bims-biprem 2024-09-22 papers

bims-biprem

Biomed News

on Bioprinting for regenerative medicine

Issue of 2024–09–22
eight papers selected by
Seerat Maqsood, University of Teramo

A Futuristic Development in 3D Printing Technique Using Nanomaterials with a Step Toward 4D Printing.
Current applications of three-dimensional (3D) printing in pediatric dentistry: a literature review.
Transformative Potential and Healthcare Applications of 3D Printing.
3-Dimensional printing in vascular disease: From manufacturer to clinical use.
Recent advances in hydrogels applications for tissue engineering and clinical trials.
3-D bioprinted human-derived skin organoids accelerate full-thickness skin defects repair.
The promising approach of 3D bioprinting for diabetic foot ulcer treatment: A concise review of recent developments.
Recent Developments and Applications of 3D-Printing Technology in Pharmaceutical Drug Delivery Systems: A New Research Direction and Future Trends.

ACS Omega. 2024 Sep 10. 9(36): 37445-37458

A Futuristic Development in 3D Printing Technique Using Nanomaterials with a Step Toward 4D Printing.

Prachi Agarwal, Vidhi Mathur, Meghana Kasturi, Varadharajan Srinivasan, Raviraja N Seetharam, Kirthanashri S Vasanthan.

3D bioprinting has shown great promise in tissue engineering and regenerative medicine for creating patient-specific tissue scaffolds and medicinal devices. The quickness, accurate imaging, and design targeting of this emerging technology have excited biomedical engineers and translational medicine researchers. Recently, scaffolds made from 3D bioprinted tissue have become more clinically effective due to nanomaterials and nanotechnology. Because of quantum confinement effects and high surface area/volume ratios, nanomaterials and nanotechnological techniques have unique physical, chemical, and biological features. The use of nanomaterials and 3D bioprinting has led to scaffolds with improved physicochemical and biological properties. Nanotechnology and nanomaterials affect 3D bioprinted tissue engineered scaffolds for regenerative medicine and tissue engineering. Biomaterials and cells that respond to stimuli change the structural shape in 4D bioprinting. With such dynamic designs, tissue architecture can change morphologically. New 4D bioprinting techniques will aid in bioactuation, biorobotics, and biosensing. The potential of 4D bioprinting in biomedical technologies is also discussed in this article.

DOI: https://doi.org/10.1021/acsomega.4c04123
J Clin Pediatr Dent. 2024 Sep;48(5): 4-13

Current applications of three-dimensional (3D) printing in pediatric dentistry: a literature review.

Nagehan Aktaş, Volkan Ciftci.

  Advancements in 3D printing technology are providing a new direction in pediatric dentistry by offering innovative solutions to traditional challenges. The remarkable expansion of 3D printing necessitates a comprehensive examination of its status and applications in the dental field, particularly in the pediatric dentistry. This review provides a comprehensive exploration of the applications of 3D printing in pediatric dental practices by drawing from a systematic search across databases, including PubMed/MEDLINE, Scopus, Web of Science, Scielo and the Cochrane Library. The search strategy employed a combination of keywords: "Digital dentistry and 3D printing", "3D printing technology in dentistry", "3D printing in pediatric dentistry" and "3D printing in pediatric dental procedures". The review encompasses a wide array of studies, including original research, cross-sectional analyses, case reports and reviews. A detailed overview is presented in regard to the use of 3D printing for master and educational models, space maintainers, prosthetic restorations, surgical guide, splint design and fracture treatment, fluoride application, autogenous dental transplantation, anterior teeth restoration, and pediatric endodontics and regenerative treatments. This review shows that 3D printing improves clinical outcomes through personalized and precise treatment options and enhances dental students' educational landscape. Areas lacking extensive research were also identified, which warrent further investigation to optimize the integration of 3D printing in pediatric dentistry. By mapping out the current landscape and future directions, the aim of this paper is to support pediatric dentists in recognizing the broad implications of 3D printing for improving patient care and advancing dental education.

Keywords:  3D printing; Additive manufacturing; Dental technology advancements; Digital dentistry; Pediatric dentistry

DOI:  https://doi.org/10.22514/jocpd.2024.099
Curr Pharm Des. 2024 Sep 12.

Transformative Potential and Healthcare Applications of 3D Printing.

Aayush Prakash, Rishabha Malviya Malviya, Deependra Pratap Singh.

  Additive manufacturing, sometimes referred to as 3D printing or AM, has numerous applications in industries like manufacturing, aviation, aerospace, vehicles, and education. It has recently made considerable inroads into the healthcare industry, backed by technology breakthroughs such as fused deposition modeling, binder jetting, and inkjet printing. A variety of biomaterials, such as polycaprolactone, polycarbonate, polypropylene, and polylactic acid, have contributed to this increase. This essay delves into the revolutionary possibilities of 3D printing in healthcare, to shed light on the idea of customized medications via the improvement of efficiency and cost. Researchers are using polymers and additive manufacturing to make customized medical devices. However, obstacles including bureaucratic hurdles, technological developments, and the choice of appropriate materials and printers stand in the way of widespread implementation. To fully realize the promise of 3D printing in healthcare, these challenges must be overcome. The article highlights the revolutionary potential of 3D printing in healthcare by following its development from art and construction to customized drugs and patient-specific medical equipment. In addition to addressing issues like quality control and technological limitations, it emphasizes its wide range of applications in surgical planning, dentistry, and anatomical models. The necessity of adapting regulations and instructional programs is highlighted by discussing future trends like bioprinting and FDA-approved innovations. In order to properly utilize 3D printing in healthcare, this adaption is essential. Personalized prescriptions and increased efficacy from the incorporation of 3D printing could revolutionize the healthcare industry. But even with these advances, problems like choosing the right materials and getting over administrative roadblocks prevent widespread implementation. These challenges need to be successfully overcome for 3D printing in healthcare to reach its full potential.

Keywords:  3D printed drug products; 3D printing; biomaterial; dosage form; personalized medicine; personalized pharmaceuticals.

DOI:  https://doi.org/10.2174/0113816128324761240828064443
Semin Vasc Surg. 2024 Sep;pii: S0895-7967(24)00047-4. [Epub ahead of print]37(3): 326-332

3-Dimensional printing in vascular disease: From manufacturer to clinical use.

Bahaa Nasr, Fabien Lareyre, Samuel Guigo, Kevin Bellenger, Juliette Raffort, Yann Gouëffic.

  Three-dimensional (3D) printing has been used in medicine with applications in many different fields. 3D printing allows patient education, interventionalists training, preprocedural planning, and assists the interventionalist to improve treatment outcomes. 3D printing represents a potential advancement by allowing the printing of flexible vascular models. In this article, the authors report a clinical case using 3D printing to perform a physician-modified fenestrated endograft. An overview of 3D printing in vascular and endovascular surgery is provided, focusing on its potential applications for training, education, preprocedural planning, and current clinical applications.

Keywords:  3D printing; Bioprinting; Endovascular; Vascular disease; Vascular surgery

DOI:  https://doi.org/10.1053/j.semvascsurg.2024.08.002
Regen Ther. 2024 Jun;26 635-645

Recent advances in hydrogels applications for tissue engineering and clinical trials.

Leila Rezakhani, Maliheh Gharibshahian, Majid Salehi, Sepehr Zamani, Zahra Abpeikar, Omid Ghaderzadeh, Morteza Alizadeh, Alireza Masoudi, Nariman Rezaei, Danial Cheraghali.

  Hydrogels are biomolecules made of artificial and natural polymers. Their quasi-three-dimensional structure has created unique features. They are very hydrophilic, and in addition to the high inflation rate, they also have excellent water maintenance capacity, biodegradability, biocompatibility, and strong mechanical properties. These properties are used in many tissue engineering applications. All these features have made these scaffolds widely used as attractive structures in the world of tissue engineering and regeneration medicine. In addition to research, scaffolds entered the field of medicine and are expected to play a significant role in the repair of many tissues in the future. This study aims to review the various polymers involved in hydrogel fabrication and their application in the repair of diverse tissues and clinical trials.

Keywords:  Clinical trials; Hydrogels; Regenerative medicine; Tissue engineering

DOI:  https://doi.org/10.1016/j.reth.2024.08.015
Bioact Mater. 2024 Dec;42 257-269

3-D bioprinted human-derived skin organoids accelerate full-thickness skin defects repair.

Tao Zhang, Shihao Sheng, Weihuang Cai, Huijian Yang, Jiameng Li, Luyu Niu, Wanzhuo Chen, Xiuyuan Zhang, Qirong Zhou, Chuang Gao, Zuhao Li, Yuanwei Zhang, Guangchao Wang, Hao Shen, Hao Zhang, Yan Hu, Zhifeng Yin, Xiao Chen, Yuanyuan Liu, Jin Cui, Jiacan Su.

  The healing of large skin defects remains a significant challenge in clinical settings. The lack of epidermal sources, such as autologous skin grafting, limits full-thickness skin defect repair and leads to excessive scar formation. Skin organoids have the potential to generate a complete skin layer, supporting in-situ skin regeneration in the defect area. In this study, skin organoid spheres, created with human keratinocytes, fibroblasts, and endothelial cells, showed a specific structure with a stromal core surrounded by surface keratinocytes. We selected an appropriate bioink and innovatively combined an extrusion-based bioprinting technique with dual-photo source cross-linking technology to ensure the overall mechanical properties of the 3D bioprinted skin organoid. Moreover, the 3D bioprinted skin organoid was customized to match the size and shape of the wound site, facilitating convenient implantation. When applied to full-thickness skin defects in immunodeficient mice, the 3D bioprinted human-derived skin organoid significantly accelerated wound healing through in-situ regeneration, epithelialization, vascularization, and inhibition of excessive inflammation. The combination of skin organoid and 3D bioprinting technology can overcome the limitations of current skin substitutes, offering a novel treatment strategy to address large-area skin defects.

Keywords:  3D bioprinting; Skin defect; Skin organoid; Wound healing

DOI:  https://doi.org/10.1016/j.bioactmat.2024.08.036
Heliyon. 2024 Sep 15. 10(17): e36707

The promising approach of 3D bioprinting for diabetic foot ulcer treatment: A concise review of recent developments.

Mattia Biondo, Laura Tomasello, Carla Giordano, Giorgio Arnaldi, Giuseppe Pizzolanti.

  Diabetic foot ulcer (DFU), one of the most significant complications of diabetes, is a condition that causes anatomical and functional alterations of the foot resulting in an important social and economic impact, related to disability and health care costs. Recently, three-dimensional bioprinting - which allows the fabrication of complex and biocompatible structures - has been identified as a promising approach in the field of regenerative medicine to promote the healing of chronic wounds, such as DFU. In this concise review we highlight the most relevant and recent attempts of using 3D bioprinted constructs in vivo - both on animals and people - in order to treat non-healing diabetic ulcers and prevent their worsening. Finally, we briefly focus on the future implications of bioprinting, suggesting its forthcoming importance not only for DFU treatment but also for other areas of clinical care.

Keywords:  Bioprinting; Diabetic foot; Foot ulcer; Regenerative medicine; Wounds and injuries

DOI:  https://doi.org/10.1016/j.heliyon.2024.e36707
Curr Pharm Des. 2024 Sep 16.

Recent Developments and Applications of 3D-Printing Technology in Pharmaceutical Drug Delivery Systems: A New Research Direction and Future Trends.

Suryakanta Swain, Bikash Ranjan Jena, Rabinarayan Parhi.

  The advent of 3D printing technology has emerged as a key technical revolution in recent years, enabling the development and production of innovative medication delivery methods in the pharmaceutical sector. The designs, concepts, techniques, key challenges, and potential benefits during 3D-printing technology are the key points discussed in this review. This technology primarily enables rapid, safe, and low-cost development of pharmaceutical formulations during the conventional and additive manufacturing processes. This phenomenon has wide-ranging implications in current as well as future medicinal developments. Advanced technologies such as Ink-Jet printing, drop-on-demand printing, Zip dose, Electrohydrodynamic Printing (Ejet) etc., are the current focus of the drug delivery systems for enhancing patient convenience and improving medication compliance. The current and future applications of various software, such as CAD software, and regulatory aspects in 3D and 4D printing technology are discussed briefly in this article. With respect to the prospective trajectory of 3D and 4D printing, it is probable that the newly developed methods will be predominantly utilized in pharmacies and hospitals to accommodate the unique requirements of individuals or niche groups. As a result, it is imperative that these technologies continue to advance and be improved in comparison to 2D printing in order to surmount the aforementioned regulatory and technical obstacles, render them applicable to a vast array of drug delivery systems, and increase their acceptability among patients of every generation.

Keywords:  4D-printing technology; CAD Software; Ink-jet printing; drop-on-demand printing; zip dose

DOI:  https://doi.org/10.2174/0113816128309717240826101647