bims-climfi Biomed News
on Climbing fiber action on the cerebellar interneurons.
Issue of 2018‒05‒20
one paper selected by
Jun Maruta
Mount Sinai Health System

  1. J Chem Neuroanat. 2018 May 15. pii: S0891-0618(18)30021-8. [Epub ahead of print]92 16-24
      The review deals with topical issues of the neuronal arrangement underlying basic cerebellar functions. The cerebellum and its auxiliary structures contain several hundreds of modules (so called "microzones"). Each module receives the corticopetal input specific for the lobule it belongs to and forms the topographic projection. The precision of the major input-output signal flow in the cerebellar cortex is provided by a pronounced stratification of its synaptic zones of a various origin and regular topography of its afferent connections, interneurons, and efferent neurons. There is a nice match between the anatomical and functional coordinates of the modules, whose spatial boundaries are determined by the spread of afferent excitation and local interneuron connections. The dynamic characteristics of the modules are analyzed by the example of the formation of the nitrergic neuron ensembles and cerebellar projections of corticopetal fibers. The authors discuss the cerebellar blood flow and its relation to the activity of NO/GABAergic Lugaro cells and other interneurons in the cerebellar cortex. A generalized scheme of intra- and intermodular communication is proposed.
    Keywords:  Blood flow regulation; Corticonuclear cerebellar microcomplex; Interneuron integration models; Modular microcircuits; Neurochemical diversity