bims-evares Biomed News
on Evaluation of research
Issue of 2023–02–19
47 papers selected by
Thomas Krichel, Open Library Society



  1. Curr Probl Cardiol. 2023 Feb 09. pii: S0146-2806(23)00055-5. [Epub ahead of print] 101638
       BACKGROUND/AIM: Statin medications are considered as important lipid lowering agents to prevent subsequent cardiovascular events. However, there was limited evidence regarding the bibliometric analysis on pre-clinical and clinical studies.
    METHODS: In Jan, 2021, the data was retrieved from Scopus and Dimensions database. For detail analysis, we focused on Scopus.
    RESULTS: 33247 research documents were found in the database which contained the word "Statin" either in titles, abstracts and/or keywords of the research documents. They mostly comprised of research articles (n=22586/67.93%), reviews (n=6366/19.15%). Scopus classified these documents in various subject categorized like medicine, biochemistry, genetics and molecular biology, pharmacology, toxicology and pharmaceutics, nursing, neuroscience, biological sciences, immunology and microbiology to name a few. The highest documents are published in 2016 (n=540/7.16%), followed by 2015 (n=534/7.08%), 2017 (n=527/6.99%), 2014 (n=514/6.81%) and 2020 (n=504/6.68%). The top sources as well as total number of authors, institutes and countries involved in publications are described. For detail analysis, we designed the publication and citation clubs. Based on Vosviewer analysis we also provided details about co-authorship network for authors, institutes, and countries. In order to understanding the research focus of the publications, we performed the co-words analysis.
    CONCLUSION: The present study may provide details and research trends about statin publications.
    Keywords:  Citation Clubs; Dimension; Growth Rate; Publication; Scopus
    DOI:  https://doi.org/10.1016/j.cpcardiol.2023.101638
  2. Front Oncol. 2023 ;13 1092870
       Background: Research on tumor organoids has developed rapidly over the past 20 years, but a systematic analysis of current research trends is lacking. Researchers in the field need relevant references and knowledge of current research hot spots. Bibliometric analysis and visualization is a systematic method of acquiring an in-depth understanding of the status of research on tumor organoids.
    Methods: CiteSpace, VOSviewer and the Bibliometric Online Analysis Platform from the Web of Science Core Collection were used to analyze and predict publishing trends and research hot spots worldwide in the field of tumor organoids.
    Results: A total of 3,666 publications on tumor organoids were retrieved, and 2,939 eligible articles were included in the final analysis. The number of publications has grown significantly, with the United States of America as the leading country for research on tumor organoids. Among journals, Cancers published the largest number of articles. Harvard Medical School published the highest number of articles among all institutions. The Chinese Academy of Sciences was ranked highest among all contributing institutions on the importance of their publications. A trend in multi-disciplinary collaboration was observed in studies on tumor organoids. Keywords indicated that the current research largely concentrated on optimizing the construction of organoid models to use for medication development and screening in the clinical setting, and to provide patients with individualized treatment for gastric cancer and colorectal cancer, which are newly emerging research hotspots. Gastric and colorectal cancers were the top two tumors that have received increasing attention and have become the focal points of recent studies.
    Conclusion: This study analyzed 2,939 publications covering the topic of tumor organoids. Although optimizing the construction of organoid models has always been a hot topic in this field, the application of tumor organoids to the development of medications and screenings will foster individualized treatment for patients, which is another emerging hot spot in this field of research.
    Keywords:  CiteSpace; VOSviewer; antioxidant polyphenols; bibliometric analysis; drug screening; precise medicine; tumor organoids
    DOI:  https://doi.org/10.3389/fonc.2023.1092870
  3. Front Immunol. 2023 ;14 1095421
       Introduction: Recent studies have shown much progress in the research of exosomes in AIDs. However, there is no bibliometric analysis in this research field. This study aimed to provide a bibliometrics review of the knowledge structure and research hotspots of neutrophil extracellular traps (NETs) in autoimmune diseases (AIDs).
    Methods: Articles relevant to NETs in AIDs from 2010 to 2022 were retrieved through the Web of Science Core Collection (WoSCC) database. This bibliometric analysis was performed by VOSview, CiteSpace, and Scimago Graphica.
    Results: A total of 289 papers analyzed in this research were from 493 organizations in 47 countries by 1537 authors. They were published in 133 journals and cited 20,180 citations from 2,465 journals. The number of annual publications in this field is growing steadily and rapidly, with the United States, China and Germany leading the research effort. Frontiers in Immunology and Journal of Immunology have significantly impacted research in this field. Kaplan, Mariana J, from the National Institutes of Health (The United States), has the most published articles, and Brinkmann, v, from Max Planck Institute for Infection Biology (Germany), is the most co-cited author. Systemic lupus erythematosus and rheumatoid arthritis are the leading topics in this field. The trend of clinical application in the future is the development of new therapies by controlling NETs in the progression of AIDs.
    Conclusions: Our study summarized the research trends and developments of NETs in AIDs in recent years and would provide a reference for scholars in this field.
    Keywords:  autoimmune disease; bibliometric analysis; neutrophil extracellular traps; rheumatoid arthritis; systemic lupus erythematosus
    DOI:  https://doi.org/10.3389/fimmu.2023.1095421
  4. Matern Child Health J. 2023 Feb 13.
       OBJECTIVE: This study uses a systematic review with bibliometric analysis methods to investigate the characteristics of the most cited research papers in the field of nursing fatigue and pregnancy.
    METHODS: In the Web of Science (WoS) database. We used the keywords "fatigue" and "pregnancy" to search for articles published from 2000 to 2020, limited to SSCI and Science Citation Index (SCI) journal-type articles. This study identifies the most cited studies in the WoS database based on PRISMA guidelines (Preferred reporting items for systematic reviews and meta-analyses). These studies form the research data, then visualized and analyzed using a retrospective bibliometric analysis and VOSviewer.
    RESULTS: The studies in the dataset were analyzed in 319 different journals in 51 countries between 2000 and 2020. The study was found that the United States (US) was the country with the highest yield. The most frequent keywords were postpartum, depression, sleep, and postpartum depression.
    CONCLUSION: The research results further laid the foundation of bibliometrics for scholars and identified researchers, scientific journals, countries, and hot topics for fatigue-related pregnancy literature. Journals with high impact factors contain the most cited research and open new horizons for research in the nursing field of pregnancy-related fatigue, thus providing research inspiration for investigators in this field.
    Keywords:  Depression; Fatigue; Postpartum depression; Pregnancy symptoms
    DOI:  https://doi.org/10.1007/s10995-023-03609-4
  5. J Appl Biomater Funct Mater. 2023 Jan-Dec;21:21 22808000231154065
       OBJECTIVES: Mineral trioxide aggregate (MTA) has a long history of providing predictable clinical outcomes in dental applications especially in endodontic procedures. This bibliometric analysis aimed at evaluating the advancements of research in mineral trioxide aggregate and its use in the field of dentistry, together with the detection of most significant authors, organizations, countries, journals, papers, and the exploration of commonly used keywords using a structured approach.
    MATERIALS AND METHOD: The search was conducted using the Elsevier's Scopus database, gathering publication information related to MTA published from 1993 and 2021 July. Metadata comprising of titles, abstracts, keywords, authors, organizations, and countries were obtained. Bibliometric evaluators with respect to authors, articles published, journals, keywords, and top countries were scrutinized. Data was analyzed using VOS viewer.
    RESULTS: Between 1993 and 2021, an uptrend in the research performed on MTA was identified. Researchers from United States, Brazil, and Iran actively contributed on MTA, while papers from USA were highly cited. The Journal of Endodontics along with International Endodontic Journal were the top contributing academic journals. Hacettepe University, Turkey and Cardiff University from United Kingdom were the top most contributing organizations. Mahmoud Torabinejad was the most cited author. Most commonly used keywords included Mineral trioxide aggregate, silicate, oxide, root canal filling material.
    CONCLUSION: The global rise in the number of publications on mineral trioxide aggregate, tremendous networking and citations have been identified amongst various organizations, authors, and nations through this bibliometric analysis.
    Keywords:  MTA; Scopus; VOSviewer; bibliometric analysis; dentistry
    DOI:  https://doi.org/10.1177/22808000231154065
  6. Acta Biomed. 2023 Feb 13. 94(1): e2023061
       BACKGROUND AND AIM: Von Willebrand disease (VWD) is considered the most prevalent inherited bleeding disorder. The current study aims to demonstrate the research status and trends on VWD worldwide.
    METHODS: Bibliometric analysis was used to investigate the global research productivity and trends on VWD. The publications on VWD from 1956 to 2021 were extracted using the Web of Science database. In the VWD domain, a total of 3,643 records were analyzed for authorship and collaboration patterns, yearly productivity, highly cited documents, relevant source of publication, most prolific scholars, productive countries, and organizations.
    RESULTS: The most productive journal, author, organization, and country were 'Haemophilia' with 439 publications, 'Favaloro EJ' with 119 publications, the 'University of Milan' with 192 publications, and the United States of America (USA) with 1,048 publications, respectively. The document with the highest citations was 'Srivastava A, 2013, Haemophilia,' which received 1,154 citations in total. In 2016, the highest number of publications shared by two author patterns was 28. With 199 publications, the year 2021 remained on the top, while the citation-wise analysis identified 2006 as the top year with 5,379 citations.
    CONCLUSIONS: Research productivity and publication trends on VWD revealed that the USA emerged as the most significant contributing country. The 'University of Milan' was the most significant contributing organization, while 'Favaloro EJ' was the most significant author. 'Hemophilia' was found to be the most significant journal in the field of VWD. It is recommended that researchers from countries with significant contributions to the field should collaborate with researchers from Asian countries and other countries that lack behind in research in the domain of VWD.(www.actabiomedica.it).
    DOI:  https://doi.org/10.23750/abm.v94i1.14086
  7. J Pak Med Assoc. 2023 Feb;73(Suppl 1)(2): S105-S110
       Objectives: The study aimed to identify geographic and gender disparities in the quality, academic impact, and media attention of the top-cited articles related to stem cell-related surgical research.
    METHODS: The following data was extracted for the top 200 most-cited articles (2011-2021): article- (including citation metrics and country of publication), journal- (including impact factor), and author-level (including corresponding author gender) variables. Article Altmetric Attention Score (AAS), a measure of mass mainstream and social media attention, was also recorded.
    RESULTS: Most articles originated from high-income countries (HICs: 175 [87.5%]), with only 7 (3.5%) from lower-middle-income countries. Articles from non-HIC were published in journals with significantly lower impact factors (6.66 [3.75-9.46] vs. 23.2 [7.3-32.5]; p < 0.001) and AAS (7 [3-14.5] vs. 30 [11-83]; p < 0.001). Only 44 (22%) of articles were authored by a female corresponding author, with these having significantly fewer citations than those authored by a male (289 [250-400] vs. 331.5 [267.25-451.25]; p=0.031).
    CONCLUSIONS: Even amongst the top-cited literature, our results demonstrate worrying disparities in the geographic origins of stem cell-related surgical research. The vast majority originates from HICs, with these articles being published in better journals and receiving greater media attention. We also identified significant gender disparities, with female representation being concerningly low and female-authored articles receiving significantly fewer citations.
    Keywords:   Female, Male, social media, Factor IX, Stem Cells.
    DOI:  https://doi.org/10.47391/JPMA.AKUS-17
  8. Nicotine Tob Res. 2023 Feb 15. pii: ntad024. [Epub ahead of print]
       INTRODUCTION: Conduct bibliometric analyses documenting the output of NIH tobacco-related and FDA tobacco regulatory science (FDA-TRS) research portfolios.
    METHODS: PubMed Identifiers for publications between 2015 and 2020 citing tobacco funding by NIH and/or FDA were imported into NIH iCite generating measures of productivity and influence, including number of citations, journal, Relative Citation Ratios (RCR), and comparison of research influence across Web of Science (WoS) disciplines. Co-authorship and measures of centrality among and between NIH and FDA-supported investigators gauged collaboration.
    RESULTS: Between FY 2015 and 2020, 8160 publications cited funding from NIH tobacco-related grants, 1776 cited FDA-TRS grants and 496 cited Common funding (i.e., both NIH and FDA-TRS funding). The proportion of publications citing NIH grants declined while those citing FDA-TRS or Common funding rose significantly. Publications citing Common funding showed the highest influence (mean RCR=2.52). Publications citing FDA-TRS funding displayed higher median RCRs than publications citing NIH funding in most WoS categories. Higher translational progress was estimated over time for FDA-TRS and Common publications compared to NIH publications. Authors citing Common funding scored highest across all collaboration measures.
    CONCLUSIONS: This study demonstrates the high bibliometric output of tobacco research overall. The rise in publications citing FDA-TRS and Common likely reflects increased funding for TRS research. Higher RCRs across WoS subject categories and trends towards human translation among FDA-TRS and Common publications indicate focus on research to inform regulation. This analysis suggests that FDA support for TRS has expanded the field of tobacco control resulting in sustained productivity, influence and collaboration.
    IMPLICATIONS: This paper is the first effort to better describe the impact of tobacco research resulting from the addition of FDA funding for TRS in the past decade. The analysis provides impetus for further investigation into the publication topics and their focus which would offer insight on the specific evidence generated on tobacco control and regulation.
    Keywords:  FDA; NIH; RCR; bibliometrics; grant analysis; tobacco regulatory science
    DOI:  https://doi.org/10.1093/ntr/ntad024
  9. Cureus. 2023 Jan;15(1): e33711
      The aim of the study was to characterise the most frequently cited articles on the topic of hearing implants. A systematic search was carried out using the Thomson Reuters Web of Science Core Collection database. Eligibility criteria restricted the results to primary studies and reviews published from 1970 to 2022 in English dealing primarily with hearing implants. Data including the authors, year of publication, journal, country of origin, number of citations and average number of citations per year were extracted, as well as the impact factors and five-year impact factor of journals publishing the articles. The top 100 papers were published across 23 journals and were cited 23,139 times. The most-cited and influential article describes the first use of the continuous interleaved sampling (CIS) strategy utilised in all modern cochlear implants. More than half of the studies on the list were produced by authors from the United States, and the Ear and Hearing journal had both the greatest number of articles and the greatest number of total citations. To conclude, this research serves as a guide to the most influential articles on the topic of hearing implants, although bibliometric analyses mainly focus on citations. The most-cited article was an influential description of CIS.
    Keywords:  audiology; baha; cochlear implants; hearing aids; sensorineural hearing loss
    DOI:  https://doi.org/10.7759/cureus.33711
  10. Front Surg. 2023 ;10 1046294
       Objective: To evaluate the global research productivity in the field of discectomy for lumbar disc herniation (LDH) through bibliometric analysis and mapping knowledge domains.
    Methods: A systematic literature search was performed on the Web of Science (WoS), including the Science Citation Index Expanded (SCIE) database and PubMed. The number of publications, countries of publications, journals of publications, total citation frequency, impact factors of journals, and Institutional sources were analyzed by Microsoft Excel 2019, the Online Analysis Platform of Bibliometrics, and VOSviewer. Hotspots were also analyzed and visualized based on VOSviewer.
    Results: A total of 2,066 papers were identified. The United States ranked first in the number of total citations (7,970). China ranked first in the number of publications (556, 26.9%), which has surpassed the United States in terms of the number of publications published annually since 2016. Wooridul Spine Hospital published the most papers (43). For journals, Spine has published the largest number of papers (289) in this field with the most citation frequencies (6,607). Hotspots could be divided into three clusters: surgery, lumbar disc herniation, and diagnoses. The most recent topic that appeared was symptomatic re-herniation.
    Conclusions: The United States is the most significant contributor to the development of discectomy for LDH. The current research focus of discectomy on LDH was the comparison between surgical approaches and evaluation of current minimally invasive discectomy. At present, minimally invasive techniques, such as endoscopic discectomy, cannot completely replace non-endoscopic discectomy (open discectomy and microdiscectomy) through bibliometric analysis and mapping knowledge domains.
    Keywords:  bibliometrics; discectomy; keywords; lumbar disc herniation (LDH); research hotspots
    DOI:  https://doi.org/10.3389/fsurg.2023.1046294
  11. J Am Acad Orthop Surg Glob Res Rev. 2023 Feb 01. 7
       INTRODUCTION: Extensive research collaborations exist between high-income countries and low- and middle-income countries (LMICs), although prior work has raised concerns regarding equitable representation among LMIC authors. The goal of this bibliometric analysis was to characterize LMIC authorship among indexed orthopaedic journals and identify factors contributing to disparities in representation.
    METHODS: We identified all articles appearing in orthopaedic journals indexed in MEDLINE and Journal Citation Reports with a focus on LMICs or cohorts between 2009 and 2018. All articles describing research conducted in LMICs or research focused on applications to cohorts in LMIC(s) were included. Author affiliation, article characteristics, and impact factor were assessed for 1,573 articles. Logistic regression models created to identify predictors of LMIC authorship.
    RESULTS: We identified few studies published in indexed journals focused exclusively on LICs. Funded studies were less likely to have LMIC last authors. Compared with articles published in lower impact factor journals, those in journals with a higher impact factor were less likely to have a LMIC first or last author. The greater the number of countries represented per study, the less likely it had a LMIC first or last author.
    CONCLUSION: Our study highlights persistent disparities in authorship from LMICs in indexed orthopaedic journals.
    DOI:  https://doi.org/e22.00168
  12. Medicine (Baltimore). 2023 Feb 17. 102(7): e33038
       BACKGROUND: Brugada syndrome (BrS) is a genetic disorder characterized by a typical electrocardiogram pattern and predisposition to arrhythmias and sudden cardiac death. Despite our considerably evolved understanding of BrS, no bibliometrics have been performed in this research field. We aimed to analyze and visualize the characteristics of the scientific outputs, topical evolutions, and research trends of BrS over the past 2 decades using bibliometric analysis.
    METHODS: The literature associated with BrS was retrieved from the Science Citation Index Expanded of the Web of Science Core Collection database. Acquired data were then visually analyzed using CiteSpace and VOSviewer.
    RESULTS: 3042 qualifying records were included in the final analysis. The publication outputs increased over time. The United States was the leading country in the BrS research. The University of Amsterdam (Netherlands) was the most prolific and influential institution. Pedro Brugada, Arthur Wilde, and Charles Antzelevitch exerted notable publication impact and made the most significant contributions in the field of BrS. Heart Rhythm had the highest outputs and Circulation was the most influential journal. Bundle branch block, ST-segment elevation, mechanism, management, right precordial lead, and guideline were the keywords with the strongest citation burst.
    CONCLUSION: Research on BrS is prosperous. Keywords and co-citation analysis revealed that the mechanism, diagnosis, risk stratification, and management of BrS were the research hotspots. Besides, the underlying pathophysiology, novel therapies, and personalized risk assessment might be the emerging trends of future research.
    DOI:  https://doi.org/10.1097/MD.0000000000033038
  13. An Acad Bras Cienc. 2023 ;pii: S0001-37652023000100701. [Epub ahead of print]95(1): e20220716
      The aim of this study was to use bibliometric techniques to provide a longitudinal view of the evolution over more than 50 years of the literature on esophageal cancer without focusing on a specific area. The Web of Science Core Collection database was searched for published articles on esophageal neoplasm. Different aspects of the articles were analyzed - country, journal, authors, keywords, and topics. The search returned 24,215 articles - the journal Diseases of the Esophagus present the most number of manuscripts (n = 858), followed by Annals of Surgical Oncology (n = 475).The most cited article was one by van Hagen et al. (2012) (2,807 citations). The most prevalent topic was oncology (n = 10,448), followed by surgery (n = 4,944). Most articles were original research (n = 22,697), mainly with the basic science study design and published by institutions in China. The analysis of the variables chosen, identified China as the country with the highest number of articles and showed that authors and institutions in Asia stand out when it comes to production of scientific information on esophageal cancer.
    DOI:  https://doi.org/10.1590/0001-3765202320220716
  14. Clin Exp Med. 2023 Feb 16.
      As a common chronic liver disease, nonalcoholic fatty liver disease (NAFLD) has attracted increasing attention in the past decade. Nevertheless, there are few bibliometric analyses that systematically study this field as a whole. This paper explores the latest research progress and future research trends of NAFLD through the method of bibliometric analysis. The articles related to NAFLD, published from 2012 to 2021 in the Web of Science Core Collections, were searched on February 21, 2022, using relevant keywords. Two different scientometrics software tools were used to conduct the knowledge maps of NAFLD research field. A total of 7975 articles on NAFLD research were included. From 2012 to 2021, the publications related to NAFLD increased by year. China ranked on the top of the list with 2043 publications, and the University of California System emerged as the premier institution in this field. PLOs One, Journal of Hepatology and Scientific Reports became the prolific journals in this research field. Co-cited reference analysis revealed the landmark literature in this research field. In terms of potential hotspots, the burst keywords analysis revealed that liver fibrosis stage, sarcopenia, and autophagy will become the focus of future NAFLD research. The annual output of the global publications in the field of NAFLD research showed a strong upward trend. Research in the field of NAFLD in China and America is more mature than in other countries. Classic literature lays the foundation for research, and multi-field studies provide the new development directions. And besides, fibrosis stage, sarcopenia and autophagy research are the hot spots and frontiers of this field.
    Keywords:  Bibliometric analysis; CiteSpace; Nonalcoholic fatty liver disease; VOSviewer; Visualization
    DOI:  https://doi.org/10.1007/s10238-023-01023-2
  15. World Neurosurg. 2023 Feb 14. pii: S1878-8750(23)00186-9. [Epub ahead of print]
       BACKGROUND: Moyamoya disease (MMD) is a rare cerebrovascular disease in neurology. This study investigates the literature related to MMD from its discovery to the present and identified research levels, achievements, and trends.
    METHODS: All publications from its discovery to present on MMD are downloaded from the Web of Science Core Collection on September 15, 2022 and bibliometric analyses are visualized by HistCite Pro, VOSviewer, Scimago Graphica, CiteSpace and R language.
    RESULTS: There were 3414 papers in 680 journals by 10522 authors, 2441 institutions and 74 countries/regions all over the world are included in the analyses. Since the discovery of MMD, output of publications shows an upward trend. Japan, the USA, China and South Korea are four major countries to MMD field. United States has the strongest cooperation with other countries. China's Capital Medical University is the output-leading institution in the world, followed by Seoul National University and Tohoku University. The three authors with the most published articles are Kiyohiro Houkin, Dong Zhang and Satoshi Kuroda. World Neurosurgery, Neurosurgery and Stroke are the most recognized journals for researchers. "Hemorrhagic moyamoya disease", "susceptibility gene" and "arterial spin" are the primary focus areas of MMD research. "Rnf213," "vascular disorder,", and "progress" are the top keywords.
    CONCLUSIONS: We analyzed publications of global scientific research on MMD systematically by bibliometric methods. This study can provide one of the most comprehensive and accurate analyses for MMD scholars worldwide.
    Keywords:  CiteSpace; HistCite; VOSviewer; bibliometrics; emerging topics; moyamoya disease; visualization
    DOI:  https://doi.org/10.1016/j.wneu.2023.02.047
  16. Neurosurg Rev. 2023 Feb 14. 46(1): 57
      Central neurocytoma is the most common primary intraventricular tumor in adults being classified by the World Health Organization (WHO) as a benign grade II tumor with a good prognosis. Given the recent advances with regard to this tumor, a bibliometric analysis was due to study the future direction of research for neurocytomas. A comprehensive Elsevier's Scopus database search was performed to capture all published and indexed studies to date relevant to neurocytoma. A discrete set of validated bibliometric parameters were extracted and analyzed on R v4.1.3. A total of 1002 documents were included in our analysis covering a period between 1910 and 2021 (111 years). Around 98.5% of the documents were multi-author publications with a collaboration index (CI) of 4.21. Acta Neuropathologica, The American Journal of Surgical Pathology, and Cancer were the journals to include the highest number of top ten cited articles (2 out of 10 most cited articles, 20%). Switzerland (4 out of 10, 40%) accounted for the country to have the highest number of top 10 most cited articles with the USA (5588 out of 16,395 citations, 34.1%) having the greatest number of citations. Lastly, our analysis reported an annual growth rate of 6.9% for the number of papers produced by year. This is the first bibliometric analysis to study the top 10 most cited articles with regard to neurocytomas. A shift from histopathologic and clinical symptoms towards the treatment and management of the tumor was observed in our analysis.
    Keywords:  Bibliometric analysis; Brain tumor; Central neurocytoma; Extraventricular tumor; Intraventricular tumor; Neurocytoma
    DOI:  https://doi.org/10.1007/s10143-023-01960-2
  17. Front Cardiovasc Med. 2023 ;10 1076093
       Background: Sepsis-induced myocardial dysfunction (SIMD) has a significant contribution to sepsis-caused death in critically ill patients. In recent years, the number of published articles related to SIMD has increased rapidly. However, there was no literature that systematically analyzed and evaluated these documents. Thus, we aimed to lay a foundation for researchers to quickly understand the research hotspots, evolution processes and development trends in the SIMD field via a bibliometric analysis.
    Methods: Articles related to SIMD were retrieved and extracted from the Web of Science Core Collection on July 19th, 2022. CiteSpace (version 6.1.R2) and VOSviewer (version 1.6.18) were used for performing visual analysis.
    Results: A total of 1,076 articles were included. The number of SIMD-related articles published each year has increased significantly. These publications mainly came from 56 countries, led by China and the USA, and 461 institutions, but without stable and close cooperation. As authors, Li Chuanfu published the most articles, while Rudiger Alain had the most co-citations. Shock was the journal with the most studies, and Critical Care Medicine was the most commonly cited journal. All keywords were grouped into six clusters, some of which represented the current and developing research directions of SIMD as the molecular mechanisms.
    Conclusion: Research on SIMD is flourishing. It is necessary to strengthen cooperation and exchanges between countries and institutions. The molecular mechanisms of SIMD, especially oxidative stress and regulated cell death, will be critical subjects in the future.
    Keywords:  CiteSpace; VOSviewer; bibliometric; sepsis-induced myocardial dysfunction; visual analysis
    DOI:  https://doi.org/10.3389/fcvm.2023.1076093
  18. Environ Sci Pollut Res Int. 2023 Feb 17.
      In recent years, excessive emissions of carbon dioxide have further intensified global warming, which poses a great threat to human society. The best way to reverse this situation is to take action to equalize the "carbon emissions" with the "carbon absorption," i.e., carbon neutrality (CN). To better understand the evolution and display a broad panorama of CN research, this paper provides a comprehensive bibliometric analysis of publications in the field of CN from 2006 to 2021. We use the Web of Science Core Collection as the data source, and a total of 633 publications have been retrieved. In the paper, we measure the productivity and influence of publications through recognized bibliometric metrics, and visually analyze publications using VOS Viewer and CiteSpace. The analysis results show that China is the most productive country/region. The study illustrates that in order to reach the goal of CN, it is necessary to reduce carbon emissions such as full using renewable energy. Simultaneously, it is also essential to enhance the "negative emissions" of carbon such as taking advantage of carbon sink and carbon capture, utilization, and storage. This paper provides some references for scholars who are interested or research in this field.
    Keywords:  Bibliometric analysis; Carbon neutrality; Collaboration network; Development trends; Timeline analysis; Visualization
    DOI:  https://doi.org/10.1007/s11356-023-25797-w
  19. Front Cell Infect Microbiol. 2022 ;12 1108378
       Background: Spasmolytic polypeptide expression metaplasia (SPEM) occurs in the corpus of the stomach and is closely related to inflammations caused by H. pylori infection. Recently, SPEM was suggested as one of the dubious precancerous lesions of gastric cancer (GC). Thus, further research on SPEM cell transdifferentiation and its underlying mechanisms could facilitate the development of new molecular targets improving the therapeutics of GC. Using bibliometrics, we analyzed publications, summarized the research hotspots and provided references for scientific researchers engaged in related research fields.
    Methods: We searched the Web of Science Core Collection (WoSCC) for publications related to SPEM-GC from 2002 to 2022. The VOSviewer, SCImago, CiteSpace and R software were used to visualize and analyze the data. Gene targets identified in the keyword list were analyzed for functional enrichment using the KEGG and GO databases.
    Results: Of the 292 articles identified in the initial search, we observed a stable trend in SPEM-GC research but rapid growth in the number of citations. The United States was the leader in terms of quality publications and international cooperation among them. The total number of articles published by Chinese scholars was second to the United States. Additionally, despite its low centrality and average citation frequency, China has become one of the world's most dynamic countries in academics. In terms of productivity, Vanderbilt University was identified as the most productive institution. Further, we also observed that Gastroenterology was the highest co-cited journal, and Goldenring Jr. was the most prolific author with the largest centrality.
    Conclusion: SPEM could serve as an initial step in diagnosing gastric precancerous lesions. Current hotspots and frontiers of research include SPEM cell lineage differentiation, interaction with H. pylori, disturbances of the mucosal microenvironment, biomarkers, clinical diagnosis and outcomes of SPEM, as well as the development of proliferative SPEM animal models. However, further research and collaboration are still required. The findings presented in this study can be used as reference for the research status of SPEM-GC and determine new directions for future studies.
    Keywords:  bibliomeric analysis; gastric carcinogenesis (SGC-7901); gastric precancerous lesions; helicobacter pylori infection (H. pylori infection); spasmolytic polypeptide-expressing metaplasia (SPEM); visualization
    DOI:  https://doi.org/10.3389/fcimb.2022.1108378
  20. Schizophr Res. 2023 Feb 10. pii: S0920-9964(23)00055-5. [Epub ahead of print]254 35-36
      
    DOI:  https://doi.org/10.1016/j.schres.2023.02.013
  21. Front Oncol. 2023 ;13 1111985
       Background: Currently, malignant peripheral nerve sheath tumors (MPNST) are the subject of intense research interest. However, bibliometric studies have not been conducted in this field. The purpose of the study was to identify historical trends and presents a bibliometric analysis of the MPNST literature from 2000 to 2022.
    Methods: For the bibliometric analysis, publications were retrieved from the Web of Science database based on the following search terms: [TI = (MPNST) OR TI= (malignant peripheral nerve sheath tumors) AND PY = (2000-2022)]. The following information was collected for each document: the publication trends and geographical distribution, important authors and collaboration, keyword distribution and evaluation, most popular journals, and most influential articles.
    Results: We included 1400 documents for bibliometric analysis, covering five categories: 824 articles, 17 proceedings papers, 68 letters, 402 meeting abstracts, and 89 reviews. Corrections, editorials, book chapters, data papers, publications with expressed concerns, and retractions were excluded from our research.
    Conclusion: Since 2000, the number of publications on MPNST has continuously increased. Among all countries that contributed to the MPNST research, the USA, Japan, and China were the three most productive countries. The journal Modern Pathology has the most publications on MPNST, while those in the Cancer Research journal were the most frequently cited. The University of Texas MD Anderson Cancer Center may be a good partner to collaborate with. Recent research trends in MPNST have focused on tumorigenesis, clinical management, and predictive biomarkers.
    Keywords:  RStudio; VOSviewer; bibliometric analysis; cancer; malignant peripheral nerve sheath tumors
    DOI:  https://doi.org/10.3389/fonc.2023.1111985
  22. Biomass Convers Biorefin. 2023 Feb 10. 1-16
      The rising demand to settle a sustainable energy source is guiding researchers in the production of biofuels. The liquefaction process is an alternative to obtaining biocrude from different types of renewable biomass and can mitigate environmental impacts. All papers published since 2000, which are related to the hydrothermal liquefaction process that aims to obtain biocrude are analyzed in the present study using the bibliometric approach to provide the selected database. Furthermore, the use of algae biomass in the liquefaction was also a discussed topic considering its high relevance in the process. The focus of the present study was to evaluate the evolution of the current state of the art in these topics and also to indicate trends and courses that it might be taken in the future. The database used in the bibliometric analysis was taken from the Web of Science (WoS) and the papers were selected by two different search equations. With the selected data, the use of BibExcel, VOSviewer, and PowerBi software was useful to guide the discussion and to create graphics and visual networks. As shown in the results, it was noticeable the influence of China and the USA on the field, considering the high number of publications from these countries. Moreover, the main authors were indicated considering their citation numbers, publications, and local h-index factor. Based on the author's keywords, the most significant and recent topics on liquefaction were listed. Among them, technical-economic analysis, nutrient, and energy recovery, response surface methodology, and kinetic model are highlighted. This may indicate a new direction being taken by researchers besides the operational parameters' studies.
    Graphical Abstract:
    Keywords:  Algae; Bibliometric analysis; Biocrude; Hydrothermal liquefaction (HTL); Microalgae; Schematic review
    DOI:  https://doi.org/10.1007/s13399-023-03905-7
  23. Asian J Psychiatr. 2023 Feb 10. pii: S1876-2018(23)00066-7. [Epub ahead of print]83 103512
      
    Keywords:  Bibliometric Analysis; Indicators; OCD; Scopus; Top authors
    DOI:  https://doi.org/10.1016/j.ajp.2023.103512
  24. Environ Dev Sustain. 2023 Feb 04. 1-28
      Over the last decade, many academics, practitioners, and policy-makers have focused on the notion of circular economy (CE) as a way to operationalize sustainable development. There is, however, a shortage of review studies that reflect the evolution and status of CE with respect to sustainability in the maritime industry. The purpose of this study is to conduct a bibliometric analysis of the development of CE in research on sustainable maritime processes/operations in the maritime industry. To accomplish this, the study uses citation analysis (publication distribution, productive journals, cross-country collaborations), co-occurrence analysis of the subject categories, co-citation analysis, and keyword frequency analysis. To collect data, the study utilizes the Web of Science database. Such software packages as CiteSpace, Histcite, and VOSviewer are used to analyze the data collected. The results clarify that, in the maritime industry, CE is a micro-level sub-set of sustainability. Furthermore, the literature has mainly focused on waste management and life-cycle assessment as measures of CE 1.0 and CE 2.0, respectively. Assessing circularity in terms of R-imperatives highlights that "recycle," "remanufacture," "recover," and "reduce" are widespread practices of circularity in the maritime industry. Shipping companies should evaluate the possibility of implementing CE by realizing shorter loop R-imperatives such as "refuse," "reduce," "reuse," and "repair." Scholars must further explore underdeveloped R-imperatives such as "refuse," "refurbish," "repurpose," and "remine" in the maritime industry.
    Keywords:  Bibliometric analysis; Circular economy; Sustainability; The maritime industry
    DOI:  https://doi.org/10.1007/s10668-023-02942-6
  25. Front Public Health. 2023 ;11 1039782
       Background: Patients with inflammatory bowel disease (IBD) often require immunosuppressive therapy and are hence susceptible to various opportunistic viral and bacterial infections. In this regard, many studies on IBD and COVID-19 have been conducted. However, no bibliometric analysis has been performed. This study provides a general overview of IBD and COVID-19.
    Methods: Publications about IBD and COVID-19 from 2020 to 2022 were retrieved from the Web of Science Core Collection (WoSCC) database. Bibliometric analysis was performed using VOSviewer, CiteSpace, and HistCite.
    Results: A total of 396 publications were retrieved and considered in this study. The maximum number of publications were from the United States, Italy, and England, and the contributions of these countries were significant. Kappelman ranked first in article citations. The Icahn School of Medicine at Mount Sinai and Inflammatory Bowel Diseases were the most prolific affiliation and journal, respectively. The most influential research topics were "management", "impact", "vaccination", and "receptor". The following keywords represented research frontiers: "depression", "the quality of life of IBD patients", "infliximab", "COVID-19 vaccine", and "second vaccination".
    Conclusions: Over the past 3 years, most studies on IBD and COVID-19 have focused on clinical research. In particular, topics such as "depression", "the quality of life of IBD patients", "infliximab", "COVID-19 vaccine", and "second vaccination" were noted to have received much attention recently. Future research should focus on our understanding of the immune response to COVID-19 vaccination in biologically treated patients, the psychological impact of COVID-19, IBD management guidelines, and the long-term impact of COVID-19 in IBD patients. This study will provide researchers with a better understanding of research trends on IBD during COVID-19.
    Keywords:  COVID-19; CiteSpace; VOSviewer; bibliometric analysis; inflammatory bowel disease; trends
    DOI:  https://doi.org/10.3389/fpubh.2023.1039782
  26. BMJ Glob Health. 2023 Feb;pii: e011053. [Epub ahead of print]8(2):
       BACKGROUND: Authors from low and middle-income country (LMIC) institutions are under-represented in publications of research based in LMICs. This case study of publications from authors within the Medical Research Council International Statistics and Epidemiology Group (MRC-ISEG), a global health research group affiliated to the London School of Hygiene & Tropical Medicine in the UK, aims to describe patterns in authorship and factors associated with under-representation.
    METHODS: Papers were included if they were published between January 2016 and December 2020 inclusive, included an author from the MRC-ISEG and described work conducted in a LMIC. Authors' affiliations were classified using World Bank country income classifications into LMIC affiliations only, high-income country (HIC) affiliations only and mixed LMIC/HIC affiliations. Multinomial logistic regression analysis was used to assess associations of author affiliation category with authorship position, and whether patterns varied by journal impact factor quartile and multiple versus single-country studies.
    RESULTS: A total of 882 papers, including 10 570 authors describing research conducted in 61 LMICs, were included. Compared with authors of HIC-only affiliation, those with LMIC-only affiliation were less likely to be in first authorship position (relative risk ratio (RRR)=0.51, 95% CI 0.44 to 0.60) and mixed HIC/LMIC affiliation authors were more likely (RRR=2.80, 95% CI 2.35 to 3.34). Compared with authors of HIC-only affiliation, those with LMIC-only affiliation were less likely to be in last authorship position (RRR=0.20, 95% CI 0.16 to 0.24) and those with mixed HIC/LMIC affiliations were more likely (RRR=1.95, 95% CI 1.65 to 2.30). The proportion of senior authors with LMIC-only affiliation was lowest for the highest impact journals, and in multicountry versus single-country studies.
    CONCLUSION: Alongside increasing research capacity within LMICs, HIC institutions should ensure that LMIC-affiliated researchers are properly represented in global research. Academics working in global health should be judged on their involvement in representative collaborative research rather than individual achievements in authorship position.
    Keywords:  epidemiology
    DOI:  https://doi.org/10.1136/bmjgh-2022-011053
  27. J Refract Surg. 2023 Feb;39(2): 78-88
       PURPOSE: To provide a comprehensive analysis of the most highly cited articles and authors in refractive surgery.
    METHODS: The Scopus database was searched for articles pertaining to refractive surgery using multiple search terms to identify the top 100 most cited articles in refractive surgery. A publicly available database of more than 100,000 scientists that provides standardized information on multiple variables resulting in a composite indicator (C score) was searched to identify refractive surgery authors. A refractive surgery-specific composite score was created using only the authors' publications that were directly related to refractive surgery.
    RESULTS: The 100 most cited articles and 40 refractive surgery authors with the highest ranked C score were identified. The article with the most citations by Trokel et al has garnered nearly 800 citations to date. All articles included in the top 100 had 200 or more citations. The peak publication years were 1998 to 2001. Laser in situ keratomileusis (22), photorefractive keratectomy (18), and postoperative corneal ectasia and/or corneal biomechanics (16) were the most represented topics. Emory University generated the most articles (7) and the majority of publications (48%) originated in the United States. Steven E. Wilson, MD, had the highest refractive C score and Jorge L. Alió, MD, PhD, had the most refractive surgery articles and citations. Among all authors listed, the average number of refractive surgery publications was 97, with 35% of the group having more than 100 refractive surgery articles published. All authors on the list had more than 2,000 citations for their refractive surgery articles, whereas 38% had 4,000 or more citations.
    CONCLUSIONS: This list provides a comprehensive assessment of the most cited articles and authors in refractive surgery and demonstrates key focuses and trends in the field over time. [J Refract Surg. 2023;39(2):78-88.].
    DOI:  https://doi.org/10.3928/1081597X-20221213-01
  28. HSS J. 2023 Feb;19(1): 37-43
      Background: Given the increasing interest and potential use of social media for the promotion of orthopedic literature, there is a need to better understand Altmetrics. Purposes: We sought to determine the relationship between the Altmetric Attention Score (AAS) and the number of citations for articles on total joint arthroplasty (TJA) published in orthopedics journals. We also sought to determine the predictors of greater social media attention for these articles. Methods: Articles on TJA published in Bone and Joint Journal (BJJ), Journal of Bone and Joint Surgery (JBJS), Clinical Orthopedics and Related Research (CORR), Journal of Arthroplasty, Journal of Knee Surgery, Hip International, and Acta Orthopaedica in 2016 were extracted (n = 498). One-way analysis of variance with Bonferroni corrections was used to compare AAS and citations across journals. Multivariate regressions were used to determine predictors of social media attention and number of citations. Results: The mean AAS and number of citations were 7.5 (range: 0-289) and 16.7 (range: 0-156), respectively. Significant between-group effects were observed according to journal for AAS and number of citations. Publishing an article in JBJS was the strongest predictor of higher number of citations. Publishing an article in BJJ was the only independent predictor of higher AAS, while publishing an article in JBJS or CORR trended toward statistical significance. A higher AAS was a significant predictor of a higher number of citations. Number of citations and number of study references were positive predictors of greater social media attention on Twitter and Facebook. Conclusions: In articles on TJA published in 7 journals in 2016, a higher AAS was a associated with a higher number of citations. Various bibliometric characteristics were found to be significantly associated with greater social media attention; the most common influences were number of citations and number of references. Researchers in orthopedics can use this information when considering how to assess the impact of their work.
    Keywords:  Altmetrics; arthroplasty; bibliometrics; citations; hip; knee; social media
    DOI:  https://doi.org/10.1177/15563316221115723
  29. Front Oncol. 2023 ;13 1095852
       Objective: Numerous studies focusing on sedentary behavior (SB) and physical activity (PA) in the context of cancer have been reported in recent years. We analyzed and visualized studies on SB and PA in patients with cancer over the last 20 years using scientometric methods, to provide insights on gaps and deficiencies in the literature, and to inform future research guidelines.
    Methods: All relevant studies in the field from 2001 to October 2022 were reviewed using bibliometric tools, including VOSviewer, Bibliometric online analysis platform, and biblioshiny, to determine the most influential countries, institutions, journals, and authors. We explored current research hotpots and potential research trends, based on keyword clustering and dynamic changes. Our research focuses on PA, SB, and cancer across the entire cancer continuum, from primary prevention to treatment to cancer survivorship.
    Results: Scientometric analysis identified 4,382 relevant manuscripts on SB and PA in the context of cancer, with a 10-fold increase in articles over the past 20 years. The United States, Canada, and Australia were the most influential countries. The journal, Supportive Care in Cancer, had the highest number of publications, while Clinical Oncology had the highest H-index. K.S. Courneya was the most influential author in this field, with the highest number of publications, total citations, and H-index. Keyword analysis revealed that current research is focused on PA and SB in patients with breast cancer, quality of life, and aerobic exercise. Future frontiers include cancer prehabilitation programs and cardiorespiratory fitness, and remote intervention and social support.
    Conclusion: By using bibliometrics, we conducted a comprehensive review of SB and PA in cancer-related studies. The current research focused on exercise and sedentariness in breast cancer patients and the role of PA in improving quality of life in survivorship. Emerging research foci were generally around cancer prehabilitation programs and remote intervention issues for PA. In addition, some publication deficits are noted: studies of PA and SB in less common cancers; the recommended doses and intensities of exercise for cancer; the timing of interventions for prehabilitation and the establishment of individualized exercise protocols. These deficiencies align with the needs for future research topics.
    Keywords:  bibliometrics analysis; cancer; global research; physical activity; sedentary behavior
    DOI:  https://doi.org/10.3389/fonc.2023.1095852
  30. Curr Pediatr Rev. 2023 Feb 14.
       INTRODUCTION: The amount of research exploring the use of virtual reality [VR] and augmented reality [AR] technologies in health care has exploded. This has resulted in a massive body of work, making it difficult to obtain all of the research. The objective of this study was to map out and put together the scientific output of research and global trends in virtual and AR in pediatrics.
    METHOD: Publications were collected from the Web of Science [WoS] database. The R tool was used to categorize and evaluate the research outputs, as well as the most productive and influential countries, journals, institutions, authors, articles, subject areas, and the latest research themes. The most utilized and co-occurring keywords were also examined. Texts, tables, and images were used to assess and describe the retrieval of findings.
    RESULTS: The research was based on information from 7423 publications. The strongest growth in publications occurred in 2020. The most productive and influential country was the USA. The journal was Pediatrics, the author was G Riva, and the institution was the University of Washington. The most frequently occurring keywords were simulation, rehabilitation, and stroke. The main research themes were therapy, surgical education, and rehabilitation. Pain, stroke, anxiety, depression, fear, dementia, and neurodegenerative illnesses were all common medical issues investigated.
    CONCLUSION: VR studies have mainly focused on surgical education or procedures, simulation technologies, and neurological conditions. Neurological conditions are linked to balance, gait, and rehabilitation, reflecting the prevalence of these disease groups. This article provides a thorough overview of VR and AR studies in the healthcare field. This work will allow academics, policymakers, and practitioners to gain a deeper understanding of the evolution of VR and AR studies in the healthcare field and its potential practical implications. Future VR and AR research should focus on bridging the gap between VR and AR healthcare research and clinical applications. Emerging trends in related fields, such as navigation, rehabilitation, stroke, dementia, and VR exposure therapy, should be given special attention.
    Keywords:  augmented reality; bibliometric; pediatrics; simulation; virtual reality
    DOI:  https://doi.org/10.2174/1573396319666230214103103
  31. J Otolaryngol Head Neck Surg. 2023 Feb 16. 52(1): 17
       BACKGROUND: The advancement of Otolaryngology-Head and Neck Surgery (OHNS) as a specialty relies on excellence in research. The Journal of Otolaryngology-Head and Neck Surgery is an open access, peer-reviewed journal publishing on all aspects and subspecialities of OHNS. It is the official journal of the Canadian Society of Otolaryngology-Head and Neck Surgery. This study aims to analyze bibliometric trends in authorships and institutional contributions within the Journal of Otolaryngology-Head and Neck Surgery over a 9-year period.
    METHODS: All research articles published online in the journal were analyzed from 2013 to the end of 2021. The professional designation of all authors was recorded along with the article type, article category, institutional affiliations and international collaborations. Cochran-Armitage trend tests were used to assess the change in proportion over time between years and groups.
    RESULTS: Of the 603 articles, 20 were excluded as they represented correspondence or corrections, or author identity could not be determined. 583 articles with 3409 total authors were included. Number of first authors with a Doctor of Medicine (MD) degree decreased from 90.2 to 85.3% (P = 0.165). Sub-group analysis of non-MD first authors demonstrated a significant increase in medical students as first authors from 1.6 to 11.8% (P = 0.008). Senior author degree demonstrated a significant increase in MD degree from 96.7 to 98.5% (P = 0.002). Analysis of article categories demonstrated a significant decrease in education and head and neck surgery related articles from 8.2 to 2.9% (P = 0.032) and 44.3 to 29.4% (P = 0.028) respectively. Pediatric otolaryngology articles increased significantly from 0 to 5.9% (P < 0.0001). Systematic and scoping reviews significantly increased, from 3.3 to 10.3% (P = 0.015) and original research significantly decreased from 83.6 to 82.4% (P < 0.0001). There was a significant decrease in Canadian/international collaborations from 14.3 to 4.7% (P = 0.037). There was a significant increase in international first and senior authors, from 23.0 to 36.8% (P = 0.008) and 19.7 to 38.2% (P = 0.002) respectively.
    CONCLUSION: The landscape of the journal is evolving with increased representation of non-MDs and international authors along with content that reflects higher level of scientific evidence. Future studies should characterize trends in other Otolaryngology journals to understand the research trajectory within the field.
    Keywords:  Bibliometrics; Evidence-based medicine; International collaborations; Otolaryngology
    DOI:  https://doi.org/10.1186/s40463-022-00619-0
  32. Educ Technol Res Dev. 2023 Feb 07. 1-22
      Educational research is reflective of the nature and structure of national and regional education systems and their historical evolution. Educational technology research, as an area within educational research, reflects this case particularly prominently. Although individual countries and regions have varying research traditions, the publication of research in English as the scientific lingua franca can lead to missing nuances in terminology, which is often not reflected upon. Despite this, the exploration of research from different countries can still uncover diverse topical clusters. This study aims to identify the research topics in educational technology research in three countries (Germany, Spain and the United Kingdom), each with their own research traditions, through the terms used. To this end, a bibliometric analysis of 3034 article abstracts and keywords from 29 English-language Web of Science journals in the field of education and educational research was conducted, with a focus on educational technology. In addition, the quantitative findings are comparatively analysed by considering the corresponding cultural clusters. Main findings include diverse research foci in the three countries, also showing that distinct research traditions are still present, despite using English as lingua franca. Therefore, research articles written in English by non-English authors often do not reflect the same meanings in each country, despite using the same words. The conclusions reflect upon the need to establish ways of understanding the traditions behind those research articles and build collaborative systems to illustrate nuances in this research.
    Keywords:  Bibliometric analysis; Comparative research; Educational research traditions; Educational technology research
    DOI:  https://doi.org/10.1007/s11423-023-10195-3
  33. Front Oncol. 2023 ;13 1067305
       Introduction: In recent decades, single-cell sequencing technology has developed rapidly and used widely in various fields of life sciences, especially for the detection of immune cells. A bibliometric analysis of single-cell sequencing research work on immune cells published during the 2011-2021 period should provide new insight on the use of single-cell sequencing.
    Methods: We screened 1,460 publications on single-cell sequencing on immune cells according to the publication date, article type, language, and country.
    Reults: The United States published the first and largest number of articles, while China's research started relatively late, but ranked second in the number of publications. T cells were the most commonly studied immune cells by single-cell sequencing, followed by mononuclear macrophages. Cancer biology was the most common field of immune cell research by single-cell sequencing. Single-cell sequencing studies using γδ T cells were mainly in the fields of cancer biology and cell development, and focused over time from cell surface receptor to cell function. Through in-depth analysis of the articles on single-cell sequencing of T cells in the oncology field, our analysis found that immunotherapy and tumor microenvironment were the most popular research directions in recent years.
    Discussion: The combination of DNA damage repair and immunotherapy seems to provide a new strategy for cancer therapy.
    Keywords:  DNA damage repair; T cell; bibliometric analysis; immune cells; immunotherapy; single-cell sequencing
    DOI:  https://doi.org/10.3389/fonc.2023.1067305
  34. Accid Anal Prev. 2023 Feb 10. pii: S0001-4575(23)00043-X. [Epub ahead of print]184 106996
      Cyclist safety is a research field that is gaining increasing interest and attention, but still offers questions and challenges open to the scientific community. The aim of this study was to provide an exhaustive review of scientific publications in the cyclist safety field. For this purpose, Bibliometrix-R tool was used to analyse 1066 documents retrieved from Web of Science (WoS) between 2012 and 2021. The study examined published sources and productive scholars by exposing their most influential contributions, presented institutions and countries most contributing to cyclist safety and explored countries open towards international collaborations. A keywords analysis provided the most frequent author keywords in cyclist safety shown in a word cloud with E-bike, behaviour, and crash severity representing the primary keywords. Furthermore, a thematic map of cyclist safety field drafted from the author's keywords was identified. The strategic diagram is divided in four quadrants and, according to both density and centrality, the themes can be classified as follows: 1) motor themes, characterized by high value of both centrality and density; 2) niche themes, defined by high density and low centrality; 3) emerging or declining themes, featured by low value of both centrality and density; and 4) basic themes, distinguished by high centrality and low density. The motor themes (i.e., the main topics in cyclist safety field) crash severity and bike network were further explored. The research findings will be useful to develop strategies for making bike a safer and more confident form of transport as well as to guide researchers towards the future scientific knowledge.
    Keywords:  Active travel; Bibliometric analysis; Bibliometrix; Cyclist safety; Systematic literature review; Vulnerable road users
    DOI:  https://doi.org/10.1016/j.aap.2023.106996
  35. Stem Cell Res. 2023 Feb 13. pii: S1873-5061(23)00030-2. [Epub ahead of print]67 103044
      Stem cell therapy has been increasingly investigated as a promising strategy for intervertebral disc degeneration (IDD). However, no international analysis of stem cell research has yet been conducted. This study aimed to analyze the major characteristics of published reports of stem cell use for IDD and to present a global insight into stem cell research. The study period spanned from the inception of the Web of Science database to 2021. A search strategy using specific keywords was implemented to retrieve relevant publications. The numbers of documents, citations, countries, journals, article types, and stem cell types were evaluated. A total of 1170 papers were retrieved. The analysis showed a significant increase in the number of papers over time (p < 0.001). High-income economies accounted for the majority of papers (758, 64.79 %). China produced the most articles (378, 32.31 %), followed by the United States (259, 22.14 %), Switzerland (69, 5.90 %), United Kingdom (54, 4.62 %), and Japan (47, 4.02 %). The United States ranked first in terms of the number of citations (10,346), followed by China (9177) and Japan (3522). Japan ranked first in terms of the number of citations per paper (74.94), followed by United Kingdom (58.54) and Canada (53.74). When standardized by population, Switzerland ranked first, followed by Ireland and Sweden. When gross domestic product was considered, Switzerland ranked first, followed by Portugal and Ireland. The number of papers was positively correlated with gross domestic product (p < 0.001, r = 0.673); however, there was no significant correlation with population (p = 0.062, r = 0.294). Mesenchymal stem cells were the most investigated stem cells, followed by nucleus pulposus-derived stem cells and adipose-derived stem cells. A sharp increase in stem cell research was observed in the field of IDD. China produced the most, although several European countries were more productive relative to their populations and economies.
    DOI:  https://doi.org/10.1016/j.scr.2023.103044
  36. Rev Med Inst Mex Seguro Soc. 2022 Dec 19. 60(Suppl 2): 77-85
       Background: Since the beginning of the pandemic, new knowledge about COVID-19 obtained by research has been disseminated in medical and scientific journals, but the large number of publications that have been generated in such a short time has been impressive.
    Objective: To perform a bibliometric analysis of the published articles in medical-scientific journals carried-out by the Mexican Social Security Institute (IMSS) personnel on COVID-19.
    Material and methods: Systematic review of the literature, identifying the publications included in the PubMed and EMBASE databases, up to September 2022. Articles on COVID-19 were included, in which at least one author had IMSS affiliation; there was no restriction on the type of publication, so original articles, review articles, clinical case reports, etc. were included. The analysis was descriptive.
    Results: 588 abstracts were obtained, of which 533 full length articles met the selection criteria. Most were research articles (48%), followed by review articles. Mainly clinical or epidemiological aspects were addressed. They were published in 232 different journals, with a predominance of foreign journals (91.8%). Around half of the publications were carried out by IMSS personnel together with authors from other institutions, national or foreign.
    Conclusions: The scientific contributions prepared by IMSS personnel have contributed to understanding clinical, epidemiological and basic aspects of COVID-19, which has had an impact on improving the quality of care for its beneficiaries.
    Keywords:  Bibliometrics; Coronavirus Infections; Information Management; Publications
  37. Environ Dev Sustain. 2023 Feb 09. 1-18
      The growing concern about climate change necessitates the development of models for long-term measurements of the sustainability performance. The Global Reporting Initiative suggests a framework for sustainability reporting. This study intends to fill two gaps in the existing literature. On the one hand, it assesses the Global Reports Initiative's impact on academics. This article, on the other hand, will compare public policies aimed at a Global Reporting Initiative in rich and developing countries from 1999 to 2020. The above research utilizes bibliometric analysis via Biblioshiny and the Scopus publications database, as well as an online interface for Bibliometrix analysis. For studying the Global Reports Initiative literature, this method offers a viable alternative to traditional bibliometric analysis. This is one of the first studies to use a computer approach to examine the literary paths of the Global Reporting Initiative issue. Among the findings we can mention that, the most GRI inquiries were distributed by the "Journal of Cleaner Production." The most useful GRI creators are Clarkson PM., Azapagic A., and Milne MJ. The findings of this paper suggest that the composition of the GRI addresses one of the keys to global monetary advancement, particularly in developing countries, for the foreseeable future. Our paper indicates that the Global Reporting Initiative principles have a strong potential to handle these connected issues in managing and maintaining the environment by adapting developed-country experiences to developing-country challenges.
    Keywords:  Bibliometric analysis; Global Reporting Initiative; Sustainability
    DOI:  https://doi.org/10.1007/s10668-023-02974-y
  38. Aesthetic Plast Surg. 2023 Feb 13.
      There are few data in the literature evaluating the quality of systematic reviews in breast plastic surgery. This study aimed to evaluate the quality of SR in breast plastic surgery. This is a secondary, observational and analytical study. SR studies on breast plastic surgery, published until 2020, were included. The search for articles was performed in the CCTR, LILACS, MEDLINE and SCIELO databases. After selection and full reading of the studies, they were evaluated according to the AMSTAR-2 instrument. The search identified 810 references, among which 583 did not meet the eligibility criteria, and 227 studies were evaluated. The median publication time of the articles was 57.0 ± 59.0 months, the average impact factor was 0.65 citations per month, and the AMSTAR-2 score was 66.2 ± 32.3. Among the articles evaluated, 39.65% performed a meta-analysis, 52.42% used PRISMA, and most articles pointed out the need for further studies to answer their proposed question (92.95%). Articles that used PRISMA had shorter publication times (39.0 ± 34.0 months) and higher AMSTAR-2 scores (77.6 ± 17.7). An increase in the number of publications and a tendency to increase the AMSTAR-2 score and decrease the impact factor of the article were observed (p < 0.001). In conclusion, the quality of SR in breast plastic surgery has been improving over the years; however, improved methodology and the development of randomized clinical trials are still needed to serve as a basis for SR.Level of Evidence III This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
    Keywords:  AMSTAR; Evidence-based medicine; Individual care; Patient
    DOI:  https://doi.org/10.1007/s00266-023-03264-8
  39. Soc Sci Med. 2023 Feb 03. pii: S0277-9536(23)00118-1. [Epub ahead of print]320 115761
       RATIONALE: The SARS-CoV2 pandemic led to drastic social restrictions globally. Early data suggest that women in science have been more adversely affected by these lockdowns than men, with relatively fewer scientific articles authored by women. However, these observations test broad populations with many potential causes of disparity. Australia presents a natural experimental condition where several states of similar demographics and disease impact had differing approaches in their social isolation strategies. The state of Victoria experienced 280 days of lockdowns from 2020 to 2021, whereas the comparable state of New South Wales experienced 107 days, most of these in 2021, and other states even fewer restrictions.
    OBJECTIVE AND METHODS: To assess how the gender balance changed in Australian biomedical publishing with the lockdowns, we created a custom workflow to analyse PubMed data from more than 120,000 published articles submitted in 2019-2021 from Australian authors.
    RESULTS: Broadly, Australian women have been incredibly resilient to the challenges faced by the lockdowns. There was an increase in the number of published articles submitted in 2020 that was equally due to women as men, including from Victoria. On the other hand, articles specifically addressing COVID-19 were significantly less likely to be authored by women than those on other topics, a finding not likely due to particular gender imbalance in virology or viral epidemiology, since publications on HIV followed similar patterns to previous years. By 2021, this imbalance had reversed, with more COVID-19-related papers authored by women than men.
    CONCLUSIONS: These data suggest women from Victoria were less able to rapidly transition to new research early in the pandemic but had accommodated to the new conditions by 2021. This work indicates we need strategies to support women in science as the pandemic continues and to continue to monitor the situation for its impact on vulnerable groups.
    Keywords:  COVID-19; Female; Gender; Productivity; Publishing; R; SARS-CoV2; Women
    DOI:  https://doi.org/10.1016/j.socscimed.2023.115761
  40. Educ Inf Technol (Dordr). 2023 Feb 07. 1-28
      This study performed a scoping review of the literature concerning the use of technology in mathematics education published between January 1981 and March 2022 to explore research trends. After the defined filtering process, we retrieved 2,433 articles from Web of Science, ERIC, and PsycInfo databases and employed Latent Dirichlet Allocation (LDA) topic modeling to extract key terms and topics from the selected articles. The analysis focused on the four aspects: (a) evolution of research trends of technology use in mathematics education, (b) frequently used words, (c) latent research topics, and (d) research trends for particular topics. The findings revealed a steady increase in research interest, and the combination of frequently used words in the article abstracts suggests popular research topics that have been studied during the set period. The results of LDA identified seven research topics that were not precisely aligned with those identified in prior studies on mathematics education or educational technology. This implied technology integration into mathematics education as a distinctive research area. Over time, the seven topics showed different research trends (stable, fluctuating, increasing, and decreasing). We discussed plausible reasons for these varied patterns and proposed implications based on the research findings.
    Keywords:  Latent Dirichlet Allocation; Research trends; Scoping review; Technology use in mathematics education; Topic modeling
    DOI:  https://doi.org/10.1007/s10639-023-11603-0
  41. Front Psychiatry. 2023 ;14 1116369
      Developmental coordination disorder (DCD) is a motor development disorder that affects an individual's growth and development, and may persist throughout life. It is not caused by intellectual or physical disability. Studies have suggested DCD often occurs in childhood, resulting in a series of abnormal manifestations that hinder children's normal development; cohort studies suggest a higher incidence in boys than in girls. Early diagnosis and appropriate interventions can help relieve symptoms. Unfortunately, the relevant research still needs to be further developed. In this paper, we first start from the definition of DCD, systematically investigate the relevant research papers in the past decades and summarize the current research hotspots and research trends in this field. After summarizing, it is found that this research field has attracted more researchers to join, the number of papers published has increased year by year and has become a hot spot in multidisciplinary research, such as education, psychology, sports rehabilitation, neurobiology, and neuroimaging. The continuous development of the correlation between perinatal factors and DCD, various omics studies, and neuroimaging methods also brings new perspectives and working targets to DCD research. DCD-related research will continue to deepen along the research direction of multivariate, multidimensional, and multimodal.
    Keywords:  bibliometrics; cluster analysis; developmental coordination disorders; neuroimaging; visual analysis
    DOI:  https://doi.org/10.3389/fpsyt.2023.1116369
  42. J Pediatr Surg. 2023 Jan 20. pii: S0022-3468(23)00061-1. [Epub ahead of print]
       BACKGROUND: Surgical disciplines lag behind non-surgical disciplines in attracting female trainees. Female representation of Canadian General Surgeons has not been evaluated in recent years in the literature. The objectives of this study were to assess gender trends in applicants to Canadian General Surgery residency programs and practicing general surgeons and subspecialists.
    METHODS: This retrospective cross-sectional study analyzed gender data for residency applicants ranking General Surgery as their first-choice discipline from publicly-available annual Canadian Residency Matching Service (CaRMS) R-1 match reports from 1998 to 2021. Aggregate gender data for practicing female physicians in General Surgery and related subspecialties, including Pediatric Surgery, obtained from annual Canadian Medical Association (CMA) census from 2000 to 2019 was also analysed.
    RESULTS: There was a significant increase in the proportion of female applicants from 34% in 1998 to 67% in 2021 (p < 0.001) and of successfully matched candidates from 39% to 68% (p = 0.002) from 1998 to 2021. Success rates between male and female candidates were significantly different in 1998 (p < 0.001), but not in 2021 (p = 0.29). The proportion of practicing female General Surgeons also significantly increased from 10.1% in 2000 to 27.9% in 2019 (p = 0.0013), with variable trends in subspecialties.
    CONCLUSION: Gender inequality in General Surgery residency matches has normalized since 1998. Despite females representing more than 40% of applicants and successfully matched candidates to General Surgery since 2008, a gender gap still exists amongst practicing General Surgeons and subspecialists. This suggests the need for further cultural and systemic change to mitigate gender disparities.
    TYPE OF STUDY: Original research article, clinical research.
    LEVEL OF EVIDENCE: Level III (Retrospective cross-sectional study).
    Keywords:  Academic surgery; CaRMS; EDI; Gender in surgery; General surgery; Surgical education; Surgical training; Women in surgery
    DOI:  https://doi.org/10.1016/j.jpedsurg.2023.01.042
  43. Drug Des Devel Ther. 2023 ;17 341-361
       Background: Adaptogens are a class of medicinal plants that can nonspecifically enhance human resistance. Most of the plant adaptogens have relevant applications in dermatology, but there are still few studies related to their particular action and co-operative mechanisms in topical skin application.
    Methods: Plant adaptogens related articles and reviews that published between 1999 and 2022 were obtained from the Web of Science Core Collection database. Various bibliographic elements were collected, including the annual number of publications, countries/regions, and keywords. CiteSpace, a scientometric software, was used to conduct bibliometric analyses. Also, the patsnap global patent database was used to analyze the patent situation of plant adaptogens in the field of cosmetics up to 2021.
    Results: We found that the effects of plant adaptogens on skin diseases mainly involve atopic dermatitis, acne, allergic contact dermatitis, psoriasis, eczema, and androgenetic alopecia, etc. And the effects on skin health mainly involve anti-aging and anti-photoaging, anti-bacterial and anti-fungal, anti-inflammatory, whitening, and anti-hair loss, etc. Also, based on the results of patent analysis, it is found that the effects of plant adaptogens on skin mainly focus on aging retardation. The dermatological effects of plant adaptogens are mainly from Fabaceae Lindl., Araliaceae Juss. and Lamiaceae Martinov., and their mainly efficacy phytochemical components are terpenoids, phenolic compounds and flavonoids.
    Conclusion: The plant adaptogens can repair the skin barrier and maintain skin homeostasis by regulating the skin HPA-like axis, influencing the oxidative stress pathway to inhibit inflammation, and regulating the extracellular matrix (ECM) components to maintain a dynamic equilibrium, ultimately achieving the treatment of skin diseases and the maintenance of a healthy state.
    Keywords:  ECMs; dermatology; pharmacophylogeny; plant adaptogens; skin HPA-like axis; skin homeostasis
    DOI:  https://doi.org/10.2147/DDDT.S395256
  44. Lakartidningen. 2023 Feb 15. pii: 22126. [Epub ahead of print]120
      To secure high-quality education for healthcare professionals, the teaching and learning processes-the "how" in education-should be informed by a research base. Although Swedish medical education research is growing, it lacks a national strategy. This study analysed and compared Swedish and Dutch production of medical education articles over ten years in nine core journals, including the number of editorial board members.  During the period 2012-2021, Swedish authors produced 217 articles, whereas Dutch authors published 1,441. The journals had 466 board members, of which 31 (7%) were Dutch and four (<1%) Swedish. The results show that medical education in Swedish medical faculties requires improvement. To ensure high-quality education opportunities, we propose a national effort to strengthen the educational research base, using the Dutch effort as inspiration.