bims-climfi Biomed News
on Cerebellar cortical circuitry
Issue of 2024‒05‒05
one paper selected by
Jun Maruta, Mount Sinai Health System

  1. Neuron. 2024 Apr 26. pii: S0896-6273(24)00248-4. [Epub ahead of print]
      Molecular layer interneurons (MLIs) account for approximately 80% of the inhibitory interneurons in the cerebellar cortex and are vital to cerebellar processing. MLIs are thought to primarily inhibit Purkinje cells (PCs) and suppress the plasticity of synapses onto PCs. MLIs also inhibit, and are electrically coupled to, other MLIs, but the functional significance of these connections is not known. Here, we find that two recently recognized MLI subtypes, MLI1 and MLI2, have a highly specialized connectivity that allows them to serve distinct functional roles. MLI1s primarily inhibit PCs, are electrically coupled to each other, fire synchronously with other MLI1s on the millisecond timescale in vivo, and synchronously pause PC firing. MLI2s are not electrically coupled, primarily inhibit MLI1s and disinhibit PCs, and are well suited to gating cerebellar-dependent behavior and learning. The synchronous firing of electrically coupled MLI1s and disinhibition provided by MLI2s require a major re-evaluation of cerebellar processing.
    Keywords:  Purkinje cell; cerebellum; circuit; connectomics; disinhibition; electrical coupling; inhibition; in vivo recording; molecular layer interneuron; paired recordings; synchrony