bims-evares Biomed News
on Evaluation of research
Issue of 2023‒04‒09
fifty-six papers selected by
Thomas Krichel
Open Library Society


  1. Ann Transl Med. 2023 Mar 15. 11(5): 204
      Background: Tissue expansion (TE) has attracted significant attention from researchers over the past decade. However, there are currently no bibliometric analyses in this field. We aimed to quantitatively and visually analyze the literature to explore the hotspots and frontiers in TE research.Methods: We extracted all the documents on this topic published from the Web of Science Core Citation (WOSCC) database between 2012 and 2021. CiteSpace (version 5.8 R3) and VOSviewer (version 1.6.18) were used to perform the visualization analysis.
    Results: A total of 1,085 documents were included in the analysis. The publication trend fluctuated over time. The United States led the research, and Harvard University was the most productive institution. Plastic and Reconstructive Surgery published the largest number of documents and had the most citations. Kim JYS was the most prolific and most cited author. The high-frequency keywords were "complications", "breast reconstruction", "outcomes", "tissue expander", "mastectomy", and "acellular dermal matrix" (ADM). "Surgical site infection", "tissue expander/implant", "bilateral prophylactic mastectomy", and "activated controlled expansion" were the keywords with the strongest citation bursts until 2021.
    Conclusions: This study provided a complete analysis of the research on TE. The effect of ADM on the complication rates after breast reconstruction is the current hotspot of TE research in surgery. Patient-activated controlled expansion might be a promising future research direction for TE.
    Keywords:  Bibliometric analysis; breast reconstruction; defect reconstruction; tissue expansion (TE)
    DOI:  https://doi.org/10.21037/atm-22-3643
  2. J Clin Exp Dent. 2023 Mar;15(3): e217-e224
      Background: Denture stomatitis is a clinical condition that affects people who wear removable maxillary dentures. It causes redness, soreness, and erythema and ultimately affects the general condition of the patient. The objective of this study was to analyze the leading countries, journals, organizations, and authors and the frequently used keywords associated with denture stomatitis.Material and Methods: A bibliometric analysis of publications indexed in the Scopus database was conducted, and the article titles, abstracts, and keywords were analyzed using the VOSviewer software. Denture stomatitis-related publications from 1960 to 2021 were collected. This study included only research papers published in English with "article" as the paper type and dentistry as the subject area.
    Results: Data from a total of 461 articles and 10 different journals were obtained. The papers were published in 64 different countries. Brazil and the United States of America were the top contributing countries, and the University of Sydney was the leading organization. Papers published in the Journal of Oral Rehabilitation received the highest number of citations, while author Gordon Ramage from the University of Glasgow received the highest number of citations.
    Conclusions: The bibliometric analysis revealed that the number of denture stomatitis-related publications indexed in the Scopus database is increasing globally. Since 2007, there has been an increase in research interest regarding denture stomatitis, with more publications from several countries expected to be published in different journals. Key words:Bibliometric analysis, denture, candida, VOSviewer, maxilla.
    DOI:  https://doi.org/10.4317/jced.60249
  3. Front Res Metr Anal. 2023 ;8 1100845
      Based on the polar polynya-related 1,677 publications derived from the Web of Science from 1980 to 2021, this study analyses the scientific performance of polar polynya research with respect to publication outputs, scientific categories, journals, productive countries and partnerships, co-cited references, bibliographic documents and the thermal trends of keywords. The number of publications and citations on polar polynya has increased 17.28 and 11.22% annually since the 1990s, respectively, and those numbers for Antarctic polynya have surpassed that of the Arctic polynya since 2014. Oceanography, geosciences multidisciplinary, and environmental sciences were the top 3 scientific categories in the Arctic and Antarctic polynya research field. Nevertheless, ecology and meteorology are gaining ground in the Arctic and the Antarctic recently. The Journal of Geophysical Research-Oceans accommodated most publications for both polar regions, followed by Deep-Sea Research Part II-Topical Studies in Oceanography and Polar Biology. The Continental Shelf Research and Ocean Modeling were favored journals in Arctic and Antarctic polynya research, respectively. The USA dominated the polar polynya study field with 31.74%/43.60% publications on the Arctic/Antarctic polynya research, followed by Canada (40.23%/4.32%) and Germany (17.21%/11.22%). Besides, Australia occupied the second most popular position in the Antarctic polynya research. The keywords analysis concluded that the polynya topics that generated the most interest were altered from model to climate change in the Arctic and ocean water and glacier in the Antarctic over time. This study gives a summary of the polar polynya scientific field through bibliometric analysis which may provide reference for future research.
    Keywords:  Antarctic; Arctic ocean; polynya oceanography; research trends; sea ice
    DOI:  https://doi.org/10.3389/frma.2023.1100845
  4. Front Endocrinol (Lausanne). 2023 ;14 1144465
      Background: Subacute thyroiditis (SAT) is the most prevalent self-limiting thyroid disease that causes pain, accounting for about 5% of all clinical thyroid disorders. Numerous clinically noteworthy results have been published in this area over the last 20 years. However, no article has comprehensively assessed the relevant literature yet. We conducted a bibliometric analysis of SAT to provide light on the dynamic nature of scientific advancement and aid researchers in gaining a global perspective while examining research core themes and hotspots.Methods: SAT-related articles and reviews from 2001 to 2022 were retrieved from the Science Citation Index-Expanded of Web of Science Core Collection (WoSCC). We analyzed current research trends and hotspots in this area using CiteSpace and Vosviewer.
    Results: A total of 568 studies associated with SAT research were published in 282 academic journals by 2,473 authors in 900 institutions from 61 countries/regions. The United States was a crucial link in inter-country/region collaboration and was the most frequently involved country in international cooperation. The University of Missouri System was the top organization, and Braley-Mullen H. was the most productive researcher. Thyroid published the most papers, with 36 publications. The most co-cited article was "Clinical features and outcome of subacute thyroiditis in an incidence cohort: Olmsted County, Minnesota, study" (by Fatourechi V., 2003). The clustered network and timeline view of keywords showed that the prevalence, diagnosis, and treatment of SAT were the research core themes during the past 20 years. Analysis of keyword bursts indicated that the clinical characteristic and the influence of COVID-19 on SAT appeared to be the current research hotspots.
    Conclusion: This bibliometric analysis conducted a thorough review of the SAT research. The clinical characteristics and the genetic background of SAT under the influence of COVID-19 are current research hotspots. However, there is still a need for further study and global collaboration. Our findings can aid researchers in understanding the current status of SAT research and immediately pinpoint new directions for further investigation.
    Keywords:  CiteSpace; VOSviewer; bibliometric analysis; hot spots; subacute thyroiditis (SAT)
    DOI:  https://doi.org/10.3389/fendo.2023.1144465
  5. Clin Orthop Surg. 2023 Apr;15(2): 227-233
      Background: This study aimed to investigate the characteristics of research articles and research trends in computer-assisted orthopedic surgery (CAOS) by conducting bibliometric analyses.Methods: CAOS-related research articles published in international journals from 2002 to 2021 were collected using the PubMed database and analyzed using the bibliometric method. Their publication year, journal name, corresponding author's country name, and the number of citations of all collected articles were noted. Contents of the articles were analyzed to evaluate the time point and anatomical site at which the digital technique was applied. Further, the 20-year period was divided into two halves of 10 years each to analyze the research trends.
    Results: A total of 639 CAOS-related articles were identified. An average of 32.0 CAOS-related articles were published annually, with an average of 20.6 and 43.3 published in the first half and second half, respectively. Of all articles, 47.6% were published in the top 10 journals, and 81.2% were written in the top 10 countries. The total numbers of citations were 11.7 and 6.3 in the first and second halves, respectively, but the average annual number of citations was higher in the second half than in the first one. Articles on application of digital techniques during surgery were 62.3% and those on pre-surgery application were 36.9%. Further, articles in the knee (39.0%), spine (28.5%), and hip and pelvis (21.5%) fields accounted for 89.0% of the total publications. But the increase in publications in the said period was highest in the fields of the hand and wrist (+1,300.0%), ankle (+466.7%), and shoulder (+366.7%).
    Conclusions: Over the last 20 years, the publication of CAOS-related research articles in international journals has grown steadily. Although the knee, spine, hip, and pelvis fields account for most CAOS-related research, research in new fields is also increasing. This study analyzed the types of articles and trends in CAOS-related research and provided useful information for future research in the field of CAOS.
    Keywords:  Bibliometrics; Computer-assisted surgery; Orthopedics; Research
    DOI:  https://doi.org/10.4055/cios21217
  6. Eur Rev Med Pharmacol Sci. 2023 Mar;pii: 31752. [Epub ahead of print]27(6): 2189-2199
      OBJECTIVE: Previous trials demonstrated the effectiveness of exercise in improving pain and functional impairment in patients with knee osteoarthritis (KOA). However, a bibliometric analysis of top-cited papers on exercise treatment for KOA has not yet been conducted. The aim of the present study was to critically analyze the bibliometric characteristics of the most frequently cited articles on exercise treatment for KOA.MATERIALS AND METHODS: Publications about exercise treatment for KOA from 2000 to 2021 were searched from the Web of Science database. Two authors independently collected 100 top-cited articles, and a consensus was reached to form the final list. The title, journal, author, year of publication, country and institution of origin, total citations, citations in 2021, main topics, research nature, and level of evidence were extracted, and the publication trends in exercise treatment for KOA were evaluated.
    RESULTS: A total of 1,258 papers were retrieved from the database. According to the final list, clinical research accounted for 81% of the studies, but no statistical difference in the number of citations was found among the four types of articles (p=0.194). Seventy articles had a level of evidence of Ib, and no statistical differences in citations were found per level of evidence (p=0.767). Most of the top-cited articles were published between 2005-2014, and Dr Messier was the prominent writer in this field.
    CONCLUSIONS: This bibliometric study is the first to identify the most cited papers in exercise treatment for KOA research. Traditional Chinese exercise, comorbidity, and exercise adherence may be the next popular research trends that will receive more attention in the future.
    DOI:  https://doi.org/10.26355/eurrev_202303_31752
  7. Neurospine. 2023 Mar;20(1): 374-389
      OBJECTIVE: The ever-growing number of articles related to full-endoscopic spine surgery published in the last few decades presents a challenge which is perplexing and time-consuming in identifying the current research status. The study aims to identify and analyze the most cited works related to full-endoscopic decompression spine surgery, compare the articles published by different publishers and area, and show the current publication status of full-endoscopic research.METHODS: Using Bibliometrix, CiteSpace, and VOSviewer, we analyzed the bibliometric data selected from the Web of Science database between 1992 and 2022. Spine has the highest H-index with the most-cited journal in the field of full-endoscopic decompression spine surgery. China ranked as the most productive country, whereas the most cited with high H-index papers came from South Korea. For the author analysis, Yeung AT, Ruetten S, Hoogland T, Ahn Y, Choi G, and Mayer HM were the most impactful authors in the global and local citations. The most productive organization is Wooridul Spine Hospital.
    CONCLUSION: The bibliometric study showed a growing trend of research on full-endoscopic decompression spine surgery over the past 30 years. It has demonstrated that there is a significant increase in the number of authors, institutions, and internationally collaborated countries. However, the quality of studies is still low, and the lack of high-quality clinical evidence and the trend of general journal submissions has somewhat affected the quality of endoscopy journals in recent years.
    Keywords:  CiteSpace; VOSviewer; bibliometric analysis; citation analysis; spine; spine surgery
    DOI:  https://doi.org/10.14245/ns.2245042.521
  8. J Robot Surg. 2023 Apr 05.
      This study aimed to investigate and summarise the current state of research and trends in orthopaedic surgical robots. Data on publicly available publications related to orthopaedic surgical robots were extracted by abstract searches of the Web of Science Core Collection database. A bibliometric analysis and detailed reading of the publications were then carried out and the information was visualised using co-authorship analysis, coupling analysis, co-citation analysis and co-occurrence analysis in VOSviewer. With 436 publications included in the study from 1993 to 2022, the overall contribution of publications to the world showed an increasing trend year by year, with a particularly pronounced after 2017, and a geographical trend of predominantly East Asia, North America, and Western Europe. Of these, China was the largest contributor (n = 128). Overall, the UK affiliates and their scholars were leaders in the field, with a high number of publications, total citations, average citations per article and H-index. The most published institutions and authors were Imperial College London (n = 21) and Professor Fares Sahi Haddad of University College London (n = 12), respectively. Journals with a high overall impact on robotic orthopaedic surgery were the Journal of Arthroplasty, Bone Joint Journal, International Journal of Medical Robotics and Computer Assisted Surgery. Keyword co-occurrence network analysis revealed four main clusters: robot-assisted knee, hip arthroplasty, spine surgery, and robotic technology research and development. The top three most common sites for robot-assisted surgery use were the knee, hip and spine. The most used robot types were the knee and spine, with Mako and Arobot being the most used robots for the knee and TiRobot for the spine. This study comprehensively reveals the current status and trends of global research on orthopaedic surgical robots, covering countries, institutions, authors, journals, research hotspots, robot types and surgical sites, providing directional guidance and research ideas for further research on the technological development and clinical evaluation of orthopaedic surgical robots.
    Keywords:  Bibliometrics; Information visualisation; Orthopaedics; Surgical robot
    DOI:  https://doi.org/10.1007/s11701-023-01579-x
  9. World Neurosurg. 2023 Apr 03. pii: S1878-8750(23)00440-0. [Epub ahead of print]
      To develop a research overview of brain tumour classification using machine learning, systematic review with bibliometric analysis was conducted, which is reported here. This study provides a systematic review based on bibliometric analysis of 1747 publications on automated brain tumor detection using machine learning, published in past 5 years (2019 - 2023) in 679 different sources, authored by 6632 scholars. Bibliographic data was collected from Scopus database and comprehensive bibliometric analysis was conducted using Biblioshiny based on R Platform. The most productive and collaborative institutes, papers, journals and countries were revealed based on citation analysis. Besides, various collaboration metrics were presented on the institute, country and author level. Lotka's law was tested based on the authors performance. Analysis showed that authors publication trends followed Lotka's inverse square law. Annual publication analysis showed that 36.46 percent papers were published in 2022, with an steady growth from previous years. Most cited authors focused on multi class classification along with novel Convolutional Neural Network (CNN) models that are efficient for small training sets. Keywords analysis showed that deep learning, MRI, Nuclear MRI, glioma appeared most times, proving that among several brain tumour types, most studies focused on Glioma. India, China and USA were among the highest collaborative countries both in terms of authors and institutes. University of Toronto, Harvard Medical School had the highest number of affiliations with 132 and 87 publications respectively.
    Keywords:  Brain Tumor Segmentation; Computer Aided Diagnostics; Deep Learning; MRI; Machine Learning
    DOI:  https://doi.org/10.1016/j.wneu.2023.03.115
  10. Environ Sci Pollut Res Int. 2023 Apr 05.
      The maritime sector plays a key role in transportation in the world, and over 90% of world trade is carried by ocean shipping. However, ships are large contributors to global emissions. Hence, a vast majority of research publications have focused on different emission monitoring techniques, which are essential to establishing required policies and regulations that reduce maritime transport emissions. Various documents have been published on monitoring maritime transport emissions affecting air quality since 1977. This paper presents a bibliometric analysis to explore evolution trends, gaps, challenges, and productive countries, as well as the most cited publications with high scholarly impacts. The annual growth of 9.64% in publications demonstrates an increasing interest in reducing maritime vessel emissions. Journal articles constitute 69% of publications, followed by conference papers (25%). China and the USA play a leading role in this field of research. Regarding active resources, the "Atmospheric Environment" journal accounts for the highest relevant publications, H-index, and total citations. Eventually, the temporal evolution of keywords shows the increasing trend towards sustainable maritime transport.
    Keywords:  Bibliometric analysis; Green ships; Maritime monitoring; Ship exhaust emission; Sustainable maritime transport
    DOI:  https://doi.org/10.1007/s11356-023-26723-w
  11. Front Med (Lausanne). 2023 ;10 1031713
      Objective: To identify author collaborations and impact; participating countries, institutions, and journals; evaluate the knowledge base; and analyze research hotspots and frontiers in teaching reforms in physiology.Methods: Articles and reviews related to teaching reforms in physiology published between January 1, 2012, and December 31, 2021, were obtained from the Web of Science Core Collection. Two Scientometric software applications (CiteSpace 5.7 and VOSviewer 1.6.15) were used to perform bibliometric and knowledge-map analysis, generate network maps, and identify research trends and top keywords, authors, co-cited authors, institutions, countries, journals, and references.
    Results: The search identified a total of 2,882 papers in 466 academic journals by 13,895 authors from 4,072 organizations in 67 countries/regions. Physiology teaching reform-related publications increased rapidly over time. Arango-Lasprilla and Rivera published the most papers, while Moseley had the most co-citations. Active collaborations among physiology researchers were noted. Advances in Physiology Education published the most papers on physiology teaching reforms and was also the top co-cited journal in the Medicine/Medical/Clinical, Psychology/Education/Health, and Neurology/Sports/Ophthalmology fields. The United States and University of California published the most physiology teaching publications in the search criteria. Ten references (research articles and reviews) on mechanisms and diseases were identified as the knowledge base. The mainstream research directions were education, Alzheimer's disease, performance, physiology, and risk factors. Mental health and emotion regulation are increasing in significance and may become new hotspots. The research trend to move from the field of pain pathogenesis to the field of neuropsychiatry has become increasingly clear. This tendency away from peripheral system-based disorders to central system-based orders is inextricably linked to further developments in physiological understanding of the brain.
    Conclusion: This study analyzed the research hot spots and frontiers of teaching reforms on in physiology using bibliometric and visual methods. Based on the results, rehabilitation, neurosciences, and infectious disease are hot topics in physiology. In particular, the pathogenesis of neurological diseases, treatment strategies, and technology updates have gradually become research hotspots. We predict that this trend is closely related to the implementation of brain research programs in various countries. These findings provide helpful references for scholars focusing on physiology education.
    Keywords:  bibliometrics; knowledge-map; physiology; teaching reform; visualization
    DOI:  https://doi.org/10.3389/fmed.2023.1031713
  12. Front Pharmacol. 2023 ;14 1076921
      Background: At the end of the 1990s, transient receptor potential vanilloid 1 (TRPV1) was first identified and cloned, serving as a key pain and heat sensor in humans. A large body of evidence have revealed its polymodal structure, complex function and wide-spread distribution, the specific mechanism of the ion channel remains unclear. Our goal here is to perform a bibliometric analysis and visualization study to present hotspots and trends in TRPV1 channel. Materials and Methods: TRPV1-related publications from inception to 2022 were retrieved from the Web of Science database. Excel, VOSviewer, and CiteSpace software were utilized for co-authorship, co-citation and co-occurrence analysis. Results: There were 9,113 publications included in the study, the number of publications increased rapidly after 1989, from 7 in 1990 to 373 in 2007, during which the number of citations per publication (CPP) also reached a peak in 2000 (CPP = 106.52). A total of 1,486 journals published TRPV1 articles, mainly belong to Q1 or Q2 divisions; The United States published the most articles (TP = 3,080), followed by Japan (TP = 1,221), China (TP = 1,217), and England (TP = 734); In recent years, the TRPV1-related research direction has been broaden to multiple fields related to inflammation, oxidative stress, and apoptosis; Keyword clustering refined the topic distributions and could be generalized as neuralgia, endogenous cannabinoid system, TRPV1 mediated airway hyperresponsiveness, involvement of apoptosis, TRPV1 antagonists as therapy targets. Conclusion: By conducting an exhaustive bibliographic search, this review refined the topic distributions and generalized as neuralgia, endogenous cannabinoid system, TRPV1 mediated airway hyperresponsiveness, involvement of apoptosis, TRPV1 antagonists as therapy targets. It is currently being clarified how exactly TRPV1 works as an ion channel, and much more in-depth basic research is needed in the future.
    Keywords:  TRPV1; VOSviewer; bibliometric; citespace; research hotspots
    DOI:  https://doi.org/10.3389/fphar.2023.1076921
  13. Neurol India. 2023 Mar-Apr;71(Supplement):71(Supplement): S39-S48
      There is a plethora of papers on the role of stereotactic radiosurgery (SRS) in various benign and malignant intracranial tumors, and it is possible to overlook the most important and landmark studies. Thus, the necessity of citation analysis arises, which reviews the most cited articles and recognizes the impact made by these articles. Utilizing the 100 most cited articles describing the use of SRS for intracranial and spinal pathologies, this article aims to provide meaningful information regarding the historical trends and recent directions in which this field is headed. We performed a search of the Web of Science database using the keywords "stereotactic radiosurgery," "gamma knife," "GKRS," "gamma knife radiosurgery," "LINAC," and "Cyberknife" on May 14, 2022. Our search retrieved a total of 30,652 articles published between the years 1968 and 2017. The top 100 cited articles were arranged in descending order based on citation count (CC) and citation per year (CY). The journal with the largest number of publications as well as citation count was the International Journal of Radiation Oncology Biology Physics (n = 33), followed by Journal of Neurosurgery (n = 25). The most cited article was authored by Andrews, which was published in 2004 in The Lancet (1699 CC, 89.42 CY). Flickinger, with 25 papers and 7635 total citations, was the author with the highest impact. Lunsford, with 25 publications and total citations of 7615, was a close second. The USA was the leading country with the maximum number of total citations (n = 23,054). Ninety-two articles described the use of SRS for intracranial pathologies (metastases, n = 38; AVM, n = 16; vestibular schwannoma, n = 9; meningioma, n = 8; trigeminal neuralgia, n = 6; sellar lesion, n = 2; glioma, n = 2; functional, n = 1; and procedure related, n = 10). Eight studies describing spinal radiosurgery were included, out of which four were on spinal metastases. Citation analyses of the top 100 articles revealed that the focus of research in the field of SRS started with functional neurosurgery and progressed to benign intracranial tumors and AVMs. More recently, central nervous system (CNS) metastases have received the maximum attention with 38 articles, including 14 randomized controlled trials finding a place in the top 100 cited articles. Presently, the use of SRS is concentrated in developed countries. Efforts need to be made for more widespread use in developing nations to bring the maximum possible benefits of this focused noninvasive treatment to a wider population.
    Keywords:  Bibliometric analysis; Cyberknife; Gamma Knife radiosurgery; LINAC; radiosurgery
    DOI:  https://doi.org/10.4103/0028-3886.373651
  14. J Cardiothorac Surg. 2023 Apr 07. 18(1): 107
      OBJECTIVES: The aim of this bibliometric analysis was twofold: to identify the 100 most cited research articles on thymoma and to highlight future research opportunities in light of past and current research efforts.METHODS: The Web of Science database was queried to identify the 100 most cited articles on thymoma. Imformations relevant to scientific research were extracted and analyzed: first author, journal, impact factor, type of article, year of publication, country, organization and keywords.
    RESULTS: The publication year of the top 100 most cited articles ranged from 1981 to 2018, and the number of citations ranged from 97 to 1182. Most of the included articles are original (75/100) and are mainly retrospective studies (52/75). The United States has the most published articles and citations, and the Annals of Thoracic Surgery is the most sourced journal (n = 16). Through VOSviewer analysis, high-density keywords mainly come from thymic carcinoma/invasive thymoma management, immune-related diseases, and laboratory research.
    CONCLUSIONS: To our knowledge, this is the first bibliometric study on thymoma. We found most of the top 100 most cited articles are original and retrospective research. The United States has the published and cited works. Presently, the hot keywords for thymoma research has gradually tilted towards immune-related diseases and laboratory research.
    Keywords:  Bibliometric analysis; Citations; Thymic carcinoma; Thymoma; Treatment
    DOI:  https://doi.org/10.1186/s13019-023-02201-9
  15. J Vitreoretin Dis. 2021 Nov-Dec;5(6):5(6): 467-478
      Purpose: This work aimed to identify and analyze the most frequently cited articles in retinal detachment (RD).Methods: Institute for Scientific Information's Web of Science index (Thomas Scientific) was used to identify the top 100 most cited articles on RD between 1900 and 2019. Data from the top 100 most cited articles that met inclusion criteria were analyzed based on title, citation frequency, authorship, institution, journal, year of publication, and country of origin.
    Results: The top 100 articles in RD were cited 88 to 480 times. Steven K. Fisher was the most cited individual, with the University of California system being the most cited organization. Sixty-four percent of the top 100 articles originated from the United States and were published in the American Journal of Ophthalmology, Ophthalmology, and Archives of Ophthalmology at frequencies of 36%, 24%, and 11%, respectively. The top funding agencies included the US Department of Health and Human Services, the National Institutes of Health, and the National Eye Institute at 29%, 28%, and 27%, respectively. The top-cited article, which assessed the role of the retinal pigment epithelium by histologic and electron microscopic analysis of RDs in eyes of owl monkeys, was by Machemer and Laqua in the American Journal of Ophthalmology.
    Conclusions: This bibliometric analysis provides researchers and clinicians with a detailed overview of the most cited manuscripts in RD. Such analyses may guide researchers and funding agencies on important research areas in the field.
    Keywords:  bibliometric; most cited; retinal detachment
    DOI:  https://doi.org/10.1177/24741264211007378
  16. Front Microbiol. 2023 ;14 1055804
      Background: An increasing number of studies have focused on the role of gut microbiota in the treatment of ADHD, but its related molecular mechanisms are not yet clear, and there is still room for development of studies targeting this area. This study analyzes publications from 2012 to 2021 in a comprehensive and multi-faceted visualization, with the aim of grasping the existing research profile and guiding scholars to make more in-depth studies.Methods: The 1,677 articles and 298 review articles on gut microbiota in ADHD were retrieved from the Web of Science Core Collection. CiteSpace, VOSviewer, Microsoft Excel 2019, Scimago Graphica, Bibliometrix and Pajek metrics software were used for visualization and analysis of the included literature.
    Results: On August 3, 2022, a total of 1975 English-language articles on gut microbiota in ADHD were retrieved from Web of Science Core Collection (WoSCC) from January 2012 to December 2021, with a steady upward trend in the number of articles published in this field over the decade. The top three countries in terms of the number of articles published are the United States, China, and Spain. Meanwhile, CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS CSIC, UNIV OF CALIFORNIA SYSTEM, and UDICE FRENCH RESEARCH UNIV have made significant contributions in this field. In the analysis of the published journals, PLoS One was not only the first in terms of number of articles published but also the most cited. Wang J was the most prolific author and CAPORASO JG ranked first in terms of co-cited authors. In addition, "Diet rapidly and reproducibly alters the human gut microbiome," published by David LA et al., has the highest citation frequency in this field. The most frequently occurring keyword was "gut microbiota."
    Conclusion: The results of this paper clarify the current status of research on gut microbiota in ADHD. Based on the research on the mechanism of gut microbiota in other diseases, there is reason to believe that the exploration of gut microbiota in ADHD must be increasingly mature. And the study speculates that future research may focus on "nutrition supplements," "lipid metabolism," and "gut brain axis." It is imperative to promote a closer international cooperation among scholars in this field.
    Keywords:  CiteSpace; attention-deficit and hyperactivity disorder; bibliometric analysis; gut microbiota; visualization analysis
    DOI:  https://doi.org/10.3389/fmicb.2023.1055804
  17. Front Public Health. 2023 ;11 1136939
      Background: Acute kidney injury (AKI) is a serious clinical complication associated with adverse short-term and long-term outcomes. In recent years, with the rapid popularization of electronic health records and artificial intelligence machine learning technology, the detection rate and treatment of AKI have been greatly improved. At present, there are many studies in this field, and a large number of articles have been published, but we do not know much about the quality of research production in this field, as well as the focus and trend of current research.Methods: Based on the Web of Science Core Collection, studies reporting machine learning-based AKI research that were published from 2013 to 2022 were retrieved and collected after manual review. VOSviewer and other software were used for bibliometric visualization analysis, including publication trends, geographical distribution characteristics, journal distribution characteristics, author contributions, citations, funding source characteristics, and keyword clustering.
    Results: A total of 336 documents were analyzed. Since 2018, publications and citations have increased dramatically, with the United States (143) and China (101) as the main contributors. Regarding authors, Bihorac, A and Ozrazgat-Baslanti, T from the Kansas City Medical Center have published 10 articles. Regarding institutions, the University of California (18) had the most publications. Approximately 1/3 of the publications were published in Q1 and Q2 journals, of which Scientific Reports (19) was the most prolific journal. Tomašev et al.'s study that was published in 2019 has been widely cited by researchers. The results of cluster analysis of co-occurrence keywords suggest that the construction of AKI prediction model related to critical patients and sepsis patients is the research frontier, and XGBoost algorithm is also popular.
    Conclusion: This study first provides an updated perspective on machine learning-based AKI research, which may be beneficial for subsequent researchers to choose suitable journals and collaborators and may provide a more convenient and in-depth understanding of the research basis, hotspots and frontiers.
    Keywords:  acute kidney injury; bibliometric analysis; critical care; hotspot; machine learning; model
    DOI:  https://doi.org/10.3389/fpubh.2023.1136939
  18. J Orthop. 2023 Apr;38 53-61
      Background: Curative treatment of bone sarcoma is primarily based on operative management. The Orthopedic Oncology approach towards this disease has evolved greatly to the breakthrough in systemic treatment options as well as unique implant designs favoring limb salvage over amputations. The purpose of this study was to perform a bibliometric analysis of the top 50 most cited papers related to the orthopedic the approach to bone sarcomas.Methods: We queried the ISI Web of Knowledge database in July 2022. Keywords utilized were: ""Bone Sarcoma" OR "Osteosarcoma" OR "Ewing Sarcoma" OR "Chondrosarcoma" OR "Chordoma". The top 50 articles pertaining to the orthopedic approach to bone sarcoma were included for analysis and included manuscript title, authors, citation count, journal and publication year.
    Results: The mean number of citations are 187.06 (Range 125-400; SD 67.83). The average citations per year is 10.03 (Range 47.86-3.43; SD 8.05). Many articles were published from 2000 to 2009 (n = 20) and 1990-1999 (n = 13). The majority of the articles were published by institutions within the United States (n = 32). The most common level of evidence was level IV (n = 37). Majority of the articles focused on treatment outcome (n = 22).
    Conclusion: This study offers a comprehensive review of the most cited literature regarding orthopedic approaches to bony sarcomas. Modern treatment approaches for bone sarcoma has resulted in an increased focus within the literature on achieving disease free survival wide tissue margins. Understanding the trends of available studies allows for physicians and researchers to target and innovate future areas of study.
    DOI:  https://doi.org/10.1016/j.jor.2023.03.006
  19. Front Neurosci. 2023 ;17 1128851
      Background: Electroencephalogram (EEG), one of the most commonly used non-invasive neurophysiological examination techniques, advanced rapidly between 2005 and 2022, particularly when it was used for the diagnosis and prognosis of mild cognitive impairment (MCI). This study used a bibliometric approach to synthesize the knowledge structure and cutting-edge hotspots of EEG application in the MCI.Methods: Related publications in the Web of Science Core Collection (WosCC) were retrieved from inception to 30 September 2022. CiteSpace, VOSviewer, and HistCite software were employed to perform bibliographic and visualization analyses.
    Results: Between 2005 and 2022, 2,905 studies related to the application of EEG in MCI were investigated. The United States had the highest number of publications and was at the top of the list of international collaborations. In terms of total number of articles, IRCCS San Raffaele Pisana ranked first among institutions. The Clinical Neurophysiology published the greatest number of articles. The author with the highest citations was Babiloni C. In descending order of frequency, keywords with the highest frequency were "EEG," "mild cognitive impairment," and "Alzheimer's disease".
    Conclusion: The application of EEG in MCI was investigated using bibliographic analysis. The research emphasis has shifted from examining local brain lesions with EEG to neural network mechanisms. The paradigm of big data and intelligent analysis is becoming more relevant in EEG analytical methods. The use of EEG to link MCI to other related neurological disorders, and to evaluate new targets for diagnosis and treatment, has become a new research trend. The above-mentioned findings have implications in the future research on the application of EEG in MCI.
    Keywords:  Alzheimer’s disease; CiteSpace; bibliometrics; electroencephalogram; mild cognitive impairment
    DOI:  https://doi.org/10.3389/fnins.2023.1128851
  20. Front Cell Infect Microbiol. 2023 ;13 1083987
      Background: Increasing evidence has shown that the intestinal microbiome (IM) is highly linked to colorectal cancer (CRC). To investigate scientific output, identify highly cited papers, and explore research hotspots and trends in the field of IM/CRC, we conducted a bibliometric and visualized analysis.Methods: A bibliographic search regarding IM/CRC research (2012-2021) was implemented on October 17, 2022. The terms attached to IM and CRC were searched for in the titles (TI), abstracts (AB), and author keywords (AK). The main information was extracted from the Web of Science Core Collection (WoSCC). Biblioshiny from R packages and VOSviewer were used for data visualization.
    Results: A total of 1725 papers related to IM/CRC were retrieved. Publications on IM/CRC have grown rapidly from 2012 to 2021. China and the United States were in the leading position for publications in this field and made the most significant contributions to IM/CRC research. Shanghai Jiao Tong University and Harvard University were the most productive institutions. The high-yield authors were Yu Jun and Fang Jing Yuan. The International Journal of Molecular Sciences published the most papers, whereas Gut had the most citations. Historical citation analysis showed the evolution of IM/CRC research. Current status and hotspots were highlighted using keyword cluster analysis. The hot topics include the effect of IM on tumorigenesis, the effect of IM on CRC treatment, the role of IM in CRC screening, the mechanisms of IM involvement in CRC, and IM modulation for CRC management. Some topics, such as chemotherapy, immunotherapy, Fusobacterium nucleatum and short-chain fatty acids could be the focus of IM/CRC research in the coming years.
    Conclusion: This research evaluated the global scientific output of IM/CRC research and its quantitative features, identified some significant papers, and gathered information on the status and trends of IM/CRC research, which may shape future paths for academics and practitioners.
    Keywords:  bibliometrics; colorectal cancer; high-cited papers; hotspots and trends; intestinal microbiome
    DOI:  https://doi.org/10.3389/fcimb.2023.1083987
  21. Ann Vasc Surg. 2023 Apr 03. pii: S0890-5096(23)00192-9. [Epub ahead of print]
      BACKGROUND: Dedicated studies on patient outcomes are crucial to the development of effective policies aimed at prevention and management of vascular diseases. This study aims to determine the scientific productivity of Latin American countries through a bibliometric analysis of top 5 vascular journals.METHODS: The five dedicated vascular journals indexed in the "surgery" category were selected for analysis. These were the European Journal of Vascular and Endovascular Surgery (EJVES), the Journal of Vascular Surgery (JVS), the Journal of Endovascular Therapy (JEVT), the Journal of Vascular Surgery: Venous and Lymphatic Diseases (JVS-VL) and the Annals of Vascular Surgery (AVS). Databases were queried with the combination of each journal's name + each of the 21 Latin American countries. All possible combinations were searched. Inclusion criteria were articles affiliated with a university, medical center, or hospital from any Latin American country.
    RESULTS: A total of 501 articles were retrieved, 104 (20.7%) were published between 2000 and 2011, and 397 (79.2%) between 2012 and 2022. The journal with the most publications was AVS with 221 (43.9%), followed by JVS with 135 (26.9%), EJVES with 60 (11.9%), JEVT with 49 (9.9%), and JVS-VL with 36 (7.1%). Brazil had the highest volume of publications, with 346 (69.0%) followed by Argentina with 54 (10.7%), Chile with 35 (6.9%), and Mexico with 32 (6.3%). JVS had a higher median citation when compared with the AVS, JVS-VL, and JEVT, 18 vs. 5, 5.5, and 7, respectively (p=<0.001). Furthermore, JVS had a greater median citation than EJVES, at 18 vs. 12.5, respectively (p=0.005). Median citation per year from 2000-2011 was 1.59 (range: 0-45), and 1.50 (range: 0-114.5) from 2012-2022 (p=0.02).
    CONCLUSION: Latin America's research output within the vascular surgery field has increased over the years. Efforts must be made to increase research output in this region and translate findings into effective interventions for these populations.
    Keywords:  Latin America; bibliometric analysis; research output; vascular; vascular surgery
    DOI:  https://doi.org/10.1016/j.avsg.2023.03.024
  22. J Dent Sci. 2023 Apr;18(2): 872-882
      Background/purpose: Head and neck squamous cell carcinoma (HNSCC) is a serious disease endangering the health of patients, and the application of immunotherapy in HNSCC is gradually emerging. However, there is no bibliometric analysis in this research field. This study aims to provide a comprehensive overview of the knowledge structure and research hotspots of immunotherapy for HNSCC.Materials and methods: Publications related to immunotherapy for HNSCC from 2002 to 2021 were searched in the Web of Science Core Collection database. The software VOSviewers, CiteSpace, and the R package 'bibliometrix' were used to perform this bibliometric analysis.
    Results: A total of 1297 publications were from 63 countries, led by the USA and China. The number of publications related to immunotherapy for HNSCC has increased rapidly from 2015. University of Pittsburgh and The University of Texas M.D. Anderson Cancer Center are the main research institutions. Oral Oncology is the most popular journal in this field, and the Journal of Clinical Oncology is the most highly co-cited journal. These publications were from 7569 authors, with Robert L. Ferris publishing the most papers and being the most frequently co-cited. Clinical trials related to nivolumab and pembrolizumab have attracted wide attention. 'Immune checkpoint inhibitors', 'human papillomavirus', 'programmed cell death-ligand 1', and 'programmed cell death protein 1' are the main keywords of emerging research hotspots.
    Conclusion: This study presents a comprehensive summary of the trends and development of immunotherapy for HNSCC, identifies the research frontier and hotspot direction, and could provide a valuable reference for researchers in this field.
    Keywords:  Bibliometric; Head and neck squamous cell carcinoma; Immune checkpoint inhibitors; Immunotherapy; Programmed cell death-ligand 1
    DOI:  https://doi.org/10.1016/j.jds.2023.02.007
  23. Front Public Health. 2023 ;11 1119117
      Background: Scientific activity has been connected to the proven inequality between women and men. To examine the state of gender equality in nursing research by analyzing the representation of male and female as editors and as authors of articles published in scientific journals.Method: A cross-sectional study was carried out between September-2019 and May-2020. All the scientific publications published in 115 nursing journals indexed in the Journal Citation Reports in the years 2008, 2013, and 2017 were chosen as analysis units. The main variables studied were gender of the "journal editor"; gender of the "first author", "last author", "corresponding author", and "first author in funded articles". Descriptive and inferential analysis was performed.
    Results: The proportion of male editors in 2008, 2013, and 2017 was 23.3, 19, and 18.5% respectively, with a male/female ratio of 1:3, 1:4 and 1:5. Male editors are mainly found in the journals of the first quartile (Q1 = 33.8%, ratio1:2), compared to the journals of the fourth quartile (Q4 = 6.6%, ratio1:14), p < 0.01. The male authorship position was "last author" (30.9%, ratio1:2), "corresponding author" (23.3%, ratio 1:3), "first author" (22.1%, ratio 1:4) and "first author in funded articles" (21.8%, ratio 1:4). Furthermore, in 19.5%, of the articles there were more male authors. The percentage of articles with male authorship increased from 2008 to 2017, "first author" (21.1-23.4%; p < 0.01), "last author" (30.0-31.1%; p = 0.22), "corresponding author" (22.5-24.2; p = 0.01), and "first author in funded articles" (18.1-25.9%; p < 0.001).
    Conclusions: Men are over-represented in the editor role in the most prestigious nursing journals. There are a higher proportion of male authors in the main positions of authorship.
    Keywords:  cross-sectional studies; gender equity; journal article; journal impact factor; nursing
    DOI:  https://doi.org/10.3389/fpubh.2023.1119117
  24. Front Plant Sci. 2023 ;14 1084355
      Aims: Drought stress is one of the most limiting factors for agriculture and ecosystem productivity. Climate change exacerbates this threat by inducing increasingly intense and frequent drought events. Root plasticity during both drought and post-drought recovery is regarded as fundamental to understanding plant climate resilience and maximizing production. We mapped the different research areas and trends that focus on the role of roots in plant response to drought and rewatering and asked if important topics were overlooked.Methods: We performed a comprehensive bibliometric analysis based on journal articles indexed in the Web of Science platform from 1900-2022. We evaluated a) research areas and temporal evolution of keyword frequencies, b) temporal evolution and scientific mapping of the outputs over time, c) trends in the research topics analysis, d) marked journals and citation analysis, and e) competitive countries and dominant institutions to understand the temporal trends of root plasticity during both drought and recovery in the past 120 years.
    Results: Plant physiological factors, especially in the aboveground part (such as "photosynthesis", "gas-exchange", "abscisic-acid") in model plants Arabidopsis, crops such as wheat and maize, and trees were found to be the most popular study areas; they were also combined with other abiotic factors such as salinity, nitrogen, and climate change, while dynamic root growth and root system architecture responses received less attention. Co-occurrence network analysis showed that three clusters were classified for the keywords including 1) photosynthesis response; 2) physiological traits tolerance (e.g. abscisic acid); 3) root hydraulic transport. Thematically, themes evolved from classical agricultural and ecological research via molecular physiology to root plasticity during drought and recovery. The most productive (number of publications) and cited countries and institutions were situated on drylands in the USA, China, and Australia. In the past decades, scientists approached the topic mostly from a soil-plant hydraulic perspective and strongly focused on aboveground physiological regulation, whereas the actual belowground processes seemed to have been the elephant in the room. There is a strong need for better investigation into root and rhizosphere traits during drought and recovery using novel root phenotyping methods and mathematical modeling.
    Keywords:  bibliometric analysis (BA); intermittent drought; nutrient homeostasis; recovery; root dynamics
    DOI:  https://doi.org/10.3389/fpls.2023.1084355
  25. Enferm Infecc Microbiol Clin (Engl Ed). 2023 Apr 05. pii: S2529-993X(23)00092-8. [Epub ahead of print]
      INTRODUCTION: The profound impact of the Covid-19 pandemic, together with other factors such as globalisation and climate change, has emphasised the growing relevance of Infectious Diseases and Microbiology.METHODS: The Spanish scientific production in both categories of the Web of Science databases over the period 2014-2021 has been analysed.
    RESULTS: 8037 documents have been identified in Infectious Diseases and 12008 documents in Microbiology (6th most productive country worldwide in both cases, with growth rates of 41% and 46.2%, respectively). Both areas present a high degree of international collaboration (45-48% of the documents) and between 45-66% of the documents have been published in journals of excellence (first quartile) according to the rankings of the Journal Citation Reports.
    CONCLUSIONS: Spain is in a prominent position worldwide in both areas, with an outstanding scientific production in journals of high visibility and impact.
    Keywords:  Bibliometric study; Enfermedades infecciosas; España; Estudio bibliométrico; Infectious diseases; Microbiology; Microbiología; Producción científica; Scientific production; Spain
    DOI:  https://doi.org/10.1016/j.eimce.2023.03.005
  26. Dental Press J Orthod. 2023 ;pii: S2176-94512023000100301. [Epub ahead of print]28(1): e2321175
      INTRODUCTION: The number of published orthodontic studies has increased considerably over the past ten years.OBJECTIVE: To analyze the bibliometric data of international orthodontic studies included in orthodontic journals encompassed by the Scopus database between 2011 and 2020, as well as to undertake data comparison between the period 2010-2015 and the period 2016-2020.
    MATERIALS AND METHODS: A retrospective search was conducted on 14 orthodontic journals included in the Scopus database from 2011 to 2020. Studies of both primary and secondary types were targeted by the search. The yearly number of studies published in the 14 journals, and the first 20 countries, institutions and their type (public/private), and authors, respectively, regarding publication volume, were presented.
    RESULTS: Over the past ten years, the number of publications in the chosen journals reached 9200, where the American Journal of Orthodontics and Dentofacial Orthopedics and Angle Orthodontist topped the journal list, with 22% and 12% of the publications, respectively. Furthermore, the orthodontic publication volume showed a declining trend by the end of the decade (-9%), where academic/public institutions produced most of the orthodontic studies, and the US (20%), Brazil (17%), and South Korea (8%) topped the countries with the most orthodontic studies. A comparison of the two halves of the decade revealed that orthodontic research exhibited an increasing trend in developing nations, especially Egypt (104%), Saudi Arabia (88%), and Iran (83%).
    CONCLUSION: The orthodontic studies published in the chosen journals over the past ten years showed a dynamic change in yearly publication and ranking of countries, institutions, and authors.
    DOI:  https://doi.org/10.1590/2177-6709.28.1.e2321175.oar
  27. Ann Transl Med. 2023 Mar 15. 11(5): 219
      Background: The literature on artificial intelligence (AI)-related topics has been expanding rapidly over the last two decades, showing that AI is a crucial force in advancing ophthalmology. This analysis aims to provide a dynamic and longitudinal bibliometric analysis of AI-related ophthalmic papers.Methods: The Web of Science was searched to retrieve papers regarding the application of AI in ophthalmology published in the English language up to May 2022. The variables were analyzed using Microsoft Excel 2019 and GraphPad Prism 9. Data visualization was performed using VOSviewer and CiteSpace.
    Results: In this study, a total of 1,686 publications were analyzed. Recently, AI-related ophthalmology research has increased exponentially. China was the most productive country in this research field, with 483 articles, but the United States of America (446 publications) contributed most to the sum of citations and the H-index. The League of European Research Universities, Ting DSW, and Daniel SW were the most prolific institution and researchers. This field is primarily concerned with diabetic retinopathy (DR), glaucoma, optical coherence tomography, and the classification and diagnosis of fundus pictures. Current hotspots in AI research include deep learning, diagnosing and predicting systemic disorders by fundus images, incidence and progression of ocular diseases, and outcome prediction.
    Conclusions: This analysis thoroughly reviews AI-related research in ophthalmology to help academics better comprehend the growth and possible practice consequences of AI. The association between eye and systemic biomarkers, telemedicine, real-world studies, and the development and application of new AI algorithms, such as visual converters, will continue to be research hotspots over the next few years.
    Keywords:  Artificial intelligence (AI); VOSviewer; bibliometrics; data visualization; ophthalmology
    DOI:  https://doi.org/10.21037/atm-22-3773
  28. Hum Vaccin Immunother. 2023 Apr 05. 2186684
      Gastric cancer (GC) is one of the most common malignancies. Immunotherapy becomes an indispensable part of GC. This study conducts bibliometric analysis of immunotherapy for GC to clarify the research status and identify potential new research directions. VOS viewer and CiteSpace visualization software were used to demonstrate collaborations and correlations. A total of 1141 English publications from 2012 to 2022 were included. The number of publications increased year by year. The publications were mainly from China (n = 579, 50.70%), followed by the United States. Fudan University published the most publications (n = 48, 4.21%). Frontiers in Oncology and Journal of Clinical Oncology ranked first in cited and co-cited journals, respectively. Kim Kyoung-Mee published the most publications on immunotherapy for GC (n = 14). The clustering of timeline view and co-cited references show the hotspot transformation on immunotherapy for GC. Initially, the hot topic was "cytokine-induced killer cells" and "myeloid-derived suppressor cells." In recent years, the focus has turned to "targeted therapy." "CAR-T" has become the hottest topic, and GC has entered precision therapy phase. Screening patients who can benefit from immunotherapy is key to improving prognosis. The combination of immunotherapy with other treatment options, such as chemotherapy and targeted therapy, is currently the focus of research. Chimeric antigen receptor T cell will be further studied in the future.
    Keywords:  Gastric cancer; VOS viewer; bibliometric analysis; chimeric antigen receptor T cell; citeSpace; immunotherapy; targeted therapy
    DOI:  https://doi.org/10.1080/21645515.2023.2186684
  29. Front Oncol. 2023 ;13 1082423
      Background: Machine learning is now well-developed in non-small cell lung cancer (NSCLC) radiotherapy. But the research trend and hotspots are still unclear. To investigate the progress in machine learning in radiotherapy NSCLC, we performed a bibliometric analysis of associated research and discuss the current research hotspots and potential hot areas in the future.Methods: The involved researches were obtained from the Web of Science Core Collection database (WoSCC). We used R-studio software, the Bibliometrix package and VOSviewer (Version 1.6.18) software to perform bibliometric analysis.
    Results: We found 197 publications about machine learning in radiotherapy for NSCLC in the WoSCC, and the journal Medical Physics contributed the most articles. The University of Texas MD Anderson Cancer Center was the most frequent publishing institution, and the United States contributed most of the publications. In our bibliometric analysis, "radiomics" was the most frequent keyword, and we found that machine learning is mainly applied to analyze medical images in the radiotherapy of NSCLC.
    Conclusion: The research we identified about machine learning in NSCLC radiotherapy was mainly related to the radiotherapy planning of NSCLC and the prediction of treatment effects and adverse events in NSCLC patients who were under radiotherapy. Our research has added new insights into machine learning in NSCLC radiotherapy and could help researchers better identify hot research areas in the future.
    Keywords:  bibliometric analysis; computer science; machine learning; non-small cell lung cancer; radiotherapy
    DOI:  https://doi.org/10.3389/fonc.2023.1082423
  30. Glob Health Res Policy. 2023 Apr 06. 8(1): 10
      BACKGROUND: There has been considerable progress in developing global health education and research in China. Nevertheless, evidence of the progress of Chinese universities' contributions to global health research is limited. More efforts are needed to depict the progress Chinese universities have collectively made in advancing the field of global health. This study aimed to examine Chinese universities' collective contributions to global health research by describing the longitudinal trends in global health research publications, uncovering research themes in global health, and exploring collaboration patterns.METHODS: A comprehensive bibliometric analysis was conducted for original research studies of the ten founding members of the China Consortium of Universities for Global Health, one of the largest networks of global health research and education in China.
    RESULTS: We found that (1) the number of research publications in the field of global health has steadily increased from 2014 to 2020, (2) non-communicable disease was the most popular research topic, accounting for over one-third of total publications, followed by maternal and child health and neurological and mental disorders and diseases, (3) less than one-fifth of papers involved primary data collection, with the majority of the study populations from low-income and lower-middle-income countries in Asia and Africa, and (4) a sizable collaboration network has been established with co-authors from over 200 oversea universities or organizations, with about one third from the US.
    CONCLUSIONS: Despite a variety of challenges and barriers, Chinese universities have been playing an increasingly important role in global health research as assessed by peer-reviewed publications over the last decade. More concerted efforts by multiple stakeholders, including government, private sectors, funding agencies, academic institutions, and researchers, are needed to advance the development of global health research in China.
    Keywords:  China; Global health; Health governance; Maternal and child health; Non-communicable disease
    DOI:  https://doi.org/10.1186/s41256-023-00295-1
  31. Glob Chall. 2023 Apr;7(4): 2200206
      Cell membrane encapsulation is a growing concept in nanomedicine, for it achieves the purpose of camouflage nanoparticles, realizing the convenience for drug delivery, bio-imaging, and detoxification. Cell membranes are constructed by bilayer lipid phospholipid layers, which have unique properties in cellular uptake mechanism, targeting ability, immunomodulation, and regeneration. Current medical applications of cell membranes include cancers, inflammations, regenerations, and so on. In this article, a general bibliometric overview is conducted of cell membrane-coated nanoparticles covering 11 years of evolution in order to provide researchers in the field with a comprehensive view of the relevant achievements and trends. The authors analyze the data from Web of Science Core Collection database, and extract the annual publications and citations, most productive countries/regions, most influential scholars, the collaborations of journals and institutions. The authors also divided cell membranes into several subgroups to further understand the application of different cell membranes in medical scenarios. This study summarizes the current research overview in cell membrane-coated nanoparticles and intuitively provides a direction for future research.
    Keywords:  bibliometrics; cell membrane encapsulation; medical applications; nanoparticles
    DOI:  https://doi.org/10.1002/gch2.202200206
  32. BMJ Glob Health. 2023 Apr;pii: e011514. [Epub ahead of print]8(4):
      BACKGROUND: COVID-19 has affected research productivity across all areas of knowledge. Current evidence suggests that COVID-19 has had a blockbuster effect on journal impact factors (JIFs) and publication trends, while little is known on global health journals.METHODS: Twenty global health journals were included to analyse the impact of COVID-19 on their JIFs and publication trends. Indicator data, including numbers of publications, citations, articles with different types, etc, were extracted from journal websites and Web of Science Core Collection database. The JIFs from 2019 to 2021 were simulated for longitudinal and cross-sectional analyses. Interrupted time-series analysis and non-parametric tests were applied to assess whether COVID-19 had decreased non-COVID-19 publications from January 2018 to June 2022.
    RESULTS: In 2020, 615 out of 3223 publications were COVID-19 related, accounting for 19.08%. The simulated JIFs of 17 out of 20 journals in 2021 were higher than those in 2019 and 2020. Notably, 18 out of 20 journals had a decrease in their simulated JIFs after excluding COVID-19-related publications. Moreover, 10 out of 20 journals decreased their monthly numbers of non-COVID-19 publications after the COVID-19 outbreak. For all the 20 journals as a whole, after the COVID-19 outbreak in February 2020, the total number of non-COVID-19 publications significantly decreased by 14.2 compared with the previous month (p=0.013), and since then, on average, the publications had decreased by 0.6 per month until June 2022 (p<0.001).
    CONCLUSIONS: COVID-19 has impacted the structure of COVID-19-related publications, the JIFs of global health journals and their numbers of non-COVID-19 publications. Although journals may benefit from increased JIFs, global health journals should avoid relying on a single metric. More follow-up studies including more years of data with a combination of metrics should be conducted to generate more robust evidence.
    Keywords:  COVID-19; Cross-sectional survey; Public Health
    DOI:  https://doi.org/10.1136/bmjgh-2022-011514
  33. Death Stud. 2023 Apr 05. 1-14
      Prolonged Grief Disorder (PGD) has become a subject of increased interest among both researchers and practitioners, owing both to its recent inclusion in the DSM-5-TR and the growing evidence of widespread complications of bereavement in the context of the COVID-19 pandemic. From a set of 467 studies obtained from the Scopus database during the period 2009 to 2022, the present research provides bibliographic data on the most influential authors on the subject, most relevant journals based on the number of documents published, a keyword analysis of the focus of this work, and an overall characterization of the scientific literature on PGD. The Biblioshiny application along with VOSviewer software was used for the analysis and visual depiction of the results. Both the scientific and applied implications of this analysis are discussed.
    DOI:  https://doi.org/10.1080/07481187.2023.2196734
  34. Zhongguo Zhong Yao Za Zhi. 2023 Mar;48(6): 1664-1672
      In this study, the Web of Science and China National Knowledge Infrastructure(CNKI) were searched comprehensively for the literature about the research on Polygalae Radix. After manual screening, 1 207 Chinese articles and 263 English articles were included in this study. Excel was used to draw the line chart of the annual number of relevant publications. CiteSpace 6.1.R3 was used for the visual analysis of author cooperation, publishing institutions, keyword co-occurrence, keyword clustering, and bursts in the research on Polygalae Radix. The results showed that the number of articles published in Chinese and English increased linearly, which indicated the rising research popularity of Polygalae Radix. WANG J and LIU X were the authors publishing the most articles in Chinese and English, respectively. Shanxi University of Chinese Medicine and Chinese Academy of Medical Sciences were the research institutions with the largest number of Chinese and English publications in this field, respectively. The institutions publishing the relevant articles in English formed a system with the Chinese Academy of Medical Sciences as the core. According to the keywords, the research hotspots of Polygalae Radix included variety selection and breeding, quality standard, extraction and identification of active chemical components, prescription compatibility, processing, clinical medication rules, and pharmacological mechanism. The research frontiers were the molecular mechanisms of Polygalae Radix and its active components in exerting the protective effect on brain nerve, regulating receptor pathways, alleviating anxiety and Alzheimer's disease, as well as data mining and clinical medication summary. This study has reference significance for the topic selection and frontier identification of the future research on Polygalae Radix.
    Keywords:  CiteSpace; Polygalae Radix; analysis of frontiers; knowledge map; research hotpots
    DOI:  https://doi.org/10.19540/j.cnki.cjcmm.20221129.501
  35. Zhongguo Zhong Yao Za Zhi. 2023 Mar;48(6): 1673-1681
      This study employed bibliometrics tools to review the studies of traditional Chinese medicine(TCM) treatment of Alzheimer's disease(AD) in recent ten years, aiming to explore the research status, hotspots, and future trends in this field at home and abroad. The relevant literature published from January 1, 2012 to August 15, 2022 was retrieved from Web of Science and CNKI. CiteSpace 6.1R2 and VOSviewer 1.6.15 were used for the visual analysis of authors, countries, institutions, keywords, journals, etc. A total of 2 254 Chinese articles and 545 English articles were included. The annual number of articles published showed a rising trend with fluctuations. The country with the largest number of relevant articles published and the largest centrality was China. SUN Guo-jie and WANG Qi were the authors publishing the most Chinese articles and English articles, respectively. Hubei University of Chinese Medicine and Beijing University of Chinese Medicine published the most articles in Chinese and English, respectively. Journal of Ethnopharmacology and Neuroscience Letters published the articles with the highest cited frequency and the highest centrality. According to the keywords, the research on TCM treatment of AD mainly focused on the mechanism of action and treatment methods. Metabolomics, intestinal flora, oxidative stress, tau hyperphosphorylation, β-amyloid(Aβ), inflammatory cytokines, and autophagy were the focuses of the research on mechanism of action. Acupuncture, clinical effect, kidney deficiency and phlegm stasis, and dredging governor vessel to revitalize mind were the hotspots of clinical research. This research field is still in the stage of exploration and development. Exchanges and cooperation among institutions should be encouraged to carry out more high-quality basic research on TCM treatment of AD, obtain high-level evidence, and clarify the pathogenesis and prescription mechanism.
    Keywords:  Alzheimer′s disease; CiteSpace; VOSviewer; bibliometrics; traditional Chinese medicine; visual analysis
    DOI:  https://doi.org/10.19540/j.cnki.cjcmm.20221206.501
  36. Eur J Orthop Surg Traumatol. 2023 Apr 04.
      PURPOSE: Clavicle fractures are among the most common orthopedic fractures, and treatment methods, operative versus nonoperative, have been a point of contention. The purpose of this study was to evaluate the 50 most influential articles regarding clavicle fractures to better understand past focuses of research and to identify any gaps in knowledge.METHODS: A review of the most cited articles related to clavicle fractures was conducted using Web of Science database. A search was conducted in April 2022 by one trained researcher. Two independent researchers evaluated each article based on relevance to clavicle fracture.
    RESULTS: The mean number of citations was 179.1, ranging from 576 to 81 citations, and collectively cited 8954 times. The decade from 2000 to 2009 contributed the greatest portion of articles, with only a small portion coming from before 1980. The Journal of Bone and Joint Surgery-American Volume contributed the greatest number of articles (20%). The majority of the articles were therapeutic (n = 37) and focused on treatment and outcome (n = 32). Most of the clinically focused articles had a level of evidence of IV (n = 26).
    CONCLUSION: There is an increased influence of recent articles focused on clavicle fracture and management, due to the idea that conventional nonoperative treatment has a high rate of nonunion. Many of the most influential studies evaluate the outcomes of various treatments. Many of these studies, however, are lower levels of evidence, leaving a paucity of high level of evidence articles to support these conclusions.
    LEVEL OF EVIDENCE: V.
    Keywords:  Clavicle; Clavicle fracture; Most cited articles; Top 50 influential
    DOI:  https://doi.org/10.1007/s00590-023-03541-x
  37. Account Res. 2023 Apr 06. 1-24
      The sudden spread of the monkeypox virus has been accompanied by an increase in the scientific interest in the virus. More than 1,400 PubMed-indexed documents have been authored by about 5,800 unique authors, averaging around 120 publications per month. This sheer rise in the number led us to explore the content published in the literature. We discovered more than 30% of the documents are Quantitative Productivity (QP) i.e., papers that illustrate the emerging trends of parachute concerns, modified salami tactics, cyclic recycling, and excellence in redundancy. In addition, we found few common hyper-prolific authors previously identified in the COVID-19 literature. Further, we share our experience in publishing monkeypox literature and highlight the growing readership and citation interest in editorials, commentaries, and correspondences that were thought to be uncitable in the medical literature. As long as the scientific community and public demand, the supply of such papers will continue, with no responsibility on the authors, journals, or the reader. Since overhauling the current system is an arduous task, we propose the optimization of existing retrieval services that would selectively filter documents based on article type (requires standardization of definitions) to dilute the crowding out effects of quantitative productivity.
    Keywords:  Bibliometrics; citations; literature; monkeypox; references
    DOI:  https://doi.org/10.1080/08989621.2023.2199159
  38. Zhongguo Zhong Yao Za Zhi. 2023 Mar;48(5): 1370-1380
      We employed bibliometrics to comprehensively study the hotspots and frontiers of gut microbiota research involving traditional Chinese medicine(TCM), aiming to provide new ideas for the subsequent research in this field. The studies of gut microbiota with TCM published from January 1, 2002 to December 31, 2021 were retrieved from CNKI, Wanfang, VIP and Web of Science(WoS). After data screening and cleaning, CiteSpace 5.8.R3 was used to visualize and analyze the authors, journals, and keywords. A total of 1 119 Chinese articles and 815 English articles were included in the study. The period of 2019-2021 witnessed the surge in the number of articles published in this field, being the peak research period. TAN Zhou-jin and DUAN Jin-ao were the authors publishing the most articles in Chinese and English, respectively. The two authors ranked top in both Chinese and English articles, playing a central role in this research field. The top five Chinese and English journals in this field had a large influence in the international research field. High-frequency keywords and keyword clustering showed that the research hotspots in this field were concentrated in four areas: trial and clinical research on the regulation of gut microbiota in disease treatment by TCM, metabolic transformation of Chinese medicines by gut microbiota, and the effect of TCM added to feed on the gut microbiota and growth performance of animals. The study of gut microbiota structure in patients with different TCM syndromes, as well as that of TCM combined with probiotics/flora transplantation in the treatment of diseases, can provide new ideas for clinical diagnosis and traditional drug treatment of diseases and has great research space and research value in the future.
    Keywords:  CiteSpace; bibliometrics; gut microbiota; knowledge map; traditional Chinese medicine
    DOI:  https://doi.org/10.19540/j.cnki.cjcmm.20221026.501
  39. BMC Med Educ. 2023 Apr 01. 23(1): 203
      BACKGROUND: This study aims to identify the characteristics and future directions of online medical education in the context of the novel coronavirus outbreak new through visual analytics using CiteSpace and VOSviewer bibliometric methods.METHOD: From Web of Science, we searched for articles published between 2020 and 2022 using the terms online education, medical education and COVID-19, ended up with 2555 eligible papers, and the articles published between 2010 and 2019 using the terms online education, medical education and COVID-19, and we ended up with 4313 eligible papers.
    RESULTS: Before the COVID-19 outbreak, Medical students and care were the most frequent keywords and the most cited author was BRENT THOMA with 18 times. The United States is the country with the greatest involvement and research impact in the field of online medical education. The most cited journal is ACAD MED with 1326 citations. After the COVID-19 outbreak, a surge in the number of research results in related fields, and ANXIETY and four secondary keywords were identified. In addition, the concentration of authors of these publications in the USA and China is a strong indication that local epidemics and communication technologies have influenced the development of online medical education research. Regarding the centrality of research institutions, the most influential co-author network is Harvard Medical School in the United States; and regarding the centrality of references, the most representative journal to which it belongs is VACCINE.
    CONCLUSION: This study found that hey information such as keywords, major institutions and authors, and countries differ in the papers before and after the COVID-19 outbreak. The novel coronavirus outbreak had a significant impact on the online education aspect. For non-medical and medical students, the pandemic has led to home isolation, making it difficult to offer face-to-face classes such as laboratory operations. Students have lost urgency and control over the specifics of face-to-face instruction, which has reduced the quality of teaching. Therefore, we should improve our education model according to the actual situation to ensure the quality of teaching while taking into account the physical and psychological health of students.
    Keywords:  COVID-19; Co-word analyse; Knowledge spectrum; Medical education; Online education; Visual analysis
    DOI:  https://doi.org/10.1186/s12909-023-04193-5
  40. Zhongguo Zhong Yao Za Zhi. 2023 Mar;48(5): 1381-1392
      Angong Niuhuang Pills, a classical formula in traditional Chinese medicine, are lauded as one of the &quot;three treasures of febrile diseases&quot; and have been widely used in the treatment of diverse disorders with definite efficacy. However, there is still a lack of bibliometric analysis of research progress and development trend regarding Angong Niuhuang Pills. Research articles on Angong Niuhuang Pills in China and abroad(2000-2022) were retrieved from CNKI and Web of Science. CiteSpace 6.1 was used to visualize the key contents of the research articles. In addition, the research status of Angong Niuhuang Pills was analyzed by information extraction to allow insight into the research trends and hotspots about Angong Niuhuang Pills. A total of 460 Chinese articles and 41 English articles were included. Beijing University of Chinese Medicine and Sun Yat-Sen University were the research institutions that have published the largest amount of research articles in Chinese and English. The keyword analysis showed that the Chinese articles focused on cerebral hemorrhage, stroke, neurological function, coma, cerebral infarction, craniocerebral injury, and clinical application, while the English articles focused on the mechanisms of cerebral ischemia, stroke, heavy metal, blood-brain barrier, and oxidative stress. Stroke, blood-brain barrier, and oxidative stress were presumably the research hotspots in the future. At present, the research on Angong Niuhuang Pills is still in the developing stage. It is necessary to highlight the in-depth research on the active components and mechanism of action and carry out large-scale randomized controlled clinical trials to provide references for the further development and application of Angong Niuhuang Pills.
    Keywords:  Angong Niuhuang Pills; CiteSpace; bibliometrics; research status
    DOI:  https://doi.org/10.19540/j.cnki.cjcmm.20221025.501
  41. Front Microbiol. 2023 ;14 1099132
      Background: As an effective strategy that reduces transmission among people at high risk of human immunodeficiency virus (HIV), pre-exposure prophylaxis (PrEP) has revolutionized HIV prevention. Our study aims to provide a reference for the development of relevant research and the formulation of prevention and control policies for HIV.Methods: Through CiteSpace software, this study aims to present a comprehensive overview of the HIV PrEP knowledge structure, hotspots, and frontiers. We searched the Web of Science Core Collection for studies published between 2012 and 2022 related to HIV PrEP, and 3,243 papers remained after selection.
    Results: The number of HIV PrEP publications has increased over the past few years. A close integration and exchange of HIV PrEP research findings has taken place between countries and authors. Major ongoing research trends include long-term injection PrEP, the impact of chlamydia on HIV PrEP, and individual awareness of and attitudes toward HIV PrEP. Thus, more attention should be paid to innovations and breakthroughs in drugs, the factors that affect HIV transmission and susceptibility, and the future promotion of public acceptance of HIV PrEP.
    Conclusion: This study offers a systematic, objective, and comprehensive analysis of the related articles. It will assist scholars in understanding the dynamic evolution of HIV PrEP research and identifying future research areas to better advance the development of the field.
    Keywords:  CiteSpace; HIV/AIDS; emerging trends; pre-exposure prophylaxis; visualization analysis
    DOI:  https://doi.org/10.3389/fmicb.2023.1099132
  42. Front Microbiol. 2023 ;14 1081271
      Helicobacter pylori is a prominent cause of gastritis, peptic ulcer, and gastric cancer. It is naturally colonized on the surface of the mucus layer and mucosal epithelial cells of the gastric sinus, surrounded not only by mucus layer with high viscosity that prevents the contact of drug molecules with bacteria but also by multitudinous gastric acid and pepsin, inactivating the antibacterial drug. With high-performance biocompatibility and biological specificity, biomaterials emerge as promising prospects closely associated with H. pylori eradication recently. Aiming to thoroughly summarize the progressing research in this field, we have screened 101 publications from the web of science database and then a bibliometric investigation was performed on the research trends of the application of biomaterials in eradicating H. pylori over the last decade utilizing VOSviewer and CiteSpace to establish the relationship between the publications, countries, institutions, authors, and most relevant topics. Keyword analysis illustrates biomaterials including nanoparticles (NPs), metallic materials, liposomes, and polymers are employed most frequently. Depending on their constituent materials and characterized structures, biomaterials exhibit diverse prospects in eradicating H. pylori regarding extending drug delivery time, avoiding drug inactivation, target response, and addressing drug resistance. Furthermore, we overviewed the challenges and forthcoming research perspective of high-performance biomaterials in H. pylori eradication based on recent studies.
    Keywords:  Helicobacter pylori; biomaterials; drug delivery; drug resistance; eradication; nanoparticles
    DOI:  https://doi.org/10.3389/fmicb.2023.1081271
  43. Ann Emerg Med. 2023 Apr 05. pii: S0196-0644(23)00127-0. [Epub ahead of print]
      STUDY OBJECTIVE: Since its publication in 2001, the National EMS Research Agenda has brought attention to a relative paucity of emergency medical services (EMS)-specific research and has called for an increase in funding and infrastructure to support EMS research. We investigated the trends in EMS-specific publications and National Institutes of Health (NIH)-funded research grants in the 20 years since this landmark publication.METHODS: We performed a structured PubMed search of English-language citations from 2001 to 2020 to identify publications with populations, settings, or topics related to EMS care, education, or operations. Publications in trade journals and studies not involving humans were excluded. We also queried NIH Research Portfolio Online Reporting Tools Expenditures and Results (RePORTER) using a similar structured search. Titles, keywords, and abstracts were reviewed. Descriptive statistics were calculated, and nonlinear trends were described using segmented regression models.
    RESULTS: A total of 183,307 references met the search criteria in PubMed, and 4,281 grants were identified in NIH RePORTER. After removing duplicates, 152,408 titles were screened, with 17,314 (11.5%) included. EMS-related publications increased from 419 in 2001 to 1,788 in 2020, a 327% increase, compared with a 197% increase in total PubMed publications. There was a statistically significant nonlinear (J-shaped) increase in EMS publications after 2007. There were 1,166 funded EMS-related NIH grants, with a 469% increase from 2001 to 2020 compared with an 18% increase in overall NIH awards.
    CONCLUSION: Although total publications have doubled in the United States over the past 20 years, EMS-specific research has more than tripled and the number of funded EMS research grants has increased nearly 5-fold. Future evaluation should examine the quality of this research and its application to clinical practice.
    DOI:  https://doi.org/10.1016/j.annemergmed.2023.02.017
  44. World Neurosurg X. 2023 Apr;18 100182
      Objective: To understand trends in neuronavigation we employed machine learning methods to perform a broad literature review which would be impractical by manual inspection.Methods: PubMed was queried for articles with "Neuronavigation" in any field from inception-2020. Articles were designated neuronavigation-focused (NF) if "Neuronavigation" was a major MeSH. The latent dirichlet allocation topic modeling technique was used to identify themes of NF research.
    Results: There were 3896 articles of which 1727 (44%) were designated as NF. Between 1999-2009 and 2010-2020, the number of NF publications experienced 80% growth. Between 2009-2014 and 2015-2020, there was a 0.3% decline. Eleven themes covered 1367 (86%) NF articles. "Resection of Eloquent Lesions" comprised the highest number of articles (243), followed by "Accuracy and Registration" (242), "Patient Outcomes" (156), "Stimulation and Mapping" (126), "Planning and Visualization" (123), "Intraoperative Tools" (104), "Placement of Ventricular Catheters" (86), "Spine Surgery" (85), "New Systems" (80), "Guided Biopsies" (61), and "Surgical Approach" (61). All topics except for "Planning and Visualization", "Intraoperative Tools", and "New Systems" exhibited a monotonic positive trend. When analyzing subcategories, there were a greater number of clinical assessments or usage of existing neuronavigation systems (77%) rather than modification or development of new apparatuses (18%).
    Conclusion: NF research appears to focus on the clinical assessment of neuronavigation and to a lesser extent on the development of new systems. Although neuronavigation has made significant strides, NF research output appears to have plateaued in the last decade.
    Keywords:  Artificial intelligence; Bibliometric; Machine learning; Natural language processing; Neuronavigation; Neurosurgery; Topic modeling
    DOI:  https://doi.org/10.1016/j.wnsx.2023.100182
  45. Cureus. 2023 Feb;15(2): e35553
      Objective To determine the degree to which hospitalists published academic manuscripts related to COVID-19 during the first year of the pandemic. Patients and methods The study was a cross-sectional analysis of the author's specialty, defined by byline or professional online biography, from articles related to COVID-19 published between March 1, 2020, and February 28, 2021. It included the top four internal medicine journals by impact factor: New England Journal of Medicine, Journal of the American Medical Association, Journal of the American Medical Association Internal Medicine, and Annals of Internal Medicine. Participants were all United States (US)-based physician authors contributing to COVID-19 publications. Our primary outcome was the percentage of US-based physician authors of COVID-19 articles who were hospitalists. Subgroup analyses characterized author specialty by authorship position (first, middle, last) and article type (research vs. non-research). Results Between March 1, 2020, and February 28, 2021, the top four US-based medical journals published 870 articles related to COVID-19 of which 712 articles with 1940 US-based physician authors were included. Hospitalists accounted for 4.2% (82) of authorship positions including 4.7% (49/1038) of authorship positions in research articles and 3.7% (33/902) of authorship positions in non-research articles. First, middle, and last authorship positions were held by hospitalists at 3.7% (18/485), 4.4% (45/1034), and 4.5% (19/421) of the time, respectively. Conclusions Despite caring for a large number of patients with COVID-19, hospitalists were rarely involved in disseminating COVID-19 knowledge. Limited authorship by hospitalists could constrain the dissemination of inpatient medicine knowledge, impact patient outcomes, and affect the academic promotion of early-career hospitalists.
    Keywords:  academic research; authorship; covid-19 publications; hospital medicine; promotion
    DOI:  https://doi.org/10.7759/cureus.35553
  46. Cureus. 2023 Mar;15(3): e35688
      Musculoskeletal oncology fellowship directors (MOFDs) possess the unique ability to influence treatment paradigms in musculoskeletal oncology through teaching and research. Currently, the characteristics that define this important role including demographics, training characteristics, research activity, and grant funding are poorly defined. A list of musculoskeletal oncology fellowship programs was obtained from the American Association of Hip and Knee Surgeons and Musculoskeletal Oncology Fellowship Match. Bibliometric data including the h-index were abstracted from Scopus. Demographics, training, and federal grant characteristics were collected from academic websites. Comparisons were made using t-tests and data were presented as means ± SD. The average age at the appointment was 41±9 years and most were male (80%) and Caucasian (85%). Few had an additional graduate degree (10% MS, 5% PhD). The mean h-index was 23±15 resulting from 91±56 publications. There was a positive correlation between age and h-index (r=0.398, p=0.082). Four MOFDs (20%) had at least one National Institutes of Health research grant. Sex, race, additional graduate degree, and procurement of NIH funding were not associated with higher h-index values. Full professors had higher h-index values than assistant/associate professors (p=0.014). Women and racial minorities are underrepresented among leadership positions in musculoskeletal oncology fellowship programs. This study can help provide a benchmark for departments in orthopedic surgery and aspiring orthopedic surgeons for MOFD positions.
    Keywords:  academic; diversity and inclusion; fellowship; leadership; oncology; orthopedic; surgery
    DOI:  https://doi.org/10.7759/cureus.35688
  47. JB JS Open Access. 2023 Apr-Jun;8(2):pii: e22.00090. [Epub ahead of print]8(2):
      With the ever-changing dynamics of surgical training, it is essential for the content of educational research to evolve simultaneously. This study aimed to assess the current state of scholarly work in orthopaedic training education and to identify particular educational topics that are trending in the literature.Methods: A PubMed search string was used to identify literature on orthopaedic surgery education from 2016 to 2021. Publications on orthopaedic surgery education were divided into 8 education-based categories: (1) operative training and simulation, (2) curriculum and career development, (3) diversity, (4) wellness and burnout, (5) program evaluation and match data, (6) trainee assessments, (7) social media, and (8) other. Univariate analysis and linear regression were used to determine trends.
    Results: A total of 383 orthopaedic surgery education publications met inclusion criteria. Orthopaedic surgery education publications accounted for 0.47% of the total publications from all 54 journals. Fifteen journals provided 85% of all orthopaedic education publications (N = 325). The Journal of Bone and Joint Surgery produced the most orthopaedic surgery education publications (76, 20%), followed by the Journal of Surgical Education (62, 16%) and the Journal of the American Academy of Orthopaedic Surgeons (58, 15%). Publications on curriculum and career development were the most common (21.9%). The following most frequent topics were program evaluation and match data (20.9%) and operative training and simulation (18%), respectively. Over the study period, the total amount of orthopaedic surgery education articles increased significantly (R2 = 0.86, p = 0.008). Articles included all levels of training, with resident education accounting for the majority, with 269 articles (70.2%).
    Conclusion: Recent trends in orthopaedic literature indicate an increased emphasis on education as the number of publications has increased, but are still sparse in orthopaedic literature. As the field of orthopaedics continues to advance, we recommend that academic institutions and organizations continue to evaluate and promote evidence-based educational research to ensure that orthopaedic education meets the ever-increasing demands that residents and practicing surgeons will face in the present and future.
    Level of Evidence: III.
    DOI:  https://doi.org/10.2106/JBJS.OA.22.00090
  48. Ann Vasc Surg. 2023 Apr 04. pii: S0890-5096(23)00175-9. [Epub ahead of print]
      BACKGROUND: Despite initiatives to promote equal enrollment of human subjects in clinical trials, females continue to be underrepresented. The goal of this work is to determine if female enrollment in human clinical trials published in three high-impact journals from 2015 to 2019 is correlated with gender of first and/or senior authors.METHODS: Clinical trials published in the Journal of the American Medical Association (JAMA), The Lancet, and the New England Journal of Medicine (NEJM) from January 1, 2015, to December 31, 2019, were reviewed. Trials were excluded for ongoing enrollment, sex-specific disease research, or author name without gender assignment. One-sample χ2 pairwise comparisons and two-tailed proportion tests on the proportion of females between gender author pairings were done overall and for each subset analysis.
    RESULTS: 1,427 articles enrolled a total of 2,104,509 females and 2,616,981 males (44.6% vs. 55.4%, p ≤ 0.0001) in clinical trials. Overall, more females were enrolled if both first and senior authors were female (51.7% vs. 48.3%, p ≤ 0.0001). Proportion of females enrolled decreased with the following first and senior author pairings: female-male (48.9%), male-female (48.6%), and male-male (40.5%, p ≤ 0.0001 compared to female-female authorship). Greater female enrollment in clinical trials with female-female compared to male-male authorship persisted in subset analyses by funding source, phase, randomization for study participants, drug and/or device trial, and geographic location. Female enrollment was higher in 3 surgical specialties: neurosurgery (all authors: 52%, p ≤ 0.01), ophthalmology (all authors: 53.6%, p ≤ 0.0001), and surgery (all authors: 54.4%, p ≤ 0.0001). The majority of surgical specialties did not publish trials with female-female authorship but when stratifying by author gender pairing, surgical oncology had the highest female enrollment with female-female authorship (98.4%, p ≤ 0.0001).
    CONCLUSION: Female authorship of clinical trial publications, specifically having both first and senior authors as female, was correlated with higher female enrollment in clinical trials when compared to male authorship and endured with multiple subset analyses.
    Keywords:  clinical trials; female authorship; gender bias; sex bias
    DOI:  https://doi.org/10.1016/j.avsg.2023.03.008
  49. Nurs Educ Perspect. 2023 Apr 04.
      AIM: The project aims to explore replication, as a concept and practice, in nursing education research.BACKGROUND: Replication practices are important features supporting the science of nursing education. The absence of replication studies in the wider education community raises questions about the potential for similar absences in nursing education. As such, an investigation into replication practices within nursing education provides directions for future discussion.
    METHOD: Using Scopus and databases of nursing education journals, three search strategies were launched to assess replication practices using bibliometric data and content analysis.
    RESULTS: Inconsistency in definitions of the term replication creates barriers to recognizing replication attempts in the body of literature. Based on bibliometric data and content analysis, conceptual replication appears to be common in highly cited nursing education research.
    CONCLUSION: Within the academic nursing community, consensus on the meaning of the term and promotion of practices that support replication is recommended.
    DOI:  https://doi.org/10.1097/01.NEP.0000000000001116
  50. Anesth Analg. 2023 Apr 03.
      BACKGROUND: Although the number of women in medicine has increased, women remain underrepresented in leadership positions, specifically in medical societies. Specialty societies in medicine are influential in networking, career advancement, research and education opportunities, and providing awards and recognition. The goals of this study are to examine the representation of women in leadership positions in anesthesiology societies compared to women society members and women anesthesiologists and to analyze the trend in women society presidents over time.METHODS: A list of anesthesiology societies was obtained from the American Society of Anesthesiology (ASA) website. Society leadership positions were obtained via the societies' websites. Gender was determined by images on the society website and images or pronouns on hospital websites and research databases. The percentage of women presidents, vice presidents/presidents-elect, secretaries/treasurers, board of directors/council members, and committee chairs was calculated. The percentage of women in society leadership positions was compared to the percentage of women society members when available, and the percentage of women anesthesiologists in the workforce (26%) using binomial difference of unpaired proportions tests. The trend of women presidents from 1980 to 2020 was analyzed using a Cochran-Armitage trend test.
    RESULTS: A total of 13 societies were included in this study. Overall, women held 32.6% (189/580) of leadership positions. 38.5% (5/13) of presidents, 17.6% (3/17) of presidents-elect/vice presidents, and 45% (9/20) of secretaries/treasurers were women. In addition, 30.0% (91/303) of board of directors/council members and 34.2% (90/263) of committee chairs were women. The percentage of women holding society leadership positions was significantly greater than the percentage of women anesthesiologists in the workforce (P < .001), as was the percentage of women as committee chairs (P = .003). The percentage of women society members was available for 9 of 13 societies (69%), and the percentage of women leaders was similar to the percentage of women society members (P = .10). There was a significant difference in the percentage of women leaders between society size categories. Small societies had 32.9% (49/149) women leaders, medium had 39.4% (74/188) women leaders, and the single large society had 27.2% (66/243) (P = .03). There were also significantly more women leaders in the Society of Cardiovascular Anesthesiologists (SCA) than there are women members (P = .02).
    CONCLUSIONS: This study suggests that anesthesia societies may be more inclusive of women in leadership positions compared to other specialty societies. Although in anesthesiology, women remain underrepresented in academic leadership roles, there is a higher proportion of women in leadership roles in anesthesiology societies than proportion of women in the anesthesia workforce.
    DOI:  https://doi.org/10.1213/ANE.0000000000006465
  51. Int J STEM Educ. 2023 ;10(1): 23
      The purpose of this study was to conduct a content analysis of research on technology use for teaching mathematics to students with disabilities. We applied word networks and structural topic modeling of 488 studies published from 1980 to 2021. Results showed that the words "computer" and "computer-assisted instruction" had the highest degree of centrality in the 1980s and 1990s, and "learning disability" was another central word in the 2000s and 2010s. The associated word probability for 15 topics also represented technology use within different instructional practices, tools, and students with either high- or low-incidence disabilities. A piecewise linear regression with knots in 1990, 2000, and 2010 demonstrated decreasing trends for the topics of computer-assisted instruction, software, mathematics achievement, calculators, and testing. Despite some fluctuations in the prevalence in the 1980s, the support for visual materials, learning disabilities, robotics, self-monitoring tools, and word problem-solving instruction topics showed increasing trends, particularly after 1990. Some research topics, including apps and auditory support, have gradually increased in topic proportions since 1980. Topics including fraction instruction, visual-based technology, and instructional sequence have shown increasing prevalence since 2010; this increase was statistically significant for the instructional sequence topic over the past decade.
    Keywords:  Mathematics; Research trends  ; Students with disabilities; Technology; Topic modeling; Word networks
    DOI:  https://doi.org/10.1186/s40594-023-00414-x
  52. PLoS One. 2023 ;18(4): e0283106
      In this article, we investigate the role of gender in collaboration patterns by analyzing gender-based homophily-the tendency for researchers to co-author with individuals of the same gender. We develop and apply novel methodology to the corpus of JSTOR articles, a broad scholarly landscape, which we analyze at various levels of granularity. Most notably, for a precise analysis of gender homophily, we develop methodology which explicitly accounts for the fact that the data comprises heterogeneous intellectual communities and that not all authorships are exchangeable. In particular, we distinguish three phenomena which may affect the distribution of observed gender homophily in collaborations: a structural component that is due to demographics and non-gendered authorship norms of a scholarly community, a compositional component which is driven by varying gender representation across sub-disciplines and time, and a behavioral component which we define as the remainder of observed gender homophily after its structural and compositional components have been taken into account. Using minimal modeling assumptions, the methodology we develop allows us to test for behavioral homophily. We find that statistically significant behavioral homophily can be detected across the JSTOR corpus and show that this finding is robust to missing gender indicators in our data. In a secondary analysis, we show that the proportion of women representation in a field is positively associated with the probability of finding statistically significant behavioral homophily.
    DOI:  https://doi.org/10.1371/journal.pone.0283106