-funded surgeons are increasing in number and grant costs, including the proportion of women surgeon PIs, and are representative of the diversity among US academic surgical faculty. The results of this study suggest that despite the many obstacles surgeon-scientists face, their research portfolio continues to grow, they perform a myriad of mostly basic scientific research as both independent PIs and on multidisciplinary teams.
    DOI:  https://doi.org/10.1001/jamasurg.2023.7167
  71. Int Wound J. 2024 Jan;21(1): e14644
    State of the art, trends, hotspots, and prospects of injection materials for controlling bleeding.
    Changsheng Feng, Liang Yang.
      Traumatic haemorrhage is a prevalent clinical condition, and effective and timely haemostasis is crucial for the preservation of patients' lives. In recent years, injectable hemostatic materials have gained significant attention due to their excellent hemostatic efficacy, biocompatibility, and biodegradability, making them widely applied in the treatment of incompressible traumatic haemorrhage. Systematic analysis of injectable hemostatic materials is crucial for research in this area. This article provides a comprehensive review of the development and research trends of injectable hemostatic materials over the past 20 years using visualization techniques. Analysis of collaboration and co-citation networks revealed localized research collaboration networks, highlighting the need for enhanced international collaboration in the field of injectable hemostatic materials. Current research focuses primarily on hemostatic materials, hemostatic processes, and hemostatic mechanisms. Injectable hemostatic materials with excellent performance offer promising strategies for wound healing. This review provides a comprehensive and systematic summary of injectable hemostatic materials, offering valuable guidance for the development and clinical application of novel injectable hemostatic materials. Additionally, visualized methodology and mapping analysis are effective data mining methods that provide approaches and strategies for clear knowledge network analysis. These methods facilitate better understanding and interpretation of research dynamics in the field of injectable hemostatic materials, thereby guiding and inspiring future research.
    Keywords:  haemostasis; injectable; traumatic haemorrhage; wound healing
    DOI:  https://doi.org/10.1111/iwj.14644
  72. World Neurosurg. 2024 Jan 22. pii: S1878-8750(24)00107-4. [Epub ahead of print]
    Trends in Female Authorship over 5-year Publication History in Neurovascular surgery.
    Alice Jm Jelmoni, Luca Mascaro, Carlotta Mariola, Marian Mora Conde, Daniel Uralov, Francesca Caniglia, Kamel Chebaro, Elena Rosellini, Ismail Zaed, Davide Milani, Delia Cannizzaro.
      
    Keywords:  Authorship; Bibliometrics; Female; Gender; Interventional Neuroradiology; Neurosurgery; Vascular
    DOI:  https://doi.org/10.1016/j.wneu.2024.01.095
  73. Health Res Policy Syst. 2024 Jan 26. 22(1): 16
    Investigating the citing communities around three leading health-system frameworks.
    George Weisz, Jonathan Harper.
      Of numerous proposed frameworks for analyzing and impacting health systems, three stand out for the large number of publications that cite them and for their links to influential international institutions: Murray and Frenk (Bull World Health Organ 78:717-31, 2000) connected initially to the World Health Organization (WHO) and then to the Global Burden of Disease Project; Roberts et al. (Getting health reform right: a guide to improving performance and equity, Oxford University Press, Oxford, 2004) sponsored by the World Bank/Harvard Flagship Program; and de Savigny and Adam (Systems thinking for health systems strengthening, WHO, 2009) linked to the WHO and the Alliance for Health Policy and Systems Research. In this paper, we examine the citation communities that form around these works to better understand the underlying logic of these citation grouping as well as the dynamics of Global Health research on health systems. We conclude that these groupings are largely independent of one another, reflecting a range of factors including the goals of each framework and the problems that it was meant to explore, the prestige and authority of institutions and individuals associated with these frameworks, and the intellectual and geographic proximity of the citing researchers to each other and to the framework authors.
    Keywords:  Alliance for Health Policy and Systems Research; Citation community; Global Burden of Disease; Harvard-World Bank Flagship Program; Health Policy and Systems Research; World Health Organization
    DOI:  https://doi.org/10.1186/s12961-023-01075-6
  74. Int J Immunopathol Pharmacol. 2024 Jan-Dec;38:38 3946320241226506
    Corrigendum to "Bibliometric and visual analyses of trends in the field of T cell exhaustion research: Findings from 2000 to 2022".
      
    DOI:  https://doi.org/10.1177/03946320241226506
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