bims-evares Biomed News
on Evaluation of research
Issue of 2022–05–22
forty-nine papers selected by
Thomas Krichel, Open Library Society



  1. Nurse Educ Today. 2022 Apr 30. pii: S0260-6917(22)00121-6. [Epub ahead of print]114 105385
       OBJECTIVES: Bibliometrics is an emerging science in nursing. Quantitative methods were used to conduct a bibliometric analysis of highly cited virtual simulation nursing education articles to describe rank order, breadth of topics and authorship patterns.
    DESIGN AND DATA SOURCES: A desktop analysis of publication performance was conducted using the Scopus database as the source of article citation data.
    RESULTS AND DISCUSSION: The top 100 cited articles clustered over 14-years, 2008 to 2021. Citations per paper ranged from 88 to a low of 3 (median 18, mean 22.1) and in the top 10 studies, from 88 to 41. The citation trajectory was moderately correlated with article maturity (r = -.384, p ≤0.001). Article citations in subsequent publications commenced the first year after publication and three-year-old papers reached the mean citation rate of 22. Nurse Education Today was the most cited journal. There was no significant impact of article type (72% primary research, 17% literature reviews, 11% descriptive papers) (p = 0.755). International representation was strong, as first authors in 21 countries were cited - many (43%) from USA. One highly cited author (M. Verkuyl) from Canada led six papers, with six other authors each leading two studies. Virtual simulation modalities included virtual simulation, virtual reality simulation, 3D virtual reality simulation, virtual games and virtual worlds. The top 10 articles offer a diverse resource for faculty and educators who wish to consider using virtual simulation.
    CONCLUSION: Virtual simulation studies in nursing education cover an emerging field of research that has relatively low citation rates. Nursing researchers and faculty need to understand the usefulness and limitations of bibliometric analysis as this methodology can make a unique contribution to research, policy, and funding decisions, and enable productivity assessments of faculty staff and departments.
    Keywords:  Bibliometrics; Computer simulation; Nurse education; Research; Virtual simulation
    DOI:  https://doi.org/10.1016/j.nedt.2022.105385
  2. Front Oral Health. 2022 ;3 864519
       Background: The aim of this bibliometric research was to identify and analyze the top 100 cited publications in the field of temporomandibular disorders (TMD) in order to guide any professional level with interest in this topic by mapping the current trends in the field of TMD.
    Materials and Methods: The Clarivate Analytics' Web of Science database was used to find the top 100 most cited papers in the field of TMD, published from the year 2000 to November 18, 2021, with MeSH terms in the search strategy. Data extracted were ranking, title, main author, institution, publication year, a total of citations, citation average per year, the journal the study was published, journal impact factor, and the number of studies that each journal published. Further, also the percentage of the different study designs, the number of studies regarding a specific area within the field of TMD, and the number of studies per country were also calculated. A ranking of authors was also performed.
    Results: The top cited paper was a study on diagnostic criteria for TMD, with 1,287 citations published in 2014 in the Journal of Oral and Facial Pain and Headache which also had most of the top 100 cited publications. Eighty-one percent of the most cited studies were from the USA and Europe and 33% of the included studies were review articles.
    Conclusion: Taken together, since all papers were considered classic, one can draw the conclusion that researchers in 2000 onward in the field of TMD are interested in (a) diagnostic criteria, (b) TMD symptoms and mainly pain-related symptoms, (c) etiology and risk factors of TMD and mainly bruxism, and (d) treatment of TMD. However, topics such as imaging, occlusion, tissue engineering, and disk displacements are presently not as popular.
    Keywords:  bibliometric analyses; citation; etiology; temporomandibular disorders; temporomandibular joint
    DOI:  https://doi.org/10.3389/froh.2022.864519
  3. J Thorac Dis. 2022 Apr;14(4): 1212-1224
       Background: After cardiac surgery, patients are often admitted to the intensive care unit (ICU) due to various preoperative factors and continue to receive mechanical ventilation. This study sought to conduct a bibliometric analysis to summarize studies on mechanical ventilation among postoperative ICU patients who had undergone cardiac surgery.
    Methods: We searched the Science Citation Index Expanded (SCI-E) database using the following terms: "cardiac surgery (Topic)", "intensive care (Topic)" and "ventilation (Topic)". The search results were analyzed using R software. The analysis examined the number of publications of relevant articles and the annual change trend, the number of times an article was cited and the annual change trend, the distribution of countries conducting the research, the cooperation between countries and the citation frequency, the distribution of institutions conducting research, the cooperation between institutions, and the citation frequency, the number of published articles, the cooperation among researchers, and the citations frequency of researchers, the journals in which the articles were published, and the use of keywords.
    Results: A total of 1,969 relevant research papers were included in this study. The main countries that conducted the relevant research included the United States (US), China, Germany, and Canada. The research institutions were mainly located in the US and Canada, and the main researchers were from research institutions in these countries. The most cited authors were Zappitelli, Hichey, and Wypij. According to Bradford's law, 9 core journals in this field were identified. The results of the keyword analysis showed that in the past 10 years, research has focused on the mortality of patients, but only a few related random controlled trials have been conducted.
    Conclusions: More randomized controlled trials need to be conducted in this field to provide higher evidence-based medical evidence.
    Keywords:  Cardiac surgery; bibliometric analysis; intensive care unit (ICU); mechanical ventilation
    DOI:  https://doi.org/10.21037/jtd-22-233
  4. Front Med (Lausanne). 2022 ;9 820706
       Objective: The aim of this study was to explore hotspots and global research trends on optical coherence tomography (OCT) in the ophthalmic imaging field using the bibliometric technique.
    Methods: Documents related to OCT in the ophthalmic imaging field between 2011 and 2020 were extracted from the Science Citation Index (SCI) Expanded database. Downloaded raw data were analyzed using the VOSviewer and CiteSpace software. Bibliometric networks, including publication number per year, countries, authors, journals, international collaborations, and keywords were constructed.
    Results: A total of 4,270 peer-reviewed documents were retrieved, and annual research output in the past 10 years has increased significantly. The largest publishing country was the United States, and the most productive journal was Investigative Ophthalmology and Visual Science (IOVS). The most active academic institution was the University of California, Los Angeles, and the top rank publishing author was Duker JS. The most co-cited references mainly focused on new emerging OCT techniques such as spectral domain optical coherence tomography (SD-OCT) and optical coherence tomography angiography (OCTA).
    Conclusion: The bibliometric analysis of development trends on OCT in the ophthalmic imaging field on various aspects could provide developers or researchers with valuable information to propose future research directions and to pursue further cooperation.
    Keywords:  OCTA; VOSviewer; bibliometric analysis; ophthalmology (MeSH); optical coherence tomography (OCT)
    DOI:  https://doi.org/10.3389/fmed.2022.820706
  5. J Orthop. 2022 Jul-Aug;32:32 1-6
       Purpose: To carry out a bibliometric analysis of the scientific articles that address the topic of arthroscopy of the anterior cruciate ligament (ACL).
    Methods: A bibliographic search of the original articles published in orthopedics journals indexed in the Web of Science database until 2020 was carried out. Evaluation of compliance with the inclusion criteria was carried out in the Rayyan web application. The Bibliometrix package in the R programming language and VOSviewer were used to perform the bibliometric analysis.
    Results: 2249 articles published in 87 journals were included. The first publication on the subject was in 1980, and the highest number of publications was registered in 2020 (151) (annual percentage growth rate of 5.7). Fu FH was the author with the highest number of published articles, and the institutional affiliation with the highest number of original articles was the University of Pittsburgh. The most cited article was the study by Peterson et al. (2000) and the journal with the highest number of publications was Arthroscopy: the journal of arthroscopic and related surgery. United States had the highest frequency of publications and the highest number of total citations received by country. It was found on the network that the largest number of published studies had keywords such as: injuries and follow-up, whereas, in the most recent articles, the most common terms were risk-factors and outcomes.
    Conclusions: There is a sustained increase in scientific production on ACL arthroscopy among the world scientific community. Our results can be used for collaborative research purposes and by professionals seeking training in this topic.
    Keywords:  Anterior cruciate ligament; Arthroscopy; Bibliometrics; Orthopedics; Trends
    DOI:  https://doi.org/10.1016/j.jor.2022.04.019
  6. Front Cell Infect Microbiol. 2022 ;12 856845
       Introduction: Rapid, sensitive, and specific laboratory assays are critical for the diagnosis and management of central nervous system (CNS) infections. The purpose of this study is to explore the intellectual landscape of research investigating methods for the detection of pathogens in patients with CNS infections and to identify the development trends and research frontier in this field.
    Methods: A bibliometric study is conducted by analyzing literature retrieved from the Web of Science (WoS) Core Collection Database for the years 2000 to 2021. CiteSpace software is used for bibliometric analysis and network visualization, including co-citation analysis of references, co-occurrence analysis of keywords, and cooperation network analysis of authors, institutions, and countries/regions.
    Results: A total of 2,282 publications are eventually screened, with an upward trend in the number of publications per year. The majority of papers are attributed to the disciplines of MICROBIOLOGY, INFECTIOUS DISEASES, IMMUNOLOGY, NEUROSCIENCES & NEUROLOGY, and VIROLOGY. The co-citation analysis of references shows that recent research has focused on the largest cluster "metagenomic next-generation sequencing"; the results of the analysis of the highest-cited publications and the citation burst of publications reveal that there is a strong interest stimulated in metagenomic next-generation sequencing. The co-occurrence analysis of keywords indicates that "infection", "pathogen", "diagnosis", "gene", "virus", "polymerase chain reaction", "cerebrospinal fluid", "epidemiology", and "metagenomic next-generation sequencing" are the main research priorities in the field of pathogen detection for CNS infections, and the keyword with the highest strength of burst is "metagenomic next-generation sequencing". Collaborative network analysis reveals that the USA, the Centers for Disease Control and Prevention of USA, and XIN WANG and JENNIFER DIEN BARD are the most influential country, institution, and researchers, respectively.
    Conclusions: Exploring more advanced laboratory assays to improve the diagnostic accuracy of pathogens is essential for CNS infection research. Metagenomic next-generation sequencing is emerging as a novel useful unbiased approach for diagnosing infectious diseases of the CNS.
    Keywords:  CiteSpace; bibliometrics (source: MeSH NLM); central nervous system infections; metagenomic next-generation sequencing (mNGS); pathogen detection
    DOI:  https://doi.org/10.3389/fcimb.2022.856845
  7. Turk Thorac J. 2022 May;23(3): 246-256
       OBJECTIVE: Tuberculosis continues to become a serious public-health concern in many countries despite efforts to prevent and control global tuberculosis infections.
    MATERIAL AND METHODS: This study aims to present bibliometric analysis of the period 1849-2020 tuberculosis publications that are published by global researchers and indexed in the Scopus database. Although many studies have been carried out on tuberculosis, there is no study that performs bibliometric analysis of publications in this field in such a wide range of dates. Tuberculosis publications searched in the Scopus database between the period 1849-2020 were analyzed. Data on tuberculosis were presented by analyzing the number of publications, the language of publication, the countries that contribute the most to the literature, the most active institutions, the most cited publications, active authors and active journals, using appropriate quantitative and qualitative bibliometric indicators.
    RESULTS: 263,234 articles, published between 1849 and 2020 and searched in the Scopus database, were evaluated. The most articles (n= 8.344) were published in 2020. A total of 112,121 articles were published between 2001 and 2020. The most used publication lan- guage in the articles was English (62.48%), followed by Russian (7.25%). The country that contributed the most to the literature was the United States (13.81%), followed by India (7.18%). 3.9% of the articles were published in the journal "Tuberculosis and Lung Diseases".
    CONCLUSION: The results of the present bibliometric study are expected to shed light on the planning of future tuberculosis studies and the development of health policies toward tuberculosis. Research output is low in some countries, which should make larger investments in international and national collaborative research projects in the field of tuberculosis. If doing so, many countries of limited source will benefit from research that offer novel diagnostic and screening technology of tuberculosis.
    DOI:  https://doi.org/10.5152/TurkThoracJ.2022.21284
  8. Physiother Theory Pract. 2022 May 19. 1-13
       OBJECTIVES: The objectives of the study were: 1) Describe the thematic structure and evolution of the field of physical therapy; 2) identify the main research producers (i.e. countries and institutions); and 3) compare their research output and citation impact.
    METHODS: Papers related to physical therapy indexed in Web of Science (2000-2018) were identified to delineate the field, using keywords, journals, and citation networks. VOSviewer software, advanced bibliometric text mining, and visualization techniques were used to evaluate the thematic structure. We collected data about the country and institutional affiliation of all the authors and calculated production and citation impact indicators.
    RESULTS: 85,697 papers were analyzed. Eleven thematic clusters were identified: 1) "health care and education"; 2) "biomechanics"; 3) "psychosocial, chronic pain and quality of life outcomes"; 4) "evidence-based physical therapy research methods"; 5) "traumatology and orthopedics"; 6) "neurological rehabilitation"; 7) "psychometrics and cross-cultural adaptation"; 8) "gait-balance analysis and Parkinson's disease"; 9) "exercise"; 10) "respiratory physical therapy"; and 11) "back pain." The United States, the United Kingdom, and Australia were the most productive countries. Netherlands, Norway, and Sweden had the highest citation impact.
    CONCLUSIONS: Our bibliometric visualization approach makes it possible to comprehensively study the thematic structure of physical therapy. The ranking of producers has evolved and now includes China and Brazil. High research production does not imply a high citation impact.
    Keywords:  Bibliometrics; physical therapy; scientific impact; scientific production; thematic structure
    DOI:  https://doi.org/10.1080/09593985.2022.2073927
  9. J Pain Res. 2022 ;15 1365-1377
       Objective: Surface electromyography (sEMG) has been widely applied to rehabilitation medicine. However, the bibliometric analysis of the rehabilitation medicine use of sEMG is vastly unknown. Therefore, this research aimed to investigate the current trends of the rehabilitation medicine use of sEMG in the recent 12 years by using CiteSpace (5.8).
    Methods: Literature relating to rehabilitation medicine use of sEMG from 2010 to 2021 was retrieved from the Web of Science. CiteSpace analyzed country, institution, cited journals, authors, cited references and keywords. An analysis of counts and centrality was used to reveal publication outputs, countries, institutions, core journals, active authors, foundation references, hot topics and frontiers.
    Results: A total of 1949 publications were retrieved from 2010 to 2021. The total number of publications continually increased over the past 12 years, and the most active countries, institutions, journals and authors in rehabilitation medicine use of sEMG were identified. The most productive country and institution in this field were America (484) and the University of Sao Paulo (36). Andersen LL (28) was the most prolific author, and Dario Farina ranked first among the cited authors. Besides, there were three main frontiers in keywords for sEMG research, including "activation", "exercise", and "strength".
    Conclusion: The findings from this bibliometric study provide the current status and trends in clinical research of rehabilitation medicine use of sEMG over the past ten years, which may help researchers identify hot topics and explore new directions for future research in this field.
    Keywords:  CiteSpace; bibliometric analysis; rehabilitation medicine; surface electromyography
    DOI:  https://doi.org/10.2147/JPR.S364977
  10. Ann Transl Med. 2022 Apr;10(8): 484
       Background: Anal disease has a significant impact on patients' quality of life (QoL), and surgical treatment may further diminish QoL. The purpose of this study was to conduct bibliometric analysis to investigate the profile of studies on anorectal disease-related QoL.
    Methods: The database of Science Citation Index Expanded (SCI-E) in Web of Science Core Collection (WOSCC) was searched. The search terms were "anal diseases" and "quality of life". The bibliometrix package of R software was used to analyze the literature on anorectal diseases and QoL. The content of the analysis included the following: the number of papers published in this field by each country, the cooperation relationship between countries, the number of papers published by institutions, the cooperation relationship between institutions, the number of papers published by researchers, the cooperation relationship between researchers, the citations of researchers, the number of articles published in journals, and the use of keywords.
    Results: A total of 1,130 related research literature records were retrieved in this study. An annually increasing trend was detected in the number of published papers and the number of citations. Developed countries in Europe and America, mainly the United States, the United Kingdom (UK), and Germany, were in a leading position in this field. The Cleveland Clinic Foundation and Mayo Clinic in the United States, St. Mark's Hospital in the UK, and the University of Toronto in Canada were the leading research institutions in this field. The top 3 researchers with the most published papers were Feza H. Remzi, Bo Shen, and Victor W. Fazio. Collaboration among researchers was clustered. There were more high-quality related articles in professional journals of anal diseases. The use of keywords suggested a temporal change in research focus, but randomized controlled studies were found to be lacking.
    Conclusions: Asian countries should participate in more collaborative research projects in the field of anorectal disease, and more randomized controlled studies should be conducted overall.
    Keywords:  Anal disease; bibliometric research; quality of life (QoL)
    DOI:  https://doi.org/10.21037/atm-22-1372
  11. Ir Med J. 2020 Jul 30. 113(7): 125
      Identifying citation classics is a valuable metric of research performance. Ireland has a distinguished history of medical research, although Ireland's top-cited articles are unknown. The SCOPUS database identified all medical and surgical articles published by journals in the Republic of Ireland or Northern Ireland. The 100 top-cited articles were analysed. The most cited article received 240 citations. There is an observed trend of increasing number of authors over time (p<0.05). General medicine and public health are the most common topics. The majority of works originate from Irish institutions. Collaborative research and non-Irish research are poorly represented among the citation classics. The Irish medical literature contains multiple highly cited and influential articles.
  12. Comput Biol Med. 2022 Apr 29. pii: S0010-4825(22)00357-2. [Epub ahead of print]146 105565
      Diffuse large B-cell lymphoma (DLBCL) is a subtype of non-Hodgkin lymphoma (NHL) with the highest incidence, accounting for approximately one-third of NHL cases. Given the accumulated scientific publications related to the DLBCL domain, this study aimed to provide a comprehensive review of DLBCL studies from this millennium using the bibliometric method. With a strict retrieval strategy applied in the Web of Science database, a total of 10,869 publications from 2001 to 2020 were obtained and exported. The temporal and geographical distribution of these publications and the performance of contributing countries, institutions, journals, and authors corresponding to these documents were investigated, as well as an in-depth content analysis through keyword co-occurrence. With regard to the most productive countries, the United States ranks first with 2344 (21.6%) publications and shows the most frequent collaborations with other countries. By contrast, China has demonstrated remarkable performance in the growth rate of publications over the years, and it ranks first in the number of publications in the last five years. The University of Texas System is the institution with the highest number of published articles (4.99%). Leukemia Lymphoma is the journal with the highest number of publications in this field which contributed 588 articles. Solid and close collaborations between scholars are becoming more frequent over the four five-year periods. Overall, the highest cooperation frequency in the last two decades happens to Gascoyne RD at the British Columbia Cancer Agency and British Columbia Cancer Research Center in Canada. By comparing the article citation and keyword co-occurrence in each five-year period, as well as the changes in keyword clusters over two decades, we conclude that the stage, evaluation, prognosis, and treatment of DLBCL have always been the research hotspots in this field. Meanwhile, the evolution of keyword co-occurrence over the years demonstrates that new clusters appear. For instance, the effect of ferroptosis mechanism in DLBCL, immunotherapy for DLBCL, and PDL-1, PDL-2, and CAR-T therapy have drawn increasing attention from academia. Our research highlights the key characteristics of DLBCL research and provides comprehensive insights into the research status and evolutions in this field.
    Keywords:  Bibliometric; Diffuse large B-Cell lymphoma; Keyword co-occurrence; Web of science
    DOI:  https://doi.org/10.1016/j.compbiomed.2022.105565
  13. Front Surg. 2022 ;9 881555
       Background: Hip fractures are a common type of fracture in the elderly and are characterized by many complications and high mortality. Many topics concerning postoperative rehabilitation of hip fracture in elderly people still remain controversial, and the global research trend in this field has not yet been well studied. The aim of the present study was to illustrate the overall knowledge structure, development trends, and research hot spots of postoperative rehabilitation of hip fracture in elderly people.
    Methods: Articles and reviews regarding postoperative rehabilitation of hip fracture in elderly people from 2001 to 2021 were identified from the Web of Science database. An online bibliometric platform, CiteSpace, and VOSviewer software were used to generate visualization knowledge maps, including annual trends of publications, contributions of countries, institutions, authors, funding agencies, and journals, and clustering of keywords.
    Results: A total of 1,724 publications were identified from Web of Science Core Collection (WoSCC). In the past 20 years, the number of published studies on the rehabilitation of hip fracture in the elderly has exhibited an overall upward trend. The USA was the leading contributor in this field, with the largest number of publications (354, 20.65%) and the most citations (13,786 times). The international cooperation map among relevant countries/regions indicated that the USA collaborated most closely with Canada and China. The University of Maryland and Professor Marcantonio were the most prolific institution and influential author, respectively. Injury: International Journal of the Care of the Injured was the most productive journal concerning the research of postoperative rehabilitation of hip fracture in elderly people. The keyword co-occurrence analysis identified six clusters: quality of life study, rehabilitation and outcomes study, cognitive impairment study, operative approaches study, mortality study, and osteoporosis study.
    Conclusions: There will be an increasing number of publications on the research of postoperative rehabilitation of hip fracture in elderly people, and the United States will stay ahead in this field. Our findings could offer practical sources for scholars to understand the current status and trend of studies on rehabilitation of hip fracture in the elderly and provide references and suggestions for the development of related research in future.
    Keywords:  bibliometric analysis; hip fracture; hotspots; postoperative rehabilitation; research trends
    DOI:  https://doi.org/10.3389/fsurg.2022.881555
  14. Front Public Health. 2022 ;10 773668
       Background: Health policy and services is a continuously evolving field of research that can inform prevention and control efforts for a variety of health conditions. The "Healthy China" strategy reflects the demand to formulate health policy that suits China's national needs and goals. Applying bibliometric analysis to grasp the general situation of health policy and services research globally will be conducive to informing China's designated health plans and initiatives.
    Method: A bibliometric analysis of 58,065 articles on "Health Policy and Services" topics was conducted. The document type was restricted to journal articles that were published in the Web of Science database between the time parameter of January 1, 2009 to December 31, 2018. Data was collected on indicators such as the annual number of publications in the field of health policy and services, the country where the publication is issued, the publication organization, the source journal, the frequency of citations, research hotspots, and academic areas.
    Results: The overall number of articles published in Web of Science on health policy and services research has increased over time. The United States has the largest number of articles in the field. The institution with the highest number of citations in the field is Harvard University and the journal with the most published articles in the field is Health Affairs. Research hotspots in the health policy and services field include topics such as "HIV Infections," "Primary Health Care," "Delivery of Health Care," and "Health Services Accessibility."
    Conclusion: Experts in the field of health policy and services globally are dedicated to researching the most effective ways to improve people's health and living standards. There is a certain gap in the depth of health policy and services research between China and developed countries and regions such as Europe or America. China must learn from foreign experience to conduct meaningful and informative research that can aid in the formulation of multi-dimensional health policies in specific areas such as environmental infectious diseases, where attention is needed in areas beyond the medical and health system.
    Keywords:  bibliometric analysis; health policy; health services; research hotpots; research trends
    DOI:  https://doi.org/10.3389/fpubh.2022.773668
  15. Front Cardiovasc Med. 2022 ;9 882660
       Background: There is considerable research value and extensive application perspectives to explore the link between gut microbiota and heart failure. The purpose of this study is to provide an overview of overall characteristics, evolutionary pathways, frontier research hotspots, and future trends in this field.
    Methods: Research datasets were acquired from the Web of Science Core Collection (WoSCC) between January 1, 2006 and December 31, 2021. Three different analysis tools including one online platform, VOS viewer V1.6.17.0, and CiteSpace V5.8.R2 software were used in order to conduct collaboration network analysis, co-cited analysis, co-occurring analysis, and citation burst detection.
    Results: A total of 873 publications in the WoSCC database met the requirement. The overall characteristics analysis showed that a steady growth trend in the number of publications and citations, with the predominant literature type being articles and the most frequent subject category being cardiac cardiovascular systems. The United States was the most prolific country and the center of national collaboration. Cleveland Clinic and Nathalie M. Delzenne provided the leading influence with publications, the cooperation between the institutes and authors were relatively weak. Moreover, gut microbiota, heart failure, risk factor, obesity, and inflammation were the keywords that appeared more frequently in the clustering analysis of reference co-citation and keyword co-occurrence. Burst detection analysis of top keywords showed that trimethylamine N-oxide (TMAO), bile acid, blood pressure, hypertension, and fermentation were the new research foci on the association between gut microbiota and heart failure. Strategies to improve gut microbiota hold promise as a new approach to treat heart failure.
    Conclusion: The comprehensive bibliometric study indicates that the structured information may be helpful in understanding research trends in the link between gut microbiota and heart failure, and locating research hotspots and gaps in this domain, especially further advances in this field will lead to significant breakthroughs in the development of novel therapeutic tools for metabolic modulation of heart failure.
    Keywords:  CiteSpace; VOS viewer; frontier research hotspots; gut microbiota; heart failure; scientometric
    DOI:  https://doi.org/10.3389/fcvm.2022.882660
  16. Front Neurol. 2022 ;13 893121
       Background: Stroke is the second leading cause of death world-wide. A comprehensive scientometric study regarding ischemic stroke research has not been performed yet. This study aims at investigating the global research output on ischemic stroke research.
    Methods: All 21,115 articles regarding ischemic stroke were retrieved from the Web-of-Science-Core-Collection and analyzed regarding regional differences, the authors' sex, subtopics of stroke, as well as international research collaborations.
    Results: A total of 132 different countries participated, with the USA contributing most publications with 4,614 (21.9%), followed by China with 3,872 (18.3%), and Germany with 1,120 (5.3%). Analyzing the scientific quality of different countries by H-index, the USA ranked first with an H-index of 202, followed by Germany (H-index 135) and the United Kingdom (UK;H-index 129). The most frequently used topic was "Clinical Neurology" with 9,028 publications. Among all first authors attributed to their sex, 32.3% of all first authors were female and 67.7% were male (4,335 vs. 9,097). The proportion of female last authors was comparatively lower at 22.4% (3,083 publications) compared with 77.6% male authors (10,658 publications). There was a broad network of international collaborations.
    Conclusions: Research in ischemic stroke has substantially increased over time. Scientists from the USA have the highest number of publications, followed by China and Germany. Measured by the H-index, the USA held the highest publication quality, followed by Germany and the UK. The scientific landscape was male-dominated with 67.7% of all first authors being male. Worldwide international collaborations play a major role in ischemic stroke research.
    Keywords:  citation analysis; hemorrhagic; ischemic; research; stroke
    DOI:  https://doi.org/10.3389/fneur.2022.893121
  17. Front Psychiatry. 2022 ;13 860758
       Background: As a serious public health problem, dementia has placed a heavy burden on society and families. Evidence suggests that the use of music therapy as a non-pharmacological intervention has certain advantages with respect to reducing the behavioral and psychological symptoms of dementia (BPSD) and improving the cognition and mental status of dementia patients. However, research trends and hotspots regarding music therapy intervention for dementia analysis have not been systematically studied via bibliometric analysis.
    Methods: We searched the Web of Science Core Collection (WoSCC) for texts published between January 1, 2010, and October 31, 2021, and visualized country, institution, journal, keyword co-occurrence, keyword emergence and keyword clustering.
    Results: A total of 217 articles from the WoSCC database were analyzed. In this research field, the annual number of publications has generally shown a slowly increasing trend, and the United States has the most publications and the most frequent cooperation among countries. University College London (UCL) has the most extensive influence among research institutions. Among articles, those published in the JOURNAL OF ALZHEIMER'S DISEASE were the most numerous, with 20 such articles being published, accounting for 9.22% (20/217) of the total. Comprehensive analysis of five clusters via biclustering shows that the research hotspots in this field during the past 11 years have mainly focused on the autobiographical memory, cognitive function, mental state and BPSD of dementia patients.
    Conclusion: This study conducted a bibliometric and visual analysis of relevant studies concerning music therapy intervention for dementia patients. Psychological problems faced by dementia patients and the topics of quality of life, individualized music therapy, the mental state of caregivers and other related topics may be important research directions in the future. Therefore, the question of how to develop standardized research protocols and identify unified efficacy evaluation indicators should be a focus of and difficulty for future research.
    Keywords:  CiteSpace; Web of Science; bibliometric analysis; biclustering analysis; dementia; music therapy; research hotspots
    DOI:  https://doi.org/10.3389/fpsyt.2022.860758
  18. Front Aging Neurosci. 2022 ;14 876159
       Objectives: This study aimed to profile the cognitive aging research landscape from 1956 to 2021.
    Methods: A total of 3,779 documents were retrieved from the Scopus database for the bibliometric analysis and network visualization. By comparing each keyword's overall connection strength (centrality), frequency (density), and average year of publication (novelty) to the calculated median values acquired from the overlay view of the VOSviewer map, the enhanced strategic diagrams (ESDs) were constructed.
    Results: The findings showed an increasing trend in the number of publications. The United States leads the contributing countries in cognitive aging research. The scientific productivity pattern obeyed Lotka's law. The most productive researcher was Deary, I. J., with the highest number of publications. The collaborative index showed an increasing trend from 1980 onwards. Frontiers in Aging Neuroscience is the most prestigious journal in the field of cognitive aging research. In Bradford core journals zone 1, the top 10 core journals of cognitive aging research provided more than half of the total articles (697, or 55.36 percent).
    Conclusions: For the next decades, the trending topics in cognitive aging research include neuropsychological assessment, functional connectivity, human immunodeficiency virus (HIV), decision-making, gender, compensation, default mode network, learning and memory, brain-derived neurotrophic factor (BDNF), obesity, D-galactose, epigenetics, frailty, mortality, mini-mental state examination (MMSE), anxiety, and gait speed.
    Keywords:  BibliometriX R; Harzing’s publish or perish; VOSviewer; aging; cognition; enhanced strategic diagram
    DOI:  https://doi.org/10.3389/fnagi.2022.876159
  19. Int Dent J. 2022 Apr 14. pii: S0020-6539(22)00077-6. [Epub ahead of print]
       INTRODUCTION: Scientometrics is a discipline that allows the analysis of the characteristics of publications in each field of knowledge using different indicators. The aim of this research was to analyse world scientific publication as to COVID-19 related to dentistry.
    METHODS: A specialised search strategy was used to obtain all the documents published in journals indexed in the Scopus database between December 2019 and February 2022. The study variables were exported and analysed in SciVal (Elsevier).
    RESULTS: In all, 2071 documents were retrieved; of those, Oral Diseases has the highest impact with an average of 12.3 citations per publication, and the British Medical Journal was identified as the journal with the highest scientific output (107). India (292) and the UK (287) were the countries with the most published papers. The Universidade de São Paulo in Brazil was the institution with the highest number of published papers (61) and with the highest impact.
    CONCLUSIONS: During the pandemic, scientific publications on dentistry and COVID-19 have been increasing considerably. International collaboration has the highest percentage of publications whilst India and the UK are the countries with the highest scientific production.
    Keywords:  COVID-19; Scholarly output; Scientometrics
    DOI:  https://doi.org/10.1016/j.identj.2022.04.007
  20. Med Sci Monit. 2022 May 18. 28 e936327
      BACKGROUND Electrical impedance tomography (EIT) is a new test that has been widely used by clinicians in recent years at bedside or in ICU wards. Studies and publications on EIT increased quickly and the hotspot trends changed; however, the overview and characteristics of such studies have not yet been reported. Therefore, we have attempted to interpret the evolution of EIT and to anticipate its possible future clinical use by conducting a statistical analysis of EIT articles over the past 20 years. MATERIAL AND METHODS We analyzed EIT-related articles from 2020 and the 20 years prior, sourced from the Web of Science database. The data collected included the number of articles published, the classification of the articles, basic information, and author affiliation. RESULTS Our study retrieved a total of 1427 EIT-related articles through screening, with the most articles published from Chinese authors and the Chinese Air Force Military Medical University, and the most cited article type being EIT-related basic research. Most articles on EIT have been published in the journal Physiological Measurement. Furthermore, the hotspots and research trends of EIT have changed from basic innovation development to clinical application in the past 20 years. CONCLUSIONS This paper presents a statistical analysis of articles on EIT over the last 20 years, focusing on trends from the mechanisms of EIT to its clinical use.
    DOI:  https://doi.org/10.12659/MSM.936327
  21. Sleep Breath. 2022 May 17.
       OBJECTIVES: The purpose of this study was to systematically analyze the studies of hypertension associated with obstructive sleep apnea to assess the current status and hot spots in this field.
    METHODS: We searched the Web of Science Core Collection for publications related to hypertension associated with obstructive sleep apnea published before July 3, 2021. Bibliometric analyses and science mappings were carried out using the CiteSpace 5.8.R1 and Microsoft Office Excel 2019. CiteSpace 5.8.R1 was used to visualize the distribution of research fields, analyze co-occurring keywords and burst terms to detect trends and frontiers, and identify leading collaborations among countries, authors, and institutions. Microsoft Office Excel 2019 was used to make bar graphs, histograms and line graphs.
    RESULTS: According to the search strategy, a total of 7263 published articles and reviews were retrieved. The research on hypertension associated with obstructive sleep apnea has been developing quickly at present. Sleep and Breathing was the most productive journal. The USA was a major producing country and Harvard Medical School was the most productive institution in this field. In the field of hypertension associated with obstructive sleep apnea, the main research hotspots were continuous positive airway pressure, cardiovascular disease, and obesity.
    CONCLUSIONS: The present study provides a new perspective for the study of hypertension associated with obstructive sleep apnea and valuable information for researchers to find potential partners and cooperative institutions, hot issues and research frontiers.
    Keywords:  Bibliometric analysis; Hotspots; Hypertension; Obstructive Sleep apnea
    DOI:  https://doi.org/10.1007/s11325-022-02637-8
  22. Eur J Ophthalmol. 2022 May 16. 11206721221101360
       PURPOSE: To identify global research trends in teleophthalmology, as well as productivity and its association with Human development index (HDI).
    METHODS: A cross-sectional study. The main outcome measures were publication count, citation count, and publications count per million populations. Bibliographic data were derived from the Web of Science website. HDI data were derived from Human Development Report [2020]. One-way ANOVA test was used to examine the association between HDI and the outcome measures. We studied the correlation between continuous variables using Spearman's. Bibliometric analysis software's VOSviewer and Citspace were used to analyse results and creating visualizing maps.
    RESULTS: The results retrieved 355 publications, one-third of them have been published in the year of the COVID-19 pandemic; (2020). The USA has contributed to one-half of all publications, and just five countries have contributed to about 90% of all records. Very high HDI countries had significantly more publications count per million populations, than high (p-value = 0.0047), medium (p-value = 0.0081) or low HDI countries (p-value = 0.002). The main themes are screening programmes, reliability, photography, COVID-19, access, artificial intelligence, and cost-effectiveness. The leading countries in terms of both publications and citation count are the USA and India. In terms of publications count per million populations, the leading countries are Singapore and Australia.
    CONCLUSION: Most of the contribution in teleophthalmology research was confined to a small number of countries. More effort is needed to expand the global contribution. The hotspots in this field are artificial intelligence applications and COVID-19 impact.
    Keywords:  Practice management; legal aspects of medical/surgical therapy; preventive medicine/screening; retinal pathology/research; telemedicine
    DOI:  https://doi.org/10.1177/11206721221101360
  23. J Foot Ankle Res. 2022 May 20. 15(1): 39
       OBJECTIVES: Temporal and global changes in research utilising imaging to assess foot osteoarthritis is currently unknown. This study aimed to undertake a bibliometric analysis of published research to: (1) identify the imaging modalities that have been used to evaluate foot osteoarthritis; (2) explore the temporal changes and global differences in the use of these imaging modalities; and (3) to evaluate performance related to publication- and citation-based metrics.
    METHODS: A literature search was conducted using Scopus to identify studies which had used imaging to assess foot osteoarthritis. Extracted data included publication year, imaging modality, citations, affiliations, and author collaboration networks. Temporal trends in the use of each imaging modality were analysed. Performance analysis and science mapping were used to analyse citations and collaboration networks.
    RESULTS: 158 studies were identified between 1980 and 2021. Plain radiography was the most widely used modality, followed by computed tomography, magnetic resonance imaging (MRI) and ultrasound imaging (USI), respectively. The number of published studies increased over time for each imaging modality (all P ≥ 0.018). The most productive country was the United States of America (USA), followed by the United Kingdom and Australia. International authorship collaboration was evident in 57 (36.1%) studies. The average citation rate was 23.4 per study, with an average annual citation rate of 2.1.
    CONCLUSIONS: Published research employing imaging to assess foot osteoarthritis has increased substantially over the past four decades. Although plain radiography remains the gold standard modality, the emergence of MRI and USI in the past two decades continues to advance knowledge and progress research in this field.
    Keywords:  Foot osteoarthritis; Imaging modalities
    DOI:  https://doi.org/10.1186/s13047-022-00549-0
  24. Cent European J Urol. 2022 ;75(1): 102-109
       Introduction: The COVID-19 pandemic has caused wide-reaching change to many aspects of life on a worldwide scale. The impact of these changes on peer-reviewed research journals, including those dedicated to urology, is still unknown.
    Material and methods: The Web of Science database was queried to retrieve all COVID-19 urological articles written in English language and published between January 1st, 2020 and December 10th, 2021. Only original and review articles were considered. A bibliometric analysis of the total number of papers, citations, institutions and publishing journals was performed. Non-COVID-19 publications were also retrieved to compare the duration of publication stages.
    Results: A total of 428 COVID-19 articles and 14,874 non-COVID-19 articles were collected. Significant differences in the duration of all the publication stages were found between COVID-19 and non-COVID-19 articles (all p <0.001). The most productive countries were the USA (100 articles), Italy (59 articles) and the United Kingdom (55 articles). The published literature has focused on four topics: COVID-19 genitourinary manifestations, management of urological diseases during the pandemic, repercussions on quality of life and impact on healthcare providers.
    Conclusions: A significant reduction in peer review time for COVID-19 articles might raise concerns regarding the quality of peer review itself. USA, Italy and UK published the highest number of COVID-19 related articles. Restrictive measures taken by governments to reduce the spread of infection had a strong impact on mental stress and anxiety of patients and healthcare professionals. A coerced deferral of diagnosis and treatment of emergencies and uro-oncological cases represented the most challenging task from a clinical standpoint.
    Keywords:  COVID-19; bibliometric analysis; coronavirus; trends; urology
    DOI:  https://doi.org/10.5173/ceju.2021.291
  25. Regen Med. 2022 May 17.
      The primary goal of this study was to compile the top 50 most cited articles on the use of platelet-rich plasma (PRP). A search of relevant studies was performed in accordance with the PRISMA guidelines in Web of Science. The top 25 most cited articles in osteoarthritis and tendinopathy were then compiled and evaluated. Level 1 evidence articles constituted the majority of the studies (64%) and were more likely to have a higher citation density. Altmetric data was highest for level 1 systematic reviews. Of the articles that report a positive outcome for PRP, 13% (2/16) had low risk of bias. This study defines the most cited and influential publications regarding PRP to further research in this area.
    Keywords:  PRP; growth factors; osteoarthritis; platelet-rich plasma; regeneration; repair; sports medicine; tendinopathy
    DOI:  https://doi.org/10.2217/rme-2022-0024
  26. North Clin Istanb. 2022 ;9(2): 188-196
      A large amount of scientific literature is forcing those who want to study the subject deeply. In general, the number of articles available exceeds thousands. It has become challenging both to dominate the current concept and to see the relationships between the developments that feed the concept. Visualization techniques based on bibliometric data help to gain an overview of the literature on complex research topics. The aim of this study is to examine the topic of "patient safety" with a bibliometric analysis program. The data of 8372 articles obtained from the Web of Science database were analyzed with SciMAT2 software. Before the analysis, general findings regarding the raw data were brought to the fore. The strategic diagram and thematic development map have been analyzed in terms of 10-year periods covering the past 30 years. Five motor themes ("contrast agent," "adverse events," "program," "safety," "prostatectomy") were identified in 1990-1999, four motor themes ("infection control," "hospital-acquired infections," "adverse drug events," "culture") in 2000-2009 and nine motor themes ("patient safety," "education," "climate," "system," "mortality," "operating room," "validity," "burnout," "primary care") in 2010-2019. The number of motor themes increased during the period and adverse events, which were the active subjects of the early periods, were replaced by new concepts (such as climate, primary care, and burnout) over time. Bibliometric visualization tools make it possible to analyze the literature consisting of a large number of articles. This approach facilitates a person''s understanding of a complex research topic such as patient safety and ensures that they are aware of new research directions or alternative research priorities.
    Keywords:  Bibliometric analysis; SciMAT, thematic development; patient safety; science mapping
    DOI:  https://doi.org/10.14744/nci.2021.87847
  27. Psychiatry Res. 2022 May 10. pii: S0165-1781(22)00222-0. [Epub ahead of print]313 114621
      Women authors are under-represented in academic medicine and academic publishing. We examined the representation of women in key authorship positions in psychiatric journals in India as well as time trends in female authorship across a decade. All articles originating from India and published in two leading Indian psychiatry journals during 2019-2020 were examined and compared with articles published in these journals during 2009-2010. Important outcomes examined were representations of women as first author, corresponding author, and last author, and the number of women in authorship lists. A total of 817 articles was analyzed; of these, 251 (30.7%) were published during 2009-2010 and 566 (69.3%) during 2019-2020. Women first-authored just over a quarter of the articles (n = 218, 26.7%). Nearly half of the articles (n = 389, 47.6%) had no woman author. Representation of women in key authorship positions and in total authorship increased significantly across time. Notably, the proportion of women first authors significantly increased for original papers (24.5% in 2009-2010 vs 38.1% in 2019-2020, p = 0.011). Gender gap in academic psychiatry publishing in India has narrowed during the past decade but is still evident. There is a need to identify and address factors that could narrow the gender gap.
    Keywords:  Aacademia; Ggender bias; Ggender equality; Lleadership; Ppsychiatry; Wwomen in medicine
    DOI:  https://doi.org/10.1016/j.psychres.2022.114621
  28. Transl Cancer Res. 2022 Apr;11(4): 772-783
       Background: CD38 is a transmembrane glycoprotein that is relatively highly expressed on multiple myeloma (MM) cells, and CD38-targeting antibodies use pleiotropic mechanisms to kill MM cells. Immunotherapy, with an increased quality of response and acceptable toxicity, shows tremendous potential for treating MM. This research field study aimed to analyze all the relevant literature via bibliometrics to identify its course of development and structural relationships.
    Methods: A total of 1,030 relevant articles were retrieved from the Web of Science Core Collection (WoSCC) from 1985 to June 21, 2021. CiteSpace was employed to map authors/references/countries with nodes and links, extract highly cited keywords, analyze the time trends of keywords, recognize cocited authors/references, set timezone or timeline views, analyze burstness and generate a dual map. VOSviewer was used to recognize connections among journals and construct collaboration networks. bibliometric.com was utilized to trace advanced countries/regions in the research field.
    Results: All of the articles were cited 24,332 times in total, with an average of 23.62 times. Most articles were published in the United States of America (USA), far outweighing other countries/regions. The current hotspots in this field are related to the following keywords: "monoclonal antibody", "refractory MM", "idecabtagene vicleucel", and "B cell maturation antigen (BCMA)". Ten significant clusters, namely, "flow cytometry", "daratumumab", "BCMA", "cell line", "antitumor activity", "gene", "non-Hodgkin's lymphoma", "peripheral blood", "survival" and "anti-CD38", were extracted. The mechanism and effectiveness of CD38-targeting antibodies in treating MM have been studied. Future research hotspots will focus on new therapies for relapsed and refractory multiple myeloma (RRMM) patients.
    Conclusions: In the past, efforts were applied to elucidate the mechanism and effectiveness of CD38-targeting antibodies in treating MM. Future research hotspots will focus on anti-BCMA chimeric antigen receptor T cell (CAR-T) immunotherapy for patients with RRMM. According to this article, new researchers can discover its course of development and structural relationships in this field.
    Keywords:  CD38-targeting antibody; CiteSpace; Multiple myeloma; VOSviewer; bibliometric analysis; daratumumab; immunotherapy
    DOI:  https://doi.org/10.21037/tcr-21-1962
  29. Environ Sci Pollut Res Int. 2022 May 19.
      In order to reduce environmental degradation, there has been an increased focus on identifying the main conftributors to environmental degradation and reducing carbon footprints to promote sustainable development. Although the recent focus on institutional and policy reforms has led to a higher focus on environmental discussion, little is known about the status of research on the Pollution Haven Hypothesis (PHH). Hence, the current study evaluates the research dynamics of this field by recognizing most central researchers and key publication outlets from the perspectives of most citations and productivity, research directions, common keywords, countries with the highest academic contribution, and changes in research matrices. Our selection of 494 journal articles from the WOS indicates that King Saud University and the University of Wah were the most productive research institutions, and China was the most productive geographical region. Environmental Science & Pollution Research was identified as the most common outlet for research publications. We also identified strong academic cooperation, notably between China and Pakistan. Moreover, the co-occurrence network identified the Pollution Haven Hypothesis and economic growth nexus, trade, pollution haven and developing economies and FDI, carbon emissions, and pollution haven nexus as the three main prevailing research themes. Lastly, we provide useful policy implications to maximize the impact of environmental reforms and avoid environmental degradation.
    Keywords:  Bibliometric analysis; Climate change; Environmental degradation; Foreign direct investment; Pollution Haven Hypothesis
    DOI:  https://doi.org/10.1007/s11356-022-20782-1
  30. Environ Sci Pollut Res Int. 2022 May 19.
      Climate-smart agriculture (CSA) is a new agricultural development pattern to address future food crises. Since CSA was proposed in 2010, it has attracted the attention of scholars from all over the world. It is of great significance to scientifically summarize the overview and emerging trends of CSA research, providing ideas for scholars concerned about CSA to engage in research in this field. Based on bibliometrics and CSA-related literature data in the WOS database, this paper used CiteSpace software to draw knowledge maps to scientifically analyze publications in the field of CSA. Our study found that (1) CSA research is showing a rapid upward trend, focusing on the environmental sciences and agricultural economic management; (2) international organizations such as the FAO, World Bank, and the international agricultural research institute have made significant contributions to CSA research; (3) among the nine clusters in the CSA literature, CSA practice, conservation agriculture, smallholder farmers, and sub-Saharan Africa have been consistently given high attention; (4) CSA research can be divided into three phases, and the research hotspots have transferred from essential elements of CSA to household and carbon emissions. We believe that in future research, more attention should be paid to the trade-off and synergy of the three pillars of CSA, as well as the investment, finance, and evaluation criteria of CSA. Such strengthening is of great significance to the sustainable promotion of CSA.
    Keywords:  Bibliometric analysis; CiteSpace; Climate-smart agriculture; Food security; Knowledge map
    DOI:  https://doi.org/10.1007/s11356-022-20796-9
  31. Front Psychiatry. 2022 ;13 853296
      The study of clinical high risk for psychosis (CHR-P) has progressed rapidly over the last decades and has developed into a significant branch of schizophrenia research. Organizing the information about this rapidly growing subject through bibliometric analysis enables us to gain a better understanding of current research trends and future directions to be pursued. Electronic searches from January 1991 to December 2020 yielded 5,601 studies, and included 1,637 original articles. After processing the data, we were able to determine that this field has grown significantly in a short period of time. It has been confirmed that researchers, institutions, and countries are collaborating closely to conduct research; moreover, these networks are becoming increasingly complex over time. Additionally, there was a shift over time in the focus of the research subject from the prodrome, recognition, prevention, diagnosis to cognition, neuroimaging, neurotransmitters, cannabis, and stigma. We should aim for collaborative studies in which various countries participate, thus covering a wider range of races and cultures than would be covered by only a few countries.
    Keywords:  bibliometric analysis; clinical high risk for psychosis; collaborative study; research network; research trends; schizophrenia
    DOI:  https://doi.org/10.3389/fpsyt.2022.853296
  32. J Gambl Stud. 2022 May 19.
      Gambling as a risk factor in youth development, particularly its causes and consequences, has been the subject of a growing number of studies. However, the literature relating to young people has yet to be compiled in a systematic form. The present study adopts a descriptive bibliometric approach to map global research on gambling in young people using metadata from the Web of Science database. The results show that research on gambling in young people at a country level has increased in recent years, though some regions are underrepresented. Co-occurrence analysis revealed the frequent use of several terms. It is hoped that these findings will assist in future research on the subject.
    Keywords:  Bibliometric method; Co-occurrence analysis; Gambling; Young people
    DOI:  https://doi.org/10.1007/s10899-022-10131-9
  33. Front Public Health. 2022 ;10 855633
      COVID-19, which occurred at the end of December 2019, has evolved into a global public health threat and affects every aspect of human life. COVID-19's high infectivity and mortality prompted governments and the scientific community to respond quickly to the pandemic outbreak. The application of personal protective equipment (PPE) is of great significance in overcoming the epidemic situation. Since the discovery of severe acute respiratory coronavirus 2 (SARS-CoV-2), bibliometric analysis has been widely used in many aspects of the COVID-19 epidemic. Although there are many reported studies about PPE and COVID-19, there is no study on the bibliometric analysis of these studies. The citation can be used as an indicator of the scientific influence of an article in its field. The aim of this study was to track the research trends and latest hotspots of COVID-19 in PPE by means of bibliometrics and visualization maps.
    Keywords:  COVID-19; VOSviewer; bibliometric; personal protective equipment; transmission
    DOI:  https://doi.org/10.3389/fpubh.2022.855633
  34. Med Sci Monit. 2022 May 15. 28 e936037
      BACKGROUND The microbiome-gut-brain axis (MGBA) is the biochemical signal of the digestive tract and central nervous system. MGBA disorders have been increasingly involved in the pathological process of neurological diseases. This study aimed to investigate the research hot spots of MGBA from 2004 to 2020. MATERIAL AND METHODS Using bibliometric analysis from the Web of Science Core Collection (WOSCC) database, 3993 documents on the MGBA were retrieved and visual analysis was conducted. RESULTS The MGBA has received attention worldwide and will continue to be a research hot spot. Emerging research organizations and scholars of the MGBA and the research of John F. Cryan and colleagues from Ireland in the MGBA have been recognized by many scholars. However, the research of Chinese scholars and organizations appeared to have less impact due to lack of research innovation and collaboration with other countries/regions. Keyword analysis showed that neuroinflammation was a hot spot and that eminent scholars had begun to work in the field of MGBA. CONCLUSIONS This work provided an overall view of the literature on the MGBA worldwide, and the analysis provided a comprehensive overview of MGBA research. It further revealed the interaction between the gut microbiota (eg, Akkermansia, Parabacteroides) and the specific regulatory network of the gut microbiota and metabolites, neuroinflammation, and neural networks, which can facilitate the development of effective treatment strategies using microbiota for targeting neuroinflammation and conducting large-scale clinical trials of neurological diseases.
    DOI:  https://doi.org/10.12659/MSM.936037
  35. JMIR Form Res. 2022 May 18. 6(5): e31292
       BACKGROUND: Due to scientific and technical advancements in the field, published hypertension research has developed substantially during the last decade. Given the amount of scientific material published in this field, identifying the relevant information is difficult. We used topic modeling, which is a strong approach for extracting useful information from enormous amounts of unstructured text.
    OBJECTIVE: This study aims to use a machine learning algorithm to uncover hidden topics and subtopics from 100 years of peer-reviewed hypertension publications and identify temporal trends.
    METHODS: The titles and abstracts of hypertension papers indexed in PubMed were examined. We used the latent Dirichlet allocation model to select 20 primary subjects and then ran a trend analysis to see how popular they were over time.
    RESULTS: We gathered 581,750 hypertension-related research articles from 1900 to 2018 and divided them into 20 topics. These topics were broadly categorized as preclinical, epidemiology, complications, and therapy studies. Topic 2 (evidence review) and topic 19 (major cardiovascular events) are the key (hot topics). Most of the cardiopulmonary disease subtopics show little variation over time, and only make a small contribution in terms of proportions. The majority of the articles (414,206/581,750; 71.2%) had a negative valency, followed by positive (119, 841/581,750; 20.6%) and neutral valency (47,704/581,750; 8.2%). Between 1980 and 2000, negative sentiment articles fell somewhat, while positive and neutral sentiment articles climbed substantially.
    CONCLUSIONS: The number of publications has been increasing exponentially over the period. Most of the uncovered topics can be grouped into four categories (ie, preclinical, epidemiology, complications, and treatment-related studies).
    Keywords:  LDA; cardiovascular; high blood pressure; hypertension; latent Dirichlet allocation; machine learning; research trends; topic modeling
    DOI:  https://doi.org/10.2196/31292
  36. IEEE Access. 2022 ;10 33281-33300
      COVID-19 has dramatically affected various aspects of human society with worldwide repercussions. Firstly, a serious public health issue has been generated, resulting in millions of deaths. Also, the global economy, social coexistence, psychological status, mental health, and the human-environment relationship/dynamics have been seriously affected. Indeed, abrupt changes in our daily lives have been enforced, starting with a mandatory quarantine and the application of biosafety measures. Due to the magnitude of these effects, research efforts from different fields were rapidly concentrated around the current pandemic to mitigate its impact. Among these fields, Artificial Intelligence (AI) and Deep Learning (DL) have supported many research papers to help combat COVID-19. The present work addresses a bibliometric analysis of this scholarly production during 2020. Specifically, we analyse quantitative and qualitative indicators that give us insights into the factors that have allowed papers to reach a significant impact on traditional metrics and alternative ones registered in social networks, digital mainstream media, and public policy documents. In this regard, we study the correlations between these different metrics and attributes. Finally, we analyze how the last DL advances have been exploited in the context of the COVID-19 situation.
    Keywords:  Bibliometric analysis; COVID-19; deep learning; scholarly production
    DOI:  https://doi.org/10.1109/ACCESS.2022.3159025
  37. Front Cardiovasc Med. 2022 ;9 890329
      The aim of this study was to gain insight into the progress and dynamics of psycho-cardiological disease research and track its hot spots. We have analyzed psycho-cardiological disease-related literature extracted from the Web of Science (WOS) Core Collection from 2001 to 2021 with the help of Cite Space. As a result, we have included 5,032 records. Then, we have analyzed connected networks for the country, author, subject category, keywords, and cited reference. We have summarized the findings in four aspects. First, the annual quantitative distribution of publications is on the rise, although there is a slight drop. Second, in terms of country analysis, the United States, England, Australia, Germany, and Italy are the main research forces in psycho-cardiological diseases. At the same time, several academic entities represented by Andrew Steptoe and Roland von Känel, MD, have been formed based on the early consciousness of physical and mental health in these countries. Besides, China is also more concerned about it due to the rapid population aging process and the largest population. Third, the psycho-cardiological disease is multidisciplinary, including psychology, psychiatry, clinical medicine, such as cardiovascular system and neurology, public environmental and occupational health, and pharmacology. Finally, the results of keyword analysis and co-cited references indicate the hot spots and frontiers in psycho-cardiological disease. The hot spots in psycho-cardiological disease include three aspects. The first aspect includes psychosocial factors, such as depression, lack of social support, and low economic and social status; the second aspect includes priority populations, such as Alzheimer's disease dementia caregivers, elderly, and patients with cancer, and the third aspect includes interventions, such as exercise therapy and diet. In addition, there are three future research frontiers. The first is a psycho-cardiological disease in patients with COVID-19; the second is cardiac rehabilitation, especially exercise therapy and health behavior evaluation; and the final is evidence-based medical evaluation, such as systematic reviews and meta-analyses.
    Keywords:  bibliometric analysis; cardiovascular diseases; cite space software; mapping knowledge domains; psycho-cardiological disease
    DOI:  https://doi.org/10.3389/fcvm.2022.890329
  38. PLoS One. 2022 ;17(5): e0268433
      The trend of the number of publications on a research field is often used to quantify research interest and effort, but this measure is biased by general publication record inflation. This study introduces a novel metric as an unbiased and quantitative tool for trend analysis and bibliometrics. The metric was used to reanalyze reported publication trends and perform in-depth trend analyses on patent groups and a broad range of field in the life-sciences. The analyses confirmed that inflation bias frequently results in the incorrect identification of field-specific increased growth. It was shown that the metric enables a more detailed, quantitative and robust trend analysis of peer reviewed publications and patents. Some examples of the metric's uses are quantifying inflation-corrected growth in research regarding microplastics (51% ± 10%) between 2012 and 2018 and detecting inflation-corrected growth increase for transcriptomics and metabolomics compared to genomics and proteomics (Tukey post hoc p<0.0001). The developed trend-analysis tool removes inflation bias from bibliometric trend analyses. The metric improves evidence-driven decision-making regarding research effort investment and funding allocation.
    DOI:  https://doi.org/10.1371/journal.pone.0268433
  39. Environ Sci Pollut Res Int. 2022 May 16.
      In recent years, the research of SMEs' eco-innovation (EI) has gained attention on an international scale. However, only a few studies provide a global research panorama. This study attempts to bridge this knowledge gap by utilizing the scientometric tools. A total of 749 articles from ISI web of science core collection were collected and analyzed to generate the result, which demonstrated a wealth of useful new conclusions in this domain. The results show that (i) the research topics on SMEs' EI are changing dynamically and become more diversified from 1997 to 2021, especially from 2014 to 2021. (ii) The newest research frontiers are logically consistent with the previous knowledge base, while reflect the novelty of the research, which shows more correlation and adaptation to the newest development situation. (iii) The innovation paradigm in this field has not yet formed, and correlational studies are still in the early stage and a paradigm of open innovation is strongly recommended for researchers. And the barriers, category, process, outcome, and more similar subdivided themes of SMEs' EI are worthy to be further explored. For research methods, inter-regional, inter-institutional, and interdisciplinary perspectives are hopeful to contribute to future research avenues. Some useful inspirations are also provided for practitioners to develop SMEs' EI.
    Keywords:  Diversified trends; Eco-innovation; Scientometric analysis; Small and medium-sized enterprises
    DOI:  https://doi.org/10.1007/s11356-022-20657-5
  40. Plast Surg (Oakv). 2022 May;30(2): 159-163
       Background: Physicians with history of unprofessional behaviour during their medical training are shown to be 3 times more likely to have board disciplinary action later in their career. One realm in which unprofessional behaviour takes place is the phenomenon of unverifiable publications or "ghost publications." To that end, this study aims to assess the rate of ghost publications among a recent cohort of Canadian Plastic Surgery residency applicants to determine if this phenomenon is geographic in nature.
    Methods: The current study was a retrospective, cross-sectional observational study; a review of all residency applications submitted to a single Canadian Plastic Surgery residency program from 2015 to 2018 was performed and all their listed publications were verified for accuracy. The review was conducted by a third party librarian and a research coordinator blinded to the authors identifying information. "Ghost publication" was defined as any publication listed as "published," "accepted," or "in-press" that did not exist in the literature.
    Results: A total of 196 applications of 186 applicants were submitted over the span of 4 years. A total of 362 publications listed as peer-reviewed articles, belonging to 114 applications were extracted and reviewed. Among the 362 publications listed as peer-reviewed articles, 2 could not be found in the literature (0.55%). Additionally, 42 citations were found with 48 minor differences than what was cited.
    Conclusions: The rate of ghost publications among recent applicants to a Plastic Surgery residency program is low (less than 1%). Future studies should investigate methods to further improve and instill the value of professionalism in our future plastic surgery trainees.
    Keywords:  application; plastic surgery; residency; resident
    DOI:  https://doi.org/10.1177/22925503211003843
  41. Langenbecks Arch Surg. 2022 May 18.
       PURPOSE: The International Abstract(s) of Surgery (IAS) was a monthly supplement to Surgery, Gynecology & Obstetrics (SG&O, later Journal of the American College of Surgeons) from 1913-1994, approximately equal in size to the journal itself. It followed the example of the Zentralblatt für Chirurgie (ZblCh), which had been compiling abstracts of the current world surgical literature since 1874 (but in the German language). This article seeks to review the relationships of these surgical abstract journals in historical context.
    METHODS: Citations in the IAS were systematically sampled for 1913-1990, and in the ZblCh and other American and German surgical publications for 1905-1940. Changes in the proportions of citations by language category were tabulated over time and related to concurrent international events and the publication histories of the sampled journals.
    RESULTS: German-language citations were most frequent until the First World War, even in America. They subsequently became less frequent in America, but remained dominant in Germany. Articles in French or other languages were occasionally cited by Americans, but in German publications, they were cited as frequently as those in English. Contemporary observations from this time confirm that the American literature was being disregarded by most German surgeons. Since the Second World War, surgical publications have become predominantly English-language, even in Germany, and printed abstract compilations have become irrelevant.
    CONCLUSIONS: The history of the IAS and ZblCh reflects world events of the early twentieth century, the isolation and decline of German scientific leadership, the rise of American surgery, and the transition from a multilingual print-based era to one where scientific communication is primarily electronic and in English.
    Keywords:  Abstract journals; American College of Surgeons; Deutsche Gesellschaft für Chirurgie; International Abstracts of Surgery; Zentralblatt für Chirurgie
    DOI:  https://doi.org/10.1007/s00423-022-02538-0
  42. Cell Prolif. 2022 May 17. e13239
       OBJECTIVES: The rapid development of cerebral organoid technology and the gradual maturity of cerebral organoids highlight the necessity of foresighted research on relevant ethical concerns. We employed knowledge graphs and conducted statistical analysis with CiteSpace for a comprehensive analysis of the status quo of the research on the ethical concerns of cerebral organoids from a bibliometric perspective.
    MATERIALS AND METHODS: We performed a statistical analysis of published papers on cerebral organoid ethics, keyword co-occurrence graph, literature co-citation and knowledge clustering graph to examine the status of the ethics research, internal relationship between technological development and ethical research, and ethical concerns of the academia. Finally, we used a keyword time zone graph and related statistics to analyze and predict the trends and popular topics of future cerebral organoids ethics research.
    RESULTS: We demonstrated that although the ethical concerns of cerebral organoids have long been discussed, it was not until 2017 that the ethical issues began to receive more attention, when cerebral organoids were gradually mimicking the human brain more closely and increasingly being combined with chimera research. The recent key ethical concerns are primarily divided into three categories: concerns that are common in life sciences, specific to cerebral organoids, and present in cross-fields. These increasing ethical concerns are inherently related to the continual development of technology. The analysis pointed out that future research should focus on the ethical concerns of consciousness that are unique to cerebral organoids, ethical concerns of cross-fields, and construction and improvement of legislative and regulatory systems.
    CONCLUSIONS: Although research on cerebral organoids can benefit the biomedicine field, the relevant ethical concerns are significant and have received increasing attention, which are inherently related to the continual development of technology. Future studies in ethics regarding cerebral organoid research should focus on the ethical concerns of consciousness, and cross-fields, as well as the improvement of regulatory systems.
    DOI:  https://doi.org/10.1111/cpr.13239
  43. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2022 Mar;34(3): 294-300
       OBJECTIVE: To investigate the static and dynamic trends of scientific research efficiency of the critical care medicine in hospitals affiliated S university during the 13th Five-Year Plan period.
    METHODS: Based on the scientific research data of 16 hospitals affiliated to Beijing S University from 2014 to 2020, the scientific research investment funds and the number of physicians involved in scientific research were selected as input evaluation indexes, and the number of science citation index (SCI) papers, Chinese science citation database (CSCD) papers, and the number of masters and doctors trained were selected as output evaluation indexes, and the evaluation index system of scientific research efficiency of critical care medicine was constructed. SPSS version 23.0 software was used for descriptive data statistics, and data envelopment analysis (DEA)-BCC model and DEA-Malmquist index model of DEAP 2.1 software were used for static and dynamic evaluation of its scientific research efficiency from 2016 to 2020, respectively.
    RESULTS: (1) The scientific research technical efficiency (TE) of critical care medicine in 16 hospitals affiliated with S universities varied greatly from 2016 to 2020, but pure technical efficiency (PTE) and scale efficiency (SE) were at a good level, and 6-11 affiliated hospitals in critical care medicine kept DEA effective for 5 consecutive years. (2) Dynamic analysis of their total factor productivity (TFP) of scientific research from 2016 to 2020 showed a trend of rising and then falling and then rising again. The mean value was 0.985. The technical efficiency change (TEC) showed a decreasing and then increasing trend, and the technical progress change (TC) showed a slow increasing and then decreasing trend, with a mean value of 0.953. While the mean values of TEC, pure technical efficiency change (PTEC) and scale efficiency change (SEC) were above 1, which showed that the growth of total factor productivity index of research and innovation depended more on the technical efficiency index.
    CONCLUSIONS: The "gain effect" and "catch-up effect" of scientific research efficiency in the specialty of critical care medicine in hospitals affiliated S universities are obvious, but the "growth effect" is not obvious. "Although the research efficiency of the 13th Five-Year Plan period has been significantly improved, there is still much room for improvement in scientific and technological innovation and international academic influence.
    DOI:  https://doi.org/10.3760/cma.j.cn121430-20220112-00050
  44. Chemosphere. 2022 May 17. pii: S0045-6535(22)01483-7. [Epub ahead of print] 134990
      Massive prevalence of microplastics (MPs) in the environment has become one of the world's most serious environmental concerns. Human dependence on plastics has created a constant flow of MPs from different sources into natural environment, which has raised public concern regarding consequences of MPs coming into contact with the natural environment. Deploying constructed wetlands (CWs) to reduce MPs pollution is considered a promising method, however there are still barriers for breakthroughs in this technology, particularly knowledge gaps in the mechanisms affect removal process. Recognising this, we provide a comprehensive summary of current advances and theories regarding the mechanisms of occurrence in this research area. In this work, the bibliometric methods were first used to identify annual publication trends and topical topics of research interest. The selected documents were then statistically analyzed using VOSviewer and the 'bibliometrix' package in R to derive the annual productivity of countries or organizations, the most relevant affiliations, the most relevant authors, the most relevant sources, textual analysis, co-occurrence analysis, and cluster analysis of keywords. Finally, detailed information concerning the removal of MPs by CWs was summarised, covering the most common operational and design parameters (i.e., structure types, wetland plants, substrate materials, and microbial communities), to reveal how these parameters can be adjusted for more efficient MPs removal rate. Challenges and future directions were additionally proposed. It is hoped that the review will help identify current research trends, provide insight into the mechanisms of the removal process, and contribute further to the development of this important area.
    Keywords:  Constructed wetlands; Microplastics; Nanoplastics; Removal efficiency; Scientific bibliometric analysis
    DOI:  https://doi.org/10.1016/j.chemosphere.2022.134990
  45. Ann Am Thorac Soc. 2022 May 19.
       RATIONALE: The COVID-19 pandemic has negatively affected women more than men and may influence the publication of non-COVID research.
    OBJECTIVES: Evaluate whether the COVID-19 pandemic is associated with changes in manuscript acceptance rates among pulmonary/critical care journals, and gender-based disparities in these rates.
    METHODS: We analyzed first, senior, and corresponding-author gender (female vs. male, identified by matching first names in a validated Genderize database) of manuscripts submitted to four pulmonary/critical care journals between 1/1/18-12/31/20. We constructed interrupted time series regression models to evaluate whether the proportion of female first and senior authors of non-COVID-19 original research manuscripts changed with the pandemic. Next, we performed multivariable logistic regressions to evaluate the association of author gender with acceptance of original research manuscripts.
    RESULTS: Among 8,332 original research submissions, women comprised 39.9% and 28.3% of first and senior authors, respectively. We found no change in the proportion of female first or senior-authors of non-COVID-19 or COVID-19-submitted research manuscripts during the COVID-era. Non-COVID-19 manuscripts submitted during the COVID-era had reduced odds of acceptance, regardless of author gender (first-author: adjustedOR [aOR]0.46 [95%CI0.36-0.59]; senior-author: aOR0.46 [95%CI0.37-0.57]). Female senior-authorship was associated with decreased acceptance of non-COVID research manuscripts (crude rates: 14.4% [male] vs 13.2% [female]; aOR0.84, 95%CI0.71-0.99).
    CONCLUSIONS: Although female author submissions were not disproportionately influenced by COVID-19, we found evidence suggesting gender disparities in manuscript acceptance rates. Journals may need to consider strategies to reduce this disparity and academic institutions may need to factor our findings, including lower acceptance rates for non-COVID manuscripts, into promotion decisions.
    DOI:  https://doi.org/10.1513/AnnalsATS.202203-277OC
  46. Science. 2022 May 20. 376(6595): 782-783
      Researchers who pivoted from distant disciplines produced lower impact work, study finds.
    DOI:  https://doi.org/10.1126/science.add0532
  47. Plast Surg (Oakv). 2022 May;30(2): 144-150
       Background: Predatory journals promise high acceptance rates and quick publication in exchange for a processing fee. As these journals aim to maximize profits, they neglect traditional mechanisms used to ensure a high-quality publication. Unsolicited email invitations are a characteristic of predatory journals that often inundate the inboxes of surgeons. The objective of this study is to use these emails to identify potentially predatory journals in the area of surgery and plastic surgery.
    Methods: Unsolicited email requests from surgery-related journals were collected over a 3-month period. Journals were evaluated using a modified version of the Rohrich and Weinstein checklist. The average number of "predatory" criteria met by these potentially predatory journals (PPJs) was compared to that of the top open-access plastic surgery journals which were assumed to be non-predatory for the purposes of this study.
    Results: In total, 437 unsolicited email requests were received. Of these, 92 emails, representing 57 PPJs, were eligible for inclusion. On average, the PPJs met 5 of the 12 "predatory" criteria, compared to less than 1 in the comparison group. Approximately 96% of these emails, or the respective websites, contained obvious spelling or grammatical mistakes; 98% of these emails came from journals not listed on Scopus, Directory of Open Access Journals (DOAJ), and/or Web of Science.
    Conclusions: Of the journals that sent unsolicited emails, 98% met 2 or more criteria and were deemed to be predatory. If a journal contains grammatical mistakes and is not listed on Scopus, DOAJ, and/or Web of Science, authors should be cautious.
    Keywords:  open-access journals; plastic surgery; predatory journals; publications; surgery
    DOI:  https://doi.org/10.1177/22925503211002456
  48. Sensors (Basel). 2022 Apr 22. pii: 3238. [Epub ahead of print]22(9):
      The imbalance of oxidation and antioxidant systems in the biological system can lead to oxidative stress, which is closely related to the pathogenesis of many diseases. Substances with antioxidant capacity can effectively resist the harmful damage of oxidative stress. How to measure the antioxidant capacity of antioxidants has essential application value in medicine and food. Techniques such as DPPH radical scavenging have been developed to measure antioxidant capacity. However, these traditional analytical techniques take time and require large instruments. It is a more convenient method to evaluate the antioxidant capacity of antioxidants based on their electrochemical oxidation and reduction behaviors. This review summarizes the evaluation of antioxidants using electrochemical sensors by bibliometrics. The development of this topic was described, and the research priorities at different stages were discussed. The topic was investigated in 1999 and became popular after 2010 and has remained popular ever since. A total of 758 papers were published during this period. In the early stages, electrochemical techniques were used only as quantitative techniques and other analytical techniques. Subsequently, cyclic voltammetry was used to directly study the electrochemical behavior of different antioxidants and evaluate antioxidant capacity. With methodological innovations and assistance from materials science, advanced electrochemical sensors have been fabricated to serve this purpose. In this review, we also cluster the keywords to analyze different investigation directions under the topic. Through co-citation of papers, important papers were analyzed as were how they have influenced the topic. In addition, the author's country distribution and category distribution were also interpreted in detail. In the end, we also proposed perspectives for the future development of this topic.
    Keywords:  antioxidant; electrochemical sensor; flavonoid; plant extract; polyphenols
    DOI:  https://doi.org/10.3390/s22093238