bims-climfi Biomed News
on Cerebellar cortical circuitry
Issue of 2021–02–28
two papers selected by
Jun Maruta, Mount Sinai Health System
  1. Part I: The Complex Spikes as One of the Cerebellar Secrets.
  2. Part II. J. C. Eccles, R. Llinas and K. Sasaki, The Excitatory Synaptic Action of Climbing Fibres on the Purkinje Cells of the Cerebellum, J Physiol, 182: 268-296, 1966: the Rise of the Complex Spike.
  1. Cerebellum. 2021 Feb 27.
    Part I: The Complex Spikes as One of the Cerebellar Secrets.
    Mario Manto, Lazaros C Triarhou.
      The olivocerebellar tract has unique morphological, physiological, and developmental properties. Olivocerebellar axons are the source of multiple climbing fibers (CFs). The synapse between CFs and the Purkinje neuron is one of the most powerful excitatory in the central nervous system. Complex spikes are composed of an initial large amplitude spike followed by spikelets. The spatiotemporal patterns of complex/simple spikes complement the rate coding to enhance the accuracy of motor and cognitive processing, and to improve predictions related to internal models. Understanding the role of complex spikes is essential in clarifying how the cerebellar cortex contributes to learning, motor control, cognitive tasks, and the processing of emotions. This Cerebellar Classic is devoted to the pioneering work of Eccles, Llinás, and Sasaki on complex spikes using intracellular recordings from Purkinje neurons.
    Keywords:  Cerebellum; Complex spikes; Inferior olivary complex; Simple spikes
    DOI:  https://doi.org/10.1007/s12311-021-01243-w
  2. Cerebellum. 2021 Feb 27.
    Part II. J. C. Eccles, R. Llinas and K. Sasaki, The Excitatory Synaptic Action of Climbing Fibres on the Purkinje Cells of the Cerebellum, J Physiol, 182: 268-296, 1966: the Rise of the Complex Spike.
    Christian Hansel.
      
    DOI:  https://doi.org/10.1007/s12311-021-01244-9
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