bims-ciryme 2023-06-18 papers

Issue of 2023‒06‒18
two papers selected by
Gabriela Da Silva Xavier
University of Birmingham

Front Physiol. 2023 ;14 1195001

Preservation of ∼12-h ultradian rhythms of gene expression of mRNA and protein metabolism in the absence of canonical circadian clock.

Bokai Zhu, Silvia Liu.

Introduction: Besides the ∼24-h circadian rhythms, ∼12-h ultradian rhythms of gene expression, metabolism and behaviors exist in animals ranging from crustaceans to mammals. Three major hypotheses were proposed on the origin and mechanisms of regulation of ∼12-h rhythms, namely, that they are not cell-autonomous and controlled by a combination of the circadian clock and environmental cues, that they are regulated by two anti-phase circadian transcription factors in a cell autonomous manner, or that they are established by a cell-autonomous ∼12-h oscillator. Methods: To distinguish among these possibilities, we performed a post hoc analysis of two high temporal resolution transcriptome dataset in animals and cells lacking the canonical circadian clock. Results: In both the liver of BMAL1 knockout mice and Drosophila S2 cells, we observed robust and prevalent ∼12-h rhythms of gene expression enriched in fundamental processes of mRNA and protein metabolism that show large convergence with those identified in wild-type mice liver. Bioinformatics analysis further predicted ELF1 and ATF6B as putative transcription factors regulating the ∼12-h rhythms of gene expression independently of the circadian clock in both fly and mice. Discussion: These findings provide additional evidence to support the existence of an evolutionarily conserved 12-h oscillator that controls ∼12-h rhythms of gene expression of protein and mRNA metabolism in multiple species.

Keywords: Drosophila S2 cell; X-box binding protein 1 (XBP1); mRNA metabolism; proteostasis; ultradian and circadian rhythms

DOI: https://doi.org/10.3389/fphys.2023.1195001

J Clin Endocrinol Metab. 2023 Jun 16. pii: dgad225. [Epub ahead of print]

Hormones and Aging: An Endocrine Society Scientific Statement.

Anne R Cappola, Richard J Auchus, Ghada El-Hajj Fuleihan, David J Handelsman, Rita R Kalyani, Michael McClung, Cynthia A Stuenkel, Michael O Thorner, Joseph G Verbalis.

Multiple changes occur across various endocrine systems as an individual ages. The understanding of the factors that cause age-related changes and how they should be managed clinically is evolving. This statement reviews the current state of research in the growth hormone, adrenal, ovarian, testicular, and thyroid axes, as well as in osteoporosis, vitamin D deficiency, type 2 diabetes, and water metabolism, with a specific focus on older individuals. Each section describes the natural history and observational data in older individuals, available therapies, clinical trial data on efficacy and safety in older individuals, key points, and scientific gaps. The goal of this statement is to inform future research that refines prevention and treatment strategies in age-associated endocrine conditions, with the goal of improving the health of older individuals.

Keywords: adrenal; androgen; diabetes; endocrinology; estrogen; growth hormone; osteoporosis; thyroid; vitamin D; water metabolism

DOI: https://doi.org/10.1210/clinem/dgad225