bims-evares Biomed News
on Evaluation of research
Issue of 2022–02–06
forty-four papers selected by
Thomas Krichel, Open Library Society



  1. World Neurosurg. 2022 Jan 27. pii: S1878-8750(22)00109-7. [Epub ahead of print]
       OBJECTIVE: Extracranial-intracranial (EC-IC) bypass is a procedure in which a blood vessel outside the skull is connected to one inside the skull to improve cerebral blood flow. Certain aneurysms cannot be treated through standard clipping, and EC-IC bypass may be recommended in such cases. A vast body of literature exists on the use of EC-IC bypass as a treatment for cerebrovascular disorders. While beneficial to surgeons, these publications may not reach all the intended audience, which encourages the use of bibliometric analyses. Although a fraction of historically meaningful publications may not have been sufficiently valued through citation count, bibliometric analysis is the gold standard for assessing the impact of a publication.
    METHODS: Using bibliometric analysis, we queried the Web of Science database to identify the 50 most impactful publications on EC-IC bypass based on citation count.
    RESULTS: The literature search retrieved 125 publications that met inclusion criteria, from which the top 50 most-cited ones were selected. The mean number of citations for each article was 117.06 (range 35-1437). Case reports and series constituted 15 (30%) of the top 50 publications on EC-IC bypass, followed by 8 (16%) editorials and 7 (14%) randomized controlled trials. A total of 265 authors in 10 countries contributed to the 50 manuscripts, which were published in 15 different journals.
    CONCLUSIONS: We retrieved the top 50 most-cited articles on EC-IC bypass surgery and identified the landmark publications to provide a foundational understanding of the procedure as a treatment for complex disorders.
    Keywords:  Bibliometric analysis; EC-IC bypass; extracranial bypass; intracranial bypass
    DOI:  https://doi.org/10.1016/j.wneu.2022.01.095
  2. World J Clin Cases. 2022 Jan 14. 10(2): 594-606
       BACKGROUND: Despite the overload of publications on Crohn's disease (CD), no comprehensive analysis of biologic therapy for CD has been reported.
    AIM: To determine knowledge gaps and identify areas of interest of biologic therapy for CD.
    METHODS: The top 100 highest-cited original articles were identified from January 1991 to December 2020 in the Clarivate Analytics Web of Science Core Collection database. We conducted a bibliometric analysis of biologic therapy for CD based on total citations, summarized the bibliographic information of the articles related to CD biologic therapy, and explored the research hotspots.
    RESULTS: The top 100 highest-cited original articles were identified with total citations ranging from 307 to 2978. The 2000s (Period II, n = 66) yielded the most influential original articles and saw the most dramatic growth. Among the top 10 countries, including 8 European countries and 2 North American countries, the United States (n = 37) and Belgium (n = 20) contributed the most publications. Among the top 10 institutions, the University Hospital Gasthuisberg in Belgium (n = 23), the University of Chicago in the United States (n = 20), and the Mayo Clinic in the United States (n = 17) published the most papers. Regarding authors, Rutgeerts P in Belgium (n = 32), Sandborn WJ in the United States (n = 23), and Feagan BG in Canada (n = 18) published the highest number of studies. The cooperation relationships between the United States and Europe were most frequent. Gastroenterology (impact factor = 22.682) published the most articles on biologic therapy for CD (n = 32) with 17654 total citations. Anti-tumor necrosis factor biologics and monoclonal antibodies were the most studied topics.
    CONCLUSION: The bibliometric analysis emphasized the key contributions to the development of the specialized field. These data would provide useful research insights into biologic therapy for CD for clinicians and researchers.
    Keywords:  Bibliometric analysis; Biologic therapy; Crohn’s disease; Insight; Most influential
    DOI:  https://doi.org/10.12998/wjcc.v10.i2.594
  3. J Pak Med Assoc. 2022 Jan;72(1): 84-92
       OBJECTIVE: To analyse characteristics of literature related to dental research and education published in a single medical journal, The Journal of Pakistan Medical Association.
    METHODS: The bibliometric study was conducted at the Sindh Institute of Oral Health Sciences, Jinnah Sindh Medical University from March till May 2020, and comprised electronic and hand search of scientific literature relevant to dentistry published in the Journal of Pakistan Medical Association from the first issue published in 1953 till March 2020. The selected articles were analysed for year of publication, field of study, type of article, institute and country of first author, number of authors and citation count. Keyword mapping was also carried out. Data was analysed using SPSS 19.
    RESULTS: Of the 159 articles identified, 117(73.6%) were contributed from Pakistan. The most common specialties were Oral and Maxillofacial Surgery and Epidemiology with 20(12.6%) articles each, followed by Operative Dentistry and Endodontics 19(11.9%). Majority of articles were Original / Research 87(54.7%). The highest number of articles were published in 2019 26(16.35%). The Aga Khan University, contributed the most publications 30(18.9%), followed by Dow University of Health Sciences, 11(6.9%). Majority of the articles were contributed by three authors 48(38.4%). The top cited article was found to have 113 citations, followed by articles with 103 and 91 citations.
    CONCLUSIONS: The contribution of scientific papers related to dentistry and dental education in the Journal of Pakistan Medical Association was significant. With growth of dentistry as a discipline along with a parallel increase in the publication of dental research papers, it is imperative that a dedicated indexed journal for dental research be commenced.
    Keywords:   Bibliometric study, Dental literature, JMPA, J Pak Med Assoc.
    DOI:  https://doi.org/10.47391/JPMA.2192
  4. Int Orthop. 2022 Jan 31.
       PURPOSE: To determine trends and hot subjects in the field of oblique lumbar interbody fusion (OLIF) research during the last decade using bibliometric analysis and visualization tools, in order to assist researchers in exploring new directions for future research in that field.
    METHODS: Articles published from January 1, 2012, to August 15, 2021, were screened in the Web of Science database. The data were analyzed with CiteSpace software, which generated visualization knowledge maps. All literature was assessed for the following parameters: the number of total publications, distribution, h-index, institutions, journals, authors, co-occurrence state, and research hotspots.
    RESULTS: A total of 173 articles were identified. The country with the largest number of articles was China (41.04%), followed by South Korea (20.81%), the USA (15.61%), Japan (9.83%), and Thailand (2.89%). South Korea and the USA had the highest h-index (9), followed by China (8), Japan (7), and Thailand (2). Catholic University of Korea was the organization that produced the most literature. World Neurosurgery published the most papers about OLIF (12.50%), but articles in Spine were most frequently cited (151). Kim JS was the most productive author, whereas Silvestre C was the most cited author. The main research hotspots are anatomy, discectomy, approach, injure, and diseases.
    CONCLUSIONS: The number of publications in the field of OLIF has increased considerably in recent years. The USA, China, South Korea, and Japan have made substantial contributions to this field. Anatomy, complications, decompression surgery, and application in various degenerative lumbar diseases have been the research hotspots in recent years.
    Keywords:  Bibliometric analysis; Oblique lumbar interbody fusion; Research productivity; Research trends; Visualization
    DOI:  https://doi.org/10.1007/s00264-022-05316-1
  5. Cureus. 2021 Dec;13(12): e20694
      With the many papers published in the field of pediatric neurosurgery, it is often difficult to recognize those that have the most impact on future papers, i.e., citable papers. However, citation analysis allows one to better understand which papers are impacting the field the most. Therefore, the current study aimed to evaluate this literature. The Journal Citation Report database was searched for publications with the words "pediatric neurosurgery" or "pediatric neuro" in the title. Using the Web of Science Core Collection, the top 100 journal articles in pediatric neurosurgery from the selected journals were identified and citation analysis was used to identify the most impactful articles. A search was performed on Web of Science Core Collection by searching for each journal under "Publication Name" and using the Boolean "OR" function to separate fields. The results were ordered by the "Times Cited" category, which provided a list of all the articles from the eight journals appearing in the most cited order. The timeline used was from 1976 to 2021. The top 100 most cited articles were extracted from this list for analysis. The following variables were collected from each scientific article: publication journal, impact factor of journal, title, number of citations, year and month of publication, and type of article. Eight journals were identified on the basis of our search criteria and the articles were sorted by most cited; 1609 pediatric neurosurgery journal articles were screened to select the 100 most cited since 1976. This compilation could serve to help clinicians and researchers to familiarize themselves with the journal articles included in terms of study type, study field, journal of publication, and recurring authors.
    Keywords:  category; citation; journal; pediatric neurosurgery; publication
    DOI:  https://doi.org/10.7759/cureus.20694
  6. Med Sci Monit. 2022 Feb 03. 28 e934016
      BACKGROUND Tendinopathy is a tendon disease that often occurs in athletes. Many studies have revealed that exercise therapy is beneficial for the nonoperative management of tendinopathy. However, the general aspect bibliometric analysis of this global research topic associated with exercise and tendinopathy is lacking. The present study aimed to make a bibliometric analysis of worldwide development tendency and research hotspots in exercise and tendinopathy research from 2001 to 2020. MATERIAL AND METHODS Using the Web of Science, articles and reviews published between 2001 and 2020 were retrieved from the Science Citation Index Expanded database. CiteSpace was used to analyze the relationship among publications, countries, institutions, journals, authors, references, and keywords. RESULTS In total, 857 articles were found in this study. Over the past 20 years, there was a marked increase in the number of publications. A total of 194 different scholarly journals were dedicated to the categories Sport Sciences, Orthopedics, and Rehabilitation. The USA and La Trobe University were the most prolific country and institution, respectively. The British Journal of Sports Medicine was the prominent journal for research on exercise and tendinopathy and had the most publications. The analysis of keywords showed that rehabilitation, rotator cuff tendinopathy, stiffness, and disability of individuals with tendinopathy had become the research focus in this field. CONCLUSIONS Bibliometric analysis provides a historical and scientific perspective on exercise and tendinopathy research, providing relevant researchers, funding agencies, and policymakers with valuable information to explore the current research status, hotspots, and new directions for future research.
    DOI:  https://doi.org/10.12659/MSM.934016
  7. Front Bioeng Biotechnol. 2021 ;9 795341
      To gain insight into the trend of bacterial nanocellulose research, a bibliometric analysis was performed using the Science Citation Index Expanded database from 2005 to 2020. The study concentrated on the publication's performance in terms of annual outputs and citations, mainstream journals, categories of the Web of Sciences, leading countries, prominent institutions, and trends in research. Current research priorities and future trends were analyzed after summarizing the most commonly used keywords extracted from words in the paper title analysis, authors' keyword analysis, and KeyWords Plus. The findings revealed that the annual output in the form of scholarly articles on bacterial nanocellulose research steadily increased during the first quartile of the study period, followed by a very rapid increase in the last five-years of the study. Increasing mechanical strength would remain the main future focus of bacterial nanocellulose research to create its scope in different field of applications.
    Keywords:  CPPyear; Cyear; SCI-EXPANDED; TCyear; bacterial nanocellulose; front page; scientometrics
    DOI:  https://doi.org/10.3389/fbioe.2021.795341
  8. Transl Cancer Res. 2021 Mar;10(3): 1204-1215
       Background: Cancer is one of the most lethal diseases in the world, and photothermal therapy was reported recently as a new and effective therapy for cancer. This study offers the bibliometric and visualization analysis of photothermal therapy on cancer.
    Methods: A record of 6,233 papers in this field from 1995 to 2019 was obtained based on the Web of Science Core Collection (WoSCC). And CiteSpace was used to analyze the annual trends of publications, countries, institutions, journals, co-cited references, and keywords in the field of photothermal therapy on cancer.
    Results: We identified that the number of publications continually increased over the time. The most productive country and institution in this field was China and Chinese Academy of Sciences, respectively. The ACS Appl Mater Interfaces was the most active journal. Co-cited references analysis revealed the top landmark articles in the field. Co-occurrence keywords and their clustered network were analyzed, revealing that materials, especially nanomaterials, used in photothermal therapy, remained the hotspots in this research field. Timezone view and burst detection of keywords showed that nanomaterials were always the hotspots and the frontier topics in this field.
    Conclusions: The current study revealed that photothermal therapy has become a subject of growing study and a very important research area. In addition, the research of materials in photothermal therapy, especially nanomaterials, which were applied in photothermal therapy to treat cancer effectively, is the foci and the frontier topic in this field.
    Keywords:  CiteSpace; Photothermal therapy; cancer; nanomaterials; visualization analysis
    DOI:  https://doi.org/10.21037/tcr-20-2961
  9. Skin Appendage Disord. 2022 Jan;8(1): 20-23
       Introduction: Hidradenitis suppurativa (HS), once an orphan disease, has gained increased interest world-wide. The most highly cited works in HS are from North America and Europe despite known phenotypic and epidemiological differences globally. Herein, we perform a bibliometric analysis to characterize HS publication trends in Asia and Australasia (AA) over the last decade.
    Methods: PubMed database was searched to identify HS-related articles and were analyzed for senior authorship, country of origin, article topic, and study design.
    Results: The search criteria yielded 163 articles from AA. Rapid increase in publications started in 2015 with 75% (123/163) of total articles published in the last half of the decade. Case reports/series were consistently the most published study type yearly and overall (49%, 80/163). Efforts were made to increase high level of evidence publications with both randomized controlled trials from Japan and Turkey including all Asian patients. China, Japan, and India were the leading publishing countries with Australia, Israel, and Turkey increasingly contributing in the last half of the decade.
    Conclusions: Advancements in HS research are encouraging with increases in publication numbers and diversity; however, more geographical diversity is needed in order to garner a better understanding of the disease and treatment options.
    Keywords:  Acne inversa; Asia; Australasia; Bibliometric; Hidradenitis suppurativa; Publications
    DOI:  https://doi.org/10.1159/000518045
  10. J Pharm Innov. 2022 Jan 22. 1-13
       Objective: The study quantitatively investigated the related research progress in pharmaceutical sciences/pharmacy education from a bibliometric angle and provided feasible suggestions to facilitate the development of pharmaceutical sciences/pharmacy postgraduate education.
    Methods: Bibliometric analysis was conducted using the database of Web of Science Core Collection. The literature published in 1985-2021 was screened and selected. The overall profile description, citation analysis, and research hotspot mining were performed using the citation report of Clarivate Analytics, bibliometrics online platform, and VOSviewer software. The bibliometric results and profiles were plotted and illustrated.
    Results: The bibliometric analysis of 485 papers of interest showed that the research frontier was continuously expanding; especially the institutions from the USA were the main contributors. The numbers of citing papers have been ascending, and a considerable part of citations were from the areas other than the education research. Mining results showed that the in-school and residency education of pharmacy postgraduates was a research hotspot, as well as interprofessional training and new education styles for Coronavirus Disease 2019 (COVID-19) therapy were the emerging trends in the field.
    Conclusion: Through the analysis of the studies, it was found that encouraging relevant research programs, establishing financial supports, and launching specified publication sources could be helpful to boost the development of pharmaceutical sciences/pharmacy postgraduate education. Besides, the results suggested that this was a less discussed topic and was worthy for the investigators to pay more attention to such an issue.
    Supplementary Information: The online version contains supplementary material available at 10.1007/s12247-021-09611-z.
    Keywords:  Bibliometric; Pharmaceutical sciences; Pharmacy; Postgraduate education; Web of science
    DOI:  https://doi.org/10.1007/s12247-021-09611-z
  11. Transl Cancer Res. 2021 Aug;10(8): 3606-3618
       Background: Thousands of papers on testicular germ cell tumor (TGCT) have been published over the past two decades. This study aimed to assess the key topics and future trends in TGCT research from a comprehensive perspective.
    Methods: All literature defined as review and article type on TGCT published between 2000 and 2020 was identified and retrieved from the Web of Science Core Collection (WoSCC) database. Bibliometric analysis was conducted by the online analysis platform and VOSviewer (version 1.6.16). The key directions and future trends in the research field of TGCT were evaluated using Bibliographic Item Co-occurrence Matrix Builder (version 2.0) and gCLUTO software.
    Results: Ultimately, a total of 4,550 papers between 2000 and 2020 were included in the field of TGCT. The leadership of the United States in global TGCT research with 1,549 publications during the last two decades was obvious. The Indiana University was the most productive institution with 360 publications, and it was also the institution most frequently involved in research cooperation. Journal of Urology published the highest number of publications on TGCT. Looijenga LHJ, Bokemeyer C, Ulbright TM, Sheinfeld J and Dieckmann KP were the top productive contributors to TGCT research. Further, five research hotspots have been identified: (I) epidemiology of TGCT; (II) TGCT-related infertility; (III) pathological classification with TGCT; (IV) management options for TGCT; and (V) Prevention of cancer metastasis in TGCT patients.
    Conclusions: During the last two decades, the United States was a global leader, and research hotspots included epidemiology, male infertility, pathology, and therapy in the field of TGCT. Furthermore, the genetics mechanisms and cisplatin resistance will remain hotspots in future TGCT research.
    Keywords:  Testicular germ cell tumor (TGCT); bibliometric analysis; research hotspots
    DOI:  https://doi.org/10.21037/tcr-21-412
  12. Front Res Metr Anal. 2021 ;6 793853
      Meat production plays a vital socioeconomic role for sustainable development and for promoting food security in most countries. However, not much is known about research agendas done globally and the advancement of knowledge-generating networks in this area of study. The present study aims to reveal and analyze scientific research outputs on meat production linked with recent nanotechnology research work done till date. A compilation of research advancement and development within the sphere was realized through a scientometric study to comprehend the trend of research outputs, scientific impacts, authors' involvement, collaboration networks, and the advancement of knowledge gaps for future research endeavors on the current subject matter. Scholarly published articles were retrieved from the web of science (WOS) and Scopus databases from 1985 to 2020 and they were merged together using bibliometric package in R studio. All duplicated articles (438) from both data bases were excluded. A combination of terms (nano* AND (livestock* OR meat* OR beef* OR mutton* OR pork* OR chevon* OR chicken* OR turkey*)), and conversely analyzed for scientometric indices. A collection of 656 peer-reviewed, research articles were retrieved for the study period and authored by 2,133 researchers with a collaboration index of 3.31. The research outputs were highest in the year 2020 with total research outputs of 140 articles. The topmost three authors' keywords commonly used by authors were nanoparticles, meat, and chitosan with a respective frequency of 75, 62, and 57. China, Iran, and India ranked top in terms of meat production research outputs linked to nanotechnology and total citation with respective article productivity (total citations) of 160 (3,193), 111 (1,765), and 37 (552). Our findings revealed an increasing trend in research (with an annual growth rate of 25.18%) tending toward advancing meat production with the use of nanotechnology. Likewise, there is an increasing pointer to the fact that research work on nanotechnology and meat production has the prospect to influence positively, decision-making on research direction, and collaborations, hereby increasing the production of meat and its products in the future.
    Keywords:  bibliometric study; food security; global trend; meat production; nanomaterials
    DOI:  https://doi.org/10.3389/frma.2021.793853
  13. Front Mol Biosci. 2021 ;8 797902
      Objective: To analyze the research hot spots and frontiers of molecular mechanisms of exercise on cancer via CiteSpace. Method: Related publications in the Web of Science Core Collection Science Citation Index Expanded were retrieved from inception to November 27th, 2021. Then we used CiteSpace to generate network maps and identify top authors, institutions, countries, keywords, co-cited authors, journals, references and research trends. Results: A total of 1,130 related publications were retrieved. The most productive author and journal were Lee W Jones and PLOS ONE. Hanahan D and Warburg O were the most cited authors. Fudan University and Shanghai Jiao Tong University were the leading institutions, while China was the leading country. Top-cited authors and references generally focused on the epidemiology and hallmarks of cancer. Top five keywords with both high frequency and high betweenness centrality were breast cancer, aerobic glycolysis, oxidative stress, gene expression, skeletal muscle. Keyword "warburg effect" ranked first with the highest citation burst, while "inflammation", "hepatocellular carcinoma", "epithelial mesenchymal transition", and "adipose tissue" were emerging research foci. Conclusion: This study analyzed the research hot spots and frontiers of molecular mechanisms of exercise on cancer via CiteSpace. Based on the results, altered metabolism (aerobic glycolysis, insulin resistance, myokines), oxidative stress, gene expression and apoptosis were hot-research mechanisms of exercise on cancer. Emerging research foci of mechanisms were generally around inflammation, epithelial mesenchymal transition and adipokines. In addition, future studies could carry in-depth research of interactions between different mechanisms and try to elucidate the recommended doses and intensities of exercise for cancer, especially in breast, colorectal, prostate cancer and hepatocellular carcinoma.
    Keywords:  bibliometrics; cancer; citespace; exercise; molecular mechanisms; visualization analysis
    DOI:  https://doi.org/10.3389/fmolb.2021.797902
  14. Arterioscler Thromb Vasc Biol. 2022 Feb 03. ATVBAHA122317426
      There are many metrics to evaluate the performance and status of journals. Among these, the journal impact factor (JIF) has become the dominant metric. The influence of JIF is illustrated by its widespread use to evaluate academic status, compensation, and funding decisions. However, as noted by Clarivate Analytics, the parent company of the web of science (WoS), the JIF should not be used without careful attention to the many phenomena that influence citation rates. To facilitate transparency, Clarivate Analytics provides all data used to determine the JIF. In addition, WoS provides other metrics for journal evaluation, including the article citation median and the review citation median. These metrics are represented as medians to minimize the confounding influence of a small number of highly cited articles that may occur when data are represented as means. Another feature of these WoS metrics is that data are separated according to different publication types of article (original research and review). To systematically compare these selected metrics, we used the data provided on the WoS web site to analyze 25 top ranked cardiovascular journals in the same mode as represented in the WoS citation distribution window. The results indicate that the article citation median and review citation median overcome several concerns that have been raised about the JIF and seem to provide enhanced objectivity as an indicator of journal impact in publishing original research and reviews. Therefore, we advocate that these additional WoS metrics might be preferentially considered as indicators of journal performance.
    Keywords:  benchmarking; bibliometrics; journal impact factor; periodicals as topic; publishing
    DOI:  https://doi.org/10.1161/ATVBAHA.122.317426
  15. Updates Surg. 2022 Jan 30.
      Metabolic surgery has become a powerful treatment for obese type 2 diabetes (T2DM). Experts have been devoting to the research of metabolic surgery in the treatment of T2DM. The debate continues, and there is no comprehensive statistical and intuitive analysis for it. To explore the current research status, the latest hotspots and the changing trend in this field, we conducted a bibliometric analysis. This paper made a bibliometric analysis based on the data source from Science Core Collection Network (WoSCC). Vosviewer v.1.6.10 software is used to construct a knowledge map. From 2011 to 2020, 1424 peer-reviewed papers on metabolic surgery for T2DM were retrieved. The United States contributed the most publications and gained global impact with the most citations. Obesity Surgery was the most prolific journal in this field. Prof. Schauer Philip R., Prof. Buchwald H. and Prof. Sjostrom L. were the most renowned experts in this aspect. The top cited references discussed the status of metabolic surgery for the treatment of T2DM worldwide and the importance of regular evaluation. The extracted keywords mainly formed three clusters: (1) research on the selection of different metabolic surgery methods; (2) possible mechanisms; (3) improvement of T2DM complications by metabolic surgery. Our study makes a comprehensive and objective analysis of metabolic surgery in obese patients with T2DM, providing valuable information for further clinical application and related scientific research. Researchers can quickly locate research hotspots in a large number of relevant literature.
    Keywords:  Bibliometric analysis; Metabolic surgery; Obesity; Treatment; Type 2 diabetes; VOSviewer
    DOI:  https://doi.org/10.1007/s13304-021-01201-5
  16. Front Cell Dev Biol. 2021 ;9 793347
      Ferroptosis is an iron-dependent regulated cell-death caused by the accumulation of lipid peroxides, which is different from apoptosis, autophagy, necroptosis and other forms of regulatory cell death in morphology and mechanism. It has attracted interest and attention of scholars from all over the world during the past years. Recent studies have shown that ferroptosis is able to play a clear and important role in cancer treatment, providing a bright prospect for targeted cancer therapy. This article aims to analyze current scientific results about the application of ferroptosis in the field of cancer treatment, providing new ideas for further research. We retrieved publications related to ferroptosis and cancer treatment from 2012 to 2020 from the Web of Science Core Collection (WoSCC), screening them according to the inclusion criteria. A total of 965 related papers were included, and the total number of publications increased year by year. We used CiteSpace 5.7. R2, VOSviewer and Microsoft Excel 2019 to evaluate and visualize the results, analyzing institutions, countries/regions, journals, authors, co-cited reference and keywords. Overall, with more and more evidence showing the indispensable role of ferroptosis in cancer, its mechanism research and target discovery may become the main direction of future research.
    Keywords:  VOSviewer; bibliometric analysis; cancer treatment; citespace; ferroptosis; visualization analysis
    DOI:  https://doi.org/10.3389/fcell.2021.793347
  17. Transl Cancer Res. 2021 Jan;10(1): 251-260
       Background: Bibliometric analysis highlights the pivotal studies and topics that have shaped the understanding and management of a disease in its designated field. Herein, original articles on the applications of nanotechnology in head and neck squamous cell carcinoma (HNSCC) were characterized and analyzed.
    Methods: A comprehensive search was carried out using a bibliometric methodology, and eligible articles on nanomedicine research in HNSCC were retrieved from the Scopus database.
    Results: A total of 309 eligible articles were retrieved, and the total citation count was 7,468. An ascending trend in citation count was observed since 2004, which increased substantially between 2014 and 2019. There were 144 (52.7%) original articles on oral cavity carcinomas. Chemotherapy (n=53, 19.4%), chemoprevention (n=35, 11.3%), and photodynamic therapy (n=23, 8.4%) were the three most published topics on the applications of nanotechnology in the therapy of HNSCC. Sentinel node detection (n=25, 9.2%) and noninvasive cancer diagnosis (n=22, 8.1%) were the two most published topics in the diagnostic area of HNSCC. A vast majority of these articles were preclinical studies, and only four articles (1.5%) were phase I/II clinical studies on chemotherapy and radiotherapy.
    Conclusions: To the best of our knowledge, this is the first study to analyze the bibliometric characteristics of original articles on nanomedicine in HNSCC. The results of this study not only provide a historical perspective on the scientific evolution in this field, but also revealed the trends and key topics within it that may help facilitate further research.
    Keywords:  Bibliometric analysis; head and neck squamous cell carcinoma (HNSCC); nanomedicine; nanotechnology; oral cancer
    DOI:  https://doi.org/10.21037/tcr-20-2852
  18. Arch Bone Jt Surg. 2021 Nov;9(6): 718-721
       Background: Scientometrics is one of the bibliometrics subsets aiming to study the status of scientific development of scientific and research institutes. This study aimed to investigate the scientific status of orthopedic departments in different universities of Iran using the national scientometrics system of the Ministry of Health in Iran.
    Methods: This cross-sectional study investigated the researchers and orthopedic departments in different universities of Iran based on the data from the scientometrics system of the Ministry of Health in Iran until the beginning of 2021. All researchers and publications related to orthopedics, as well as the relationship of these researchers, have been studied part-time and full-time. The number of publications, indexing level, academic degree, and academic position has been also registered and examined through the scientometrics system.
    Results: This study included 280 researchers from different universities in Iran. The mean number of the published articles was 20.6±19.8. The highest number of faculty members were from Iran (n=27; 9.64%), Shahid Beheshti (n=26; 9.28%), Tehran (n=25; 9.28%), as well as Mashhad and Shiraz Universities of Medical Sciences (n=18; 6.42%) in descending order. The overall mean values of the H- and G-index were determined at 5.85±2.7 and 9.3±4.2, respectively. Furthermore, the number of citations per published article was obtained at 6.7±1.3. It should be mentioned that Mashhad University of Medical Sciences obtained the highest H-index (9.6) and G-index (10.6), respectively.
    Conclusion: The scientific productions and publications of the Iranian orthopedic academic institutions were similar to those of the international scientific institutes in terms of H-index and number of citations per published article. It is worth mentioning that Mashhad University of Medical Sciences was the leader in this regard.
    Keywords:  Evaluation; Medical research; Research performance; Scientometry
    DOI:  https://doi.org/10.22038/abjs.2021.55448.2760
  19. Transl Cancer Res. 2021 Aug;10(8): 3757-3771
       Background: Lung cancer is currently the most commonly diagnosed malignant tumor worldwide. Exploring ways to improve the accuracy and timeliness of diagnosis has important clinical significance. Radiomics transforms images into high-dimensional data, and uses deep learning and artificial intelligence to improve the accuracy and efficiency of disease diagnosis. There is an increasing amount of research on radiomics in the diagnosis of lung cancer. This study analyzes the relevant literature in the Science Citation Index Expanded (SCI-E) database to understand the current research status and future development direction of lung cancer radiomics.
    Methods: This study is based on the SCI-E database. The first search formula is topic = Lung cancer OR Lung neoplasms (#1), the second search formula is topic = Radiomics (#2), and the third search formula is #1 and #2, that is, literature that meets both the first and second search results. CiteSpace software was used to analyze lung cancer radiomics from the annual distribution of articles, countries, institutions, journals, and authors and keywords. HistCite software was used to visualize the citation chronology of the lung cancer radiomics literature, and Pajek software was used to analyze the main path of the citation chronology.
    Results: There were a total of 749 publications, of which most were original articles (529, 70.63%) and reviews (109, 14.55%). The citation frequency is 21,676 times, the h-index is 66, and the average number of citations per publication is 28.94. The research mainly comes from the United States of America, China and other countries. The research institutions are mainly medical centers such as Moffitt Cancer Center, Maastricht University and Harvard Medical School. The authors are also mainly from these institutions. The literature was published in many related journals, mainly imaging and oncology journals. Keyword analysis shows that in recent years, research has focused on deep learning and artificial intelligence.
    Conclusions: The field of lung cancer radiomics is developing rapidly, and the main focuses of research are deep learning and artificial intelligence.
    Keywords:  Lung cancer; bibliometrics; radiomics
    DOI:  https://doi.org/10.21037/tcr-21-1277
  20. Cureus. 2021 Dec;13(12): e20731
      Purpose This study sought to assess gender differences among physician faculty in medical biochemistry and genetics programs in North America. It compared the distribution of academic and leadership ranks, years of active research, number of citations and publications, and Hirsch-index (h-index) by gender. Variable associations with the h-index were assessed. Method This was a cross-sectional retrospective study for which data was collected from June 2019 to October 2019 on academic and administrative physician faculty members for medical biochemistry and genetics programs. The website of Fellowship and Residency Electronic Interactive Database, Canadian Resident Matching Service website, and the medical biochemistry profile from the Canadian Medical Association to identify relevant programs and SCOPUS was used to gather faculty data. Results The analyses included 147 faculty members. More male faculty held higher academic rank positions and first-in-command leadership positions than female faculty. Men had more median years of active research, citation numbers, publication numbers, and h-index than women across all academic ranks. Upon performing multivariable linear regression, female faculty showed 0.39 times the odds of having a higher h-index than male faculty, keeping all other variables constant (p<0.01).  Conclusions In our study, it was shown that male physician faculty surveyed had higher performance than female faculty in academic rank and research productivity. Certain barriers may be contributing factors, including lack of mentorship or flexible institutional policies, women choosing clinical educator tracks, or gender bias. Considering the low retention rates of women in academic research, there is a need to address barriers in order to achieve gender parity.
    Keywords:  academic rank; gender-based differences; medical biochemistry; research productivity; retrospective research
    DOI:  https://doi.org/10.7759/cureus.20731
  21. PLoS One. 2022 ;17(2): e0263410
      The number of scholarly journal articles published each year is growing, but little is known about the relationship between journal article growth and other forms of scholarly dissemination (e.g., books and monographs). Journal articles are the de facto currency of evaluation and prestige in STEM fields, but social scientists routinely publish books as well as articles, representing a unique opportunity to study increased article publications in disciplines with other dissemination options. We studied the publishing activity of social science faculty members in 12 disciplines at 290 Ph.D. granting institutions in the United States between 2011 and 2019, asking: 1) have publication practices changed such that more or fewer books and articles are written now than in the recent past?; 2) has the percentage of scholars actively participating in a particular publishing type changed over time?; and 3) do different age cohorts evince different publication strategies? In all disciplines, journal articles per person increased between 3% and 64% between 2011 and 2019, while books per person decreased by at least 31% and as much as 54%. All age cohorts show increased article authorship over the study period, and early career scholars author more articles per person than the other cohorts in eight disciplines. The article-dominated literatures of the social sciences are becoming increasingly similar to those of STEM disciplines.
    DOI:  https://doi.org/10.1371/journal.pone.0263410
  22. Rheumatol Int. 2022 Jan 31.
      Adult-onset Still's disease is a nonfamilial, or sporadic, systemic autoinflammatory disorder accompanied by peak fever ≥ 39 °C, arthralgia or arthritis, skin rashes, leukocytosis (≥ 10,000 cells/mm3) with neutrophils ≥ 80%, and other clinical symptoms. This study aimed to analyze the quantity and quality of publications, and to exhibit the current global status and trend of adult-onset Still's disease research. Searched with the search term 'Adult onset Still disease' on the Web of Science for time limited to 2011-2020. Original articles and reviews were selected. A total of 537 articles were retrieved from 44 countries, of which 13 met the criteria of major active countries. High-income countries contributed 378 articles (70.39%). The number of articles annually increased significantly in the 10-year period (P < 0.001). China (n = 90, 16.76%), Japan (n = 79, 14.71%), Italy (n = 59, 10.99%), the United States (n = 52, 9.68%) and South Korea (n = 45, 8.38%) are the five most productive countries. Adjusted by population, Italy led the top list, followed by South Korea and Israel. According to gross domestic product analysis, Italy ranked first, followed by Portugal and Turkey. A significant correlation was detected between average citations and AAS (P = 0.002), MRC (P < 0.001). From 2011 to 2020, the number of global articles was increasing rapidly. Most papers came from high-income countries. The relationship between the bibliometric and altmetric analyses are basically consistent, therefore the two can prove/complement each other.
    Keywords:  Adult-onset Still’s disease; Altmetric; Bibliometric analysis; Web of Science
    DOI:  https://doi.org/10.1007/s00296-022-05097-1
  23. Front Neurol. 2021 ;12 823474
       Objective: The purpose of this study was to analyze the research status of epilepsy with suicide and to determine the hotspots and frontiers via CiteSpace.
    Method: We searched the Web of Science Core Collection (WoSCC) for studies related to epilepsy and suicide from inception to September 30, 2021. We used CiteSpace to generate online maps of collaboration between countries, institutions, and authors, and revealed hot spots and frontiers in epilepsy with suicide.
    Results: A total of 631 publications related to epilepsy with suicide were retrieved from the WoSCC. Andres M. Kanner was the most published author (25 papers). The USA and Columbia University were the leading country and institution in this field, with 275 and 25 papers, respectively. There were active cooperation between institutions, countries, and authors. Hot topics focused on depression, antiseizure medications, pediatric epilepsy, and risk factors of suicide in patients with epilepsy (PWEs).
    Conclusions: Based on the CiteSpace findings, this study detected active collaboration among countries, institutions and authors. The main current research trends include suicide caused by depression, suicide caused by the use of antiseizure medications, suicide in children with epilepsy, and risk factors for suicide in PWEs. Thus, more attention should be paid to the psychiatric comorbidity of PWEs (especially pediatric epilepsy), the suicidal tendency of PWEs, and the rational use of antiseizure medications in the future.
    Keywords:  CiteSpace; bibliometrics; epilepsy; suicide; visualization analysis
    DOI:  https://doi.org/10.3389/fneur.2021.823474
  24. PeerJ Comput Sci. 2022 ;8 e835
      Science across all disciplines has become increasingly data-driven, leading to additional needs with respect to software for collecting, processing and analysing data. Thus, transparency about software used as part of the scientific process is crucial to understand provenance of individual research data and insights, is a prerequisite for reproducibility and can enable macro-analysis of the evolution of scientific methods over time. However, missing rigor in software citation practices renders the automated detection and disambiguation of software mentions a challenging problem. In this work, we provide a large-scale analysis of software usage and citation practices facilitated through an unprecedented knowledge graph of software mentions and affiliated metadata generated through supervised information extraction models trained on a unique gold standard corpus and applied to more than 3 million scientific articles. Our information extraction approach distinguishes different types of software and mentions, disambiguates mentions and outperforms the state-of-the-art significantly, leading to the most comprehensive corpus of 11.8 M software mentions that are described through a knowledge graph consisting of more than 300 M triples. Our analysis provides insights into the evolution of software usage and citation patterns across various fields, ranks of journals, and impact of publications. Whereas, to the best of our knowledge, this is the most comprehensive analysis of software use and citation at the time, all data and models are shared publicly to facilitate further research into scientific use and citation of software.
    Keywords:  Knowledge graph; Named entity recognition; Software citation; Software mention
    DOI:  https://doi.org/10.7717/peerj-cs.835
  25. Sci Total Environ. 2022 Jan 28. pii: S0048-9697(22)00503-4. [Epub ahead of print] 153411
      The sustainable food supply chain (SFSC) is a research area of global significance. The increasing number of research articles in SFSC justifies this. With 80% of publications in SFSC coming up in the last 7 years, this field is expanding and diversifying at a rapid rate. The research on sustainable food supply chain (SFSC) covers a wide variety of areas and has a wide range of research themes in FSC. To facilitate the theoretical understanding of SFSC, we have conducted a review of the literature on SFSC. With the aim to define prominent research themes in SFSC, we follow an integrated review approach of structured literature review (SLR), bibliometric analysis, and thematic analysis. Bibliometric analysis was conducted using the vosviewer software version 1.6.16. The thematic analysis identified- "Waste management", "SC sustainability and impact assessment", "Decision support", "Operations management and optimization", "Food quality and safety", "Sustainable business models", "Innovation and technological solution", "SC strategy", and "Social sustainability" as the key emergent themes. We discuss the conceptual and theoretical basis of each of these themes. "SC sustainability and impact assessment" is identified as the most dominant theme in SFSC. Innovation and technological solution is an emerging theme with many new publications related to disruptive technologies coming up. Research in collaboration and decision theory-based approaches is important to enable sustainability in FSC. Quantifying waste streams, identifying hotspots are important future directions of research in SFSCM. Circular economy, AFSC, and the use of advanced technologies to enable circularity and sustainability also have great scope. The review aims to help researchers and academicians understand the boundaries and domain of SFSC and the future scope of these themes about how they can enhance the sustainability in SFSC.
    Keywords:  Sustainable food supply chain; Systematic literature review; Thematic analysis
    DOI:  https://doi.org/10.1016/j.scitotenv.2022.153411
  26. Turk J Anaesthesiol Reanim. 2021 Oct;49(5): 379-388
       AIM: The aim of this study was to investigate the publication status, research design, subjects and levels of evidence of theses written in the field of anaesthesiology and reanimation between 1970 and 2016 in Turkey.
    METHODS: After the theses included in our study were accessed through the Higher Education Institution National Thesis Center, theses were searched using Google, Google Scholar, PubMed, and TR Directory TU¨ B_ITAK ULAKB_IM search engines. The publication status, research design, evidence levels, date of the published theses, journals and citation numbers for the theses were determined.
    RESULTS: A total of 2,803 theses were included in our study. When the evidence levels of the theses are evaluated, it was determined that B evidence level was present in 1,603 (57.2%), C in 597 (21.3%), F in 256 (12.3%) and D in 257 (9.2%). It was also determined that 719 (25.7%) of the theses were published later. The time difference between the thesis and the publication year was 3.14 6 2.26 years. Of these publications, 367 (51.0%) were appeared in national journals, with 293 in SCI-E (40.8%), 25 in SCI (3.5%) and 34 in other foreign journals (4.7%). While the rate of thesis studies with a prospective design decreased over the years, it was determined that experimental and retrospective thesis studies increased (P < .05). In the correlation analysis, there were weak correlations among the publication year, the number of citations and the impact of the journal. There was a positive correlation between the publication year and the number of cases.
    CONCLUSION: Although the number of prospectively designed theses and clinical theses in the field of anaesthesiology and reanimation has decreased over the years, there is an increase in the number of theses converted to publications. Although the rate of publication of theses abroad and in SCI-E journals has increased, decreases in the thesis rate published in SCI journals over the years and in the impact factors of the journals are notable. In the future, studies in anaesthesiology and reanimation should be performed to increase the number of theses that can be published in journals with higher impact.
    DOI:  https://doi.org/10.5152/TJAR.2021.880
  27. Psychother Psychosom Med Psychol. 2022 Feb 03.
      ZIEL: Erste Hypothesen zur wissenschaftlichen Rezeption von psychotherapeutischer Literatur aus der DDR und der Sowjetunion in einem Psychotherapieliteratur-Korpus der BRD (Praxis der Psychotherapie und Psychosomatik 1979-1990) sollten geprüft werden. Außerdem sollten inhaltliche Schwerpunkte der identifizierten wissenschaftlichen Communities verglichen werden.
    METHODIK: Es wurde eine bibliometrische und netzwerkanalytische Untersuchung von Zitationsbeziehungen sowie eine qualitative Inhaltsanalyse der Rezeption von DDR-Literatur und der thematischen Schwerpunkte der identifizierten wissenschaftlichen Communities in Literaturkorpora aus Ost und West durchgeführt.
    ERGEBNISSE: Psychotherapeutische Literatur der DDR wird im untersuchten BRD-Korpus kaum zitiert. Inhaltlich wird diese Literatur nicht tiefergehend in die wissenschaftliche Argumentation des BRD-Korpus eingebunden. Die bekanntesten Vertreter*innen der DDR-Psychotherapie(-forschung) werden im BRD-Korpus gar nicht zitiert. Es lassen sich thematische Überschneidungen in beiden Korpora identifizieren, allerdings spielen DDR-spezifische Themen inhaltlich keine Rolle im BRD-Korpus.
    OBJECTIVE: The aim this study was to test first hypotheses on the scientific reception of literature on psychotherapy from the GDR and the Soviet Union in a corpus of psychotherapy literature from the FRG and to compare content-related foci of the identified scientific communities.
    METHODS: A bibliometric and network analysis of citation relations as well as a qualitative content analysis of the reception of GDR literature and the thematic foci of the identified scientific communities in both literature corpora were conducted.
    RESULTS: Psychotherapeutic literature of the GDR was barely cited in the examined FRG corpus. In terms of content, this literature was not integrated more deeply into the scientific argumentation of the FRG corpus. The best-known representatives of GDR psychotherapy (research) were not at all cited in the FRG corpus. Thematic overlaps could be identified in both corpora, but GDR-specific topics did not play a role in the FRG corpus.
    CONCLUSION: For the examined literature corpora it can be seen that publications from the GDR and Soviet Union are cited considerably less often in FRG literature than publications from the West in GDR literature. Thematically, original GDR psychotherapy content does not play a role in FRG literature either.
    DOI:  https://doi.org/10.1055/a-1718-4071
  28. Dermatol Ther (Heidelb). 2022 Feb 03.
       INTRODUCTION: Most skin disorders, such as atopic dermatitis, psoriasis, skin cancer or age-related skin issues, are the result of a complex interaction between genetic and environmental factors over time. As an external organ, the skin provides the opportunity to study the link between exposure to the environment and several specific biological responses using an exposome approach. The aim of this review was to identify the state of the art of exposome approaches and elucidate the impact of the new era of exposomics on dermatology.
    METHODS: Two parallel and independent bibliometric analyses were conducted based on documents extracted from the Core Collection and the Science Citation Index Expanded (SCI-Expanded) databases from the Clarivate Analytics' Web of Science (WOS) platform by using the following search terms "exposome" and "skin exposome". In both searches, we used the topic field that includes title, abstract, author keywords and keywords plus terms and the following filters: "English language" and all documents published up to 30 September 2021. We further analysed and interpreted documents extracted in plain text format.
    RESULTS: Based on the defined searches, 910 documents were identified as being related to "exposome" and 45 as being related to "skin exposome". Environmental sciences and toxicology were the most impacted research areas, and aging, cancer and respiratory allergies were the most documented diseases while, surprisingly, dermatology was much less impacted. Krutmann et al. were the pioneers in implementing this new concept in dermatology with publication of "The skin aging exposome" in 2017 (J Dermatol Sci. 2017;85:152-61). After this tipping point, the number of publications in dermatology evaluating the impact of exposome factors in many skin disorders has steadily increased.
    CONCLUSIONS: Exposome studies are rapidly attracting interest in dermatology. The results of these studies will undoubtedly improve our understanding of why and under which circumstances some individuals develop skin disorders and help design tailored prevention strategies for patients suffering from these disorders.
    Keywords:  Bibliometric analysis; Dermatology; Environmental factors; Epidemiology; Exposome; Exposure; Omics; Skin
    DOI:  https://doi.org/10.1007/s13555-021-00680-z
  29. J Racial Ethn Health Disparities. 2022 Feb 01.
      Little is known about racial differences in the incidence of light chain (AL) amyloidosis despite the well-documented racial disparities in the epidemiology of other plasma cell disorders. The goal of this study was to examine the extent to which published clinical research in AL amyloidosis report information on patients' race. Clinical research publications in AL amyloidosis between January 1, 2010, and December 31, 2020, from the USA were identified. In addition to the reporting of race, study design, funding, cohort size, year of publication, impact factor of publication journal, and first author degree were abstracted. Among papers reporting race, we also assessed whether ethnicity was reported separately. A PubMed search yielded 2,770 papers of which 220 met the pre-specified criteria for analysis. Of those, 37 (16.5%) reported race. Single institution publications, those with physicians as first authors, and those published in journals with impact factor 6 or higher were less likely to report race. On multivariate analysis, only single institution studies were negatively associated with race reporting. Of the 37 papers reporting race, none defined it in methods, 16% stated how race was identified, and 19% discussed its significance. Ethnicity was reported in 6 studies. Our results indicate that race/ethnicity is underreported in USA. AL amyloidosis clinical literature leads to a challenge for identifying potential racial/ethnic disparities. Standards for collecting and reporting racial/ethnic demographics are needed. Clear and consistent reporting of race and ethnicity of clinical populations is a necessary first step in identifying disparities and promoting equitable care.
    DOI:  https://doi.org/10.1007/s40615-022-01252-3
  30. World J Mens Health. 2022 Jan 25.
       PURPOSE: This study provides a comprehensive analysis of research trends on the etiology, mechanisms, potential risk factors, diagnosis, prognosis, surgical and non-surgical treatment of varicocele, and clinical outcomes before and after varicocele repair.
    MATERIALS AND METHODS: Varicocele studies published between 1988 and 2020 were retrieved from the Scopus database on April 5, 2021. Original studies on human varicocele were included, irrespective of language. Retrieved articles were manually screened for inclusion in various sub-categories. Bibliometric data was subjected to scientometric analysis using descriptive statistics. Network, heat and geographic mapping were generated using relevant software.
    RESULTS: In total, 1,943 original human studies on varicocele were published. These were predominantly from the northern hemisphere and developed countries, and published in journals from the United States and Germany. Network map analysis for countries showed several interconnected nodal points, with the USA being the largest, and Agarwal A. from Cleveland Clinic, USA, being a center point of worldwide varicocele research collaborations. Studies of adolescents were underrepresented compared with studies of adults. Studies on diagnostic and prognostic aspects of varicocele were more numerous than studies on varicocele prevalence, mechanistic studies and studies focusing on etiological and risk factors. Varicocele surgery was more investigated than non-surgical approaches. To evaluate the impact of varicocele and its treatment, researchers mainly analyzed basic semen parameters, although markers of seminal oxidative stress are being increasingly investigated in the last decade, while reproductive outcomes such as live birth rate were under-reported in the literature.
    CONCLUSIONS: This study analyzes the publication trends in original research on human varicocele spanning over the last three decades. Our analysis emphasizes areas for further exploration to better understand varicocele's impact on men's health and male fertility.
    Keywords:  Analysis, bibliometric; Clinical research; Infertility, male; Publications; Varicocele; Varicocele repair
    DOI:  https://doi.org/10.5534/wjmh.210202
  31. Foot Ankle Orthop. 2020 Jul;5(3): 2473011420931419
       Background: As the movement toward evidence-based medicine grows and publication rates rise each year, critical analysis of the orthopedic literature has become increasingly important. To aid readers in assessing the scientific quality of published research, Foot & Ankle International (FAI) began assigning levels of evidence to all clinical articles in 2008. The purpose of this study was to analyze trends in the characteristics and levels of evidence of articles published in FAI between 2000 and 2015.
    Methods: All articles published in FAI from the years 2000, 2005, 2010, and 2015 were reviewed and categorized into article type (clinical, basic science, review, or technical tip). Each clinical article was assigned a level of evidence (I-V) and study type (prognostic, therapeutic, economic, or diagnostic). Descriptive information was gathered pertaining to country of origin, author credentials, and funding. Statistical analysis was performed using chi-squared tests to detect any trends in levels of evidence and publication characteristics.
    Results: A total of 647 articles were reviewed. From 2000 to 2015, there was a statistically significant increase in the publication of clinical research articles (70% to 83%; P = .013), while the number of basic science articles decreased (29% to 17%; P = .013). Of the clinical articles, there was a significant increase in therapeutic studies (41% to 58%; P = .003). During the study period, the publication of Level I and II evidence significantly increased (2% to 14%; P = .002). Although Level III and V evidence also increased (65% to 71%, P > .99), this was not found to be statistically significant. Publications originated from a total of 39 countries, with a significant increase in the proportion of international papers (33% to 48%; P = .007) over the study period. The proportion of articles authored by Doctors of Podiatric Medicine (DPMs) during the study period significantly decreased (4% to 2%, P = .035). Finally, the percentage of studies that disclosed the use of outside funding increased during the study period, with reported funding from grants or professional groups rising from 3% to 16% (P < .001) and reported funding from commercial sources rising from 0% to 9% (P = .002).
    Conclusion: The proportion of Level I and II studies published in FAI significantly increased from 2000 to 2015. The publication of clinical research rose, with a majority being therapeutic studies. There was a significant increase in articles published by international authors and a significant decrease in articles published by DPMs. During the same time period, there was a rise in the proportion of articles reporting the use of outside funding, both professional and commercial.
    Keywords:  Foot & Ankle International; clinical research; level of evidence; publication trends
    DOI:  https://doi.org/10.1177/2473011420931419
  32. Angle Orthod. 2022 Jan 31.
       OBJECTIVES: To map the statistical methods applied to assess reliability in orthodontic publications and to identify possible trends over time.
    MATERIALS AND METHODS: Original research articles published in 2009 and 2019 in a subset of orthodontic journals were downloaded. Publication characteristics, including publication year, number of authors, single vs multicenter study, geographic origin of the study, statistician involvement, study category, subject category, types of reliability assessment, and statistical methods applied to assess reliability, were recorded. Descriptive statistics, Chi-square tests, and logistic regression analyses were performed to investigate associations between reliability analysis and study characteristics.
    RESULTS: A total of 768 original research articles were analyzed. The most prevalent study category was observational (69%) with a statistician involved in 16% of studies. Overall, reliability was assessed in 47% of studies, and the most frequent methods applied to assess reliability were intraclass correlation coefficients or kappa statistics (60.4%). The odds of applying appropriate methods were greater in 2019 than in 2009 (odds ratio [OR]: 2.43; 95% confidence interval [CI]: 1.75, 3.37; P < .001). Involvement of a statistician resulted in greater odds of applying appropriate methods compared to no statistician involvement (OR: 1.88; 95% CI: 1.23, 2.87; P < .01).
    CONCLUSIONS: Over the past decade (2009 vs 2019), reliability assessment became more common in the orthodontic literature, and studies applying correct statistical methods to assess reliability significantly increased. This trend was more apparent in studies that involved a statistician, which may highlight the role of the statistician.
    Keywords:  Reliability statistics; Research trend
    DOI:  https://doi.org/10.2319/081021-625.1
  33. Int J STEM Educ. 2022 ;9(1): 9
       Background: The Moodle Learning Management System (LMS) is widely used in online teaching and learning, especially in STEM education. However, educational research on using Moodle is scattered throughout the literature. Therefore, this review aims to summarise this research to assist three sets of stakeholders-educators, researchers, and software developers. It identifies: (a) how and where Moodle has been adopted; (b) what the concerns, trends, and gaps are to lead future research and software development; and (c) innovative and effective methods for improving online teaching and learning.The review used the 4-step PRISMA-P process to identify 155 suitable journal articles from 104 journals in 55 countries published from January 2015 to June 2021. The database search was conducted with Scopus and Web of Science. Insights into the educational use of Moodle were determined through bibliometric analysis with Vosviewer outputs and thematic analysis.
    Results: This review shows that Moodle is mainly used within University STEM disciplines and effectively improves student performance, satisfaction, and engagement. Moodle is increasingly being used as a platform for adaptive and collaborative learning and used to improve online assessments. The use of Moodle is developing rapidly to address academic integrity, ethics, and security issues to enhance speed and navigation, and incorporate artificial intelligence.
    Conclusion: More qualitative research is required on the use of Moodle, particularly investigating educators' perspectives. Further research is also needed on the use of Moodle in non-STEM and non-tertiary disciplines. Further studies need to incorporate educational theories when designing courses using the Moodle platform.
    Keywords:  Education; Learning management systems; Moodle; Thematic analysis; e-learning
    DOI:  https://doi.org/10.1186/s40594-021-00323-x
  34. ANZ J Surg. 2022 Feb 04.
       BACKGROUND: Presentations at scientific conferences are an important method of research dissemination, with abstracts often used to inform clinical practice. Abstract to publication ratio is a commonly used tool for determining meeting quality. The aim of this study was to determine the publication rate for abstracts presented at the Australian Orthopaedic Association Annual Scientific Meeting (AOA ASM) between 2012 and 2015 inclusive and identify reasons for non-publication.
    METHODS: MEDLINE, PubMed and Google Scholar were searched to determine whether each abstract presented at AOA ASMs between 2012 and 2015 was associated with a full text publication in a peer-reviewed journal. Where a publication could not be located, the presenter was contacted to confirm the reason for non-publication.
    RESULTS: A total of 1130 abstracts were submitted (951 oral and 179 posters), and 573 resulted in full-text peer-reviewed publications (51%). The majority of publications (73%) were published within 2 years of presentation. There was no difference in likelihood of publication for oral presentations compared to posters, nor in the rate of publication across the 4 years of meetings. Common reasons for non-publication were lack of time (32%), publication considered low priority (27%) and journal rejections (22%).
    CONCLUSION: The overall publication rate for abstracts presented at the AOA ASM is 51%, which is an increase from the 1998 ASM (31%). This publication rate is higher than many similar Australian meetings and on par with other international orthopaedic and subspecialty meetings. Future research should investigate potential publication bias and methods to minimise barriers to publication.
    Keywords:  Australian Orthopaedic Association; abstract; orthopaedic surgery; publication; scientific meetings
    DOI:  https://doi.org/10.1111/ans.17516
  35. Stereotact Funct Neurosurg. 2022 Feb 01. 1-14
       BACKGROUND: Deep brain stimulation (DBS) is a neuromodulatory technique that delivers adjustable electrical stimuli to brain targets to relieve symptoms associated with dysregulated neural circuitry. Over the last several decades, DBS has been applied to a number of conditions, including motor, pain, mood, and cognitive disorders. An assessment of the body of work in this field is warranted to determine where we have been, define the current state of the field, and chart a path toward the future.
    OBJECTIVE: The aim of the study was to assess the state of DBS-related research by analyzing the DBS literature as well as active studies sponsored by the National Institutes of Health (NIH) or German Research Foundation (Deutsche Forschungsgemeinschaft [DFG]).
    METHODS: Peer-reviewed DBS publications were extracted from PubMed. Active NIH-funded DBS projects were extracted from the RePORT database and active DFG projects from the German Research Foundation database. Records were analyzed using custom-developed algorithms to generate a detailed overview of past and present DBS-related research. Specifically, records were categorized by publication year, journal, language, country of origin, contributing authors, disorder, brain target, study design, and topic. Expected project duration and costs were also provided for active studies.
    RESULTS: In total, 8,974 publications, 172 active NIH-funded projects, and 34 active DFG projects were identified. Records spanned 52 different disorders across 31 distinct brain targets and showed a recent shift toward studies examining conditions other than movement disorders. Most published works involved human research (80.6% of published studies), of which 10.2% were identified as clinical trials. Increasingly, studies focused on imaging or electrophysiological changes associated with DBS (69.8% NIH-active and 70.6% DFG-active vs. 25.8% published) or developing new stimulation techniques and adaptive technologies (37.8% NIH-active and 17.6% DFG-active vs. 6.5% published).
    CONCLUSIONS: This overview of past and present DBS-related studies provides insight into the status of DBS research and what we can anticipate in the future concerning new indications, improved/novel target selection and stimulation paradigms, closed-loop technology, and a better understanding of the mechanisms of action of DBS.
    Keywords:  Cognitive disorders; Deep brain stimulation; Movement disorders; Psychiatric disorders; Trends
    DOI:  https://doi.org/10.1159/000521372
  36. Acad Emerg Med. 2022 Feb 02.
    2018-2019, 2019-2020 Society for Academic Emergency Medicine Grants
       OBJECTIVES: The objective was to measure the impact of the Society for Academic Emergency Medicine Foundation's (SAEMF) Research Training Grant (RTG) by comparing academic success in grant recipients versus non-recipient applicants. Our primary outcome was subsequent federal funding as a principal investigator (PI) or multiple principal investigator (MPI). Our secondary outcomes included subsequent K-award funding, R-series funding, R01 funding, and academic productivity measured by first author peer-reviewed publications.
    METHODS: The authors examined all SAEMF RTG applicants from 2002 through 2019 (n=109). Data were collected using the National Institutes of Health RePORTER database, a literature search using PubMed, and an online survey sent to all RTG applicants. Relative risks (RRs) with 95% confidence intervals (95% CI) were calculated.
    RESULTS: Over 18 years, 18 of 109 (16.5%) RTG applicants were awarded by SAEMF. Subsequent federal funding as PI or MPI was obtained by 11 of the 18 RTG recipients compared to 29 of the 91 nonrecipients (61% vs. 33%, RR = 1.9; 95% CI = 1.2 to 3.1). The RTG award was also associated with increased probability of receiving a federal Career Development Award (K-series) (RR 2.0; 95% CI 1.1 - 3.9) and R-series award (RR 2.0; 95% CI 1.1 - 3.9) but not an R01 award (RR 2.1; 95% CI 0.8 - 5.3). The median number of first-authored peer reviewed manuscripts did not differ between RTG award recipients (14, IQR 8,44) and nonrecipients (14, IQR 6,30) (p=0.5) though RTG recipients had a higher percentage of their publications as a first author (49% vs 33%, p=0.04).
    CONCLUSIONS: SAEMF RTG awards were associated with increased probability of future federal funding, including career development awards and R-series awards but not R01 awards. RTG recipients also had a higher percentage of their peer reviewed publications as first author.
    DOI:  https://doi.org/10.1111/acem.14456
  37. Scientometrics. 2022 Jan 27. 1-16
      The massive shock of the COVID-19 pandemic has already shown its negative effects on economies around the world, unprecedented in recent history. COVID-19 infections and containment measures caused a general slowdown in research and new knowledge production. Because of the link between R&D output and economic growth, it is to be expected then that a slowdown in research activities will slow in turn the global recovery from the pandemic. Many recent studies also claim an uneven impact on scientific production across gender. In this paper, we investigate the phenomenon across countries, analysing preprint depositions in main repositories. Differently from other works, that compare the number of preprint depositions before and after the pandemic outbreak, we analyse the depositions trends across geographical areas, and contrast after-pandemic outbreak depositions with expected ones. Differently from common belief and initial evidence, the decrease in research output is not more severe for women than for men.
    Keywords:  Lockdown effect; Preprint depositions; Research production; Time series analysis; bioRxiv
    DOI:  https://doi.org/10.1007/s11192-021-04245-x
  38. Front Chem. 2021 ;9 818461
      Tea is a popular beverage all around the world. Tea composition, quality monitoring, and tea identification have all been the subject of extensive research due to concerns about the nutritional value and safety of tea intake. In the last 2 decades, research into tea employing electrochemical biosensing technologies has received a lot of interest. Despite the fact that electrochemical biosensing is not yet the most widely utilized approach for tea analysis, it has emerged as a promising technology due to its high sensitivity, speed, and low cost. Through bibliometric analysis, we give a systematic survey of the literature on electrochemical analysis of tea from 1994 to 2021 in this study. Electrochemical analysis in the study of tea can be split into three distinct stages, according to the bibliometric analysis. After chromatographic separation of materials, electrochemical techniques were initially used only as a detection tool. Many key components of tea, including as tea polyphenols, gallic acid, caffeic acid, and others, have electrochemical activity, and their electrochemical behavior is being investigated. High-performance electrochemical sensors have steadily become a hot research issue as materials science, particularly nanomaterials, and has progressed. This review not only highlights these processes, but also analyzes and contrasts the relevant literature. This evaluation also provides future views in this area based on the bibliometric findings.
    Keywords:  analytical chemistry; antioxidant; caffeic acid; electrochemical sensor; gallic acid; tea; tea polyphenols
    DOI:  https://doi.org/10.3389/fchem.2021.818461
  39. J Med Internet Res. 2022 Feb 01. 24(2): e32309
       BACKGROUND: Being diagnosed with cancer during childhood or adolescence can disrupt important periods in an individual's physical, psychosocial, and spiritual development and potentially reduce the quality of life (QOL) after treatment. Research is urgently required to improve the QOL for child and adolescent cancer survivors, and it is necessary to analyze the trends in prior research reported in international academic journals to identify knowledge structures.
    OBJECTIVE: This study aims to identify the main keywords based on network centrality, subgroups (clusters) of keyword networks by using a cohesion analysis method, and the main theme of child and adolescent cancer survivor-related research abstracts through topic modeling. This study also aims to label the subgroups by comparing the results of the cohesion and topic modeling.
    METHODS: A text network analysis method and topic modeling were used to explore the main trends in child and adolescent cancer survivor research by structuring a network of keyword (semantic morphemes) co-occurrence in the abstracts of articles published in 5 major web-based databases from 2016 to 2020. A total of 1677 child and adolescent cancer survivor-related studies were used for data analyses. Data selection, processing, and analyses were also conducted.
    RESULTS: The top 5 keywords in terms of degree and eigenvector centrality were risk, control interval, radiation, childhood cancer treatment, and diagnosis. Of the 1677 studies used for data analyses, cluster 1 included 780 (46.51%) documents under risk management, cluster 2 contained 557 (33.21%) articles under health-related QOL and supportive care, and cluster 3 consisted of 340 (20.27%) studies under cancer treatment and complications.
    CONCLUSIONS: This study is significant in that it confirms the knowledge structure based on the main keywords and cross-disciplinary trends in child and adolescent cancer survivor research published in the last 5 years worldwide. The primary goal of child and adolescent cancer survivor research is to prevent and manage the various aspects of the problems encountered during the transition to a normal life and to improve the overall QOL. To this end, it is necessary to further revitalize the study of the multidisciplinary team approach for the promotion of age-specific health behaviors and the development of intervention strategies with increased feasibility for child and adolescent cancer survivors.
    Keywords:  adolescent; cancer survivors; child; knowledge structures; research trends; text network analysis; topic modeling
    DOI:  https://doi.org/10.2196/32309
  40. Foot Ankle Orthop. 2021 Jul;6(3): 24730114211033299
       Background: No study in the orthopedic literature has analyzed the demographic characteristics or surgical training of foot and ankle fellowship directors (FDs). Our group sought to illustrate demographic trends among foot and ankle fellowship leaders.
    Methods: The American Orthopaedic Foot & Ankle Society (AOFAS) Fellowship Directory for the 2021 to 2022 program year was queried in order to identify all foot and ankle fellowship leaders at programs currently offering positions in the United States and Canada. Data points gathered included age, sex, race/ethnicity, location of surgical training, time since training completion until FD appointment, length in FD role, and individual research H-index.
    Results: We identified 68 fellowship leaders, which consisted of 48 FDs and 19 co-FDs. Sixty-five individuals (95.6%) were male, and 3 (4.4%) were female. As regards race/ethnicity, 88.2% of the leadership was Caucasian (n = 60), 7.4% was Asian American (n = 5), 1.5% was Hispanic/Latino (n = 1), and 1.5% was African American (n = 1). The average age was 51.5 years, and the calculated mean Scopus H-index was 15.28. The mean duration from fellowship training to fellowship leader position was 11.23 years.
    Conclusion: Leaders within foot and ankle orthopedic surgery are characterized by research prowess and experience, but demographic diversity is lacking.
    Level of Evidence: Level III.
    Keywords:  diversity; foot and ankle fellowship; medical education; orthopedic fellowship; orthopedic leadership; orthopedic surgery
    DOI:  https://doi.org/10.1177/24730114211033299
  41. Am J Emerg Med. 2022 Jan 24. pii: S0735-6757(22)00040-7. [Epub ahead of print]54 17-21
       BACKGROUND: Studies show that although the presence of women in the medical field has risen, there is a lesser representation of women within editorial boards of journals. Studies on this subject have mostly been carried out related to the medical field of the researcher. It is not known what position the emergency medicine department is in this regard compared to other departments. We aimed to investigate whether gender disparity exists within the editors and editorial board members of medical journals, especially in those related to emergency medicine.
    METHODS: In the present cross-sectional study, we searched medical journals using the Scimago Journal/Country Rank journal system for comparison. The websites of the journals included in the study were searched, and gender data of the editor and editorial board, associate editors, consultant editors, and section editors for each journal were obtained.
    RESULTS: The total number of journals examined in this study was 276. The median percentage of female editorial board members (20.8%; 50-100) was lower in emergency medicine journals compared to other branches of medicine (31%; 0-100) (p < .001). The median percentage of female editorial board members and editors was also lower in the emergency medicine field (20.6%; 0-50) (p < .001) than in other branches of medicine. The percentage of female editorial board members of emergency medicine journals was 19.5% with the third-lowest ranking among 26 branches. When both the editors and editorial board members were considered, the highest female percentage was found in pediatrics (50.7%) followed by geriatric medicine (43.4%).
    CONCLUSION: There is a significant gender disparity within editors and editorial board members in emergency medicine journals. The proportion of women within the editorial board was found to be lower in emergency medicine journals among all the journals included in the study.
    Keywords:  Editorial; Emergency medicine; Female; Male; Medicine
    DOI:  https://doi.org/10.1016/j.ajem.2022.01.040