bims-evares Biomed News
on Evaluation of research
Issue of 2022‒12‒11
sixty-six papers selected by
Thomas Krichel
Open Library Society


  1. Front Oncol. 2022 ;12 1044830
      Background: Bladder cancer is one of the most common urological cancers. Non-muscle invasive bladder cancer (NMIBC) accounts for about 75-85% of all newly diagnosed bladder cancers. Globally, there are many NMIBC-related publications. However, a bibliometric analysis of these publications has not been performed.Objective: This study aims to systematically analyze and visualize NMIBC-related publications through bibliometrics, and to reveal identified topics, hotspots, and knowledge gaps in related fields.
    Methods: Based on the Web of Science core collection database, we firstly analyzed the quantity and quality of publications in the field of NMIBC, secondly profiled the publishing groups in terms of country, institution, author's publication and cooperation network, and finally sorted out and summarized the hot topics of research.
    Results: This bibliometric analysis was conducted from 2001 to 2022. The analysis identified 2,185 articles and reviews, which were published in 402 journals. The number of publications and citations on NMIBC-related research has steadily increased over the last two decades. Furthermore, academic institutions in Europe and the United States play a leading role in NMIBC research. The country, institution, journal, and author with the most publications were the United States (559), Radboud University Nijmegen (88), Urologic oncology: Seminars and Original Investigations (141), and Witjes J (74), respectively. The most frequently used keywords were Bladder cancer (793), Recurrence (671), Urothelial carcinoma (593), Progression (523), Bacillus-calmette-guerin (411), Transitional-cell carcinoma (401), Carcinoma (366), Risk (297), Transurethral resection (286), and Non-muscle-invasive bladder cancer (280).
    Conclusion: More and more scholars are devoted to the research of related NMIBC. This bibliometric analysis revealed that the main research topics and hotspots in NMIBC included pathological staging, clinical diagnosis and treatment, and bladder perfusion.
    Keywords:  bibliometrics; data visualization; hotspots; non-muscle invasive bladder cancer; research status
    DOI:  https://doi.org/10.3389/fonc.2022.1044830
  2. Front Vet Sci. 2022 ;9 1027453
      Introduction: Studies on intracranial aneurysms (IAs) using animal models have evolved for decades. This study aimed to analyze major contributors and trends in IA-related animal research using bibliometric analysis.Methods: IA-related animal studies were retrieved from the Web of Science database. Microsoft Excel 2010, GraphPad Prism 6, VOSviewer, and CiteSpace were used to collect and analyze the characteristics of this field.
    Results: A total of 273 publications were retrieved. All publications were published between 1976 and 2021, and the peak publication year is 2019. Rat model were used in most of the publications, followed by mice and rabbits. Japan (35.5%), the United States (30.0%), and China (20.1%) were the top three most prolific countries. Although China ranks third in the number of publications, it still lacks high-quality articles and influential institutions. Stroke was the most prolific journal that accepted publications related to IA research using animal models. Circulation has the highest impact factor with IA-related animal studies. Hashimoto N contributed the largest number of articles. Meng hui journal published the first and second highest cited publications. The keywords "subarachnoid hemorrhage," "macrophage," "rupture," "mice," "elastase," "gene," "protein," "proliferation," and "risk factors" might be a new trend for studying IA-related animal research.
    Conclusions: Japan and the Unites States contributed the most to IA-related animal studies, in terms of both researchers and institutions. Although China ranks third in terms of the number of publications, it should strengthen the quality of its publications. Researchers should pay attention to the latest progress of Stroke, Journal of Neurosurgery, Neurosurgery, and Circulation for their high-quality IA-related animal studies. Using animal IA models, especially mice, to investigate the molecular mechanisms of IA may be the frontier topic now and in future.
    Keywords:  CiteSpace; VOSviewer; animal model; bibliometrics; intracranial aneurysms (IAs); keyword co-occurrence analysis
    DOI:  https://doi.org/10.3389/fvets.2022.1027453
  3. World Neurosurg. 2022 Dec 03. pii: S1878-8750(22)01687-4. [Epub ahead of print]
      OBJECTIVE: Aneurysms located on the middle cerebral artery (MCA) range from 22% to 31.5% in prevalence of all aneurysms in anterior cerebral circulation. This bibliometric analysis summarizes the most-cited articles on MCA aneurysms and highlights the landmark publications that contributed to today's evidence-based practice.METHODS: In the execution of this bibliometric-based review article, the Scopus database was used to perform a title-specific, keyword-based search for all publications until August 2022. The keyword "(middle cerebral artery OR MCA) AND aneurysm" was used. Our results were arranged in descending order based on the article's citation count. The 100 most-cited articles were selected for analysis. Parameters included the following: title, citation count, citations per year, authors, specialty of first author, institution, country of origin, publishing journal, Source Normalized Impact Per Paper (SNIP), and Hirsch index were collected.
    RESULTS: The keyword-based search showed that 1206 articles were published up to August 2022 on MCA Aneurysms. The top 100 articles were published between 1940 and 2019. The top 100 most cited articles collected a total of 6232 citations with an average of 62.3 citations per paper. The rate of self-citations accounted for an average of 5.75% of the total number of citations.
    CONCLUSION: The bibliometric analysis provides a quantitative overview of how medical literature and interventions are analyzed in academic medicine. In the present study, we evaluated the global trends in research regarding MCA aneurysms by finding the top 100 most cited papers.
    Keywords:  aneurysm; bibliometric; middle cerebral artery; neurosurgery
    DOI:  https://doi.org/10.1016/j.wneu.2022.11.135
  4. Medicine (Baltimore). 2022 Dec 02. 101(48): e32101
      BACKGROUND: More than 400 articles with the title of 100 top-cited articles (Top100) have been published in PubMed. It is unknown whether their citations are fewer (or more) than those found in other bibliometric studies (Nontop100). After determining article themes using coword analysis, a temporal bubble graph (TBG) was used to verify the hypothesis that the Top100 had fewer citations than the Nontop100.METHODS: Using the Web of Science core collection, the top 50 most cited articles were compiled by Top100 and Nontop100, respectively, based on the research area of biomedicine and bibliometrics only. Coword analysis was used to extract themes. The study results were displayed using 6 different visualizations, including charts with bars, pyramids, forests, clusters, chords, and bubbles. Mean citations were compared between Top100 and Nontop100 using the bootstrapping method.
    RESULTS: There were 18 citations in total for the 2 sets of the 50 most cited articles (range 1-134; 5 and 26.5 for Top100 and Nontop100, respectively). A significant difference in mean citations was observed between the 2 groups of Top100 and Nontop100 based on the bootstrapping method (3, 95% confidence interval: [1.18, 4.82]; 26.5, 95% confidence interval: [23.82, 29.18], P < .001). The 11 themes were clustered using coword analysis and applied to a TBG, which is composed of 4 dimensions: themes, years, citations and groups of articles. Among the 2 groups, the majority of articles were published in the journal of Medicine (Baltimore), with 9 and 7, respectively.
    CONCLUSION: Eleven themes were identified as a result of this study. In addition, it reveals distinct differences between the 2 groups of Top100 and Nontop100, with the former containing more recently published articles and the latter containing more citations for articles. Clinical and research clinicians and researchers can use bibliometric analysis to appraise published literature and to understand the scientific landmark using TBG in bibliometrics.
    DOI:  https://doi.org/10.1097/MD.0000000000032101
  5. Front Public Health. 2022 ;10 1040176
      Background: Tuberculosis is a communicable disease that is a major cause of ill health. Bibliometrics is an important statistical methodology used to analyze articles and other publications in the literature study. In this study, publications on molecular epidemiology were analyzed using bibliometric analysis. The statistical analysis of influential publications, journals, countries and authors was first conducted.Methods: The Web of Science database was searched for publications on the molecular epidemiology of tuberculosis with the keywords "tuberculosis" and "molecular epidemiology" in the title. The number of publications, citation analysis, co-authorship of the author, institution and country, keyword co-occurrence, and reference co-citations were analyzed.
    Results: A total of 225 journal articles were retrieved. The mean citation was 37.72 per article and 292.69 per year. The annual publications on molecular epidemiology fluctuated within a certain range in the past. Journal of Clinical Microbiology is the most published journal with 33 articles. RASTOGI N is the most prolific author with 11 articles. The top 1 research institution is Inst Pasteur Guadeloupe. Stratified by the number of publications, the USA was the most prolific country. It also cooperates closely with other countries. Burstness analysis of references and keywords showed that the developing research trends in this field mainly focused on "genetic diversity" and "lineage" during the past decade.
    Conclusion: The annual publications on tuberculosis molecular epidemiology fluctuated within a specific range in the past decade. The USA continues to dominate research output and funding. The exchange of expertise, ideas, and technology is of paramount importance in this field. More frequent and deeper cooperation among countries or institutions will be essential in the future.
    Keywords:  CiteSpace; Web of Science; bibliometrics; molecular epidemiology; tuberculosis
    DOI:  https://doi.org/10.3389/fpubh.2022.1040176
  6. Front Psychol. 2022 ;13 1071121
      Research on metaphor has gained increasing attention of world's scholars since the publication of Lakoff and Johnson's collaborated book Metaphors We Live By in 1980. The present study comprises a pioneering review of publications on Conceptual Metaphor Theory (CMT). It aimed to use the CiteSpace software to provide a clear overview of international research in relation to CMT. In total, 4,458 bibliometric recordings ranging from 1980 to 2022 were collected from the Web of Science (WOS) Core Collection. The descriptive analysis presents the trend of annual publications, the top 10 most prolific journals and the top 10 most productive authors. A document co-citation analysis was conducted via CiteSpace to navigate the key documents in this field. A visualization of keywords and its cluster analysis were conducted to show the research fields and dominant topics. The top 5 keywords with high frequency were language, comprehension, conceptual metaphor, discourse, and figurative language. The most prominent 5 clusters are labeled as right hemisphere, self, time, teacher education, and corpus linguistics. The present review through CiteSpace flags the need for more investigations of CMT from more aspects or interdisciplinary studies, such as metaphor translation, metaphor in literature, metaphor and corpus linguistics, etc.
    Keywords:  CiteSpace; Conceptual Metaphor Theory; bibliometric analysis; hot topics; research trend
    DOI:  https://doi.org/10.3389/fpsyg.2022.1071121
  7. J Pain Res. 2022 ;15 3711-3728
      Introduction: With the wide acceptance of acupuncture, many papers and guidelines recommend that acupuncture is effective for chronic pain (CP). In this study, we applied bibliometric methods to analyze the current research situation of acupuncture intervention in CP, to gain insight into the current situation and future development trend of this field.Material and Methods: Science Citation Index Expanded was searched for publications related to acupuncture for CP between 1900 and 2022. VOSviewer, CiteSpace and Thomson Data Analyzer were used to analyze the annual publication, authors and cited authors and their countries (regions) and institutions, journals and cited journals, cited references, co-occurrence keywords, burst keywords, and the relevant centrality.
    Results: A total of 1968 papers were retrieved, the annual publications have shown a rapid growth trend in the recent 20 years. The USA (708) and the Kyung Hee University (31) were the most productive country and institution, respectively, while the USA (0.37) and University of Maryland (0.13) had the highest centrality. MacPherson, Hugh published the most papers in this field (29), and Vickers, A J were the most influential author (289 times cited). Journal of Alternative and Complementary Medicine was the most productive journal (92), whereas PAIN was the most influential one (4743 times cited). Breivik, H's (2006) paper had the most citation count (3025), while Furlan's (2005) paper had the highest centrality (0.23). The research focuses in this field mainly include pain, electroacupuncture, Low back pain, Systematic review, Randomized controlled trial etc. Researchers are currently paying more attention to the psychological problems caused by CP.
    Conclusion: The research of acupuncture for CP will be further expanded. International cooperation of this research field needs to be further strengthened. More high-quality designed trials need to be conducted.
    Keywords:  CiteSpace; VOSviewer; acupuncture; bibliometric analysis; chronic pain
    DOI:  https://doi.org/10.2147/JPR.S392796
  8. Curr Probl Cardiol. 2022 Nov 30. pii: S0146-2806(22)00419-4. [Epub ahead of print] 101522
      
    Keywords:  Bibliometric; Countries; Familial Hypercholesterolemia; Scopus; Top Authors; Universities
    DOI:  https://doi.org/10.1016/j.cpcardiol.2022.101522
  9. Rheumatol Int. 2022 Dec 04.
      Enthesitis, a characteristic of spondyloarthritis, has been paid considerable attention by researchers, and numerous enthesitis-related studies have been published in recent years. However, no study has been conducted to analyze enthesitis-related researches with bibliometric methods. This study aimed to provide a broad understanding of enthesitis-related researches and explore the direction of hot topics and future research trends from a bibliometric perspective. The global literatures on enthesitis published from 2012 to 2021 were scanned in the Web of Science Core Collection databases. Visualization and bibliometric analyses were generated by an online bibliometric platform and VOSviewer software to explore the hot topics and research trends. A total of 1,181 documents were included in this study. Publications were mainly from these countries in North America and Western Europe. Among these countries, the United States was the leading country with the maximum publication counts (210), highest h-index (47), and largest collaboration network as of June 29, 2022. The most influential journal and powerful author were Journal of Rheumatology and Professor Mease PJ, respectively. Co-occurrence analysis of keywords identified that "axial spondyloarthritis", "interleukin 23", and "secukinumab" might be the future hotspots. More and more attention had been paid to enthesitis in the past 10 years. Present studies focused on the effect of inflammatory cytokines involved in the pathogenesis and the development of antibodies against these factors. These studies played a key role in understanding the research direction and subsequent management of enthesitis, and helped researchers extract hidden valuable information for further study.
    Keywords:  Bibliometric analysis; Enthesitis; Spondyloarthritis; Visualization
    DOI:  https://doi.org/10.1007/s00296-022-05227-9
  10. Int Wound J. 2022 Dec 08.
      Platelet-rich plasma (PRP) has attracted attention because of its potential to accelerate the wound healing process. However, resources for evaluating research trends in the treatment of wounds with PRP were limited. In this study, we aimed to make a bibliometric analysis of the literature related to PRP in the treatment of wounds and explore the research status, hotspots and frontiers in this field in recent 20 years. Studies about PRP treatment for wounds from 2002 to 2021 were retrieved from the Science Citation Index Expanded (SCI-E) of Web of Science (WOS) database. Visualisation softwares such as VOSviewer and SCImago Graphica, and CiteSpace were used to analyse the research trends and features. A total of 1748 studies were identified in the SCI-Expanded from 2002 to 2021. The number of publications on PRP in the treatment of wounds has shown an increasing trend, from 6 (in 2002) to 228 (in 2021). The papers published in the United States have led in times cited (14637) and H-index (63). Though Italy was slightly lower than China in the number of publications, the H-index and average cited (47, 28.45) were higher than that of China (38, 27.01). The strongest keyword was "fibrin" (strength = 13.07), and the longest burst duration keyword was "thrombin" (began in 2002 and ended in 2014). The largest 10 co-citation clusters are as follows: endothelial cell proliferation (#0), regenerative medicine-associated treatment (#1), diabetic wound healing (#2), autologous derived (#3), platelet-rich fibrin (#4), tissue engineering (#5), regenerative potential (#6), clinical randomised trial (#7), histologic observation (#8), and wound bacteria (#9). The United States has made the most outstanding contribution in this field. Chinese researchers need to enhance the quality of publications further. Wound Repair Regen. is the most noteworthy journal. The mechanism of growth factors of PRP, combination therapy, preparation of PRP, and related clinical trials may be topics that need attention.
    Keywords:  bibliometric analysis; platelet-rich plasma (PRP); ulcer; visualisation; wound
    DOI:  https://doi.org/10.1111/iwj.14047
  11. J Cerebrovasc Endovasc Neurosurg. 2022 Dec 09.
      Bibliometric analysis is of paramount importance in assessing the research impact wherein studies are ranked on the basis of citations received. It also brings out the excellent contribution of authors and journals in adding evidence for future research. This study aimed at evaluating the top 100 most cited articles on anterior communicating artery (ACoA) Aneurysms. Scopus database was searched using title specific search for the aneurysm of ACoA and top 100 most cited articles along with their authors, author IDs, affiliated institutions, countries and funding bodies were identified. Search yielded 841 articles and top 100 articles were identified to include in this analysis which secured 5615 citations. Citations per year was also calculated to minimize the risk of bias. Maximum citations by any article were 242. The United States was the major contributor to the number of articles while Kessler Institute for Rehabilitation became the highest contributing institution. DeLuca J proved to be a pioneer in this specialized area as he penned 6 studies being first author in 4 of them, making him the most frequent author. National Institutes of Health and the U.S. Department of Health and Human Services were the main funding bodies. Subcategory analysis revealed, 50% studies provided evidence for the treatment and the surgical outcome of the aneurysm. Studies like these can aid in better neurological and neurosurgical management in decision making of ACoA aneurysm.
    Keywords:  Anterior communicating artery; Anterior communicating artery (ACoA) aneurysms; Bibliometric analysis
    DOI:  https://doi.org/10.7461/jcen.2022.E2022.01.001
  12. Front Bioeng Biotechnol. 2022 ;10 1067111
      Objective: The aim of tissue engineering (TE) is to replace the damaged tissues or failed organs, or restore their missing functions. The important means to achieve this aim is to integrate biomaterials and life elements. Hydrogels are very attractive biomaterials in the field of TE. In particular, engineering extracellular matrices (ECMs) formed by photosensitive hydrogels have captivated much attention, because photopolymerization has many advantages over traditional polymerization approaches, such as rapidity of reaction, spatiotemporal controllability of polymerization process, and operability at physiological temperature, especially it can realize the fabrications of engineering ECMs in the presence of living cells. There have been many excellent reviews on the applications of photosensitive hydrogels in TE in recent years, however, it is inevitable that researchers may have left out many important facts due to exploring the literature from one or a few aspects. It is also a great challenge for researchers to explore the internal relationships among countries, institutions, authors, and references from a large number of literatures in related fields. Therefore, bibliometrics may be a powerful tool to solve the above problems. A bibliometric and visualized analysis of publications concerning the photosensitive hydrogels for TE applications was performed, and the knowledge domain, research hotspots and frontiers in this topic were identified according to the analysis results. Methods: We identified and retrieved the publications regarding the photosensitive hydrogels for TE applications between 1996 and 2022 from Web of Science Core Collection (WoSCC). Bibliometric and visualized analysis employing CiteSpace software and R-language package Bibliometrix were performed in this study. Results: 778 publications meeting the eligibility criteria were identified and retrieved from WoSCC. Among those, 2844 authors worldwide participated in the studies in this field, accompanied by an average annual article growth rate of 15.35%. The articles were co-authored by 800 institutions from 46 countries/regions, and the United States published the most, followed by China and South Korea. As the two countries that published the most papers, the United States and China could further strengthen cooperation in this field. Univ Colorado published the most articles (n = 150), accounting for 19.28% of the total. The articles were distributed in 112 journals, among which Biomaterials (n = 66) published the most articles, followed by Acta Biomaterialia (n = 54) and Journal of Biomedical Materials Research Part A (n = 42). The top 10 journals published 47.8% of the 778 articles. The most prolific author was Anseth K (n = 33), followed by Khademhosseini A (n = 29) and Bryant S (n = 22). A total of 1443 keywords were extracted from the 778 articles and the keyword with the highest centrality was "extracellular matrix" (centrality: 0.12). The keywords appeared recently with strong citation bursts were "gelatin", "3d printing" and "3d bioprinting", representing the current research hotspots in this field. "Gelma", "3d printing" and "thiol-ene" were the research frontiers in recent years. Conclusion: This bibliometric and visualized study offered a comprehensive understanding of publications regarding the photosensitive hydrogels for TE applications from 1996 to 2022, including the knowledge domain, research hotspots and frontiers in this filed. The outcome of this study would provide insights for scholars in the related research filed.
    Keywords:  bibliometrics; bibliometrix; citespace; photosensitive hydrogels; tissue engineering
    DOI:  https://doi.org/10.3389/fbioe.2022.1067111
  13. Rheumatol Immunol Res. 2021 Dec;2(4): 241-248
      Objectives: The purpose of this study was to identify and analyze the 100 top-cited articles in the field of osteoarthritis (OA) from 1990 to 2020.Methods: We used the Web of Science to retrieve the articles related to OA. Then we selected 100 target articles and manually collected their general information, including article title, author, year of publication, journal, type of article, and the number of citations.
    Results: The 100 top-cited articles were published in the period from 1990 to 2015. These articles have been cited 66,494 times in total, with the highest being 2382 times, the lowest being 433 times, the median number being 613, and a mean of 664.94 times. The 100 top-cited articles appeared in a total of 35 influential journals. The greatest number of articles in the top of 100 was published in Arthritis and Rheumatism. The authors of these articles came from 18 countries, led by the United States (n = 48), followed by the United Kingdom (n = 15). Among all the institutions, Boston University led the list with 10 articles. The most prevalent type of the study was review (n = 38) and clinical study (n = 38), followed by guideline (n = 12), basic science (n = 10) and other types.
    Conclusions: This study provided some insights on the literature development and citation of OA in the recent 30 years. Articles published in high-impact journals are more likely to be cited in the field of OA. As recent studies did not have enough time to accumulate the number of citations, the latest articles may not be included in the top 100 cited articles.
    Keywords:  Top-cited; arthritis; bibliometrics; osteoarthritis
    DOI:  https://doi.org/10.2478/rir-2021-0033
  14. Front Public Health. 2022 ;10 1002015
      Antibiotic-resistant bacteria (ARB) are a serious threat to the health of people and the ecological environment. With this problem becoming more and more serious, more countries made research on the ARB, and the research number has been sharply increased particularly over the past decade. Therefore, it is quite necessary to globally retrace relevant researches on the ARB published from 2010 to 2020. This will help researchers to understand the current research situation, research trends and research hotspots in this field. This paper uses bibliometrics to examine publications in the field of ARB from 2010 to 2020 that were retrieved from the Web of Science (WOS). Our study performed a statistical analysis of the countries, institutions, journals, authors, research areas, author keywords, Essential Science Indicators (ESI) highly cited papers, and ESI hotspots papers to provide an overview of the ARB field as well as research trends, research hotspots, and future research directions in the field. The results showed that the number of related studies is increasing year by year; the USA is most published in the field of ARB; China is the most active in this field in the recent years; the Chinese Acad Sci published the most articles; Sci. Total Environ. published the greatest number of articles; CM Manaia has the most contributions; Environmental Sciences and Ecology is the most popular research area; and "antibiotic resistance," "antibiotics," and "antibiotic resistance genes" were the most frequently occurring author keywords. A citation analysis showed that aquatic environment-related antibiotic resistance is a key research area in this field, while antimicrobial nanomaterial-related research is a recent popular topic.
    Keywords:  antibiotic resistance; antibiotic resistant bacteria; antibiotics; bibliometrics; keyword analysis
    DOI:  https://doi.org/10.3389/fpubh.2022.1002015
  15. Front Oncol. 2022 ;12 983892
      Objectives: The study aims to summarize publication characteristics of anti-programmed cell death protein 1 (PD-1)/programmed cell death 1 ligand 1 (PD-L1) immunotherapy for esophageal cancer and create scientific maps to explore hotspots and emerging trends with bibliometric methods.Methods: The publications between 2012 and 2021 were retrieved from the Web of Science Core Collection (WoSCC) on June 20, 2022. Bibliometric tools including HistCite, VOSviewer, and CiteSpace were used for statistical analysis. Data on the trend of the annual output, countries/regions, institutions, journals, authors, subject categories, keywords, and co-cited references were presented in this study.
    Results: A total of 552 publications written by 3,623 authors of 872 institutions, 44 countries/regions in 250 journals were included in the bibliometric study. China, USA and Japan were the key countries in this field. Kato Ken, Bang Yung-Jue, Frontiers in Oncology, Journal of Clinical Oncology and Natl Canc Ctr were the top 1 productive author, co-cited author, productive journal, co-cited journal and prolific institution, respectively. The top 4 most present keywords were esophageal cancer, immunotherapy, esophageal squamous cell carcinoma and PD-L1. Neoadjuvant chemotherapy, response, PD-1 blockade and CD8+ T cell were four latest research frontiers. The keywords reflected the progress from PD-1/PD-L1 expression to the clinical application of PD-1/PD-L1 inhibitors. The current researches mainly focus on neoadjuvant immunotherapy for esophageal cancer and development of biomarkers. Further research is warranted to determine effective predictive biomarkers or models, illustrate the molecular mechanism of combined treatment, and construct the optimal therapeutic strategy.
    Conclusions: This study visually analyzed the global trend and hotspots of anti-PD-1/PD-L1 immunotherapy for esophageal cancer over the past decade. The results could guide scientists to comprehensively understand the global frontiers and determine future directions.
    Keywords:  CiteSpace; HistCite; VOSviewer; Web of Science (WOS); anti-PD-1/PD-L1; bibliometrics; esophageal cancer; immunotherapy
    DOI:  https://doi.org/10.3389/fonc.2022.983892
  16. Front Psychol. 2022 ;13 1029812
      This paper undertakes a literature review of psychological, Educational Learning Strategies, and Models during the COVID-19 Pandemic. It examines data from 359 publications relating to this subject, published on the Web of Science, Scopus, and ScienceDirect between 2020 and 2021 using bibliometric analysis adapted with VOSviewer software. The review discusses the following approaches (keywords, authors, references (research papers), research work, countries, and research institutions). It concluded that bibliometric analysis is fundamental for detailing the theoretical literature and developing an integrated theoretical framework for psychological and Educational Learning Strategies. The psychological impact on students and potential stress needs to be closely monitored and evaluated, to plan effective policies while adopting these pedagogical approaches.
    Keywords:  COVID-19; VOSviewer; bibliometric analysis; models; psychological and educational learning strategies
    DOI:  https://doi.org/10.3389/fpsyg.2022.1029812
  17. World J Gastroenterol. 2022 Nov 21. 28(43): 6168-6202
      BACKGROUND: Journal Impact Factor™ (JIF) is often used to evaluate the relative reputation and quality of academic journals in their respective fields, and can greatly influence the quality and scope of subsequent manuscript submissions. Therefore, many if not all academic journals are interested in increasing their JIF, to improve their academic impact.AIM: To determine the importance of the integrity of the editorial and publication process in improving the academic influence of academic journals and the JIF of academic journals.
    METHODS: In this paper, we describe our statistical analysis of bibliometric factors - including the 2021 JIFs released in the Journal Citation Report™ 2022, discipline rankings, received and published articles in 2019-2021, and webpage visits and downloads - for seven journals published by Baishideng Publishing Group (Baishideng) and indexed in Science Citation Index Expanded™; ultimately, we introduce and discuss the editing and publishing processes of Baishideng's journals in their entirety, as they form the basis for our objective of safeguarding and bolstering integrity in academic publication.
    RESULTS: For the seven journals assessed, their 2021 JIFs were basically unchanged from 2020, with the current metric ranging from 5.374 for World Journal of Gastroenterology (WJG) to 1.534 for World Journal of Clinical Cases (WJCC). Further assessments of the journals' bibliometrics from 2019 to 2020, showed that World Journal of Stem Cells has the highest self-citation rate (1.43%) and World Journal of Gastrointestinal Surgery has the lowest (0.21%). Additionally, the total 3012 articles published during this period were cited by more than 20000 articles in approximately 8000 academic journals. Of note, the 1102 articles published in WJG were cited by articles in 3059 journals, among which 171 journals have a JIF of > 10, including internationally renowned academic journals such as CA-A Cancer Journal for Clinicians (2021 JIF 286.130, record count: 1), Lancet (2021 JIF 202.731, record count: 4), Nature Reviews Immunology (2021 JIF 108.555, record count: 2), Nature Reviews Gastroenterology & Hepatology (2021 JIF 73.082, record count: 9), Lancet Gastroenterology & Hepatology (2021 JIF 45.042, record count: 8), Gastroenterology (2021 JIF 33.883, record count: 19), and Gut (2021 JIF 31.793, record count: 21). This suggests that Baishideng's journals have been widely recognized for their academic quality. In the Reference Citation Analysis (RCA) database, all seven Baishideng-published journals obtained a 2022 Journal Article Influence Index (JAII). For example, WJG has a 2022 JAII of 22.048, ranking 18th out of 102 journals in the field of gastroenterology & hepatology in the RCA, with 469909 total citations (6/102) and 21313 total articles (5/102). The numbers of manuscripts received and published in 2021 were both higher than those in 2019-2020. For example, WJCC received a total of 3650 manuscripts in 2021, which is 91.1% higher than those in 2019-2020 (average: 1910 papers/year). In 2021, WJCC published 1296 articles, representing an increase of 105.1% compared to those in 2019-2020 (average: 632 articles/year). The numbers of webpage visits and downloads received by the seven journals have increased year by year. For example, the number of total visits received by WJG in 2019-2021 was 1974052 in 2019, 2317835 in 2020 (increased by 17.4% compared with that in 2019), and 2652555 in 2021 (increased by 4.4% compared with that in 2020). The visitors were from more than 220 countries and regions worldwide, such as the United States, China, and the United Kingdom. Open access (OA) plays a vital role in improving the quality, efficiency, transparency, and integrity of academic journal publishing. From 2019 to 2021, a total of 5543 OA articles were published in the seven journals, of which 2083 (37.6%) were invited and published free-of-charge. During the same period, 1683 articles were published in WJG, and the authors were from more than 70 countries and regions. For the total 5543 articles published in the seven journals from 2019 to 2021, 3903 article quality tracking reports were received after the online publication of these articles. The quality of the articles was further evaluated through the Baishideng's article quality and author evaluation tracking system, with 4655 articles (84.0%) having received author evaluation and feedback, which contributes to tracking metrics for authors' satisfaction with the collective publication processes. From March 25, 2021 to June 28, 2022, the seven journals received a total of 424 reader evaluations and 229 letters from readers; this subsequent reader engagement demonstrates that the popularity of the published articles and the volume of their readership audience were improved through the reader evaluation system.
    CONCLUSION: Ultimately, the findings from our bibliometric assessments indicate that establishing, promoting and actively practicing processes that safeguard and bolster the integrity of the editing and publication process also help to improve the academic influence of academic journals, which itself is the cornerstone for improving JIF.
    Keywords:  Academic influence; Academic journal; Editing process; Journal Impact Factor; Language polishing; Open access; Peer review; Publishing process
    DOI:  https://doi.org/10.3748/wjg.v28.i43.6168
  18. World Neurosurg. 2022 Dec 05. pii: S1878-8750(22)01685-0. [Epub ahead of print]
      INTRODUCTION: The first case of coronavirus disease 2019 (COVID-19) was reported in December 2019 in Wuhan, China. This study uses a bibliometric analysis of the top 100 most cited neurosurgical COVID-19-related articles to date to identify and determine their characteristics.METHODS: The Scopus library was searched for all published articles on neurosurgery and COVID-19. The main keywords were used for the search "neurosurgery, neurosurgical, and COVID-19". English language articles reporting on neurosurgical aspects during COVID-19 were included in the study. The retrieved top 100 articles were analyzed, and the following characteristics were noted for each article: 1) article title, 2) year of publication, 3) citations, 4) first author, 5) corresponding author, 6) names of other authors, 7) journal name 8) article type, 9) study focus and 10) involvement of the patient.
    RESULTS: Our search obtained articles published from December 2019 until 29 March 2022. It was observed that 93% of the documents were published in 2020. The top 100 articles have been cited 2649 times in total. The most cited article was "Factors Associated with Surgical Mortality and Complications among Patients with and without Coronavirus Disease 2019 (COVID-19) in Italy" by Doglietto F. et al., published in JAMA Neurology in June 2020, with 124 citations.
    CONCLUSIONS: This analysis facilitated making evidence-based clinical decisions and drawing the attention of researchers to identify and contribute to the increasing scientific work by identifying the top 100 most cited neurosurgical COVID-19-related articles published.
    Keywords:  COVID-19; Coronavirus disease 2019; Neurosurgical; neurological surgery
    DOI:  https://doi.org/10.1016/j.wneu.2022.11.133
  19. J Adv Nurs. 2022 Dec 04.
      AIM: This study aimed to analyse the study focus, thematic trends and evolution of studies on the leadership and care in nursing by using a bibliometric analysis.DESIGN: Descriptive and bibliometric analyses were employed.
    METHODS: The study universe included 3558 articles on the leadership and care in the Web of Science (WoS) database. The data analysis and graphical presentation were conducted using Bibliometrix Package in R software.
    RESULTS: Within the scope of the study, articles published by 10,255 authors in 184 different sources between 1982-2021 were reached. Five thousand eight hundred and twenty-eight author keywords were found in these studies. The most frequent author keywords included "leadership," "nursing," "nurse," "evidence-based practice," "management," "nursing leadership" and "patient safety." It was further suggested that the most frequently used trend topics in early years were "new roles," "faculty practice," "research implementation" while trend topics such as "systematic review," "older adults" and "COVID-19' have become popular in recent years.
    CONCLUSION: The number of studies on the leadership and care in nursing has gradually increased over the years, and this subject has already become an active field of study in nursing research. In addition, nurse-related themes such as job satisfaction, teamwork and retention have been reviewed more intensively while patient-based and fundamental care-based themes have been less studied.
    IMPACT: This study was the first bibliometric analysis to focus on the research focus, thematic trends and evolution of research on the leadership and care in nursing. Only a limited amount of data are available on the current knowledge structure, research focus, thematic trends and evolution of research on leadership and care in nursing. The results of this study may establish a solid ground to design further studies and provide guidance.
    Keywords:  bibliometrics; care; fundamental care; leadership; nurses; nursing
    DOI:  https://doi.org/10.1111/jan.15527
  20. Front Behav Neurosci. 2022 ;16 991805
      Objective: Analyze the research status of Tourette Syndrome (TS) in children by CiteSpace and determine the current research hotspots and frontiers.Materials and methods: We chose publications indexed in the Web of Science Core Collection (WoSCC) database for studies related to TS in children from 2011 to 2021. We built online cooperation maps of countries/regions, institutions, authors, journals, references, and keywords by CiteSpace, and identified hotspots and frontiers of study for children's TS.
    Results: A total of 1,232 publications about TS in children were downloaded from the WoSCC. The USA (414) was the country with the highest rate of production, and University College London (87) was the institution that had the highest publication rate. Andrea Eugenio Cavanna was the most prolific author (39 papers). There was inactive cooperation between institutions, countries/regions, and authors. The Journal of European Child & Adolescent Psychiatry was the most active journal. Hot topics focused on epidemiology, comorbidities, deep brain stimulation, behavioral therapy, basal ganglia, pharmacological treatment, and risk factors of TS in children.
    Conclusion: According to the CiteSpace results, this study found that authors, countries/regions, and institutions were not actively working together. Current research hotspots mainly consist of epidemiology, comorbidities, deep brain stimulation, behavior therapy, and basal ganglia. The main research trends include comorbidities, pharmacological treatment, and risk factors. Therefore, international cooperation should be strengthened in the future, and it should be mindful of the psychiatric comorbidities of TS, the choice of intervention measures, and early warning of risk factors.
    Keywords:  CiteSpace; Tourette syndrome; Web of Science; children; data visualization
    DOI:  https://doi.org/10.3389/fnbeh.2022.991805
  21. Int J Phytoremediation. 2022 Dec 05. 1-15
      Herein, 7,308 relevant documents on biochar application for the remediation of heavy metal (HM)-contaminated soil (BARHMCS) from 1991 to 2020 were extracted from the Web of Science Core Collection and subjected to bibliometric and knowledge mapping analyses to provide a global perspective. The results showed that (1) the number of publications increased over time and could be divided into two subperiods, i.e., the slow growth period (SGP) and rapid growth period (RGP), according to whether the annual publication number was ≥300. (2) A total of 126 countries, 741 institutions, and 1,021 scholars have contributed to this field. (3) These studies are mainly published in Science of the Total Environment, Chemosphere, etc., and are mainly based on the categories of environmental science, soil science, and environmental engineering. (4) The top five keyword clusters for the SGP were biochar, biochar, sorption, charcoal, and HMs, and those for the RGP were adsorption, black carbon, nitrous oxide, cadmium, and pyrolysis. (5) The main knowledge domains and the most cited references during the SGP and RGP were discussed. (6) Future directions are related to biochar application for plant remediation, the mitigation of climate change through increased carbon sequestration, biochar modification, and biochar for HMs and multiple organic pollutants.
    Keywords:  Biochar; CiteSpace; heavy metal-contaminated soil
    DOI:  https://doi.org/10.1080/15226514.2022.2128038
  22. Front Immunol. 2022 ;13 1065724
      Background: There are no guidelines on dietary supplements for the prevention or treatment of COVID-19. Therefore, we would like to analyze and discuss the above confusion through the bibliometric analysis.Methods: On 3 September 2022, we conducted a search of all relevant literature retrieved from the WOS core collection database from 2019 to 2022. CiteSpace software is used to build the visual co-occurrence network.
    Results: In the study of "COVID-19 and Dietary Supplements", the total of 170 authors published 855 articles in 451 journals. Several distinct core author groups were formed by Wang, Grant, Singh, Zhu, and other authors with numerous publications. The majority of the publications came from the Shahid Beheshti University of Medical Sciences. The United States of America had the highest number of publications. By analyzing keyword clusters, we found that the research focus was dietary supplements (vitamin D, vitamin K, vitamin C), mechanisms (ferritin, specialized pro-resolving mediators (SPMs), oxidative stress), research methods (clinical trials), and the prevention and treatment strategies (lockdown) of COVID-19.
    Conclusions: vitamin D is the mainstream dietary supplement for COVID-19. There are still numerous controversies that deserve further discussion. Such as whether the use of vitamin D or TCM offers benefits, and whether the addition of dietary supplements during the lockdown measures can help prevent COVID-19 infection.
    Keywords:  Citespace; bibliometric analysis; coronavirus disease 2019(COVID-19); vitamin C; vitamin D
    DOI:  https://doi.org/10.3389/fimmu.2022.1065724
  23. Front Immunol. 2022 ;13 1047007
      Background: The Brain-Gut Axis, a bidirectional signaling pathway that connects the intestinal and central nervous systems, plays an important role in the development of psychiatric disorders. However, the overall research trends in this field are unclear. This study explored the patterns of research on the brain-gut axis and psychiatric disorders from a bibliometric perspective.Methods: Relevant data were retrieved from the Web of Science Core Collection, with search terms on psychiatric disorders and the brain-gut axis. R (version 4.2.0), VOSviewer (version 1.6.17), CiteSpace software, and the online bibliometric platform were used in the data analysis.
    Results: A total of 2,298 articles published between 1993 and 2022 were identified, showing an increasing trend over time. China (1,859; 20.70%) was the country that contributed the most publications. The journal Nutrients (95; 4.13%) published the most publications. Cryan JF (153; H-index=73) and University College Cork (559; 22.54%) were the most influential author and the most productive institution, respectively. The high-frequency keywords were clustered into six themes, including neurodegenerative diseases, stress-related diseases, immune, brain behavior, depression, and probiotic-related topics; of which, depression (880; 2019), anxiety (207; 2018) and autism (191; 2019) were the most studied psychiatric disorders in the past 5 years. "Depressive symptom" (2019-2020) and "probiotic treatment" (2019-2020) were the main areas addressed in recent years.
    Conclusion: Research on the brain-gut axis and psychiatric disorders has attracted increasing attention in the past decade, with most publications originating from high-income level countries. This study provides a useful perspective on understanding the research trends, key hot topics, and research gaps in this expanding field.
    Keywords:  bibliometric analysis; brain-gut axis; gut microbiota; hotspots; psychiatric disorders
    DOI:  https://doi.org/10.3389/fimmu.2022.1047007
  24. Hum Vaccin Immunother. 2022 Nov 30. 18(6): 2119766
      Vaccination is considered the most effective way to reduce the impact of coronavirus disease 2019 (COVID-19). Several new vaccines have been manufactured. This study aimed to assess the current status and prospects of COVID-19 vaccine research using a bibliometric analysis. We analyzed 3,954 scientific articles on COVID-19 vaccines in the Web of Science Core Collection (WoSCC). CiteSpace and VOSviewer were used for bibliometric visualization. Original articles and reviews were used for the analysis. A total of 2,783 (70.38%) studies were published in 2021. The USA contributed the highest, publishing 1,390 articles with 41,788 citations, followed by China and the UK. The USA's primary collaborators were the UK (n = 133), China (n = 87), and Canada (n = 65). The most active institutions were the University of Oxford and Harvard Medical School, while Emory University was the most influential. The Vaccines journal had the most number of publications (402). The most cited journal was the New England Journal of Medicine. In 2021, the focus was on RNA vaccines, attitudes toward vaccination, and hesitancy. In contrast, studies in 2022 focused on vaccine double-blind trials, viral mutations, and antibodies. In the context of rapid virus transmission, vaccine studies on immunogenicity, spike proteins, efficacy, safety, and antibody response have been prioritized. Additional phased clinical trials are needed to determine the effectiveness, acceptance, and side effects of vaccines against mutated strains of the virus.
    Keywords:  COVID-19; CiteSpace; VOSviewer; Web of Science Core Collection; bibliometric analysis; vaccines
    DOI:  https://doi.org/10.1080/21645515.2022.2119766
  25. Front Aging Neurosci. 2022 ;14 1036120
      Background: Recently, research on the microbiota-gut-brain axis (MGBA) has received increasing attention, and the number of studies related to Alzheimer's disease (AD) has increased rapidly, but there is currently a lack of summary of MGBA in AD.Objective: To capture research hotspots, grasp the context of disciplinary research, and explore future research development directions.
    Methods: In the core dataset of Web of Science, documents are searched according to specific subject words. CiteSpace software is used to perform statistical analysis on measurement indicators such as the number of published papers, publishing countries, institutions, subject areas, authors, cocited journals, and keywords, and to visualize of a network of relevant content elements.
    Results: The research of MGBA in AD has shown an upward trend year by year, and the cooperation between countries is relatively close, and mainly involves the intersection of neuroscience, pharmacy, and microbiology. This research focuses on the relationship between MGBA and AD symptoms. Keyword hotspots are closely related to new technologies. Alzheimer's disease, anterior cingulate cortex, inflammatory degeneration, dysbiosis, and other research are the focus of this field.
    Conclusion: The study revealed that the research and development of MGBA in AD rapidly progressed, but no breakthrough has been made in the past decade, it still needs to be closely combined with multidisciplinary technology to grasp the frontier hotspots. Countries should further strengthen cooperation, improve the disciplinary system, and increase the proportion of empirical research in all research.
    Keywords:  Alzheimer’s disease; CiteSpace; Web of Science database; bibliometric analysis; microbiota; microbiota-gut-brain axis; research trends
    DOI:  https://doi.org/10.3389/fnagi.2022.1036120
  26. Front Neurosci. 2022 ;16 1048565
      Background: Scholars have long understood that gastrointestinal microorganisms are intimately related to human disorders. The literature on research involving the gut microbiome and neuroscience is emerging. This study exposed the connections between gut microbiota and neuroscience methodically and intuitively using bibliometrics and visualization. This study's objectives were to summarize the knowledge structure and identify emerging trends and potential hotspots in this field.Materials and methods: On October 18, 2022, a literature search was conducted utilizing the Web of Science Core Collection (WoSCC) database for studies on gut microbiota and neuroscience studies from 2002 to 2022 (August 20, 2022). VOSviewer and CiteSpace V software was used to conduct the bibliometrics and visualization analysis.
    Results: From 2002 to 2022 (August 20, 2022), 2,275 publications in the WoSCC database satisfied the criteria. The annual volume of publications has rapidly emerged in recent years (2016-2022). The most productive nation (n = 732, 32.18%) and the hub of inter-country cooperation (links: 38) were the United States. University College Cork had the most research papers published in this area, followed by McMaster University and Harvard Medical School. Cryan JF, Dinan TG, and Clarke G were key researchers with considerable academic influence. The journals with the most publications are "Neurogastroenterology and Motility" and "Brain Behavior and Immunity." The most cited article and co-cited reference was Cryan JF's 2012 article on the impact of gut microbiota on the brain and behavior. The current research hotspot includes gastrointestinal microbiome, inflammation, gut-brain axis, Parkinson's disease (PD), and Alzheimer's disease (AD). The research focus would be on the "gastrointestinal microbiome, inflammation: a link between obesity, insulin resistance, and cognition" and "the role of two important theories of the gut-brain axis and microbial-gut-brain axis in diseases." Burst detection analysis showed that schizophrenia, pathology, and psychiatric disorder may continue to be the research frontiers.
    Conclusion: Research on "gastrointestinal microbiome, inflammation: a link between obesity, insulin resistance, and cognition" and "the role of two important theories of the gut-brain axis and microbial-gut-brain axis in diseases" will continue to be the hotspot. Schizophrenia and psychiatric disorder will be the key research diseases in the field of gut microbiota and neuroscience, and pathology is the key research content, which is worthy of scholars' attention.
    Keywords:  WoSCC; bibliometric; gastrointestinal microbiome; hotspots; neuroscience; research trends; visualization analysis
    DOI:  https://doi.org/10.3389/fnins.2022.1048565
  27. J Agric Food Chem. 2022 Dec 05.
      3-Monochloropropane-1,2-diol esters (3-MCPDE) are common food contaminants mainly formed in the edible oil refining process. Due to their potential hazards, 3-MCPDE has become a widespread food safety concern. In this study, CiteSpace and VOSviewer were used to conduct a bibliometric analysis on the 3-MCPDE research papers collected in the Web of Science Core Collection from 1998 to 2022. The results showed that the number of research publications on 3-MCPDE has increased rapidly since 2010. Analysis of the hotspots in 3-MCPDE studies showed that more attention has been paid to the exposure assessment, formation mechanism, detection methods, mitigation methods and toxicity, and toxicology of 3-MCPDE. Finally, the future trends of research on 3-MCPDE were analyzed and proposed. The mitigation methods and toxicology studies of 3-MCPDE are still the research hotspots in the future. In addition, nutritional intervention for 3-MCPDE toxicity will be an emerging trend.
    Keywords:  3-MCPDE; CiteSpace; VOSviewer; bibliometric analysis; research hotspots; research trends
    DOI:  https://doi.org/10.1021/acs.jafc.2c06067
  28. Neurosci Biobehav Rev. 2022 Dec 01. pii: S0149-7634(22)00468-7. [Epub ahead of print]144 104979
      Research on negative symptoms of schizophrenia has received renewed interest since the 1980s. A scientometric analysis that objectively maps scientific knowledge, with changes in recent trends, is currently lacking. We searched the Web of Science Core Collection (WOSCC) on December 17, 2021 using relevant keywords. R-bibliometrix and CiteSpace were used to perform the analysis. We retrieved 27,568 references published between 1966 and 2022. An exponential rise in scientific interest was observed, with an average annual growth rate in publications of 16.56% from 1990 to 2010. The co-cited reference network that was retrieved presented 24 different clusters with a well-structured network (Q=0.7921; S=0.9016). Two distinct major research trends were identified: research on the conceptualization and treatment of negative symptoms. The latest trends in research on negative symptoms include evidence synthesis, nonpharmacological treatments, and computational psychiatry. Scientometric analyses provide a useful summary of changes in negative symptom research across time by identifying intellectual turning point papers and emerging trends. These results will be informative for systematic reviews, meta-analyses, and generating novel hypotheses.
    Keywords:  Alogia; Anhedonia; Asociality; Avolition; Bibliometric; Blunted affect; Network; Psychosis
    DOI:  https://doi.org/10.1016/j.neubiorev.2022.104979
  29. Inflamm Regen. 2022 Dec 07. 42(1): 60
      BACKGROUND: Axons play an essential role in the connection of the nervous system with the rest of the body. Axon lesions often lead to permanent impairment of motor and cognitive functions and the interaction with the outside world. Studies focusing on axon regeneration have become a research field with considerable interest. The purpose of this study is to obtain an overall perspective of the research field of axonal regeneration and to assist the researchers and the funding agencies to better know the areas of greatest research opportunities.METHODS: We conducted a bibliometric analysis and Latent Dirichlet Allocation (LDA) analysis of the global literature on axon regeneration based on the Web of Science (WoS) over the recent 22 years, to address the research hotspots, publication trends, and understudied areas.
    RESULTS: A total of 21,018 articles were included, which in the recent two decades has increased by 125%. Among the top 12 hotspots, the annual productions rapidly increased in some topics, including axonal regeneration signaling pathway, axon guidance cues, neural circuits and functional recovery, nerve conduits, and cells transplant. Comparatively, the number of studies on axon regeneration inhibitors decreased. As for the topics focusing on nerve graft and transplantation, the annual number of papers tended to be relatively stable. Nevertheless, the underlying mechanisms of axon regrowth have not been completely uncovered. A lack of notable research on the epigenetic programs and noncoding RNAs regulation was observed. The significance of cell-type-specific data has been highlighted but with limited research working on that. Functional recovery from neuropathies also needs further studies.
    CONCLUSION: The last two decades witnessed tremendous progress in the field of axon regeneration. There are still a lot of challenges to be tackled in translating these technologies into clinical practice.
    Keywords:  Axon regeneration; Bibliometric analysis; Extrinsic environment; Latent Dirichlet Allocation analysis; Multifactor regulations; Neuronal intrinsic pathways
    DOI:  https://doi.org/10.1186/s41232-022-00244-4
  30. Front Med (Lausanne). 2022 ;9 980684
      Background: Patient safety gained public notoriety following the 1999 report of the Institute of Medicine: To Err is Human - Building a Safer Health System which summarized a culminated decades' worth of research that had so far been largely ignored. The aim of this study was to analyze the report's impact on patient safety research in anesthesiology.Methods: A bibliometric analysis was performed on all anesthesiologic publications from 2000 to 2019 that referenced To Err Is Human. In bibliometric literature, references are understood to represent an author's conscious decision to express a relationship between his own manuscript and the cited document.
    Results: The anesthesiologic data base contained 1.036 publications. The journal with the most references to the IOM report is Anesthesia & Analgesia. By analyzing author keywords and patterns of collaboration, changes in the patient safety debate and its core themes in anesthesiology over time could be visualized. The generic notion of "error," while initially a central topic in the scientific discourse, was subsequently replaced by terms representing a more granular, team-oriented, and educational approach. Patient safety research in anesthesia, while profiting from a certain intellectual and conceptual head start, showed a discursive shift toward more managerial, quality-management related topics as observed in the health care system as a whole.
    Conclusions: Over the last 20 years, the research context expanded from the initial focus set forth by the IOM report, which ultimately led to an underrepresentation of research on critical incident reporting and systemic approaches to safety. Important collaborations with safety researchers from outside of health care dating back to the 1990's were gradually reduced, while previous research within anesthesiology was aligned with a broader, more managerial patient safety agenda.
    Keywords:  anesthesiology; bibliometric analysis; bibliometrics; human factors; patient safety; safety; safety research
    DOI:  https://doi.org/10.3389/fmed.2022.980684
  31. JAMA Netw Open. 2022 Dec 01. 5(12): e2245590
      Importance: Both citation and funding metrics converge in shaping current perceptions of academic success.Objective: To evaluate what proportion of the most-cited US-based scientists are funded by biomedical federal agencies and whether funded scientists are more cited than nonfunded ones.
    Design, Setting, and Participants: This survey study used linkage of a Scopus-based database on top-cited US researchers (according to a composite citation metric) and the National Institutes of Health RePORTER database of federal funding (33 biomedical federal agencies). Matching was based on name and institution. US-based top-cited scientists who were allocated to any of 69 scientific subfields highly related to biomedicine were considered in the main analysis. Data were downloaded on June 11, 2022.
    Main Outcomes and Measures: Proportion of US-based top-cited biomedical scientists who had any (1996-2022), recent (2015-2022), and current (2021-2022) funding. Comparisons of funded and nonfunded scientists assessed total citations and a composite citation index.
    Results: There were 204 603 records in RePORTER (1996-2022) and 75 316 US-based top-cited scientists in the career-long citation database; 40 887 scientists were included in the main analysis. The proportion of US-based top-cited biomedical scientists (according to career-long citation impact) who had received any federal funding from biomedical research agencies was 62.7% (25 650 of 40 887) for any funding (1996-2022), 23.1% (9427 of 40 887) for recent funding (2015-2022), and 14.1% (5778 of 40 887) for current funding (2021-2022). Respective proportions were 64.8%, 31.4%, and 20.9%, for top-cited scientists according to recent single-year citation impact. There was large variability across scientific subfields (eg, current funding: 31% of career-long impact top-cited scientists in geriatrics, 30% in bioinformatics and 29% in developmental biology, but 0% in legal and forensic medicine, general psychology and cognitive sciences, and gender studies). Funded top-cited researchers were overall more cited than nonfunded top-cited scientists (median [IQR], 9594 [5650-1703] vs 5352 [3057-9890] citations; P < .001) and substantial difference remained after adjusting for subfield and years since first publication. Differences were more prominent in some specific biomedical subfields.
    Conclusions and Relevance: In this survey study, biomedical federal funding had offered support to approximately two-thirds of the top-cited biomedical scientists at some point during the last quarter century, but only a small minority of top-cited scientists had current federal biomedical funding. The large unevenness across subfields needs to be addressed with ways that improve equity, efficiency, excellence, and translational potential.
    DOI:  https://doi.org/10.1001/jamanetworkopen.2022.45590
  32. PLoS One. 2022 ;17(12): e0278822
      This paper aims to provide insight into the driving distraction domain systematically on the basis of scientific knowledge graphs. For this purpose, 3,790 documents were taken into consideration after retrieving from Web of Science Core Collection and screening, and two types of knowledge graphs were constructed to demonstrate bibliometric information and domain-specific research content respectively. In terms of bibliometric analysis, the evolution of publication and citation numbers reveals the accelerated development of this domain, and trends of multidisciplinary and global participation could be identified according to knowledge graphs from Vosviewer. In terms of research content analysis, a new framework consisting of five dimensions was clarified, including "objective factors", "human factors", "research methods", "data" and "data science". The main entities of this domain were identified and relations between entities were extracted using Natural Language Processing methods with Python 3.9. In addition to the knowledge graph composed of all the keywords and relationships, entities and relations under each dimension were visualized, and relations between relevant dimensions were demonstrated in the form of heat maps. Furthermore, the trend and significance of driving distraction research were discussed, and special attention was given to future directions of this domain.
    DOI:  https://doi.org/10.1371/journal.pone.0278822
  33. Front Psychol. 2022 ;13 1064256
      With the respect to the key factors, namely the psychological state of individuals and organizations, psychological capital (PsyCap) is widely used in various fields, such as management decisions and organizational behavior. To fully show the related studies and their knowledge development and mapping path, in this paper, we examine 2,786 papers about the PsyCap related research from 1970 to 2021. Based on the bibliometric analysis and main path demonstration (the tools are Cite-Space and Pajke, respectively), we derive some conclusions as follows: (1) the publication number about the PsyCap study is growing rapidly and it is a highly cross-cutting research topic. (2) The main authors come from Australia, the United States, and China, and also are the core researchers. (3) Refinement and measurement in the PsyCap study are constant and hot topics. (4) Stress, performance and well-being issues among students, health care workers and corporate employees are core research themes, and team organization, creativity, innovation, and COVID-19 are hot topics in this field. The bibliometric analysis are quantitatively analyzed to provide scholars with a more comprehensive insight into PsyCap research. The main path demonstration helps scholars to understand the main lines and key nodes of development in the field of psychological capital.
    Keywords:  bibliometric visualization; burst detection; knowledge development; main path analysis; psychological capital
    DOI:  https://doi.org/10.3389/fpsyg.2022.1064256
  34. Cureus. 2022 Nov;14(11): e30958
      The COVID-19 pandemic has led to a global crisis and has affected the Caribbean islands, leading to significant health and socioeconomic consequences in this region. Efforts to mitigate the burden of this disease have led to an accelerated amount of research in the English-speaking Caribbean (ESC). This bibliometric analysis aimed to evaluate the COVID-19-related scientific literature from the ESC nations. A total of 175 articles were included and analyzed from an initial PubMed search (n = 638) for COVID-19-related scientific literature from the ESC nations published between January 1, 2020, and June 30, 2022. Microsoft Excel 2016 (Microsoft Corporation, Redmond, Washington) and the VOSviewer (version 1.6.18) were used to characterize countries, authorship, journals, affiliations, and keywords of the COVID-19-related articles. Trinidad and Tobago (38%), Jamaica (22%), Barbados (20%), and Grenada (15%) contributed to the greatest number of publications. The University of the West Indies (UWI) campuses in Trinidad and Tobago, Jamaica and Barbados, and St. George's University in Grenada were the most prolific institutions. Srikanth Umakanthan from the UWI was the most prolific author. Cureus, SN Comprehensive Clinical Medicine, and Frontiers in Public Health were the first three most productive journals; 59% of the 175 articles had either the first or last author affiliated with an institution in the ESC, and 19% of the articles were country-focused: Trinidad and Tobago (16/175), Jamaica (9/175), Barbados (5/175), and Antigua and Barbuda (2/175). Among the top themes of research, 27% were outbreak response and rearrangements, epidemiological studies (23%), clinical management (23%), and medical education (13%). Over the last two years, an interest stimulated by the pandemic has expanded the research in ESC countries. However, gaps in the knowledge exist, especially in the epidemiology of COVID-19 complications in the sub-populations of chronic non-communicable diseases, post-COVID syndrome, and the long-COVID syndrome in the region. Hence, there is enormous scope for more research across the region.
    Keywords:  barbados; caribbean; covid-19; global health diplomacy; grenada; jamaica; the university of the west indies; trinidad and tobago; vaccine hesitancy; west indies
    DOI:  https://doi.org/10.7759/cureus.30958
  35. Herit Sci. 2022 ;10(1): 189
      Using past material and spiritual remains, cultural heritage examines communities' identity formation across time. Cultural heritage requires public and private institutions to care about its restoration, maintenance, conservation, and promotion. Through a bibliometric perspective, this study has analyzed, quantified, and mapped the scientific production of the fourth industrial revolution applied to heritage studies from 2016 to 2021 in the Scopus and Web of Science databases. Biblioshiny software from RStudio was employed to categorize and evaluate the contribution of authors, countries, institutions, and journals. In addition, VOSviewer was used to visualize their collaboration networks. As a main result, we found that augmented reality and remote sensing represent the research hotspot concerning heritage studies. Those techniques have become common in archaeology, as well as museums, leading to an increase in their activity. Perhaps, more recent tools, such as machine learning and deep learning, will provide future pathways in cultural heritage from data collected in social networks. This bibliometric analysis, therefore, provides an updated perspective of the implementations of technologies from industry 4.0 in heritage science as a possible guideline for future worldwide research.
    Keywords:  Bibliometric; Biblioshiny; Heritage; Industry 4.0; Scopus; VOSviewer; Web of Science
    DOI:  https://doi.org/10.1186/s40494-022-00821-3
  36. Medicine (Baltimore). 2022 Dec 02. 101(48): e32081
      This study aims to demonstrate current research priorities and predict future trends in the link between kidney disease and gut microbiota by means of scientometric analysis. We collected nearly 20 years (2001-2020) of publications related to kidney disease and gut microbiota in the Web of Science database. CiteSpace was used to evaluate the knowledge mapping. There are 965 manuscripts about kidney disease and gut microbiota in total, and faster growth after 2016. The country, institution, and author who posted the most are the USA, Univ Calif Irvine, and DENISE MAFRA, respectively. The frequencies are 109, 16, and 17. The most important of them are FRANCE (0.23), Fed Univ Parana UFPR (0.13), and VAZIRI ND (1.14), owing to their highest centrality. In addition, the cited documents that have contributed the most to the co-citations are Wong J (2014); the most key cited reference is Rossi M (2016); the most commonly used keywords are chronic kidney disease, gut microbiota and indoxyl sulfate. Through scientometric analysis of the past 20 years, we obtained the knowledge map of this information, which has important guiding significance for accurately and quickly locating trends in this field.
    DOI:  https://doi.org/10.1097/MD.0000000000032081
  37. Adv Radiat Oncol. 2023 Mar-Apr;8(2):8(2): 101121
      Purpose: While a rising share of scientific research articles are being published in open access (OA) journals, their impact on resident research in radiation oncology is unknown. Thus, we sought to determine the number, content, and costs of first-author, PubMed-searchable articles radiation oncology residents in the United States (US) published in OA journals in recent years.Methods and Materials: We built a database of first-author, PubMed-searchable articles published by US radiation oncology residents who graduated between 2015 and 2019. We then classified each journal in which these articles appeared as either OA or non-OA and obtained the current article-processing charge (APC) for each publication that appeared in an OA journal.
    Results: The residents in this study published 2637 first-author, PubMed-searchable articles, 555 of which (21.0%) appeared in 138 OA journals. The number of publications in OA journals per resident increased from 0.47 for the class of 2015 to 0.79 for the class of 2019. Publications in OA journals garnered fewer citations than those in non-OA journals (8.9 vs 14.9, P < .01). Furthermore, 90.6% of OA journals levy an APC for original research reports (median, $1896), which is positively correlated with their 2019 impact factor (r = 0.63, P < .01). Aggregate APCs totaled $900,319.21 and appeared to increase over the study period.
    Conclusions: The number of first-author, PubMed-searchable articles published by graduating US radiation oncology residents in OA journals rose significantly between 2015 and 2019. To maximize the benefits of OA publishing in the future, US radiation oncology residents will need to ensure that they use vetted OA journals to publish their research findings and avoid predatory journals.
    DOI:  https://doi.org/10.1016/j.adro.2022.101121
  38. Arch Suicide Res. 2022 Dec 06. 1-15
      BACKGROUND: In most countries, men complete suicide at twice the rate of women; masculinity plays an important role in placing men at a greater risk of suicide. This study identifies and describes trends in the topics discussed within the masculinity and suicide literature and explores changes over time.METHODS: We retrieved publications relating to masculinity and suicide from eight electronic databases and described origins in the field of research by reference to the first decade of publications. We then explored the subsequent evolution of the field by analysis of the content of article titles/abstracts for all years since the topic first emerged, and then separately by three epochs.
    RESULTS: We included 452 publications (1954-2021); research output has grown substantially in the last five years. Early publications framed suicide in the context of severe mental illness, masculinity as a risk factor, and suicidality as being aggressive and masculine. We observed some differences in themes over time: Epoch 1 focused on sex differences in suicidality, a common theme in epochs 2 was relationship to work and its effect on men's mental health and suicidality, and epoch 3 had a focus on help-seeking in suicidality.
    CONCLUSION: The research field of masculinity and suicide is growing strongly, as evidenced by recent increase in publication volume. The structure, content and direction of the masculinity and suicide research are still evolving. Researchers must work with policymakers and practitioners to ensure that emerging findings are translated for use in programs designed to address suicide in boys and men.HIGHLIGHTSMasculinity and suicide as a field is not new, with its origins in the literature dating back to 1954.More than half of the total research output in the field (1954-2021) has been published in the last five years.Early work focused on individual-level risk factors to male suicide (e.g., severe mental illness), while contemporary research focused on social and cultural determinants of male suicide (e.g., help-seeking).
    Keywords:  Bibliometrics; masculinity; suicide prevention; suicide research
    DOI:  https://doi.org/10.1080/13811118.2022.2151956
  39. J Can Health Libr Assoc. 2022 Dec;43(3): 93-103
      Introduction: Evidence-based practice is an important aspect of health science librarianship. However, good evidence-based practice can only occur if the body of evidence is also of adequate quality. By using bibliometric techniques to map the health science librarianship research field, one can better understand the properties of the evidence base in health science librarianship.Methods: The Library Literature & Information Science Full Text database was used to generate a bibliography of publications pertaining to health librarianship limited to the time span of 2012-2022. Using Excel and Microsoft Power BI, a descriptive analysis was conducted. VosViewer was used to create a subject term co-occurrence map.
    Results: The average number of publications per year is 207.3 and it was trending downwards for 2012-2022. The most frequently assigned subject term was "survey". The average number of authors per paper is 2.5 and was trending upwards. The subject term co-occurrence map identified 5 clusters of keywords, which were interpreted as major themes found in the body of literature.
    Discussion: The 5 keyword clusters were interpreted as major themes found in the body of literature. The identified themes were professional development, measuring the value output of librarian services, measuring the return on investment of library resources, improving the quality of LIS research, and outreach to other library and healthcare institutions. This depicts the health science librarianship research landscape as one of collaboration, concerned with finding ways of demonstrating value, and connecting with other types of libraries and the public.
    DOI:  https://doi.org/10.29173/jchla29626
  40. Medicine (Baltimore). 2022 Dec 02. 101(48): e32118
      BACKGROUND: Coronavirus disease 2019 (COVID-19)-associated mucormycosis (CAM) is a relatively new concept in the literature that emerged during the pandemic. Bibliometric analysis is a type of analysis that uses mathematical and statistical methods to study the formal properties of knowledge areas. This study aimed to reveal the main themes, conceptual structures, and trends of bibliometric studies on mucormycosis in 2 different periods, pre-and during the pandemic.METHODS: This study consisted of 2 periods: pre-COVID-19 and COVID-19. Articles were collected from the Web of Science (WOS) Core Collection database. We provided AND and OR connectors for the keyword query and selected studies based on relevant keywords. Collected data were classified based on their publication date and examined using the R programming language (Version 4.0.3) package Bibliometrix and SciMAT Software.
    RESULTS: A total of 1261 articles were investigated, and performance and information structure analyses were conducted. Based on Bradford's law, the Journal of Fungi was the top-ranked journal in both periods. Cureus and mycoses were placed 2nd and 3rd in the second period. India is the largest contributor. In performance analysis, conceptual structures such as Rhizopus oryzae, epidemiology, diagnosis, management, treatment, and outcomes were at the forefront of mucormycosis publications during the COVID-19 period.
    CONCLUSIONS: Research trends have shifted to the clinical treatment and management of COVID-19. Therefore, pathogenesis, diagnosis, follow-up, and treatment strategies for CAM should be developed in the future.
    DOI:  https://doi.org/10.1097/MD.0000000000032118
  41. Front Psychol. 2022 ;13 960666
      In the field of qualitative research, life stories are consolidated as one of the most important techniques within the biographical method. However, due to the multiplicity of techniques covered by this method and the disciplines in which it is applied, the contributions and scope of life histories do not present a clear delimitation. By contrast, a considerable conceptual confusion persists and the transfer of its production remains very narrow. In this sense, this article aims to clarify the field of knowledge generated through life stories. To this end, it innovatively applies the bibliometric method. Making use of performance analysis and scientific mapping through the VosViewer application, it studies a body of 2670 articles indexed in the Web of Science. The results show how knowledge transferred from psychology through its major schools of thought occupies a central place. This leaves in a secondary position the knowledge produced by other disciplines such as sociology or anthropology, which is not transferred in the main forums of scientific impact. In this way, the conclusion points to the need to open up new lines of research to find out the differences between the different techniques and disciplines when applying this methodology.
    Keywords:  VOSviewer; bibliometric analysis; biographical method; life stories; scientific production
    DOI:  https://doi.org/10.3389/fpsyg.2022.960666
  42. Scientometrics. 2022 Nov 21. 1-35
      This study analyzes the characteristics and development of Brazilian research on women's and gender studies using a new comprehensive data source that is still hardly explored in bibliometric studies called 1Findr. The search expression forms a part of a methodological proposition for similar studies, based on the literature review of other analogous studies and on the historical and current characteristics of Brazil. We analyzed 31,609 Brazilian articles on women's and gender studies based on bibliometric indicators including activity, collaboration, and thematic association, with excerpts from the 1970s to 2019. Our results show that, initially, research was linked to the health sciences and was carried out in institutions in the Southeast and South of the country; however, this trend started changing since the 1990s, when two journals specialized in the area were first developed in Brazil and when researchers in the human and social sciences started working with this subject. Since then, the volume of articles, collaboration, and research has grown throughout the country, although production is still concentrated in the Southeast and South. Federal public universities are the main research actors, and researchers prioritize national journals and the Portuguese language. However, the main characteristic, which increases over time, is plurality: in relation to science in general and to other areas of Brazilian research, women's and gender studies present a greater plurality in terms of its publication characteristics, for example, in relation to the amount and percentage of languages. Plurality is also observed in the fact that, over the years, researchers from new disciplines have started to publish on gender studies, making the area more and more inter- and multidisciplinary, and also consolidating it scientifically, in the sense that it has become a subject of interest for all areas of research. Its presence in journals with the best ratings in the Brazilian research system supports the understanding that this is a scientifically consolidated area. In contrast, despite its continuous growth, collaboration is a rare phenomenon, and specific characteristics of studies carried out with foreign partners can be observed. Collaboration clusters among national institutions are characterized, among other factors, by their geographic proximity and the central role of major universities, such as Universidade de São Paulo, and others associated with the history of the area in the country, such as Universidade de Campinas, Universidade Federal de Santa Catarina and Universidade Federal do Rio Grande do Sul. The dataset obtained, prepared, and used in the present research is available for new studies.Supplementary Information: The online version contains supplementary material available at 10.1007/s11192-022-04545-w.
    Keywords:  1Findr; Bibliometrics; Brazilian science; Scientometrics; Women’s and gender studies
    DOI:  https://doi.org/10.1007/s11192-022-04545-w
  43. Rev Peru Med Exp Salud Publica. 2022 Apr-Jun;39(2):39(2): 236-240
      Scientists have always looked for ways to evaluate research results to recognize and reward their efforts, and to support decisions regarding programs and public policies. The metrics of scientific impact have become, in recent decades, the driving force behind the academic environment. The work of researchers, scientific journals, databases and publishers, research institutions, and funding agencies is driven by the impact of the research they produce, publish, index, promote and finance. Bibliometric indicators are widely used for the evaluation of scientific output, despite the lack of a clear relationship between citations and quality, impact, or scientific merit. Furthermore, the relationship is even less evident regarding innovation, which is an inherent characteristic of scientific research. This article describes the main types of metrics used to evaluate scientific output, as well as its features, potentials, and limitations.
    DOI:  https://doi.org/10.17843/rpmesp.2022.392.11171
  44. Zhongguo Zhong Yao Za Zhi. 2022 Nov;47(22): 6235-6248
      In light of the tremendous number of patients with vascular dementia in China, it is of great significance for the treatment of this disease to summarize related research focuses. In this study, articles on the treatment of vascular dementia, which were included in CNKI and Web of Science from January 1, 2012 to December 31, 2021, were analyzed. Specifically, CiteSpace 5.7.R2 was employed to visualize nationalities of authors, author affiliations, authors, keywords, and journals, and dissect the status quo and trend of research on the treatment of this disease. On this basis, the research focuses and evolution were elucidated. The findings are expected to serve as reference for the future research. Finally, 2 579 Chinese articles and 453 English articles were included. The annual number of published articles showed an upward trend. Authors from China published most papers and England had the highest centrality value. HU Yue-qiang and LIU Cun-zhi respectively published the most Chinese and English articles. Guangxi University of Chinese Medicine and Capital Medical University respectively topped the author affiliations in the number of published Chinese and English articles. Among the English journals, Anal Biochem and Stroke separately boasted the highest centrality value and the highest cited frequency. The analysis of keywords in the Chinese articles suggested that most studies on the treatment of vascular dementia focused on the observation of patients' mobility after treatment. Moreover, as for the therapeutic method, western medicine, as well as the Chinese medicine and acupuncture frequently attracted the attention of scholars. Basic research highlighted the oxidative stress, angiogenesis, and apoptosis. According to the analysis result of keywords in English articles on treatment of vascular dementia, the focus was the improvement of the memory function of patients with vascular dementia. As to the therapeutic method, drug therapy was frequently studied compared with other methods. The basic research focused on autophagy, nerve regeneration, and oxidative stress. This study concludes that the future research trend might be the combination of Chinese and western medicine in the treatment of vascular dementia.
    Keywords:  CiteSpace; knowledge graph; vascular dementia; visualization
    DOI:  https://doi.org/10.19540/j.cnki.cjcmm.20220721.502
  45. Environ Sci Pollut Res Int. 2022 Dec 06.
      In recent years, photocatalysts are becoming attractive to researchers in exploring their application for treatment of air pollutants. Exposure to ultra-violet visible (UV-VIS) light on photocatalysts often makes them active in decomposing various toxic materials into less or environment-friendly products. Thus, identification, as well as simple synthesis and processing of photocatalysts, could ultimately lead to technologies for the cost-effective mitigation of environmental hazards. A bibliometric analysis has been carried out here to understand and assess the development in photocatalyst research. The data retrieved from the Scopus database on the topic for 2000-2020 were analyzed to investigate the research activities of the past to foresight the future. Various facets of bibliometry were investigated to produce this holistic article. The contribution of various countries, institutions, and authors were investigated. Numerous facets of photocatalyst such as types of photocatalysts, their modification through metal and non-metal doping, their pollutants treatment potency, types of reactors for photocatalysis, factors influencing treatment performance, and models used for designing reactors were examined. In brevity, substantial growth was observed in the last two decades. Contribution of China, the USA, Japan, and India were notable. Chinese universities contributed majorly to the research. Applied Catalysis B: Environmental Journal was the topic's main journal and Titanium dioxide was the hotspot in photocatalytic research. The research development, problem disclosure, adopted strategies, and materials explored on the photocatalysis for air pollution treatment over recent years across the world could be insightful to the researchers and eventually will be beneficial to formulate new research strategies.
    Keywords:  Air pollution; Doping; Models; Photocatalysis Performance influencer; Photocatalysts; Reactors
    DOI:  https://doi.org/10.1007/s11356-022-24267-z
  46. Nurse Educ Today. 2022 Dec 01. pii: S0260-6917(22)00411-7. [Epub ahead of print]121 105674
      OBJECTIVES: This study aimed to identify the knowledge structure of medication safety nursing education literature by developing schematic diagrams of the relationship between keywords from a macro perspective. This study also identifies the research topics and trends over time.DESIGN: This quantitative content study used text network analysis to explore keywords and research topics using topic modeling within the medication safety nursing education literature.
    DATA SOURCES: PubMed, EMBASE, and Cochrane databases were used to search for the medication safety nursing education literature published until December 2021.
    METHODS: Keywords from 2085 articles were examined using text network analysis and topic modeling with NetMiner 4.4.3.
    RESULTS: The keywords with the most frequency and the highest networking degree in centrality were "patient," "medication," "program," "nurse," and "care." The emerging keywords assessed by time periods were identified; the first phase ("heart failure," "insulin," "chemotherapy," and "infusion"), the second phase ("medication errors," "staff," and "information"), the third phase ("program," "management," and "data"). The results of topic modeling were as follows: safe medication administration, safe medication reconciliation process, medication education for patients, medication errors in nursing practice, and multidisciplinary teamwork for medication safety.
    CONCLUSION: These findings will help nursing researchers and educators to understand the trends and insights for medication safety education and educate future nurses to provide safer nursing care.
    Keywords:  Education; Knowledge structure; Medication safety; Nurses; Nursing; Text network analysis; Topic analysis
    DOI:  https://doi.org/10.1016/j.nedt.2022.105674
  47. Scientometrics. 2022 Nov 28. 1-43
      Over the last two decades, green and sustainable business models (GnSBMs) have become a prominent topic of discussion among scholars, practitioners and policymakers. Preponderance of research and an increasing global pressure to adopt GnSBMs necessitate a comprehensive understanding of the state of research on GnSBMs. Towards this end, we extracted 851 publications on GnSBMs from the Scopus database and employed a series of bibliometrical techniques to: (1) explore the historical roots and sleeping beauties, (2) assess the life cycle, (3) map the conceptual evolution and (4) propose a research agenda for this growing field. Our analysis revealed that research on GnSBMs is moving from a multidisciplinary to an interdisciplinary domain. Its historical roots can be traced to the pioneering works on business strategy in the 1950s, environmental science in the early 1960s and stakeholder theory in the 1980s. Life cycle analysis indicated that research on GnSBM went through an introductory stage from 2002 to 2013 and then began to rapidly grow in 2014, and this growth is forecast to continue until circa 2040. The conceptual structures from 2002 to 2013 and 2014 to 2020 were mapped and an agenda for future research was proposed.Supplementary Information: The online version contains supplementary material available at 10.1007/s11192-022-04577-2.
    Keywords:  Circular business models; Co-word analysis; Green business models; Life cycle analysis; Reference publication year spectroscopy; Sharing business models; Social business models; Sustainable business models
    DOI:  https://doi.org/10.1007/s11192-022-04577-2
  48. An Acad Bras Cienc. 2022 ;pii: S0001-37652022000701706. [Epub ahead of print]94(suppl 3): e20210962
      Brazilian scientific production has been mostly developed (90%) by Brazilian universities, mainly graduate programs, which must be assessed and ranked by the Brazilian government for their maintenance. The Qualis system is used for this classification by valuing the scientific production of graduate programs, stratifying journals and assigning grades. Several Brazilian researchers affirm that the Qualis system is inaccurate and subjective because it is carried out by a group of researchers. This work aimed to propose methods to evaluate Brazilian scientific production in order to improve the assessment of graduate programs through multi-criteria methods in addition to Qualis. The application of different metrics presented results significantly different from Qualis, including the over valuation of journals with a low international impact factor. The proposed metrics considered: (i) web of science impact factor of the journals; (ii) Citations from articles; (iii) Citations of citations, i.e., a new metric; and (iv) H-Index for researchers. It was proposed the multi-criteria method, composed of the mentioned criteria, in addition to Qualis. For the sample of researchers, it was demonstrated that multi-criteria methods can assess scientific production more accurately. Therefore, they are more adequate to assess the Brazilian graduate programs, considering several internationally accepted criteria.
    DOI:  https://doi.org/10.1590/0001-3765202220210962
  49. Tissue Eng Part B Rev. 2022 Dec 07.
      The consequences of military conflict, accidents, and diseases have led to the definition - and subsequent study - of the pathological condition now known as volumetric muscle loss (VML). VML is a significant injury to skeletal muscle tissue on a scale that is endogenously irrecoverable and leads to chronic functional deficits and long-term disability. Currently, there lacks a definitive approach to meaningfully restore the tissue and function lost by those afflicted, ushering a need for scientific activities and associated funding to both facilitate a deeper understanding of the pathobiology of VML as well as to develop and assess clinically relevant therapeutics and treatment strategies. Thereby, evaluation of the VML field is crucial to gauging the return on resource expenditures and to understand the evolution of the field to guide future directions. This article presents a bibliometric analysis of publicly available data to explore the growth of the VML field since its genesis and to highlight its prosperity through its expanding literature, its development and evaluation of promising treatment strategies, rising financial investments, and innovation. Together, the bibliometric analysis reveals the field of VML as an emergent research focus that is productive and translational.
    DOI:  https://doi.org/10.1089/ten.TEB.2022.0150
  50. Front Vet Sci. 2022 ;9 1030454
      The present study constitutes a review of the scientific articles about animal welfare in terrestrial farmed animals, published in 19 countries of Latin America. The main objectives were to quantify and characterize articles produced between 1992 and 2021 in farm animals' welfare using "Web of Science [v.5.32]" and "CAB Abstracts" databases. A total of 663 articles were found for the period analyzed, which were mainly in English (87%). The countries with the most publications were Brazil (43%), México (25%), Chile (12%), Uruguay (10%), Colombia (4%) and Argentina (2%). Cattle was the farm species most considered in the publications (41%), and the studies addressed mostly the on-farm production stage (76%). There was a rapid increase in the number of articles published in the last 15 years, accounting for 95% of the publications. This could be related to the publication of welfare standards by the World Organization for Animal Health (WOAH) since 2005, the creation of the Collaborating Center for Animal Welfare and Sustainable Livestock Systems-Chile-Uruguay-México in 2009, a Regional Strategy of Animal Welfare prompted by the WOAH in 2012 and the inclusion of animal welfare in the veterinary curriculum. The fact that most articles were in English shows that Latin American researchers have somehow overcome the challenge of publishing in a non-native language and their research can be read/cited worldwide. However considerable gaps in scientific productivity were identified in comparison to European and North American countries. Scientific research concerning the livestock industry in Latin America faces new challenges arising from the need to move toward more sustainable production systems within the One Welfare and One Health frame.
    Keywords:  Latin America; animal behavior; animal welfare; farm animals; research; scientific publications; sustainability
    DOI:  https://doi.org/10.3389/fvets.2022.1030454
  51. Front Psychol. 2022 ;13 1036991
      University phase is a major turning point in youth's life and this is a time of profound mental and cognitive development of students. Without proper direction and guidance, it is common for students to develop deviant behaviors, non-law abidance and unhealthy beliefs. In this regard, an integral part of the educational process is the imparting of moral values and law-abiding behaviors in students. The objective of this study was to explore the role of higher education system in fostering law-abiding behavior among Chinese students, as well as the issues it causes for society. For this purpose, the principles of law-abiding behavior were studied and key psychological factors used in the system were identified. The suggestions of the bibliometric research are designed to improve and expand the method for preventing student misbehavior in educational institutions, hence enhancing the efficacy of preventative work with students. They may serve as the basis for the creation and enhancement of programs and strategies aimed at teaching lawful behavior among students. More than 3,785 articles were published related law-abiding behavior from 2000 to the end of July 2022 years were examined in this research using the Scopus database and the original sample was narrowed down to include only articles, book chapter and conference papers that contributed to law-abiding behavior and higher education literature. The VOS viewer software was used to execute the descriptive statistics and scientific mapping approaches using co-citation analysis. In the descriptive analysis, we analyzed publishing patterns over time, the geographical localization of the contributing institutions, journals, the most prolific authors. The findings of the present study may also provide the foundation for a planned educational initiative whose ultimate aim is to produce a fully realized, harmonious, self-reliant, mature, and law-abiding person. The study has provided supporting evidence for how youngsters legal sensibilities are shaped in universities have been implemented. Two distinct but interdependent educational spheres, the normative legal sphere and the space for the creation and development of students' personalities must work together to raise and educate youngsters.
    Keywords:  higher education; law abiding behavior; legal education; legal socialization; moral education; psychological factors
    DOI:  https://doi.org/10.3389/fpsyg.2022.1036991
  52. PLoS One. 2022 ;17(12): e0277814
      We investigate the citation frequency of retracted scientific papers in science. For the period of five years before and after retraction, we counted the citations to papers in a sample of over 3,000 retracted, and a matched sample of another 3,000 non-retracted papers. Retraction led to a decrease in average annual citation frequency from about 5 before, to 2 citations after retraction. In contrast, for non-retracted control papers the citation counts were 4, and 5, respectively. Put differently, we found only a limited effect of retraction: retraction decreased citation frequency only by about 60%, as compared to non-retracted papers. Thus, retracted papers often live on. For effective self-correction the scientific enterprise needs to be more effective in removing retracted papers from the scientific record. We discuss recent proposals to do so.
    DOI:  https://doi.org/10.1371/journal.pone.0277814
  53. Philos Trans A Math Phys Eng Sci. 2023 Jan 23. 381(2241): 20210413
      We build and analyse the network of 100 top-cited nodes (research papers and books from Google Scholar; the strength or citation of the nodes range from about 44 000 up to 100) starting in early 1980 until last year. These searched publications (papers and books) are based on Quantum Annealing Computation and Information categorized into four different sets: (A) Quantum/Transverse Field Spin Glass Model, (B) Quantum Annealing, (C) Quantum Adiabatic Computation and (D) Quantum Computation Information in the title or abstract of the searched publications. We fitted the growth in the annual number of publication ([Formula: see text]) in each of these four categories, A-D, to the form [Formula: see text] where [Formula: see text] denotes the time in years. We found the scaling time [Formula: see text] to be of the order of about 10 years for categories A and C, whereas [Formula: see text] is of the order of about 5 years for categories B and D. This article is part of the theme issue 'Quantum annealing and computation: challenges and perspectives'.
    Keywords:  growth time; network growthbehaviour; quantum annealing; quantum computation; research network
    DOI:  https://doi.org/10.1098/rsta.2021.0413
  54. Environ Pollut. 2022 Dec 01. pii: S0269-7491(22)01996-0. [Epub ahead of print] 120782
      Alterations in the concentrations of trace elements may play a vital role in Alzheimer dementia progression. However, previous research results are inconsistent, and there is still a lack of review on the relationship between all the studied-trace elements and AD from various perspectives of population-based studies. In this study, we systematically reviewed previous population-based studies and identified the altered trace elements in AD patients. We searched the Web of Science Core Collection, PubMed, and Scopus database, and ultimately included 73 articles. A bibliometric analysis was conducted to explore the evolution of the field from an epidemiological perspective. Bibliometric data such as trace elements, biological materials, detection methods, cognitive tests, co-occurrence and co-citation statistics are all analyzed and presented in a quantitative manner. The 73 included studies analyzed 39 trace elements in total. In a further meta-analysis, standardized mean differences (SMDs) of 13 elements were calculated to evaluate their altered in AD patients, including copper, iron, zinc, selenium, manganese, lead, aluminum, cadmium, chromium, arsenic, mercury, cobalt, and manganese. We identified four trace elements-copper (serum), iron (plasma), zinc (hair), and selenium (plasma)-altered in AD patients, with SMDs of 0.37 (95% confidence interval [CI]: 0.10, 0.65), -0.68 (95% CI: -1.34, -0.02), -0.35 (95% CI: -0.62, -0.08), and -0.61 (95% CI: -0.97, -0.25), respectively. Finally, we formed a database of various trace element levels in AD patients and healthy controls. Our study can help future researchers gain a comprehensive understanding of the advancements in the field, and our results provide comprehensive population-based data for future research.
    Keywords:  Alzheimer dementia; Bibliometrics; Population-based study; Trace element; meta-Analysis
    DOI:  https://doi.org/10.1016/j.envpol.2022.120782
  55. Int J Gynaecol Obstet. 2022 Dec 10.
      Despite the amount of research into hysteroscopic myomectomy, questions about the optimal treatment of heavy menstrual bleeding remain. This study reviewed publication trends on this topic from 2002 - 2019 and assessed the usefulness of studies. 580 articles were published on PubMed in this timeframe, in 15 different languages. There were meta-analyses (1.6%), systematic reviews (12%) and randomized controlled trials (4.2%). 12% were published in high impact factor journals. After applying our selection criteria, the usefulness of 37 articles was assessed: one article scored high, 31 scored moderate and five scored low. The costs of these studies were estimated 971,700 US$.
    Keywords:  Usefulness; hysteroscopy; leiomyoma; menstrual bleeding
    DOI:  https://doi.org/10.1002/ijgo.14613
  56. J Bone Joint Surg Am. 2022 Dec 07. 104(23): e100
      BACKGROUND: The National Institutes of Health (NIH) remains one of the predominant sources of biomedical research funding in the United States, yet its impact on total hip and knee arthroplasty research is poorly understood. This study defines the portfolio of NIH funding for total joint arthroplasty (TJA) and the impact of orthopaedic surgeons on this portfolio.METHODS: The Research Portfolio Online Reporting Tools Expenditures and Results (RePORTER) database was queried for NIH grants that had been awarded for total hip and knee arthroplasty and total NIH funding from 2010 to 2020. Compound annual growth rates (CAGRs) were calculated. Funding totals were compared with those from 20 other clinical areas. The principal investigators (PIs) and grants were characterized, and comparisons were made with use of the Student t test.
    RESULTS: A total of 489 grants were awarded, totaling $181 million (CAGR of 10.3%). This was >3 times the growth rate for the total NIH budget (CAGR of 2.9%), which increased from $31.2 to $41.7 billion over the 11-year period. When compared with 20 other clinical areas, TJA received the least amount of NIH funding over that period. Alzheimer disease received the most funding ($12.1 billion, CAGR of 19.5%), and cerebral palsy received the penultimate amount of funding ($284 million, CAGR of 6.3%). The R01 grant mechanism was the predominant source (63.1%), and the Mayo Clinic (Rochester, Minnesota) received the most funding (9.7%). Departments of orthopaedic surgery were awarded the most funding (23.5%), yet only 20 orthopaedic surgeons were identified as PIs (16.0%). There were no significant differences in NIH funding totals by PI demographic and academic characteristics (p > 0.05), yet orthopaedic surgeons had among the highest Hirsch indices (h-indices) (p < 0.001). Funding supported clinical (63.5%), translational (19.3%), basic science (7.1%), and other types (10.1%) of research. The top areas with funding were postoperative complications (44.4%), postoperative pain management (17.6%), rehabilitation (15.1%), and implant design (12.4%).
    CONCLUSIONS: There is a paucity of orthopaedic surgeon representation among NIH grants awarded for TJA. Opportunities may exist for orthopaedic surgeons to collaborate in identified areas of clinical interest. Additional research is needed to understand the obstacles to obtaining NIH grant funding for orthopaedic surgeon PIs.
    CLINICAL RELEVANCE: Increasing the levels of funding from the NIH is a strategic priority for departments of orthopaedic surgery. Understanding levels of funding for clinical areas in total joint arthroplasty is critical to foster research and discovery support from the NIH.
    DOI:  https://doi.org/10.2106/JBJS.22.00025
  57. J Clin Epidemiol. 2022 Dec 02. pii: S0895-4356(22)00307-9. [Epub ahead of print]
      OBJECTIVE: To explore indicators of the following questionable research practices (QRPs) in randomized controlled trials (RCTs): (1) risk of bias in four domains (random sequence generation, allocation concealment, blinding of participants and personnel, and blinding of outcome assessment); (2) modifications in primary outcomes that were registered in trial registration records (proxy for selective reporting bias); (3) ratio of the achieved to planned sample sizes; and (4) statistical discrepancy.STUDY DESIGN AND SETTING: Full-texts of all human RCTs published in PubMed in 1996-2017 were automatically identified, and information was collected automatically. Potential indicators of QRPs included author-specific, publication-specific, and journal-specific characteristics. Beta, logistic, and linear regression models were used to identify associations between these potential indicators and QRPs.
    RESULTS: We included 163,129 RCT publications. The median probability of bias assessed using RobotReviewer software ranged between 43% and 63% for the four risk of bias domains. A more recent publication year, trial registration, mentioning of CONSORT-checklist, and a higher journal impact factor were consistently associated with a lower risk of QRPs.
    CONCLUSION: This comprehensive analysis provides insight into indicators of QRPs. Researchers should be aware that certain characteristics of the author team and publication are associated with a higher risk of QRPs.
    Keywords:  RCT; bias; meta-research; questionable research; responsible research; selective reporting
    DOI:  https://doi.org/10.1016/j.jclinepi.2022.11.020
  58. Osteoarthr Cartil Open. 2021 Dec;3(4): 100215
      Objective: To assess the extent and trends in registration of Orthopaedic randomized clinical trials (RCTs) between 2015 and 2020.Design: Epidemiological study. Primary publications of RCTs published in top Orthopaedic journals (ISI Journal Citation Reports 2019 rankings) between 2015 and 2020 were included in this meta-epidemiological study with no restrictions on patient population, intervention/control groups or outcome type. Independent reviewers in pairs were involved in RCT selection and data extraction. The proportion of RCTs published that were registered (prospectively or retrospectively) or not registered were reported using counts and percentages stratified by years for each journal.
    Results: A total of 474 primary RCTs were considered eligible. We identified 157 out of 474 RCTs (33% of RCTs across journals) that were reported to have been registered prospectively.The proportion of prospective RCT registrations had increased by 40% (10%-50%) between 2015 and 2020. On the other hand, the proportion of RCTs with no registrations were reduced by 29% (50%-21%) between 2015 and 2020.
    Conclusion: Prospective RCT registration in the past 5 years in the field of orthopaedic has increased, but 2/3 of published RCTs still failed to report prospective registration.
    Keywords:  Orthopaedics; Randomised clinical trials; State of evidence; Transparency
    DOI:  https://doi.org/10.1016/j.ocarto.2021.100215
  59. J Oncol. 2022 ;2022 5095176
      Cancer, as the second leading cause of death worldwide, has become an ongoing public health challenge and its treatment has received much attention, with immunotherapy becoming a hot research topic in recent years. The interferon gene stimulating factor (STING)-mediated signaling pathway has a "double-edged sword" role in cancer, which plays different roles in different types and stages of tumors. In this paper, we discuss the current research status, cooperation, and hotspots of STING signaling pathway in cancer from 2008-2022 using CiteSpace software based on the literature of cancer and STING signaling pathway. In addition, we predicted future research trends in this field by analysis, and the results showed that the STING signaling pathway is rapidly increasing in cancer research, and its role in tumor microenvironment and immunotherapy has become a new hot spot in current research and will continue to receive high attention.
    DOI:  https://doi.org/10.1155/2022/5095176
  60. Soc Sci Med. 2022 Nov 25. pii: S0277-9536(22)00831-0. [Epub ahead of print]317 115525
      BACKGROUND: The Opioid Overdose Crisis (OOC) continues to generate morbidity and mortality in the United States, outpacing other prominent accident-related reasons. Multiple disciplines have applied geographic information science (GIScience) to understand geographical patterns in opioid-related health measures. However, there are limited reviews that assess how GIScience has been used.OBJECTIVES: This scoping review investigates how GIScience has been used to conduct research on the OOC. Specific sub-objectives involve identifying bibliometric trends, the location and scale of studies, the frequency of use of various GIScience methodologies, and what direction future research can take to address existing gaps.
    METHODS: The review was pre-registered with the Open Science Framework ((https://osf.io/h3mfx/) and followed the PRISMA-ScR guidelines. Scholarly research was gathered from the Web of Science Core Collection, PubMed, IEEE Xplore, ACM Digital Library. Inclusion criteria was defined as having a publication date between January 1999 and August 2021, using GIScience as a central part of the research, and investigating an opioid-related health measure.
    RESULTS: 231 studies met the inclusion criteria. Most studies were published from 2017 onward. While many (41.6%) of studies were conducted using nationwide data, the majority (58.4%) occurred at the sub-national level. California, New York, Ohio, and Appalachia were most frequently studied, while the Midwest, north Rocky Mountains, Alaska, and Hawaii lacked studies. The most common GIScience methodology used was descriptive mapping, and county-level data was the most common unit of analysis across methodologies.
    CONCLUSIONS: Future research of GIScience on the OOC can address gaps by developing use cases for machine learning, conducting analyses at the sub-county level, and applying GIScience to questions involving illicit fentanyl. Research using GIScience is expected to continue to increase, and multidisciplinary research efforts amongst GIScientists, epidemiologists, and other medical professionals can improve the rigor of research.
    Keywords:  Bibliometrics; Geographic information science (GIScience); Geographic information systems (GIS); Opioid crisis; Scoping review; Spatial analysis; United State
    DOI:  https://doi.org/10.1016/j.socscimed.2022.115525
  61. Heliyon. 2022 Dec;8(12): e12005
      The purpose of this article consists of analyzing publications discussing the use of agent-based artificial intelligence models in sustainable agriculture research. The analysis involved bibliometric indicators and the Rstudio software with Bibliometrix library. The methodology is descriptive with a quantitative approach. Scientific databases SCOPUS and Web of Science were consulted and the PRISMA methodology was used during the selection process. This led to finding 86 publications that met the inclusion criteria. Amongst the results, United States was listed as the country with the highest production of scientific material, although France had a higher impact. Additionally, the bibliographical resources that help promote scientific development are open source. It was concluded that the agent-based model has been adopted to simulate different scenarios, which help decision-makers to formulate public policies in favor of sustainable agriculture. This optimizes the use of natural resources and reduces negative consequences for the environment, while also delivering value for the stakeholders of the agricultural system.
    Keywords:  Agent-based model; Artificial intelligence; Decision-making; Public policy; Sustainable agriculture; Sustainable development
    DOI:  https://doi.org/10.1016/j.heliyon.2022.e12005
  62. J Dent. 2022 Dec 03. pii: S0300-5712(22)00437-7. [Epub ahead of print] 104385
      OBJECTIVE: We aimed to assess the extent of social media sharing of presumed predatory (PP) dental journals and to compare level of engagement, type of accounts and characteristics of the articles published in presumed legitimate (PL) and PP journals.METHODS: Six hashtags were searched across three social media platforms (Instagram, Facebook and Twitter). Data extraction was performed and journals were classified into PP or PL in a multistep approach using MEDLINE, Beall's list and Directory of Open Access Journals (DOAJ). A checklist was created and used for studies not found in the aforementioned recognized databases.
    RESULTS: A total of 1742 posts were identified, with the majority (94%) found on Instagram. From the identified journals, 15.6% were PP. Over one-third of articles from PP journals (35.42%) were indexed on PubMed. The majority of presumed legitimate publications were published in dental specialty only journals (56.44%), compared to 24% in PP group. The majority of accounts were those of healthcare professionals with most publications related to prosthodontics and implantology (26.3%) and restorative and esthetic dentistry (14.4%), in PL and PP groups, respectively. Similar median number of followers/friends and comments were found between PL and PP groups.
    CONCLUSION: Our findings highlight that presumed predatory publications have comparable reach to PL journals on social media risking the sharing of unreliable and misleading information.
    CLINICAL SIGNIFICANCE: Researchers, traders and social media users should be capable of identifying presumed predatory dental publications. Means of moderating the influence of these publications should be explored.
    Keywords:  editorial policies; ethics in publication; medical ethics; open access publishing; scientific publishing; transparency
    DOI:  https://doi.org/10.1016/j.jdent.2022.104385
  63. Sci Rep. 2022 Dec 07. 12(1): 21163
      Trypophobia has attracted scientific attention in recent years. Few related studies have recruited participants using online methods, and even less is known about health communication in an environment where trypophobia was first widely discussed (i.e., the Internet). This study describes communication patterns in a Facebook group for trypophobia by detecting frequent topics, top contributors, and their discourses. We identified key commenters and performed word frequency analysis, word co-occurrence analysis, topic modeling, and content analysis. Impactful users posted and replied more often when discussing peer-reviewed science. Triggering content was actively removed by the group administrators. A wide variety of triggers not discussed in trypophobia-related literature were frequently mentioned. However, there was a lack of discussion on peer-reviewed treatments. The combination of a few expert and many supportive amateur gatekeepers willing to understand trypophobia, along with active monitoring by administrators, might contribute to in-group trust and the sharing of peer-reviewed science by top users of the trypophobia Facebook group.
    DOI:  https://doi.org/10.1038/s41598-022-25301-3
  64. Yearb Med Inform. 2022 Aug;31(1): 236-240
      OBJECTIVES: To select, present, and summarize the best papers in the field of Knowledge Representation and Management (KRM) published in 2021.METHODS: Following the International Medical Informatics Association (IMIA) Yearbook guidelines, a comprehensive and standardized review of the biomedical informatics literature was performed to select the best KRM papers published in 2021, based on PubMed queries.
    RESULTS: A total of 1,231 publications were retrieved from PubMed. We nominated 15 candidate best papers, and four of them were finally selected as the best papers in the KRM section. The topics covered by these papers include knowledge graph, ontology development, ontology alignment, and the International Classification of Diseases.
    CONCLUSION: In the KRM best paper selection for 2021, the candidate best papers covered a wider spectrum of topics compared to the last year's significant focus on ontology curation. In particular, ontology development for specific domains (e.g., Alzheimer's disease, infectious diseases, bioethics) has received the most attention.
    DOI:  https://doi.org/10.1055/s-0042-1742523