bims-climfi Biomed News
on Cerebellar cortical circuitry
Issue of 2022‒07‒10
one paper selected by
Jun Maruta
Mount Sinai Health System


  1. Annu Rev Neurosci. 2022 Jul 08. 45 151-175
      The cerebellar cortex is an important system for relating neural circuits and learning. Its promise reflects the longstanding idea that it contains simple, repeated circuit modules with only a few cell types and a single plasticity mechanism that mediates learning according to classical Marr-Albus models. However, emerging data have revealed surprising diversity in neuron types, synaptic connections, and plasticity mechanisms, both locally and regionally within the cerebellar cortex. In light of these findings, it is not surprising that attempts to generate a holistic model of cerebellar learning across different behaviors have not been successful. While the cerebellum remains an ideal system for linking neuronal function with behavior, it is necessary to update the cerebellar circuit framework to achieve its great promise. In this review, we highlight recent advances in our understanding of cerebellar-cortical cell types, synaptic connections, signaling mechanisms, and forms of plasticity that enrich cerebellar processing.
    Keywords:  Purkinje cell; cerebellar circuit; cerebellar interneurons; climbing fiber; ephaptic signaling; motor learning
    DOI:  https://doi.org/10.1146/annurev-neuro-091421-125115