Trends Endocrinol Metab. 2025 Aug 12. pii: S1043-2760(25)00152-3. [Epub ahead of print]
Central nervous system (CNS) myelin may act as a dynamic energy store that supports brain metabolism; its consumption and replenishment is a newly recognized form of metabolic plasticity aimed at maintaining brain function upon limited glucose supply. In this forum article we propose that myelin dysfunctions may affect human health in aging and neurodegenerative diseases.
Keywords: aging; energy metabolism; myelin; neurodegenerative diseases