bims-ciryme Biomed News
on Circadian rhythms and metabolism
Issue of 2026–08–30
two papers selected by
Gabriela Da Silva Xavier, University of Birmingham
  1. Tissue corticosteroid rhythms are dysregulated predominantly during sleep in primary aldosteronism.
  2. Intermittent time-restricted feeding recapitulates the physiological benefits of daily time-restricted feeding in male mice with chronic metabolic disease.
  1. Sci Transl Med. 2026 Aug 26. 18(864): eaeb7517
    Tissue corticosteroid rhythms are dysregulated predominantly during sleep in primary aldosteronism.
    Marianne A Grytaas, Thomas Upton, Isabella Marinelli, Paal Methlie, Marianne Øksnes, Dimitra A Vassiliadi, Sophie Bensing, Georgina Russell, Kristian Løvås, Dimitris Margaritopoulos, Ileana R Botusan, Katerina Simunkova, Maria Balomenaki, Katarina Berinder, Belinda Lombard, Thea Sjøgren, Ida Løvik, Bergithe E Oftedal, Anette Heie, Grethe Å Ueland, Olle Kämpe, Stylianos Tsagarakis, Stafford L Lightman, Eder Zavala, Eystein S Husebye.
      Primary aldosteronism affects 5 to 20% of the hypertensive population and is associated with increased cardiovascular and metabolic risk compared with primary hypertension. Alterations in the dynamics of aldosterone secretion are key, but these are not well captured by current diagnostic pathways, and the disease is often missed. In this proof-of-concept study, we used ambulatory microdialysis sampling to continuously monitor tissue corticosteroid dynamics in primary aldosteronism over 24 hours. In a cohort of 60 patients, we found pulsatile nocturnal hypersecretion of aldosterone and the hybrid steroids 18-hydroxycortisol and 18-oxocortisol with a preserved daily rhythm. This was most prominent in unilateral disease, with normalization after adrenalectomy. Our findings confirm that a key pathophysiological feature of primary aldosteronism is disruption of corticosteroid rhythms rather than persistent elevation of hormones. We show that ambulatory dynamic hormone profiling is a viable technique that offers substantially more information than current diagnostic approaches relying on single-time point hormone measurements. In the future, this offers the opportunity to investigate more subtle dynamic phenotypes and potentially earlier detection of disease.
    DOI:  https://doi.org/10.1126/scitranslmed.aeb7517
  2. Mol Metab. 2026 Aug 25. pii: S2212-8778(26)00116-X. [Epub ahead of print] 102432
    Intermittent time-restricted feeding recapitulates the physiological benefits of daily time-restricted feeding in male mice with chronic metabolic disease.
    Andre Sarmento-Cabral, Marta G Novelle, Luz Marina Sánchez-Mendoza, Natalia Herman-Sanchez, Samanta Lozano de la Haba, Marta Rodriguez-Vazquez, Pablo Iturbe, Eduardo Chicano-Gálvez, Francisco Javier Cubero, Raul M Luque, Jose Cordoba-Chacon, Juan L Lopez-Canovas, Jose M Villalba, Manuel D Gahete, Alberto Diaz-Ruiz.
      Time-restricted feeding (TRF) is proposed as a relevant strategy to counteract obesity and metabolic disorders; however, the therapeutic efficacy of more pragmatic intermittent TRF (iTRF) regimens remains undefined. Herein, daily and intermittent TRF significantly improved whole-body physiology, promoted key hallmarks of energy restriction, and induced coordinated transcriptional and lipidomic remodeling in male mice with chronic metabolic dysfunction previously established by prolonged high-fat, high-cholesterol, high-fructose feeding. These effects were summarized using three composite scores (physiological/metabolic, energy restriction, and lipidic), which showed consistent associations with each other, suggesting convergence toward a TRF-associated metabolic state across biological scales. Lipidomic profiling identified a subset of hepatic lipids associated with systemic health, pointing to lipid remodeling, particularly at the endoplasmic reticulum, as a potential feature of the TRF response. Notably, TRF failed to histologically improve hepatic steatosis, ballooning, or inflammation, and its overall benefits were clearly inferior to dietary normalization to standard chow diet. Altogether, these data (i) demonstrate that intermittent TRF recapitulates the beneficial effects in advanced metabolic disease, (ii) provides translational support for flexible TRF strategies, and (iii) highlights the need to integrate TRF with additional therapeutic strategies.
    Keywords:  Lipidomics; Metabolic homeostasis; Time restricted feeding; Whole-body physiology
    DOI:  https://doi.org/10.1016/j.molmet.2026.102432
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