bims-evares Biomed News
on Evaluation of research
Issue of 2022–04–10
38 papers selected by
Thomas Krichel, Open Library Society



  1. Heliyon. 2022 Mar;8(3): e09173
      This paper reviews the pertinent literature from 1970 to 2020 and presents a bibliometric analysis of research trends in the application of solid-state fermentation in the bioprocessing of agro-industrial wastes. A total 5630 publications of studies on solid-state fermentation that comprised of 5208 articles (92.50%), 340 book chapters (6.04%), 39 preprints (0.69%), 32 proceedings (0.56%), 8 edited books (0.14%) and 3 monographs (0.05%) were retrieved from Dimensions database. A review of the literature indicated that (i) fermentation of solid substrates is variously defined in the literature over the past 50 years, where "solid-state fermentation" is the most dominant research term used, and (ii) key products derived from the valorization of agro-industrial wastes through solid-state fermentation include, among others, enzymes, antioxidants, animal feed, biofuel, organic acids, biosurfactants, etc. Bibliometric analyses with VOSviewer revealed an astronomic increase in publications between 2000 and 2020, and further elucidated the most frequently explored core research topics, the most highly cited publications and authors, and countries/regions with the highest number of citations. The most cited publication between 2010 and 2020 had 382 citations compared to 725 citations for the most cited publication from 1970 to 2020. Ashok Pandey from India was the most published and cited author with 123 publications and 8,613 citations respectively; whereas Bioresource Technology was the most published and cited journal with 233 publications and 12,394 citations. Countries with the most publications and citations are Brazil, France, India, and Mexico. These findings suggest that research in the application of solid-state fermentation for bioprocessing of agro-industrial wastes has gained prominence over the past 50 years. Future perspectives and implications are discussed.
    Keywords:  Agro-industrial residues; Bibliometrics; Bioprocessing; Microbial biotechnology; Solid-state fermentation; Valorization
    DOI:  https://doi.org/10.1016/j.heliyon.2022.e09173
  2. Front Psychol. 2022 ;13 828390
       Background: Problem-Based Learning (PBL) is an instructional method of hands-on, active learning centered on investigating and resolving messy, real-world problems. This study aims to systematically analyze the current status and hotspots of PBL research and provide insights for research in the field.
    Methods: Problem-based learning-related publications were retrieved from the Web of Science Core Collection using "Problem-Based Learning". Annual publications, countries, institutions, authors, journals, references, and keywords in the field were visually analyzed using the R, VOSviewer, and Microsoft Excel 2019 software.
    Results: A total of 2,790 articles and reviews were analyzed, with a steady increase in publications in the field of PBL. Overall, the United States was the major contributor to the study of PBL. Van Der Vleuten CPM was the key researcher in this field. Moreover, most of the publications were published in Medical Education. Keyword analysis showed that current research hotspots focus on the extensions of PBL teaching mode, application of PBL teaching method, and reform of PBL.
    Conclusion: Research on PBL is flourishing. Cooperation and exchange between countries and institutions should be strengthened in the future. These findings will provide a better understanding of the state of PBL research and inform future research ideas.
    Keywords:  bibliometric analysis; citation; education; problem-based learning; research
    DOI:  https://doi.org/10.3389/fpsyg.2022.828390
  3. J Pain Res. 2022 ;15 837-856
       Background: In recent years, the research on subacromial impingement syndrome (SIS) has gradually increased. Although the research directions are diverse, the overall research status and trend are not clear.
    Objective: The aim of our study was to use bibliometric analysis to identify the trends in SIS-related research and to analyze the most highly cited scientific publications on SIS.
    Methods: All data were retrieved from the Web of Science Core Collection database, and the year of publications, countries, journals, institutions and total number of citations were extracted and analyzed. The results related to countries, institutions and keywords were then analyzed using VOSviewer software and bibliometrics online analysis platform. And, we also identified the 100 most cited articles on SIS.
    Results: A total of 548 articles related to AIS were identified. The frequency of publication on SIS has increased substantially over time. Among all countries, Turkey has contributed the most publications on SIS (n=118). The institution with the most articles was Istanbul University (n=17). Journal of Shoulder and Elbow Surgery topped the list of journals and has published 19 SIS-related publications. The hotspot of research changed from the former arthroscopic surgery to physical therapy and rehabilitation.
    Conclusion: The scientific research on SIS has rapidly expanded in recent years. This study represents the first bibliometric analysis of SIS, gives us a systematic and comprehensive summary into the development of SIS.
    Keywords:  SIS; VOSviewer; Web of Science; bibliometric analysis; research trends; subacromial impingement syndrome
    DOI:  https://doi.org/10.2147/JPR.S348528
  4. Mymensingh Med J. 2022 Apr;31(2): 569-579
      The aim of the study was to identify and analyze the top 50 influential articles showing historical developments and current research activity published during January 1979 - December 2019 in the European Review for Medical and Pharmacological Sciences journal. Electronic search was conducted using Scopus database to retrieve publications in the journal of European Review for Medical and Pharmacological Sciences journal during January 1979 - December 2019. The papers ranked in ascending order with citation count ≥47. Furthermore frequent first and co-authors; number of funding sources reported; study type and authors affiliated institute and country of origin was identified in these highly cited articles. Of the highly cited studies published, qualitative and quantitative studies were published in predominance (n=47) trailed by reviews studies (n=6). All the top 50 cited articles were contributed by single nations without any collaborations (n=53). The universities contributing major amount of top cited articles included Nanjing Medical University and Sapienza University of Rome (n=7) respectively, followed by Capital Medical University (n=3). China was the nation majorly contributed for top cited articles. The use of pharmacological therapies for different medical conditions published in European Review for Medical and Pharmacological Sciences journal during the last 40 years were extensively explored and reported.
  5. Clin Exp Med. 2022 Apr 07.
      The bibliometric analysis uses the citation count of an article to measure its impact in the scientific community, but no study has been undertaken to determine the most influential papers in the field of primary biliary cholangitis (PBC). This study aimed to investigate the global research interest regarding PBC in dentistry using a bibliometric approach. We searched the Web of Science Core Collection database to find the top 100 most cited (T100) articles focusing on PBC. The information about each article including citations, authors, journals, countries, institutions, and keywords was recorded for bibliometric analysis. The T100 articles related to PBC were published from 1983 to 2019 and were originated from 26 countries. A total of 805 different authors were from 342 different institutions, and articles written by them were published in 35 journals. The five most frequently occurring keywords were "biochemical response," "ursodeoxycholic acid," "primary biliary cirrhosis," "antimitochondrial antibody," and "autoimmunity." The T100 articles were classified into different research focuses: pathogenesis (41%), treatment (20%), prognosis (12%), epidemiology (9%), diagnosis (8%), and others (10%). These 100 articles included 32 observational studies, 29 basic research articles, 15 reviews, eight meta-analyses, 12 clinical trials, and four clinical guidelines. The 100 top-cited articles are marked with the leading countries, institutions, journals, hotspots, and development trends in the PBC field that could provide the foundation for further investigations.
    Keywords:  Bibliometric; Citation analysis; Primary biliary cholangitis; Primary biliary cirrhosis
    DOI:  https://doi.org/10.1007/s10238-022-00825-0
  6. Front Med (Lausanne). 2022 ;9 846480
       Background: Pulmonary alveolar proteinosis (PAP) is a rare syndrome first described by Rosen et al. in 1958. Despite our considerably evolved understanding of PAP over the past decades, no bibliometric studies have been reported on this field. We aimed to analyze and visualize the research hotspots and current trends of the PAP research field using a bibliometric analysis to help understand the future development of basic and clinical research.
    Methods: The literature regarding PAP was culled from the Web of Science Core Collection (WoSCC) database. Data were extracted from the relevant articles and visually analyzed using CiteSpace and VOSviewer software.
    Results: Nine hundred and nine qualifying articles were included in the analysis. Publications regarding PAP increased over time. These articles mainly come from 407 institutions of 57 countries. The leading countries were the USA and Japan. University of Cincinnati (USA) and Niigata University (Japan) featured the highest number of publications among all institutions. Bruce C Trapnell exerts a significant publication impact and has made the most outstanding contributions in the field of PAP. American Journal of Physiology-Lung Cellular and Molecular Physiology was the journal with the most publications, and American Journal of Respiratory and Critical Care Medicine was the most commonly cited journal. All the top 5 co-cited journals belong to Q1. Keyword citation bursts revealed that inflammation, deficiency, tissue resident macrophage, classification, autoimmune pulmonary alveolar proteinosis, sarcoidosis, gm csf, high resolution ct, and fetal monocyte were the emerging research hotspots.
    Conclusion: Research on PAP is prosperous. International cooperation is also expected to deepen and strengthen in the future. Our results indicated that the etiology and pathogenesis of PAP, current and emerging therapies, especially the novel pathogenesis-based options will remain research hotspots in the future.
    Keywords:  CiteSpace; VOSviewer; alveolar macrophage; autoimmune pulmonary alveolar proteinosis (aPAP); bibliometric analysis; granulocyte-macrophage colony-stimulating factor (GM-CSF); pulmonary alveolar proteinosis (PAP)
    DOI:  https://doi.org/10.3389/fmed.2022.846480
  7. Environ Sci Pollut Res Int. 2022 Apr 06.
      Several countries across the African continent have been challenged with energy crises for decades. A growing number of studies have identified renewable energy as a sustainable way for Africa to address its persisting energy situation while combating climate change, as the continent has in abundance some of the common renewable energy resources. Little has been reported in the body of literature to quantitatively and qualitatively map the knowledge domain of this growing research field. In the current study, we conduct a bibliometric analysis on research documents extracted from the Web of Science Core Collection to identify trends and characteristics of the knowledge domain related to renewable energy in Africa from 1999 to 2021. Using two different software (VOSviewer and ITgInsight), we report the contribution of journals, countries, institutions, and authors and their collaboration patterns. We also perform co-citation and keyword analysis to identify the intellectual base and central themes of this research field. The results from the study revealed a growing interest in Africa's renewable energy, with about 90% of the total publication from within the last decade. Renewable & Sustainable Energy Reviews was identified as the most productive as well as the most influential journal in this field. The most contributing countries in this field were South Africa, USA, and Algeria. Centre de Developpement Des Energies Renouvelables, a research institute in Algeria, emerged as the most productive and influential institution. The analysis of research hotspots under different categories revealed that "solar energy," "CO2 emissions," and "rural electrification" are the topics that have gained maximum attention over the years. Keyword evolution analysis also identified "economic growth" and "green hydrogen production" as emerging topics that will play a major role in future studies. We conclude our work by providing specific suggestions and strategies to help bridge the gap which exists in the quantity and quality of renewable energy research between Africa and the rest of the world.
    Keywords:  Africa; Bibliometric analysis; Electricity; Renewable energy; Research trend
    DOI:  https://doi.org/10.1007/s11356-022-20125-0
  8. Noncoding RNA Res. 2022 Jun;7(2): 77-88
       Background and purpose: Circular RNAs (circRNAs) are a big group of members of the noncoding RNA family following long non-coding RNA and microRNA. They play a regulatory role in many biological processes. Analyzing their current research status and future development trends is conducive to a more comprehensive understanding of circRNAs and contributes to the dedication to the biological field.
    Methods: The literature on circRNA from 2000 to 2021 in the Web of Science Core Collection of the Web of Science database with "circular RNA" as the subject was searched. R Studio's Bibliometrix package and biblioshiny software were used for publication trend analysis, citation analysis, keyword analysis, author analysis, research institution analysis, source analysis, country analysis, and collaboration analysis for all documents and highly cited documents.
    Results: From 2000 to 2021, 3,186 circRNA-related articles were published worldwide, of which 193 were highly cited. The number of published articles had shown an explosive increase after 2013. These articles were mainly from Chinese research institutions and authors, but the country with the highest average number of citations per year in highly cited documents was Germany. Scientific research institutions came from countries represented by Germany, USA, China, Australia and Canada all had different degrees of cooperation. The theme and key points of the research had evolved over time from expression to the role and mechanism of circRNA in diseases, especially in cancer. CDR1as, circFOXO3, circHIPK3, circITCH, circMTO1, circSMARCA5 and circZNF609 are circRNAs that are mainly studied currently, their studies mainly involve cell biology, biological functions and cancer. The future research direction and trend would still be the application of circRNA in diseases.
    Conclusion: The basic situation and development trend of circRNA related research we described provide a direction for future research.
    Keywords:  Bibliometric analysis; Biblioshiny; CDR1as, antisense to the cerebellar degeneration-related protein 1 transcript; FOXO3, forkhead box O3; HIPK3, homeodomain interacting protein kinase 3; ITCH, itchy E3 ubiquitin protein ligase; MTO1, mitochondrial tRNA translation optimization 1; SMARCA5, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5; USA, The United States of America; ZNF609, zinc finger protein 609; circRNA; circRNA, circular RNA
    DOI:  https://doi.org/10.1016/j.ncrna.2022.03.001
  9. Climacteric. 2022 Apr 04. 1-7
       OBJECTIVE: This study aimed to carry out a bibliometric analysis of primary ovarian insufficiency (POI) from 2010 to 2020 and to reveal the research status and hotspots in the future.
    METHOD: A total of 3087 articles and reviews related to POI published from 2010 to 2020 retrieved from the Web of Science Core Collection were used for bibliometric analysis. CiteSpace and VOSviewer were adopted to analyze countries and regions, organizations, authors, journals, keywords and co-cited references.
    RESULTS: The number of publications about POI increased year by year. The USA produced the largest number of publications and the most influence in this field. The main research directions of POI can be roughly divided into four aspects according to the analysis of keywords and co-cited references: genetic research of POI; stem cell therapy for patients with POI; prediction of ovarian function; and fertility preservation of cancer patients. Genetic research and stem cell therapy may become research hotspots in the future.
    CONCLUSION: This study might be the first bibliometric study to analyze publications of POI from multiple indicators, in order to provide new opinions for the research trends and possible hotspots of POI.
    Keywords:  Bibliometric analysis; CiteSpace; VOSviewer; premature ovarian failure; primary ovarian insufficiency
    DOI:  https://doi.org/10.1080/13697137.2022.2052841
  10. Future Oncol. 2022 Apr 05.
      Background: N6-methyladenosine (m6A) is crucial in cancer and is being intensively studied. Aim: This bibliometric analysis seeks a broad picture of the role of m6A in cancer to guide and broaden future research. Methods: Publications were retrieved from Web of Science Core Collection and PubMed from 2000 to 2021, with keywords 'm6A' and 'cancer', and analyzed in biblioshiny and VOSviewer. Results: A total of 1013 documents were included, and China and the USA were the top countries with close collaboration. Mechanisms and predictive biomarkers of m6A regulator genes were highlighted. Cross-integration of m6A and other research hot spots, including 'immunotherapy', 'hypoxia' and 'polymorphism', were frontiers of m6A in cancer. Conclusion: This bibliometric study offered an updated perspective on m6A in cancer.
    Keywords:  N6-methyladenosine; bibliometric analysis; cancer; epigenetic transcriptomics; m6A
    DOI:  https://doi.org/10.2217/fon-2022-0086
  11. Front Immunol. 2022 ;13 840956
       Objectives: A bibliometric and knowledge-map analysis is used to explore hotspots' evolution and development trends in the CAR-T cell field. By looking for research hotspots and new topics, we can provide new clues and ideas for researchers in this field.
    Methods: The articles and reviews regarding CAR-T cells were retrieved and obtained from the Web of Science Core Collection (WOSCC) on October 28th, 2021. CtieSpace [version 5.8.R3 (64-bit)] and VOSviewer (version 1.6.17) were used to conduct the bibliometric and knowledge-map analysis.
    Results: 660 authors from 488 institutions in 104 countries/regions published 6,867 papers in 1,212 academic journals. The United States was absolutely in the leading position in this research field. The institution that contributed the most publications was the University of Pennsylvania. Carl H June published the most articles, while Shannon L Maude had the most co-citations. However, there was little cooperation between countries. After 2012, cooperation among various institutions was also small. The journals that published the most CAR-T cell-related papers were Frontiers in immunology and Cancers. Nevertheless, Blood and The New England Journal of Medicine were the most commonly co-cited journals. The most influential research hotspots were the research of CAR-T cells in hematological malignancies, the related research of cytokine release syndrome (CRS), CD19, and the anti-tumor activity and efficacy of CAR-T cells. The latest hotspots and topics included the study of CAR-T cells in solid tumors, universal CAR-T cells, CAR-NK cells, CD22, and anakinra (the IL-1 receptor antagonist). The research of CAR-T cells in solid tumors was a rapidly developing hot field. Emerging topics in this field mainly included the study of CAR-T cells in glioblastoma (related targets: IL13Rα2, EGFRvIII, and HER2), neuroblastoma (related target: GD2), sarcoma (related target: HER2), and pancreatic cancer (related target: mesothelin), especially glioblastoma.
    Conclusion: As an anti-tumor therapy with great potential and clinical application prospects, CAR-T cell therapy is still in a stage of rapid development. The related field of CAR-T cells will remain a research hotspot in the future.
    Keywords:  CAR-T cell; Citespace; VOSviewer; bibliometric; hotspots; knowledge-map; topics
    DOI:  https://doi.org/10.3389/fimmu.2022.840956
  12. Foot Ankle Orthop. 2022 Jan;7(1): 24730114221088490
       Background: Despite significant effort expended toward exploring fracture patterns, surgical timing, surgical approaches, and possible implants within the calcaneus fracture literature, treatment is still fraught with complications and controversy. This study aims to conduct a citation analysis of the most cited articles related to calcaneus fractures to highlight the most historically influential articles, as well as the more recent breakthrough articles that are leading change within the field.
    Methods: A literature search was performed via Scopus on September 20, 2021 using the terms "(calcaneus OR calcaneal OR hindfoot) AND (fracture OR injury)" to search "article title, abstract, and keywords" of all primary and review articles. Search results were rigorously reviewed to ensure appropriateness for this study. The 50 highest total cited included articles were analyzed. Title, authors, journal, country of origin, institution, year of publication, citation variables (total citation count, total citation density, citation count from the last 5 years, and 5-year citation density), and level of evidence were collected for each article. One-way analysis of variance with post hoc testing was used to identify differences in citation variables and level of evidence. Pearson correlation was used to directly compare different citation variables.
    Results: The total citation count average was 178±33, with a total citation density average of 9±2. The year of publication for the 50 articles ranged from 1948 to 2014, with a median year of 1999. Roy W. Sanders was the most productive author in the field, authoring 6 articles and lead authoring 3. The most frequent level of evidence was IV with 19 articles. There was a strong correlation between total citation density and 5-year citation density. The article level of evidence showed no impact on the included measures of an article's influence.
    Conclusion: This study successfully analyzes and presents the characteristics among the highest cited articles related to calcaneus fractures. The provided characterization of influential works and authors highlights trends, impactful findings, and future areas of focus within calcaneus fracture literature.Level of Evidence: Review Article.
    Keywords:  calcaneus fracture; citation analysis; citation count; citation density
    DOI:  https://doi.org/10.1177/24730114221088490
  13. Curr Probl Cardiol. 2022 Apr 05. pii: S0146-2806(22)00091-3. [Epub ahead of print] 101194
       BACKGROUND: Patients with type 2 diabetes (T2DM) are more likely to have cardiovascular disease (CVD). Glucose-lowering drugs with cardiovascular benefits represented by Glucagon-like peptide 1 receptor agonists (GLP1RAs) were discovered and gained more and more attention.
    METHODS: Data from 1985 to the 2021 were downloaded in the Web of Science Core Collection (WoSCC) database. CiteSpaceV was used for bibliometric analysis to find research hotspots and frontiers.
    RESULTS: The 2088 papers were published by 74 countries (regions), 876 institutions, and 2203 authors. The annual publications increased over time from 2005 to 2020. DIABETES OBESITY METABOLISM published the most papers. The USA and China were the top 2 productive nations. The leading institution was the University of Copenhagen, and the most productive researcher was John B Buse. The most cited paper is "Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes" (by Marso SP, 2016). The research hotspots include the effects of GLP1RA on cardiovascular outcomes, efficacy, complicated metabolic abnormalities, protective mechanisms, and other novel anti-diabetic drugs for cardiovascular protection. Research frontiers include cardiovascular studies on semaglutide, as well as the most prominent research approach in the field-placebo-controlled trial.
    CONCLUSION: Numerous countries, institutions, and authors have focused on GLP1RA in cardiovascular research and a great deal of literature has been published. Five research hotspots and two frontiers illustrate the current status and emerging trends of GLP1RA in cardiovascular research. The cardiovascular effects and clinical efficacy of GLP1RA are a current hot topic that is rapidly evolving and of high research value.
    Keywords:  bibliometric analysis; cardiovascular disease; cardiovascular outcome; glucagon-like peptide 1 receptor agonists; type 2 diabetes mellitus
    DOI:  https://doi.org/10.1016/j.cpcardiol.2022.101194
  14. Pathophysiology. 2022 Feb 25. 29(1): 66-80
      miRNAs biomarkers are emerging as an essential part of clinical oncology. Their oncogenic and tumour suppressor properties playing a role in malignancy has generated interest in their potential for use in disease prognosis. While several studies on miRNA have been carried out across the globe, evaluating the clinical implications of miRNAs in cancer diagnosis and prognosis research has currently not been attempted. A study delineating the area of miRNA research, including the topics presently being focused on, the seminal papers in this field, and the direction of research interest, does not exist. This study aims to conduct a large-scale, global data analysis and bibliometric profiling analysis of studies to evaluate the research output of clinical implications of miRNAs in cancer diagnosis and prognosis listed in the SCOPUS database. A systematic search strategy was followed to identify and extract all relevant studies, subsequently analysed to generate a bibliometric map. SPSS software (version 27) was used to calculate bibliometric indicators or parameters for analysis, such as year and country of affiliation with leading authors, journals, and institutions. It is also used to analyse annual research outputs, including total citations and the number of times it has been cited with productive nations and H-index. The number of global research articles retrieved for miRNA-Cancer research over the study period 2003 to 2019 was 18,636. Between 2012 and 2019, the growth rate of global publications is six times (n = 15,959; 90.71 percent articles) that of 2003 to 2011. (2704; 9.29 per cent articles). China published the most publications in the field of miRNA in cancer (n = 7782; 41%), while the United States had the most citations (n = 327,538; 48%) during the time span. Of these journals, Oncotarget has the highest percentage of article publications. The journal Cancer Research had the most citations (n = 41,876), with 6.20 per cent (n = 41,876). This study revealed a wide variety of journals in which miRNA-Cancer research are published; these bibliometric parameters exhibit crucial clinical information on performance assessment of research productivity and quality of research output. Therefore, this study provides a helpful reference for clinical oncologists, cancer scientists, policy decision-makers and clinical data researchers.
    Keywords:  bibliometric analysis; cancer; clinical diagnostics; clinical prognostics; miRNA
    DOI:  https://doi.org/10.3390/pathophysiology29010007
  15. Hosp Top. 2022 Apr 05. 1-7
      The dataset was generated from Scopus database for the study due to its compatibility with bibliometrix R package. The dataset shows that there is a gradual increase in publication of research articles on digital health and mobile health till 2016 before a sudden rise in number of publications from 2017 onwards. This paper contributes by providing a consolidation of fragmented literature in the research domain giving us information on significant sources, authors and documents. The analysis of conceptual structure reveals that the topics of study have evolved from mobile health to digital health, e-health, technology acceptance model, privacy, implementation and self-management.
    Keywords:  Digital health; bibliometric analysis; bibliometrix R; m-health; mobile health
    DOI:  https://doi.org/10.1080/00185868.2022.2060155
  16. Environ Sci Pollut Res Int. 2022 Apr 06.
      The climate change effect has received a crucial concern from global policymakers as well as academic researchers. The climate change effect is a real-world issue threatening the existence of species and human beings, thus causing the economic vulnerability. Apart from policymakers, academic researchers are showing their concern on the effect of climate change on economic and socioeconomic vulnerability through publishing research articles in the recent decade. In light of the revolution of research articles, this study applied a bibliometric analysis on the academic research articles to explore the publication trends, themes, impacts, and potential scopes for further studies. Both the Scopus and the Web of Science online databases were used to search for journal articles linked to climate change effects and economic vulnerability. The final data of 229 journal articles were analyzed using bibliometric and visualization tools "Biblioshiny" and "VOSViewer." The findings unveiled an uprising trend in publications and posited several themes, mainly exposure, sensitivity, drought, and flood by means of climate change effects that affect economic vulnerability. Based on the findings and review of literature, several research gaps were identified and offered opportunities for further studies. The policymakers can attribute attention to encouraging more research in several areas in addition to agriculture and coastal regions.
    Keywords:  Bibliometric analysis; Climate change; Economic vulnerability; Socioeconomic vulnerability
    DOI:  https://doi.org/10.1007/s11356-022-20028-0
  17. Front Pharmacol. 2022 ;13 862585
      Methods: Articles on inflammatory tumor microenvironment were retrieved from the Web of Science Core Collection, and the characteristics of the articles were analyzed by CiteSpace software. Background: The inflammatory tumor microenvironment is an essential feature of the tumor microenvironment. The way in which it promotes or inhibits tumor progression plays an important role in the outcome of a tumor treatment. This research aims to explore a scientific collaboration network, describe evolution of hotspots, and predict future trends through bibliometric analysis. Results: A total of 3,534 papers published by 390 institutions in 81 countries/regions were screened, and the annual quantity has been increasing rapidly in the past decades. United States was the leading country and has the most productive institutions in this field. The research topics were mainly focused on inflammation and immunity mediated by crucial factors as well as the mechanisms of angiogenesis. Additionally, the development and application of nanoparticles is currently a novel research frontier with bright prospect. Conclusion: The present scientometric study provides an overview of inflammatory tumor microenvironment research over the previous decades using quantitative and qualitative methods, and the findings of this study can provide references for researchers focusing on tumor treatment.
    Keywords:  CiteSpace; bibliometric; hotspot; inflammatory tumor microenvironment; visualization
    DOI:  https://doi.org/10.3389/fphar.2022.862585
  18. Transl Pediatr. 2022 Mar;11(3): 411-422
       Background and Objective: This review examines a promising new framework for analyzing outputs of pediatric research in the context of translational advancement. We demonstrate a method for evaluating the impact of an NIH Clinical and Translational Science Award's (CTSA) Pediatrics Program through publications that have emerged from supported research. The Georgia CTSA Pediatrics Program provides training, funding, and infrastructure to ensure that researchers have the resources to advance pediatric health. Internal evaluations found that research supported by this program is exceptionally impactful within the academic community and commands high interest within the lay community. Therefore, we examined the impact of this research in both traditional academic and broader community spheres using bibliometrics-the study of supported publications. Bibliometrics describe a pivotal stage in the translational process of bringing scientific discoveries to clinical/community use and include both academic citations and 'altmetric' or non-academic attention. These complementary approaches combine to shed light on the short- and long-term impact of the research on segments of the translational pipeline, including academic literature, community discourse, technological advancement, and public health policy.
    Methods: The authors identified a portfolio of 250 articles supported by the Georgia CTSA Pediatrics Program from 2007-2020. We utilized various bibliometrics to analyze both short-term attention, or 'splash' made by articles, and long-term influence, or 'ripples' made across both academic and public spheres.
    Key Content and Findings: The short-term splash of the portfolio was indicated through publication in high-impact factor journals, peer faculty recommendations, and Mendeley readership, as well as by early altmetric attention in news stories, blogs, and Twitter posts. The portfolio's long-term ripples were demonstrated by high absolute and relative rates of academic citation and by downstream altmetric influence in public-facing documents, including Wikipedia articles, patent applications, and policy documents.
    Conclusions: This article reviews a useful bibliometric methodology for illustrating the waves of impact made by pediatric research. Whereas splash provides a picture of early interest in a publication, a preliminary indicator of eventual utility and impact, ripples provide a measure of the cumulative influence of an article over time. Both reflect opportunities for a line of research to advance along the translational spectrum.
    Keywords:  Bibliometrics; Clinical and Translational Science Award (CTSA); altmetrics; pediatric
    DOI:  https://doi.org/10.21037/tp-21-506
  19. Front Med (Lausanne). 2022 ;9 842919
      Chronic kidney disease (CKD) is a growing global health challenge with an increasing incidence rate. Exercise-based renal rehabilitation is an evidence-based, multidisciplinary, and comprehensive intervention designed to improve the physical and psychological condition of patients with CKD. The knowledge structure, research hotspots, and development trends in exercise-based renal rehabilitation have not been systematically described. The aim of this study was to provide a bibliometric perspective of the progress in this field. Publications about exercise-based renal rehabilitation were retrieved from the Web of Science Core Collection, using the terms "exercise," "physical activity," and "chronic kidney disease." Annual publications, subject categories, countries, authors, references, and keywords in this field were visually analyzed using the Citespace, VOSview, and Excel software. A total of 4,610 publications were analyzed, with a steady increase in publications in the field. Overall, the United States is the major contributor to the study of exercise-based renal rehabilitation. Johansen KL and Painter P are the key researchers in this field. Keyword analysis shows that research hotspots in this field include exercise/physical activity for different stages of CKD, exercise-based renal rehabilitation for frailty, and physical activity management for CKD. These findings will make understanding exercise-based renal rehabilitation research better and inform about future research ideas.
    Keywords:  Citespace; VOSview; bibliometric analysis; chronic kidney disease; exercise-based renal rehabilitation
    DOI:  https://doi.org/10.3389/fmed.2022.842919
  20. JAAD Int. 2022 Mar 30.
      
    Keywords:  COVID-19; authorship; bibliometric; citations; cutaneous manifestations; infectious disease; medical literature
    DOI:  https://doi.org/10.1016/j.jdin.2022.03.012
  21. Environ Sci Pollut Res Int. 2022 Apr 04.
      With the acceleration of urbanization and industrialization, carbon neutrality and peak carbon dioxide emissions have become common sustainability goals worldwide. However, there are few literature statistics and econometric analyses targeting carbon neutrality and peak carbon dioxide emissions, especially the publication trends, geographic distribution, citation literature, and research hotspots. To conduct an in-depth analysis of existing research fields and future perspectives in this research area, 1615 publications from the Web of Science Core Collection, between 2010 and 2020, were evaluated by using three analysis tools, under the framework of the bibliometrics method. These publications are distributed between the start-up (2010-2015) and the stable development (2016-2020) phases. Cluster analysis suggests three areas of ongoing research: energy-related carbon emissions, methane emissions, and energy biomass. Overall, future trends in this field include cumulative carbon emissions, the residential building sector, methane emission measurement, nitrogen fertilization, land degradation neutrality, and sciamachy satellite methane measurement. Finally, this paper further examines the most comprehensive coverage of nitrogen fertilization and the most recent research of the residential building sector. In view of the statistical clusters from 1615 publications, this paper provides new insights and perspectives for climate-environment-related researchers and policymakers. Specifically, countries could apply nitrogen fertilizer to crops according to the conditions of different regions. Additionally, experiences from developed countries could be learned from, including optimizing the energy supply structure of buildings and increasing the use of clean energy to reduce CO2 emissions from buildings.
    Keywords:  Bibliometric analysis; Carbon neutrality; Global evaluation; Low-carbon economy; Peak carbon dioxide emissions; Sustainable development
    DOI:  https://doi.org/10.1007/s11356-022-19764-0
  22. Environ Sci Pollut Res Int. 2022 Apr 04.
      Sustainable development emergent subfields have been rapidly evolving, and their popularity increased in recent years. Sustainable development is a broad concept having numerous sub-concepts including, but not limited to, circular economy, sustainability, renewable energy, green supply chain, reverse logistics, and waste management. This polymorphism makes decision-making in this field to be an abstruse task. In this perplexing circumstance, the presence of VUCA conditions makes decision-making even more challenging. By taking advantage of artificial intelligence tools and approaches, this paper aims to study with a concentration on sustainable development-related decision-making under VUCA phenomena elements using bibliometric and network analyses which can propose numerous novel insights into the most recent research trends in this area by analyzing the most influential and cited research articles, keywords, author collaboration network, institutions, and countries that finally provides results not previously fully comprehended or assessed by other studies on this topic. In this study, an extensive systematic literature review and bibliometric analysis are conducted using 534 research articles out of more than 3600. From the content analysis part, four clusters have been found. The decision parameters, presumptions, and research goal(s) for each model are pointed out too. The findings contribute to both conceptual and practical managerial aspects and provide a powerful roadmap for future research directions in this field, such as how real-life multidimensionality can be considered in sustainable development-related decision-making, or what are the effects of the VUCA in sustainable development considering the circular economy and waste management intersection.
    Keywords:  Artificial intelligence; Bibliometrics; Decision-making; Sustainability; Sustainable development; Systematic literature review; VUCA
    DOI:  https://doi.org/10.1007/s11356-022-19863-y
  23. PLoS One. 2022 ;17(4): e0265381
      Article-level measures of publication impact (alternative metrics or altmetrics) can help authors and other stakeholders assess engagement with their research and the success of their communication efforts. The wide variety of altmetrics can make interpretation and comparative assessment difficult; available summary tools are either narrowly focused or do not reflect the differing values of metrics from a stakeholder perspective. We created the EMPIRE (EMpirical Publication Impact and Reach Evaluation) Index, a value-based, multi-component metric framework for medical publications. Metric weighting and grouping were informed by a statistical analysis of 2891 Phase III clinical trial publications and by a panel of stakeholders who provided value assessments. The EMPIRE Index comprises three component scores (social, scholarly, and societal impact), each incorporating related altmetrics indicating a different aspect of engagement with the publication. These are averaged to provide a total impact score and benchmarked so that a score of 100 equals the mean scores of Phase III clinical trial publications in the New England Journal of Medicine (NEJM) in 2016. Predictor metrics are defined to estimate likely long-term impact. The social impact component correlated strongly with the Altmetric Attention Score and the scholarly impact component correlated modestly with CiteScore, with the societal impact component providing unique insights. Analysis of fresh metrics collected 1 year after the initial dataset, including an independent sample, showed that scholarly and societal impact scores continued to increase, whereas social impact scores did not. Analysis of NEJM 'notable articles' showed that observational studies had the highest total impact and component scores, except for societal impact, for which surgical studies had the highest score. The EMPIRE Index provides a richer assessment of publication value than standalone traditional and alternative metrics and may enable medical researchers to assess the impact of publications easily and to understand what characterizes impactful research.
    DOI:  https://doi.org/10.1371/journal.pone.0265381
  24. Scientometrics. 2022 Mar 25. 1-22
      From a network perspective, this study analyzes 659 users mentioning sampled COVID-19 articles 10 or more times on Twitter with a focus on their roles in facilitating the process of scholarly communication. Different from existing studies, we consider both the user types and the automation of accounts to profile influential users in the network of research dissemination. Our study found that similar to academic users, non-academic users can also be active players in communicating scientific publications. The results highlight the intensive interactions between human users and automated accounts, including bots and cyborgs, which accounted for 45% of connections among the top users. This study also demonstrates the important role of automated accounts in initiating and facilitating research dissemination. Specifically, (1) bot-assisted academic publishers showed the highest amplifier scores, which measures a user's tendency of being the first to share information and reach out to others within their trusted networks, (2) 5.28% of the selected articles was first tweeted by automated research feeds, ranking the fourth among the 22 classified user groups, and (3) bot-assisted publishers and automated feeds of generic topics and news alerts were highly ranked in authority, a network measure to quantify the degree to which a user consumes important resources of relevant topics. In the conclusion section, we discuss future directions to improve the validity of Twitter metrics in assessing research impacts.
    Keywords:  Altmetrics; Bot; Network analysis; Scholarly communication; Twitter
    DOI:  https://doi.org/10.1007/s11192-022-04343-4
  25. PLoS One. 2022 ;17(4): e0266439
      The gender gap in computer science (CS) research is a well-studied problem, with an estimated ratio of 15%-30% women researchers. However, far less is known about gender representation in specific fields within CS. Here, we investigate the gender gap in one large field, computer systems. To this end, we collected data from 72 leading peer-reviewed CS conferences, totalling 6,949 accepted papers and 19,829 unique authors (2,946 women, 16,307 men, the rest unknown). We combined these data with external demographic and bibliometric data to evaluate the ratio of women authors and the factors that might affect this ratio. Our main findings are that women represent only about 10% of systems researchers, and that this ratio is not associated with various conference factors such as size, prestige, double-blind reviewing, and inclusivity policies. Author research experience also does not significantly affect this ratio, although author country and work sector do. The 10% ratio of women authors is significantly lower than the 16% in the rest of CS. Our findings suggest that focusing on inclusivity policies alone cannot address this large gap. Increasing women's participation in systems research will require addressing the systemic causes of their exclusion, which are even more pronounced in systems than in the rest of CS.
    DOI:  https://doi.org/10.1371/journal.pone.0266439
  26. Heliyon. 2022 Apr;8(4): e09220
      Solar Thermal is one of many heat sources that support the organic Rankine cycle (ORC) system. The advantage of using solar thermal as a heat source when combined with the ORC system is that it can provide affordable energy supplies in remote areas and it is suitable in disaster territories. Growth in solar-ORC research is not only on a lab/workshop scale but also on an industrial scale. Most articles refer to methods and tools in the design process, combining heat and improvement of the cycle, working fluids selection, and case studies based on primary or secondary data. The paper reports the newest trends on the research of solar application on ORC using bibliometric analysis. The study of bibliometric using VOSviewer was recognized as a captivating method in the literature that allows examining the scientific progress of a particular topic. Moreover, a qualitative approach can be performed by analyzing the keywords contained in different documents to identify a circumstance that features the research trend and to understand future viewpoints.
    Keywords:  Improvement the cycle; Qualitative approach; Solar thermal; VOSviewer
    DOI:  https://doi.org/10.1016/j.heliyon.2022.e09220
  27. J Ophthalmol. 2022 ;2022 3539134
       Purpose: To describe the evolution of COVID-19 related publications in the field of ophthalmology.
    Methods: All articles published in the field of ophthalmology and relevant to COVID-19 were identified by conducting a search on PubMed and Scopus databases using the string ((ophthalmology) OR (eye) OR (ocular)) AND ((corona) OR (COVID-19) OR (pandemic)). Search was conducted on September 30, 2020. Each eligible publication was independently graded by two experienced ophthalmologists based on the level of evidence-based medicine (EBM), with scores ranging from 1 (the highest level of EBM) to 5 (the lowest level). The average level of EBM was also evaluated for each month from February through September. Finally, we analyzed the interval (in days) between submission and acceptance for publication as well as the percentage of manuscripts that required revision before being accepted.
    Results: Our search yielded a total of 425 relevant publications. Of these publications, 359 (84.5%), 59 (13.9%), and 7 (1.6%) were rated as level 5, 4, and 3, respectively; none of the publications was rated as level 1 or 2. From February 2020 through September 2020, we found a significant increase in the relative proportion of level 3 and 4 publications compared to level 5 publications (rho = 0.108, p=0.024). Moreover, the number of citations per article was significantly correlated with the level of EBM (rho = 2.44, p < 0.0005); however, we found no correlation between the number of citations and either the month of publication or the ranking of the journal in which the article was published. The mean interval between submission and acceptance for publication was 20.4 days (SD: 20.2 days), and 48.2% of submitted manuscripts were accepted without revision. From February through September, the interval between submission and acceptance increased significantly (rho = 0.515, p < 0.0005); however, we found no significant change in the percentage of publications that were accepted without revision over this same time period.
    Conclusions: In the early months of the COVID-19 pandemic, primarily lower-level EBM articles were published, and these publications were accepted relatively quickly. However, this effect was temporary, and over time the EBM levels improved and the interval between submission and acceptance increased, indicating an increase in publication standards.
    DOI:  https://doi.org/10.1155/2022/3539134
  28. Clin Kidney J. 2022 Apr;15(4): 593-602
      The year 2021 was the last full year of Alberto Ortiz's editorship at Clinical Kidney Journal (CKJ). On May 2022, Maria José Soler will start her term as the Editor-in-Chief. Over these years, CKJ obtained its first journal impact factor and has consolidated its position among the top journals in the field, consistently ranking among the top 25% (first quartile) journals in Urology and Nephrology. The 2020 journal impact factor rose to 4.45, becoming the top open access journal in Nephrology and the ninth ranked Nephrology journal overall. We now review the recent history of the journal and the most highly cited topics which include the epidemiology of kidney disease, chronic kidney disease topics, such as the assessment and treatment of chronic kidney disease, onconephrology, cardionephrology, glomerular disease, transplantation and coronavirus disease 2019 (COVID-19).
    Keywords:  Clinical Kidney Journal; ERA Registry; chronic kidney disease
    DOI:  https://doi.org/10.1093/ckj/sfac023
  29. OTO Open. 2022 Jan-Mar;6(1):6(1): 2473974X221088282
       Objective: This study aims to characterize the top-ranked departments in otolaryngology to provide an indicator of the state of diversity within otolaryngology and to draw a comparison with other medical and surgical fields.
    Study Design: This cross-sectional study examined the 20 highest-ranked otolaryngology programs according to the US News & World Report ranking of best hospitals for ear, nose and throat.
    Setting: Academic otolaryngology departments in the United States.
    Methods: Faculty demographic and biographical data were collected from departmental websites. The Web of Science h-index was used as a surrogate for academic productivity. Descriptive statistics and chi-square analysis were used to characterize the cohort and compare otolaryngology with other fields.
    Results: Of 562 otolaryngologists on faculty at the 20 highest-ranked programs, 413 (73.5%) were men and 149 (26.5%) were women. Among the faculty in the cohort, 174 (31.0%) were professors, 145 (25.8%) were associate professors, and 183 (32.6%) were assistant professors. Across faculty appointments, the proportion of women grew smaller as academic rank increased. When compared with all faculty across US medical schools, the departments in this study had significantly lower proportions of female professors (P = .0047), associate professors (P = .0009), and assistant professors (P = .0005). Male faculty members had higher h-indices than their female counterparts among professors (P = .004), associate professors (P = .008), assistant professors (P = .0002), and clinical assistant professors (P = .0009).
    Conclusion: Women are underrepresented across all academic ranks in top-ranked otolaryngology programs. The current state of diversity in otolaryngology yields many opportunities to advance representation for women in the field.
    Keywords:  academic medicine; diversity; faculty
    DOI:  https://doi.org/10.1177/2473974X221088282
  30. Rev Esp Enferm Dig. 2022 Apr 04.
       BACKGROUND: Review of retracted articles has a positive impact on scientific research. The aim of our study was to examine the characteristics of retracted articles in the field of pancreatic diseases.
    METHODS: The Retraction Watch database was queried for retractions in pancreatic diseases on 7 March 2021, and the filters set were as follows: (1) the Title typed in was "pancreatitis", "pancreas", or "pancreatic"; (2) the Nature of notice selected was "retraction".
    RESULTS: A total of 116 retracted articles were identified as pancreatic disease-related, with over two-thirds of them pertaining to pancreatic cancer. Research article was the most common article type among these retractions. Common reasons given for retraction included scientific fraud (37.1%), duplication (26.7%), and reliability (25%). China had the largest number of retractions (n=51), followed by the United States (n=47). Most articles were retracted in recent years, particularly after 2015.
    CONCLUSIONS: A large proportion of retracted articles pertaining to pancreatic diseases have been retracted in recent years. The majority of publications-over three quarters-were retracted for authors who committed some type of misconduct. Differences between countries in the manner of misconduct were stark.
    DOI:  https://doi.org/10.17235/reed.2022.8817/2022
  31. BMJ Open. 2022 Apr 04. 12(4): e056053
       OBJECTIVES: The medical field is facing a clinician-scientist shortage. Medical schools could foster the clinician-scientist workforce by offering students research opportunities. Most medical schools offer elective research programmes. Subsequently, a subset of doctors graduates without any research experience. Mandatory research projects may be more sufficient to develop clinician-scientist, but take more supervision and curricular time. There is limited insight in the scientific outcomes of mandatory research experiences. This study aims to examine publication rates of a mandatory research experience, identify factors associated with publication, and includes postgraduate research engagement.
    DESIGN AND SETTING: Prospective follow-up study involving 10 cohorts of medical students' mandatory research projects from Leiden University Medical Center.
    PARTICIPANTS: All medical students who conducted their research project between 2008 and 2018 (n=2329) were included.
    MAIN OUTCOME MEASURE: Publication rates were defined as peer-reviewed scientific publications, including research papers, reviews, and published meeting abstracts. Postgraduate research engagement was defined as research participation and dissemination of research at scientific conferences or in journals.
    RESULTS: In total, 644 (27.7%) of all mandatory research experiences resulted in publication, with students mainly as first (n=984, 42.5%) or second author (n=587, 25.3%) and above world average citation impact (mean normalised journal score 1.29, mean normalised citation score 1.23). Students who conducted their research in an academic centre (adjusted OR 2.82; 95% CI 2.10 to 3.77), extended their research (adjusted OR 1.73; 95% CI 1.35 to 2.20), were involved in an excellency track (adjusted OR 2.08; 95% CI 1.44 to 3.01), or conducted clinical (adjusted OR 2.08; 95% CI 1.15 to 3.74) or laboratory (adjusted OR 2.16; 95% CI 1.16 to 4.01) research published their research more often. Later as junior doctors, this group significantly more often disseminate their research results at scientific conferences (adjusted OR 1.89; 95% CI 1.11 to 3.23) or in journals (adjusted OR 1.98; 95% CI 1.14 to 3.43).
    CONCLUSIONS: Our findings suggest that a significant subset of hands-on mandatory research projects with flexible learning pathways result in tangible research output with proper impact and that such successful experiences can be considered as diving board towards a research-oriented career.
    Keywords:  EDUCATION & TRAINING (see Medical Education & Training); MEDICAL EDUCATION & TRAINING; STATISTICS & RESEARCH METHODS
    DOI:  https://doi.org/10.1136/bmjopen-2021-056053
  32. Scientometrics. 2022 Mar 25. 1-12
      This study aimed to analyze the content of data availability statements (DAS) and the actual sharing of raw data in preprint articles about COVID-19. The study combined a bibliometric analysis and a cross-sectional survey. We analyzed preprint articles on COVID-19 published on medRxiv and bioRxiv from January 1, 2020 to March 30, 2020. We extracted data sharing statements, tried to locate raw data when authors indicated they were available, and surveyed authors. The authors were surveyed in 2020-2021. We surveyed authors whose articles did not include DAS, who indicated that data are available on request, or their manuscript reported that raw data are available in the manuscript, but raw data were not found. Raw data collected in this study are published on Open Science Framework (https://osf.io/6ztec/). We analyzed 897 preprint articles. There were 699 (78%) articles with Data/Code field present on the website of a preprint server. In 234 (26%) preprints, data/code sharing statement was reported within the manuscript. For 283 preprints that reported that data were accessible, we found raw data/code for 133 (47%) of those 283 preprints (15% of all analyzed preprint articles). Most commonly, authors indicated that data were available on GitHub or another clearly specified web location, on (reasonable) request, in the manuscript or its supplementary files. In conclusion, preprint servers should require authors to provide data sharing statements that will be included both on the website and in the manuscript. Education of researchers about the meaning of data sharing is needed.
    Supplementary Information: The online version contains supplementary material available at 10.1007/s11192-022-04346-1.
    Keywords:  COVID-19; Coronavirus; Data sharing; Open data; Preprint server; SARS-CoV-2
    DOI:  https://doi.org/10.1007/s11192-022-04346-1
  33. Comp Med. 2022 Apr 08.
      Multiple recent surveys have examined the prevalence of female first or senior authors on publications for various scientificand medical disciplines. First and senior authorships are significant achievements for purposes of professional advancement, especially in academia. Such surveys can also provide information regarding diversity and inclusion. In this report, we present the findings of a survey performed to assess how frequently female contributors were first or senior authors in 2 of the most widely-circulated peer-reviewed journals of laboratory animal medicine and science in the United States; data were collected at 3 time points over a recent 20-y span. These data were then compared against estimated populations of potential female authors, as determined from membership rolls in the American Society of Laboratory Animal Practitioners and theAmerican College of Laboratory Animal Medicine. Survey results suggest that female authors increased their representationas influential authors over time, in contrast to representation trends reported for other disciplines. However, whether thisincrease has mirrored the increase in women overall in the veterinary profession during this time span is unknown. In an era of greater attention and sensitivity to equity and inclusion, this survey is offered as a starting point for further conversation within the field of laboratory animal medicine and science.
    DOI:  https://doi.org/10.30802/AALAS-CM-21-000041
  34. Diabetes. 2021 Aug 01. 70(8): 1623-1633
      Women are broadly underrepresented in scientific leadership positions and their accomplishments are not provided equal recognition compared with those of men, but the imbalance in the field of diabetes is unknown. Hence, we analyzed multiple aspects of historical and present-day female representation in the diabetes field.We quantified gender representation at annual American Diabetes Association (ADA) meetings; editorial board service positions for ADA and the European Association for the Study of Diabetes (EASD) journals; principal investigators for ADA, JDRF, and National Institutes of Health National Institute of Diabetes and Digestive and Kidney Diseases P30 grant funding; and ADA, JDRF, and EASD award recipients. There are many women in the field of diabetes: registration for the ADA Scientific Sessions has been 43% female since 2016, and for over five decades, women comprised 83% of ADA Presidents of Health Care and Education. Yet, only 9% of ADA Presidents of Medicine and Science have been women. Women were well represented on editorial boards for journals focused on diabetes education (Diabetes Spectrum, 89% female) and primary care (Clinical Diabetes, 49% female) but not for the more academically targeted Diabetes Care (34% female), Diabetes (21% female), and Diabetologia (30% female). Only one-third of ADA Pathway to Stop Diabetes and JDRF grants have been awarded to women, and females only lead 2 of 18 (11%) of the P30-supported Diabetes Research Centers. Finally, only 2-12% of major ADA, JDRF, and EASD awards were given to women, without significant change over time. Despite increasing recognition of gender imbalance in research and medicine, many disparities in the field of diabetes persist. We call for decreasing barriers for advancement of female investigators and creating environments that promote their retention and equitable recognition for their contributions to the field.
    DOI:  https://doi.org/10.2337/db21-0052
  35. Proc Natl Acad Sci U S A. 2022 Apr 19. 119(16): e2118853119
      Significance In economics, as in many high-skilled professions, women are underrepresented. Web-scraped data provide information on the situation of women in economics around the globe. We document the underrepresentation of women for a large set of countries using the same objective method. We find differences between countries and regions, which might reflect cultural aspects and norms. Europe is more gender-equal than the United States; institutions that are higher ranked in terms of research output have fewer women in senior positions than lower-ranked institutions. In the United States, this also holds for junior positions. The paper thus further informs the debate and shows how female ratios differ on a global scale.
    Keywords:  academic hierarchies; gender equality; leaky pipeline
    DOI:  https://doi.org/10.1073/pnas.2118853119
  36. BMJ Open. 2022 Apr 04. 12(4): e059445
       INTRODUCTION: Many predatory journals fail to follow best publication practices. Studies assessing the impact of predatory journals have focused on how these articles are cited in reputable academic journals. However, it is possible that research from predatory journals is cited beyond the academic literature in policy documents and guidelines. Given that research used to inform public policy or government guidelines has the potential for widespread impact, we will examine whether predatory journals have penetrated public policy.
    METHODS AND ANALYSIS: This is a descriptive study with no hypothesis testing. Policy documents that cite work from the known predatory publisher OMICS will be downloaded from the Overton database. Overton collects policy documents from over 1200 sources worldwide. Policy documents will be evaluated to determine how the predatory journal article is used. We will also extract epidemiological details of the policy documents, including: who funded their development, the discipline the work is relevant to and the name of the organisations producing the policy. The record of scholarly citations of the identified predatory articles will also be examined. Findings will be reported with descriptive statistics using counts and percentages.
    ETHICS AND DISSEMINATION: No ethical approval was required for this study since it does not involve human or animal research. Study findings will be discussed at workshops on journalology and predatory publishing and will be disseminated through preprint, peer-reviewed literature and conference presentations.
    Keywords:  EPIDEMIOLOGY; ETHICS (see Medical Ethics); Health policy; Protocols & guidelines
    DOI:  https://doi.org/10.1136/bmjopen-2021-059445
  37. BMJ Open. 2022 Apr 07. 12(4): e059216
       OBJECTIVES: We assessed the effect of gender, rank and research productivity on compensation for faculty at academic medical centres.
    DESIGN: A web-based retrospective review of salary for professors in 2016.
    SETTING: Faculty from six state-run, publicly funded academic medical centres in the Western USA.
    PARTICIPANTS: 799 faculty members, 225 assistant (51% women), 200 associate (40% women) and 374 full professors (32% women) from general surgery (26% women), obstetrics and gynaecology (70% women) and radiology (34% women).
    METHODS: Archived online faculty profiles were reviewed for gender, rank and compensation (total, baseline and supplemental). Total compensation was defined as baseline compensation plus supplemental income. Baseline compensation was defined as base salary minus reductions due to participation in the voluntary Employee Reduction in Time and phased retirement programmes. Supplemental income was defined as additional salary for clinical care and research (eg, grants). Elsevier's Scopus was used to collect data on h-index, a measure of research productivity. Linear regression models were estimated to determine the relationship between these factors and salary.
    RESULTS: Total compensation was significantly higher for men across all professorial ranks in both general surgery [Formula: see text] and obstetrics and gynaecology [Formula: see text]. Women faculty members within these departments earned almost US$75 000 less than their men colleagues. The disparity in salary originates from gaps in supplemental income, as baseline compensation was not significantly different between men and women. No significant gender difference in total compensation for radiology was found [Formula: see text]. Higher h-index was associated with higher baseline compensation across all departments as well as with supplemental income for general surgery. Higher h-index was related to lower supplemental income for radiology and was not related to supplemental income for obstetrics and gynaecology.
    CONCLUSIONS: Further investigations should focus on discrepancies in supplemental income, which may preferentially benefit men.
    Keywords:  HEALTH ECONOMICS; Health policy; MEDICAL EDUCATION & TRAINING
    DOI:  https://doi.org/10.1136/bmjopen-2021-059216