bims-biprem Biomed News
on Bioprinting for regenerative medicine
Issue of 2024–10–06
seven papers selected by
Seerat Maqsood, University of Teramo
  1. Advancements in Tissue Engineering: A Review of Bioprinting Techniques, Scaffolds, and Bioinks.
  2. Photocuring 3D printing technology as an advanced tool for promoting angiogenesis in hypoxia-related diseases.
  3. Review on Engineering of Bone Scaffolds Using Conventional and Additive Manufacturing Technologies.
  4. The Applications of 3D-Printing Technology in Prosthodontics: A Review of the Current Literature.
  5. Pharmacy 3D printing.
  6. 3D Models Currently Proposed to Investigate Human Skin Aging and Explore Preventive and Reparative Approaches: A Descriptive Review.
  7. Tissue engineered three-dimensional platforms for disease modeling and therapeutic development.
  1. Biomed Eng Comput Biol. 2024 ;15 11795972241288099
    Advancements in Tissue Engineering: A Review of Bioprinting Techniques, Scaffolds, and Bioinks.
    Shervin Zoghi.
      Tissue engineering is a multidisciplinary field that uses biomaterials to restore tissue function and assist with drug development. Over the last decade, the fabrication of three-dimensional (3D) multifunctional scaffolds has become commonplace in tissue engineering and regenerative medicine. Thanks to the development of 3D bioprinting technologies, these scaffolds more accurately recapitulate in vivo conditions and provide the support structure necessary for microenvironments conducive to cell growth and function. The purpose of this review is to provide a background on the leading 3D bioprinting methods and bioink selections for tissue engineering applications, with a specific focus on the growing field of developing multifunctional bioinks and possible future applications.
    Keywords:  3D printing; Bioprinting; bioink; scaffold; tissue engineering
    DOI:  https://doi.org/10.1177/11795972241288099
  2. J Tissue Eng. 2024 Jan-Dec;15:15 20417314241282476
    Photocuring 3D printing technology as an advanced tool for promoting angiogenesis in hypoxia-related diseases.
    Sang Yoon Lee, Huynh Dai Phuc, Soong Ho Um, Rosaire Mongrain, Jeong-Kee Yoon, Suk Ho Bhang.
      Three-dimensional (3D) bioprinting has emerged as a promising strategy for fabricating complex tissue analogs with intricate architectures, such as vascular networks. Achieving this necessitates bioink formulations that possess highly printable properties and provide a cell-friendly microenvironment mimicking the native extracellular matrix. Rapid advancements in printing techniques continue to expand the capabilities of researchers, enabling them to overcome existing biological barriers. This review offers a comprehensive examination of ultraviolet-based 3D bioprinting, renowned for its exceptional precision compared to other techniques, and explores its applications in inducing angiogenesis across diverse tissue models related to hypoxia. The high-precision and rapid photocuring capabilities of 3D bioprinting are essential for accurately replicating the intricate complexity of vascular networks and extending the diffusion limits for nutrients and gases. Addressing the lack of vascular structure is crucial in hypoxia-related diseases, as it can significantly improve oxygen delivery and overall tissue health. Consequently, high-resolution 3D bioprinting facilitates the creation of vascular structures within three-dimensional engineered tissues, offering a potential solution for addressing hypoxia-related diseases. Emphasis is placed on fundamental components essential for successful 3D bioprinting, including cell types, bioink compositions, and growth factors highlighted in recent studies. The insights provided in this review underscore the promising prospects of leveraging 3D printing technologies for addressing hypoxia-related diseases through the stimulation of angiogenesis, complementing the therapeutic efficacy of cell therapy.
    Keywords:  Angiogenesis; bioink compositions; cell type; growth factor; ultraviolet-based 3D bioprinting
    DOI:  https://doi.org/10.1177/20417314241282476
  3. 3D Print Addit Manuf. 2024 Aug;11(4): 1418-1440
    Review on Engineering of Bone Scaffolds Using Conventional and Additive Manufacturing Technologies.
    Abdullah Mohammed, Amaia Jiménez, Prveen Bidare, Amr Elshaer, Adnan Memic, Hany Hassanin, Khamis Essa.
      Bone is a complex connective tissue that serves as mechanical and structural support for the human body. Bones' fractures are common, and the healing process is physiologically complex and involves both mechanical and biological aspects. Tissue engineering of bone scaffolds holds great promise for the future treatment of bone injuries. However, conventional technologies to prepare bone scaffolds cannot provide the required properties of human bones. Over the past decade, three-dimensional (3D) printing or additive manufacturing technologies have enabled control over the creation of bone scaffolds with personalized geometries, appropriate materials, and tailored pores. This article aims to review recent advances in the fabrication of bone scaffolds for bone repair and regeneration. A detailed review of bone fracture repair and an in-depth discussion on conventional manufacturing and 3D printing techniques are introduced with an emphasis on novel studies concepts, potentials, and limitations.
    Keywords:  3D printing; additive manufacturing; bone scaffolds; conventional manufacturing
    DOI:  https://doi.org/10.1089/3dp.2022.0360
  4. Cureus. 2024 Sep;16(9): e68501
    The Applications of 3D-Printing Technology in Prosthodontics: A Review of the Current Literature.
    Mohammed H Alyami.
      Prosthodontics has become increasingly popular because of its cosmetic attractiveness. 3D printing has revolutionized prosthodontics, enabling the creation of high-quality dental prostheses. It creates detailed restorations, such as crowns, bridges, implant-supported frameworks, surgical templates, dentures, and orthodontic models. In addition, it saves production time but faces challenges such as elevated expenses and the requirement for innovative materials and technologies. This review gives insights into the uses of 3D printing in prosthodontics, presenting how it has significantly changed clinical practices. This article discusses different materials and techniques. Additionally, it showcases the capacity of 3D printing to improve prosthodontic practice and proposes prospects for future investigation.
    Keywords:  3d printing; additive manufacturing; dental implants; dental prosthesis; prosthodontics
    DOI:  https://doi.org/10.7759/cureus.68501
  5. Biofabrication. 2024 Oct 04.
    Pharmacy 3D printing.
    Jessica Cheng, Edwin Tan, Lifeng Kang.
      A significant limitation of the "one size fits all" medication approach is the lack of consideration for special population groups. 3D printing technology has revolutionised the landscape of pharmaceuticals and pharmacy practice, playing an integral role in enabling on-demand production of customised medication. Compared to traditional pharmaceutical processes, 3D printing has major advantages in producing tailored dosage forms with unique drug release mechanisms. Moreover, this technology has enabled the combination of multiple drugs in a single formulation addressing key issues of medication burden. Development of 3D printing in clinical applications and large-scale pharmaceutical manufacturing has substantially increased in recent years. This review focuses on the emergence of extrusion-based 3D printing, particularly semi solid extrusion, fused deposition modelling and direct powder extrusion, which are currently the most commonly studied in pharmacy practice. The concept of each technique is summarised, with examples of current and potential applications. Next, recent advancements in the 3D printer market and pharmacist perceptions are discussed. Finally, the benefits, challenges and prospects of pharmacy 3D printing technology are highlighted, emphasising its significance in changing the future of this field.
    Keywords:  3D printing; additive manufacturing; direct powder extrusion; fused deposition modelling; pharmacy practice; semi solid extrusion
    DOI:  https://doi.org/10.1088/1758-5090/ad837a
  6. Biomolecules. 2024 Aug 26. pii: 1066. [Epub ahead of print]14(9):
    3D Models Currently Proposed to Investigate Human Skin Aging and Explore Preventive and Reparative Approaches: A Descriptive Review.
    Francesca Lombardi, Francesca Rosaria Augello, Alessia Ciafarone, Valeria Ciummo, Serena Altamura, Benedetta Cinque, Paola Palumbo.
      Skin aging is influenced by intrinsic and extrinsic factors that progressively impair skin functionality over time. Investigating the skin aging process requires thorough research using innovative technologies. This review explores the use of in vitro human 3D culture models, serving as valuable alternatives to animal ones, in skin aging research. The aim is to highlight the benefits and necessity of improving the methodology in analyzing the molecular mechanisms underlying human skin aging. Traditional 2D models, including monolayers of keratinocytes, fibroblasts, or melanocytes, even if providing cost-effective and straightforward methods to study critical processes such as extracellular matrix degradation, pigmentation, and the effects of secretome on skin cells, fail to replicate the complex tissue architecture with its intricated interactions. Advanced 3D models (organoid cultures, "skin-on-chip" technologies, reconstructed human skin, and 3D bioprinting) considerably enhance the physiological relevance, enabling a more accurate representation of skin aging and its peculiar features. By reporting the advantages and limitations of 3D models, this review highlights the importance of using advanced in vitro systems to develop practical anti-aging preventive and reparative approaches and improve human translational research in this field. Further exploration of these technologies will provide new opportunities for previously unexplored knowledge on skin aging.
    Keywords:  3D bioprinting; 3D skin models; aging; human skin; pseudo-3D system; reconstructed human skin; skin microbiota; skin organoids; skin-on-chip
    DOI:  https://doi.org/10.3390/biom14091066
  7. Tissue Eng Part B Rev. 2024 Sep 30.
    Tissue engineered three-dimensional platforms for disease modeling and therapeutic development.
    Erika E Wheeler, Kent Leach.
      Three-dimensional (3D) tissue engineered models are under investigation to recapitulate tissue architecture and functionality, thereby overcoming limitations of traditional 2D cultures and preclinical animal models. This review highlights recent developments in 3D platforms designed to model diseases in vitro that affect numerous tissues and organs, including cardiovascular, gastrointestinal, bone marrow, neural, reproductive, and pulmonary systems. We discuss current technologies for engineered tissue models, highlighting the advantages, limitations, and important considerations for modeling tissues and diseases. Lastly, we discuss future advancements necessary to enhance the reliability of 3D models of tissue development and disease.
    DOI:  https://doi.org/10.1089/ten.TEB.2024.0212
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