bims-cliped Biomed News
on Clinical pediatrics
Issue of 2026–10–11
25 papers selected by
Alyssa M. Portwood, Akron’s Children



  1. Pediatrics. 2026 Oct 06. pii: e2026075956. [Epub ahead of print]
      
    OBJECTIVES: To develop an Achievable Benchmarks of Care (ABCs) report card for common conditions managed by pediatric hospital medicine (PHM).
    METHODS: We performed a retrospective cross-sectional study of encounters for 13 common pediatric conditions between January 1, 2023, and December 31, 2024, using the Pediatric Health Information System database. Conditions included bronchiolitis, asthma, pneumonia, urinary tract infection, constipation, gastroenteritis, cervical lymphadenitis, skin and soft tissue infection, orbital cellulitis, osteomyelitis, septic arthritis, neonatal fever, and simple febrile seizure. Overall utilization measures included length of stay (LOS) and readmission rate. Condition-specific measures included imaging, laboratory testing, procedures, and medications ordered. ABCs were calculated using top-performing hospitals (≥10% of each cohort). For each measure, we calculated the median hospital performance, IQR, ABCs, and performance gap (difference between median performance and the ABC).
    RESULTS: We compiled 115 measures for the 13 conditions, representing 237 283 hospitalizations or 33.5% of nonsurgical discharges among children meeting our overall inclusion/exclusion criteria. For 11 conditions, calculated ABCs for LOS were less than 48 hours. The ABC LOS for the remaining 2 conditions (osteomyelitis and septic arthritis) was less than 74 hours; these 2 conditions experienced the greatest performance gap. ABC readmission rates across all conditions were less than 2.0%. As an example of a condition-specific measure, we assessed chest radiograph performance across respiratory conditions with ABCs ranging from 20.6% to 57.9%, associated with a performance gap of 18.3% to 22.4%.
    CONCLUSIONS: We developed a core set of PHM-specific ABCs and incorporated them into designed to support local and collaborative multicenter improvement efforts.
    DOI:  https://doi.org/10.1542/peds.2026-075956
  2. Pediatrics. 2026 Oct 06. pii: e2026076448. [Epub ahead of print]
      More effective and less toxic therapies are welcomed by clinicians and families and are the rationale and raison d'être for well-designed clinical trials. This is especially true for life-threatening diseases like childhood cancer. When parents opt for an existing and good treatment, rather than accept a new and better treatment of a child with cancer, clinicians may struggle to accept the parents' refusal. In considering such a refusal, should parental reasons matter? In this situation, should clinicians be more forceful in attempting to sway the parents to accept a novel and improved therapy? How does the sincerity of the therapeutic relationship, especially trust, factor into this calculus? In the following ethics rounds, stemming from a 2025 American Society for Bioethics and Humanities Meeting session, the commentators draw on their diverse background as pediatric clinicians, bioethicists, philosophers, and educators to navigate this challenging situation. They consider the intersection of evolving standards of care, parental authority, and clinician influence, with particular attention to communication and trust, emphasizing active listening and attending to what parents have to say.
    DOI:  https://doi.org/10.1542/peds.2026-076448
  3. Acad Pediatr. 2026 Oct 07. pii: S1876-2859(26)00248-2. [Epub ahead of print] 103466
       INTRODUCTION: Pediatric readiness is associated with improved quality of care and has known geographic variation. Less is known about disparities in patient access to hospital pediatric capabilities. Our goal was to examine associations between patient race / ethnicity and pediatric capability of the initial hospital presentation.
    METHODS: We linked state data, combining 2019 National Emergency Department Inventory (NEDI)-USA, 2019 State Emergency Department and State Inpatient Databases (SEDD/SID), 2020 Supplemental NEDI Pediatric Emergency Care Coordinator (PECC) Survey, and the 2021 National Pediatric Readiness Program (NPRP) Survey. Primary exposure was race / ethnicity. We compared pediatric capability definitions and used logistic regressions to examine associations between race / ethnicity and pediatric capability adjusting for select covariates.
    RESULTS: There were 2,281,885 ED visits in the NPRP cohort, 4,426,520 in the PECC cohort and 4,964,956 in the inpatient capability cohort. In unadjusted analyses, non-Hispanic Black and Hispanic patients had higher odds of presenting to hospitals with high NPRP scores (OR 2.02 [95% CI 1.44, 2.84] and OR 1.94 [95% CI 1.09, 3.46]), with a PECC (OR 2.30 [1.83, 2.88] and OR 3.14 [2.32, 4.26]), and with inpatient capability (2.03 [1.64, 2.51] and 2.08 [1.54, 2.81]). After adjustment, non-Hispanic Black patients had higher odds of presenting to hospitals with inpatient capability (1.47 [1.13-1.92]); in contrast Hispanic patients had higher odds of presenting to hospitals with a PECC (1.48 [1.11-1.98]).
    CONCLUSION: Non-Hispanic Black and Hispanic children were more likely to present to a hospital with a PECC, suggesting utilization of PECCs may reduce disparities in care.
    DOI:  https://doi.org/10.1016/j.acap.2026.103466
  4. JAACAP Open. 2026 Oct;4(5): 823-832
       Objective: To examine national trends in suicidality-related (intentional self-harm, self-inflicted injury, and suicide attempt) emergency department (ED) visits among US children and adolescents between 2016 and 2022 and describe demographic and psychiatric correlates across age groups.
    Method: Data were obtained from the 2016 to 2022 Nationwide Emergency Department Sample (NEDS) for patients aged 5 to 19 years with suicidality-related ICD-10-CM codes. Weighted national estimates, demographics, and psychiatric comorbidities were compared across age groups (5-9, 10-14, and 15-19 years). Temporal trends were evaluated using Daniel's test for trend, with p < .05 considered significant.
    Results: There were an estimated 1,100,785 suicidality-related ED visits (intentional self-harm 61%, self-inflicted injury 39%, suicide attempt 9%). The number of visits increased significantly among age group 10 to 14 for all diagnoses (p ≤ .01) and among age group 15 to 19 for suicide attempts only (p = .003). Female patients (74.7%) accounted for most visits. Depression (45.3%) and anxiety (21.6%) were the most common comorbidities.
    Conclusion: Suicidality-related ED visits among US youth remain alarmingly high, especially among young adolescents. The predominance of depression, anxiety, and female patient representation underscores the need for early, community-based mental health interventions and post-ED follow-up care.
    Clinical guidance: • Screen earlier and repeatedly. Incorporate routine suicide risk screening beginning in late elementary school (ages 9-10), especially during well-child visits, school physicals, and emergency department encounters, even when presenting complaints are nonpsychiatric.• Treat self-harm as a high-risk signal. Any self-inflicted injury-regardless of stated intent-should trigger a structured suicide risk assessment, safety planning, and close follow-up, as self-harm often precedes suicide attempts.• Address comorbid depression, anxiety, and trauma aggressively. Early identification and evidence-based treatment (eg, cognitive behavioral therapy, dialectical behavior therapy-informed skills, trauma-focused care) should be prioritized, with coordinated family involvement when developmentally appropriate.• Strengthen transitions of care after emergency department visits. Ensure rapid outpatient follow-up (within 7 days), clear communication with caregivers, and linkage to school- and community-based supports, particularly for preteens and adolescents from low-income households.
    Diversity & Inclusion Statement: One or more of the authors of this paper self-identifies as a member of one or more historically underrepresented racial and/or ethnic groups in science. We actively worked to promote sex and gender balance in our author group. We actively worked to promote inclusion of historically underrepresented racial and/or ethnic groups in science in our author group. The author list of this paper includes contributors from the location and/or community where the research was conducted who participated in the data collection, design, analysis, and/or interpretation of the work.
    Keywords:  ICD-10; adolescent mental health; emergency department utilization; pediatric suicidality; suicide attempts and self-harm
    DOI:  https://doi.org/10.1016/j.jaacop.2026.06.006
  5. Pediatr Emerg Care. 2026 Oct 05.
      The phrase "children are not small adults" has appropriately emphasized the distinct physiological, developmental, pharmacologic, and psychosocial needs of pediatric patients. Yet when educators and health systems convey this message without placing equal emphasis on Pediatric Readiness, they may unintentionally imply that pediatric emergency care is primarily the domain of pediatric specialists. This implication conflicts with the reality that more than 80% of children receive emergency care outside specialized children's hospitals, often in settings where pediatric specialists are not physically present. This Special Feature calls for Pediatric Readiness to be understood as essential infrastructure for every emergency department that cares for children. Rather than diminishing pediatric specialization, we reframe pediatric expertise as a system-level resource that can be extended through education, protocols, simulation, teleconsultation, transfer collaboration, and advocacy. The next imperative in pediatric emergency care is to preserve what is distinct about children while ensuring that every emergency setting can care for them safely, competently, and collaboratively.
    Keywords:  community emergency departments; emergency department preparedness; pediatric emergency care; pediatric emergency medicine; pediatric readiness; systems preparedness
    DOI:  https://doi.org/10.1097/PEC.0000000000003720
  6. Pediatr Emerg Care. 2026 Oct 08.
       OBJECTIVE: Food insecurity (FI) is prevalent in many urban settings across the United States. Many vulnerable families who lack access to a medical home utilize the pediatric emergency department (PED), making the PED a critical access point to address FI. We aimed to understand caregivers' experiences in receiving prepackaged groceries and community resources within a PED.
    METHODS: In this pilot initiative, caregivers who screened positive for FI in the PED received prepackaged groceries for their household and a list of community resources. Caregivers were interviewed to understand their experience in receiving food resources in the PED. Phone interviews were conducted until code saturation was reached. Interviews were recorded, transcribed, and coded. Content analysis generated themes describing the impact of the intervention. This study was conducted in a tertiary care PED in an urban setting between October 2018 and June 2019. Participants included English-speaking caregivers of children younger than 18 years.
    RESULTS: Ninety-six households received groceries and a list of community food resources. Four themes emerged from interviewing 23 caregivers: (1) immediate food relief was helpful when their child was acutely ill, (2) caregivers generally accepted the food from the prepackaged bags, (3) community resources were difficult to access, and (4) FI households who did not use community resources ascribed this to a lack of need for urgent food.
    CONCLUSIONS: Families perceived benefits of being provided groceries during emergency department visits since there are barriers to accessing community resources.
    Keywords:  access to essentials; food access; food insecurity; health related social needs; pediatric emergency department
    DOI:  https://doi.org/10.1097/PEC.0000000000003722
  7. Pediatr Ann. 2026 Oct;55(10): e418-e422
      Human trafficking and exploitation of children are recognized pediatric public health concerns. Children and adolescents who experience trafficking may present to pediatric acute care settings with injuries, sexually transmitted infections, pregnancy concerns, malnutrition, substance use, chronic pain, behavioral health crises, delayed care, or non-specific somatic symptoms. Disclosure is uncommon, and clinical recognition depends on awareness of risk factors, careful observation, trauma-informed communication, and clear response pathways. Pediatric clinicians should avoid relying on stereotypes or expecting patients to self-identify as trafficked. Instead, clinicians can use developmentally appropriate and nonjudgmental questions, ensure privacy when safe, use professional interpreters, and involve multidisciplinary partners. This article provides a practical approach for pediatric clinicians in emergency department, urgent care, hospital, inpatient settings, and outpatient clinics to recognize possible trafficking, communicate safely, avoid common pitfalls, and connect children with appropriate protection and support.
    DOI:  https://doi.org/10.3928/19382359-20260730-04
  8. Expert Rev Clin Pharmacol. 2026 Oct 09. 1-15
       INTRODUCTION: In pediatrics, drugs require specific study in children rather than being prescribed based on data extrapolated from adults. Historically, this requirement was hindered by various challenges, resulting in widespread off-label drug use. The extent of such use has been extensively investigated, and new regulations in the U.S. and Europe came into force.
    AREAS COVERED: We conducted a narrative review addressing the epidemiology, associated risks, and regulatory implications of off-label drug use. This involved performing a targeted PubMed search and synthesizing relevant review articles and policy guidelines. The included studies, despite being informative, showed substantial heterogeneity, limiting the comparability and interpretability of their findings. Particularly, quantitative evidence regarding associated risks remains scarce. In addition to risks to patients, liability represents an important concern. Although regulatory policies vary between countries, the level of supporting evidence and accepted standards of practice are consistently central considerations.
    EXPERT OPINION: Future efforts should therefore focus on using available data to inform individual treatment decisions, ensuring this knowledge is accessible to prescribers, and addressing areas where evidence is particularly limited and patient safety is most compromised. Artificial intelligence and modeling may facilitate evidence generation and improve clinical-trial efficiency. Nevertheless, these approaches should complement, not replace, research conducted directly in pediatric patients.
    Keywords:  Children; off-label; pediatric; prescribing; regulation; risks; unlicensed
    DOI:  https://doi.org/10.1080/17512433.2026.2742318
  9. Int J Pediatr. 2026 ;2026 4549313
       Background: Functional neurological disorder (FND) is a complex, multinetwork brain disorder that is characterized by the presence of a broad range of neurological symptoms in the absence of neurological disease or damage. For pediatric patients requiring an in-patient stay, misdiagnosis, lack of provider consistency and diagnostic education, frequent testing and work-up, and invasive procedures are often reported. This review will characterize the population, identify current state for receiving diagnosis, detect variability in service delivery, and provide information to evaluate use of resources.
    Methods: This retrospective chart review examined electronic medical records (EMRs) of 59 patients at a pediatric teaching hospital who were admitted following a visit to the emergency department. Records were compiled by the rehabilitation department with inclusion criteria as having a documented diagnosis of FND or as having a similar functional movement related diagnosis such as chorea, panic disorder, and psychogenic nonepileptic seizure (PNES). Extracted data included the following: demographics, patient characteristics, admission characteristics and experience, and discharge recommendations.
    Results: Fifty-nine charts were initially reviewed with 57 meeting inclusion criteria. The subjects in this study had a mean age of 13.7 years (SD: 6.33) and 80.7% were female. The most commonly reported psychiatric diagnoses included anxiety (66.7%), ADHD (29.6%), and depression (22.2%). The most commonly reported FND symptoms at admission were weakness (47.4%), gait instability (28.1%), sensory disturbances (26.3%), and tremor (19.1%). Physical therapy consultations were the most frequently performed (66.7%), followed by occupational therapy (52.6%), psychiatry (38.6%), and psychology (5.3%). No interdisciplinary care conferences were performed. The mean length of stay was 5.13 days (SD: 4.45 days). Readmission rate after 30 days was 16.5%.
    Conclusions: This retrospective EMR review identifies opportunities to improve care for pediatric FND, including reducing unnecessary imaging, testing, and readmissions through strengthened provider, patient, and family education. Findings also highlight inconsistent referrals to physical therapy, occupational therapy, and mental health services. Addressing these gaps may enhance patient experience, support more coordinated interdisciplinary care, and reduce healthcare utilization for this under-recognized population.
    Keywords:  functional neurological disorder; neurology; pediatric; psychiatry; quality improvement; rehabilitation
    DOI:  https://doi.org/10.1155/ijpe/4549313
  10. JAMA Pediatr. 2026 Oct 05.
       Importance: Screening tools have been implemented with the goal of improving early detection of pediatric sepsis, with limited evidence of effectiveness. The Epic Systems Pediatric Sepsis Early Detection Model (PESM) and its associated clinical alert have been widely implemented in emergency departments (EDs) in the US but have not undergone independent evaluation.
    Objective: To evaluate the diagnostic characteristics of the Epic PESM for (1) identifying sepsis and (2) identifying sepsis before patients met Phoenix sepsis criteria.
    Design, Setting, and Participants: This retrospective multicenter cohort study of pediatric ED encounters was conducted across 8 EDs within a New York health system from January 2024 through June 2025. Children younger than 18 years were included; behavioral health encounters and ED deaths within 1 hour of arrival were excluded. Data were analyzed from August 2025 through July 2026.
    Exposure: Triggering of the PESM alert in the first 24 hours after ED arrival.
    Main Outcomes and Measures: Sepsis was defined as a Phoenix score of 2 or higher. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated for the outcome of sepsis within 24 hours of ED arrival. Secondarily, evaluation was restricted to only instances in which the alert triggered before sepsis onset. Sensitivity was evaluated in relevant subgroups, and a subgroup with a sensitivity 10% or more below the overall cohort sensitivity was considered clinically meaningful.
    Results: Among 166 943 pediatric ED encounters, 189 cases of sepsis occurred in the first 24 hours. A total of 76 685 pediatric patients (45.9%) were female, and 79 032 patients (47.3%) were under the age of 5 years. Sensitivity of the PESM for identifying patients with sepsis was 36% (95% CI, 29%-43%); PPV was 3% (95% CI, 2%-4%), and NPV was greater than 99% (95% CI, 99%-99%). The alert triggered before sepsis with a sensitivity of 30% (95% CI, 24%-37%). Subgroup sensitivity was 10% or more below overall cohort sensitivity in Black children (22%; 95% CI, 9%-40%) and among children less than 5 years old (20%; 95% CI, 12%-30%), as well as in EDs outside of tertiary children's hospitals (25%; 95% CI, 14%-40%).
    Conclusions and Relevance: Per the results of this multicenter cohort study, the PESM alert had low sensitivity for identifying children with sepsis and does not support timely or equitable pediatric sepsis screening. Sensitivity was low in Black children, in children younger than 5 years, and outside of tertiary children's hospitals.
    DOI:  https://doi.org/10.1001/jamapediatrics.2026.4575
  11. Acad Pediatr. 2026 Oct 07. pii: S1876-2859(26)00225-1. [Epub ahead of print] 103443
       OBJECTIVE: To quantify changes in the rates and demographic distribution of pediatric pedestrian injuries before and after the COVID-19 pandemic.
    METHODS: We used interrupted time series analysis to characterize pre- and post-2020 trends in volume, age, race/ethnicity, day/night timing, and severity of pedestrian injuries among children aged ≤15 seen in academic pediatric emergency departments within the Pediatric Health Information System (2016-2023).
    RESULTS: A total of 19,958 visits for pedestrian injury were identified. Annual volumes fell from a mean of 2,743 (CI 95% = 2,499, 2,988) to 1,789 in 2020, or an estimated 897 fewer than expected (95% CI = 612, 1180), then increased by 259 visits/year (95% CI = 200, 317) to 2,570 by 2023. This pattern was primarily driven by school-aged adolescent children (aged 10-15), whose visit volumes fell from 1,331 in 2016-2019 to 765 in 2020, then rebounded to 1,334 by 2023. The proportion of non-White children fell from 73.4% in 2016-2019 to 66.8% in 2020, then increased by 2.2%/year through 2023 to 72.9%. Daytime presentations similarly fell from 73.7% to 69.6% in 2020, then rebounded to 72.5% by 2023. No pandemic-associated changes were seen in mean Child Opportunity Index or income.
    CONCLUSIONS: The COVID-19 pandemic was associated with large but temporary decreases in overall pediatric pedestrian trauma volumes and percent non-White patients, especially during the day and among school-aged children. These patterns suggest that routine daily traffic exposure may contribute differently to pedestrian risk across age groups and racial/ethnic categories with potential implications for targeted safety interventions.
    Keywords:  Disparities; Injury Prevention; Pedestrian; Trauma
    DOI:  https://doi.org/10.1016/j.acap.2026.103443
  12. Discov Ment Health. 2026 Oct 07. pii: 188. [Epub ahead of print]6(1):
      In recent years, there has been considerable concern about the deterioration of mental health in children and adolescents, and there is a coincidence between mental disorders and addictive disorders. In view of this situation, it is important to review preventive interventions from the educational field, since it is considered an area of socialization par excellence of the subjects that can avoid or reduce exposure to adversities at an early age. For this purpose, a narrative review was carried out. The databases PubMed, PsycINFO and ERIC were searched. A total of 2096 records were retrieved from which 16 studies were selected. Most of the interventions reviewed adopted a universal approach. Most of the articles reviewed refer to interventions around 13-15 years of age and, in general terms, no specific actions are specified by groups according to their needs or risks. The intervention is usually applied by teachers in collaboration with other health experts. The focus is mainly on depression, anxiety, alcohol, cannabis and tobacco, but mental health is also promoted with reinforcement of emotional competence and training in social skills. Also, there is a scarce presence of programs on non-substance addictions and long-term follow-up studies. Based on what has been studied in this research, preventive initiatives are at a point of unquestionable reflection that requires redirecting efforts based on solid scientific evidence that determines approaches adjusted to the realities of the target populations and that helps to make decisions on when to carry out universal or specific interventions.
    Keywords:  Addictions; Children and adolescents; Mental disorders; Narrative review; School-based prevention
    DOI:  https://doi.org/10.1007/s44192-026-00532-2
  13. Pediatr Emerg Care. 2026 Oct 08.
       OBJECTIVES: Describe the population of autistic children who undergo nitrous oxide sedation and the rate of associated adverse events (AEs). Analyze patient- and procedure-level factors associated with AEs in autistic children receiving nitrous oxide outside the dental setting.
    METHODS: A retrospective, descriptive study of autistic children, 3 to 18 years, who received nitrous oxide for procedural sedation during an emergency department or sedation encounter within a single hospital system between January 2014 and December 2023. Data extracted included patient demographics and comorbidities, as well as indication, maximum concentration, duration of administration, and AEs of nitrous oxide. Descriptive statistics were used to summarize the data.
    RESULTS: Analysis was performed on 186 patients [median age: 8 years (interquartile range: 5.2-12.75), 74.2% male]. Intravenous line placement was the most common indication in all locations. Most received 70% nitrous oxide with a median duration of 6 minutes (interquartile range: 4 -9.75). AEs were rare, occurring in only 3 patients (1.6%), with zero vomiting or aborted procedures. Given the rarity of AEs, no associated factors were able to be identified.
    CONCLUSIONS: Nitrous oxide is a safe, effective, and well-tolerated option for procedural sedation in autistic children, with a low rate of AEs. These findings add to the limited literature supporting its use in nondental settings and suggest it may be a valuable tool for facilitating minor procedures in this population. Future prospective studies are needed to optimize nitrous oxide delivery and determine factors contributing to AEs.
    Keywords:  anxiolysis; autism; nitrous oxide; pediatric emergency medicine; pediatric procedural sedation; sedation
    DOI:  https://doi.org/10.1097/PEC.0000000000003726
  14. Curr Med Res Opin. 2026 Oct 04. 1-18
       BACKGROUND: Vomiting is a leading cause of emergency department (ED) visits among children with acute gastroenteritis (AGE). Although antiemetics are commonly used, uncertainty persists regarding the comparative efficacy and safety of individual agents across clinically relevant timeframes.
    OBJECTIVE: To compare the efficacy and safety of commonly used antiemetics for pediatric AGE-related vomiting in ED settings using a network meta-analysis (NMA) of randomized controlled trials (RCTs).
    METHODS: A systematic search of major databases was conducted through 2025. Eligible studies were RCTs enrolling children ≤21 years presenting to the ED with AGE. Interventions included ondansetron (all routes), dimenhydrinate, domperidone, metoclopramide, bromopride, and placebo. Outcomes included vomiting frequency (short-, intermediate-, and long-term), cessation of vomiting, need for intravenous (IV) rehydration, ED length of stay, hospitalization, and adverse events. A random-effects frequentist NMA was performed. Risk of bias was assessed using ROB-2, and certainty of evidence was evaluated with GRADE.
    RESULTS: Thirty-three RCTs were included. In the short term, all ondansetron formulations reduced vomiting compared with placebo, with the strongest effect seen with IV administration (MD -1.86, 95% CI -3.25 to -0.47). For intermediate-term outcomes, IV ondansetron was the only agent consistently superior to placebo and active comparators. For long-term vomiting, dimenhydrinate (oral and rectal) demonstrated significant benefit (rectal: MD -0.72, 95% CI -1.14 to -0.30). Vomiting cessation within 24 h favored IV ondansetron (RR 1.56, 95% CI 1.29-1.89), with additional benefit from rectal dimenhydrinate (RR 1.48, 95% CI 1.08-2.04). Ondansetron reduced the need for IV rehydration (RR 0.62, 95% CI 0.44-0.88) and modestly shortened ED stay. Safety comparisons were imprecise, though ondansetron showed fewer adverse events than metoclopramide.
    CONCLUSIONS: Ondansetron provides the most consistent benefit for acute vomiting control and reducing IV fluid use in pediatric AGE, while dimenhydrinate may support longer-term symptom control.
    Keywords:  Antiemetic; emergency department; emesis; nausea; vomiting
    DOI:  https://doi.org/10.1080/03007995.2026.2734671
  15. Pediatrics. 2026 Oct 08. pii: e2025075231. [Epub ahead of print]
       BACKGROUND AND OBJECTIVE: Transient tachypnea of the newborn (TTN) is a common respiratory disorder affecting late-preterm and term infants. Newborns with TTN are typically admitted to the neonatal intensive care unit (NICU) for medical care. Our objective was to reduce NICU length of stay (LOS) for patients with TTN by standardizing care to limit unnecessary intervention.
    METHODS: We used the Model for Improvement to implement interventions in our level III and IV NICUs and analyzed data using control charts. Interventions included consensus development/data review, clinical practice guideline implementation, case audits, and an electronic medical record (EMR) order set. Infants aged 35 weeks or more with TTN were included. The primary outcome measure was NICU LOS. Secondary outcome measures were time to first feed, time on respiratory support, incidence of peripheral intravenous (PIV) catheter placement, incidence of intravenous fluid (IVF) administration, incidence of hyponatremia, number of blood draws, and percentage of same-day birth parent-baby discharges. Balancing measures included NICU readmissions, percentage of patients with hypoglycemia, and exposure to breast milk during hospitalization.
    RESULTS: LOS decreased (90 to 51 hours) after study interventions. Time to first feed, time on respiratory support, incidence of hyponatremia, PIV placement, and IVF administration also decreased. Percentage of infants discharged home with their birth parent increased. No changes were noted in any balancing measures.
    CONCLUSION: By prioritizing clinical guideline development, case audits, and EMR implementations, this quality-improvement initiative resulted in decreased LOS and reduced medical interventions for infants with TTN admitted to a level III and level IV NICU.
    DOI:  https://doi.org/10.1542/peds.2025-075231
  16. Horm Res Paediatr. 2026 Oct 07. 1
      Rates of type 1 diabetes (T1D) and type 2 diabetes (T2D) in the pediatric population have risen over the past two decades. Insulin therapy remains critical for diabetes management, and proper injection technique has been shown to improve injection experience, glycemic management, and health outcomes. Youth with diabetes (YWD), ranging from infancy to young adulthood, require unique considerations for injection technique and education best practices due to their distinct physiological, developmental, emotional, psychological, and psychosocial needs relative to adults. Considering these needs, comprehensive recommendations addressing both physiological and behavioral health aspects of YWD are warranted. Nine pediatric diabetes specialists from five countries collaborated virtually to develop pediatric and young adult recommendations for proper injection technique updated from the adult-focused Forum for Injection Technique and Therapy Expert Recommendations (FITTER) Forward guidelines published in 2025. The resulting 'FITTER Forward Youth' recommendations address insulin initiation, injection technique, storage, injection method, and lipodystrophy. Psychosocial concerns for YWD and their caregivers, including diabetes distress, depressive symptoms, and anxiety, are also discussed. Additionally, technical and psychosocial education around insulin administration is key for YWD, their primary caregivers, and community-based secondary caregivers through daycare or school. Due to variable resources across geographical regions and socio-economic groups, FITTER Forward Youth also encompasses proper injection technique education for manual injection devices, which are typically more accessible than advanced diabetes technologies, such as insulin pumps and automated insulin delivery systems.
    DOI:  https://doi.org/10.1159/hrp/adaag036
  17. Evid Based Pract Child Adolesc Ment Health. 2026 ;11(2): 283-297
       BACKGROUND: Transgender and gender diverse (TGD) children and adolescents in the United States are currently experiencing an oppressive sociopolitical climate that is likely impacting their mental wellbeing. TGD children, defined as 5- to 10-year-olds, have the capacity to be aware of the anti-trans sociopolitical climate and, within the context of developmental readiness, TGD children and their caregivers may benefit from having conversations about the sociopolitical climate with a mental health provider. However, there are no clinical guidelines for how mental health providers may approach conversations about the anti-trans sociopolitical climate with TGD children and caregivers.
    OBJECTIVE: This article aims to fill this gap by providing tangible and clinically actionable guidance from a team of pediatric/child and adolescent psychologists with extensive clinical experience supporting TGD children in various clinical settings and geographic regions of the United States.
    METHOD: We discuss existing literature on how to talk with children about other forms of oppression, emphasize the importance of a mental health provider being aware of their own emotions regarding the sociopolitical climate, discuss the importance of assessing where the family might be starting at with respect to awareness of and attitudes toward the sociopolitical climate, provide specific clinical guidance on how to talk about the anti-trans sociopolitical climate with children (and model these conversations for caregivers), and then provide specific clinical guidance on approaches to supporting caregivers. Throughout, there are clinical dialogs offering sample language between therapist and child/caregiver.
    CONCLUSION: Future research is indicated to better understand how TGD children understand the anti-trans sociopolitical climate and inform intervention development and implementation focused on facilitating these clinical discussions.
    DOI:  https://doi.org/10.1080/23794925.2026.2633992
  18. J Emerg Trauma Shock. 2026 Jul-Sep;19(3):19(3): 115-120
       Introduction: The purpose of the study is to compare analgesia and sedation administration among pediatric major trauma patients managed in the pediatric emergency department (PED) versus the general emergency department (GED).
    Methods: This retrospective cohort study included pediatric trauma patients (<16 years) with an injury severity score (ISS) >15 treated at a single trauma center. Between 2013 and 2015, patients were managed primarily by surgeons in the GED; between 2019 and 2023, by pediatric emergency medicine physicians in the PED, following a 3-year transition period. Data on demographics, injury characteristics, pain assessment, and analgesia/sedation were extracted from the trauma registry and medical records. The primary outcome was analgesia administration rate. Secondary analyses compared provider type and analgesia rates between pediatric and adult trauma patients treated in the GED.
    Results: Seventy-three pediatric patients met inclusion criteria (GED: 36; PED: 37). ISS scores were similar (GED: 16 [interquartile range (IQR) 16-19.5] vs. PED: 17 [IQR 16-21], P = 0.16). Analgesia was administered to 48.6% of PED patients versus 33.3% in the GED (P = 0.18). Opioid use was 19% versus 13.8%, and sedative use was 21.6% versus 8.3%, respectively. Pain score documentation was more consistent in the PED. Children treated in the GED received significantly less analgesia than adults with similar ISS scores treated in the same department (33.3% vs. 78.3%, P < 0.0001).
    Conclusions: Analgesia administration in severely injured children remained low across both emergency settings. While trends suggested improved management in the PED, findings may reflect broader changes in care over time, highlighting the ongoing need for standardized pain assessment and treatment protocols in pediatric trauma care.
    Keywords:  Analgesia; pediatric emergency; trauma
    DOI:  https://doi.org/10.4103/jets.jets_173_25
  19. Am J Med Qual. 2026 Oct 06.
       BACKGROUND: Though emphasized as a quality metric, sepsis quality measure (SEP-1) compliance remains low nationwide. Electronic health record (EHR)-based interventions show promise, but few have examined EHR laboratory reference value misconfiguration as a distinct driver of noncompliance.
    LOCAL PROBLEM: The San Francisco Veterans Affairs, a 110-bed tertiary care center, recorded 3 consecutive quarters of SEP-1 composite performance in the lowest national quintile, nadiring at 31.5%.
    METHODS: A multidisciplinary team applied LEAN-A3 methodology to identify root causes of low SEP-1 performance and design targeted countermeasures. The primary outcome was the percentage of suspected sepsis patients with a serum lactate >2.0 mmol/L who received a repeat lactate within 6 hours. Balancing measures included unnecessary repeat lactates and sepsis mortality.
    INTERVENTIONS: Three EHR-based interventions were implemented between August and November 2025: (1) an Emergency Department Sepsis order-set embedding dual time-spaced lactate orders; (2) a structured Sepsis Evaluation Note template; and (3) a clinical decision support alert for patients with serum lactate >2.0 mmol/L, implemented to address a laboratory reference range misconfiguration.
    RESULTS: Postintervention lactate reassessment compliance rose 14 percentage points (54%-68%), meeting Institute for Healthcare Improvement criteria for special cause variation. Facility 12-month rolling performance rose from 31.5% (lowest quintile) to 64.7% (middle quintile), reaching a quarterly high of 74.3%. No increase in unnecessary repeat lactates or sepsis mortality was detected.
    CONCLUSIONS: EHR-embedded structural interventions produced sustained SEP-1 improvement without impacting laboratory utilization or mortality, offering a reproducible model for improvement through systems redesign rather than education alone.
    Keywords:  Sepsis; clinical decision support systems; healthcare quality measures; quality improvement
    DOI:  https://doi.org/10.1097/JMQ.0000000000000357
  20. Cureus. 2026 Sep;18(9): e115899
      Suicide is a leading cause of premature death among US youth, and suicidal thoughts can emerge before adolescence. Adverse childhood experiences (ACEs) are established risk factors for suicidal ideation, while positive childhood experiences (PCEs) and related protective factors may reduce risk, yet no prior synthesis has quantified these associations across independent US pediatric and adolescent samples using effect estimates verified against their source publications. We searched PubMed/MEDLINE, PubMed Central, Centers for Disease Control and Prevention (CDC) publication databases, and reference lists for US-based studies that enrolled children or adolescents younger than 18 years, measured ACEs (cumulative or specific) and/or PCEs or analogous protective factors, reported self-reported suicidal ideation, and published a relative effect estimate with a 95% confidence interval (CI); one report per independent sample entered each pooled analysis. Estimates were pooled with DerSimonian-Laird random-effects models, risk of bias was assessed with the Newcastle-Ottawa Scale, and funnel-plot symmetry and Egger's test were examined for the primary pool but, with fewer than 10 studies, are reported only as exploratory. Eleven reports from 10 independent US samples met the criteria. In the primary meta-analysis of four independent samples, the highest ACE-exposure category (typically three to four or more ACEs) versus no ACEs was associated with substantially higher prevalence of suicidal ideation (pooled relative estimate: 7.19; 95% CI: 5.66-9.14; I-squared = 35%). A graded dose-response was evident, with pooled estimates of 2.78 (95% CI: 2.25-3.43) for the lowest ACE category and 4.60 (95% CI: 3.79-5.58) for intermediate categories, and in two studies reporting per-unit effects, each additional ACE was associated with 60% higher odds of suicidal ideation (pooled odds ratio: 1.60; 95% CI: 1.52-1.69; I-squared = 0%). Protective associations were consistent but not pooled: each additional PCE was associated with 13% lower risk of lifetime suicidal ideation at ages 11-12 (risk ratio: 0.87; 95% CI: 0.82-0.93), and parental monitoring, school connectedness, and family communication were associated with roughly 26-59% lower prevalence of ideation. Risk of bias was moderate for nine reports and high for two. Cumulative ACE exposure thus shows a strong, graded association with suicidal ideation among US children and adolescents, and protective childhood experiences and relationships are consistently associated with lower risk; because the pooled evidence is predominantly cross-sectional and adolescent, prospective preadolescent cohorts remain a priority, and these findings support combined risk- and strengths-based screening and prevention in pediatric and school settings.
    Keywords:  adolescent; adverse childhood experiences; child; meta-analysis; positive childhood experiences; protective factors; suicidal ideation; systematic review
    DOI:  https://doi.org/10.7759/cureus.115899
  21. Inflamm Bowel Dis. 2026 Oct 08. pii: izag203. [Epub ahead of print]
       BACKGROUND: The therapeutic landscape of pediatric ulcerative colitis (UC) has evolved substantially with the introduction of multiple advanced therapies, creating new challenges in selecting the most appropriate initial treatment. While infliximab has long served as the reference biologic, biologics with different mechanisms of action and small-molecule therapies have expanded therapeutic options. However, the pediatric evidence supporting first-line advanced therapy remains heterogeneous across currently available agents.
    METHODS: This review critically summarizes the current pediatric evidence supporting first-line advanced therapies for UC, focusing on anti-tumor necrosis factor therapy, vedolizumab, ustekinumab, selective interleukin-23 inhibitors, and other emerging advanced therapies. We evaluate the maturity, characteristics, and direct applicability of the available evidence to biologic-naïve pediatric patients and discuss the major limitations of the current literature.
    RESULTS: Among currently available therapies, anti-tumor necrosis factor therapy, particularly infliximab, is supported by the most comprehensive prospective pediatric evidence. In contrast, evidence for vedolizumab, ustekinumab, and selective IL-23 inhibitors has accumulated more recently and remains comparatively limited. Across all therapeutic classes, direct comparative studies in biologic-naïve pediatric patients are lacking, and evidence supporting individualized treatment selection remains insufficient.
    CONCLUSIONS: Current pediatric evidence supports the efficacy of multiple advanced therapies and has characterized important safety outcomes; however, evidence establishing therapeutic efficacy should be distinguished from evidence directly informing first-line treatment selection. Future pediatric research should increasingly generate comparative and predictive evidence that informs which effective advanced therapy should be selected first and for whom.
    Keywords:  biologic-naïve; biological products; child; first-line advanced therapy; ulcerative colitis
    DOI:  https://doi.org/10.1093/ibd/izag203
  22. Palliat Support Care. 2026 Oct 08. 24 e256
       OBJECTIVES: Grief and bereavement care (GBC) remains an underrecognized component of pediatric palliative care (PPC), contributing to the emotional and psychological burden experienced by patients, families, and healthcare professionals (HCPs). This perspective review examines gaps in GBC, defines key types of grief in pediatric settings, and proposes a framework to improve patient- and family-centered grief support.
    METHODS: We conducted a narrative perspective review using PubMed and Google Scholar to identify literature on GBC in PPC. Search terms included combinations of "grief," "bereavement," "pediatric palliative care," "children," "caregivers," "siblings," "healthcare professionals," "anticipatory grief," "complicated grief," and "prolonged grief disorder." Publications from 2020 onward were prioritized, with seminal earlier studies included when clinically or conceptually relevant.
    RESULTS: GBC in PPC differs from adult models because of developmental considerations, prolonged illness trajectories, and family-centered decision-making. Relevant forms of grief include anticipatory, disenfranchised, complicated, and prolonged grief, affecting patients, families, and HCPs. Effective approaches include early palliative care integration, legacy-making activities, structured communication, and interdisciplinary psychosocial support. However, global disparities persist, and HCPs frequently report inadequate training and institutional support.
    SIGNIFICANCE OF RESULTS: GBC should be viewed as a longitudinal, culturally sensitive, system-wide responsibility extending from diagnosis through bereavement. Integrated frameworks emphasizing early communication, patient- and family-centered care, and formal grief training for HCPs may strengthen bereavement support and reduce unmet psychosocial needs across the pediatric illness trajectory.
    Keywords:  bereavement; death; grief; pain; pediatric palliative care; pediatrics
    DOI:  https://doi.org/10.1017/S1478951526103824
  23. Aust Occup Ther J. 2026 Oct;73(5): e70128
       INTRODUCTION: Pressure injuries are a significant health concern for individuals with mobility impairments, impacting participation and quality of life. Sport is a meaningful leisure occupation for many but poses unique occupational, physical, and environmental challenges which increase the risk of pressure injuries. Occupational therapists can support those with mobility impairments in balancing pressure injury risk and participation in sport; however, little is known about effective management in sport. This scoping review aimed to map existing evidence on pressure injury prevention and management approaches among individuals with mobility impairments participating in disability sports.
    METHODS: A systematic search of six databases, grey literature, policy documents, and guidelines was conducted in August 2025. Sources were included if they addressed individuals of any age, participating in sports using adaptive equipment and reported prevention or management approaches for pressure injuries. Findings were synthesised using the International Classification of Functioning, Disability and Health (ICF) framework.
    CONSUMER AND COMMUNITY INVOLVEMENT: Consumers and community members were not involved in this scoping review.
    RESULTS: Ten sources met inclusion criteria, with representation from eight disability sports: seven quantitative studies, one mixed methods study, one position statement, and one clinical guideline. Owing to the immaturity of the field, both the clinical guideline and position statement drew on minimal evidence specific to sport, limiting their applicability.
    CONCLUSION: Evidence on pressure injury prevention and management in disability sport is largely focused on the body functions and structures domain, with limited consideration for activities, participation, and environmental factors that influence risk. The evidence base remains underdeveloped, limiting occupational therapists' access to evidence-informed strategies for pressure injury prevention and management in this population. Future research should prioritise occupational analyses of sports participation, mapping tasks, environments, and equipment interfaces across different sports and athlete groups. Generating sport-specific evidence will enable robust guidelines and occupation-based interventions that align with athletes' real-world experiences.
    Keywords:  adaptive sports; decubitus; para sport; persons with disabilities; pressure ulcer; wheelchair sport; wound care
    DOI:  https://doi.org/10.1111/1440-1630.70128
  24. Nurs Manage. 2026 Oct 07.
       BACKGROUND: Central line-associated bloodstream infections (CLABSIs) remain a major source of preventable patient harm and are associated with increased mortality, longer hospital stays, and higher health care costs. Reducing central venous access device (CVAD) utilization and improving line maintenance practices are key strategies for prevention.
    PURPOSE: To reduce CLABSIs through a nurse-led, multidisciplinary initiative focused on parenteral nutrition (PN) stewardship, CVAD maintenance, and shared accountability for line necessity and care.
    METHODS: Using Plan-Do-Study-Act cycles, an interprofessional team implemented a PN clinical decision tree, standardized PN administration kit, targeted nursing education, daily multidisciplinary line rounds, and real-time escalation processes. Outcomes included CLABSI Standardized Infection Ratio (SIR), Standardized Utilization Ratio (SUR), PN-related CLABSIs, and adherence to line care practices.
    RESULTS: The initiative was associated with a 46% reduction in CLABSI SIR (1.165-0.632), an 11.7% reduction in CVAD utilization (SUR 0.479-0.423; P < .001), and a decrease in PN-related CLABSIs from 45% to 12.5% of all CLABSI cases. Process-related issues identified during rounds decreased from 32.73% to 26.11%.
    CONCLUSIONS: A nurse-led, multidisciplinary approach combining PN stewardship, standardized CVAD care, and real-time feedback improved patient safety and reduced CLABSI risk. The model offers a sustainable, replicable strategy for infection prevention.
    Keywords:  central line-associated bloodstream infections (CLABSI); central venous access devices (CVAD); infection prevention; nursing leadership; parenteral nutrition (PN); patient monitoring; quality improvement
    DOI:  https://doi.org/10.1097/nmg.0000000000000414
  25. Dent Traumatol. 2026 Oct 07.
      Mandibular condylar fractures are common mandibular injuries in children. Conservative treatment is generally favored because of the remodeling capacity of the growing condyle, although rehabilitation protocols and the criteria for operative treatment remain variable. This systematic review synthesized current evidence on the clinical and radiographic outcomes of conservative management of pediatric mandibular condylar fractures. The review was conducted according to PRISMA 2020 and included original clinical studies published between 2016 and 2026. Ten studies met the predefined eligibility criteria. Conservative treatment was generally associated with favorable recovery of mandibular function, satisfactory occlusal stability, and progressive condylar remodeling, although residual radiographic alterations were common. Younger age was associated with greater remodeling potential. Because most included studies were retrospective and heterogeneous in fracture classification, treatment protocols, outcome definitions, imaging, and follow-up, no single conservative protocol could be identified as superior. Conservative functional management is an appropriate first-line option for many pediatric condylar fractures, but treatment must be individualized. Functional status and its evolution-including pain, mouth opening, mandibular excursions, mastication, occlusal stability, and facial symmetry-should be considered together with age, fracture characteristics, associated injuries, and remodeling potential when deciding between continued conservative care and surgery.
    Keywords:  condylar remodeling; conservative treatment; functional rehabilitation; pediatric mandibular condylar fracture
    DOI:  https://doi.org/10.1111/edt.70139