bims-evares Biomed News
on Evaluation of research
Issue of 2022–10–09
73 papers selected by
Thomas Krichel, Open Library Society
  1. The top 100 most-cited papers in pheochromocytomas and paragangliomas: A bibliometric study.
  2. Study on the fusion of sports and medicine in China from 2012 to 2021: A bibliometric analysis via CiteSpace.
  3. A bibliometric analysis of autophagy in atherosclerosis from 2012 to 2021.
  4. Research hotspot and trend analysis in the diagnosis of inflammatory bowel disease: A machine learning bibliometric analysis from 2012 to 2021.
  5. The 50 most-cited articles on temporomandibular disorders: A bibliometric analysis.
  6. Exploring the last 50 years of Indian research on the impact of coal mining using bibliometric analysis with an overview of water-related impacts.
  7. A Bibliometric Analysis of Top-Cited Journal Articles Related to Neuromodulation for Chronic Pain.
  8. A Bibliometric Analysis of Acupuncture Therapy in the Treatment of Primary Dysmenorrhea from 2001 to 2021.
  9. From past to future: Bibliometric analysis of global research productivity on nomogram (2000-2021).
  10. Research trends in college students' sleep from 2012 to 2021: A bibliometric analysis.
  11. Research hotspots and trends of chordoma: A bibliometric analysis.
  12. A bibliometric analysis of publications on burn sepsis using VOSviewer.
  13. Mapping the structure of depression biomarker research: A bibliometric analysis.
  14. Characteristics and Trends of the Most Cited Arthroplasty Articles in the Journal of Bone and Joint Surgery.
  15. Bibliometric analysis of publications on necroptosis from 2001 to 2021.
  16. Global trends in smoking cessation research from 2002 to 2021: A bibliometric and visual analysis.
  17. Predicting the number of citations of polycystic kidney disease with 100 top-cited articles since 2010: Bibliometric analysis.
  18. Trends and focuses of hantavirus researches: a global bibliometric analysis and visualization from 1980 to 2020.
  19. Research progress and hotspot of the artificial intelligence application in the ultrasound during 2011-2021: A bibliometric analysis.
  20. Authors who contributed most to the fields of hemodialysis and peritoneal dialysis since 2011 using the hT-index: Bibliometric analysis.
  21. Global Research Trends and Perspectives of Blepharoplasty: A 20-Year Bibliometric Analysis Based on Web of Science.
  22. Research focus and theme trend on fulminant myocarditis: A bibliometric analysis.
  23. Research hotspots and frontiers about role of visual perception in stroke: A bibliometric study.
  24. Bibliometric analysis for economy in COVID-19 pandemic.
  25. Harnessing hyaluronic acid for the treatment of osteoarthritis: A bibliometric analysis.
  26. Arthroscopic therapy of rotator cuff diseases: A bibliometric study of the past 2 decades (2002-2021).
  27. Non-coding RNA and hepatitis B virus-related hepatocellular carcinoma: A bibliometric analysis and systematic review.
  28. The 50 Most Cited Articles in Knee Medial Collateral Ligament Injury Research.
  29. A bibliometric analysis of the top 100 most cited papers and research trends in breast cancer related BRCA1 and BRCA2 genes.
  30. Trend of Academic Productivity in Plastic Surgery and the Impact of COVID-19: A Bibliometric Analysis.
  31. Global Scientific Research Landscape on Aluminum Toxicology.
  32. What are the trends in the treatment of multiple sclerosis in recent studies? - A bibliometric analysis with global productivity during 1980-2021.
  33. Study on Chronic Obstructive Pulmonary Disease and Lung Cancer: Web of Science-Based Bibliometric and Visual Analysis.
  34. Evolution of evidence in spinal surgery - past, present and future Scientometric analysis of randomized controlled trials in spinal surgery.
  35. Using the Sankey diagram to visualize article features on the topics of whole-exome sequencing (WES) and whole-genome sequencing (WGS) since 2012: Bibliometric analysis.
  36. One hundred most-cited articles in head and neck surgery and analysis of female authorship.
  37. Thematic trends and knowledge structure on cognitive behavior therapy for insomnia: A bibliometric and visualization analysis.
  38. Mapping the global research landscape on insulin resistance: Visualization and bibliometric analysis.
  39. Scars of COVID-19: A bibliometric analysis of post-COVID-19 fibrosis.
  40. Cerebral Small Vessel Disease: A Bibliometric Analysis.
  41. Research trends in ulcerative colitis: A bibliometric and visualized study from 2011 to 2021.
  42. Bibliometric and visualized analysis of the application of nanotechnology in glioma.
  43. Continued use of retracted papers: Temporal trends in citations and (lack of) awareness of retractions shown in citation contexts in biomedicine.
  44. Comprehensive metrological and content analysis of the income inequality research in health field: A bibliometric analysis.
  45. Research on metallic glasses at the atomic scale: a systematic review.
  46. Bibliometric-analysis visualization and review of non-invasive methods for monitoring and managing the portal hypertension.
  47. Current status and trends in researches based on public intensive care databases: A scientometric investigation.
  48. A bibliometric of research trends in acupuncture for spinal cord injury: Quantitative and qualitative analyses.
  49. A bibliometric research based on hotspots and frontier trends of denosumab.
  50. Impact factor JUMPS after the 2020 COVID-19 pandemic: a retrospective study in Dermatology journals.
  51. Impact of supervisors' research style on young biomedical scientists' capacity development as measured by REDi, a novel index of crossdisciplinarity.
  52. Exploring the frontiers of sustainable livelihoods research within grassland ecosystem: A scientometric analysis.
  53. Mapping Manuel Sandoval Vallarta (1899-1977) Scientific Contribution.
  54. Bibliometric and visual analysis of nephrotoxicity research worldwide.
  55. Most Cited Articles in 2021.
  56. Three-year trends in literature on artificial intelligence in ophthalmology and vision sciences: a protocol for bibliometric analysis.
  57. A century of research on psychedelics: A scientometric analysis on trends and knowledge maps of hallucinogens, entactogens, entheogens and dissociative drugs.
  58. Tracking Openness and Topic Evolution of COVID-19 Publications January 2020-March 2021: Comprehensive Bibliometric and Topic Modeling Analysis.
  59. Trends in diversity, equity and inclusion publications in neurological journals: 2015-2020.
  60. The Impact of Senior Author Profile on Publication Level of Evidence in Plastic and Reconstructive Surgery.
  61. Academic Health Centers' configurations, scientific productivity, and impact: Insights from the Italian setting.
  62. A review on properties, challenges and commercial aspects of eco-friendly biolubricants productions.
  63. Waste management and green technology: future trends in circular economy leading towards environmental sustainability.
  64. The positive aspects of caregiving in dementia: A scoping review and bibliometric analysis.
  65. Recent progress and research trend of anti-cataract pharmacology therapy: A bibliometric analysis and literature review.
  66. A Discussion Between Past and Present Editor-in-Chief of the International Neurourology Journal: Three Decades of History.
  67. Trends in Health Quality-Related Publications Over the Past Three Decades: Systematic Review.
  68. Spin in the Abstracts of Meta-analyses and Systematic Reviews: Midshaft Clavicle Fracture.
  69. Environmental risk, toxicity, and biodegradation of polyethylene: a review.
  70. Rehabilitation Research in Denmark Between 2001 and 2020: A Scoping Review.
  71. A decade after the first Pucciniales genomes: A bibliometric snapshot of (post) genomics studies in three model rust fungi.
  72. The clear reporting of study limitations in the reports of orthodontic randomized controlled trials is not routinely undertaken: A systematic search and review.
  73. Characteristics of Retracted Research Articles About COVID-19 vs Other Topics.
  1. Front Oncol. 2022 ;12 993921
    The top 100 most-cited papers in pheochromocytomas and paragangliomas: A bibliometric study.
    Sai-Li Duan, Lin Qi, Ming-Hao Li, Long-Fei Liu, Yong Wang, Xiao Guan.
       Background: The purpose of this study was to define and analyze the characteristics of the top 100 most-cited articles and reviews on the topic of pheochromocytomas and paragangliomas (PPGLs) by using bibliometric methods.
    Methods: We explored the Web of Science Core Collection database to gather the 100 top-cited original articles and reviews of PPGL from 1985 to 20 December 2020. We conducted a bibliometric study to identify the most influential journals, authors, countries, and institutions in the PPGL field.
    Results: The 100 top-cited papers were cited a total number of 25,723 times, ranging from 131 to 1,144 (mean, 257.23 ± 173.64). All of these 100 top-cited papers were published between 1999 and 2017, and the number of top-cited papers published before 2008 (1999-2008) was significantly higher than that after 2008 (2009-2017) (p = 0.043). The journal with the highest number of published papers is the Journal of Clinical Endocrinology & Metabolism (n = 23). The United States was the most productive country in this topic, which published about half of these publications (n = 51). The National Institutes of Health (NIH) had the largest number of publications (n = 17). Genes or genetics is still the hottest topic in the field of PPGLs.
    Conclusions: We defined and analyzed the top 100 most-cited papers in the field of PPGLs by gathering detailed information. These data provided insights into the most influential studies related to PPGL. We hoped to inspire researchers and readers in this field to improve their understanding of PPGL research trends and provide ideas for future research from unique perspectives.
    Keywords:  PPGL; bibliometric study; paragangliomas; pheochromocytomas; top 100
    DOI:  https://doi.org/10.3389/fonc.2022.993921
  2. Front Public Health. 2022 ;10 939557
    Study on the fusion of sports and medicine in China from 2012 to 2021: A bibliometric analysis via CiteSpace.
    Si-Jing Tu, Chen Jin, Bu-Tong Chen, An-Ying Xu, Chao Luo, Xiao-He Wang.
       Objective: To analyze the research hot spots and frontiers of studies on of the fusion of sports and medicine (FSM) in China in recent decade via CiteSpace.
    Methods: Relevant publications related FSM published from January 1, 2012 to December 31, 2021 were obtained from the China National Knowledge Infrastructure (CNKI) database. CiteSpace software was used to analyze the amount of publications, institutions and keywords using standard bibliometric indicators.
    Results: A total of 729 publications on FSM were identified, and 688 qualified records were included in the final analysis. Between 2012 to 2021, the number of publications showed a trend of growth, albeit with certain fluctuations. The authors of these publications were mainly from universities or colleges with sports background. The institution leading the study was the Beijing Sport University (n = 20), the most prolific (n =12) and most-cited (224 times) author was Guo JJ from Capital University of Physical Education Sports. The journal with most publications on FSM was Contemporary Sports Technology (n =74). The analysis of keywords showed that the "FSM" had the highest frequency (n = 269), "integration of sports and medicine" had the strongest citation bursts (4.82), "national fitness" had the highest centrality (0.97) in recent decade, and 15 clusters of keywords were produced by log-likelihood ratio (all silhouette value >0.9).
    Conclusion: The findings of this bibliometric study analyse the current status and trends in the FSM in China, which may help to identify hot topics, explore new study directions for scholars and policymakers in the future.
    Keywords:  CiteSpace; bibliometric analysis; data visualization; fusion of sports and medicine; health policy
    DOI:  https://doi.org/10.3389/fpubh.2022.939557
  3. Front Pharmacol. 2022 ;13 977870
    A bibliometric analysis of autophagy in atherosclerosis from 2012 to 2021.
    Fengwei Zhang, Ruirui Wang, Baocheng Liu, Lei Zhang.
      Background: Regulation of autophagy affects the progression of atherosclerosis. In recent years, research on autophagy in atherosclerosis has been widely concerned. However, there is no bibliometric analysis in this field. Objective: The purpose of this study was to explore the general situation, hot spots, and trends of the research in this field through bibliometric analysis. Methods: Articles related to autophagy in atherosclerosis from 2012 to 2021 were retrieved from the Web of Science Core Collection. VOSviewer and CiteSpace were used for data analysis and visualization of countries, institutions, authors, keywords, journals, and citations. Results: A total of 988 articles were obtained in the last 10 years. The number of publications and citations increased rapidly from 2012 to 2021, especially after 2019. The most productive countries, institutions, journals, and authors were the People's Republic of China, Shandong University, Arteriosclerosis Thrombosis and Vascular Biology, and Wim Martinet, respectively. The primary keywords were "oxidative stress," "apoptosis," "activated protein kinase," and "inflammation." The burst detection analysis of keywords found that "SIRT1" and "long non-coding RNA" might be regarded as the focus of future research. Conclusion: This is the first bibliometric analysis of autophagy in atherosclerosis, which reports the hot spots and emerging trends. The interaction between oxidative stress and autophagy, programmed cell death, and activated protein kinases are considered to be the current research priorities. Molecular mechanisms and therapeutic target for the intervention of atherosclerosis by regulating autophagy will become an emerging research direction.
    Keywords:  Atherosclerosis; Autophagy; CiteSpace; VOSviewer; bibliometric
    DOI:  https://doi.org/10.3389/fphar.2022.977870
  4. Front Immunol. 2022 ;13 972079
    Research hotspot and trend analysis in the diagnosis of inflammatory bowel disease: A machine learning bibliometric analysis from 2012 to 2021.
    Chuan Liu, Rong Yu, Jixiang Zhang, Shuchun Wei, Fumin Xue, Yingyun Guo, Pengzhan He, Lining Shang, Weiguo Dong.
       Aims: This study aimed to conduct a bibliometric analysis of the relevant literature on the diagnosis of inflammatory bowel disease (IBD), and show its current status, hot spots, and development trends.
    Methods: The literature on IBD diagnosis was acquired from the Science Citation Index Expanded of the Web of Science Core Collection. Co-occurrence and cooperation relationship analysis of authors, institutions, countries, journals, references, and keywords in the literature were carried out through CiteSpace software and the Online Analysis platform of Literature Metrology. At the same time, the relevant knowledge maps were drawn, and the keywords cluster analysis and emergence analysis were performed.
    Results: 14,742 related articles were included, showing that the number of articles in this field has increased in recent years. The results showed that PEYRIN-BIROULET L from the University Hospital of Nancy-Brabois was the author with the most cumulative number of articles. The institution with the most articles was Mayo Clin, and the United States was far ahead in the article output and had a dominant role. Keywords analysis showed that there was a total of 818 keywords, which were mainly focused on the research of related diseases caused or coexisted by IBD, such as colorectal cancer and autoimmune diseases, and the diagnosis and treatment methods of IBD. Emerging analysis showed that future research hotspots and trends might be the treatment of IBD and precision medicine.
    Conclusion: This research was the first bibliometric analysis of publications in the field of IBD diagnosis using visualization software and data information mining, and obtained the current status, hotspots, and development of this field. The future research hotspot might be the precision medicine of IBD, and the mechanism needed to be explored in depth to provide a theoretical basis for its clinical application.
    Keywords:  CiteSpace; bibliometric; diagnosis; inflammatory bowel disease; keywords; precision medicine
    DOI:  https://doi.org/10.3389/fimmu.2022.972079
  5. J Back Musculoskelet Rehabil. 2022 Sep 23.
    The 50 most-cited articles on temporomandibular disorders: A bibliometric analysis.
    Martina Ferrillo, Vittorio Gallo, Lorenzo Lippi, Alessandro Bruni, Roberta Montrella, Claudio Curci, Dario Calafiore, Marco Invernizzi, Mario Migliario, Alessandro de Sire.
       BACKGROUND: Temporomandibular disorders (TMD) are musculoskeletal conditions involving masticatory muscles and temporomandibular joints. Bibliometric analysis has been introduced as a new method for collecting and analyzing information on scientific articles.
    OBJECTIVE: The aim of this study was to identify the 50 most cited articles on TMD, performing a bibliometric analysis of the identified papers to favor research and clinical practice.
    METHODS: On December 17, 2021 a systematic research was performed to find all papers on TMD published in the literature. The Incites Journal Citation Reports dataset and Scopus database was used to obtain bibliometric indexes of the authors and metrics data of the journals, including Impact Factor, Eigenfactor Score, and Normalized Eigenfactor. VOSviewer was used to visualize the keyword mapping networking, with the nodes standing for keywords and the edges for keyword relationships.
    RESULTS: Out of 24372 papers obtained by the search strategy, the 50 most cited articles on TMD were analyzed. The paper with the highest number of citations (n= 3020) was on TMD research diagnostic criteria. Rate of citations per year collected by the 50 most cited articles on TMD has been increasing over time (from 627 in 2006 to 1483 in 2021). Most of them were cross-sectional studies (n= 20; 40.0%) and narrative reviews (n= 14; 28.0%).
    CONCLUSION: This bibliometric study showed an increasing number of citations for articles on TMD, testifying a high interest in the last years. Starting from this analysis, future studies might provide high-quality evidence on TMD management.
    Keywords:  Temporomandibular disorders; bibliometric analysis; pain; rehabilitation; temporomandibular joint disorders
    DOI:  https://doi.org/10.3233/BMR-220152
  6. Environ Sci Pollut Res Int. 2022 Oct 03.
    Exploring the last 50 years of Indian research on the impact of coal mining using bibliometric analysis with an overview of water-related impacts.
    Kumari Anjali, Renji Remesan.
      This paper throws light on the bibliometric review of the impact of coal mining in India over the past 50 years, emphasizing environmental, especially water-related impacts. The data were refined from the Web of Science database and analyzed in a bibliometric map visualization software tool, VOSviewer, to grasp the research focus, status quo and analyze the trend and direction of the work being carried out in this area. The methodology was covered in three phases: search and document selection, software and data extraction, and analysis of results and trends. The study results indicated that (i) the publication has increased in the past two decades (2001-2021) with a steep increase in the period from 2010 to 2021 with 74.68% article types documents and a mere 7.74% review documents. (ii) In India, the significant contribution is made by the Indian Institute of Technology (Indian School of Mines), Dhanbad with Department of Science and Technology as a primary funding agency. (iii) The bibliometric map of co-occurrence of author keywords showed that keywords relating to the "pollution" (connected to air, water) from "Jharia coalfield" have highest occurrences in the relevant published works of literature and topics like "reclamation," "mine spoil," and application of approaches like "remote sensing and GIS" have lower linkage strengths in general. (iv) The result of the co-citation network study has marked the most significant authors and the highly cited sources of the database revealing Ghose M.K. and Singh A.K. as among the most cited authors with citations more than 150 in the field of our interest. (v) The trend of publication in the research area of Water Resources showed a significant increase after 2015. The keyword occurrence map reveals that water quality studies have been extensively studied, but quantifications of the coal mining-induced changes in water regimes at river basin scales are absent.
    Keywords:  Bibliometric analysis; Co-citation; Co-occurrence; Coal mining; VOSviewer; Visualization; Web of Science
    DOI:  https://doi.org/10.1007/s11356-022-23381-2
  7. Neuromodulation. 2022 Sep 30. pii: S1094-7159(22)01249-1. [Epub ahead of print]
    A Bibliometric Analysis of Top-Cited Journal Articles Related to Neuromodulation for Chronic Pain.
    Eliana Ege, Collin Olevson, Ryan S D'Souza, Susan M Moeschler, Tim Lamer, Jonathan M Hagedorn.
       OBJECTIVES: Since its foundation in the 1960s, neuromodulation has become an increasingly used treatment option for chronic pain. This bibliometric analysis examines the most cited research in this field with the aim of uncovering existing trends and future directions.
    MATERIALS AND METHODS: Clarivate's Web of Science data base was searched for the top 25 most cited studies focusing on neuromodulation for chronic pain. Various bibliometric parameters were then extracted and analyzed. Randomized controlled trials (RCTs) were compared with non-RCTs.
    RESULTS: The top 25 articles had a mean of 347 citations and 22.2 citations per year, with more recent articles having a higher citation rate. Most were published in the last two decades and predominantly originated from the United States. There were 13 RCTs, which were significantly more recent (p = 0.004) and more cited per year (p = 0.001) than the 12 non-RCTs. Sources included 15 journals with a mean impact factor of 13.896. The most studied modality was spinal cord stimulation with 20 articles (76.9%), followed by intrathecal drug delivery (15.4%), dorsal root ganglion stimulation (3.8%), and peripheral nerve stimulation (3.8%).
    CONCLUSIONS: Analysis of the most cited articles on neuromodulation reveals a focal shift from historical reports to innovative RCTs that have increasingly guided pain practice in the recent years. As novel techniques and technologies continue to develop, high-quality evidence coupled with broadening indications will likely direct further expansion of this field.
    Keywords:  Bibliometric analysis; chronic pain; neuromodulation
    DOI:  https://doi.org/10.1016/j.neurom.2022.08.452
  8. J Pain Res. 2022 ;15 3043-3057
    A Bibliometric Analysis of Acupuncture Therapy in the Treatment of Primary Dysmenorrhea from 2001 to 2021.
    Daocheng Zhu, Yuanyi Xiao, Genping Zhong, Xu Wei, Jiajia Wu, Rixin Chen, Lin Jiao.
       Background: Acupuncture therapy has already extensively used in many countries around the world to treat primary dysmenorrhea. But there is no bibliometric analysis on this aspect. Therefore, the purpose of this study is to evaluate the research trends of acupuncture therapy in the treatment of primary dysmenorrhea through literature research from 2001 to 2021 by using Citespace 6.1.R1(64-bit) Basic.
    Methods: Relevant literature is extracted from the Web of Science database. CiteSpace conducts cooperative network analysis on the information of authors, countries and institutions, co-occurrence network analysis on keywords, and co-citation analysis on cited journals, cited authors and cited references.
    Results: A total of 189 publications were extracted from 2001 to 2021. The total numbers of publication have steadily increased over the past two decades, and we have identified the most active countries, institutions, journals and authors in the field of acupuncture for primary dysmenorrhea. The EVID-BASED COMPL ALT was the most productive journal, and the COCHRANE DB SYST REV with the highest IF. The first in the frequency and centrality is the journal of AM J OBSTET GYNECOL. The most productive country and institution are China and Beijing University Chinese Medicine. YANG J was the most prolific author and CHEN H had the highest citation counts. The centrality of cite references ranked the first conducted by Burnett M. The keyword of "primary dysmenorrhea" ranked first for research developments with the highest frequency.
    Conclusion: The research results of Metrology in this paper provide the current situation and trend of clinical research on primary dysmenorrhea acupuncture Therapy in recent twenty-one years, which is helpful for researchers to identify the hot spots in this field and explore new directions of future research.
    Keywords:  CiteSpace; acupuncture therapy; bibliometric analysis; primary dysmenorrhea; research trends
    DOI:  https://doi.org/10.2147/JPR.S384757
  9. Front Public Health. 2022 ;10 997713
    From past to future: Bibliometric analysis of global research productivity on nomogram (2000-2021).
    Xiaoxue Wang, Jingliang Lu, Zixuan Song, Yangzi Zhou, Tong Liu, Dandan Zhang.
       Background: Nomogram, a visual clinical predictive model, provides a scientific basis for clinical decision making. Herein, we investigated 20 years of nomogram research responses, focusing on current and future trends and analytical challenges.
    Methods: We mined data of scientific literature from the Core Collection of Web of Science, searching for the original articles with title "Nomogram*/Parton Table*/Parton Nomogram*", published within January 1st, 2000 to December 30th, 2021. Data records were validated using HistCite Version and analyzed with a transformable statistical method, the Bibliometrix 3.0 package of R Studio.
    Results: In total, 4,176 original articles written by 19,158 authors were included from 915 sources. Annually, Nomogram publications are continually produced, which have rapidly grown since 2018. China published the most articles; however, its total citations ranked second after the United States. Both total citations and average article citations in the United States rank first globally, and a high degree of cooperation exists between countries. Frontiers in Oncology published the most papers (238); this number has grown rapidly since 2019. Journal of Urology had the highest H-index, with an average increase in publications over the past 20 years. Most research topics were tumor-related, among which tumor risk prediction and prognostic evaluation were the main contents. Research on prognostic assessment is more published and advanced, while risk prediction and diagnosis have good developmental prospects. Furthermore, nomogram of the urinary system has been highly developed. Following advancements in nomogram modeling, it has recently been applied to non-oncological subjects.
    Conclusion: This bibliometric analysis provides a comprehensive overview of the current nomogram status, which could enable better understanding of its development over the years, and provide global researchers a comprehensive analysis and structured information to help identify hot spots and gaps in future research.
    Keywords:  Bibliometrix; Biblioshiny; bibliometric analysis; data mining; nomogram
    DOI:  https://doi.org/10.3389/fpubh.2022.997713
  10. Front Psychiatry. 2022 ;13 1005459
    Research trends in college students' sleep from 2012 to 2021: A bibliometric analysis.
    Jingxin Zhou, Junchao Qu, Siqi Ji, Yuan Bu, Yicheng Hu, Huiping Sun, Mengxin Xue, Ting Zhou, Jiling Qu, Yongbing Liu.
       Background: A great proportion of college students experience various sleep problems, which damage their health and study performance. College students' sleep problems, which are caused by several factors, have been easily ignored before. In the past decade, more research has been published to expand our understanding of undergraduates' sleep. The purpose of the study is to explore the research hotspots and frontiers regarding college students' sleep using CiteSpace5.8.R3 and offer guidance for future study.
    Methods: We retrieved relevant literature from the Web of Science Core Collection Database and imputed the downloaded files into CiteSpace5.8.R3 for visualization analysis. We generated network maps of the collaborations between authors, countries, institutions, the cited journals, and co-occurrence keywords. The analysis of keywords clusters, timeline views, and keywords citation bursts help us identify the hotspots and research trends.
    Results: A total of 1,841 articles related to college students' sleep, published from 2012 to 2021, were selected. The number of publications gradually increased. Karl Peltzer was the most prolific authors with 15 publications. The United States and Harvard University separately contributed 680 and 40 articles and had the greatest impact in this field. SLEEP ranked first in the frequency of cited journals. The article published by Lund HG was the most influential publication. Based on the analysis of keywords, we summarized research hotspots as follows: current status, affecting factors, and adverse outcomes of college students' sleep. The frontiers were the further understanding of the relationships between sleep and mental and physical health, and various interventions for sleep disorders.
    Conclusion: Our study illustrates the research hotspots and trends and calls for more research to expand the findings. In the future, the cooperation between institutions and authors needs to be strengthened. The complex relationships between sleep and mental and physical health and problematic substance use disorders are necessary to be explored. Longitudinal studies or randomized controlled trials should be constructed to verify the current findings or assumptions.
    Keywords:  CiteSpace; bibliometric analysis; college students; research hotspots; sleep
    DOI:  https://doi.org/10.3389/fpsyt.2022.1005459
  11. Front Oncol. 2022 ;12 946597
    Research hotspots and trends of chordoma: A bibliometric analysis.
    Jianxuan Gao, Runzhi Huang, Huabin Yin, Dianwen Song, Tong Meng.
       Background: Chordoma is a type of mesenchymal malignancy with a high recurrence rate and poor prognosis. Due to its rarity, the tumorigenic mechanism and optimal therapeutic strategy are not well known.
    Methods: All relevant articles of chordoma research from 1 January 2000 to 26 April 2022 were obtained from Web of Science Core Collection database. Blibliometrix was used to acquire basic publication data. Visualization and data table of collaboration network, dynamic analysis, trend topics, thematic map, and factorial analysis were acquired using Blibliometrix package. VOSviewer was used to generate a visualization map of co-citation analysis and co-occurrence.
    Results: A total of 2,285 articles related to chordoma were identified. The most influential and productive country/region was the United States, and Capital Medical University has published the most articles. Among all high-impact authors, Adrienne M. Flanagan had the highest average citation rate. Neurosurgery was the important periodical for chordoma research with the highest total/average citation rate. We focused on four hotspots in recent chordoma research. The research on surgical treatment and radiotherapy was relatively mature. The molecular signaling pathway, targeted therapy and immunotherapy for chordoma are not yet mature, which will be the future trends of chordoma research.
    Conclusion: This study indicates that chordoma studies are increasing. Surgery and radiotherapy are well reported and always play fundamental roles in chordoma treatment. The molecular signaling pathway, targeted therapy, and immunotherapy of chordoma are the latest research hotspots.
    Keywords:  bibliometric analysis; chordoma; hotspots; treatment; tumorigenesis
    DOI:  https://doi.org/10.3389/fonc.2022.946597
  12. Front Med (Lausanne). 2022 ;9 971393
    A bibliometric analysis of publications on burn sepsis using VOSviewer.
    Zhi Cao, Yu Zhang, Jin-Hua Luo, Wen-Qiang Liao, Xing Cheng, Jian-Hua Zhan.
       Background: Sepsis is one of the most common complications in burn patients and causes high morbidity, especially in those with severe burns. Nevertheless, there are no formal criteria for diagnosing and treating burn sepsis. Therefore, this bibliometric analysis is applied to reveal research trends in this field and predicts its possible hot spots.
    Methods: We screened relevant literature on burn sepsis that met the inclusion criteria of the Web of Sciences (WOS) database and analyzed publication trends and research hot spots in related fields using VOSviewer software.
    Results: From 1981 to 2022, we screened 2,486 documents that met the requirements and analyzed them bibliometrically. The American scholar Herndon DN had a much higher h-index [47] than other authors. Most published, cited, and h-indexed publications are from the USA (Np: 1193, Nc: 42154, H: 98). The second most publishing country is China, but the second most cited and h-indexed country is Germany. Burns also outperforms other journals in this field (Np: 376, Nc: 8019, H: 46). "Biomarkers" is a newly emerging keyword (cluster "clinical research," APY was 2018.16), and clinically relevant research in burn sepsis maybe a future research trend.
    Conclusions: Sepsis in burn patients has unique pathophysiological characteristics and the general diagnostic criteria for sepsis lack specificity. Consequently, we must establish a database and construct an intelligent predictive model to help achieve a more individualized and precise early diagnosis and treatment of burn sepsis. This may also be an important development direction for future research in this field.
    Keywords:  VOSviewer; Web of Science; bibliometric analysis; burn sepsis; direction
    DOI:  https://doi.org/10.3389/fmed.2022.971393
  13. Front Psychiatry. 2022 ;13 943996
    Mapping the structure of depression biomarker research: A bibliometric analysis.
    Xiang-Jie Guo, Peng Wu, Xiao Jia, Yi-Ming Dong, Chun-Mei Zhao, Nian-Nian Chen, Zhi-Yong Zhang, Yu-Ting Miao, Ke-Ming Yun, Cai-Rong Gao, Yan Ren.
       Background: Depression is a common mental disorder and the diagnosis is still based on the descriptions of symptoms. Biomarkers can reveal disease characteristics for diagnosis, prognosis, and treatment. In recent years, many biomarkers relevant to the mechanisms of depression have been identified. This study uses bibliometric methods and visualization tools to analyse the literature on depression biomarkers and its hot topics, and research frontiers to provide references for future research.
    Methods: Scientific publications related to depression biomarkers published between 2009 and 2022 were obtained from the Web of Science database. The BICOMB software was used to extract high-frequency keywords and to construct binary word-document and co-word matrices. gCLUTO was used for bicluster and visual analyses of high-frequency keywords. Further graphical visualizations were generated using R, CiteSpace and VOSviewer software.
    Results: A total of 14,403 articles related to depression biomarkers were identified. The United States (34.81%) and China (15.68%), which together account for more than half of all publications, can be considered the research base for the field. Among institutions, the University of California, University of London, and Harvard University are among the top in terms of publication number. Three authors (Maes M, Penninx B.W.J.H., and Berk M) emerged as eminent researchers in the field. Finally, eight research hotspots for depression biomarkers were identified using reference co-citation analysis.
    Conclusion: This study used bibliometric methods to characterize the body of literature and subject knowledge in the field of depression biomarker research. Among the core biomarkers of depression, functional magnetic resonance imaging (fMRI), cytokines, and oxidative stress are relatively well established; however, research on machine learning, metabolomics, and microRNAs holds potential for future development. We found "microRNAs" and "gut microbiota" to be the most recent burst terms in the study of depression biomarkers and the likely frontiers of future research.
    Keywords:  bibliometric analysis; biomarker; co-citation analysis; co-word analysis; depression
    DOI:  https://doi.org/10.3389/fpsyt.2022.943996
  14. Orthop Rev (Pavia). 2022 ;14(4): 38437
    Characteristics and Trends of the Most Cited Arthroplasty Articles in the Journal of Bone and Joint Surgery.
    Jonathan Weinerman, Joseph P Costello, Juan J Lizardi, David S Constantinescu, Suleiman Y Sudah, Alexander Kuczmarski, Jaime Carvajal Alba.
       Introduction: The Journal of Bone and Joint Surgery (JBJS) is one of most influential orthopaedic journals, with Total Joint Replacements (TJR) being a frequent topic. The importance of TJR research parallels it's high prevalence in American society.
    Objective: To compile and analyze the top 50 most frequently cited articles published in the Journal of Bone and Joint Surgery regarding total joint reconstruction or arthroplasty.
    Methods: Guidelines set by the Preferred Reporting Items for Systematic Reviews were used as the foundation for data collection and analysis. Scopus database was used to acquire the metric analyzed in the study. Data was then exported to an excel sheet for analysis.
    Results: The top 50 TJR publications analyzed for this study were cited a total of 35,850 times (including self-citations), with an average number of citations per article of 717. Kurtz and Neer II were the only authors contributing more than one. 38 of 50 articles analyzed met the criteria for Level II or III in terms of Level of Evidence (LOE). The United States contributed the most publications with a total of 34. Harvard University and Massachusetts General Hospital, with eight publications each, were the highest contributing institutions.
    Conclusion: The Journal of Bone and Joint Surgery has published very influential research papers as noted by the number of citations amassed by its most popular articles. JBJS's top cited publications hail largely from major institutions in the United States and are composed of high-quality reports of mostly Level 2 and Level 3 evidence classifications.
    Level of Evidence: 3.
    Keywords:  Bibliometric Review; JBJS; Journal of Bone and Joint Surgery
    DOI:  https://doi.org/10.52965/001c.38437
  15. Front Cell Dev Biol. 2022 ;10 946363
    Bibliometric analysis of publications on necroptosis from 2001 to 2021.
    Yang Liu, Xiaojiang Zhou, Fangfei Wang, Cong Liu, Jun Xie, Le Guan, Yong Xie.
      Background: Necroptosis plays an important role in inflammation, cancer, and neurodegenerative diseases. In recent years, the number of studies related to necroptosis has increased and research has become increasingly in-depth. This study aimed to summarize the research conducted since 2001 to discover hotspots and trends in the field of necroptosis. Methods: The Web of Science Core database was used to identify global publications on necroptosis from 2001 to 2021. Bibliometric analysis was performed using Rstudio, VOSviewer, and CiteSpace. Results: The number of publications related to necroptosis gradually increased from 2001 to 2021. Vandenabeele P had the most publications at 45. Yuan JY had the most citations at 5,901. Necroptosis research has been dominated by China and Chinese institutions. Cell Death and Disease had the highest number of related publications among the examined journals. Seven of the top 10 most cited papers had more than 500 citations. Necroptosis, cell death, autophagy, injury, cancer, activated B cell nuclear factor kappa-light chain enhancer, and oxidative stress were important keywords in keyword analysis. Recent research has increasingly focused on breast cancer, receptor-interacting serine/threonine protein kinase 1, modulation, pseudokinase mixed lineage kinase domain-like protein, membrane, protection, and cycle. Conclusion: Interest in necroptosis-related research continues to increase steadily, and there is close cooperation between countries and institutions in the field of necroptosis. The study of necroptosis-related molecules and mechanisms, and the relationship between necroptosis and cancer, may be hotspots and directions in future research.
    Keywords:  bibliometric analysis; cancer; hotspot; necroptosis; trend
    DOI:  https://doi.org/10.3389/fcell.2022.946363
  16. Prev Med Rep. 2022 Dec;30 101991
    Global trends in smoking cessation research from 2002 to 2021: A bibliometric and visual analysis.
    Yingxin Xu, Zhengmin Gu, Ye Zhang, Miao He, Ben S Gerber, Rajani S Sadasivam, Feifan Liu, Zhongqing Wang.
      This study aimed to analyze the scientific outputs of smoking cessation research and explore its hotspots and frontiers from 2002 to 2021, using bibliometric methods. We use the core collection of Web of Science as a data source, and apply bibliometric methods to visually analyze articles published in smoking cessation research from 2002 to 2021, including publication year, countries/regions, journals, authors, institutions, and keywords. The VOSviewer (1.6.16) tool was used for the analysis. A total of 8797 articles related to smoking cessation research were identified. The USA was the leading contributor with 4671 publications. NICOTINE＆TOBACCO RESEARCH contributed the most publications (528), with the most citations (13746) and the highest H-index (59). The most contributing institutions were the University College London and University of California San Francisco. Robert West was most productive author. We found active collaborations among both productive authors and productive institutions. There were five hot topics in smoking cessation research: (1) Public health harm from tobacco; (2) The role of e-health in smoking cessation; (3) Role of primary health care in eliminating tobacco dependence; (4) Nicotine replacement therapy and pharmacotherapy; (5) The biological and clinical understanding of addiction. Our current study showed a growing trend in smoking cessation based on the number of published articles over the last 20 years. There was active cooperation between institutions, and authors. Electronic cigarettes, mHealth, eHealth, public health and mental health are foci of new and emerging research.
    Keywords:  Bibliometric analysis; Smoking; Smoking cessation; Tobacco; VOSviewers
    DOI:  https://doi.org/10.1016/j.pmedr.2022.101991
  17. Medicine (Baltimore). 2022 Sep 23. 101(38): e30632
    Predicting the number of citations of polycystic kidney disease with 100 top-cited articles since 2010: Bibliometric analysis.
    Chen-Yu Wang, Tsair-Wei Chien, Willy Chou, Hsien-Yi Wang.
       BACKGROUND: Polycystic kidney disease (PKD) is a genetic disorder in which the renal tubules become structurally abnormal, resulting in the development and growth of multiple cysts within the kidneys. Numerous studies on PKD have been published in the literature. However, no such articles used medical subject headings (MeSH terms) to predict the number of article citations. This study aimed to predict the number of article citations using 100 top-cited PKD articles (T100PKDs) and dissect the characteristics of influential authors and affiliated counties since 2010.
    METHODS: We searched the PubMed Central® (PMC) database and downloaded 100PKDs from 2010. Citation analysis was performed to compare the dominant countries and authors using social network analysis (SNA). MeSh terms were analyzed by referring to their citations in articles and used to predict the number of article citations using its correlation coefficients (CC) to examine the prediction effect.
    RESULTS: We observed that the top 3 countries and journals in 100PKDs were the US (65%), Netherlands (7%), France (5%), J Am Soc Nephrol (21%), Clin J Am Soc Nephrol (8%), and N Engl J Med (6%); the most cited article (PMID = 23121377 with 473 citations) was authored by Vicente Torres from the US in 2012; and the most influential MeSH terms were drug therapy (3087.2), genetics (2997.83), and therapeutic use (2760.7). MeSH terms were evident in the prediction power of the number of article citations (CC = 0.37; t = 3.92; P < .01, n = 100).
    CONCLUSIONS: A breakthrough was made by developing a method using MeSH terms to predict the number of article citations based on 100PKDs. MeSH terms are evident in predicting article citations that can be applied to future research, not limited to PKD, as we did in this study.
    DOI:  https://doi.org/10.1097/MD.0000000000030632
  18. Arch Public Health. 2022 Oct 01. 80(1): 218
    Trends and focuses of hantavirus researches: a global bibliometric analysis and visualization from 1980 to 2020.
    Xiao Wei, Xinlou Li, Shuxuan Song, Xiaohui Wen, Tiezhi Jin, Chenxi Zhao, Xubin Wu, Kun Liu, Zhongjun Shao.
       BACKGROUND: There have been worldwide changes in the researches on hantaviruses in the past several decades. Nevertheless, there are few bibliometric analysis studies this field. We aim to evaluate and visualize the research focuses and trends of this field using a bibliometric analysis way to help understand the developmet and future hotspots of this field.
    MATERIAL AND METHODS: Publications related to hantavirus studies were culled from the Web of Science Core Collection to generate trend analysis. The articles and reviews were re-extracted and Countries, institutions, authors, references and keywords in this field were visually analyzed by using VOSviewer and CiteSpace.
    RESULTS: A total of 4408 studies were included and the number of publications regarding hantaviruses significantly increased yearly. Three thousand seven hundred sixteen research articles and reviews were retrieved to generate bibliometric analysis. These studies mainly come from 125 countries led by USA and China and 3312 institutions led by the University of Helsinki. Twelve thousand five hundred twenty nine authors were identified and Vaheri A were the most influential author. Journal of Virology was the journal with the most studies and citations. After analysis, Hemorrhagic fever with renal syndrome, Hantavirus cardiopulmonary syndrome, nephropathia epidemica and related genotypes, clinical symptoms and rodents were the most common keywords and developing areas.
    CONCLUSION: Research on hantavirus is flourishing. Cooperation among different countries and institutions in this field must be strengthened in the future. The ecology and clinical symptoms of new genotypes, the vaccine development and factors that affect host population distribution and density are current and developing areas of study.
    Keywords:  Bibliometric analysis; Hantavirus; Hot topics; Research trends; VOSviewer
    DOI:  https://doi.org/10.1186/s13690-022-00973-5
  19. Front Public Health. 2022 ;10 990708
    Research progress and hotspot of the artificial intelligence application in the ultrasound during 2011-2021: A bibliometric analysis.
    Demeng Xia, Gaoqi Chen, Kaiwen Wu, Mengxin Yu, Zhentao Zhang, Yixian Lu, Lisha Xu, Yin Wang.
      Ultrasound, as a common clinical examination tool, inevitably has human errors due to the limitations of manual operation. Artificial intelligence is an advanced computer program that can solve this problem. Therefore, the relevant literature on the application of artificial intelligence in the ultrasonic field from 2011 to 2021 was screened by authors from the Web of Science Core Collection, which aims to summarize the trend of artificial intelligence application in the field of ultrasound, meanwhile, visualize and predict research hotspots. A total of 908 publications were included in the study. Overall, the number of global publications is on the rise, and studies on the application of artificial intelligence in the field of ultrasound continue to increase. China has made the largest contribution in this field. In terms of institutions, Fudan University has the most number of publications. Recently, IEEE Access is the most published journal. Suri J. S. published most of the articles and had the highest number of citations in this field (29 articles). It's worth noting that, convolutional neural networks (CNN), as a kind of deep learning algorithm, was considered to bring better image analysis and processing ability in recent most-cited articles. According to the analysis of keywords, the latest keyword is "COVID-19" (2020.8). The co-occurrence analysis of keywords by VOSviewer visually presented four clusters which consisted of "deep learning," "machine learning," "application in the field of visceral organs," and "application in the field of cardiovascular". The latest hot words of these clusters were "COVID-19; neural-network; hepatocellular carcinoma; atherosclerotic plaques". This study reveals the importance of multi-institutional and multi-field collaboration in promoting research progress.
    Keywords:  CNN; COVID-19; artificial intelligence; bibliometrics; ultrasound
    DOI:  https://doi.org/10.3389/fpubh.2022.990708
  20. Medicine (Baltimore). 2022 Sep 23. 101(38): e30375
    Authors who contributed most to the fields of hemodialysis and peritoneal dialysis since 2011 using the hT-index: Bibliometric analysis.
    Hsien-Yi Wang, Tsair-Wei Chien, Wei-Chih Kan, Chen-Yu Wang, Willy Chou.
       BACKGROUND: The h-index does not take into account the full citation list of a researcher to evaluate individual research achievements (IRAs). As a generalization of the h-index, the hT-index takes all citations into account to evaluate IRAs. Compared to other bibliometric indices, it is unclear whether the hT-index is more closely associated with the h-index. We utilized articles published on hemodialysis and peritoneal dialysis (HD/PD) to validate the hT-index as a measure of the most significant contributions to HD/PD.
    METHODS: Using keywords involving HD/PD in titles, subject areas, and abstracts since 2011, we obtained 7702 abstracts and their associated metadata (e.g., citations, authors, research institutes, countries of origin). In total, 4752 first or corresponding authors with hT-indices >0 were evaluated. To present the author's IRA, the following 4 visualizations were used: radar, Sankey, impact beam plot, and choropleth map to investigate whether the hT-index was more closely associated with the h-index than other indices (e.g., g-/x-indices and author impact factors), whether the United States still dominates the majority of publications concerning PD/HD, and whether there was any difference in research features between 2 prolific authors.
    RESULTS: In HD/PD articles, we observed that (a) the hT-index was closer to and associated with the h-index; (b1) the United States (37.15), China (34.63), and Japan (28.09) had the highest hT-index; (b2) Sun Yat Sen University (Chian) earned the highest hT-index (=20.02) among research institutes; (c1) the authors with the highest hT-indices (=15.64 and 14.39, respectively) were David W Johnson (Australia) and Andrew Davenport (UK); and (c2) their research focuses on PD and HD, respectively.
    CONCLUSION: The hT-index was demonstrated to be appropriate for assessing IRAs along with visualizations. The hT-index is recommended in future bibliometric analyses of IRAs as a complement to the h-index.
    DOI:  https://doi.org/10.1097/MD.0000000000030375
  21. Aesthetic Plast Surg. 2022 Oct 06.
    Global Research Trends and Perspectives of Blepharoplasty: A 20-Year Bibliometric Analysis Based on Web of Science.
    Hong Gao, Dan Wu, Xiang Jie, ZheYuan Hu, WenJun Zhang, Lie Zhu, XiaoHai Zhu.
       BACKGROUND: The number of publications on blepharoplasty is increasing rapidly. Bibliometric analysis can help surgeons quickly and systematically understand the current state of development. To our knowledge, there are no bibliometric studies on blepharoplasty, and therefore, we conducted this study to reveal research trends and perspectives of blepharoplasty.
    METHODS: Relevant publications from 2002 to 2021 were extracted from the Web of Science Core Collection database. After manual screening, VOSviewer software and CiteSpace software were used to collect and analyze the acquired data.
    RESULTS: A total of 1125 publications were included and the publications per year increased annually. Contributions from the USA led both quantity and quality. The University of California System was one of the most influential academic institutions. Aesthetic Plastic Surgery had the most publications, and Plastic and Reconstructive Surgery was the most frequently cited or co-cited journal. Massry GG and Hamra ST were the most prolific and co-cited authors, respectively. Additionally, Rohrich RJ had the highest number of citations per publication. References co-cited analysis identified that lower eyelid research was a hotspot. Keywords were mainly divided into 6 clusters, namely "lower lid blepharoplasty," "complications," "facial rejuvenation," "blepharoptosis," "upper blepharoplasty," and "Asian blepharoplasty and epicanthoplasty."
    CONCLUSIONS: Blepharoplasty research is flourishing, and three clusters may be the hotspots: "Lower blepharoplasty and mid-face rejuvenation," "overall facial outcome and quality-of-life," and "Asian blepharoplasty and epicanthoplasty."
    LEVEL OF EVIDENCE III: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
    Keywords:  Bibliometric analysis; Blepharoplasty; Lower blepharoplasty
    DOI:  https://doi.org/10.1007/s00266-022-03116-x
  22. Front Cardiovasc Med. 2022 ;9 935073
    Research focus and theme trend on fulminant myocarditis: A bibliometric analysis.
    Weimei Yang, Xifei He, Zhaozhao Wang, Lijuan Lu, Ge Zhou, Jie Cheng, Xinying Hao.
       Aims: This study intends to explore the research focus and trends of fulminant myocarditis (FM) to have a better understanding of the topic.
    Materials and methods: The data were downloaded from the Web of Science (WoS) database using the topic (TS) advanced search strategy. Many instruments were used to extract, analyze, and visualize the data, such as Microsoft Excel, HistCite Pro, GunnMap, BibExcel, and VOSviewer.
    Results: From 1985 to 2022, 726 documents were indexed in the WoS. The United States and Columbia University were the most productive country and institutions. Keywords co-occurrence was carried out and four research themes were identified. In addition, the top three prolific authors, the first three highly cited authors, and the core authors of the author co-citation network were identified. The topics that they kept an eye on were analyzed, and the research areas of key authors were similar to the results of keyword co-occurrence. The hot topics of FM were related to the mechanical circulatory support, etiology, diagnosis, and the disease or therapy associated with FM.
    Conclusion: This study carried out a systematic analysis of the documents related to FM from 1985 to 2022, which can provide a guideline for researchers to understand the theme trend to promote future research to be carried out.
    Keywords:  bibliometric analysis; citation network; fulminant myocarditis (FM); research focus; theme trends
    DOI:  https://doi.org/10.3389/fcvm.2022.935073
  23. Front Neurol. 2022 ;13 958875
    Research hotspots and frontiers about role of visual perception in stroke: A bibliometric study.
    Nannan Zhang, Chong Li, Jianmin Chen, Xiahua Liu, Zhiyong Wang, Jun Ni.
       Background: Visual perception is a dynamic process of perceiving the environment through sensory input and transforming sensory input into meaningful concepts related to environmental visual knowledge. Many studies focusing on the role of visual perception after stroke have been published in various journals. However, a bibliometric analysis in the domain of visual perception after stroke is still lacking. This study aimed to deliver a visual analysis to analyze the global trends in research on the role of visual perception after stroke in the last 10 years.
    Methods: The literature was derived from the Web of Science core collection database from 2012 to 2021. The collected material was limited to English articles and reviews. CiteSpace and Microsoft Excel were used for bibliographic analysis.
    Results: A total of 298 articles were included in the analysis. The annual number of publications increased from 23 to 42 in the last decade. Rehabilitation was the main research hotspot (n = 85). Journal of Physical Therapy Science published the largest number of papers (n = 14). The most influential author, institution, and country were Rowe FJ (n = 17), League of European Research Universities (n = 45), and England (n = 54), respectively. The keywords with the longest burst period are field defect, hemineglect, disorder, and quality of life.
    Conclusion: This study analyzes the papers on the role of visual perception after stroke in the past 10 years and provides a new perspective for research in this field. At present, the number of articles in this field is not large and the cooperation network is not close enough. In the future, it is necessary to strengthen the cooperation among various countries, institutions, and authors. In addition, large samples and randomized controlled trials are needed to identify the potential treatments and pathophysiology for visual perceptual impairment after stroke.
    Keywords:  CiteSpace; bibliometric; stroke; visual analysis; visual perception
    DOI:  https://doi.org/10.3389/fneur.2022.958875
  24. Heliyon. 2022 Sep;8(9): e10757
    Bibliometric analysis for economy in COVID-19 pandemic.
    Meihui Zhong, Mingwei Lin.
      Since the outbreak of COVID-19, various fields have been damaged to varying degrees, especially in the economic field. According to a comprehensive study of bibliometrics and content analysis, this paper aims at summarizing studies related to the development of the economic field during the COVID-19 epidemic. We search in Web of Science Core Collection using the subjects such as "economics", "economy", "economic", "financial", and then 2274 related documents are collected, which are published from 2020 to 2022. First, this paper uses the mixed qualitative and quantitative analysis methods to analyze the publication status of the countries, institutions, and authors, respectively, and conducts the document co-citation analysis by CiteSpace software. The results showed that the most popular journal is Sustainability, and the most productive research institutions, countries, and authors are primarily located in North American and European countries. Then, it makes an in-depth study of the cooperative network. With the support of Gephi software, this paper employs the social network analysis method to analyze the situation of the country/region cooperation and institutional cooperation. Finally, the content analysis of the related studies is presented to further explore the current challenges. On this basis, this paper analyzes the economic development in the post-epidemic era and draws some conclusions, which provide some references for scholars interested in this field.
    Keywords:  Bibliometric analysis; COVID-19; Content analysis; Economy
    DOI:  https://doi.org/10.1016/j.heliyon.2022.e10757
  25. Front Bioeng Biotechnol. 2022 ;10 961459
    Harnessing hyaluronic acid for the treatment of osteoarthritis: A bibliometric analysis.
    Jun Zhang, Miaoyuan Lin, Yanran Huang, Yuping Wang, Tianji Huang, Zhillin Wu, Zefang Li, Jingtao Xu, Runhan Zhao, Xiaoji Luo.
      Background: Osteoarthritis (OA) is a common disease which usually occurs in middle-aged and elderly people. Hyaluronic acid (HA) has been widely used to treat OA and related researches on the efficacy and safety of HA in the treatment of OA have been published. Therefore, the purpose of this research was to investigate the subject characteristics of harnessing HA for the treatment of OA and to analyse the relevant trends and hotspots by using a bibliometric approach. Methods: The articles published from 1 January 2002 to 31 December 2021 were searched in the Web of Science Core Collection (WoSCC) and the relevant information of HA for the treatment of OA was extracted after screening. Then, a total of 2438 publications were analysed by using Microsoft Excel, CiteSpace 5.8.R3, VOSviewer 1.6.18 and the Online Analysis Platform of Literature Metrology (http://bibliometric.com/). Results: A total of 2438 articles were finally included for analysis. The number of publications increased year by year. A total of 83 coutries and 3319 institutions published 2438 manuscripts in the field of use HA for the treatment of OA. The most productive country was United States with total 689 publications and League of European Research Universities Leru (Belgium) was the leading institution with total 126 publicatios. In terms of authors, the most prominent author was KrausVB, who published 28 papers with the highest H-index (19). In addition, Osteoarthritis and Cartilage had the highest number of publications (152 articles) and the highest number of citations (6450 citations). The co-cited references analysis indicated that the article published by McAlindon in 2014 had the most highest number of citations (91co-citations). What's more, most research hotspots focused on the efficacy and safety of HA, and regenerative medicine researches such as platelet-rich plasma (PRP) and mesenchymal stem cells (MSCs) have attracted more and more attentions of researchers. Conclusion: This study visually analyzed the historical evolution and future trends of HA for the treatment of OA, and discussed the research priorities. At present, there are still different views on the efficacy of HA for the treatment of OA. Gradually, research hotspots of this field have focused on the regenerative medicine.
    Keywords:  Bibliometrics; HA; Hyaluranic acid; OA; Osteoarthritis
    DOI:  https://doi.org/10.3389/fbioe.2022.961459
  26. Front Surg. 2022 ;9 927638
    Arthroscopic therapy of rotator cuff diseases: A bibliometric study of the past 2 decades (2002-2021).
    Hongfu Jin, Yilan Ding, Weiyang Wang, Ruixi Ye, Miao He, Wenqing Xie, Hengzhen Li, Wenfeng Xiao, Yusheng Li.
       Purpose: Rotator cuff diseases, as a common cause of shoulder pain and disability, have seriously affected the patients' daily life. Rotator cuff repair techniques have been a hot topic in the arthroscopic therapy field. Our study was to use bibliometrics analysis to clarify the current status and research trends in the field of arthroscopic therapy of rotator cuff diseases.
    Methods: The publications relating to arthroscopic therapy of rotator cuff diseases published from 2001 to 2021 were obtained from the Web of Science Core Collection (WoSCC) database. The R software and VOSviewer software were used for the cross-sectional bibliometric and scientometric analysis.
    Results: A total of 4,567 publications about arthroscopic therapy of rotator cuff diseases published between 2002 and 2021 retrieved from the WoSCC database were analyzed in our study. The results showed that the United States made the largest contribution to this field. The most relevant institutions were Seoul National University, Rush University, and Hospital for Special Surgery. Stephen S Burkhart was the most relevant researcher in this field with the largest number of publications, as well as the highest H-index and G-index. The journal ARTHROSCOPY contributed the largest number of publications in the past 2 decades. Considering the H-index and G-index, ARTHROSCOPY was also the journal with the largest impact in this field.
    Conclusions: Arthroscopic Therapy of Rotator Cuff Diseases Related research presented a rising trend in the past 2 decades. The United States can be regarded as the leader because of its huge contributions to this field. The journal ARTHROSCOPY published the largest number of publications in this field. It can be predicted that research about advanced arthroscopic techniques and postoperative pain management of patients with rotator cuff diseases will be the next research hotspots in the following years.
    Keywords:  arthroscopic therapy; arthroscopy; bibliometric analysis; rotator cuff diseases; web of science
    DOI:  https://doi.org/10.3389/fsurg.2022.927638
  27. Front Med (Lausanne). 2022 ;9 995943
    Non-coding RNA and hepatitis B virus-related hepatocellular carcinoma: A bibliometric analysis and systematic review.
    Li-Rong Yan, Ao-Ran Liu, Li-Yue Jiang, Ben-Gang Wang.
       Objectives: A bibliometric analysis for non-coding RNA and hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) was performed to describe international research status and visualize the research scope and emerging trends over the last two decades on this topic.
    Materials and methods: Research data of non-coding RNA and HBV-related HCC were retrieved and extracted from the Web of Science Core Collection (WoSCC) database from 1 January 2003 to 13 June 2022 and then analyzed by means of bibliometric methods. A total of 1,036 articles published in this field were assessed for specific characteristics, including the year of publication, journal, author, institution, country/region, references, and keywords. VOSviewer was employed to perform co-authorship, co-occurrence, and co-citation analyses accompanied by constructing a visual network.
    Results: Overall, 1,036 reports on non-coding RNA and HBV-related HCC from 2003 to 2022 were retrieved from WoSCC. The publication has gradually increased during the last two decades with 324 journals involved. Most research records (748 publications and 23,184 citations) were concentrated in China. A co-occurrence cluster analysis for the top 100 keywords was performed and four clusters were generated: (1) non-coding RNA as a molecular marker for the diagnosis and prognosis of HBV-related HCC; (2) dysregulation of non-coding RNA by hepatitis B virus X protein (HBx); (3) non-coding RNA affecting the biological behaviors of HBV-related HCC; and (4) epidemiological study for the effects of non-coding RNA on the risk of HBV-related HCC.
    Conclusion: The publications and citations involved in non-coding RNA and HBV-related HCC have increased over the last two decades associated with many countries, institutions, and authors. Our study revealed current development trends, global cooperation models, basic knowledge, research hotspots, and emerging frontiers in this field.
    Keywords:  HBV-related hepatocellular carcinoma; bibliometric analysis; long noncoding RNA (LncRNA); microRNA (miRNA); non-coding RNA
    DOI:  https://doi.org/10.3389/fmed.2022.995943
  28. Orthop J Sports Med. 2022 Sep;10(9): 23259671221124575
    The 50 Most Cited Articles in Knee Medial Collateral Ligament Injury Research.
    Dylan Luxenburg, Henson Destine, Michael G Rizzo, David Constantinescu, Miriyam Ghali, Lee D Kaplan, Michael G Baraga.
       Background: Medial collateral ligament (MCL) injury is a common orthopaedic knee injury with a plethora of published articles regarding evaluation, treatment, and outcome.
    Purpose: To perform a comprehensive bibliometric analysis of the 50 most cited articles in MCL research.
    Study Design: Cross-sectional study.
    Methods: We performed a keyword search of the Institute for Scientific Information's Web of Knowledge database for the identification of articles published before September 2021 encompassing the MCL. The conducted search yielded 9534 articles. The results were then filtered using predetermined guidelines and criteria, and the 50 most cited articles were selected for analysis. Extracted data included title, authors, citation count, year of publication, topic, journal, article type, country of origin, and level of evidence.
    Results: The selected 50 articles ranged from 1976 to 2013. The largest proportion was classified as having level 4 evidence (n = 12; 24%). The majority of the articles were published in the decade from 2000 to 2009 (n = 17; 34%), followed by 1990 to 1999 (n = 16; 32%). The mean raw citation score per article was 133 (range, 74-422). The most popular topic discussed was surgical technique and outcome (n = 14; 28%), followed by anatomy and biomechanics (n = 13; 26%).
    Conclusion: This study provides a comprehensive and objective measure of the most cited articles on MCL research. Knowledge of the characteristics of these most influential articles improves the understanding of MCL injury and can guide discussion for future research.
    Keywords:  MCL injury; analysis; bibliometric; citation; medial collateral ligament
    DOI:  https://doi.org/10.1177/23259671221124575
  29. Medicine (Baltimore). 2022 Sep 23. 101(38): e30576
    A bibliometric analysis of the top 100 most cited papers and research trends in breast cancer related BRCA1 and BRCA2 genes.
    Shadi Alkhayyat, Muhammad Khan, Tauseef Ahmad, Haroon, Huma Tariq, Mukhtiar Baig.
      This study aimed to identify, characterize, and map the important attributes of the top 100 most cited papers on BRCA1 and BRCA2 genes. The scientific literature on BRCA1 and BRCA2 was searched in the Web of Science Core Collection database using the keywords "BRCA1" OR "BRCA2" (Title). The top 100 most cited papers were selected based on citations. The obtained data were exported into HistCiteTM, RStudio, and VOSviewer software for prerequisite analysis. The top 100 most cited papers on BRCA1 and BRCA2 were authored by 932 authors from 24 countries and published in 27 journals. These papers were cited 79,713 times, ranging from 441 to 4671 citations. The highly cited paper was cited 4671 times and published in Science (1994). The leading author, journal, publication year, institution, and country were Easton DF (n = 16), Nature Genetics (n = 11), 2002 (n = 11), University of Pennsylvania (n = 17), and the USA (n = 76), respectively. The results show that all the top 100 papers were produced in developed countries. The collaboration index among the authors was 9.49. The most frequently appeared keywords were ovarian-cancer, breast-cancer, mutations, gene, and familial breast. In recent times, the trend topics were patients, mutations, carriers, ovarian, and risk.
    DOI:  https://doi.org/10.1097/MD.0000000000030576
  30. J Craniofac Surg. 2022 Oct 03.
    Trend of Academic Productivity in Plastic Surgery and the Impact of COVID-19: A Bibliometric Analysis.
    Kexin Che, Keke Wang, Ye Yuan, Zhen Zhang, Fengyong Li, Qiang Li.
       BACKGROUND: Plastic surgery has grown rapidly over the past decade, with increasing scientific output. The emergence of coronavirus disease 2019 (COVID-19) has a considerable impact on plastic surgery.
    OBJECTIVE: To identify trends in published literature in plastic surgery from 2011 to 2021. To explore the impact of COVID-19 on scientific research output through bibliometric analysis methods.
    METHODS: Web of Science was searched by authors on December 23, 2021. Published papers about plastic surgery over the last decade were analyzed. The search output was imported into VOSviewer for science mapping.
    RESULTS: The actual number of papers related to plastic surgery during the COVID-19 period was higher than expected one. For scientific outputs in plastic surgery, keywords about surgical practice had a high frequency. "Reconstruction," "effect," "flap," "tissue," "defect," "model" maintained a high level of heat before and after COVID-19. The heat of "risk," "complication," "review," "infection," "cohort," and "meta-analysis" increased after the outbreak of COVID-19. The international collaboration showed an upward trend despite the impact of COVID-19. From the perspective of the volume of plastic surgery publications, some journals had a more positive performance compared to the pre-epidemic period. The proportion of original articles decreased after the spread of COVID-19 from 70.26% to 63.84%.
    CONCLUSION: Although the COVID-19 has a profound impact on the healthcare industry, the bibliographic data reveals an increasing scientific output in the field of plastic surgery over time. For plastic surgery, high-frequency terms, research hotspots, popular journals, article types, and international collaboration have changed under the influence of COVID-19.
    DOI:  https://doi.org/10.1097/SCS.0000000000009021
  31. Biol Trace Elem Res. 2022 Oct 03.
    Global Scientific Research Landscape on Aluminum Toxicology.
    Weslley Ferreira de Lima, Yago Gecy Sousa Né, Walessa Alana Bragança Aragão, Luciana Eiró-Quirino, Daiane Claydes Baia-da-Silva, Ana Cirovic, Aleksandar Cirovic, Rafael Rodrigues Lima.
      This study aimed to identify the landscape of current aluminum toxicity based on knowledge mapping of the 100 most-cited articles on toxicological aspects of aluminum in biological organisms. The research was searched in the Web of Science Core Collection (WoS-CC) with publications between 1945 and 2022. Data regarding authorship, title, journal, year of publication, citation count, country, keywords, study design, and research hotspots were extracted and all elected articles were analyzed. Our results showed that among the articles selected, literature review and in vivo studies were the most common study designs. The USA and England were found as the countries with most publications. Alzheimer's disease (AD), aluminum, and neurotoxicity were found as the most frequent keywords. The articles most cited in world literature suggested that aluminum exposure is associated with Alzheimer's disease, Parkinson's disease (PD), dialysis encephalopathy, amyotrophic lateral sclerosis, neurodegeneration changes, cognitive impairment, such as bone damage, oxidative alterations, and cytotoxicity.
    Keywords:  Aluminum; Bibliographic databases; Bibliometric; Citation analysis; Neurodegenerative diseases; Toxicology
    DOI:  https://doi.org/10.1007/s12011-022-03427-9
  32. Mult Scler Relat Disord. 2022 Sep 17. pii: S2211-0348(22)00690-3. [Epub ahead of print]68 104185
    What are the trends in the treatment of multiple sclerosis in recent studies? - A bibliometric analysis with global productivity during 1980-2021.
    Serdar Aykaç, Sinan Eliaçık.
       BACKGROUND: There is no bibliometric analysis in the literature on the subject of the treatment of multiple sclerosis (MS), which is a disease with increasing prevalence, severely affecting the life and quality of life of patients. The purpose of this study was to analyze the scientific articles published on the subject of MS treatment, using bibliometric approaches and statistical methods, and thereby show the trend subjects and global productivity.
    METHODS: From 14,443 publications on the subject of MS between 1980 and 2021, 5010 in the category of article were retrieved from the Web of Science and analyzed statistically. Bibliometric network visualization diagrams were created to determine trend subjects, collaborations between countries and citation analyzes. Exponential Smoothing estimation was used to predict the number of articles to be published in the next 5 years. Correlations were determined using Spearman's correlation analysis.
    RESULTS: The 3 countries contributing the most to literature were found to be the USA (1385, 37.6%), Italy (700, 13.9%), and Germany (694, 13.8%). The most productive author was Hartung Hans-Peter (n = 82) and the most productive institution was the University of London (n = 198). The three most productive journals were the Multiple Sclerosis Journal (n = 354), Multiple Sclerosis and Related Disorders (n = 224), and Neurology (n = 204). The most studied subjects can be listed from past to present as interferon beta, disease-modifying treatment or drugs, relapsing, natalizumab, fingolimod, glatiramer acetate, fatigue, alemtuzumab, cytokines, mitoxantrone, MRI, adherence, depression, experimental autoimmune encephalomyelitis, quality of life, and biomarkers.
    CONCLUSION: The scientific production related to MS treatment shows growth chronologically over the years. According to the findings of the analysis done to identify trending subjects, the key words studied in recent years were determined to be fingolimod, alemtuzumab, disease-modifying therapy, ocrelizumab, teriflunomide, rituximab, dimethyl fumarate, safety, biomarkers, COVID-19, oxidative stress, inflammation, vitamin D, relapsing multiple sclerosis, cost-effectiveness, cladribine tablets, and medication adherence. Western countries, especially European countries, the USA, and Canada lead the way in research and scientific collaboration on the subject of MS treatment. These findings can contribute to a better understanding of this subject and can help provide new ideas for further studies.
    Keywords:  Bibliometric analysis; MS; Multiple sclerosis; Therapy; Treatment
    DOI:  https://doi.org/10.1016/j.msard.2022.104185
  33. Int J Gen Med. 2022 ;15 7523-7534
    Study on Chronic Obstructive Pulmonary Disease and Lung Cancer: Web of Science-Based Bibliometric and Visual Analysis.
    LiHong Xu, Peng Wang, YaNi Zhang, MuQi Wang, YaPing Li, WenHui Dang.
       Purpose: Chronic obstructive pulmonary disease (COPD) is one of the main risk factors for lung carcinomas. This study aimed to analyze and construct a model to assess scientific publications on the relationship between COPD and lung carcinomas.
    Patients and Methods: A literature search of the Web of Science database was performed for publications until November 2, 2021. Microsoft Excel and CiteSpace software were used to perform bibliometric and visual analysis of source journals, countries/regions, institutions, authors, research areas, and hot topics of selected publications.
    Results: A total of 2175 publications on the relationship between COPD and lung carcinomas were identified. The annual number of papers published and the total annual citation frequency in the field of COPD and lung carcinoma show an upward trend, and the current research hot topics are health, disease risk factors, disease burden, prevention and serious complications. The top three countries/regions with the number of published articles are the United States, China, and the United Kingdom. The author with the most signatures was Castaldi PJ of USA, followed by Xian JF of China. The lack of multinational/regional multi-center research illustrated that the distribution of research forces is unbalanced.
    Conclusion: According to this study, researchers can identify hot topics and explore new research directions in research of the relationship between COPD and lung carcinomas.
    Keywords:  bibliometrics; chronic obstructive pulmonary disease; lung carcinoma; lung neoplasms; visualization analysis
    DOI:  https://doi.org/10.2147/IJGM.S370781
  34. World J Orthop. 2022 Sep 18. 13(9): 853-869
    Evolution of evidence in spinal surgery - past, present and future Scientometric analysis of randomized controlled trials in spinal surgery.
    Sathish Muthu, Madhan Jeyaraman, Naveen Jeyaraman.
       BACKGROUND: Spine surgery is evolving and in the due course of its evolution, it is useful to have a comprehensive summary of the process to have a greater understanding to refine our future directives. With the multiple domains of research in the spine, it has become difficult for a surgeon to find the potential hotspots in research or identify the emerging research frontiers.
    AIM: To analyze RCTs (1990-2019) for potential research domains along with their research networks and identify the hot topics for future research.
    METHODS: A comprehensive and systematic analysis of all the RCTs published on spinal surgery from 1990 to 2019 retrieved from the Web of Science Core Collection database. Scientometric and visual analysis of their characteristics, cooperation networks, keywords, and citations were made using CiteSpace software. Journal and article impact index were retrieved from Reference Citation Analysis (RCA) Database.
    RESULTS: A total of 696 RCTs were published on spinal surgery from 1990 to 2019; of which, the United States (n = 263) and China (n = 71) made a significant contribution. Thomas Jefferson University (n = 16) was the leading contributor to RCTs on spinal surgery. Weinstein JN was the most cited author in the field followed by Deyo RA. Spine (n = 559) remained the top-cited journal for RCTs on spinal surgery. On literature co-citation analysis, spinal stenosis, anterior cervical discectomy and fusion, degenerative disc disease, and minimally invasive decompression were identified as the hotspots and potential research frontiers.
    CONCLUSION: The identified hotspots that extending the frontiers in the management of degenerative disorders of the spine through further research holds the potential for advancement in spinal care.
    Keywords:  Randomized controlled trials; Scientometrics; Spine surgery
    DOI:  https://doi.org/10.5312/wjo.v13.i9.853
  35. Medicine (Baltimore). 2022 Sep 23. 101(38): e30682
    Using the Sankey diagram to visualize article features on the topics of whole-exome sequencing (WES) and whole-genome sequencing (WGS) since 2012: Bibliometric analysis.
    Meng-Ju Li, Tsair-Wei Chien, Kuang-Wen Liao, Feng-Jie Lai.
       BACKGROUND: Sequencing technologies, such as whole-exome sequencing (WES) and whole-genome sequencing (WGS), have been increasingly applied to medical research in recent years. Which countries, journals, and institutes (called entities) contributed most to the fields (WES/WGS) remains unknown. Temporal bar graphs (TBGs) are frequently used in trend analysis of publications. However, how to draw the TBG on the Sankey diagram is not well understood in bibliometrics. We thus aimed to investigate the evolution of article entities in the WES/WGS fields using publication-based TBGs and compare the individual research achievements (IRAs) among entities.
    METHODS: A total of 3599 abstracts downloaded from icite analysis were matched to entities, including article identity numbers, citations, publication years, journals, affiliated countries/regions of origin, and medical subject headings (MeSH terms) in PubMed on March 12, 2022. The relative citation ratio (RCR) was extracted from icite analysis to compute the hT index (denoting the IRA, taking both publications and citations into account) for each entity in the years between 2012 and 2021. Three types of visualizations were applied to display the trends of publications (e.g., choropleth maps and the enhanced TBGs) and IRAs (e.g., the flowchart on the Sankey diagram) for article entities in WES/WGS.
    RESULTS: We observed that the 3 countries (the US, China, and the UK) occupied most articles in the WES/WGS fields since 2012, the 3 entities (i.e., top 5 journals, research institutes, and MeSH terms) were demonstrated on the enhanced TBGs, the top 2 MeSH terms were genetics and methods in WES and WGS, and the IRAs of 6 article entities with their hT-indices were succinctly and simultaneously displayed on a single Sankey diagram that was never launched in bibliographical studies.
    CONCLUSION: The number of WES/WGS-related articles has dramatically increased since 2017. TBGs, particularly with hTs on the Sankey, are recommended for research on a topic (or in a discipline) to compare trends of publications and IRAs for entities in future bibliographical studies.
    DOI:  https://doi.org/10.1097/MD.0000000000030682
  36. Head Neck. 2022 Oct 04.
    One hundred most-cited articles in head and neck surgery and analysis of female authorship.
    Monica S Trent, Lauren Michelle, Kelsey Roman, Joshua K Kim, Yarah M Haidar, Tjoson Tjoa, Mehdi Abouzari.
       BACKGROUND: While female head and neck surgeons have made significant contributions to the field, women's achievements in scientific communication have traditionally been underreported.
    METHODS: A search of high-impact journals in the field of head and neck surgery was performed in the Elsevier's Scopus database to identify the top 100 most-cited articles.
    RESULTS: The top 100 most-cited articles (during the span of 1953 and 2016) had the highest total number of citations between 2005 and 2009. Women accounted for 36% of first authors and 25% of corresponding authors. Change in the relative number of first female authors in these top 100 articles did not increase significantly between 1950 and 2019.
    CONCLUSION: The proportion of female first authors in head and neck surgery has not significantly increased over the past several decades, despite greater numbers of female trainees. Our findings support the need for additional research on female representation in head and neck surgery.
    Keywords:  female authorship; head and neck surgery; impact; otolaryngology; top cited
    DOI:  https://doi.org/10.1002/hed.27210
  37. Front Psychiatry. 2022 ;13 940741
    Thematic trends and knowledge structure on cognitive behavior therapy for insomnia: A bibliometric and visualization analysis.
    Qianqian Xin, Dhirendra Paudel, Kai An, Youran Ye, Shuqiong Zheng, Lei Chen, Bin Zhang, Honglei Yin.
       Objective: To find publications trend about cognitive behavior therapy for insomnia (CBTI) using bibliometric and visualization analysis. In this study, the authors sought to identify the publication trends of peer-reviewed articles about CBTI.
    Materials and methods: Analyses were focused on the past 18 years from 2004 to 2021. All searches were performed on the Web of Science Core Collection database. The search was repeated to include structural cognitive behavior therapy for insomnia. Quantitative analysis was assessed using the bibliometric tool. Visualization analysis was carried out using VOSviewer.
    Results: In the 736 articles reviewed, the number of publications has been increasing every year for the past 18 years. Behavioral sleep medicine and sleep were the most active journals published on CBTI. The United States and Canada had the highest scientific publications in the field. Morin CM and Espie CA were the most active authors. The study type mostly observed were randomized controlled trials, meta-analyses, and epidemiological. Publications on digital-based cognitive behavior therapy and accessibility to primary care settings represent the future trends of research on CBTI.
    Conclusion: Possible explanations for CBTI publication trends were discussed, including the emergence of the evidence-based therapy, feasibility, and scalability. Potential CBTI publications trends in the future and clinical implications were also discussed.
    Keywords:  bibliometric; cognitive behavior therapy; insomnia; psychotherapy; visualization
    DOI:  https://doi.org/10.3389/fpsyt.2022.940741
  38. World J Diabetes. 2022 Sep 15. 13(9): 786-798
    Mapping the global research landscape on insulin resistance: Visualization and bibliometric analysis.
    Sa'ed H Zyoud, Muna Shakhshir, Amer Koni, Amani S Abushanab, Moyad Shahwan, Ammar Abdulrahman Jairoun, Rand Al Subu, Adham Abu Taha, Samah W Al-Jabi.
       BACKGROUND: Insulin resistance is a risk factor for metabolic syndromes and is associated with a wide variety of metabolic illnesses, including obesity, type 2 diabetes, and cardiovascular disease.
    AIM: To investigate and map global insulin resistance studies.
    METHODS: A bibliometric methodology was applied to the literature retrieved from the Scopus database and Reference Citation Analysis (https://www.referencecitationanalysis.com) by using a validated search strategy. The study period was limited from 2002 to 2021. Bibliometric indicators and mapping were presented.
    RESULTS: A total of 26808 articles on the topic of insulin resistance were included in the Scopus database. The articles included research articles (n = 21918; 81.76%), review articles (n = 2641; 9.85%), and letters (n = 653; 2.44%). During the study period, 136 countries contributed to the research on insulin resistance. The highest number of articles was from the United States (n = 7360; 27.45%), followed by China (n = 3713; 13.85%), Japan (n = 1730, 6.45%), Italy (n = 1545; 5.54%), and the United Kingdom (n = 1484; 5.54%). The retrieved articles identified two main research themes: "inflammatory mechanisms in the regulation of insulin resistance" and "mechanisms linking obesity to insulin resistance".
    CONCLUSION: Our data show that insulin resistance has steadily gained interest from researchers, as evidenced by the number of citations and yearly publications. Publications have grown significantly in the last decade, while low-income countries with greater burdens continue to produce fewer publications in this field. This approach might assist researchers in choosing new research areas and recognizing research hotspots and frontiers. In the future, perhaps high-quality clinical evidence will be acquired.
    Keywords:  Bibliometric; Insulin resistance; Research hotspots; Scopus; VOSviewer
    DOI:  https://doi.org/10.4239/wjd.v13.i9.786
  39. Front Public Health. 2022 ;10 967829
    Scars of COVID-19: A bibliometric analysis of post-COVID-19 fibrosis.
    Han Zhong, Yang Zhou, Shu-Ya Mei, Ri Tang, Jin-Hua Feng, Zheng-Yu He, Qiao-Yi Xu, Shun-Peng Xing.
       Background: The coronavirus disease 2019 (COVID-19) becomes a worldwide public health threat. Increasing evidence proves that COVID-19-induced acute injuries could be reversed by a couple of therapies. After that, post-COVID-19 fibrosis (PCF), a sequela of "Long COVID," earns rapidly emerging concerns. PCF is associated with deteriorative lung function and worse quality of life. But the process of PCF remains speculative. Therefore, we aim to conduct a bibliometric analysis to explore the overall structure, hotspots, and trend topics of PCF.
    Materials and methods: A comprehensive search was performed in the Web of Science core database to collect literature on PCF. Search syntax included COVID-19 relevant terms: "COVID 19," "COVID-19 Virus Disease," "COVID-19 Virus Infection," "Coronavirus Disease-19," "2019 Novel Coronavirus Disease," "2019 Novel Coronavirus Infection," "SARS Coronavirus 2 Infection," "COVID-19 Pandemic," "Coronavirus," "2019-nCoV," and "SARS-CoV-2"; and fibrosis relevant terms: "Fibrosis," "Fibroses," and "Cirrhosis." Articles in English were included. Totally 1,088 publications were enrolled. Searching results were subsequentially exported and collected for the bibliometric analysis. National, organizational, and individual level data were analyzed and visualized through biblioshiny package in the R, VOSviewer software, the CiteSpace software, and the Graphical Clustering Toolkit (gCLUTO) software, respectively.
    Results: The intrinsic structure and development in the field of PCF were investigated in the present bibliometric analysis. The topmost keywords were "COVID-19" (occurrences, 636) surrounded by "SARS-CoV-2" (occurrences, 242), "coronavirus" (occurrences, 123), "fibrosis" (occurrences, 120), and "pneumonia" (occurrences, 94). The epidemiology, physiopathology, diagnosis, and therapy of PCF were extensively studied. After this, based on dynamic analysis of keywords, hot topics sharply changed from "Wuhan," "inflammation," and "cytokine storm" to "quality of life" and "infection" through burst detection; from "acute respiratory syndrome," "cystic-fibrosis" and "fibrosis" to "infection," "COVID-19," "quality-of-life" through thematic evolution; from "enzyme" to "post COVID." Similarly, co-cited references analysis showed that topics of references with most citations shift from "pulmonary pathology" (cluster 0) to "COVID-19 vaccination" (cluster 6). Additionally, the overview of contributors, impact, and collaboration was revealed. Summarily, the USA stood out as the most prolific, influential, and collaborative country. The Udice French Research University, Imperial College London, Harvard University, and the University of Washington represented the largest volume of publications, citations, H-index, and co-authorships, respectively. Dana Albon was the most productive and cited author with the strongest co-authorship link strength. Journal of Cystic Fibrosis topped the list of prolific and influential journals.
    Conclusion: Outcomes gained from this study assisted professionals in better realizing PCF and would guide future practices. Epidemiology, pathogenesis, and therapeutics were study hotspots in the early phase of PCF research. As the spread of the COVID-19 pandemic and progress in this field, recent attention shifted to the quality of life of patients and post-COVID comorbidities. Nevertheless, COVID-19 relevant infection and vaccination were speculated to be research trends with current and future interest. International cooperation as well as in-depth laboratory experiments were encouraged to promote further explorations in the field of PCF.
    Keywords:  COVID-19; etiology; fibrosis; hotspots and trends; therapy
    DOI:  https://doi.org/10.3389/fpubh.2022.967829
  40. J Mol Neurosci. 2022 Oct 06.
    Cerebral Small Vessel Disease: A Bibliometric Analysis.
    Wei Ma, Yi-Bao Yang, Ting-Ting Xie, Yi Xu, Na Liu, Xue-Ni Mo.
      Cerebral small vessel disease is a common neurological disease, and its incidence is increasing year by year worldwide. In recent years, research on cerebral small vessel disease has gained more and more attention. Our research aims to visualize publications to identify the hotspots and frontiers of cerebral small vessel disease research, and to provide reference and guidance for further research. Publications related to cerebral small vessel disease were searched from the Web of Science Core Collection and screened according to inclusion criteria. CiteSpace 5.8.R3 was used to evaluate and visualize results, including generating web maps and analyzing annual publications, countries, institutions, bibliographic and co-cited references, and keywords; in this article, we use CiteSpace and VOSviewer for the 2012 Cerebral small vessel disease and bibliometric analysis from January 1, 2022 to April 30, 2022. A total of 3037 papers related to cerebral small vessel disease were retrieved, and the number of published papers showed a steady upward trend. Among them, Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration, the most symbolic references in the field of cerebral small vessel disease have been cited a total of 438 times. Stroke is the most active journal (227 articles) and USA publishes up to 800 articles. Harvard Med SchUniv Edinburgh (133 papers) and Charidimou (85 papers) are the institutions and authors who have made the most contributions in this field, respectively. Among the keywords, most of them are related to the pathogenesis of cerebral small vessel disease. After 2018, gut-brain axis and cortex are the keywords with the strongest number of cited outbreaks. There is increasing evidence that cerebral small vessel disease is a research frontier and may remain a research hotspot in the future.
    Keywords:  Bibliometrics; Cerebral small vessel disease; CiteSpace
    DOI:  https://doi.org/10.1007/s12031-022-02070-2
  41. Front Pharmacol. 2022 ;13 951004
    Research trends in ulcerative colitis: A bibliometric and visualized study from 2011 to 2021.
    Tai Zhang, Beihua Zhang, Wende Tian, Fengyun Wang, Jiaqi Zhang, Xiangxue Ma, Yuchen Wei, Xudong Tang.
      Background: Ulcerative colitis (UC) is an idiopathic inflammatory bowel disease with repeated relapses and remissions. Despite decades of effort, numerous aspects, including the initiating event and pathogenesis of UC, still remain ambiguous, which requires ongoing investigation. Given the mass of publications on UC, there are multidimensional challenges to evaluating the scientific impact of relevant work and identifying the current foci of the multifaceted disease. Accordingly, herein, we aim to assess the global growth of UC research production, analyze patterns of research areas, and evaluate trends in this area. Methods: The Web of Science Core Collection of Clarivate Analytics was searched for articles related to UC published from 2011 to 2021. Microsoft Office Excel 2019 was used to visualize the number of publications over time. Knowledge maps were generated using CiteSpace and VOSviewer to analyze collaborations among countries, institutions, and authors and to present the journey of UC research as well as to reveal the current foci of UC research. Results: A total of 5,088 publications were evaluated in the present study. China had the most publications (1,099, 22.5%). Univ Calif San Diego was the most productive institution (126, 2.48%). William J Sandborn published the greatest number of articles (100, 1.97%). Toshifumi Hibi was the most influential author in the field with a betweenness centrality of 0.53. Inflammatory bowel diseases was identified as the most prolific journal (379, 7.45%). Gastroenterology was the most co-cited journal (3,730, 4.02%). "Vedolizumab," "tofacitinib," "Faecalibacterium prausnitzii," "fecal microbiota transplantation (FMT)," "toll-like receptor 4," and "nucleotide-binding oligomerization domain-like receptor protein 3 inflammasome" were considered the hot topics. Conclusion: In UC research, manuscripts that had high impacts on the scientific community provided an evidence base. UC therapy has entered the era of personalized and precision therapy. As research on FMT, anti-integrin antibodies, Janus kinase inhibitors, and anti-tumor necrosis factor drugs continues to grow, their use in the clinical setting may also expand.
    Keywords:  bibliometrics; mechanisms; therapy; trends; ulcerative colitis
    DOI:  https://doi.org/10.3389/fphar.2022.951004
  42. Front Pharmacol. 2022 ;13 995512
    Bibliometric and visualized analysis of the application of nanotechnology in glioma.
    Xue Du, Chunbao Chen, Lu Yang, Yu Cui, Bangxian Tan.
      Background: Glioma is the most prevalent malignant tumor in the central nervous system (CNS). Due to its highly invasive characteristics and the existence of the blood-brain barrier (BBB), the early diagnosis and treatment of glioma remains a major challenge in cancer. With the flourishing development of nanotechnology, targeted nano-therapy for glioma has become a hot topic of current research by using the characteristics of nanoparticles (NPs), such as it is easier to pass the blood-brain barrier, degradable, and aids controllable release of drugs in the brain. The purpose of this study is to visualize the scientific achievements and research trends of the application of nanotechnology in glioma. Methods: We searched the literature related to glioma nanotechnology on the Web of Science (WOS). The bibliometric and visual analysis was performed mainly using CiteSpace, VOSviewer, and R software, for countries/regions, authors, journals, references, and keywords associated with the field. Results: A total of 3,290 publications from 2012 to June 2022 were searched, and 2,041 works of literature were finally obtained according to the search criteria, the number of publications increasing year by year, with an average growth rate (AGR) of 15.22% from 2012 to 2021. China published 694 (20.99%), followed by the United States (480, 20.70%). The institution with the highest number of publications is Fudan Univ (111, 13.16%), and 80% of the top ten institutions belong to China. HUILE GAO (30) and XINGUO JIANG (30) both published the largest number of research studies. STUPP R (412) was the most cited author, followed by GAO HL (224). The degree of collaboration (DC) among countries/regions, research institutions, and authors is 23.37%, 86.23%, and 99.22%, respectively. International Journal of Nanomedicine published the largest number of publications (81), followed by Biomaterials (73). Biomaterials (1,420) was the most cited journal, followed by J Control Release (1,300). The high frequency of keywords was drug delivery (487), followed by nanoparticle (450), which indicates that nanoparticles (NPs) as a carrier for drug delivery is a hot topic of current research and a direction of continuous development. Conclusion: In recent years, nanotechnology has attracted much attention in the medical field. Cooperation and communication between countries/regions and institutions need to be strengthened in future research to promote the development of nanomedicine. Nanotherapeutic drug delivery systems (NDDS) can enhance drug penetration and retention in tumor tissues, improve drug targeting, and reduce the toxic side effects of drugs, which has great potential for the treatment of glioma and has become the focus of current research and future research trends in the treatment of glioma.
    Keywords:  bibliometric; blood–brain barrier; drug delivery; glioma; nanoparticles; nanotechnology
    DOI:  https://doi.org/10.3389/fphar.2022.995512
  43. Quant Sci Stud. 2022 Feb;2(4): 1144-1169
    Continued use of retracted papers: Temporal trends in citations and (lack of) awareness of retractions shown in citation contexts in biomedicine.
    Tzu-Kun Hsiao, Jodi Schneider.
      We present the first database-wide study on the citation contexts of retracted papers, which covers 7,813 retracted papers indexed in PubMed, 169,434 citations collected from iCite, and 48,134 citation contexts identified from the XML version of the PubMed Central Open Access Subset. Compared with previous citation studies that focused on comparing citation counts using two time frames (i.e., preretraction and postretraction), our analyses show the longitudinal trends of citations to retracted papers in the past 60 years (1960-2020). Our temporal analyses show that retracted papers continued to be cited, but that old retracted papers stopped being cited as time progressed. Analysis of the text progression of pre- and postretraction citation contexts shows that retraction did not change the way the retracted papers were cited. Furthermore, among the 13,252 postretraction citation contexts, only 722 (5.4%) citation contexts acknowledged the retraction. In these 722 citation contexts, the retracted papers were most commonly cited as related work or as an example of problematic science. Our findings deepen the understanding of why retraction does not stop citation and demonstrate that the vast majority of postretraction citations in biomedicine do not document the retraction.
    Keywords:  citation analysis; citation context analysis; intentional postretraction citation; postretraction citation PubMed Central Open Access Subset; retraction
    DOI:  https://doi.org/10.1162/qss_a_00155
  44. Front Public Health. 2022 ;10 901112
    Comprehensive metrological and content analysis of the income inequality research in health field: A bibliometric analysis.
    Guocheng Xiang, Jingjing Liu, Shihu Zhong, Mingjun Deng.
      The association between income inequality in a society and the poor health status of its people has attracted the attention of researchers from multiple disciplines. Based on the ISI Web of Science database, bibliometric methods were used to analyze 546 articles related to income inequality research in health field published between 1997 and 2021. We found that the USA contributed most articles, the Harvard Univ was the most influential institution, Social Science & Medicine was the most influential journal, and Kawachi I was the most influential author; the main hotspots included the income inequality, income, health inequality, mortality, socioeconomic factors, concentration index, social capital, self-rated health, income distribution, infant mortality, and population health in 1997-2021; the cardiovascular disease risk factor, social capital income inequality, individual mortality risk, income-related inequalities, understanding income inequalities, income inequality household income, and state income inequality had been the hot research topics in 1997-2003; the self-assessed health, achieving equity, income-related inequalities, oral health, mental health, European panel, occupational class, and cardiovascular diseases had been the hot research topics in 2004-2011; the adolescent emotional problem, South Africa, avoidable mortality, rising inequalities, results from world health survey, working-age adult, spatial aggregation change, prospective study, and mental health-empirical evidence had been the hot research topics in 2012-2021; there were 11 articles with strong transformation potential during 2012-2021. The research results of this paper are helpful to the scientific understanding of the current status of income inequality research in health field.
    Keywords:  CiteSpace; bibliometric analysis; health; income inequality; knowledge mapping
    DOI:  https://doi.org/10.3389/fpubh.2022.901112
  45. SN Appl Sci. 2022 ;4(10): 281
    Research on metallic glasses at the atomic scale: a systematic review.
    Nicolás Amigo, Pablo Cortés, Felipe J Valencia.
      Metallic glasses (MGs) have been long investigated in material science to understand the origin of their remarkable properties. With the help of computational simulations, researchers have delved into structure-property relationships, leading to a large number of reports. To quantify the available literature, we employed systematic review and bibliometric analysis on studies related to MGs and classical molecular dynamics simulations from 2000 to 2021. It was found that the total number of articles has increased remarkably, with China and the USA producing more than half of the reports. However, high-impact articles were mainly conducted in the latter. Collaboration networks revealed that top contributor authors are strongly connected with other researchers, which emphasizes the relevance of scientific cooperation. In regard to the evolution of research topics, according to article keywords, plastic behavior has been a recurrent subject since the early 2000s. Nevertheless, the traditional approach of studying monolithic MGs at the short-range order evolved to complex composites with characterizations at the medium-range order, including topics such as nanoglasses, amorphous/crystalline nanolaminates, rejuvenation, among others. As a whole, these findings provide researchers with an overview of past and current trends of research areas, as well as some of the leading authors, productivity statistics, and collaboration networks.
    Keywords:  Bibliometric analysis; Metallic glasses; Molecular dynamics; Systematic review
    DOI:  https://doi.org/10.1007/s42452-022-05170-1
  46. Front Med (Lausanne). 2022 ;9 960316
    Bibliometric-analysis visualization and review of non-invasive methods for monitoring and managing the portal hypertension.
    XiaoHan Sun, Hong Bo Ni, Jian Xue, Shuai Wang, Afaf Aljbri, Liuchun Wang, Tian Hang Ren, Xiao Li, Meng Niu.
       Background: Portal hypertension monitoring is important throughout the natural course of cirrhosis. Hepatic venous pressure gradient (HVPG), regarded as the golden standard, is limited by invasiveness and technical difficulties. Portal hypertension is increasingly being assessed non-invasively, and hematological indices, imaging data, and statistical or computational models are studied to surrogate HVPG. This paper discusses the existing non-invasive methods based on measurement principles and reviews the methodological developments in the last 20 years.
    Methods: First, we used VOSviewer to learn the architecture of this field. The publications about the non-invasive assessment of portal hypertension were retrieved from the Web of Science Core Collection (WoSCC). VOSviewer 1.6.17.0 was used to analyze and visualize these publications, including the annual trend, the study hotspots, the significant articles, authors, journals, and organizations in this field. Next, according to the cluster analysis result of the keywords, we further retrieved and classified the related studies to discuss.
    Results: A total of 1,088 articles or review articles about our topic were retrieved from WoSCC. From 2000 to 2022, the number of publications is generally growing. "World Journal of Gastroenterology" published the most articles (n = 43), while "Journal of Hepatology" had the highest citations. "Liver fibrosis" published in 2005 was the most influential manuscript. Among the 20,558 cited references of 1,088 retrieved manuscripts, the most cited was a study on liver stiffness measurement from 2007. The highest-yielding country was the United States, followed by China and Italy. "Berzigotti, Annalisa" was the most prolific author and had the most cooperation partners. Four study directions emerged from the keyword clustering: (1) the evaluation based on fibrosis; (2) the evaluation based on hemodynamic factors; (3) the evaluation through elastography; and (4) the evaluation of variceal bleeding.
    Conclusion: The non-invasive assessment of portal hypertension is mainly based on two principles: fibrosis and hemodynamics. Liver fibrosis is the major initiator of cirrhotic PH, while hemodynamic factors reflect secondary alteration of splanchnic blood flow. Blood tests, US (including DUS and CEUS), CT, and magnetic resonance imaging (MRI) support the non-invasive assessment of PH by providing both hemodynamic and fibrotic information. Elastography, mainly USE, is the most important method of PH monitoring.
    Keywords:  VOSviewer; bibliometric; elastography; non-invasive; portal hypertention
    DOI:  https://doi.org/10.3389/fmed.2022.960316
  47. Front Public Health. 2022 ;10 912151
    Current status and trends in researches based on public intensive care databases: A scientometric investigation.
    Min Li, Shuzhang Du.
       Objective: Public intensive care databases cover a wide range of data that are produced in intensive care units (ICUs). Public intensive care databases draw great attention from researchers since they were time-saving and money-saving in obtaining data. This study aimed to explore the current status and trends of publications based on public intensive care databases.
    Methods: Articles and reviews based on public intensive care databases, published from 2001 to 2021, were retrieved from the Web of Science Core Collection (WoSCC) for investigation. Scientometric software (CiteSpace and VOSviewer) were used to generate network maps and reveal hot spots of studies based on public intensive care databases.
    Results: A total of 456 studies were collected. Zhang Zhongheng from Zhejiang University (China) and Leo Anthony Celi from Massachusetts Institute of Technology (MIT, USA) occupied important positions in studies based on public intensive care databases. Closer cooperation was observed between institutions in the same country. Six Research Topics were concluded through keyword analysis. Result of citation burst indicated that this field was in the stage of rapid development, with more diseases and clinical problems being investigated. Machine learning is still the hot research method in this field.
    Conclusions: This is the first time that scientometrics has been used in the investigation of studies based on public intensive databases. Although more and more studies based on public intensive care databases were published, public intensive care databases may not be fully explored. Moreover, it could also help researchers directly perceive the current status and trends in this field. Public intensive care databases could be fully explored with more researchers' knowledge of this field.
    Keywords:  intensive care; public database; research; scientometric investigation; status
    DOI:  https://doi.org/10.3389/fpubh.2022.912151
  48. Front Neurol. 2022 ;13 936744
    A bibliometric of research trends in acupuncture for spinal cord injury: Quantitative and qualitative analyses.
    Yi Huang, Kelin He, Dandan Fang, Fengjia Ni, Bei Qiu, Kang Liang, Ruijie Ma.
       Introduction: Spinal cord injury (SCI) is a severe disease of the central nervous system with a very high disability rate that seriously affects the daily life of patients. Acupuncture is one of the rehabilitation therapies that has shown significant efficacy in treating post-SCI complications such as motor disorders, neuropathic pain, and neurogenic bladder. Current studies have focused on the effectiveness and mechanisms of acupuncture for SCI, but no studies are available to analyze the bibliometrics of publications related to this area.
    Methods: Publications related to acupuncture for SCI were retrieved from the Web of Science Core Collection for quantitative and qualitative analyses. The quantitative analysis was unfolded in the following six main areas: annual publications, countries, institutions, authors, sources, and keywords. The qualitative analysis section screened out publications with high annual citation rates and categorized them according to the study content.
    Results: There were 213 relevant publications, more than half of which were journal articles. The number of publications showed a fluctuating upward trend. China and the United States were hub countries for related publications and had extensive cooperation with other countries. The most relevant author was Yuanshan Zeng from Sun Yat-sen University, China. The efficacy and mechanism of acupuncture for neuropathic pain after SCI was the first research hotspot in this field, and electroacupuncture was the most widely used technique. In the past 5 years, the mechanism of acupuncture to improve the local microenvironment of SCI and promote nerve regeneration had become a new research trend. At the same time, acupuncture had been gradually applied to various complications after SCI and in veterinary medicine.
    Conclusion: The findings suggest that research on acupuncture for SCI is still flourishing, and more research on electroacupuncture for promoting nerve repair and regeneration after SCI will be available in the future.
    Keywords:  acupuncture; bibliometrics; qualitative analysis; quantitative analysis; spinal cord injury
    DOI:  https://doi.org/10.3389/fneur.2022.936744
  49. Front Pharmacol. 2022 ;13 929223
    A bibliometric research based on hotspots and frontier trends of denosumab.
    Bolin Ren, Xiaolei Ren, Lu Wang, Chao Tu, Wenchao Zhang, Zhongyue Liu, Lin Qi, Lu Wan, Ke Pang, Cheng Tao, Zhihong Li.
      Denosumab is a monoclonal antibody that targets and inhibits the osteoclast activating factor receptor activator for nuclear factor-κB ligand (RANKL). It has been widely used in the treatment of osteoporosis, giant cell tumors of bone, and in the prevention of malignant skeletal-related events (SREs). We collected the research results and related MeSH terms of denosumab from 2011 to 2021 through the Web of Science and PubMed, respectively. The literature was visualized and analyzed by CiteSpace and bibliometric online analysis platforms. The MeSH terms were biclustered using the Bibliographic Co-Occurrence Analysis System (BICOMB) and graph clustering toolkit (gCLUTO). The results show that the number of denosumab-related annual publications had increased from 51 to 215, with the United States leading and Amgen Inc. being the most influential in the past 10 years. Articles published in the Journal of Bone and Mineral Research had the highest total citations. Three scholars from Shinshu University in Matsumoto, Yukio Nakamura, Takako Suzuki, and Hiroyuki Kato, joined the field relatively late but produced the most. The clinical comparison and combination of denosumab with other drugs in the treatment of osteoporosis was the most significant focus of research. Drug withdrawal rebound and management strategies have gained more attention and controversy recently. MeSH analysis revealed eight major categories of research hotspots. Among them, exploring the multiple roles of the RANK-RANKL-OPG system in tumor progression, metastasis, and other diseases is the potential direction of future mechanism research. It is a valuable surgical topic to optimize the perioperative drug administration strategy for internal spinal fixation and orthopedic prosthesis implantation. Taken together, the advantages of denosumab were broad and cost-effective. However, there were still problems such as osteonecrosis of the jaw, severe hypocalcemia, a high recurrence rate of giant cells in the treatment of bone and individual sarcoidosis, and atypical femoral fractures, which need to be adequately solved.
    Keywords:  RANKL; bibliometric and network analysis; biclustering analysis; denosumab; osteoporosis
    DOI:  https://doi.org/10.3389/fphar.2022.929223
  50. Ir J Med Sci. 2022 Oct 03.
    Impact factor JUMPS after the 2020 COVID-19 pandemic: a retrospective study in Dermatology journals.
    Leslie-Marisol González-Hermosillo, Ernesto Roldan-Valadez.
       BACKGROUND: The term "JUMPS" was used to describe the impact factor (IF) in an article published in PubMed in 2021, representing an increase of more than 40% of IF.
    AIMS: In this study, we aimed to compare the growth rate of IF JUMPS in Dermatology in the last 5 years, and particularly the effect of the 2020 COVID-19 pandemic.
    METHODS: This study evaluated the growth rate (JUMP) in IF from 2016 to 2020. We used the Friedman and Wilcoxon signed ranks tests. We classified JUMPS in negative growth rate; Q1 to Q4 quartiles; and journals with > 100%. A 76-100% growth rate was observed in five (7%) journals, and twelve journals (17%) depicted a 51-75% percentage of change.
    RESULTS: Several journals in the Dermatology category increased their IF by 50%. Repeated measures analyses showed a significant difference (p < .001).
    CONCLUSION: Although we found journals with growth rates in the four quartiles, no journals depicted negative growth rates nor > 100% growth. Knowing the growing trends in this category might supplement the assessment of target journals for authors looking to submit their works.
    Keywords:  Algorithms; Bibliometrics; Citation; Dermatology; Journal impact factor; Self-evaluation
    DOI:  https://doi.org/10.1007/s11845-022-03179-4
  51. Front Res Metr Anal. 2022 ;7 990921
    Impact of supervisors' research style on young biomedical scientists' capacity development as measured by REDi, a novel index of crossdisciplinarity.
    Akiko Hashiguchi, Hiroka Hamada, Satoru Takahashi, Keisuke Honda.
      The challenge for medical schools in Japan is to develop research activities for innovation. This study aimed at analyzing the connection between the research output of "promising researchers" (next-generation leaders in terms of research activity) and their supervisors' past research activities to identify those factors that impact researchers' performance. Activity was analyzed from the viewpoints of productivity, coauthorship networks, and research impact using a novel index called the Research Diversity Index (REDi) that quantifies crossdisciplinarity. Research funding, which has not yet been fully utilized in correlation studies of the characteristics of authors, was also considered in this study. For the promising researchers extracted using betweenness centrality scores within coauthorship networks, there were diachronic correlations between the records of the promising researchers and those of their supervisors. Supervisor leadership as measured by the number of last-authored publications and extent of networking had a positive effect on the promising researchers productivity. Supervisors' research style of integrating knowledge from multiple fields, as measured by REDi, was negatively correlated with the publication impact of promising researchers, suggesting that REDi is useful as a novel indicator of research quality not being captured by existing indices. It was also noted that establishing an academic presence through extensive collaborations could be advantageous for obtaining research funding, especially from top-down government programs. The possible implications of this study for promoting research activities are the importance of incorporating new doctorates into research groups at an early stage and that of promoting interinstitutional, crossdisciplinary collaborations.
    Classification code: MSC: 62P10 Applications of statistics to biology and medical sciences; meta-analysis.JEL: Z1Z10 Cultural Economics • Economic Sociology • Economic Anthropology- General.
    Keywords:  Research Diversity Index (REDi); collaborative networks; correlation analysis; diachronic effect; funding; research activities
    DOI:  https://doi.org/10.3389/frma.2022.990921
  52. Heliyon. 2022 Oct;8(10): e10704
    Exploring the frontiers of sustainable livelihoods research within grassland ecosystem: A scientometric analysis.
    Tong Li, Lizhen Cui, Wencong Lv, Xiufang Song, Xiaoyong Cui, Li Tang.
      Grassland degradation has become a global social-ecological problem, which seriously limits the sustainability of indigenous people's livelihoods. Bibliometrics, a type of analysis based on the Science Citation Index-Expanded (SCI-E), was therefore performed to explore the research trends and focus areas of studies on sustainable livelihoods (SLs). We conducted an in-depth analysis of 489 research publications and their 25,144 references from 1991 to 2020. The results show that only few papers have been published, but the number of countries and research institutions involved shows an overall imbalance. We identified eight main clusters based on keyword co-occurrence, these being studies the content of which is an important representation of current research directions in this topic. The document co-citation analysis revealed 10 research clusters, representing the frontiers of research. Clusters included the following topics: NPP (Net Primary Productivity) dynamics, global change, ecological restoration, risk indicators, livelihood strategies, smallholder systems, drought relief, sustainable land management and common pool resources. We reviewed and interpreted these clusters in depth with a view to provide an up-to-date account of the dynamics of this research. As the first scientometric evaluation of research on sustainable livelihoods in grassland ecosystems, this study provides several theoretical and practical implications for global poverty eradication research, which are of great scientific value for global sustainable development.
    Keywords:  Grassland degradation; Scientometric; Sustainability management; Sustainable livelihoods
    DOI:  https://doi.org/10.1016/j.heliyon.2022.e10704
  53. Found Sci. 2022 Sep 28. 1-28
    Mapping Manuel Sandoval Vallarta (1899-1977) Scientific Contribution.
    María de la Paz Ramos-Lara, Gustavo Carreón-Vázquez, Edgar Acatitla-Romero, Rosa María Mendoza-Rosas.
      This paper employs network theory, mining data and bibliometric analysis when mapping the scientific contribution of Nobel Prize candidate; Manuel Sandoval Vallarta, the first and most renowned Mexican physicist and important figure in Latin American science. Vallarta died in 1977, and the existing literature is about his life and contributions to science but not about how those are still valuable today. This paper is the first to highlight, with mapping tools, that his contributions are relevant to the international community of cosmic rays (as he was pioneer and leader), quantum mechanics and relativity. These tools delivered three findings: Identify how he built his own field of study, same as universal knowledge. Unveil that the backward and forward Vallarta citations follow a scale-free network distribution. Determine social factors that benefited or affected his scientific activities-such as World War II interrupting Vallarta's successful productivity at Massachusetts Institute of Technology. Furthermore, this study confirmed the interdisciplinary nature of the mapping studies of the scientist's contributions using scientometric tools. As a result, several interesting questions arose throughout our research, some of which were answered from the history and philosophy of science. However, others need to be analyzed by experts in the fields of Vallarta. Mapping research sends an invitation to interdisciplinary dialogue/research between experts in different areas of study to better understand the process of knowledge production both, individual and collective.
    Keywords:  Bibliometric analysis; Cosmic rays; Interdisciplinary research; Manuel Sandoval Vallarta (Mexico); Mapping scientific production; Network theory and tag-clouds; Quantum mechanics and relativity
    DOI:  https://doi.org/10.1007/s10699-022-09872-y
  54. Front Pharmacol. 2022 ;13 940791
    Bibliometric and visual analysis of nephrotoxicity research worldwide.
    Tianmu He, Jingwen Ao, Cancan Duan, Rong Yan, Xiaomei Li, Liu Liu, Jianyong Zhang, Xiaofei Li.
      Background: Nephrotoxicity of drugs contributes to acute kidney injury with high mortality and morbidity, which crucially limits the application and development of drugs. Although many publications on nephrotoxicity have been conducted globally, there needs to be a scientometric study to systematically analyze the intellectual landscape and frontiers research trends in the future. Methods: Publications on nephrotoxicity from 2011 to 2021 were collected to perform bibliometric visualization using VOSviewer, CiteSpace, and Scimago Graphica software based on the Web of Science Core Collection. Results: A total of 9,342 documents were analyzed, which were primarily published in the United States (1,861), China (1,724), and Egypt (701). For institutions, King Saud University (166) had the most publications; Food and Chemical Toxicology, PLOS One, and Antimicrobial Agents and Chemotherapy were productive journals, primarily concentrating on the mechanisms of nephrotoxicity and renoprotective in cisplatin and antibiotics, especially in oxidative stress. Burst detection suggested that cisplatin, piperacillin-tazobactam, vancomycin-induced nephrotoxicity, antioxidants, and new biomaterials are frontiers of research. Conclusion: This study first provides an updated perspective on nephrotoxicity and renoprotective strategies and mechanisms. This perspective may benefit researchers in choosing suitable journals and collaborators and assisting them in the deep understanding of the nephrotoxicity and renoprotective hotspots and frontiers.
    Keywords:  acute kidney injury; bibliometrics; hotspot; nephrotoxicity mechanism; renoprotective strategies
    DOI:  https://doi.org/10.3389/fphar.2022.940791
  55. Int Heart J. 2021 ;63(5): 1017
    Most Cited Articles in 2021.
      
    DOI:  https://doi.org/10.1536/ihj.63-5_Mostcited
  56. BMJ Health Care Inform. 2022 Oct;pii: e100594. [Epub ahead of print]29(1):
    Three-year trends in literature on artificial intelligence in ophthalmology and vision sciences: a protocol for bibliometric analysis.
    Hayley Monson, Jeff Demaine, Laura Banfield, Tina Felfeli.
       INTRODUCTION: The aim of this study is to provide an insight into the literature at the intersection of artificial intelligence and ophthalmology.
    METHODS AND ANALYSIS: The project will be performed in four key stages: formulation of search terms, literature collection, literature screening and literature analysis. A comprehensive search of databases including Scopus, Web of Science, Dimensions and Cochrane will be conducted. The Distiller SR software will be used for manual screening all relevant articles. The selected articles will be analysed via R Bibliometrix, a program for mathematical analysis of large sets of literature, and VOSviewer, which creates visual representations of connections between articles.
    ETHICS AND DISSEMINATION: This study did not require research ethics approval given the use of publicly available data and lack of human subjects. The results will be presented at scientific meetings and published in peer-reviewed journals.
    Keywords:  data science; deep learning; informatics; machine learning; medical informatics
    DOI:  https://doi.org/10.1136/bmjhci-2022-100594
  57. Eur Neuropsychopharmacol. 2022 Sep 30. pii: S0924-977X(22)00847-1. [Epub ahead of print]64 44-60
    A century of research on psychedelics: A scientometric analysis on trends and knowledge maps of hallucinogens, entactogens, entheogens and dissociative drugs.
    Marco Solmi, Chaomei Chen, Charles Daure, Anne Buot, Michael Ljuslin, Vincent Verroust, Luc Mallet, Yasser Khazaal, Stephane Rothen, Gabriel Thorens, Daniele Zullino, Gabriella Gobbi, Joshua Rosenblat, Muhammad Ishrat Husain, Danilo De Gregorio, David Castle, Michel Sabé.
      A scientometric analysis was realized to outline clinical research on psychedelics over the last century. Web of Science Core Collection was searched up to March 18, 2022, for publications on psychedelics. Network analyses and bibliometrics were combined, to identify research themes and trends with Bibliometrix and CiteSpace. The primary aim was to measure research trends evolution over time, and the secondary aims were to identify bibliometric performance and influence networks of publications, authors, institutions, and countries. Sensitivity analyses were conducted for 2016-2022, and 2021 time periods. We included 31,687 documents (591,329 references), which aggregated into a well-structured network with credible clustering. Research productivity was split into an early less productive period mainly focusing on safety issues, and a "psychedelic renaissance" after the 1990s. Major trends were identified for hallucinogens/entheogens, entactogens, novel psychoactive substances (NPS), and on dissociative substances. There was a translational evolution from the bench to the bedside, with phase 2 and 3 trials and/or evidence synthesis in particular. The most recent trends concerned NPS, ketamine-associated brain changes, and ayahuasca-assisted psychotherapy. The USA and Canada were the most productive settings for the research overall, and more recently this geographical distribution became more prominent, reflecting legislative context/policy making. A translational evolution of psychedelics has been occurring, that has brought approval of esketamine for depression and will likely lead to approval of additional psychedelics across mental and physical conditions. Toxicology screening tools for NPS are urgently needed, which in turn might follow the same translational evolution of psychedelics in the future.
    Keywords:  Bibliometrix; CiteSpace; Evidence synthesis; Mood disorders; New psychoactive substances; Therapeutic
    DOI:  https://doi.org/10.1016/j.euroneuro.2022.09.004
  58. J Med Internet Res. 2022 Oct 03. 24(10): e40011
    Tracking Openness and Topic Evolution of COVID-19 Publications January 2020-March 2021: Comprehensive Bibliometric and Topic Modeling Analysis.
    Maider San Torcuato, Núria Bautista-Puig, Olatz Arrizabalaga, Eva Méndez.
       BACKGROUND: The COVID-19 outbreak highlighted the importance of rapid access to research.
    OBJECTIVE: The aim of this study was to investigate research communication related to COVID-19, the level of openness of papers, and the main topics of research into this disease.
    METHODS: Open access (OA) uptake (typologies, license use) and the topic evolution of publications were analyzed from the start of the pandemic (January 1, 2020) until the end of a year of widespread lockdown (March 1, 2021).
    RESULTS: The sample included 95,605 publications; 94.1% were published in an OA form, 44% of which were published as Bronze OA. Among these OA publications, 42% do not have a license, which can limit the number of citations and thus the impact. Using a topic modeling approach, we found that articles in Hybrid and Green OA publications are more focused on patients and their effects, whereas the strategy to combat the pandemic adopted by different countries was the main topic of articles selecting publication via the Gold OA route.
    CONCLUSIONS: Although OA scientific production has increased, some weaknesses in OA practice, such as lack of licensing or under-researched topics, still hold back its effective use for further research.
    Keywords:  COVID-19; OA; SARS-CoV-2; accessibility; communication; dissemination; open access; publications; research; research topics; scholarly communication; scientometry; topic modeling
    DOI:  https://doi.org/10.2196/40011
  59. J Natl Med Assoc. 2022 Oct 03. pii: S0027-9684(22)00160-2. [Epub ahead of print]
    Trends in diversity, equity and inclusion publications in neurological journals: 2015-2020.
    Charles Esenwa, Nikunj K Patel, Mill Etienne, Elizabeth D Drugge, Emma Wallace, Bruce Ovbiagele.
       BACKGROUND: Contemporary information on health equity related efforts by scientific neurological journals, as measured by publications related to diversity, equity and inclusion (DEI) and health disparities related to social determinants of health (SDH) are lacking.
    OBJECTIVE: To assess the yearly rates of DEI and SDH related publications in the highest cited general neurology and neurological sub-specialty journals and compare them to the highest cited medical journals over a 6-year period.
    METHODS: We included publications from 15 general neurology and neurological subspecialty journals between January 1st 2015 to December 31st 2020. For comparison we included the 15 most cited medical journals as measured by H-Index. We performed a PubMed search in each of the listed journals using key MeSH terms. Two-proportions Z-test and chi-square trend analyses were used to compare differences between journal types.
    RESULTS: Total yearly proportion of DEI and SDH related publications in neurological journals was 3.9% compared to 6.2% in the highest cited medical journals for years 2015 to 2020 (p=0.001). There was no change in overall trend in publications related to DEI and SDH topics in neurological (ρ = -0.082, p=0.45) or highest cited medical journals between 2015 and 2020 (ρ = -0.065, p=0.54).
    CONCLUSION: Neurological journals had a significantly lower yearly proportion of DEI and SDH related publications compared to top-cited medical journals. Despite heightened awareness of racial/ethnic health disparities and inequities driven by SDH there was no change in related publications in neurological journals between 2015-2020.
    Keywords:  Equity; Journal publications; Neurology; Racial disparities; Racism
    DOI:  https://doi.org/10.1016/j.jnma.2022.09.008
  60. Plast Reconstr Surg Glob Open. 2022 Sep;10(9): e4506
    The Impact of Senior Author Profile on Publication Level of Evidence in Plastic and Reconstructive Surgery.
    Jessica D Blum, Anchith Kota, Dillan F Villavisanis, Daniel Y Cho, Jordan W Swanson, Scott P Bartlett, Jesse A Taylor.
      Plastic and Reconstructive Surgery (PRS) incorporated the level of evidence (LOE) pyramid in 2011 to highlight evidence-based medicine in plastic surgery. This study aimed to assess the relationship between the profile of senior authors publishing in PRS and the LOE of publications.
    Methods: All accepted publications by American senior authors to PRS between January 2018 and March 2020 were classified by LOE. Demographic, educational, and career data on all senior authors were collected using publicly available online resources.
    Results: A total of 1030 articles were screened' of which 266 (25.8%) were eligible for LOE classification with the following distribution: I, 0.8%; II, 14.3%; III, 45.1%; IV, 33.1%; and V, 7.1%. Senior author demographic factors, including gender and race/ethnicity, did not significantly impact LOE (P > 0.05 for all). An advanced degree was associated with more publications per year, and only a PhD (P = 0.022) and board certification (P = 0.012) were associated with a higher LOE of publications (P = 0.022). Physicians working in an academic setting were significantly more likely to publish level III evidence than their private/community-based counterparts (P = 0.006). Breast papers constituted the highest proportion of level III evidence (41.4%; P < 0.001).
    Conclusions: Most publications in PRS contain level III-IV evidence. Senior author gender, race, and ethnicity did not impact LOE of publications. Plastic surgery board certification, possession of a PhD, and academic practice setting were associated with higher LOE of publications.
    DOI:  https://doi.org/10.1097/GOX.0000000000004506
  61. Health Policy. 2022 Sep 28. pii: S0168-8510(22)00251-2. [Epub ahead of print]
    Academic Health Centers' configurations, scientific productivity, and impact: Insights from the Italian setting.
    Luca D'Aniello, Maria Spano, Corrado Cuccurullo, Massimo Aria.
      Academic Health Centers (AHCs) have an enormous impact on health, society, and national competitiveness. They have a threefold strategic mission and heterogeneous models of governance. Our aim is to investigate how different AHC configurations are associated with research performance. The method we adopted follows two steps. First, we identify organizational configurations through cluster analysis of nine variables. Second, we correlate these configurations to bibliometric measures of research outputs. Findings show that AHCs, that are specialty-focused and not mainly involved in educational activities are more productive and have more research impact than fully integrated and affiliated AHCs. Those AHCs also share secondary contextual features.
    Keywords:  Academic Health Centers; Health policy; Healthcare configurations; Research impact; Scientific productivity
    DOI:  https://doi.org/10.1016/j.healthpol.2022.09.007
  62. Chemosphere. 2022 Sep 28. pii: S0045-6535(22)03115-0. [Epub ahead of print]309(Pt 1): 136622
    A review on properties, challenges and commercial aspects of eco-friendly biolubricants productions.
    Uzair Ahmad, Salman Raza Naqvi, Imtiaz Ali, Muhammad Naqvi, Saira Asif, Awais Bokhari, Dagmar Juchelková, Jiří Jaromír Klemeš.
      Lubricants operate as antifriction media, preserving machine reliability, facilitating smooth operation, and reducing the likelihood of frequent breakdowns. The petroleum-based reserves are decreasing globally, leading to price increases and raising concerns about environmental degradation. The researchers are concentrating their efforts on developing and commercializing an environmentally friendly lubricant produced from renewable resources. Biolubricants derived from nonedible vegetable oils are environmentally favorable because of their non-toxicity, biodegradability, and close to net zero greenhouse gas emissions. The demand for bio lubricants in industry and other sectors is increasing due to their non-toxic, renewable, and environmentally friendly nature. Good lubrication, anti-corrosion, and high flammability are characteristic properties of vegetable oils due to their unique structure. This study presents several key properties of nonedible oils that are used to produce lubricants via the transesterification process. Bibliometric analysis is also performed, which provides us with a better understanding of previous studies related to the production of bio lubricants from the transesterification process. Only 371 published documents in the Scopus database were found to relate to the production of bio lubricants using the transesterification process. The published work was mostly dominated by research articles (286; 77.088%). Significant development can be seen in recent years, with the highest occurrence in 2021, reaching 68 publications accounting for 18.38% of the total documents. In the second step, (i) the authors with the most number of publications; (ii) journals with the most productions; (iii) most productive countries; and (iv) the authors' most frequently used keywords were evaluated. These results will provide a pathway for researchers interested in this field. Lastly, recommendation is made on research gaps to device possible strategies for its commercialization.
    Keywords:  Biolubricant; Challenges; Commercial aspects; Eco-friendly; Sustainable
    DOI:  https://doi.org/10.1016/j.chemosphere.2022.136622
  63. Environ Sci Pollut Res Int. 2022 Oct 05.
    Waste management and green technology: future trends in circular economy leading towards environmental sustainability.
    Muhammad Tanveer, Syed Abdul Rehman Khan, Muhammad Umar, Zhang Yu, Muhammad Jawad Sajid, Ikram Ul Haq.
      The effective treatment of waste to be used as a resource in future has a major role in achieving environmental sustainability and moving towards circular economy. The current research is aimed to provide in-depth detail regarding prominent trends and research themes, evolution, future research orientation, main characteristics, and mapping of research publications on waste management, technological innovation in circular economy domain from the year 2000 to 2021. Different analyses including text mining and bibliometric and content analyses were applied to answer the research question and provide the details on aforementioned variables. From the bibliometric analyses, a total of 1118 articles were drawn out from the Scopus database to conceptualize the core body of research. As a result, the following themes were identified: electronic waste, circular economy transition, plastic waste, bio-based waste management, lifecycle assessment, and ecological impacts, and construction and demolition waste management. The highlighted features, future research orientation, and prominent research perspective can provide guideline for future research to enrich the literature through conducting studies on provided research directions and help lead waste management and technological innovation policymakers, professionals, and practitioners in moving towards circular transition.
    Keywords:  Circular economy; Green technology; Responsible editor: Ilhan Ozturk; Technological innovation; Waste management
    DOI:  https://doi.org/10.1007/s11356-022-23238-8
  64. Front Public Health. 2022 ;10 985391
    The positive aspects of caregiving in dementia: A scoping review and bibliometric analysis.
    Jun Wang, Xuelian Li, Weichu Liu, Bing Yang, Qinghua Zhao, Yang Lü, Mingzhao Xiao.
       Purpose: The increasing incidence of dementia and home-based care exposes family caregivers to a variety of challenges as they endure strong stressors underlying the caregiver role. Despite growing publications on positive aspects of caregiving in dementia, few studies have identified the extent, nature, and gaps in the existing literature based on a holistic view. The aim was to identify key issues and a holistic view of literature regarding positive aspects of caregiving in dementia.
    Methods: A scoping review was conducted underlying a five-stage framework by Arksey and O'Malley. Five databases, including PubMed, CINAHL, PsycINFO, Embase, and Web of Science, were searched, and references were listed accordingly. Data were extracted by two researchers, comprising article characteristics, forms of positive aspects of caregiving and measurements, theories, forms of dementia and family caregiver, and keywords. Descriptive statistics and narrative synthesis were performed to analyze data. Network analysis of keywords and authors was conducted using VOSviewer software. Word cloud analysis of titles was examined by NVivo.
    Results: The review included 230 articles, most of which have been published in the last decade (62.61%). Most articles (40.00%) were contributed by the United States. Cross-sectional studies (41.30%) ranked first, followed by qualitative studies (13.48%). Over a quarter of the literature (28.26%) focused on Alzheimer's care, and nearly 90% included all forms of family caregivers. The Positive Aspects of Caregiving Scale and stress coping theory were most frequently cited. Four clusters dominated by Casey D, Quinn C, Joling KJ, and Teahan A were identified in the network of co-authorship. Six themes were identified: current situations of caregiver experiences, antecedents, consequences, measurement development, effects of interventions, and the concept of positive aspects of caregiving. These were in line with network analysis of keywords and word cloud analysis of titles.
    Conclusions: Positive aspects of caregiving in dementia have been widely concerned, but most of them are based on the theory of the negative stress process and are limited to current situations and influencing factors. Building theories focus on the positive aspects of caregiving, subsequently developing a comprehensive measurement and effective interventions, should be further studied.
    Keywords:  Alzheimer's disease; bibliometric analysis; dementia; positive aspects of caregiving; scoping review
    DOI:  https://doi.org/10.3389/fpubh.2022.985391
  65. Eur J Pharmacol. 2022 Sep 29. pii: S0014-2999(22)00560-X. [Epub ahead of print]934 175299
    Recent progress and research trend of anti-cataract pharmacology therapy: A bibliometric analysis and literature review.
    Ao Lu, Ping Duan, Jing Xie, Hui Gao, Mengmeng Chen, Yu Gong, Jiawen Li, Haiwei Xu.
      Cataract is the leading cause of blindness worldwide. Cataract phacoemulsification combined with intraocular lens implantation causes great burden to global healthcare, especially for low- and middle-income countries. Such burden would be significantly relieved if cataracts can effectively be treated or delayed by non-surgical means. Excitingly, novel drugs have been developed to treat cataracts in recent decades. For example, oxysterols are found to be able to innovatively reverse lens clouding, novel nanotechnology-loaded drugs improve anti-cataract pharmacological effect, and traditional Chinese medicine demonstrates promising therapeutic effects against cataracts. In the present review, we performed bibliometric analysis to provide an overview perspective regarding the research status, hot topics, and academic trends in the field of anti-cataract pharmacology therapy. We further reviewed the curative effects and molecular mechanisms of anti-cataract drugs such as lanosterol, metformin, resveratrol and curcumin, and prospected the possibility of their clinical application in future.
    Keywords:  Bibliometric analysis; Cataract; Chinese traditional medicine; Pharmacology
    DOI:  https://doi.org/10.1016/j.ejphar.2022.175299
  66. Int Neurourol J. 2022 Sep;26(3): 173-178
    A Discussion Between Past and Present Editor-in-Chief of the International Neurourology Journal: Three Decades of History.
    Jong Mok Park, Khae Hawn Kim.
      The International Neurourology Journal (Int Neurourol J, INJ) is a quarterly international journal that publishes high-quality research papers that provide the most significant and promising achievements in the fields of clinical neurourology and fundamental science. Specifically, fundamental science includes the most influential research papers from all fields of science and technology, revolutionizing what physicians and researchers practicing the art of neurourology worldwide know. Thus, we welcome valuable basic research articles to introduce cutting-edge translational research of fundamental sciences to clinical neurourology. In the editorials, urologists will present their perspectives on these articles. The original mission statement of the INJ was published on October 12, 1997. INJ provides authors a fast review of their work and makes a decision in an average of 3 to 4 weeks of receiving submissions. If accepted, articles are posted online in fully citable form. Supplementary issues will be published interim to quarterlies, as necessary, to fully allow berth to accept and publish relevant articles. Science Citation Index Expanded (SCIE, Web of Science), Scopus, PubMed, PubMed Central, KoreaMed, KoMCI, WPRIM, WorldWideScience.org, DOI/Crossref, EBSCO, Google Scholar.
    Keywords:  Editors-in-chief; Hisotory; International Neurourology Journal; Neurourology
    DOI:  https://doi.org/10.5213/inj.2244196.098
  67. Interact J Med Res. 2022 Oct 04. 11(2): e31055
    Trends in Health Quality-Related Publications Over the Past Three Decades: Systematic Review.
    Joseph Mendlovic, Francis B Mimouni, Iris Arad, Eyal Heiman.
       BACKGROUND: Quality assessment in health care is a process of planned activities with the ultimate goal of achieving a continuous improvement of medical care through the evaluation of structure, process, and outcome measures. Physicians and health care specialists involved with quality issues are faced with an enormous and nearly always increasing amount of literature to read and integrate. Nevertheless, the novelty and quality of these articles (in terms of evidence-based medicine) has not been systematically assessed and described.
    OBJECTIVE: The objective of this study was to test the hypothesis that the number of high-evidence journal articles (according to the pyramid of evidence), such as randomized control trials, systematic reviews, and ultimately, practice guidelines, increases over time, relative to lower-evidence journal articles, such as editorials, reviews, and letters to the editors.
    METHODS: We used PubMed database to retrieve relevant articles published during the 31-year period between January 1, 1989, and December 31, 2021. The search was conducted in April 2022. We used the keywords "quality care," "quality management," "quality indicators," and "quality improvement" and limited the search fields to title and abstract in order to limit our search results to articles nearly exclusively related to health care quality.
    RESULTS: During this 31-year evaluation period, there was a significant cubic increase in the total number of publications, reviews, clinical trials (peaking in 2017, with a sharp decline until 2021), controlled trials (peaking in 2016, with a sharp drop until 2021), randomized controlled trials (peaking in 2017, with a sharp drop until 2021), systematic reviews (nearly nonexistent in the 1980s through 1990s to a peak of 222 in 2021), and meta-analyses (from nearly none in the 1980s through 1990s to a peak of approximately 40 per year in 2020). There was a linear increase in practice guidelines from none during 1989-1991 to approximately 25 per year during 2019-2021, including a cubic increase in editorials, peaking in 2021 at 125 per year, and in letters to the editor, peaking at 50-78 per year in the last 4 years (ie, 2018-2021).
    CONCLUSIONS: Over the past 31 years, the field of quality in health care has seen a significant yearly increase of published original studies with a relative stagnation since 2015. We suggest that contributors to this dynamic field of research should focus on producing more evidence-based publications and guidelines.
    Keywords:  health quality; healthcare quality; medline; publication; quality assessmnet
    DOI:  https://doi.org/10.2196/31055
  68. J Orthop Trauma. 2022 Oct 01.
    Spin in the Abstracts of Meta-analyses and Systematic Reviews: Midshaft Clavicle Fracture.
    Matthew T Gulbrandsen, Ryan J Filler, R Casey Rice, Jun Ho Chung, Trevor R Gulbrandsen, Wesley P Phipatanakul, Joseph N Liu.
       OBJECTIVES: Spin is a reporting bias that presents the beneficial effect of an experimental treatment as greater than what is found in the results of the study. This bias can result in patient care recommendations that are more subjective than objective. The purpose of this study is to identify the prevalence of spin in meta-analysis and systematic review abstracts regarding treatment of midshaft clavicle fractures.
    METHODS: Electronic libraries (MEDLINE, Embase, Web of Science, Google Scholar) were systematically searched. Meta-analyses and systematic reviews regarding treatment of midshaft clavicular fractures were analyzed. The nine most severe types of spin commonly found in abstracts were used as an evaluation tool to assess the articles. Other variables analyzed include year of publication, journal impact factor, number of citations, and methodologic quality according to A Measurement Tool to Assess Systematic Reviews (AMSTAR-2).
    RESULTS: The database search resulted in 401 articles, of which 53 met inclusion criteria. After review, it was found that 52.8% (28/53) of the included articles contained spin within the abstract. Of the nine most severe types of spin found in abstracts, type 3 spin ("selective reporting of or overemphasis on efficacy outcomes or analysis favoring the beneficial effect of the experimental intervention") was found to be the most prevalent 28.3% (15/53).
    CONCLUSION: This study demonstrated the presence of spin in the majority of meta-analyses and systematic review abstracts pertaining to midshaft clavicular fractures. Orthopedic surgeons should be aware and recognize spin as they review articles when deciding the treatment course for such injuries.
    LEVEL OF EVIDENCE: Level 3. See Instructions for Authors for a complete description of levels of evidence.
    DOI:  https://doi.org/10.1097/BOT.0000000000002497
  69. Environ Sci Pollut Res Int. 2022 Oct 07.
    Environmental risk, toxicity, and biodegradation of polyethylene: a review.
    Dina M El-Sherif, Manal G Eloffy, Alaa Elmesery, Mohamed Abouzid, Mohammed Gad, Hesham R El-Seedi, Markus Brinkmann, Kai Wang, Yahya Al Naggar.
      Polyethylene is the second-most-commonly-used commercial polymer. It is used in various industries, including agricultural mulches, composite materials, and packaging. Since polyethylene is not biodegradable, it can persist for a long time in water and soil, strangling otherwise fruitful land. The ecological and toxicological consequences and the fate of polyethylene have only recently been revealed. As a result, the primary goal of this review is to shed light on the reported toxicity of polyethylene to the environment and living creatures and highlight recent research on its degradation process through bibliometric analysis. To do that, we searched Web of Science database literature up to August 2021 and performed the bibliometric analysis using VOSviewer. We found that relative research interest showed a positive trend, particularly in the last 5 years. China and the Chinese Academy of Sciences had the highest published papers. Methods for polyethylene biodegradation by invertebrates, bacteria, and fungi were also reported indicating the need for future research to investigate and develop new biodegradation technologies.
    Keywords:  Biodegradation; Human health; Microplastics; Occurrence and characterization; Plastic ingestion; Toxicities; Uptake by organisms
    DOI:  https://doi.org/10.1007/s11356-022-23382-1
  70. Front Rehabil Sci. 2022 ;3 849216
    Rehabilitation Research in Denmark Between 2001 and 2020: A Scoping Review.
    Anne-Mette Hedeager Momsen, Jasmine Charlotte Fox, Claus Vinther Nielsen, Jette Thuesen, Thomas Maribo.
      The demand for rehabilitation has increased, and evidence is rapidly growing; however, a rehabilitative health strategy receives less attention than treatment. Knowledge of what is being researched, who are the target groups and who contributes to rehabilitation research is deficient. We did not find any reviews mapping rehabilitation research regarding the research questions. The objective was to identify and synthesize existing scientific evidence on rehabilitation research published by Danish institutions between 2001 and 2021. The research questions to be explored were: Among which study groups has rehabilitation research been published?. Which types of studies on rehabilitation have been published?. Which institutions have been involved in rehabilitation research?
    Methods: The process was guided according to the Joanna Briggs Institute's (JBI's) scoping review methodology. Four databases were searched. All types of peer-reviewed studies on any target group and rehabilitation setting, with any affiliation to a Danish institution, were eligible to be included. Studies referring to population and the type of design were categorized. Institutions were counted as Danish first authorship.
    Results: The search revealed 3,100 studies, and following screening 1,779 were included. A total of 24 broad study groups were identified, mostly diagnosis-based health conditions. Musculoskeletal, cancer, and cardiac had 342, 228, and 174 studies, respectively. A total of 1,545 had a Danish first authorship, most of the Danish publications came from hospitals (56.6%) and universities (28.4%). The publication trend showed an almost linear development, with a 10-15% increase during the period.
    Conclusion: Following screening 1,779 studies were included involving 24 broad study groups. Most categories were diagnosis-based; musculoskeletal, cancer, and cardiac health conditions encompassed most studies. All study designs were represented, and 1/10 were secondary studies. The majority (87%) of studies had a Danish first authorship. The majority of first affiliations were among hospitals followed by universities. A few municipalities were presented although they are yet to have research responsibility. Publication trends showed an increase primarily from 2013.
    Systematic Review Registration: https://osf.io/, identifier [10.17605/OSF.IO/2AENX].
    Keywords:  Denmark; health condition; rehabilitation; rehabilitation research; research institutions; scoping review
    DOI:  https://doi.org/10.3389/fresc.2022.849216
  71. Front Microbiol. 2022 ;13 989580
    A decade after the first Pucciniales genomes: A bibliometric snapshot of (post) genomics studies in three model rust fungi.
    Benjamin Petre, Sébastien Duplessis.
      Pucciniales (rust fungi) are one of the largest fungal order of plant pathogens. They collectively infect key crops such as wheat and soybean, and threaten global food security. In the early 2010s, the genome sequences of three rust fungi were released: Melampsora larici-populina (the poplar leaf rust fungus), Puccinia graminis f. sp. tritici (the wheat stem rust fungus), and Puccinia striiformis f. sp. triciti (the wheat stripe rust or wheat yellow rust fungus). The availability of those genomes has forwarded rust biology into the post-genomic era, sparking a series of genomics, transcriptomics, in silico, and functional studies. Here, we snapshot the last 10 years of post-genomics studies addressing M. larici-populina, P. graminis f. sp. tritici, and/or P. striiformis f. sp. tritici. This mini-review notably reveals the model species-centered structure of the research community, and highlights the drastic increase of the number of functional studies focused on effectors since 2014, which notably revealed chloroplasts as a central host compartment targeted by rust fungi. This mini-review also discusses genomics-facilitated studies in other rust species, and emerging post-genomic research trends related to fully-phased rust genomes.
    Keywords:  basidiomycete; bibliometric analysis; fungal parasite; microbe; plant disease; plant pathology; transcriptome; virulence protein
    DOI:  https://doi.org/10.3389/fmicb.2022.989580
  72. Am J Orthod Dentofacial Orthop. 2022 Oct 04. pii: S0889-5406(22)00575-3. [Epub ahead of print]
    The clear reporting of study limitations in the reports of orthodontic randomized controlled trials is not routinely undertaken: A systematic search and review.
    Marianna Koufatzidou, Ilias Karveleas, Jadbinder Seehra, Nikolaos Pandis.
       INTRODUCTION: To ensure accurate interpretation of the generalizability of trial findings, the clear reporting of limitations is imperative. This review aimed to assess whether study limitations are reported in full-text articles of orthodontic randomized controlled trials (RCTs). Associations between the trial characteristics and the reporting of limitations were also explored.
    METHODS: In this review, RCTs published between January 1, 2011 and December 31, 2021 were identified from 5 orthodontic journals with the highest impact factor. Trial characteristics were extracted from the individual reports. To ascertain if limitations were reported in reports of RCTs, a criterion was developed from previously published literature. Descriptive statistics and associations between the reporting of limitations and trial characteristics were explored.
    RESULTS: Three hundred and eighty-six trials were analyzed. In relation to the criterion, the clear reporting of trial limitations was deficient across several areas. Most RCTs were published in 2021 (12.7%), had authors based in Asia and other regions (42.2%), did not have a statistician involved (85.8%), and were materials and devices type trials (48.7%). An association was detected between the year of publication, impact factor, journal and journal submission instructions, and reporting of study limitations. More recent trials published in journals with higher impact factors were more likely to report limitations in the main manuscript. Journals with suggested or mandatory instructions were more likely to report limitations in the trials they publish than journals with no reference to reporting limitations in the manuscript in the journal submission instructions.
    CONCLUSIONS: Authors of trials should not view the reporting of limitations as a weakness of their trial but rather as an opportunity to provide further information to allow clinicians to fully interpret the generalizability of the results. Scientific journals should stipulate and facilitate the reporting of study limitations within manuscripts.
    DOI:  https://doi.org/10.1016/j.ajodo.2022.08.016
  73. JAMA Netw Open. 2022 Oct 03. 5(10): e2234585
    Characteristics of Retracted Research Articles About COVID-19 vs Other Topics.
    Xiaoting Shi, Alison Abritis, Rujvee P Patel, Mikas Grewal, Ivan Oransky, Joseph S Ross, Joshua D Wallach.
      
    DOI:  https://doi.org/10.1001/jamanetworkopen.2022.34585
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